1CFAA

Solution structure of a semi-synthetic c5a receptor antagonist at ph 5.2, 303k, nmr, 20 structures
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
71
structure length
71
Chain Sequence
MLQKKIEEIAAKYKHSVVKKCCYDGASVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system/inhibitor
molecule keywords COMPLEMENT 5A SEMI-SYNTHETIC ANTAGONIST
publication title Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding.
pubmed rcsb
source organism Homo sapiens
total genus 14
structure length 71
sequence length 71
ec nomenclature
pdb deposition date 1996-09-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01821 ANATO Anaphylotoxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.91.20 Mainly Alpha Up-down Bundle Influenza Virus Matrix Protein; Chain A, domain 1 Anaphylotoxins (complement system) 1cfaA00
4P3BA 4WB2A 1CFAA 4HW5A 3HQAA 4I6OA 3HQBA 4P39A 4WB3A 3CU7A 4FXKB 4P3AA 4HWJA 2B39A 5B4PB 1C5AA 1KJSA 5JPNB 4UU9C 3KLSA 2A73B
chains in the Genus database with same CATH superfamily
5JPMB 4P3BA 4WB2A 1CFAA 4HW5A 3HQAA 4I6OA 1AA7A 4D9JA 3HQBA 4ITVA 4P39A 4WB3A 3CU7A 4FXKB 4P3AA 4HWJA 2B39A 3VDXA 2Z16A 5B4PB 1C5AA 4IQ4A 1KJSA 5JPNB 5CQEA 3MD2A 4UU9C 4PUSA 1EA3A 3KLSA 2A73B 4FXGB
chains in the Genus database with same CATH topology
4P3BA 4WB2A 1CFAA 4HW5A 3HQAA 4I6OA 3HQBA 4P39A 4WB3A 3CU7A 4FXKB 4P3AA 4HWJA 2B39A 5B4PB 1C5AA 1KJSA 5JPNB 4UU9C 3KLSA 2A73B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4P3B A;  4WB2 A;  1CFA A;  4HW5 A;  3HQA A;  4I6O A;  3HQB A;  4P39 A;  4WB3 A;  3CU7 A;  4FXK B;  4P3A A;  4HWJ A;  2B39 A;  5B4P B;  1C5A A;  1KJS A;  5JPN B;  4UU9 C;  3KLS A;  2A73 B; 
#chains in the Genus database with same CATH topology
 5JPM B;  4P3B A;  4WB2 A;  1CFA A;  4HW5 A;  3HQA A;  4I6O A;  1AA7 A;  4D9J A;  3HQB A;  4ITV A;  4P39 A;  4WB3 A;  3CU7 A;  4FXK B;  4P3A A;  4HWJ A;  2B39 A;  3VDX A;  2Z16 A;  5B4P B;  1C5A A;  4IQ4 A;  1KJS A;  5JPN B;  5CQE A;  3MD2 A;  4UU9 C;  4PUS A;  1EA3 A;  3KLS A;  2A73 B;  4FXG B; 
#chains in the Genus database with same CATH homology
 4P3B A;  4WB2 A;  1CFA A;  4HW5 A;  3HQA A;  4I6O A;  3HQB A;  4P39 A;  4WB3 A;  3CU7 A;  4FXK B;  4P3A A;  4HWJ A;  2B39 A;  5B4P B;  1C5A A;  1KJS A;  5JPN B;  4UU9 C;  3KLS A;  2A73 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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