1ED9A

Structure of e. coli alkaline phosphatase without the inorganic phosphate at 1.75a resolution
Total Genus 167
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
167
Knots found
sequence length
449
structure length
449
Chain Sequence
b'TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
molecule tags Hydrolase
source organism Escherichia coli
publication title A revised mechanism for the alkaline phosphatase reaction involving three metal ions.
pubmed doi rcsb
total genus 167
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-01-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ed9A00
1ZEFA 1N2LA 5K4PA 4LRBA 1ZEDA 3BDGA 1AJAA 4ZGAA 3DYCA 3B5QA 4ZG6A 2IUCB 4LRAA 1ALIA 2D1GA 1N2KA 5GRRA 2XRGA 4KAVA 4CYRA 4GTZA 2XR9A 4KM4A 3LXQA 4KJGA 5DLTA 1EQJA 4UPLA 1P49A 3ED4A 3MK2A 1ELZA 4UOOA 1Y6VA 4LR9A 3A52A 1KH4A 3DPCA 1EI6A 1EW9A 3NKPA 5DLVA 1SHNA 1URAA 4YR1A 5L0KA 2W5XA 1ALKA 2W8SA 3CMRA 4QAXA 3Q3QA 2W5VA 1URBA 1KHNA 4UPKA 5IJSA 4FDJA 1AJCA 3MK0A 1EW8A 1KH9A 4KAYA 3TG0A 2W5WA 2RH6A 2GA3A 3T01A 4LQYA 3M8YA 3T00A 3WAYA 1ED9A 1E2SP 2VQRA 1AUKA 5HRTA 1KHLA 3M8ZA 2QZUA 3NKQA 2X98A 3KD8A 1O99A 4MY4A 3M8WA 1ZEBA 1ELYA 3UO0A 3MK1A 4CXUA 5LRNA 1ELXA 4LRCA 3NKNA 1KH5A 2G9YA 3OT9A 3T02A 3SZZA 3WAWA 1HDHA 2GSUA 2GSNA 4LR2A 1ALHA 4NWXA 3NKRA 3WBHA 3WAXA 4MHXA 3M7VA 1HQAA 4LR7A 3TX0A 5KXAA 2GLQA 4UPHA 5AJ9A 5L0EA 2W5QA 1Y7AA 3IGYB 4LRFA 1E1ZP 4ZG7A 4N7TA 3IGZB 5LRMA 5GOVA 5IJQA 3BDHA 1KHKA 2IFYA 3UNYA 3BDGB 4TN0A 4LRDA 4CYSA 4LREA 1B8JA 2ANHA 4UORA 4UPIA 1E3CP 1ANIA 1O98A 1KHJA 4UOPA 3E2DA 1ALJA 2W5SA 3TWZA 3NKOA 5C66A 3NKMA 4MIVA 1AJDA 5LQQA 4B56A 5EGHA 1HJKA 1ED8A 5EGEA 4GTXA 3UN5A 4CXKA 3BDFA 1FSUA 1KH7A 5DLWA 3NVLA 2W5TA 1K7HA 4NWJA 5L0BA 1AJBA 4GTYA 4GTWA 4LR8A 3UN2A 1E33P 2IUCA 4KJDA 1ANJA 2GSOA 3IDDA 2ZKTA 4FDIA 3WAVA 1SHQA 4CXSA 5INHA 3SZYA 2W5RA 3UN3A 5TJ3A 4ZG9A 1EJJA 2W8DA 1EW2A 5LIAA
chains in the Genus database with same CATH superfamily
1ZEFA 1N2LA 5K4PA 4LRBA 1ZEDA 3BDGA 1AJAA 4ZGAA 3DYCA 3B5QA 4ZG6A 2IUCB 4LRAA 1ALIA 2D1GA 1N2KA 5GRRA 2XRGA 4KAVA 4CYRA 4GTZA 2XR9A 4KM4A 3LXQA 4KJGA 5DLTA 1EQJA 4UPLA 1P49A 3ED4A 3MK2A 1ELZA 4UOOA 1Y6VA 4LR9A 3A52A 1KH4A 3DPCA 1EI6A 1EW9A 3NKPA 5DLVA 1SHNA 1URAA 4YR1A 5L0KA 2W5XA 1ALKA 2W8SA 3CMRA 4QAXA 3Q3QA 2W5VA 1URBA 1KHNA 4UPKA 5IJSA 4FDJA 1AJCA 3MK0A 1EW8A 1KH9A 4KAYA 3TG0A 2W5WA 2RH6A 2GA3A 3T01A 4LQYA 3M8YA 3T00A 3WAYA 1ED9A 1E2SP 2VQRA 1AUKA 5HRTA 1KHLA 3M8ZA 2QZUA 3NKQA 2X98A 3KD8A 1O99A 4MY4A 3M8WA 1ZEBA 1ELYA 3UO0A 3MK1A 4CXUA 5LRNA 1ELXA 4LRCA 3NKNA 1KH5A 2G9YA 3OT9A 3T02A 3SZZA 3WAWA 1HDHA 2GSUA 2GSNA 4LR2A 1ALHA 4NWXA 3NKRA 3WBHA 3WAXA 4MHXA 3M7VA 1HQAA 4LR7A 3TX0A 5KXAA 2GLQA 4UPHA 5AJ9A 5L0EA 2W5QA 1Y7AA 3IGYB 4LRFA 1E1ZP 4ZG7A 4N7TA 3IGZB 5LRMA 5GOVA 5IJQA 3BDHA 1KHKA 2IFYA 3UNYA 3BDGB 4TN0A 4LRDA 4CYSA 4LREA 1B8JA 2ANHA 4UORA 4UPIA 1E3CP 1ANIA 1O98A 1KHJA 4UOPA 3E2DA 1ALJA 2W5SA 3TWZA 3NKOA 5C66A 3NKMA 4MIVA 1AJDA 5LQQA 4B56A 5EGHA 1HJKA 1ED8A 5EGEA 4GTXA 3UN5A 4CXKA 3BDFA 1FSUA 1KH7A 5DLWA 3NVLA 2W5TA 1K7HA 4NWJA 5L0BA 1AJBA 4GTYA 4GTWA 4LR8A 3UN2A 1E33P 2IUCA 4KJDA 1ANJA 2GSOA 3IDDA 2ZKTA 4FDIA 3WAVA 1SHQA 4CXSA 5INHA 3SZYA 2W5RA 3UN3A 5TJ3A 4ZG9A 1EJJA 2W8DA 1EW2A 5LIAA
chains in the Genus database with same CATH topology
1ZEFA 1N2LA 5K4PA 4LRBA 1ZEDA 3BDGA 1AJAA 4ZGAA 3DYCA 3B5QA 4ZG6A 2IUCB 4LRAA 1ALIA 2D1GA 1N2KA 5GRRA 2XRGA 4KAVA 4CYRA 4GTZA 2XR9A 4KM4A 3LXQA 4KJGA 5DLTA 1EQJA 4UPLA 1P49A 3ED4A 3MK2A 1ELZA 4UOOA 1Y6VA 4LR9A 3A52A 1KH4A 3DPCA 1EI6A 1EW9A 3NKPA 5DLVA 1SHNA 1URAA 4YR1A 5L0KA 2W5XA 1ALKA 2W8SA 3CMRA 4QAXA 3Q3QA 2W5VA 1URBA 1KHNA 4UPKA 5IJSA 4FDJA 1AJCA 3MK0A 1EW8A 1KH9A 4KAYA 3TG0A 2W5WA 2RH6A 2GA3A 3T01A 4LQYA 3M8YA 3T00A 3WAYA 1ED9A 1E2SP 2VQRA 1AUKA 5HRTA 1KHLA 3M8ZA 2QZUA 3NKQA 2X98A 3KD8A 1O99A 4MY4A 3M8WA 1ZEBA 1ELYA 3UO0A 3MK1A 4CXUA 5LRNA 1ELXA 4LRCA 3NKNA 1KH5A 2G9YA 3OT9A 3T02A 3SZZA 3WAWA 1HDHA 2GSUA 2GSNA 4LR2A 1ALHA 4NWXA 3NKRA 3WBHA 3WAXA 4MHXA 3M7VA 1HQAA 4LR7A 3TX0A 5KXAA 2GLQA 4UPHA 5AJ9A 5L0EA 2W5QA 1Y7AA 3IGYB 4LRFA 1E1ZP 4ZG7A 4N7TA 3IGZB 5LRMA 5GOVA 5IJQA 3BDHA 1KHKA 2IFYA 3UNYA 3BDGB 4TN0A 4LRDA 4CYSA 4LREA 1B8JA 2ANHA 4UORA 4UPIA 1E3CP 1ANIA 1O98A 1KHJA 4UOPA 3E2DA 1ALJA 2W5SA 3TWZA 3NKOA 5C66A 3NKMA 4MIVA 1AJDA 5LQQA 4B56A 5EGHA 1HJKA 1ED8A 5EGEA 4GTXA 3UN5A 4CXKA 3BDFA 1FSUA 1KH7A 5DLWA 3NVLA 2W5TA 1K7HA 4NWJA 5L0BA 1AJBA 4GTYA 4GTWA 4LR8A 3UN2A 1E33P 2IUCA 4KJDA 1ANJA 2GSOA 3IDDA 2ZKTA 4FDIA 3WAVA 1SHQA 4CXSA 5INHA 3SZYA 2W5RA 3UN3A 5TJ3A 4ZG9A 1EJJA 2W8DA 1EW2A 5LIAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZEF A;  1N2L A;  5K4P A;  4LRB A;  1ZED A;  3BDG A;  1AJA A;  4ZGA A;  3DYC A;  3B5Q A;  4ZG6 A;  2IUC B;  4LRA A;  1ALI A;  2D1G A;  1N2K A;  5GRR A;  2XRG A;  4KAV A;  4CYR A;  4GTZ A;  2XR9 A;  4KM4 A;  3LXQ A;  4KJG A;  5DLT A;  1EQJ A;  4UPL A;  1P49 A;  3ED4 A;  3MK2 A;  1ELZ A;  4UOO A;  1Y6V A;  4LR9 A;  3A52 A;  1KH4 A;  3DPC A;  1EI6 A;  1EW9 A;  3NKP A;  5DLV A;  1SHN A;  1URA A;  4YR1 A;  5L0K A;  2W5X A;  1ALK A;  2W8S A;  3CMR A;  4QAX A;  3Q3Q A;  2W5V A;  1URB A;  1KHN A;  4UPK A;  5IJS A;  4FDJ A;  1AJC A;  3MK0 A;  1EW8 A;  1KH9 A;  4KAY A;  3TG0 A;  2W5W A;  2RH6 A;  2GA3 A;  3T01 A;  4LQY A;  3M8Y A;  3T00 A;  3WAY A;  1ED9 A;  1E2S P;  2VQR A;  1AUK A;  5HRT A;  1KHL A;  3M8Z A;  2QZU A;  3NKQ A;  2X98 A;  3KD8 A;  1O99 A;  4MY4 A;  3M8W A;  1ZEB A;  1ELY A;  3UO0 A;  3MK1 A;  4CXU A;  5LRN A;  1ELX A;  4LRC A;  3NKN A;  1KH5 A;  2G9Y A;  3OT9 A;  3T02 A;  3SZZ A;  3WAW A;  1HDH A;  2GSU A;  2GSN A;  4LR2 A;  1ALH A;  4NWX A;  3NKR A;  3WBH A;  3WAX A;  4MHX A;  3M7V A;  1HQA A;  4LR7 A;  3TX0 A;  5KXA A;  2GLQ A;  4UPH A;  5AJ9 A;  5L0E A;  2W5Q A;  1Y7A A;  3IGY B;  4LRF A;  1E1Z P;  4ZG7 A;  4N7T A;  3IGZ B;  5LRM A;  5GOV A;  5IJQ A;  3BDH A;  1KHK A;  2IFY A;  3UNY A;  3BDG B;  4TN0 A;  4LRD A;  4CYS A;  4LRE A;  1B8J A;  2ANH A;  4UOR A;  4UPI A;  1E3C P;  1ANI A;  1O98 A;  1KHJ A;  4UOP A;  3E2D A;  1ALJ A;  2W5S A;  3TWZ A;  3NKO A;  5C66 A;  3NKM A;  4MIV A;  1AJD A;  5LQQ A;  4B56 A;  5EGH A;  1HJK A;  1ED8 A;  5EGE A;  4GTX A;  3UN5 A;  4CXK A;  3BDF A;  1FSU A;  1KH7 A;  5DLW A;  3NVL A;  2W5T A;  1K7H A;  4NWJ A;  5L0B A;  1AJB A;  4GTY A;  4GTW A;  4LR8 A;  3UN2 A;  1E33 P;  2IUC A;  4KJD A;  1ANJ A;  2GSO A;  3IDD A;  2ZKT A;  4FDI A;  3WAV A;  1SHQ A;  4CXS A;  5INH A;  3SZY A;  2W5R A;  3UN3 A;  5TJ3 A;  4ZG9 A;  1EJJ A;  2W8D A;  1EW2 A;  5LIA A; 
#chains in the Genus database with same CATH topology
 1ZEF A;  1N2L A;  5K4P A;  4LRB A;  1ZED A;  3BDG A;  1AJA A;  4ZGA A;  3DYC A;  3B5Q A;  4ZG6 A;  2IUC B;  4LRA A;  1ALI A;  2D1G A;  1N2K A;  5GRR A;  2XRG A;  4KAV A;  4CYR A;  4GTZ A;  2XR9 A;  4KM4 A;  3LXQ A;  4KJG A;  5DLT A;  1EQJ A;  4UPL A;  1P49 A;  3ED4 A;  3MK2 A;  1ELZ A;  4UOO A;  1Y6V A;  4LR9 A;  3A52 A;  1KH4 A;  3DPC A;  1EI6 A;  1EW9 A;  3NKP A;  5DLV A;  1SHN A;  1URA A;  4YR1 A;  5L0K A;  2W5X A;  1ALK A;  2W8S A;  3CMR A;  4QAX A;  3Q3Q A;  2W5V A;  1URB A;  1KHN A;  4UPK A;  5IJS A;  4FDJ A;  1AJC A;  3MK0 A;  1EW8 A;  1KH9 A;  4KAY A;  3TG0 A;  2W5W A;  2RH6 A;  2GA3 A;  3T01 A;  4LQY A;  3M8Y A;  3T00 A;  3WAY A;  1ED9 A;  1E2S P;  2VQR A;  1AUK A;  5HRT A;  1KHL A;  3M8Z A;  2QZU A;  3NKQ A;  2X98 A;  3KD8 A;  1O99 A;  4MY4 A;  3M8W A;  1ZEB A;  1ELY A;  3UO0 A;  3MK1 A;  4CXU A;  5LRN A;  1ELX A;  4LRC A;  3NKN A;  1KH5 A;  2G9Y A;  3OT9 A;  3T02 A;  3SZZ A;  3WAW A;  1HDH A;  2GSU A;  2GSN A;  4LR2 A;  1ALH A;  4NWX A;  3NKR A;  3WBH A;  3WAX A;  4MHX A;  3M7V A;  1HQA A;  4LR7 A;  3TX0 A;  5KXA A;  2GLQ A;  4UPH A;  5AJ9 A;  5L0E A;  2W5Q A;  1Y7A A;  3IGY B;  4LRF A;  1E1Z P;  4ZG7 A;  4N7T A;  3IGZ B;  5LRM A;  5GOV A;  5IJQ A;  3BDH A;  1KHK A;  2IFY A;  3UNY A;  3BDG B;  4TN0 A;  4LRD A;  4CYS A;  4LRE A;  1B8J A;  2ANH A;  4UOR A;  4UPI A;  1E3C P;  1ANI A;  1O98 A;  1KHJ A;  4UOP A;  3E2D A;  1ALJ A;  2W5S A;  3TWZ A;  3NKO A;  5C66 A;  3NKM A;  4MIV A;  1AJD A;  5LQQ A;  4B56 A;  5EGH A;  1HJK A;  1ED8 A;  5EGE A;  4GTX A;  3UN5 A;  4CXK A;  3BDF A;  1FSU A;  1KH7 A;  5DLW A;  3NVL A;  2W5T A;  1K7H A;  4NWJ A;  5L0B A;  1AJB A;  4GTY A;  4GTW A;  4LR8 A;  3UN2 A;  1E33 P;  2IUC A;  4KJD A;  1ANJ A;  2GSO A;  3IDD A;  2ZKT A;  4FDI A;  3WAV A;  1SHQ A;  4CXS A;  5INH A;  3SZY A;  2W5R A;  3UN3 A;  5TJ3 A;  4ZG9 A;  1EJJ A;  2W8D A;  1EW2 A;  5LIA A; 
#chains in the Genus database with same CATH homology
 1ZEF A;  1N2L A;  5K4P A;  4LRB A;  1ZED A;  3BDG A;  1AJA A;  4ZGA A;  3DYC A;  3B5Q A;  4ZG6 A;  2IUC B;  4LRA A;  1ALI A;  2D1G A;  1N2K A;  5GRR A;  2XRG A;  4KAV A;  4CYR A;  4GTZ A;  2XR9 A;  4KM4 A;  3LXQ A;  4KJG A;  5DLT A;  1EQJ A;  4UPL A;  1P49 A;  3ED4 A;  3MK2 A;  1ELZ A;  4UOO A;  1Y6V A;  4LR9 A;  3A52 A;  1KH4 A;  3DPC A;  1EI6 A;  1EW9 A;  3NKP A;  5DLV A;  1SHN A;  1URA A;  4YR1 A;  5L0K A;  2W5X A;  1ALK A;  2W8S A;  3CMR A;  4QAX A;  3Q3Q A;  2W5V A;  1URB A;  1KHN A;  4UPK A;  5IJS A;  4FDJ A;  1AJC A;  3MK0 A;  1EW8 A;  1KH9 A;  4KAY A;  3TG0 A;  2W5W A;  2RH6 A;  2GA3 A;  3T01 A;  4LQY A;  3M8Y A;  3T00 A;  3WAY A;  1ED9 A;  1E2S P;  2VQR A;  1AUK A;  5HRT A;  1KHL A;  3M8Z A;  2QZU A;  3NKQ A;  2X98 A;  3KD8 A;  1O99 A;  4MY4 A;  3M8W A;  1ZEB A;  1ELY A;  3UO0 A;  3MK1 A;  4CXU A;  5LRN A;  1ELX A;  4LRC A;  3NKN A;  1KH5 A;  2G9Y A;  3OT9 A;  3T02 A;  3SZZ A;  3WAW A;  1HDH A;  2GSU A;  2GSN A;  4LR2 A;  1ALH A;  4NWX A;  3NKR A;  3WBH A;  3WAX A;  4MHX A;  3M7V A;  1HQA A;  4LR7 A;  3TX0 A;  5KXA A;  2GLQ A;  4UPH A;  5AJ9 A;  5L0E A;  2W5Q A;  1Y7A A;  3IGY B;  4LRF A;  1E1Z P;  4ZG7 A;  4N7T A;  3IGZ B;  5LRM A;  5GOV A;  5IJQ A;  3BDH A;  1KHK A;  2IFY A;  3UNY A;  3BDG B;  4TN0 A;  4LRD A;  4CYS A;  4LRE A;  1B8J A;  2ANH A;  4UOR A;  4UPI A;  1E3C P;  1ANI A;  1O98 A;  1KHJ A;  4UOP A;  3E2D A;  1ALJ A;  2W5S A;  3TWZ A;  3NKO A;  5C66 A;  3NKM A;  4MIV A;  1AJD A;  5LQQ A;  4B56 A;  5EGH A;  1HJK A;  1ED8 A;  5EGE A;  4GTX A;  3UN5 A;  4CXK A;  3BDF A;  1FSU A;  1KH7 A;  5DLW A;  3NVL A;  2W5T A;  1K7H A;  4NWJ A;  5L0B A;  1AJB A;  4GTY A;  4GTW A;  4LR8 A;  3UN2 A;  1E33 P;  2IUC A;  4KJD A;  1ANJ A;  2GSO A;  3IDD A;  2ZKT A;  4FDI A;  3WAV A;  1SHQ A;  4CXS A;  5INH A;  3SZY A;  2W5R A;  3UN3 A;  5TJ3 A;  4ZG9 A;  1EJJ A;  2W8D A;  1EW2 A;  5LIA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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