1ELXA

E. coli alkaline phosphatase mutant (s102a)
Total Genus 153
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
153
Knots found
sequence length
449
structure length
449
Chain Sequence
b'TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: insights into the catalytic mechanism without the nucleophile Ser102.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 153
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1998-02-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1elxA00
2VQRA 5L0EA 4UORA 3BDHA 1AJCA 1EW9A 4UPLA 3BDGB 4CYSA 4LR9A 4FDIA 1ELZA 3NKOA 4UOPA 1EW8A 5LIAA 1HJKA 1N2KA 3IDDA 4LR7A 4GTWA 4LREA 5LQQA 3TWZA 4LQYA 1ZEDA 2W5SA 3BDGA 4UPHA 4KAYA 3NKMA 4ZG9A 4LRDA 3UO0A 4YR1A 4GTYA 2G9YA 3B5QA 4TN0A 5LRMA 1HQAA 1ALHA 2W5RA 3A52A 5GOVA 5DLWA 1ZEBA 2ZKTA 3UN2A 3TG0A 2GSOA 3BDFA 3IGYB 4LRCA 5GRRA 4CXUA 2IUCB 3UNYA 1ALJA 1K7HA 1KH4A 5EGEA 5INHA 5KXAA 4LR2A 1KHKA 3NKQA 3WBHA 2D1GA 1KH7A 3M8ZA 1E1ZP 5L0BA 3NVLA 2GA3A 1ELXA 1E33P 5DLVA 5HRTA 1EQJA 1KH9A 3TX0A 3MK2A 2W5WA 1URAA 2GLQA 4LRFA 3IGZB 1EW2A 1ELYA 1B8JA 1KHLA 1SHQA 3T02A 3WAYA 4ZGAA 2W8SA 1KHJA 1SHNA 4GTXA 1ALIA 1AJAA 1KHNA 5IJSA 4UOOA 3E2DA 5TJ3A 4KAVA 3NKRA 5EGHA 5DLTA 3OT9A 1AJBA 4N7TA 5AJ9A 5LRNA 2IUCA 3M7VA 1ANIA 2W8DA 3UN5A 4NWJA 4KJGA 4LRAA 1ZEFA 4QAXA 2W5QA 3WAVA 1O98A 4UPKA 3MK0A 1N2LA 3M8WA 4MIVA 5C66A 3ED4A 3SZYA 3UN3A 4B56A 4ZG6A 1ANJA 1O99A 2QZUA 1P49A 3NKPA 4KJDA 3LXQA 3DYCA 1Y6VA 4FDJA 1FSUA 1E3CP 4LRBA 3WAWA 2W5VA 3WAXA 1ALKA 4NWXA 5L0KA 1KH5A 1E2SP 1EI6A 4CXSA 2GSNA 3NKNA 2RH6A 4LR8A 3DPCA 4CXKA 2X98A 2XRGA 1AJDA 1AUKA 3T00A 3T01A 3CMRA 4MHXA 5K4PA 1ED8A 1HDHA 3SZZA 5IJQA 1EJJA 1ED9A 3Q3QA 4UPIA 2W5TA 2IFYA 3KD8A 4CYRA 4MY4A 1Y7AA 2W5XA 3M8YA 2GSUA 4GTZA 4ZG7A 2ANHA 4KM4A 3MK1A 2XR9A 1URBA
chains in the Genus database with same CATH superfamily
2VQRA 5L0EA 4UORA 3BDHA 1AJCA 1EW9A 4UPLA 3BDGB 4CYSA 4LR9A 4FDIA 1ELZA 3NKOA 4UOPA 1EW8A 5LIAA 1HJKA 1N2KA 3IDDA 4LR7A 4GTWA 4LREA 5LQQA 3TWZA 4LQYA 1ZEDA 2W5SA 3BDGA 4UPHA 4KAYA 3NKMA 4ZG9A 4LRDA 3UO0A 4YR1A 4GTYA 2G9YA 3B5QA 4TN0A 5LRMA 1HQAA 1ALHA 2W5RA 3A52A 5GOVA 5DLWA 1ZEBA 2ZKTA 3UN2A 3TG0A 2GSOA 3BDFA 3IGYB 4LRCA 5GRRA 4CXUA 2IUCB 3UNYA 1ALJA 1K7HA 1KH4A 5EGEA 5INHA 5KXAA 4LR2A 1KHKA 3NKQA 3WBHA 2D1GA 1KH7A 3M8ZA 1E1ZP 5L0BA 3NVLA 2GA3A 1ELXA 1E33P 5DLVA 5HRTA 1EQJA 1KH9A 3TX0A 3MK2A 2W5WA 1URAA 2GLQA 4LRFA 3IGZB 1EW2A 1ELYA 1B8JA 1KHLA 1SHQA 3T02A 3WAYA 4ZGAA 2W8SA 1KHJA 1SHNA 4GTXA 1ALIA 1AJAA 1KHNA 5IJSA 4UOOA 3E2DA 5TJ3A 4KAVA 3NKRA 5EGHA 5DLTA 3OT9A 1AJBA 4N7TA 5AJ9A 5LRNA 2IUCA 3M7VA 1ANIA 2W8DA 3UN5A 4NWJA 4KJGA 4LRAA 1ZEFA 4QAXA 2W5QA 3WAVA 1O98A 4UPKA 3MK0A 1N2LA 3M8WA 4MIVA 5C66A 3ED4A 3SZYA 3UN3A 4B56A 4ZG6A 1ANJA 1O99A 2QZUA 1P49A 3NKPA 4KJDA 3LXQA 3DYCA 1Y6VA 4FDJA 1FSUA 1E3CP 4LRBA 3WAWA 2W5VA 3WAXA 1ALKA 4NWXA 5L0KA 1KH5A 1E2SP 1EI6A 4CXSA 2GSNA 3NKNA 2RH6A 4LR8A 3DPCA 4CXKA 2X98A 2XRGA 1AJDA 1AUKA 3T00A 3T01A 3CMRA 4MHXA 5K4PA 1ED8A 1HDHA 3SZZA 5IJQA 1EJJA 1ED9A 3Q3QA 4UPIA 2W5TA 2IFYA 3KD8A 4CYRA 4MY4A 1Y7AA 2W5XA 3M8YA 2GSUA 4GTZA 4ZG7A 2ANHA 4KM4A 3MK1A 2XR9A 1URBA
chains in the Genus database with same CATH topology
2VQRA 5L0EA 4UORA 3BDHA 1AJCA 1EW9A 4UPLA 3BDGB 4CYSA 4LR9A 4FDIA 1ELZA 3NKOA 4UOPA 1EW8A 5LIAA 1HJKA 1N2KA 3IDDA 4LR7A 4GTWA 4LREA 5LQQA 3TWZA 4LQYA 1ZEDA 2W5SA 3BDGA 4UPHA 4KAYA 3NKMA 4ZG9A 4LRDA 3UO0A 4YR1A 4GTYA 2G9YA 3B5QA 4TN0A 5LRMA 1HQAA 1ALHA 2W5RA 3A52A 5GOVA 5DLWA 1ZEBA 2ZKTA 3UN2A 3TG0A 2GSOA 3BDFA 3IGYB 4LRCA 5GRRA 4CXUA 2IUCB 3UNYA 1ALJA 1K7HA 1KH4A 5EGEA 5INHA 5KXAA 4LR2A 1KHKA 3NKQA 3WBHA 2D1GA 1KH7A 3M8ZA 1E1ZP 5L0BA 3NVLA 2GA3A 1ELXA 1E33P 5DLVA 5HRTA 1EQJA 1KH9A 3TX0A 3MK2A 2W5WA 1URAA 2GLQA 4LRFA 3IGZB 1EW2A 1ELYA 1B8JA 1KHLA 1SHQA 3T02A 3WAYA 4ZGAA 2W8SA 1KHJA 1SHNA 4GTXA 1ALIA 1AJAA 1KHNA 5IJSA 4UOOA 3E2DA 5TJ3A 4KAVA 3NKRA 5EGHA 5DLTA 3OT9A 1AJBA 4N7TA 5AJ9A 5LRNA 2IUCA 3M7VA 1ANIA 2W8DA 3UN5A 4NWJA 4KJGA 4LRAA 1ZEFA 4QAXA 2W5QA 3WAVA 1O98A 4UPKA 3MK0A 1N2LA 3M8WA 4MIVA 5C66A 3ED4A 3SZYA 3UN3A 4B56A 4ZG6A 1ANJA 1O99A 2QZUA 1P49A 3NKPA 4KJDA 3LXQA 3DYCA 1Y6VA 4FDJA 1FSUA 1E3CP 4LRBA 3WAWA 2W5VA 3WAXA 1ALKA 4NWXA 5L0KA 1KH5A 1E2SP 1EI6A 4CXSA 2GSNA 3NKNA 2RH6A 4LR8A 3DPCA 4CXKA 2X98A 2XRGA 1AJDA 1AUKA 3T00A 3T01A 3CMRA 4MHXA 5K4PA 1ED8A 1HDHA 3SZZA 5IJQA 1EJJA 1ED9A 3Q3QA 4UPIA 2W5TA 2IFYA 3KD8A 4CYRA 4MY4A 1Y7AA 2W5XA 3M8YA 2GSUA 4GTZA 4ZG7A 2ANHA 4KM4A 3MK1A 2XR9A 1URBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VQR A;  5L0E A;  4UOR A;  3BDH A;  1AJC A;  1EW9 A;  4UPL A;  3BDG B;  4CYS A;  4LR9 A;  4FDI A;  1ELZ A;  3NKO A;  4UOP A;  1EW8 A;  5LIA A;  1HJK A;  1N2K A;  3IDD A;  4LR7 A;  4GTW A;  4LRE A;  5LQQ A;  3TWZ A;  4LQY A;  1ZED A;  2W5S A;  3BDG A;  4UPH A;  4KAY A;  3NKM A;  4ZG9 A;  4LRD A;  3UO0 A;  4YR1 A;  4GTY A;  2G9Y A;  3B5Q A;  4TN0 A;  5LRM A;  1HQA A;  1ALH A;  2W5R A;  3A52 A;  5GOV A;  5DLW A;  1ZEB A;  2ZKT A;  3UN2 A;  3TG0 A;  2GSO A;  3BDF A;  3IGY B;  4LRC A;  5GRR A;  4CXU A;  2IUC B;  3UNY A;  1ALJ A;  1K7H A;  1KH4 A;  5EGE A;  5INH A;  5KXA A;  4LR2 A;  1KHK A;  3NKQ A;  3WBH A;  2D1G A;  1KH7 A;  3M8Z A;  1E1Z P;  5L0B A;  3NVL A;  2GA3 A;  1ELX A;  1E33 P;  5DLV A;  5HRT A;  1EQJ A;  1KH9 A;  3TX0 A;  3MK2 A;  2W5W A;  1URA A;  2GLQ A;  4LRF A;  3IGZ B;  1EW2 A;  1ELY A;  1B8J A;  1KHL A;  1SHQ A;  3T02 A;  3WAY A;  4ZGA A;  2W8S A;  1KHJ A;  1SHN A;  4GTX A;  1ALI A;  1AJA A;  1KHN A;  5IJS A;  4UOO A;  3E2D A;  5TJ3 A;  4KAV A;  3NKR A;  5EGH A;  5DLT A;  3OT9 A;  1AJB A;  4N7T A;  5AJ9 A;  5LRN A;  2IUC A;  3M7V A;  1ANI A;  2W8D A;  3UN5 A;  4NWJ A;  4KJG A;  4LRA A;  1ZEF A;  4QAX A;  2W5Q A;  3WAV A;  1O98 A;  4UPK A;  3MK0 A;  1N2L A;  3M8W A;  4MIV A;  5C66 A;  3ED4 A;  3SZY A;  3UN3 A;  4B56 A;  4ZG6 A;  1ANJ A;  1O99 A;  2QZU A;  1P49 A;  3NKP A;  4KJD A;  3LXQ A;  3DYC A;  1Y6V A;  4FDJ A;  1FSU A;  1E3C P;  4LRB A;  3WAW A;  2W5V A;  3WAX A;  1ALK A;  4NWX A;  5L0K A;  1KH5 A;  1E2S P;  1EI6 A;  4CXS A;  2GSN A;  3NKN A;  2RH6 A;  4LR8 A;  3DPC A;  4CXK A;  2X98 A;  2XRG A;  1AJD A;  1AUK A;  3T00 A;  3T01 A;  3CMR A;  4MHX A;  5K4P A;  1ED8 A;  1HDH A;  3SZZ A;  5IJQ A;  1EJJ A;  1ED9 A;  3Q3Q A;  4UPI A;  2W5T A;  2IFY A;  3KD8 A;  4CYR A;  4MY4 A;  1Y7A A;  2W5X A;  3M8Y A;  2GSU A;  4GTZ A;  4ZG7 A;  2ANH A;  4KM4 A;  3MK1 A;  2XR9 A;  1URB A; 
#chains in the Genus database with same CATH topology
 2VQR A;  5L0E A;  4UOR A;  3BDH A;  1AJC A;  1EW9 A;  4UPL A;  3BDG B;  4CYS A;  4LR9 A;  4FDI A;  1ELZ A;  3NKO A;  4UOP A;  1EW8 A;  5LIA A;  1HJK A;  1N2K A;  3IDD A;  4LR7 A;  4GTW A;  4LRE A;  5LQQ A;  3TWZ A;  4LQY A;  1ZED A;  2W5S A;  3BDG A;  4UPH A;  4KAY A;  3NKM A;  4ZG9 A;  4LRD A;  3UO0 A;  4YR1 A;  4GTY A;  2G9Y A;  3B5Q A;  4TN0 A;  5LRM A;  1HQA A;  1ALH A;  2W5R A;  3A52 A;  5GOV A;  5DLW A;  1ZEB A;  2ZKT A;  3UN2 A;  3TG0 A;  2GSO A;  3BDF A;  3IGY B;  4LRC A;  5GRR A;  4CXU A;  2IUC B;  3UNY A;  1ALJ A;  1K7H A;  1KH4 A;  5EGE A;  5INH A;  5KXA A;  4LR2 A;  1KHK A;  3NKQ A;  3WBH A;  2D1G A;  1KH7 A;  3M8Z A;  1E1Z P;  5L0B A;  3NVL A;  2GA3 A;  1ELX A;  1E33 P;  5DLV A;  5HRT A;  1EQJ A;  1KH9 A;  3TX0 A;  3MK2 A;  2W5W A;  1URA A;  2GLQ A;  4LRF A;  3IGZ B;  1EW2 A;  1ELY A;  1B8J A;  1KHL A;  1SHQ A;  3T02 A;  3WAY A;  4ZGA A;  2W8S A;  1KHJ A;  1SHN A;  4GTX A;  1ALI A;  1AJA A;  1KHN A;  5IJS A;  4UOO A;  3E2D A;  5TJ3 A;  4KAV A;  3NKR A;  5EGH A;  5DLT A;  3OT9 A;  1AJB A;  4N7T A;  5AJ9 A;  5LRN A;  2IUC A;  3M7V A;  1ANI A;  2W8D A;  3UN5 A;  4NWJ A;  4KJG A;  4LRA A;  1ZEF A;  4QAX A;  2W5Q A;  3WAV A;  1O98 A;  4UPK A;  3MK0 A;  1N2L A;  3M8W A;  4MIV A;  5C66 A;  3ED4 A;  3SZY A;  3UN3 A;  4B56 A;  4ZG6 A;  1ANJ A;  1O99 A;  2QZU A;  1P49 A;  3NKP A;  4KJD A;  3LXQ A;  3DYC A;  1Y6V A;  4FDJ A;  1FSU A;  1E3C P;  4LRB A;  3WAW A;  2W5V A;  3WAX A;  1ALK A;  4NWX A;  5L0K A;  1KH5 A;  1E2S P;  1EI6 A;  4CXS A;  2GSN A;  3NKN A;  2RH6 A;  4LR8 A;  3DPC A;  4CXK A;  2X98 A;  2XRG A;  1AJD A;  1AUK A;  3T00 A;  3T01 A;  3CMR A;  4MHX A;  5K4P A;  1ED8 A;  1HDH A;  3SZZ A;  5IJQ A;  1EJJ A;  1ED9 A;  3Q3Q A;  4UPI A;  2W5T A;  2IFY A;  3KD8 A;  4CYR A;  4MY4 A;  1Y7A A;  2W5X A;  3M8Y A;  2GSU A;  4GTZ A;  4ZG7 A;  2ANH A;  4KM4 A;  3MK1 A;  2XR9 A;  1URB A; 
#chains in the Genus database with same CATH homology
 2VQR A;  5L0E A;  4UOR A;  3BDH A;  1AJC A;  1EW9 A;  4UPL A;  3BDG B;  4CYS A;  4LR9 A;  4FDI A;  1ELZ A;  3NKO A;  4UOP A;  1EW8 A;  5LIA A;  1HJK A;  1N2K A;  3IDD A;  4LR7 A;  4GTW A;  4LRE A;  5LQQ A;  3TWZ A;  4LQY A;  1ZED A;  2W5S A;  3BDG A;  4UPH A;  4KAY A;  3NKM A;  4ZG9 A;  4LRD A;  3UO0 A;  4YR1 A;  4GTY A;  2G9Y A;  3B5Q A;  4TN0 A;  5LRM A;  1HQA A;  1ALH A;  2W5R A;  3A52 A;  5GOV A;  5DLW A;  1ZEB A;  2ZKT A;  3UN2 A;  3TG0 A;  2GSO A;  3BDF A;  3IGY B;  4LRC A;  5GRR A;  4CXU A;  2IUC B;  3UNY A;  1ALJ A;  1K7H A;  1KH4 A;  5EGE A;  5INH A;  5KXA A;  4LR2 A;  1KHK A;  3NKQ A;  3WBH A;  2D1G A;  1KH7 A;  3M8Z A;  1E1Z P;  5L0B A;  3NVL A;  2GA3 A;  1ELX A;  1E33 P;  5DLV A;  5HRT A;  1EQJ A;  1KH9 A;  3TX0 A;  3MK2 A;  2W5W A;  1URA A;  2GLQ A;  4LRF A;  3IGZ B;  1EW2 A;  1ELY A;  1B8J A;  1KHL A;  1SHQ A;  3T02 A;  3WAY A;  4ZGA A;  2W8S A;  1KHJ A;  1SHN A;  4GTX A;  1ALI A;  1AJA A;  1KHN A;  5IJS A;  4UOO A;  3E2D A;  5TJ3 A;  4KAV A;  3NKR A;  5EGH A;  5DLT A;  3OT9 A;  1AJB A;  4N7T A;  5AJ9 A;  5LRN A;  2IUC A;  3M7V A;  1ANI A;  2W8D A;  3UN5 A;  4NWJ A;  4KJG A;  4LRA A;  1ZEF A;  4QAX A;  2W5Q A;  3WAV A;  1O98 A;  4UPK A;  3MK0 A;  1N2L A;  3M8W A;  4MIV A;  5C66 A;  3ED4 A;  3SZY A;  3UN3 A;  4B56 A;  4ZG6 A;  1ANJ A;  1O99 A;  2QZU A;  1P49 A;  3NKP A;  4KJD A;  3LXQ A;  3DYC A;  1Y6V A;  4FDJ A;  1FSU A;  1E3C P;  4LRB A;  3WAW A;  2W5V A;  3WAX A;  1ALK A;  4NWX A;  5L0K A;  1KH5 A;  1E2S P;  1EI6 A;  4CXS A;  2GSN A;  3NKN A;  2RH6 A;  4LR8 A;  3DPC A;  4CXK A;  2X98 A;  2XRG A;  1AJD A;  1AUK A;  3T00 A;  3T01 A;  3CMR A;  4MHX A;  5K4P A;  1ED8 A;  1HDH A;  3SZZ A;  5IJQ A;  1EJJ A;  1ED9 A;  3Q3Q A;  4UPI A;  2W5T A;  2IFY A;  3KD8 A;  4CYR A;  4MY4 A;  1Y7A A;  2W5X A;  3M8Y A;  2GSU A;  4GTZ A;  4ZG7 A;  2ANH A;  4KM4 A;  3MK1 A;  2XR9 A;  1URB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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