1ELYA

E. coli alkaline phosphatase mutant (s102c)
Total Genus 157
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
157
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDCAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: insights into the catalytic mechanism without the nucleophile Ser102.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
total genus 157
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1998-02-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1elyA00
1ANIA 2IUCA 2W5VA 3BDFA 4UOPA 3NKMA 3NKPA 1ED9A 3T00A 4UPHA 2IUCB 2W8DA 5LQQA 2D1GA 4ZG6A 4CXSA 3BDGB 2W5WA 4LR9A 5DLVA 1KHJA 1KH4A 2GLQA 3M8YA 3NKRA 4YR1A 4GTYA 1KH9A 1AJDA 1ELXA 4ZG9A 1ZEBA 2RH6A 1EW8A 1SHQA 5IJQA 4CYRA 3KD8A 1URAA 1SHNA 1EJJA 3SZZA 1HQAA 3NKQA 1HDHA 2W8SA 1ELZA 5GRRA 1ANJA 1FSUA 1B8JA 1URBA 3OT9A 1EW2A 4FDJA 4LRDA 4UPKA 3DPCA 2GSUA 3BDHA 4CXUA 3TWZA 2G9YA 4LRFA 3NVLA 2XRGA 4KM4A 1Y6VA 1K7HA 2W5SA 4GTWA 1E33P 1ZEFA 3CMRA 4LRAA 5LIAA 1E1ZP 5L0KA 5LRNA 1EQJA 2QZUA 3UN2A 4B56A 3M8WA 1EI6A 4LR7A 4ZGAA 3IGYB 2GSNA 2XR9A 3T01A 3WAVA 3WBHA 4MY4A 1AJAA 1AJBA 3DYCA 1HJKA 4GTZA 5EGHA 5DLWA 1ALJA 2GA3A 5K4PA 3UO0A 3MK1A 1N2LA 4KJGA 5GOVA 2X98A 1KHKA 4KAYA 3Q3QA 2W5RA 3IGZB 4UOOA 3M7VA 4QAXA 3T02A 1AJCA 1O98A 3WAWA 5KXAA 3IDDA 3UN5A 3BDGA 4LQYA 3NKOA 4GTXA 5INHA 1KHLA 4KAVA 5LRMA 2VQRA 1Y7AA 4NWJA 1ALKA 2W5XA 4CYSA 3B5QA 4LRCA 5L0EA 1KHNA 4LREA 4FDIA 5IJSA 3TG0A 4MHXA 1E2SP 4LR2A 4LRBA 5DLTA 1KH7A 1EW9A 1N2KA 3NKNA 5C66A 5L0BA 4LR8A 2W5TA 4UORA 3A52A 2W5QA 5AJ9A 1E3CP 2GSOA 3MK0A 4N7TA 3UN3A 3WAXA 3TX0A 1ZEDA 3WAYA 1ALIA 1KH5A 1ELYA 4KJDA 5EGEA 4NWXA 2ANHA 2ZKTA 1AUKA 3UNYA 4ZG7A 1ED8A 4UPLA 2IFYA 4MIVA 3LXQA 3M8ZA 5HRTA 4CXKA 3ED4A 4TN0A 3E2DA 4UPIA 1O99A 5TJ3A 1ALHA 3SZYA 3MK2A 1P49A
chains in the Genus database with same CATH superfamily
1ANIA 2IUCA 2W5VA 3BDFA 4UOPA 3NKMA 3NKPA 1ED9A 3T00A 4UPHA 2IUCB 2W8DA 5LQQA 2D1GA 4ZG6A 4CXSA 3BDGB 2W5WA 4LR9A 5DLVA 1KHJA 1KH4A 2GLQA 3M8YA 3NKRA 4YR1A 4GTYA 1KH9A 1AJDA 1ELXA 4ZG9A 1ZEBA 2RH6A 1EW8A 1SHQA 5IJQA 4CYRA 3KD8A 1URAA 1SHNA 1EJJA 3SZZA 1HQAA 3NKQA 1HDHA 2W8SA 1ELZA 5GRRA 1ANJA 1FSUA 1B8JA 1URBA 3OT9A 1EW2A 4FDJA 4LRDA 4UPKA 3DPCA 2GSUA 3BDHA 4CXUA 3TWZA 2G9YA 4LRFA 3NVLA 2XRGA 4KM4A 1Y6VA 1K7HA 2W5SA 4GTWA 1E33P 1ZEFA 3CMRA 4LRAA 5LIAA 1E1ZP 5L0KA 5LRNA 1EQJA 2QZUA 3UN2A 4B56A 3M8WA 1EI6A 4LR7A 4ZGAA 3IGYB 2GSNA 2XR9A 3T01A 3WAVA 3WBHA 4MY4A 1AJAA 1AJBA 3DYCA 1HJKA 4GTZA 5EGHA 5DLWA 1ALJA 2GA3A 5K4PA 3UO0A 3MK1A 1N2LA 4KJGA 5GOVA 2X98A 1KHKA 4KAYA 3Q3QA 2W5RA 3IGZB 4UOOA 3M7VA 4QAXA 3T02A 1AJCA 1O98A 3WAWA 5KXAA 3IDDA 3UN5A 3BDGA 4LQYA 3NKOA 4GTXA 5INHA 1KHLA 4KAVA 5LRMA 2VQRA 1Y7AA 4NWJA 1ALKA 2W5XA 4CYSA 3B5QA 4LRCA 5L0EA 1KHNA 4LREA 4FDIA 5IJSA 3TG0A 4MHXA 1E2SP 4LR2A 4LRBA 5DLTA 1KH7A 1EW9A 1N2KA 3NKNA 5C66A 5L0BA 4LR8A 2W5TA 4UORA 3A52A 2W5QA 5AJ9A 1E3CP 2GSOA 3MK0A 4N7TA 3UN3A 3WAXA 3TX0A 1ZEDA 3WAYA 1ALIA 1KH5A 1ELYA 4KJDA 5EGEA 4NWXA 2ANHA 2ZKTA 1AUKA 3UNYA 4ZG7A 1ED8A 4UPLA 2IFYA 4MIVA 3LXQA 3M8ZA 5HRTA 4CXKA 3ED4A 4TN0A 3E2DA 4UPIA 1O99A 5TJ3A 1ALHA 3SZYA 3MK2A 1P49A
chains in the Genus database with same CATH topology
1ANIA 2IUCA 2W5VA 3BDFA 4UOPA 3NKMA 3NKPA 1ED9A 3T00A 4UPHA 2IUCB 2W8DA 5LQQA 2D1GA 4ZG6A 4CXSA 3BDGB 2W5WA 4LR9A 5DLVA 1KHJA 1KH4A 2GLQA 3M8YA 3NKRA 4YR1A 4GTYA 1KH9A 1AJDA 1ELXA 4ZG9A 1ZEBA 2RH6A 1EW8A 1SHQA 5IJQA 4CYRA 3KD8A 1URAA 1SHNA 1EJJA 3SZZA 1HQAA 3NKQA 1HDHA 2W8SA 1ELZA 5GRRA 1ANJA 1FSUA 1B8JA 1URBA 3OT9A 1EW2A 4FDJA 4LRDA 4UPKA 3DPCA 2GSUA 3BDHA 4CXUA 3TWZA 2G9YA 4LRFA 3NVLA 2XRGA 4KM4A 1Y6VA 1K7HA 2W5SA 4GTWA 1E33P 1ZEFA 3CMRA 4LRAA 5LIAA 1E1ZP 5L0KA 5LRNA 1EQJA 2QZUA 3UN2A 4B56A 3M8WA 1EI6A 4LR7A 4ZGAA 3IGYB 2GSNA 2XR9A 3T01A 3WAVA 3WBHA 4MY4A 1AJAA 1AJBA 3DYCA 1HJKA 4GTZA 5EGHA 5DLWA 1ALJA 2GA3A 5K4PA 3UO0A 3MK1A 1N2LA 4KJGA 5GOVA 2X98A 1KHKA 4KAYA 3Q3QA 2W5RA 3IGZB 4UOOA 3M7VA 4QAXA 3T02A 1AJCA 1O98A 3WAWA 5KXAA 3IDDA 3UN5A 3BDGA 4LQYA 3NKOA 4GTXA 5INHA 1KHLA 4KAVA 5LRMA 2VQRA 1Y7AA 4NWJA 1ALKA 2W5XA 4CYSA 3B5QA 4LRCA 5L0EA 1KHNA 4LREA 4FDIA 5IJSA 3TG0A 4MHXA 1E2SP 4LR2A 4LRBA 5DLTA 1KH7A 1EW9A 1N2KA 3NKNA 5C66A 5L0BA 4LR8A 2W5TA 4UORA 3A52A 2W5QA 5AJ9A 1E3CP 2GSOA 3MK0A 4N7TA 3UN3A 3WAXA 3TX0A 1ZEDA 3WAYA 1ALIA 1KH5A 1ELYA 4KJDA 5EGEA 4NWXA 2ANHA 2ZKTA 1AUKA 3UNYA 4ZG7A 1ED8A 4UPLA 2IFYA 4MIVA 3LXQA 3M8ZA 5HRTA 4CXKA 3ED4A 4TN0A 3E2DA 4UPIA 1O99A 5TJ3A 1ALHA 3SZYA 3MK2A 1P49A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ANI A;  2IUC A;  2W5V A;  3BDF A;  4UOP A;  3NKM A;  3NKP A;  1ED9 A;  3T00 A;  4UPH A;  2IUC B;  2W8D A;  5LQQ A;  2D1G A;  4ZG6 A;  4CXS A;  3BDG B;  2W5W A;  4LR9 A;  5DLV A;  1KHJ A;  1KH4 A;  2GLQ A;  3M8Y A;  3NKR A;  4YR1 A;  4GTY A;  1KH9 A;  1AJD A;  1ELX A;  4ZG9 A;  1ZEB A;  2RH6 A;  1EW8 A;  1SHQ A;  5IJQ A;  4CYR A;  3KD8 A;  1URA A;  1SHN A;  1EJJ A;  3SZZ A;  1HQA A;  3NKQ A;  1HDH A;  2W8S A;  1ELZ A;  5GRR A;  1ANJ A;  1FSU A;  1B8J A;  1URB A;  3OT9 A;  1EW2 A;  4FDJ A;  4LRD A;  4UPK A;  3DPC A;  2GSU A;  3BDH A;  4CXU A;  3TWZ A;  2G9Y A;  4LRF A;  3NVL A;  2XRG A;  4KM4 A;  1Y6V A;  1K7H A;  2W5S A;  4GTW A;  1E33 P;  1ZEF A;  3CMR A;  4LRA A;  5LIA A;  1E1Z P;  5L0K A;  5LRN A;  1EQJ A;  2QZU A;  3UN2 A;  4B56 A;  3M8W A;  1EI6 A;  4LR7 A;  4ZGA A;  3IGY B;  2GSN A;  2XR9 A;  3T01 A;  3WAV A;  3WBH A;  4MY4 A;  1AJA A;  1AJB A;  3DYC A;  1HJK A;  4GTZ A;  5EGH A;  5DLW A;  1ALJ A;  2GA3 A;  5K4P A;  3UO0 A;  3MK1 A;  1N2L A;  4KJG A;  5GOV A;  2X98 A;  1KHK A;  4KAY A;  3Q3Q A;  2W5R A;  3IGZ B;  4UOO A;  3M7V A;  4QAX A;  3T02 A;  1AJC A;  1O98 A;  3WAW A;  5KXA A;  3IDD A;  3UN5 A;  3BDG A;  4LQY A;  3NKO A;  4GTX A;  5INH A;  1KHL A;  4KAV A;  5LRM A;  2VQR A;  1Y7A A;  4NWJ A;  1ALK A;  2W5X A;  4CYS A;  3B5Q A;  4LRC A;  5L0E A;  1KHN A;  4LRE A;  4FDI A;  5IJS A;  3TG0 A;  4MHX A;  1E2S P;  4LR2 A;  4LRB A;  5DLT A;  1KH7 A;  1EW9 A;  1N2K A;  3NKN A;  5C66 A;  5L0B A;  4LR8 A;  2W5T A;  4UOR A;  3A52 A;  2W5Q A;  5AJ9 A;  1E3C P;  2GSO A;  3MK0 A;  4N7T A;  3UN3 A;  3WAX A;  3TX0 A;  1ZED A;  3WAY A;  1ALI A;  1KH5 A;  1ELY A;  4KJD A;  5EGE A;  4NWX A;  2ANH A;  2ZKT A;  1AUK A;  3UNY A;  4ZG7 A;  1ED8 A;  4UPL A;  2IFY A;  4MIV A;  3LXQ A;  3M8Z A;  5HRT A;  4CXK A;  3ED4 A;  4TN0 A;  3E2D A;  4UPI A;  1O99 A;  5TJ3 A;  1ALH A;  3SZY A;  3MK2 A;  1P49 A; 
#chains in the Genus database with same CATH topology
 1ANI A;  2IUC A;  2W5V A;  3BDF A;  4UOP A;  3NKM A;  3NKP A;  1ED9 A;  3T00 A;  4UPH A;  2IUC B;  2W8D A;  5LQQ A;  2D1G A;  4ZG6 A;  4CXS A;  3BDG B;  2W5W A;  4LR9 A;  5DLV A;  1KHJ A;  1KH4 A;  2GLQ A;  3M8Y A;  3NKR A;  4YR1 A;  4GTY A;  1KH9 A;  1AJD A;  1ELX A;  4ZG9 A;  1ZEB A;  2RH6 A;  1EW8 A;  1SHQ A;  5IJQ A;  4CYR A;  3KD8 A;  1URA A;  1SHN A;  1EJJ A;  3SZZ A;  1HQA A;  3NKQ A;  1HDH A;  2W8S A;  1ELZ A;  5GRR A;  1ANJ A;  1FSU A;  1B8J A;  1URB A;  3OT9 A;  1EW2 A;  4FDJ A;  4LRD A;  4UPK A;  3DPC A;  2GSU A;  3BDH A;  4CXU A;  3TWZ A;  2G9Y A;  4LRF A;  3NVL A;  2XRG A;  4KM4 A;  1Y6V A;  1K7H A;  2W5S A;  4GTW A;  1E33 P;  1ZEF A;  3CMR A;  4LRA A;  5LIA A;  1E1Z P;  5L0K A;  5LRN A;  1EQJ A;  2QZU A;  3UN2 A;  4B56 A;  3M8W A;  1EI6 A;  4LR7 A;  4ZGA A;  3IGY B;  2GSN A;  2XR9 A;  3T01 A;  3WAV A;  3WBH A;  4MY4 A;  1AJA A;  1AJB A;  3DYC A;  1HJK A;  4GTZ A;  5EGH A;  5DLW A;  1ALJ A;  2GA3 A;  5K4P A;  3UO0 A;  3MK1 A;  1N2L A;  4KJG A;  5GOV A;  2X98 A;  1KHK A;  4KAY A;  3Q3Q A;  2W5R A;  3IGZ B;  4UOO A;  3M7V A;  4QAX A;  3T02 A;  1AJC A;  1O98 A;  3WAW A;  5KXA A;  3IDD A;  3UN5 A;  3BDG A;  4LQY A;  3NKO A;  4GTX A;  5INH A;  1KHL A;  4KAV A;  5LRM A;  2VQR A;  1Y7A A;  4NWJ A;  1ALK A;  2W5X A;  4CYS A;  3B5Q A;  4LRC A;  5L0E A;  1KHN A;  4LRE A;  4FDI A;  5IJS A;  3TG0 A;  4MHX A;  1E2S P;  4LR2 A;  4LRB A;  5DLT A;  1KH7 A;  1EW9 A;  1N2K A;  3NKN A;  5C66 A;  5L0B A;  4LR8 A;  2W5T A;  4UOR A;  3A52 A;  2W5Q A;  5AJ9 A;  1E3C P;  2GSO A;  3MK0 A;  4N7T A;  3UN3 A;  3WAX A;  3TX0 A;  1ZED A;  3WAY A;  1ALI A;  1KH5 A;  1ELY A;  4KJD A;  5EGE A;  4NWX A;  2ANH A;  2ZKT A;  1AUK A;  3UNY A;  4ZG7 A;  1ED8 A;  4UPL A;  2IFY A;  4MIV A;  3LXQ A;  3M8Z A;  5HRT A;  4CXK A;  3ED4 A;  4TN0 A;  3E2D A;  4UPI A;  1O99 A;  5TJ3 A;  1ALH A;  3SZY A;  3MK2 A;  1P49 A; 
#chains in the Genus database with same CATH homology
 1ANI A;  2IUC A;  2W5V A;  3BDF A;  4UOP A;  3NKM A;  3NKP A;  1ED9 A;  3T00 A;  4UPH A;  2IUC B;  2W8D A;  5LQQ A;  2D1G A;  4ZG6 A;  4CXS A;  3BDG B;  2W5W A;  4LR9 A;  5DLV A;  1KHJ A;  1KH4 A;  2GLQ A;  3M8Y A;  3NKR A;  4YR1 A;  4GTY A;  1KH9 A;  1AJD A;  1ELX A;  4ZG9 A;  1ZEB A;  2RH6 A;  1EW8 A;  1SHQ A;  5IJQ A;  4CYR A;  3KD8 A;  1URA A;  1SHN A;  1EJJ A;  3SZZ A;  1HQA A;  3NKQ A;  1HDH A;  2W8S A;  1ELZ A;  5GRR A;  1ANJ A;  1FSU A;  1B8J A;  1URB A;  3OT9 A;  1EW2 A;  4FDJ A;  4LRD A;  4UPK A;  3DPC A;  2GSU A;  3BDH A;  4CXU A;  3TWZ A;  2G9Y A;  4LRF A;  3NVL A;  2XRG A;  4KM4 A;  1Y6V A;  1K7H A;  2W5S A;  4GTW A;  1E33 P;  1ZEF A;  3CMR A;  4LRA A;  5LIA A;  1E1Z P;  5L0K A;  5LRN A;  1EQJ A;  2QZU A;  3UN2 A;  4B56 A;  3M8W A;  1EI6 A;  4LR7 A;  4ZGA A;  3IGY B;  2GSN A;  2XR9 A;  3T01 A;  3WAV A;  3WBH A;  4MY4 A;  1AJA A;  1AJB A;  3DYC A;  1HJK A;  4GTZ A;  5EGH A;  5DLW A;  1ALJ A;  2GA3 A;  5K4P A;  3UO0 A;  3MK1 A;  1N2L A;  4KJG A;  5GOV A;  2X98 A;  1KHK A;  4KAY A;  3Q3Q A;  2W5R A;  3IGZ B;  4UOO A;  3M7V A;  4QAX A;  3T02 A;  1AJC A;  1O98 A;  3WAW A;  5KXA A;  3IDD A;  3UN5 A;  3BDG A;  4LQY A;  3NKO A;  4GTX A;  5INH A;  1KHL A;  4KAV A;  5LRM A;  2VQR A;  1Y7A A;  4NWJ A;  1ALK A;  2W5X A;  4CYS A;  3B5Q A;  4LRC A;  5L0E A;  1KHN A;  4LRE A;  4FDI A;  5IJS A;  3TG0 A;  4MHX A;  1E2S P;  4LR2 A;  4LRB A;  5DLT A;  1KH7 A;  1EW9 A;  1N2K A;  3NKN A;  5C66 A;  5L0B A;  4LR8 A;  2W5T A;  4UOR A;  3A52 A;  2W5Q A;  5AJ9 A;  1E3C P;  2GSO A;  3MK0 A;  4N7T A;  3UN3 A;  3WAX A;  3TX0 A;  1ZED A;  3WAY A;  1ALI A;  1KH5 A;  1ELY A;  4KJD A;  5EGE A;  4NWX A;  2ANH A;  2ZKT A;  1AUK A;  3UNY A;  4ZG7 A;  1ED8 A;  4UPL A;  2IFY A;  4MIV A;  3LXQ A;  3M8Z A;  5HRT A;  4CXK A;  3ED4 A;  4TN0 A;  3E2D A;  4UPI A;  1O99 A;  5TJ3 A;  1ALH A;  3SZY A;  3MK2 A;  1P49 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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