1EW2A

Crystal structure of a human phosphatase
Total Genus 172
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
172
Knots found
sequence length
479
structure length
479
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords PHOSPHATASE
publication title Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.
pubmed doi rcsb
total genus 172
structure length 479
sequence length 479
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew2A00
1B8JA 3WAVA 2G9YA 1EW9A 1ED9A 5TJ3A 3TWZA 2VQRA 2GSUA 3Q3QA 3B5QA 1FSUA 1AUKA 4CYSA 1E2SP 3BDGA 3WAXA 5LRNA 1AJAA 4GTWA 3UNYA 1E33P 5EGHA 1KHNA 3DPCA 1P49A 1ZEBA 3NKRA 1K7HA 5K4PA 1KH4A 4UOOA 3OT9A 5DLWA 5GOVA 4ZGAA 3A52A 1EJJA 1EI6A 3BDFA 3NKMA 1E3CP 2W5WA 5L0KA 5L0BA 1KHKA 1HQAA 3IGZB 3UN3A 3MK2A 1ALHA 3ED4A 3SZYA 4LRCA 1ALIA 5INHA 3T02A 4LR9A 1N2KA 4UPKA 2IUCB 4LRDA 1AJDA 3IGYB 4UOPA 3NKQA 3M8YA 3M8WA 3MK0A 3SZZA 1Y7AA 1SHNA 2RH6A 4UPLA 5LQQA 1HJKA 1URAA 3T00A 2GSOA 1KH7A 4UORA 2W5XA 1ALKA 3BDHA 2ZKTA 4FDJA 4CXSA 3BDGB 1O99A 1KH5A 4KAVA 5DLTA 4CXUA 2W5TA 3WBHA 4KM4A 4ZG9A 2W5RA 5C66A 2XRGA 1ELYA 5IJQA 4MIVA 2W5SA 5EGEA 4ZG7A 3CMRA 5KXAA 4UPIA 4TN0A 4CXKA 1ANJA 2XR9A 3NKPA 4LR2A 3KD8A 1HDHA 4KJGA 4CYRA 1KH9A 3M8ZA 1ANIA 3TX0A 4NWXA 1ELZA 4N7TA 4UPHA 4ZG6A 5DLVA 2D1GA 3DYCA 3MK1A 3WAWA 1EW8A 1URBA 1Y6VA 4QAXA 1KHJA 2X98A 4B56A 1ED8A 3TG0A 1ZEFA 1EQJA 4LREA 1SHQA 4YR1A 2ANHA 1KHLA 1N2LA 5HRTA 1AJBA 1ZEDA 2GLQA 4GTYA 4LRAA 4LQYA 2W5QA 4LRFA 3WAYA 3NVLA 3LXQA 3UO0A 4GTXA 4LRBA 5L0EA 3NKNA 5IJSA 3UN5A 3E2DA 3NKOA 4KAYA 4GTZA 1O98A 1EW2A 2QZUA 2W8DA 4LR7A 2W8SA 3M7VA 5LRMA 5LIAA 4MHXA 4NWJA 4FDIA 1E1ZP 4KJDA 2IFYA 2IUCA 2W5VA 1ALJA 2GA3A 3T01A 4MY4A 4LR8A 5GRRA 2GSNA 3IDDA 1ELXA 5AJ9A 1AJCA 3UN2A
chains in the Genus database with same CATH superfamily
1B8JA 3WAVA 2G9YA 1EW9A 1ED9A 5TJ3A 3TWZA 2VQRA 2GSUA 3Q3QA 3B5QA 1FSUA 1AUKA 4CYSA 1E2SP 3BDGA 3WAXA 5LRNA 1AJAA 4GTWA 3UNYA 1E33P 5EGHA 1KHNA 3DPCA 1P49A 1ZEBA 3NKRA 1K7HA 5K4PA 1KH4A 4UOOA 3OT9A 5DLWA 5GOVA 4ZGAA 3A52A 1EJJA 1EI6A 3BDFA 3NKMA 1E3CP 2W5WA 5L0KA 5L0BA 1KHKA 1HQAA 3IGZB 3UN3A 3MK2A 1ALHA 3ED4A 3SZYA 4LRCA 1ALIA 5INHA 3T02A 4LR9A 1N2KA 4UPKA 2IUCB 4LRDA 1AJDA 3IGYB 4UOPA 3NKQA 3M8YA 3M8WA 3MK0A 3SZZA 1Y7AA 1SHNA 2RH6A 4UPLA 5LQQA 1HJKA 1URAA 3T00A 2GSOA 1KH7A 4UORA 2W5XA 1ALKA 3BDHA 2ZKTA 4FDJA 4CXSA 3BDGB 1O99A 1KH5A 4KAVA 5DLTA 4CXUA 2W5TA 3WBHA 4KM4A 4ZG9A 2W5RA 5C66A 2XRGA 1ELYA 5IJQA 4MIVA 2W5SA 5EGEA 4ZG7A 3CMRA 5KXAA 4UPIA 4TN0A 4CXKA 1ANJA 2XR9A 3NKPA 4LR2A 3KD8A 1HDHA 4KJGA 4CYRA 1KH9A 3M8ZA 1ANIA 3TX0A 4NWXA 1ELZA 4N7TA 4UPHA 4ZG6A 5DLVA 2D1GA 3DYCA 3MK1A 3WAWA 1EW8A 1URBA 1Y6VA 4QAXA 1KHJA 2X98A 4B56A 1ED8A 3TG0A 1ZEFA 1EQJA 4LREA 1SHQA 4YR1A 2ANHA 1KHLA 1N2LA 5HRTA 1AJBA 1ZEDA 2GLQA 4GTYA 4LRAA 4LQYA 2W5QA 4LRFA 3WAYA 3NVLA 3LXQA 3UO0A 4GTXA 4LRBA 5L0EA 3NKNA 5IJSA 3UN5A 3E2DA 3NKOA 4KAYA 4GTZA 1O98A 1EW2A 2QZUA 2W8DA 4LR7A 2W8SA 3M7VA 5LRMA 5LIAA 4MHXA 4NWJA 4FDIA 1E1ZP 4KJDA 2IFYA 2IUCA 2W5VA 1ALJA 2GA3A 3T01A 4MY4A 4LR8A 5GRRA 2GSNA 3IDDA 1ELXA 5AJ9A 1AJCA 3UN2A
chains in the Genus database with same CATH topology
1B8JA 3WAVA 2G9YA 1EW9A 1ED9A 5TJ3A 3TWZA 2VQRA 2GSUA 3Q3QA 3B5QA 1FSUA 1AUKA 4CYSA 1E2SP 3BDGA 3WAXA 5LRNA 1AJAA 4GTWA 3UNYA 1E33P 5EGHA 1KHNA 3DPCA 1P49A 1ZEBA 3NKRA 1K7HA 5K4PA 1KH4A 4UOOA 3OT9A 5DLWA 5GOVA 4ZGAA 3A52A 1EJJA 1EI6A 3BDFA 3NKMA 1E3CP 2W5WA 5L0KA 5L0BA 1KHKA 1HQAA 3IGZB 3UN3A 3MK2A 1ALHA 3ED4A 3SZYA 4LRCA 1ALIA 5INHA 3T02A 4LR9A 1N2KA 4UPKA 2IUCB 4LRDA 1AJDA 3IGYB 4UOPA 3NKQA 3M8YA 3M8WA 3MK0A 3SZZA 1Y7AA 1SHNA 2RH6A 4UPLA 5LQQA 1HJKA 1URAA 3T00A 2GSOA 1KH7A 4UORA 2W5XA 1ALKA 3BDHA 2ZKTA 4FDJA 4CXSA 3BDGB 1O99A 1KH5A 4KAVA 5DLTA 4CXUA 2W5TA 3WBHA 4KM4A 4ZG9A 2W5RA 5C66A 2XRGA 1ELYA 5IJQA 4MIVA 2W5SA 5EGEA 4ZG7A 3CMRA 5KXAA 4UPIA 4TN0A 4CXKA 1ANJA 2XR9A 3NKPA 4LR2A 3KD8A 1HDHA 4KJGA 4CYRA 1KH9A 3M8ZA 1ANIA 3TX0A 4NWXA 1ELZA 4N7TA 4UPHA 4ZG6A 5DLVA 2D1GA 3DYCA 3MK1A 3WAWA 1EW8A 1URBA 1Y6VA 4QAXA 1KHJA 2X98A 4B56A 1ED8A 3TG0A 1ZEFA 1EQJA 4LREA 1SHQA 4YR1A 2ANHA 1KHLA 1N2LA 5HRTA 1AJBA 1ZEDA 2GLQA 4GTYA 4LRAA 4LQYA 2W5QA 4LRFA 3WAYA 3NVLA 3LXQA 3UO0A 4GTXA 4LRBA 5L0EA 3NKNA 5IJSA 3UN5A 3E2DA 3NKOA 4KAYA 4GTZA 1O98A 1EW2A 2QZUA 2W8DA 4LR7A 2W8SA 3M7VA 5LRMA 5LIAA 4MHXA 4NWJA 4FDIA 1E1ZP 4KJDA 2IFYA 2IUCA 2W5VA 1ALJA 2GA3A 3T01A 4MY4A 4LR8A 5GRRA 2GSNA 3IDDA 1ELXA 5AJ9A 1AJCA 3UN2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1B8J A;  3WAV A;  2G9Y A;  1EW9 A;  1ED9 A;  5TJ3 A;  3TWZ A;  2VQR A;  2GSU A;  3Q3Q A;  3B5Q A;  1FSU A;  1AUK A;  4CYS A;  1E2S P;  3BDG A;  3WAX A;  5LRN A;  1AJA A;  4GTW A;  3UNY A;  1E33 P;  5EGH A;  1KHN A;  3DPC A;  1P49 A;  1ZEB A;  3NKR A;  1K7H A;  5K4P A;  1KH4 A;  4UOO A;  3OT9 A;  5DLW A;  5GOV A;  4ZGA A;  3A52 A;  1EJJ A;  1EI6 A;  3BDF A;  3NKM A;  1E3C P;  2W5W A;  5L0K A;  5L0B A;  1KHK A;  1HQA A;  3IGZ B;  3UN3 A;  3MK2 A;  1ALH A;  3ED4 A;  3SZY A;  4LRC A;  1ALI A;  5INH A;  3T02 A;  4LR9 A;  1N2K A;  4UPK A;  2IUC B;  4LRD A;  1AJD A;  3IGY B;  4UOP A;  3NKQ A;  3M8Y A;  3M8W A;  3MK0 A;  3SZZ A;  1Y7A A;  1SHN A;  2RH6 A;  4UPL A;  5LQQ A;  1HJK A;  1URA A;  3T00 A;  2GSO A;  1KH7 A;  4UOR A;  2W5X A;  1ALK A;  3BDH A;  2ZKT A;  4FDJ A;  4CXS A;  3BDG B;  1O99 A;  1KH5 A;  4KAV A;  5DLT A;  4CXU A;  2W5T A;  3WBH A;  4KM4 A;  4ZG9 A;  2W5R A;  5C66 A;  2XRG A;  1ELY A;  5IJQ A;  4MIV A;  2W5S A;  5EGE A;  4ZG7 A;  3CMR A;  5KXA A;  4UPI A;  4TN0 A;  4CXK A;  1ANJ A;  2XR9 A;  3NKP A;  4LR2 A;  3KD8 A;  1HDH A;  4KJG A;  4CYR A;  1KH9 A;  3M8Z A;  1ANI A;  3TX0 A;  4NWX A;  1ELZ A;  4N7T A;  4UPH A;  4ZG6 A;  5DLV A;  2D1G A;  3DYC A;  3MK1 A;  3WAW A;  1EW8 A;  1URB A;  1Y6V A;  4QAX A;  1KHJ A;  2X98 A;  4B56 A;  1ED8 A;  3TG0 A;  1ZEF A;  1EQJ A;  4LRE A;  1SHQ A;  4YR1 A;  2ANH A;  1KHL A;  1N2L A;  5HRT A;  1AJB A;  1ZED A;  2GLQ A;  4GTY A;  4LRA A;  4LQY A;  2W5Q A;  4LRF A;  3WAY A;  3NVL A;  3LXQ A;  3UO0 A;  4GTX A;  4LRB A;  5L0E A;  3NKN A;  5IJS A;  3UN5 A;  3E2D A;  3NKO A;  4KAY A;  4GTZ A;  1O98 A;  1EW2 A;  2QZU A;  2W8D A;  4LR7 A;  2W8S A;  3M7V A;  5LRM A;  5LIA A;  4MHX A;  4NWJ A;  4FDI A;  1E1Z P;  4KJD A;  2IFY A;  2IUC A;  2W5V A;  1ALJ A;  2GA3 A;  3T01 A;  4MY4 A;  4LR8 A;  5GRR A;  2GSN A;  3IDD A;  1ELX A;  5AJ9 A;  1AJC A;  3UN2 A; 
#chains in the Genus database with same CATH topology
 1B8J A;  3WAV A;  2G9Y A;  1EW9 A;  1ED9 A;  5TJ3 A;  3TWZ A;  2VQR A;  2GSU A;  3Q3Q A;  3B5Q A;  1FSU A;  1AUK A;  4CYS A;  1E2S P;  3BDG A;  3WAX A;  5LRN A;  1AJA A;  4GTW A;  3UNY A;  1E33 P;  5EGH A;  1KHN A;  3DPC A;  1P49 A;  1ZEB A;  3NKR A;  1K7H A;  5K4P A;  1KH4 A;  4UOO A;  3OT9 A;  5DLW A;  5GOV A;  4ZGA A;  3A52 A;  1EJJ A;  1EI6 A;  3BDF A;  3NKM A;  1E3C P;  2W5W A;  5L0K A;  5L0B A;  1KHK A;  1HQA A;  3IGZ B;  3UN3 A;  3MK2 A;  1ALH A;  3ED4 A;  3SZY A;  4LRC A;  1ALI A;  5INH A;  3T02 A;  4LR9 A;  1N2K A;  4UPK A;  2IUC B;  4LRD A;  1AJD A;  3IGY B;  4UOP A;  3NKQ A;  3M8Y A;  3M8W A;  3MK0 A;  3SZZ A;  1Y7A A;  1SHN A;  2RH6 A;  4UPL A;  5LQQ A;  1HJK A;  1URA A;  3T00 A;  2GSO A;  1KH7 A;  4UOR A;  2W5X A;  1ALK A;  3BDH A;  2ZKT A;  4FDJ A;  4CXS A;  3BDG B;  1O99 A;  1KH5 A;  4KAV A;  5DLT A;  4CXU A;  2W5T A;  3WBH A;  4KM4 A;  4ZG9 A;  2W5R A;  5C66 A;  2XRG A;  1ELY A;  5IJQ A;  4MIV A;  2W5S A;  5EGE A;  4ZG7 A;  3CMR A;  5KXA A;  4UPI A;  4TN0 A;  4CXK A;  1ANJ A;  2XR9 A;  3NKP A;  4LR2 A;  3KD8 A;  1HDH A;  4KJG A;  4CYR A;  1KH9 A;  3M8Z A;  1ANI A;  3TX0 A;  4NWX A;  1ELZ A;  4N7T A;  4UPH A;  4ZG6 A;  5DLV A;  2D1G A;  3DYC A;  3MK1 A;  3WAW A;  1EW8 A;  1URB A;  1Y6V A;  4QAX A;  1KHJ A;  2X98 A;  4B56 A;  1ED8 A;  3TG0 A;  1ZEF A;  1EQJ A;  4LRE A;  1SHQ A;  4YR1 A;  2ANH A;  1KHL A;  1N2L A;  5HRT A;  1AJB A;  1ZED A;  2GLQ A;  4GTY A;  4LRA A;  4LQY A;  2W5Q A;  4LRF A;  3WAY A;  3NVL A;  3LXQ A;  3UO0 A;  4GTX A;  4LRB A;  5L0E A;  3NKN A;  5IJS A;  3UN5 A;  3E2D A;  3NKO A;  4KAY A;  4GTZ A;  1O98 A;  1EW2 A;  2QZU A;  2W8D A;  4LR7 A;  2W8S A;  3M7V A;  5LRM A;  5LIA A;  4MHX A;  4NWJ A;  4FDI A;  1E1Z P;  4KJD A;  2IFY A;  2IUC A;  2W5V A;  1ALJ A;  2GA3 A;  3T01 A;  4MY4 A;  4LR8 A;  5GRR A;  2GSN A;  3IDD A;  1ELX A;  5AJ9 A;  1AJC A;  3UN2 A; 
#chains in the Genus database with same CATH homology
 1B8J A;  3WAV A;  2G9Y A;  1EW9 A;  1ED9 A;  5TJ3 A;  3TWZ A;  2VQR A;  2GSU A;  3Q3Q A;  3B5Q A;  1FSU A;  1AUK A;  4CYS A;  1E2S P;  3BDG A;  3WAX A;  5LRN A;  1AJA A;  4GTW A;  3UNY A;  1E33 P;  5EGH A;  1KHN A;  3DPC A;  1P49 A;  1ZEB A;  3NKR A;  1K7H A;  5K4P A;  1KH4 A;  4UOO A;  3OT9 A;  5DLW A;  5GOV A;  4ZGA A;  3A52 A;  1EJJ A;  1EI6 A;  3BDF A;  3NKM A;  1E3C P;  2W5W A;  5L0K A;  5L0B A;  1KHK A;  1HQA A;  3IGZ B;  3UN3 A;  3MK2 A;  1ALH A;  3ED4 A;  3SZY A;  4LRC A;  1ALI A;  5INH A;  3T02 A;  4LR9 A;  1N2K A;  4UPK A;  2IUC B;  4LRD A;  1AJD A;  3IGY B;  4UOP A;  3NKQ A;  3M8Y A;  3M8W A;  3MK0 A;  3SZZ A;  1Y7A A;  1SHN A;  2RH6 A;  4UPL A;  5LQQ A;  1HJK A;  1URA A;  3T00 A;  2GSO A;  1KH7 A;  4UOR A;  2W5X A;  1ALK A;  3BDH A;  2ZKT A;  4FDJ A;  4CXS A;  3BDG B;  1O99 A;  1KH5 A;  4KAV A;  5DLT A;  4CXU A;  2W5T A;  3WBH A;  4KM4 A;  4ZG9 A;  2W5R A;  5C66 A;  2XRG A;  1ELY A;  5IJQ A;  4MIV A;  2W5S A;  5EGE A;  4ZG7 A;  3CMR A;  5KXA A;  4UPI A;  4TN0 A;  4CXK A;  1ANJ A;  2XR9 A;  3NKP A;  4LR2 A;  3KD8 A;  1HDH A;  4KJG A;  4CYR A;  1KH9 A;  3M8Z A;  1ANI A;  3TX0 A;  4NWX A;  1ELZ A;  4N7T A;  4UPH A;  4ZG6 A;  5DLV A;  2D1G A;  3DYC A;  3MK1 A;  3WAW A;  1EW8 A;  1URB A;  1Y6V A;  4QAX A;  1KHJ A;  2X98 A;  4B56 A;  1ED8 A;  3TG0 A;  1ZEF A;  1EQJ A;  4LRE A;  1SHQ A;  4YR1 A;  2ANH A;  1KHL A;  1N2L A;  5HRT A;  1AJB A;  1ZED A;  2GLQ A;  4GTY A;  4LRA A;  4LQY A;  2W5Q A;  4LRF A;  3WAY A;  3NVL A;  3LXQ A;  3UO0 A;  4GTX A;  4LRB A;  5L0E A;  3NKN A;  5IJS A;  3UN5 A;  3E2D A;  3NKO A;  4KAY A;  4GTZ A;  1O98 A;  1EW2 A;  2QZU A;  2W8D A;  4LR7 A;  2W8S A;  3M7V A;  5LRM A;  5LIA A;  4MHX A;  4NWJ A;  4FDI A;  1E1Z P;  4KJD A;  2IFY A;  2IUC A;  2W5V A;  1ALJ A;  2GA3 A;  3T01 A;  4MY4 A;  4LR8 A;  5GRR A;  2GSN A;  3IDD A;  1ELX A;  5AJ9 A;  1AJC A;  3UN2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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