The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
235
|
sequence length |
619
|
structure length |
619
|
Chain Sequence |
AYARTLDRAVEYLLSCQKDEGYWWGPLLSNVTMEAEYVLLCHILDRVDRDRMEKIRRYLLHEQREDGTWALYPGGPPDLDTTIEAYVALKYIGMSRDEEPMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWEKVPMVPPEIMFLGKRMPLNIYEFGSWARATVVALSIVMSRQPVFPLPERARVPELYETDVPPRRRGAKGGGGWIFDALDRALHGYQKLSVHPFRRAAEIRALDWLLERQAGDGSWGGIQPPWFYALIALKILDMTQHPAFIKGWEGLELYGVELDYGGWMFQASISPVWDTGLAVLALRAAGLPADHDRLVKAGEWLLDRQITVPGDWAVKRPNLKPGGFAFQFDNVYYPDVDDTAVVVWALNTLRLPDERRRRDAMTKGFRWIVGMQSSNGGWGAYDVDNTSDLPNHIPFCDFGEVTDPPSEDVTAHVLECFGSFGYDDAWKVIRRAVEYLKREQKPDGSWFGRWGVNYLYGTGAVVSALKAVGIDTREPYIQKALDWVEQHQNPDGGWGEDCRSYEDPAYAGKGASTPSQTAWALMALIAGGRAESEAARRGVQYLVETQRPDGGWDEPYYTGTGFPGDFYLGYTMYRHVFPTLALGRYKQAI
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
pubmed doi rcsb |
| molecule tags |
Isomerase
|
| source organism |
Alicyclobacillus acidocaldarius
|
| molecule keywords |
SQUALENE--HOPENE CYCLASE
|
| total genus |
235
|
| structure length |
619
|
| sequence length |
619
|
| chains with identical sequence |
B, C
|
| ec nomenclature |
ec
4.2.1.129: Squalene--hopanol cyclase. |
| pdb deposition date | 2002-08-25 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00432 | Prenyltrans | Prenyltransferase and squalene oxidase repeat |
| A | PF13243 | SQHop_cyclase_C | Squalene-hopene cyclase C-terminal domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Alpha/alpha barrel | Glycosyltransferase | Glycosyltransferase | ||
| Mainly Alpha | Alpha/alpha barrel | Glycosyltransferase | Glycosyltransferase |
#chains in the Genus database with same CATH superfamily 2BED B; 3HXF B; 3PZ3 B; 4GTT B; 4C1S A; 4D4A A; 2NOJ A; 2V8K A; 2B39 A; 4GTR B; 4GTP B; 3OED A; 1O6Q A; 4M76 A; 3HXD B; 4BOJ A; 4V1S A; 1GXN A; 2PN5 A; 1C3D A; 2I07 B; 3HXB B; 3E33 B; 4FXG B; 4MU9 A; 1W6K A; 3RJ3 A; 2WY7 A; 5FO7 B; 1N4Q B; 1O6H A; 2H6G B; 2PMV A; 3D5R A; 4BOK A; 1TN7 B; 1KZO B; 1X81 B; 2G02 A; 1MZC B; 5FO8 B; 3PZ2 B; 3KQ4 A; 4ZRQ A; 1O1R B; 1TN8 B; 1HZF A; 2H6H B; 1FPP B; 3DSS B; 3DST B; 1H36 A; 3HXE B; 1H39 A; 5AGD A; 1O79 A; 4YDO B; 2V8J A; 1N4P B; 1TNY B; 4FXK B; 2XWJ B; 1O1S B; 1SQC A; 4D94 A; 2V8I A; 2V3P A; 2F0Y B; 1H37 A; 4L9P B; 1N94 B; 3EU5 B; 4MBG B; 4LNB B; 4GTV B; 3KSQ B; 1H3A A; 1JCS B; 3E30 B; 3C72 B; 1QBQ B; 3Q78 B; 3HXC B; 2BB5 A; 4D4B A; 3OXU A; 4D4C A; 4LNV A; 3KLS A; 1GSZ A; 1SA4 B; 2H6I B; 3E34 B; 3K7X A; 1O5M B; 1JCR B; 1O1T B; 1D8D B; 2A73 B; 3DSX B; 5FO9 B; 3PZ4 B; 4GTO B; 4ZRP A; 2BB6 A; 3G6J B; 1H35 A; 2G0D A; 1UMP A; 1TNZ B; 2ZIR B; 3DSV B; 3EUV B; 1N95 B; 1TNB B; 1H3B A; 1LTX B; 2V3N A; 1KZP B; 1GXM A; 3Q73 B; 1NL4 B; 2BBC A; 3SFY B; 5JPN B; 2XWB B; 2XQW A; 1N9A B; 2GOX A; 3DPY B; 4GTS B; 4KKJ A; 1TNO B; 3Q75 B; 1O6R A; 1GHQ A; 2R2L B; 1TNU B; 3PZ1 B; 2H6F B; 4D4D A; 1N4S B; 1QSJ A; 1S63 B; 3SQC A; 4ONT A; 3Q7A B; 1FT1 B; 5JPM B; 1LD7 B; 2WIN B; 1LD8 B; 3E32 B; 2WII B; 3E37 B; 4GTM B; 3CU7 A; 4GTQ B; 4EHM B; 3SFX B; 4ZH1 A; 2SQC A; 4V1R A; 2IEJ B; 1FT2 B; 1JCQ B; 1R76 A; 1NI1 B; 3KSL B; 4LNG B; 1TN6 B; 1S64 B; 3D5S A; 3Q79 B; 1DCE B; 3DSW B; 1H3C A; 1QQF A; 1N4R B; 2WY8 A; 3DRA B; 4YDE B; 1GXO A; 2ZIS B; 5FOB B; 1W6J A; 1SA5 B; 3DSU B; 4KKI A; 1D8E B; 3Q7F B; #chains in the Genus database with same CATH topology 5IK9 A; 1G9J A; 4J5T A; 3N0F A; 4C1S A; 3SDT A; 2NOJ A; 2B39 A; 4Q2B A; 1O6Q A; 1GLM A; 1V7W A; 4AYP A; 3S4C A; 4M76 A; 1GXN A; 1C3D A; 4FXG B; 4OK4 A; 4DI5 A; 3M76 A; 3VXD A; 1W6K A; 1F9G A; 2WY7 A; 5FO7 B; 5M7I A; 5ILI A; 4GAX A; 1UT9 A; 1FBW A; 1KZO B; 1X81 B; 5M7Y A; 4MMH A; 1X9D A; 1HZF A; 1TN8 B; 2H6H B; 3VSN A; 3DSS B; 3P5R A; 1V5C A; 4CE7 A; 5ILK A; 4DOD A; 5AGD A; 3M77 A; 3NNB A; 1N4P B; 4FXK B; 2ONG A; 4L9P B; 5IM1 A; 4GTV B; 1HXG A; 2JG0 A; 4XUV A; 2RGK A; 2BB5 A; 4KTP A; 1WU6 A; 3KLS A; 1GSZ A; 1LF9 A; 4OK2 A; 3K7X A; 1G9G A; 1OJO A; 2A73 B; 2FUT A; 5DGR A; 4Z4L A; 1X1H A; 1I8Q A; 3E73 A; 3WKI A; 2G0D A; 1UMP A; 1TNZ B; 1RQ5 A; 3EUV B; 3M02 A; 3G4D A; 1N95 B; 3VSM A; 1CLC A; 2JF4 A; 3H3K A; 1GXM A; 2NVP A; 1FP3 A; 2DRQ A; 3M7C A; 5IKH A; 4JJJ A; 4GTS B; 1FCE A; 4KKJ A; 2AFA A; 1IA6 A; 5DGQ A; 1GHQ A; 2H6F B; 5GW7 A; 1N4S B; 1S63 B; 3QWT A; 3ANJ A; 3SQC A; 3Q7A B; 1FT1 B; 1N23 A; 3EU8 A; 3WC3 A; 4GTM B; 1OJP A; 2XFG A; 3TF4 A; 3H7L A; 3CU7 A; 4FUS A; 3T33 A; 1F9D A; 2SQC A; 2ZBL A; 2IEJ B; 1N21 A; 3PYB A; 3X17 A; 1KRF A; 3W5M A; 2FV0 A; 3AFL A; 1L1Y A; 3KSL B; 3WIW A; 1LF6 A; 1NC5 A; 2Z07 A; 3E80 A; 1TF4 A; 2B4F A; 1H3C A; 3W5N A; 1N4R B; 2WY8 A; 5FOB B; 3M01 A; 3G4F A; 2DRO A; 1GA2 A; 3RSY A; 1N7P A; 1N20 A; 4GTR B; 3OED A; 5ILY A; 3CIH A; 1N7Q A; 2BRW A; 2VN4 A; 3HXB B; 2I07 B; 1LXK A; 4OZW A; 5FO8 B; 1N7N A; 3M75 A; 2YIK A; 4ZRQ A; 1WU4 A; 1W3Y A; 3GT5 A; 1FO3 A; 4RNQ A; 1H39 A; 4E1Y A; 1N7O A; 4YDO B; 3W7S A; 2EAC A; 1TNY B; 3S4A A; 2XWJ B; 4WU0 A; 3ANI A; 1H3A A; 1JCS B; 3E30 B; 3C72 B; 3EZ8 A; 3P5P A; 3Q78 B; 3OXU A; 3A3V A; 4LNV A; 5CZL A; 1AGM A; 3M00 A; 3E34 B; 5E2J A; 1O5M B; 3WIR A; 2AHG A; 1RWG A; 1KRE A; 3DSX B; 3PZ4 B; 3QFY A; 4ZRP A; 2BB6 A; 1H35 A; 2ZIR B; 1H3B A; 1LTX B; 2V3N A; 3SDR A; 5ILH A; 2QNO A; 1DOG A; 4Z4J A; 3GZK A; 3RX8 A; 2OKX A; 5ILZ A; 1KKT A; 3D3I A; 1N22 A; 1N9A B; 3DPY B; 1NXC A; 1C82 A; 3M71 A; 3SDU A; 2ONH A; 3M7L A; 1F1S A; 4D4D A; 1QSJ A; 3ACS A; 5JPM B; 1LD7 B; 4GL3 A; 1IS9 A; 4GTQ B; 1HXA A; 4L0G A; 5EAU A; 4EHM B; 3NFV A; 4ZH1 A; 4F10 A; 4V1R A; 5DHI A; 1N1B A; 3SDV A; 1FT2 B; 1JCQ B; 1HMU A; 1HCU A; 1ULV A; 2FV1 A; 1AYX A; 1S64 B; 1RWH A; 4NEI A; 4EL8 A; 3W7W A; 3Q79 B; 3DSW B; 3QPF A; 5IL3 A; 3H2W A; 2EAE A; 1GXO A; 3DSU B; 4OZV A; 3Q7F B; 1HX9 A; 3HXF B; 4GTT B; 1X1J A; 2V8K A; 4D4A A; 2WDA A; 4L6X A; 3LZ9 A; 3ANK A; 3QXQ A; 3HXD B; 3W7U A; 5C05 A; 4MU9 A; 2EAB A; 1XW2 A; 1H54 A; 1OJN A; 1N4Q B; 5EAT A; 2H6G B; 3P2C A; 2PMV A; 3D5R A; 4BOK A; 1TN7 B; 1J0N A; 1MZC B; 1EGU A; 2E22 A; 3M7B A; 1O1R B; 1CB8 A; 1N7R A; 3M73 A; 1O79 A; 2BRP A; 1FBO A; 1KS8 A; 2V8J A; 2P0V A; 3QSP A; 1H14 A; 1SQC A; 4D94 A; 2V8I A; 2V3P A; 2F0Y B; 1H37 A; 1N94 B; 2A8Z A; 4LNB B; 2E24 A; 3WIQ A; 2CQT A; 3RX7 A; 3HXC B; 4D4C A; 4OJZ A; 2H6I B; 2J5C A; 2D8L A; 3M7E A; 1J0M A; 1LXM A; 2EAD A; 1FAE A; 1KFG A; 2WYN A; 3DSV B; 3SDQ A; 1TNB B; 1GAH A; 4WVC A; 5GY3 A; 4AYQ A; 1HM3 A; 1V5D A; 1KZP B; 2FUZ A; 3Q73 B; 1NL4 B; 3SFY B; 2AHF A; 4LIX A; 4QT9 A; 1L2A A; 2BRV X; 2GOX A; 5IK0 A; 5CA3 A; 3S4B A; 1FO2 A; 3Q75 B; 1O6R A; 1F9O A; 2R2L B; 3W7X A; 1HMW A; 2DRS A; 3M78 A; 4ONT A; 2JJB A; 3PMM A; 3RRS A; 1LD8 B; 3E32 B; 2WII B; 5IKA A; 1V7X A; 3WKF A; 4AYO A; 3SFX B; 3E6U A; 3PYA A; 1KWF A; 1R76 A; 3REN A; 5JMF A; 1NI1 B; 4LNG B; 1TN6 B; 3QRY A; 5IL8 A; 1H13 A; 1RWF A; 2X03 A; 4MMI A; 1DCE B; 2DRR A; 2GH4 A; 1RW9 A; 3ACT A; 4CJ0 A; 4YDE B; 3SAE A; 2WCO A; 1XWQ A; 1FMI A; 1D8E B; 4YCR A; 1WU5 A; 2BED B; 3PZ3 B; 2F6D A; 4GTP B; 1HV6 A; 1V7V A; 1LOH A; 4ZH5 A; 2CQS A; 5JMD A; 1RWA A; 3WUX A; 1H12 A; 4BOJ A; 4V1S A; 2FUQ A; 2PN5 A; 3E33 B; 1KSD A; 1GAI A; 3RJ3 A; 1O6H A; 2G02 A; 3PZ2 B; 3M74 A; 1K72 A; 3KQ4 A; 1FPP B; 3DST B; 3QFZ A; 1H36 A; 3HXE B; 3QDE A; 2VN7 A; 4FJQ A; 1IA7 A; 4WVA A; 3EQA A; 1O1S B; 3S9V A; 1QAZ A; 3EU5 B; 4CJ1 A; 4MBG B; 3KSQ B; 3QXF A; 1QBQ B; 5EAS A; 5ILJ A; 4D4B A; 1DL2 A; 1SA4 B; 1JCR B; 1N1Z A; 1O1T B; 4TXT A; 4WVB A; 1JS4 A; 1D8D B; 5FO9 B; 3A0O A; 4GTO B; 4DOE A; 4ZG8 A; 3G6J B; 5GZK A; 4FNV A; 4AYR A; 5IK6 A; 5CD2 A; 5ILD A; 2BBC A; 5JPN B; 4KTR A; 3N0G A; 2XWB B; 2XQW A; 3QG0 A; 3QT3 A; 1G87 A; 5DHK A; 1CEM A; 3W7T A; 3K11 A; 3WKH A; 1TNO B; 2Q1F A; 3S4D A; 1VD5 A; 1TNU B; 4F13 A; 3PZ1 B; 5KKB A; 1G6I A; 2GZ6 A; 2RI8 A; 2WIN B; 2D5J A; 4Q88 A; 1OJM A; 1HN0 A; 3E37 B; 3GLY A; 3E7J A; 1KSC A; 1HXC A; 1XWT A; 1HM2 A; 2RI9 A; 3M72 A; 1RWC A; 1X1I A; 3WKG A; 3RX5 A; 1N24 A; 5MEH A; 2FBA A; 1UG9 A; 3D5S A; 4TF4 A; 1WZZ A; 3ON6 A; 1QQF A; 2ZZR A; 3DRA B; 3QT9 A; 2ZIS B; 1W6J A; 1SA5 B; 4KKI A; 3AFJ A; 3VW5 A; #chains in the Genus database with same CATH homology 1G9J A; 4J5T A; 4C1S A; 3SDT A; 2NOJ A; 2B39 A; 4Q2B A; 1O6Q A; 1GLM A; 1V7W A; 4AYP A; 3S4C A; 4M76 A; 1GXN A; 1C3D A; 4FXG B; 3M76 A; 3VXD A; 1W6K A; 2WY7 A; 5FO7 B; 5M7I A; 1UT9 A; 1FBW A; 1KZO B; 1X81 B; 5M7Y A; 1X9D A; 1HZF A; 1TN8 B; 2H6H B; 3DSS B; 3P5R A; 1V5C A; 4CE7 A; 4DOD A; 5AGD A; 3M77 A; 1N4P B; 4FXK B; 4L9P B; 4GTV B; 2JG0 A; 4XUV A; 2RGK A; 2BB5 A; 4KTP A; 1WU6 A; 3KLS A; 1GSZ A; 1LF9 A; 3K7X A; 1G9G A; 2A73 B; 5DGR A; 4Z4L A; 3E73 A; 3WKI A; 2G0D A; 1UMP A; 1TNZ B; 1RQ5 A; 3EUV B; 1N95 B; 1CLC A; 2JF4 A; 3H3K A; 1GXM A; 2NVP A; 1FP3 A; 2DRQ A; 3M7C A; 4JJJ A; 4GTS B; 1FCE A; 4KKJ A; 2AFA A; 1IA6 A; 5DGQ A; 1GHQ A; 2H6F B; 5GW7 A; 1N4S B; 3QWT A; 1S63 B; 3ANJ A; 3SQC A; 3Q7A B; 1FT1 B; 3EU8 A; 3WC3 A; 4GTM B; 2XFG A; 3TF4 A; 3H7L A; 3CU7 A; 4FUS A; 3T33 A; 1F9D A; 2SQC A; 2ZBL A; 2IEJ B; 3PYB A; 3X17 A; 1KRF A; 3W5M A; 2FV0 A; 1L1Y A; 3KSL B; 3WIW A; 1LF6 A; 1NC5 A; 2Z07 A; 1TF4 A; 2B4F A; 1H3C A; 3W5N A; 1N4R B; 2WY8 A; 5FOB B; 2DRO A; 1GA2 A; 3RSY A; 4GTR B; 3OED A; 3CIH A; 2VN4 A; 3HXB B; 2I07 B; 5FO8 B; 3M75 A; 2YIK A; 4ZRQ A; 1WU4 A; 3GT5 A; 1FO3 A; 1H39 A; 4YDO B; 3W7S A; 2EAC A; 1TNY B; 3S4A A; 2XWJ B; 4WU0 A; 3ANI A; 1H3A A; 1JCS B; 3E30 B; 3C72 B; 3EZ8 A; 3P5P A; 3Q78 B; 3OXU A; 3A3V A; 4LNV A; 5CZL A; 1AGM A; 3E34 B; 5E2J A; 1O5M B; 3WIR A; 2AHG A; 1KRE A; 3DSX B; 3PZ4 B; 3QFY A; 4ZRP A; 2BB6 A; 1H35 A; 2ZIR B; 1H3B A; 1LTX B; 2V3N A; 3SDR A; 2QNO A; 1DOG A; 4Z4J A; 3GZK A; 3RX8 A; 2OKX A; 1KKT A; 3D3I A; 1N9A B; 3DPY B; 1NXC A; 3M71 A; 3SDU A; 3M7L A; 4D4D A; 1QSJ A; 3ACS A; 5JPM B; 1LD7 B; 4GL3 A; 1IS9 A; 4GTQ B; 4L0G A; 4EHM B; 4ZH1 A; 4V1R A; 3SDV A; 1FT2 B; 1JCQ B; 1HCU A; 1ULV A; 2FV1 A; 1AYX A; 1S64 B; 4EL8 A; 3W7W A; 3Q79 B; 3DSW B; 3QPF A; 3H2W A; 2EAE A; 1GXO A; 3DSU B; 3Q7F B; 3HXF B; 4GTT B; 4D4A A; 2V8K A; 4L6X A; 3ANK A; 3QXQ A; 3HXD B; 3W7U A; 4MU9 A; 2EAB A; 1XW2 A; 1H54 A; 1N4Q B; 2H6G B; 3P2C A; 2PMV A; 3D5R A; 4BOK A; 1TN7 B; 1MZC B; 3M7B A; 1O1R B; 3M73 A; 1O79 A; 1FBO A; 1KS8 A; 2V8J A; 2P0V A; 3QSP A; 1H14 A; 1SQC A; 4D94 A; 2V8I A; 2V3P A; 2F0Y B; 1H37 A; 1N94 B; 2A8Z A; 4LNB B; 3WIQ A; 2CQT A; 3RX7 A; 3HXC B; 4D4C A; 2H6I B; 2D8L A; 3M7E A; 2EAD A; 1FAE A; 1KFG A; 2WYN A; 3DSV B; 3SDQ A; 1TNB B; 1GAH A; 4WVC A; 5GY3 A; 4AYQ A; 1V5D A; 2FUZ A; 1KZP B; 3Q73 B; 1NL4 B; 3SFY B; 2AHF A; 4LIX A; 4QT9 A; 1L2A A; 2GOX A; 5CA3 A; 3S4B A; 1FO2 A; 3Q75 B; 1O6R A; 1F9O A; 2R2L B; 3W7X A; 2DRS A; 3M78 A; 4ONT A; 2JJB A; 3PMM A; 3RRS A; 1LD8 B; 3E32 B; 2WII B; 1V7X A; 3WKF A; 4AYO A; 3SFX B; 3E6U A; 3PYA A; 1KWF A; 1R76 A; 3REN A; 1NI1 B; 4LNG B; 1TN6 B; 3QRY A; 1H13 A; 1DCE B; 2DRR A; 2GH4 A; 3ACT A; 4CJ0 A; 4YDE B; 3SAE A; 1XWQ A; 1FMI A; 1D8E B; 4YCR A; 1WU5 A; 2BED B; 3PZ3 B; 2F6D A; 4GTP B; 1V7V A; 4ZH5 A; 2CQS A; 3WUX A; 1H12 A; 4BOJ A; 4V1S A; 2PN5 A; 3E33 B; 1KSD A; 1GAI A; 3RJ3 A; 1O6H A; 2G02 A; 3PZ2 B; 3M74 A; 1K72 A; 3KQ4 A; 1FPP B; 3DST B; 3QFZ A; 1H36 A; 3HXE B; 3QDE A; 2VN7 A; 1IA7 A; 4WVA A; 3EQA A; 1O1S B; 3S9V A; 3EU5 B; 4CJ1 A; 4MBG B; 3KSQ B; 3QXF A; 1QBQ B; 4D4B A; 1DL2 A; 1SA4 B; 1JCR B; 1O1T B; 4TXT A; 4WVB A; 1JS4 A; 1D8D B; 5FO9 B; 4GTO B; 4DOE A; 4ZG8 A; 3G6J B; 5GZK A; 4AYR A; 5CD2 A; 2BBC A; 5JPN B; 4KTR A; 2XWB B; 2XQW A; 3QG0 A; 3QT3 A; 1G87 A; 1CEM A; 3W7T A; 3K11 A; 3WKH A; 1TNO B; 3S4D A; 1VD5 A; 1TNU B; 3PZ1 B; 5KKB A; 1G6I A; 2GZ6 A; 2RI8 A; 2WIN B; 2D5J A; 4Q88 A; 3E37 B; 3GLY A; 1KSC A; 1XWT A; 2RI9 A; 3M72 A; 3WKG A; 3RX5 A; 5MEH A; 2FBA A; 1UG9 A; 3D5S A; 4TF4 A; 1WZZ A; 3ON6 A; 1QQF A; 2ZZR A; 3DRA B; 3QT9 A; 2ZIS B; 1W6J A; 1SA5 B; 4KKI A; 3AFJ A; 3VW5 A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
