1KH9A

E. coli alkaline phosphatase mutant (d153gd330n) complex with phosphate
Total Genus 144
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
Knots found
sequence length
444
structure length
444
Chain Sequence
b'VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Alkaline phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 144
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh9A00
4ZG6A 4CYRA 2GLQA 3UN5A 4MIVA 3T01A 1E1ZP 2D1GA 2IUCA 2XRGA 3Q3QA 1Y6VA 1ZEDA 4FDIA 1N2KA 4MHXA 3WAWA 5LRMA 2G9YA 2RH6A 3UN3A 3TX0A 1P49A 4UPLA 2W5WA 4UPIA 3IDDA 1HJKA 3M8WA 4MY4A 5GOVA 3M8YA 1URBA 1HQAA 4LR2A 2ZKTA 3LXQA 1B8JA 5LRNA 4KJDA 1HDHA 2W5TA 3UNYA 4TN0A 2W5SA 4ZG7A 1ALHA 3BDGA 1EJJA 1KH9A 4UPKA 2GSUA 5DLVA 1ED8A 4CXSA 3NKPA 4LRBA 4UOPA 3IGYB 3NKNA 1KH7A 3MK2A 3TG0A 1FSUA 4B56A 4LR9A 3NKOA 1AJDA 1EW9A 4GTZA 5INHA 1KH5A 2W5VA 3MK1A 1EW8A 3BDHA 4CXKA 1O98A 1K7HA 2W5XA 2XR9A 4NWXA 1AJCA 4UPHA 3NKMA 3BDFA 1E2SP 4ZG9A 1ELYA 4LRFA 1ELXA 4LRAA 1KH4A 1ZEBA 1ANIA 1EI6A 5L0EA 2W5QA 3MK0A 3TWZA 3M8ZA 5DLWA 4GTXA 1KHNA 3T02A 1ALJA 4LRCA 3WAYA 2GSOA 3E2DA 5LQQA 1E33P 1AUKA 3CMRA 4ZGAA 5GRRA 5TJ3A 1Y7AA 1ALKA 3ED4A 2W8SA 5DLTA 1ANJA 1KHJA 4KJGA 3A52A 1URAA 2W5RA 5EGHA 3WAXA 3SZZA 1KHLA 4KAYA 4LR7A 1EW2A 2X98A 4LR8A 5KXAA 5AJ9A 4NWJA 1O99A 3M7VA 4UORA 5IJQA 2IUCB 3KD8A 2GSNA 1ALIA 2IFYA 4LRDA 4QAXA 4GTWA 1ZEFA 3UO0A 3WBHA 3DPCA 4N7TA 2W8DA 2GA3A 1SHNA 3OT9A 4GTYA 5IJSA 1ELZA 1KHKA 1ED9A 3DYCA 5EGEA 3NKRA 5L0KA 3WAVA 4FDJA 3T00A 5HRTA 5L0BA 4CYSA 4KAVA 1EQJA 3BDGB 1SHQA 4YR1A 1N2LA 2QZUA 5LIAA 4UOOA 3UN2A 4CXUA 3IGZB 4KM4A 1AJBA 3SZYA 3NVLA 2ANHA 4LREA 4LQYA 1E3CP 5C66A 1AJAA 2VQRA 5K4PA 3NKQA 3B5QA
chains in the Genus database with same CATH superfamily
4ZG6A 4CYRA 2GLQA 3UN5A 4MIVA 3T01A 1E1ZP 2D1GA 2IUCA 2XRGA 3Q3QA 1Y6VA 1ZEDA 4FDIA 1N2KA 4MHXA 3WAWA 5LRMA 2G9YA 2RH6A 3UN3A 3TX0A 1P49A 4UPLA 2W5WA 4UPIA 3IDDA 1HJKA 3M8WA 4MY4A 5GOVA 3M8YA 1URBA 1HQAA 4LR2A 2ZKTA 3LXQA 1B8JA 5LRNA 4KJDA 1HDHA 2W5TA 3UNYA 4TN0A 2W5SA 4ZG7A 1ALHA 3BDGA 1EJJA 1KH9A 4UPKA 2GSUA 5DLVA 1ED8A 4CXSA 3NKPA 4LRBA 4UOPA 3IGYB 3NKNA 1KH7A 3MK2A 3TG0A 1FSUA 4B56A 4LR9A 3NKOA 1AJDA 1EW9A 4GTZA 5INHA 1KH5A 2W5VA 3MK1A 1EW8A 3BDHA 4CXKA 1O98A 1K7HA 2W5XA 2XR9A 4NWXA 1AJCA 4UPHA 3NKMA 3BDFA 1E2SP 4ZG9A 1ELYA 4LRFA 1ELXA 4LRAA 1KH4A 1ZEBA 1ANIA 1EI6A 5L0EA 2W5QA 3MK0A 3TWZA 3M8ZA 5DLWA 4GTXA 1KHNA 3T02A 1ALJA 4LRCA 3WAYA 2GSOA 3E2DA 5LQQA 1E33P 1AUKA 3CMRA 4ZGAA 5GRRA 5TJ3A 1Y7AA 1ALKA 3ED4A 2W8SA 5DLTA 1ANJA 1KHJA 4KJGA 3A52A 1URAA 2W5RA 5EGHA 3WAXA 3SZZA 1KHLA 4KAYA 4LR7A 1EW2A 2X98A 4LR8A 5KXAA 5AJ9A 4NWJA 1O99A 3M7VA 4UORA 5IJQA 2IUCB 3KD8A 2GSNA 1ALIA 2IFYA 4LRDA 4QAXA 4GTWA 1ZEFA 3UO0A 3WBHA 3DPCA 4N7TA 2W8DA 2GA3A 1SHNA 3OT9A 4GTYA 5IJSA 1ELZA 1KHKA 1ED9A 3DYCA 5EGEA 3NKRA 5L0KA 3WAVA 4FDJA 3T00A 5HRTA 5L0BA 4CYSA 4KAVA 1EQJA 3BDGB 1SHQA 4YR1A 1N2LA 2QZUA 5LIAA 4UOOA 3UN2A 4CXUA 3IGZB 4KM4A 1AJBA 3SZYA 3NVLA 2ANHA 4LREA 4LQYA 1E3CP 5C66A 1AJAA 2VQRA 5K4PA 3NKQA 3B5QA
chains in the Genus database with same CATH topology
4ZG6A 4CYRA 2GLQA 3UN5A 4MIVA 3T01A 1E1ZP 2D1GA 2IUCA 2XRGA 3Q3QA 1Y6VA 1ZEDA 4FDIA 1N2KA 4MHXA 3WAWA 5LRMA 2G9YA 2RH6A 3UN3A 3TX0A 1P49A 4UPLA 2W5WA 4UPIA 3IDDA 1HJKA 3M8WA 4MY4A 5GOVA 3M8YA 1URBA 1HQAA 4LR2A 2ZKTA 3LXQA 1B8JA 5LRNA 4KJDA 1HDHA 2W5TA 3UNYA 4TN0A 2W5SA 4ZG7A 1ALHA 3BDGA 1EJJA 1KH9A 4UPKA 2GSUA 5DLVA 1ED8A 4CXSA 3NKPA 4LRBA 4UOPA 3IGYB 3NKNA 1KH7A 3MK2A 3TG0A 1FSUA 4B56A 4LR9A 3NKOA 1AJDA 1EW9A 4GTZA 5INHA 1KH5A 2W5VA 3MK1A 1EW8A 3BDHA 4CXKA 1O98A 1K7HA 2W5XA 2XR9A 4NWXA 1AJCA 4UPHA 3NKMA 3BDFA 1E2SP 4ZG9A 1ELYA 4LRFA 1ELXA 4LRAA 1KH4A 1ZEBA 1ANIA 1EI6A 5L0EA 2W5QA 3MK0A 3TWZA 3M8ZA 5DLWA 4GTXA 1KHNA 3T02A 1ALJA 4LRCA 3WAYA 2GSOA 3E2DA 5LQQA 1E33P 1AUKA 3CMRA 4ZGAA 5GRRA 5TJ3A 1Y7AA 1ALKA 3ED4A 2W8SA 5DLTA 1ANJA 1KHJA 4KJGA 3A52A 1URAA 2W5RA 5EGHA 3WAXA 3SZZA 1KHLA 4KAYA 4LR7A 1EW2A 2X98A 4LR8A 5KXAA 5AJ9A 4NWJA 1O99A 3M7VA 4UORA 5IJQA 2IUCB 3KD8A 2GSNA 1ALIA 2IFYA 4LRDA 4QAXA 4GTWA 1ZEFA 3UO0A 3WBHA 3DPCA 4N7TA 2W8DA 2GA3A 1SHNA 3OT9A 4GTYA 5IJSA 1ELZA 1KHKA 1ED9A 3DYCA 5EGEA 3NKRA 5L0KA 3WAVA 4FDJA 3T00A 5HRTA 5L0BA 4CYSA 4KAVA 1EQJA 3BDGB 1SHQA 4YR1A 1N2LA 2QZUA 5LIAA 4UOOA 3UN2A 4CXUA 3IGZB 4KM4A 1AJBA 3SZYA 3NVLA 2ANHA 4LREA 4LQYA 1E3CP 5C66A 1AJAA 2VQRA 5K4PA 3NKQA 3B5QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZG6 A;  4CYR A;  2GLQ A;  3UN5 A;  4MIV A;  3T01 A;  1E1Z P;  2D1G A;  2IUC A;  2XRG A;  3Q3Q A;  1Y6V A;  1ZED A;  4FDI A;  1N2K A;  4MHX A;  3WAW A;  5LRM A;  2G9Y A;  2RH6 A;  3UN3 A;  3TX0 A;  1P49 A;  4UPL A;  2W5W A;  4UPI A;  3IDD A;  1HJK A;  3M8W A;  4MY4 A;  5GOV A;  3M8Y A;  1URB A;  1HQA A;  4LR2 A;  2ZKT A;  3LXQ A;  1B8J A;  5LRN A;  4KJD A;  1HDH A;  2W5T A;  3UNY A;  4TN0 A;  2W5S A;  4ZG7 A;  1ALH A;  3BDG A;  1EJJ A;  1KH9 A;  4UPK A;  2GSU A;  5DLV A;  1ED8 A;  4CXS A;  3NKP A;  4LRB A;  4UOP A;  3IGY B;  3NKN A;  1KH7 A;  3MK2 A;  3TG0 A;  1FSU A;  4B56 A;  4LR9 A;  3NKO A;  1AJD A;  1EW9 A;  4GTZ A;  5INH A;  1KH5 A;  2W5V A;  3MK1 A;  1EW8 A;  3BDH A;  4CXK A;  1O98 A;  1K7H A;  2W5X A;  2XR9 A;  4NWX A;  1AJC A;  4UPH A;  3NKM A;  3BDF A;  1E2S P;  4ZG9 A;  1ELY A;  4LRF A;  1ELX A;  4LRA A;  1KH4 A;  1ZEB A;  1ANI A;  1EI6 A;  5L0E A;  2W5Q A;  3MK0 A;  3TWZ A;  3M8Z A;  5DLW A;  4GTX A;  1KHN A;  3T02 A;  1ALJ A;  4LRC A;  3WAY A;  2GSO A;  3E2D A;  5LQQ A;  1E33 P;  1AUK A;  3CMR A;  4ZGA A;  5GRR A;  5TJ3 A;  1Y7A A;  1ALK A;  3ED4 A;  2W8S A;  5DLT A;  1ANJ A;  1KHJ A;  4KJG A;  3A52 A;  1URA A;  2W5R A;  5EGH A;  3WAX A;  3SZZ A;  1KHL A;  4KAY A;  4LR7 A;  1EW2 A;  2X98 A;  4LR8 A;  5KXA A;  5AJ9 A;  4NWJ A;  1O99 A;  3M7V A;  4UOR A;  5IJQ A;  2IUC B;  3KD8 A;  2GSN A;  1ALI A;  2IFY A;  4LRD A;  4QAX A;  4GTW A;  1ZEF A;  3UO0 A;  3WBH A;  3DPC A;  4N7T A;  2W8D A;  2GA3 A;  1SHN A;  3OT9 A;  4GTY A;  5IJS A;  1ELZ A;  1KHK A;  1ED9 A;  3DYC A;  5EGE A;  3NKR A;  5L0K A;  3WAV A;  4FDJ A;  3T00 A;  5HRT A;  5L0B A;  4CYS A;  4KAV A;  1EQJ A;  3BDG B;  1SHQ A;  4YR1 A;  1N2L A;  2QZU A;  5LIA A;  4UOO A;  3UN2 A;  4CXU A;  3IGZ B;  4KM4 A;  1AJB A;  3SZY A;  3NVL A;  2ANH A;  4LRE A;  4LQY A;  1E3C P;  5C66 A;  1AJA A;  2VQR A;  5K4P A;  3NKQ A;  3B5Q A; 
#chains in the Genus database with same CATH topology
 4ZG6 A;  4CYR A;  2GLQ A;  3UN5 A;  4MIV A;  3T01 A;  1E1Z P;  2D1G A;  2IUC A;  2XRG A;  3Q3Q A;  1Y6V A;  1ZED A;  4FDI A;  1N2K A;  4MHX A;  3WAW A;  5LRM A;  2G9Y A;  2RH6 A;  3UN3 A;  3TX0 A;  1P49 A;  4UPL A;  2W5W A;  4UPI A;  3IDD A;  1HJK A;  3M8W A;  4MY4 A;  5GOV A;  3M8Y A;  1URB A;  1HQA A;  4LR2 A;  2ZKT A;  3LXQ A;  1B8J A;  5LRN A;  4KJD A;  1HDH A;  2W5T A;  3UNY A;  4TN0 A;  2W5S A;  4ZG7 A;  1ALH A;  3BDG A;  1EJJ A;  1KH9 A;  4UPK A;  2GSU A;  5DLV A;  1ED8 A;  4CXS A;  3NKP A;  4LRB A;  4UOP A;  3IGY B;  3NKN A;  1KH7 A;  3MK2 A;  3TG0 A;  1FSU A;  4B56 A;  4LR9 A;  3NKO A;  1AJD A;  1EW9 A;  4GTZ A;  5INH A;  1KH5 A;  2W5V A;  3MK1 A;  1EW8 A;  3BDH A;  4CXK A;  1O98 A;  1K7H A;  2W5X A;  2XR9 A;  4NWX A;  1AJC A;  4UPH A;  3NKM A;  3BDF A;  1E2S P;  4ZG9 A;  1ELY A;  4LRF A;  1ELX A;  4LRA A;  1KH4 A;  1ZEB A;  1ANI A;  1EI6 A;  5L0E A;  2W5Q A;  3MK0 A;  3TWZ A;  3M8Z A;  5DLW A;  4GTX A;  1KHN A;  3T02 A;  1ALJ A;  4LRC A;  3WAY A;  2GSO A;  3E2D A;  5LQQ A;  1E33 P;  1AUK A;  3CMR A;  4ZGA A;  5GRR A;  5TJ3 A;  1Y7A A;  1ALK A;  3ED4 A;  2W8S A;  5DLT A;  1ANJ A;  1KHJ A;  4KJG A;  3A52 A;  1URA A;  2W5R A;  5EGH A;  3WAX A;  3SZZ A;  1KHL A;  4KAY A;  4LR7 A;  1EW2 A;  2X98 A;  4LR8 A;  5KXA A;  5AJ9 A;  4NWJ A;  1O99 A;  3M7V A;  4UOR A;  5IJQ A;  2IUC B;  3KD8 A;  2GSN A;  1ALI A;  2IFY A;  4LRD A;  4QAX A;  4GTW A;  1ZEF A;  3UO0 A;  3WBH A;  3DPC A;  4N7T A;  2W8D A;  2GA3 A;  1SHN A;  3OT9 A;  4GTY A;  5IJS A;  1ELZ A;  1KHK A;  1ED9 A;  3DYC A;  5EGE A;  3NKR A;  5L0K A;  3WAV A;  4FDJ A;  3T00 A;  5HRT A;  5L0B A;  4CYS A;  4KAV A;  1EQJ A;  3BDG B;  1SHQ A;  4YR1 A;  1N2L A;  2QZU A;  5LIA A;  4UOO A;  3UN2 A;  4CXU A;  3IGZ B;  4KM4 A;  1AJB A;  3SZY A;  3NVL A;  2ANH A;  4LRE A;  4LQY A;  1E3C P;  5C66 A;  1AJA A;  2VQR A;  5K4P A;  3NKQ A;  3B5Q A; 
#chains in the Genus database with same CATH homology
 4ZG6 A;  4CYR A;  2GLQ A;  3UN5 A;  4MIV A;  3T01 A;  1E1Z P;  2D1G A;  2IUC A;  2XRG A;  3Q3Q A;  1Y6V A;  1ZED A;  4FDI A;  1N2K A;  4MHX A;  3WAW A;  5LRM A;  2G9Y A;  2RH6 A;  3UN3 A;  3TX0 A;  1P49 A;  4UPL A;  2W5W A;  4UPI A;  3IDD A;  1HJK A;  3M8W A;  4MY4 A;  5GOV A;  3M8Y A;  1URB A;  1HQA A;  4LR2 A;  2ZKT A;  3LXQ A;  1B8J A;  5LRN A;  4KJD A;  1HDH A;  2W5T A;  3UNY A;  4TN0 A;  2W5S A;  4ZG7 A;  1ALH A;  3BDG A;  1EJJ A;  1KH9 A;  4UPK A;  2GSU A;  5DLV A;  1ED8 A;  4CXS A;  3NKP A;  4LRB A;  4UOP A;  3IGY B;  3NKN A;  1KH7 A;  3MK2 A;  3TG0 A;  1FSU A;  4B56 A;  4LR9 A;  3NKO A;  1AJD A;  1EW9 A;  4GTZ A;  5INH A;  1KH5 A;  2W5V A;  3MK1 A;  1EW8 A;  3BDH A;  4CXK A;  1O98 A;  1K7H A;  2W5X A;  2XR9 A;  4NWX A;  1AJC A;  4UPH A;  3NKM A;  3BDF A;  1E2S P;  4ZG9 A;  1ELY A;  4LRF A;  1ELX A;  4LRA A;  1KH4 A;  1ZEB A;  1ANI A;  1EI6 A;  5L0E A;  2W5Q A;  3MK0 A;  3TWZ A;  3M8Z A;  5DLW A;  4GTX A;  1KHN A;  3T02 A;  1ALJ A;  4LRC A;  3WAY A;  2GSO A;  3E2D A;  5LQQ A;  1E33 P;  1AUK A;  3CMR A;  4ZGA A;  5GRR A;  5TJ3 A;  1Y7A A;  1ALK A;  3ED4 A;  2W8S A;  5DLT A;  1ANJ A;  1KHJ A;  4KJG A;  3A52 A;  1URA A;  2W5R A;  5EGH A;  3WAX A;  3SZZ A;  1KHL A;  4KAY A;  4LR7 A;  1EW2 A;  2X98 A;  4LR8 A;  5KXA A;  5AJ9 A;  4NWJ A;  1O99 A;  3M7V A;  4UOR A;  5IJQ A;  2IUC B;  3KD8 A;  2GSN A;  1ALI A;  2IFY A;  4LRD A;  4QAX A;  4GTW A;  1ZEF A;  3UO0 A;  3WBH A;  3DPC A;  4N7T A;  2W8D A;  2GA3 A;  1SHN A;  3OT9 A;  4GTY A;  5IJS A;  1ELZ A;  1KHK A;  1ED9 A;  3DYC A;  5EGE A;  3NKR A;  5L0K A;  3WAV A;  4FDJ A;  3T00 A;  5HRT A;  5L0B A;  4CYS A;  4KAV A;  1EQJ A;  3BDG B;  1SHQ A;  4YR1 A;  1N2L A;  2QZU A;  5LIA A;  4UOO A;  3UN2 A;  4CXU A;  3IGZ B;  4KM4 A;  1AJB A;  3SZY A;  3NVL A;  2ANH A;  4LRE A;  4LQY A;  1E3C P;  5C66 A;  1AJA A;  2VQR A;  5K4P A;  3NKQ A;  3B5Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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