1KHJA

E. coli alkaline phosphatase mutant (d153hd330n) mimic of the transition states with aluminium fluoride
Total Genus 156
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
156
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Alkaline phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
total genus 156
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khjA00
2GSNA 1HJKA 4LR7A 4KM4A 1ED8A 3BDFA 4GTZA 4UPLA 3OT9A 4LRBA 1E2SP 3TWZA 3WBHA 1ALIA 3UN5A 4CYRA 5TJ3A 5IJSA 3Q3QA 3LXQA 3M8ZA 3MK0A 2IUCA 2XR9A 3DPCA 3NKNA 4FDJA 4LRFA 3WAXA 5GRRA 1K7HA 3TG0A 4CXSA 3WAWA 2W5WA 1KH4A 4LR2A 4UPKA 4GTXA 1ZEFA 2W5VA 3MK2A 3M8YA 3UNYA 4LR9A 1B8JA 4CXUA 2IUCB 1AJAA 3E2DA 1EQJA 4KAVA 5EGHA 4LQYA 3IGZB 5LRMA 4B56A 4TN0A 1KHLA 4UORA 2X98A 3SZZA 5L0KA 2W8DA 1ANJA 4ZG7A 5C66A 3NKMA 4UOOA 2GSOA 5KXAA 5IJQA 1EJJA 2XRGA 4CYSA 3BDHA 4LRCA 4ZG6A 4ZG9A 1SHNA 5K4PA 3IGYB 2W5SA 3CMRA 2ZKTA 3WAVA 2G9YA 3DYCA 5DLVA 4FDIA 1SHQA 4LRAA 3KD8A 4KJGA 2GSUA 3BDGA 1P49A 1KHKA 1KHJA 1AJCA 1URAA 3ED4A 4GTYA 4MHXA 1AJBA 1O98A 2GA3A 3NKQA 1KH9A 2RH6A 3T01A 5L0BA 2VQRA 1ELZA 3NKRA 4UPHA 3M8WA 3BDGB 4NWJA 4GTWA 1Y7AA 2W8SA 5LRNA 4LR8A 1HDHA 5LIAA 1AUKA 1EW8A 1ZEBA 3T00A 4KJDA 5DLWA 4ZGAA 2D1GA 1AJDA 4MY4A 1EW9A 1EW2A 3B5QA 5AJ9A 1ELXA 2W5QA 4YR1A 2IFYA 1ALHA 5GOVA 3TX0A 1N2KA 5INHA 4KAYA 4NWXA 2QZUA 4UPIA 5L0EA 1E1ZP 1E33P 1KH5A 2ANHA 3A52A 5HRTA 1EI6A 3NKOA 3WAYA 3IDDA 3SZYA 1ELYA 3M7VA 1ZEDA 5DLTA 1O99A 3MK1A 4CXKA 4QAXA 1Y6VA 1ED9A 1ALJA 1KH7A 2W5XA 1HQAA 3NVLA 2GLQA 2W5TA 3NKPA 3UO0A 1N2LA 3UN3A 1URBA 1KHNA 4LRDA 1FSUA 1ALKA 4N7TA 1E3CP 2W5RA 4LREA 4UOPA 5EGEA 5LQQA 1ANIA 3UN2A 3T02A 4MIVA
chains in the Genus database with same CATH superfamily
2GSNA 1HJKA 4LR7A 4KM4A 1ED8A 3BDFA 4GTZA 4UPLA 3OT9A 4LRBA 1E2SP 3TWZA 3WBHA 1ALIA 3UN5A 4CYRA 5TJ3A 5IJSA 3Q3QA 3LXQA 3M8ZA 3MK0A 2IUCA 2XR9A 3DPCA 3NKNA 4FDJA 4LRFA 3WAXA 5GRRA 1K7HA 3TG0A 4CXSA 3WAWA 2W5WA 1KH4A 4LR2A 4UPKA 4GTXA 1ZEFA 2W5VA 3MK2A 3M8YA 3UNYA 4LR9A 1B8JA 4CXUA 2IUCB 1AJAA 3E2DA 1EQJA 4KAVA 5EGHA 4LQYA 3IGZB 5LRMA 4B56A 4TN0A 1KHLA 4UORA 2X98A 3SZZA 5L0KA 2W8DA 1ANJA 4ZG7A 5C66A 3NKMA 4UOOA 2GSOA 5KXAA 5IJQA 1EJJA 2XRGA 4CYSA 3BDHA 4LRCA 4ZG6A 4ZG9A 1SHNA 5K4PA 3IGYB 2W5SA 3CMRA 2ZKTA 3WAVA 2G9YA 3DYCA 5DLVA 4FDIA 1SHQA 4LRAA 3KD8A 4KJGA 2GSUA 3BDGA 1P49A 1KHKA 1KHJA 1AJCA 1URAA 3ED4A 4GTYA 4MHXA 1AJBA 1O98A 2GA3A 3NKQA 1KH9A 2RH6A 3T01A 5L0BA 2VQRA 1ELZA 3NKRA 4UPHA 3M8WA 3BDGB 4NWJA 4GTWA 1Y7AA 2W8SA 5LRNA 4LR8A 1HDHA 5LIAA 1AUKA 1EW8A 1ZEBA 3T00A 4KJDA 5DLWA 4ZGAA 2D1GA 1AJDA 4MY4A 1EW9A 1EW2A 3B5QA 5AJ9A 1ELXA 2W5QA 4YR1A 2IFYA 1ALHA 5GOVA 3TX0A 1N2KA 5INHA 4KAYA 4NWXA 2QZUA 4UPIA 5L0EA 1E1ZP 1E33P 1KH5A 2ANHA 3A52A 5HRTA 1EI6A 3NKOA 3WAYA 3IDDA 3SZYA 1ELYA 3M7VA 1ZEDA 5DLTA 1O99A 3MK1A 4CXKA 4QAXA 1Y6VA 1ED9A 1ALJA 1KH7A 2W5XA 1HQAA 3NVLA 2GLQA 2W5TA 3NKPA 3UO0A 1N2LA 3UN3A 1URBA 1KHNA 4LRDA 1FSUA 1ALKA 4N7TA 1E3CP 2W5RA 4LREA 4UOPA 5EGEA 5LQQA 1ANIA 3UN2A 3T02A 4MIVA
chains in the Genus database with same CATH topology
2GSNA 1HJKA 4LR7A 4KM4A 1ED8A 3BDFA 4GTZA 4UPLA 3OT9A 4LRBA 1E2SP 3TWZA 3WBHA 1ALIA 3UN5A 4CYRA 5TJ3A 5IJSA 3Q3QA 3LXQA 3M8ZA 3MK0A 2IUCA 2XR9A 3DPCA 3NKNA 4FDJA 4LRFA 3WAXA 5GRRA 1K7HA 3TG0A 4CXSA 3WAWA 2W5WA 1KH4A 4LR2A 4UPKA 4GTXA 1ZEFA 2W5VA 3MK2A 3M8YA 3UNYA 4LR9A 1B8JA 4CXUA 2IUCB 1AJAA 3E2DA 1EQJA 4KAVA 5EGHA 4LQYA 3IGZB 5LRMA 4B56A 4TN0A 1KHLA 4UORA 2X98A 3SZZA 5L0KA 2W8DA 1ANJA 4ZG7A 5C66A 3NKMA 4UOOA 2GSOA 5KXAA 5IJQA 1EJJA 2XRGA 4CYSA 3BDHA 4LRCA 4ZG6A 4ZG9A 1SHNA 5K4PA 3IGYB 2W5SA 3CMRA 2ZKTA 3WAVA 2G9YA 3DYCA 5DLVA 4FDIA 1SHQA 4LRAA 3KD8A 4KJGA 2GSUA 3BDGA 1P49A 1KHKA 1KHJA 1AJCA 1URAA 3ED4A 4GTYA 4MHXA 1AJBA 1O98A 2GA3A 3NKQA 1KH9A 2RH6A 3T01A 5L0BA 2VQRA 1ELZA 3NKRA 4UPHA 3M8WA 3BDGB 4NWJA 4GTWA 1Y7AA 2W8SA 5LRNA 4LR8A 1HDHA 5LIAA 1AUKA 1EW8A 1ZEBA 3T00A 4KJDA 5DLWA 4ZGAA 2D1GA 1AJDA 4MY4A 1EW9A 1EW2A 3B5QA 5AJ9A 1ELXA 2W5QA 4YR1A 2IFYA 1ALHA 5GOVA 3TX0A 1N2KA 5INHA 4KAYA 4NWXA 2QZUA 4UPIA 5L0EA 1E1ZP 1E33P 1KH5A 2ANHA 3A52A 5HRTA 1EI6A 3NKOA 3WAYA 3IDDA 3SZYA 1ELYA 3M7VA 1ZEDA 5DLTA 1O99A 3MK1A 4CXKA 4QAXA 1Y6VA 1ED9A 1ALJA 1KH7A 2W5XA 1HQAA 3NVLA 2GLQA 2W5TA 3NKPA 3UO0A 1N2LA 3UN3A 1URBA 1KHNA 4LRDA 1FSUA 1ALKA 4N7TA 1E3CP 2W5RA 4LREA 4UOPA 5EGEA 5LQQA 1ANIA 3UN2A 3T02A 4MIVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GSN A;  1HJK A;  4LR7 A;  4KM4 A;  1ED8 A;  3BDF A;  4GTZ A;  4UPL A;  3OT9 A;  4LRB A;  1E2S P;  3TWZ A;  3WBH A;  1ALI A;  3UN5 A;  4CYR A;  5TJ3 A;  5IJS A;  3Q3Q A;  3LXQ A;  3M8Z A;  3MK0 A;  2IUC A;  2XR9 A;  3DPC A;  3NKN A;  4FDJ A;  4LRF A;  3WAX A;  5GRR A;  1K7H A;  3TG0 A;  4CXS A;  3WAW A;  2W5W A;  1KH4 A;  4LR2 A;  4UPK A;  4GTX A;  1ZEF A;  2W5V A;  3MK2 A;  3M8Y A;  3UNY A;  4LR9 A;  1B8J A;  4CXU A;  2IUC B;  1AJA A;  3E2D A;  1EQJ A;  4KAV A;  5EGH A;  4LQY A;  3IGZ B;  5LRM A;  4B56 A;  4TN0 A;  1KHL A;  4UOR A;  2X98 A;  3SZZ A;  5L0K A;  2W8D A;  1ANJ A;  4ZG7 A;  5C66 A;  3NKM A;  4UOO A;  2GSO A;  5KXA A;  5IJQ A;  1EJJ A;  2XRG A;  4CYS A;  3BDH A;  4LRC A;  4ZG6 A;  4ZG9 A;  1SHN A;  5K4P A;  3IGY B;  2W5S A;  3CMR A;  2ZKT A;  3WAV A;  2G9Y A;  3DYC A;  5DLV A;  4FDI A;  1SHQ A;  4LRA A;  3KD8 A;  4KJG A;  2GSU A;  3BDG A;  1P49 A;  1KHK A;  1KHJ A;  1AJC A;  1URA A;  3ED4 A;  4GTY A;  4MHX A;  1AJB A;  1O98 A;  2GA3 A;  3NKQ A;  1KH9 A;  2RH6 A;  3T01 A;  5L0B A;  2VQR A;  1ELZ A;  3NKR A;  4UPH A;  3M8W A;  3BDG B;  4NWJ A;  4GTW A;  1Y7A A;  2W8S A;  5LRN A;  4LR8 A;  1HDH A;  5LIA A;  1AUK A;  1EW8 A;  1ZEB A;  3T00 A;  4KJD A;  5DLW A;  4ZGA A;  2D1G A;  1AJD A;  4MY4 A;  1EW9 A;  1EW2 A;  3B5Q A;  5AJ9 A;  1ELX A;  2W5Q A;  4YR1 A;  2IFY A;  1ALH A;  5GOV A;  3TX0 A;  1N2K A;  5INH A;  4KAY A;  4NWX A;  2QZU A;  4UPI A;  5L0E A;  1E1Z P;  1E33 P;  1KH5 A;  2ANH A;  3A52 A;  5HRT A;  1EI6 A;  3NKO A;  3WAY A;  3IDD A;  3SZY A;  1ELY A;  3M7V A;  1ZED A;  5DLT A;  1O99 A;  3MK1 A;  4CXK A;  4QAX A;  1Y6V A;  1ED9 A;  1ALJ A;  1KH7 A;  2W5X A;  1HQA A;  3NVL A;  2GLQ A;  2W5T A;  3NKP A;  3UO0 A;  1N2L A;  3UN3 A;  1URB A;  1KHN A;  4LRD A;  1FSU A;  1ALK A;  4N7T A;  1E3C P;  2W5R A;  4LRE A;  4UOP A;  5EGE A;  5LQQ A;  1ANI A;  3UN2 A;  3T02 A;  4MIV A; 
#chains in the Genus database with same CATH topology
 2GSN A;  1HJK A;  4LR7 A;  4KM4 A;  1ED8 A;  3BDF A;  4GTZ A;  4UPL A;  3OT9 A;  4LRB A;  1E2S P;  3TWZ A;  3WBH A;  1ALI A;  3UN5 A;  4CYR A;  5TJ3 A;  5IJS A;  3Q3Q A;  3LXQ A;  3M8Z A;  3MK0 A;  2IUC A;  2XR9 A;  3DPC A;  3NKN A;  4FDJ A;  4LRF A;  3WAX A;  5GRR A;  1K7H A;  3TG0 A;  4CXS A;  3WAW A;  2W5W A;  1KH4 A;  4LR2 A;  4UPK A;  4GTX A;  1ZEF A;  2W5V A;  3MK2 A;  3M8Y A;  3UNY A;  4LR9 A;  1B8J A;  4CXU A;  2IUC B;  1AJA A;  3E2D A;  1EQJ A;  4KAV A;  5EGH A;  4LQY A;  3IGZ B;  5LRM A;  4B56 A;  4TN0 A;  1KHL A;  4UOR A;  2X98 A;  3SZZ A;  5L0K A;  2W8D A;  1ANJ A;  4ZG7 A;  5C66 A;  3NKM A;  4UOO A;  2GSO A;  5KXA A;  5IJQ A;  1EJJ A;  2XRG A;  4CYS A;  3BDH A;  4LRC A;  4ZG6 A;  4ZG9 A;  1SHN A;  5K4P A;  3IGY B;  2W5S A;  3CMR A;  2ZKT A;  3WAV A;  2G9Y A;  3DYC A;  5DLV A;  4FDI A;  1SHQ A;  4LRA A;  3KD8 A;  4KJG A;  2GSU A;  3BDG A;  1P49 A;  1KHK A;  1KHJ A;  1AJC A;  1URA A;  3ED4 A;  4GTY A;  4MHX A;  1AJB A;  1O98 A;  2GA3 A;  3NKQ A;  1KH9 A;  2RH6 A;  3T01 A;  5L0B A;  2VQR A;  1ELZ A;  3NKR A;  4UPH A;  3M8W A;  3BDG B;  4NWJ A;  4GTW A;  1Y7A A;  2W8S A;  5LRN A;  4LR8 A;  1HDH A;  5LIA A;  1AUK A;  1EW8 A;  1ZEB A;  3T00 A;  4KJD A;  5DLW A;  4ZGA A;  2D1G A;  1AJD A;  4MY4 A;  1EW9 A;  1EW2 A;  3B5Q A;  5AJ9 A;  1ELX A;  2W5Q A;  4YR1 A;  2IFY A;  1ALH A;  5GOV A;  3TX0 A;  1N2K A;  5INH A;  4KAY A;  4NWX A;  2QZU A;  4UPI A;  5L0E A;  1E1Z P;  1E33 P;  1KH5 A;  2ANH A;  3A52 A;  5HRT A;  1EI6 A;  3NKO A;  3WAY A;  3IDD A;  3SZY A;  1ELY A;  3M7V A;  1ZED A;  5DLT A;  1O99 A;  3MK1 A;  4CXK A;  4QAX A;  1Y6V A;  1ED9 A;  1ALJ A;  1KH7 A;  2W5X A;  1HQA A;  3NVL A;  2GLQ A;  2W5T A;  3NKP A;  3UO0 A;  1N2L A;  3UN3 A;  1URB A;  1KHN A;  4LRD A;  1FSU A;  1ALK A;  4N7T A;  1E3C P;  2W5R A;  4LRE A;  4UOP A;  5EGE A;  5LQQ A;  1ANI A;  3UN2 A;  3T02 A;  4MIV A; 
#chains in the Genus database with same CATH homology
 2GSN A;  1HJK A;  4LR7 A;  4KM4 A;  1ED8 A;  3BDF A;  4GTZ A;  4UPL A;  3OT9 A;  4LRB A;  1E2S P;  3TWZ A;  3WBH A;  1ALI A;  3UN5 A;  4CYR A;  5TJ3 A;  5IJS A;  3Q3Q A;  3LXQ A;  3M8Z A;  3MK0 A;  2IUC A;  2XR9 A;  3DPC A;  3NKN A;  4FDJ A;  4LRF A;  3WAX A;  5GRR A;  1K7H A;  3TG0 A;  4CXS A;  3WAW A;  2W5W A;  1KH4 A;  4LR2 A;  4UPK A;  4GTX A;  1ZEF A;  2W5V A;  3MK2 A;  3M8Y A;  3UNY A;  4LR9 A;  1B8J A;  4CXU A;  2IUC B;  1AJA A;  3E2D A;  1EQJ A;  4KAV A;  5EGH A;  4LQY A;  3IGZ B;  5LRM A;  4B56 A;  4TN0 A;  1KHL A;  4UOR A;  2X98 A;  3SZZ A;  5L0K A;  2W8D A;  1ANJ A;  4ZG7 A;  5C66 A;  3NKM A;  4UOO A;  2GSO A;  5KXA A;  5IJQ A;  1EJJ A;  2XRG A;  4CYS A;  3BDH A;  4LRC A;  4ZG6 A;  4ZG9 A;  1SHN A;  5K4P A;  3IGY B;  2W5S A;  3CMR A;  2ZKT A;  3WAV A;  2G9Y A;  3DYC A;  5DLV A;  4FDI A;  1SHQ A;  4LRA A;  3KD8 A;  4KJG A;  2GSU A;  3BDG A;  1P49 A;  1KHK A;  1KHJ A;  1AJC A;  1URA A;  3ED4 A;  4GTY A;  4MHX A;  1AJB A;  1O98 A;  2GA3 A;  3NKQ A;  1KH9 A;  2RH6 A;  3T01 A;  5L0B A;  2VQR A;  1ELZ A;  3NKR A;  4UPH A;  3M8W A;  3BDG B;  4NWJ A;  4GTW A;  1Y7A A;  2W8S A;  5LRN A;  4LR8 A;  1HDH A;  5LIA A;  1AUK A;  1EW8 A;  1ZEB A;  3T00 A;  4KJD A;  5DLW A;  4ZGA A;  2D1G A;  1AJD A;  4MY4 A;  1EW9 A;  1EW2 A;  3B5Q A;  5AJ9 A;  1ELX A;  2W5Q A;  4YR1 A;  2IFY A;  1ALH A;  5GOV A;  3TX0 A;  1N2K A;  5INH A;  4KAY A;  4NWX A;  2QZU A;  4UPI A;  5L0E A;  1E1Z P;  1E33 P;  1KH5 A;  2ANH A;  3A52 A;  5HRT A;  1EI6 A;  3NKO A;  3WAY A;  3IDD A;  3SZY A;  1ELY A;  3M7V A;  1ZED A;  5DLT A;  1O99 A;  3MK1 A;  4CXK A;  4QAX A;  1Y6V A;  1ED9 A;  1ALJ A;  1KH7 A;  2W5X A;  1HQA A;  3NVL A;  2GLQ A;  2W5T A;  3NKP A;  3UO0 A;  1N2L A;  3UN3 A;  1URB A;  1KHN A;  4LRD A;  1FSU A;  1ALK A;  4N7T A;  1E3C P;  2W5R A;  4LRE A;  4UOP A;  5EGE A;  5LQQ A;  1ANI A;  3UN2 A;  3T02 A;  4MIV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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