1P2II

Structural consequences of accommodation of four non-cognate amino-acid residues in the s1 pocket of bovine trypsin and chymotrypsin
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCGARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCLRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Bos taurus
molecule keywords Trypsinogen, cationic
total genus 10
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 2003-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1p2iI00
2DDJA 3BTEI 1IRHA 1LD6A 3BTTI 1TAWB 3UOUB 3BYBA 3FP6I 1TOCR 1QLQA 3WNYA 1BZXI 2DDIA 3TGII 1KIGI 3BTKI 2IJOI 1F7ZI 1ZJDB 3LDMA 1ZR0B 1ADZA 1CO7I 3BTGI 3FP7J 3TGJI 5JB4A 2ZVXA 4BNRI 1Y62A 2UUYB 5JB6A 1BPIA 1AALA 1T8NB 4NTWB 1P2JI 3P95E 1P2OB 3UIRC 2UUXA 3L33E 3AUDA 4Y0ZI 3BTFI 1BTIA 4PTIA 5PTIA 3L3TE 3TGKI 1EAWB 1D0DA 1YLCB 2TPII 1G6XA 1T8LB 4TPII 3T62D 3AUEA 3AUCA 3AUHA 3BTDI 1T8OB 3BTWI 1CBWD 4U32X 1CA0D 1JV9A 1T7CB 1BRBI 1OA65 1UUAA 3LDJA 1P2QB 3CI7A 2FTLI 4WXVC 5C67C 2FTMB 1BZ5A 4ISOB 2LFLA 1P2II 3AUBA 3BTQI 1KUNA 1JC6A 3OTJI 3U1JE 1MTND 2FI4I 3D65I 1FANA 2M99A 4U30W 3LDIA 3BTMI 2J6DA 4WWYC 1DENA 1BF0A 1SHPA 2KNTA 1UUBA 1K6UA 3AUIA 7PTIA 1LD5A 1KNTA 1EJMB 1F5RI 1BTHP 1OA55 2LFKA 3GYMI 4NTYB 3FP8I 2HEXA 4ISLB 1DEMA 3AUGA 8PTIA 4DTGK 4Y11I 1KTHA 1P2MB 1D0DB 3TPII 1YLDB 1P2NB 2W8XA 1BPTA 4NTXB 3P92E 3OFWA 1DTKA 1B0CA 1FAKI 6PTIA 1BHCA 1BRCI 2KCRA 2TGPI 1DTXA 2M01A 5JB5A 1AAPA 2PTCI 1JV8A 4BD9B 4BQDA 3BTHI 5JB7A 1YC0I 2R9PE 1TCPA 2ZJXA 2FI3I 4Y0YI 1TFXC 1NAGA 2ODYE 1TAPA 1PITA 2KAII 1BUNB 1FY8I 2JOTA 1TPAI 2FI5I 1P2KI 1YKTB 2CA7A 3M7QB 4DG4C 4ISNB 9PTIA 2RA3C 4Y10I 1BIKA 1T8MB
chains in the Genus database with same CATH superfamily
2DDJA 3BTEI 1IRHA 1LD6A 3BTTI 1TAWB 3UOUB 3BYBA 3FP6I 1TOCR 1QLQA 3WNYA 1BZXI 2DDIA 3TGII 1KIGI 3BTKI 2IJOI 1F7ZI 1ZJDB 3LDMA 1ZR0B 1ADZA 1CO7I 3BTGI 3FP7J 3TGJI 5JB4A 2ZVXA 4BNRI 1Y62A 2UUYB 5JB6A 1BPIA 1AALA 1T8NB 4NTWB 1P2JI 3P95E 1P2OB 3UIRC 2UUXA 3L33E 3AUDA 4Y0ZI 3BTFI 1BTIA 4PTIA 5PTIA 3L3TE 3TGKI 1EAWB 1D0DA 1YLCB 2TPII 1G6XA 1T8LB 4TPII 3T62D 3AUEA 3AUCA 3AUHA 3BTDI 1T8OB 3BTWI 1CBWD 4U32X 1CA0D 1JV9A 1T7CB 1BRBI 1OA65 1UUAA 3LDJA 1P2QB 3CI7A 2FTLI 4WXVC 5C67C 2FTMB 1BZ5A 4ISOB 2LFLA 1P2II 3AUBA 3BTQI 1KUNA 1JC6A 3OTJI 3U1JE 1MTND 2FI4I 3D65I 1FANA 2M99A 4U30W 3LDIA 3BTMI 2J6DA 4WWYC 1DENA 1BF0A 1SHPA 2KNTA 1UUBA 1K6UA 3AUIA 7PTIA 1LD5A 1KNTA 1EJMB 1F5RI 1BTHP 1OA55 2LFKA 3GYMI 4NTYB 3FP8I 2HEXA 4ISLB 1DEMA 3AUGA 8PTIA 4DTGK 4Y11I 1KTHA 1P2MB 1D0DB 3TPII 1YLDB 1P2NB 2W8XA 1BPTA 4NTXB 3P92E 3OFWA 1DTKA 1B0CA 1FAKI 6PTIA 1BHCA 1BRCI 2KCRA 2TGPI 1DTXA 2M01A 5JB5A 1AAPA 2PTCI 1JV8A 4BD9B 4BQDA 3BTHI 5JB7A 1YC0I 2R9PE 1TCPA 2ZJXA 2FI3I 4Y0YI 1TFXC 1NAGA 2ODYE 1TAPA 1PITA 2KAII 1BUNB 1FY8I 2JOTA 1TPAI 2FI5I 1P2KI 1YKTB 2CA7A 3M7QB 4DG4C 4ISNB 9PTIA 2RA3C 4Y10I 1BIKA 1T8MB
chains in the Genus database with same CATH topology
2DDJA 3BTEI 1IRHA 1LD6A 3BTTI 1TAWB 3UOUB 3BYBA 3FP6I 1TOCR 1QLQA 3WNYA 1BZXI 2DDIA 3TGII 1KIGI 3BTKI 2IJOI 1F7ZI 1ZJDB 3LDMA 1ZR0B 1ADZA 1CO7I 3BTGI 3FP7J 3TGJI 5JB4A 2ZVXA 4BNRI 1Y62A 2UUYB 5JB6A 1BPIA 1AALA 1T8NB 4NTWB 1P2JI 3P95E 1P2OB 3UIRC 2UUXA 3L33E 3AUDA 4Y0ZI 3BTFI 1BTIA 4PTIA 5PTIA 3L3TE 3TGKI 1EAWB 1D0DA 1YLCB 2TPII 1G6XA 1T8LB 4TPII 3T62D 3AUEA 3AUCA 3AUHA 3BTDI 1T8OB 3BTWI 1CBWD 4U32X 1CA0D 1JV9A 1T7CB 1BRBI 1OA65 1UUAA 3LDJA 1P2QB 3CI7A 2FTLI 4WXVC 5C67C 2FTMB 1BZ5A 4ISOB 2LFLA 1P2II 3AUBA 3BTQI 1KUNA 1JC6A 3OTJI 3U1JE 1MTND 2FI4I 3D65I 1FANA 2M99A 4U30W 3LDIA 3BTMI 2J6DA 4WWYC 1DENA 1BF0A 1SHPA 2KNTA 1UUBA 1K6UA 3AUIA 7PTIA 1LD5A 1KNTA 1EJMB 1F5RI 1BTHP 1OA55 2LFKA 3GYMI 4NTYB 3FP8I 2HEXA 4ISLB 1DEMA 3AUGA 8PTIA 4DTGK 4Y11I 1KTHA 1P2MB 1D0DB 3TPII 1YLDB 1P2NB 2W8XA 1BPTA 4NTXB 3P92E 3OFWA 1DTKA 1B0CA 1FAKI 6PTIA 1BHCA 1BRCI 2KCRA 2TGPI 1DTXA 2M01A 5JB5A 1AAPA 2PTCI 1JV8A 4BD9B 4BQDA 3BTHI 5JB7A 1YC0I 2R9PE 1TCPA 2ZJXA 2FI3I 4Y0YI 1TFXC 1NAGA 2ODYE 1TAPA 1PITA 2KAII 1BUNB 1FY8I 2JOTA 1TPAI 2FI5I 1P2KI 1YKTB 2CA7A 3M7QB 4DG4C 4ISNB 9PTIA 2RA3C 4Y10I 1BIKA 1T8MB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2DDJ A;  3BTE I;  1IRH A;  1LD6 A;  3BTT I;  1TAW B;  3UOU B;  3BYB A;  3FP6 I;  1TOC R;  1QLQ A;  3WNY A;  1BZX I;  2DDI A;  3TGI I;  1KIG I;  3BTK I;  2IJO I;  1F7Z I;  1ZJD B;  3LDM A;  1ZR0 B;  1ADZ A;  1CO7 I;  3BTG I;  3FP7 J;  3TGJ I;  5JB4 A;  2ZVX A;  4BNR I;  1Y62 A;  2UUY B;  5JB6 A;  1BPI A;  1AAL A;  1T8N B;  4NTW B;  1P2J I;  3P95 E;  1P2O B;  3UIR C;  2UUX A;  3L33 E;  3AUD A;  4Y0Z I;  3BTF I;  1BTI A;  4PTI A;  5PTI A;  3L3T E;  3TGK I;  1EAW B;  1D0D A;  1YLC B;  2TPI I;  1G6X A;  1T8L B;  4TPI I;  3T62 D;  3AUE A;  3AUC A;  3AUH A;  3BTD I;  1T8O B;  3BTW I;  1CBW D;  4U32 X;  1CA0 D;  1JV9 A;  1T7C B;  1BRB I;  1OA6 5;  1UUA A;  3LDJ A;  1P2Q B;  3CI7 A;  2FTL I;  4WXV C;  5C67 C;  2FTM B;  1BZ5 A;  4ISO B;  2LFL A;  1P2I I;  3AUB A;  3BTQ I;  1KUN A;  1JC6 A;  3OTJ I;  3U1J E;  1MTN D;  2FI4 I;  3D65 I;  1FAN A;  2M99 A;  4U30 W;  3LDI A;  3BTM I;  2J6D A;  4WWY C;  1DEN A;  1BF0 A;  1SHP A;  2KNT A;  1UUB A;  1K6U A;  3AUI A;  7PTI A;  1LD5 A;  1KNT A;  1EJM B;  1F5R I;  1BTH P;  1OA5 5;  2LFK A;  3GYM I;  4NTY B;  3FP8 I;  2HEX A;  4ISL B;  1DEM A;  3AUG A;  8PTI A;  4DTG K;  4Y11 I;  1KTH A;  1P2M B;  1D0D B;  3TPI I;  1YLD B;  1P2N B;  2W8X A;  1BPT A;  4NTX B;  3P92 E;  3OFW A;  1DTK A;  1B0C A;  1FAK I;  6PTI A;  1BHC A;  1BRC I;  2KCR A;  2TGP I;  1DTX A;  2M01 A;  5JB5 A;  1AAP A;  2PTC I;  1JV8 A;  4BD9 B;  4BQD A;  3BTH I;  5JB7 A;  1YC0 I;  2R9P E;  1TCP A;  2ZJX A;  2FI3 I;  4Y0Y I;  1TFX C;  1NAG A;  2ODY E;  1TAP A;  1PIT A;  2KAI I;  1BUN B;  1FY8 I;  2JOT A;  1TPA I;  2FI5 I;  1P2K I;  1YKT B;  2CA7 A;  3M7Q B;  4DG4 C;  4ISN B;  9PTI A;  2RA3 C;  4Y10 I;  1BIK A;  1T8M B; 
#chains in the Genus database with same CATH topology
 2DDJ A;  3BTE I;  1IRH A;  1LD6 A;  3BTT I;  1TAW B;  3UOU B;  3BYB A;  3FP6 I;  1TOC R;  1QLQ A;  3WNY A;  1BZX I;  2DDI A;  3TGI I;  1KIG I;  3BTK I;  2IJO I;  1F7Z I;  1ZJD B;  3LDM A;  1ZR0 B;  1ADZ A;  1CO7 I;  3BTG I;  3FP7 J;  3TGJ I;  5JB4 A;  2ZVX A;  4BNR I;  1Y62 A;  2UUY B;  5JB6 A;  1BPI A;  1AAL A;  1T8N B;  4NTW B;  1P2J I;  3P95 E;  1P2O B;  3UIR C;  2UUX A;  3L33 E;  3AUD A;  4Y0Z I;  3BTF I;  1BTI A;  4PTI A;  5PTI A;  3L3T E;  3TGK I;  1EAW B;  1D0D A;  1YLC B;  2TPI I;  1G6X A;  1T8L B;  4TPI I;  3T62 D;  3AUE A;  3AUC A;  3AUH A;  3BTD I;  1T8O B;  3BTW I;  1CBW D;  4U32 X;  1CA0 D;  1JV9 A;  1T7C B;  1BRB I;  1OA6 5;  1UUA A;  3LDJ A;  1P2Q B;  3CI7 A;  2FTL I;  4WXV C;  5C67 C;  2FTM B;  1BZ5 A;  4ISO B;  2LFL A;  1P2I I;  3AUB A;  3BTQ I;  1KUN A;  1JC6 A;  3OTJ I;  3U1J E;  1MTN D;  2FI4 I;  3D65 I;  1FAN A;  2M99 A;  4U30 W;  3LDI A;  3BTM I;  2J6D A;  4WWY C;  1DEN A;  1BF0 A;  1SHP A;  2KNT A;  1UUB A;  1K6U A;  3AUI A;  7PTI A;  1LD5 A;  1KNT A;  1EJM B;  1F5R I;  1BTH P;  1OA5 5;  2LFK A;  3GYM I;  4NTY B;  3FP8 I;  2HEX A;  4ISL B;  1DEM A;  3AUG A;  8PTI A;  4DTG K;  4Y11 I;  1KTH A;  1P2M B;  1D0D B;  3TPI I;  1YLD B;  1P2N B;  2W8X A;  1BPT A;  4NTX B;  3P92 E;  3OFW A;  1DTK A;  1B0C A;  1FAK I;  6PTI A;  1BHC A;  1BRC I;  2KCR A;  2TGP I;  1DTX A;  2M01 A;  5JB5 A;  1AAP A;  2PTC I;  1JV8 A;  4BD9 B;  4BQD A;  3BTH I;  5JB7 A;  1YC0 I;  2R9P E;  1TCP A;  2ZJX A;  2FI3 I;  4Y0Y I;  1TFX C;  1NAG A;  2ODY E;  1TAP A;  1PIT A;  2KAI I;  1BUN B;  1FY8 I;  2JOT A;  1TPA I;  2FI5 I;  1P2K I;  1YKT B;  2CA7 A;  3M7Q B;  4DG4 C;  4ISN B;  9PTI A;  2RA3 C;  4Y10 I;  1BIK A;  1T8M B; 
#chains in the Genus database with same CATH homology
 2DDJ A;  3BTE I;  1IRH A;  1LD6 A;  3BTT I;  1TAW B;  3UOU B;  3BYB A;  3FP6 I;  1TOC R;  1QLQ A;  3WNY A;  1BZX I;  2DDI A;  3TGI I;  1KIG I;  3BTK I;  2IJO I;  1F7Z I;  1ZJD B;  3LDM A;  1ZR0 B;  1ADZ A;  1CO7 I;  3BTG I;  3FP7 J;  3TGJ I;  5JB4 A;  2ZVX A;  4BNR I;  1Y62 A;  2UUY B;  5JB6 A;  1BPI A;  1AAL A;  1T8N B;  4NTW B;  1P2J I;  3P95 E;  1P2O B;  3UIR C;  2UUX A;  3L33 E;  3AUD A;  4Y0Z I;  3BTF I;  1BTI A;  4PTI A;  5PTI A;  3L3T E;  3TGK I;  1EAW B;  1D0D A;  1YLC B;  2TPI I;  1G6X A;  1T8L B;  4TPI I;  3T62 D;  3AUE A;  3AUC A;  3AUH A;  3BTD I;  1T8O B;  3BTW I;  1CBW D;  4U32 X;  1CA0 D;  1JV9 A;  1T7C B;  1BRB I;  1OA6 5;  1UUA A;  3LDJ A;  1P2Q B;  3CI7 A;  2FTL I;  4WXV C;  5C67 C;  2FTM B;  1BZ5 A;  4ISO B;  2LFL A;  1P2I I;  3AUB A;  3BTQ I;  1KUN A;  1JC6 A;  3OTJ I;  3U1J E;  1MTN D;  2FI4 I;  3D65 I;  1FAN A;  2M99 A;  4U30 W;  3LDI A;  3BTM I;  2J6D A;  4WWY C;  1DEN A;  1BF0 A;  1SHP A;  2KNT A;  1UUB A;  1K6U A;  3AUI A;  7PTI A;  1LD5 A;  1KNT A;  1EJM B;  1F5R I;  1BTH P;  1OA5 5;  2LFK A;  3GYM I;  4NTY B;  3FP8 I;  2HEX A;  4ISL B;  1DEM A;  3AUG A;  8PTI A;  4DTG K;  4Y11 I;  1KTH A;  1P2M B;  1D0D B;  3TPI I;  1YLD B;  1P2N B;  2W8X A;  1BPT A;  4NTX B;  3P92 E;  3OFW A;  1DTK A;  1B0C A;  1FAK I;  6PTI A;  1BHC A;  1BRC I;  2KCR A;  2TGP I;  1DTX A;  2M01 A;  5JB5 A;  1AAP A;  2PTC I;  1JV8 A;  4BD9 B;  4BQD A;  3BTH I;  5JB7 A;  1YC0 I;  2R9P E;  1TCP A;  2ZJX A;  2FI3 I;  4Y0Y I;  1TFX C;  1NAG A;  2ODY E;  1TAP A;  1PIT A;  2KAI I;  1BUN B;  1FY8 I;  2JOT A;  1TPA I;  2FI5 I;  1P2K I;  1YKT B;  2CA7 A;  3M7Q B;  4DG4 C;  4ISN B;  9PTI A;  2RA3 C;  4Y10 I;  1BIK A;  1T8M B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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