1P2MB

Structural consequences of accommodation of four non-cognate amino-acid residues in the s1 pocket of bovine trypsin and chymotrypsin
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCGARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCLRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Bos taurus
molecule keywords Chymotrypsinogen A
total genus 11
structure length 58
sequence length 58
chains with identical sequence D
ec nomenclature
pdb deposition date 2003-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1p2mB00
4BD9B 1BPTA 1KUNA 1TAPA 3BTTI 8PTIA 2FI4I 4NTWB 1SHPA 2ZJXA 3OFWA 3LDIA 1D0DB 2FTMB 3UOUB 4WXVC 4ISOB 1BZ5A 1LD6A 1BHCA 1OA55 1ZJDB 1CA0D 3T62D 2HEXA 1BRCI 3OTJI 5JB4A 2J6DA 1TFXC 3BTQI 2IJOI 5JB5A 1ZR0B 1ADZA 3BTFI 2RA3C 3L3TE 5JB6A 1CBWD 1DTXA 1T7CB 4DTGK 1P2MB 3LDMA 3TGII 4Y0YI 3BYBA 4U30W 1UUAA 1FANA 1NAGA 1YC0I 4Y10I 1TCPA 1BPIA 2FTLI 2M01A 1P2JI 1YLDB 1OA65 2DDIA 3D65I 3TGJI 2ZVXA 3AUBA 3GYMI 3U1JE 7PTIA 4Y0ZI 4Y11I 4DG4C 1DEMA 1TOCR 2CA7A 3BTWI 3BTGI 1BF0A 1EAWB 3BTHI 2UUYB 3AUEA 1F7ZI 1P2KI 2LFKA 5C67C 1PITA 1JV9A 2KCRA 3AUCA 2M99A 2PTCI 3UIRC 4ISNB 1YKTB 4TPII 2FI3I 3P92E 1JV8A 1F5RI 1AAPA 9PTIA 1G6XA 1BZXI 1T8LB 3M7QB 1BRBI 2KAII 1BIKA 1LD5A 1AALA 3L33E 4BNRI 2KNTA 3TGKI 1D0DA 2UUXA 1JC6A 3FP6I 1IRHA 2W8XA 1KTHA 1P2QB 4NTXB 1FY8I 5PTIA 1MTND 2ODYE 1CO7I 1TPAI 1P2NB 3P95E 3LDJA 4WWYC 1DTKA 3CI7A 1FAKI 4NTYB 6PTIA 2R9PE 1T8OB 3BTMI 1P2II 1TAWB 1BTIA 2LFLA 3AUDA 1Y62A 4PTIA 3BTDI 1K6UA 4BQDA 1T8NB 1YLCB 5JB7A 1P2OB 2DDJA 1T8MB 2FI5I 3BTEI 1KIGI 4U32X 4ISLB 3WNYA 1BTHP 1DENA 1QLQA 2JOTA 1BUNB 3AUHA 3BTKI 1B0CA 3FP7J 3FP8I 3TPII 2TGPI 3AUIA 3AUGA 2TPII 1KNTA 1EJMB 1UUBA
chains in the Genus database with same CATH superfamily
4BD9B 1BPTA 1KUNA 1TAPA 3BTTI 8PTIA 2FI4I 4NTWB 1SHPA 2ZJXA 3OFWA 3LDIA 1D0DB 2FTMB 3UOUB 4WXVC 4ISOB 1BZ5A 1LD6A 1BHCA 1OA55 1ZJDB 1CA0D 3T62D 2HEXA 1BRCI 3OTJI 5JB4A 2J6DA 1TFXC 3BTQI 2IJOI 5JB5A 1ZR0B 1ADZA 3BTFI 2RA3C 3L3TE 5JB6A 1CBWD 1DTXA 1T7CB 4DTGK 1P2MB 3LDMA 3TGII 4Y0YI 3BYBA 4U30W 1UUAA 1FANA 1NAGA 1YC0I 4Y10I 1TCPA 1BPIA 2FTLI 2M01A 1P2JI 1YLDB 1OA65 2DDIA 3D65I 3TGJI 2ZVXA 3AUBA 3GYMI 3U1JE 7PTIA 4Y0ZI 4Y11I 4DG4C 1DEMA 1TOCR 2CA7A 3BTWI 3BTGI 1BF0A 1EAWB 3BTHI 2UUYB 3AUEA 1F7ZI 1P2KI 2LFKA 5C67C 1PITA 1JV9A 2KCRA 3AUCA 2M99A 2PTCI 3UIRC 4ISNB 1YKTB 4TPII 2FI3I 3P92E 1JV8A 1F5RI 1AAPA 9PTIA 1G6XA 1BZXI 1T8LB 3M7QB 1BRBI 2KAII 1BIKA 1LD5A 1AALA 3L33E 4BNRI 2KNTA 3TGKI 1D0DA 2UUXA 1JC6A 3FP6I 1IRHA 2W8XA 1KTHA 1P2QB 4NTXB 1FY8I 5PTIA 1MTND 2ODYE 1CO7I 1TPAI 1P2NB 3P95E 3LDJA 4WWYC 1DTKA 3CI7A 1FAKI 4NTYB 6PTIA 2R9PE 1T8OB 3BTMI 1P2II 1TAWB 1BTIA 2LFLA 3AUDA 1Y62A 4PTIA 3BTDI 1K6UA 4BQDA 1T8NB 1YLCB 5JB7A 1P2OB 2DDJA 1T8MB 2FI5I 3BTEI 1KIGI 4U32X 4ISLB 3WNYA 1BTHP 1DENA 1QLQA 2JOTA 1BUNB 3AUHA 3BTKI 1B0CA 3FP7J 3FP8I 3TPII 2TGPI 3AUIA 3AUGA 2TPII 1KNTA 1EJMB 1UUBA
chains in the Genus database with same CATH topology
4BD9B 1BPTA 1KUNA 1TAPA 3BTTI 8PTIA 2FI4I 4NTWB 1SHPA 2ZJXA 3OFWA 3LDIA 1D0DB 2FTMB 3UOUB 4WXVC 4ISOB 1BZ5A 1LD6A 1BHCA 1OA55 1ZJDB 1CA0D 3T62D 2HEXA 1BRCI 3OTJI 5JB4A 2J6DA 1TFXC 3BTQI 2IJOI 5JB5A 1ZR0B 1ADZA 3BTFI 2RA3C 3L3TE 5JB6A 1CBWD 1DTXA 1T7CB 4DTGK 1P2MB 3LDMA 3TGII 4Y0YI 3BYBA 4U30W 1UUAA 1FANA 1NAGA 1YC0I 4Y10I 1TCPA 1BPIA 2FTLI 2M01A 1P2JI 1YLDB 1OA65 2DDIA 3D65I 3TGJI 2ZVXA 3AUBA 3GYMI 3U1JE 7PTIA 4Y0ZI 4Y11I 4DG4C 1DEMA 1TOCR 2CA7A 3BTWI 3BTGI 1BF0A 1EAWB 3BTHI 2UUYB 3AUEA 1F7ZI 1P2KI 2LFKA 5C67C 1PITA 1JV9A 2KCRA 3AUCA 2M99A 2PTCI 3UIRC 4ISNB 1YKTB 4TPII 2FI3I 3P92E 1JV8A 1F5RI 1AAPA 9PTIA 1G6XA 1BZXI 1T8LB 3M7QB 1BRBI 2KAII 1BIKA 1LD5A 1AALA 3L33E 4BNRI 2KNTA 3TGKI 1D0DA 2UUXA 1JC6A 3FP6I 1IRHA 2W8XA 1KTHA 1P2QB 4NTXB 1FY8I 5PTIA 1MTND 2ODYE 1CO7I 1TPAI 1P2NB 3P95E 3LDJA 4WWYC 1DTKA 3CI7A 1FAKI 4NTYB 6PTIA 2R9PE 1T8OB 3BTMI 1P2II 1TAWB 1BTIA 2LFLA 3AUDA 1Y62A 4PTIA 3BTDI 1K6UA 4BQDA 1T8NB 1YLCB 5JB7A 1P2OB 2DDJA 1T8MB 2FI5I 3BTEI 1KIGI 4U32X 4ISLB 3WNYA 1BTHP 1DENA 1QLQA 2JOTA 1BUNB 3AUHA 3BTKI 1B0CA 3FP7J 3FP8I 3TPII 2TGPI 3AUIA 3AUGA 2TPII 1KNTA 1EJMB 1UUBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BD9 B;  1BPT A;  1KUN A;  1TAP A;  3BTT I;  8PTI A;  2FI4 I;  4NTW B;  1SHP A;  2ZJX A;  3OFW A;  3LDI A;  1D0D B;  2FTM B;  3UOU B;  4WXV C;  4ISO B;  1BZ5 A;  1LD6 A;  1BHC A;  1OA5 5;  1ZJD B;  1CA0 D;  3T62 D;  2HEX A;  1BRC I;  3OTJ I;  5JB4 A;  2J6D A;  1TFX C;  3BTQ I;  2IJO I;  5JB5 A;  1ZR0 B;  1ADZ A;  3BTF I;  2RA3 C;  3L3T E;  5JB6 A;  1CBW D;  1DTX A;  1T7C B;  4DTG K;  1P2M B;  3LDM A;  3TGI I;  4Y0Y I;  3BYB A;  4U30 W;  1UUA A;  1FAN A;  1NAG A;  1YC0 I;  4Y10 I;  1TCP A;  1BPI A;  2FTL I;  2M01 A;  1P2J I;  1YLD B;  1OA6 5;  2DDI A;  3D65 I;  3TGJ I;  2ZVX A;  3AUB A;  3GYM I;  3U1J E;  7PTI A;  4Y0Z I;  4Y11 I;  4DG4 C;  1DEM A;  1TOC R;  2CA7 A;  3BTW I;  3BTG I;  1BF0 A;  1EAW B;  3BTH I;  2UUY B;  3AUE A;  1F7Z I;  1P2K I;  2LFK A;  5C67 C;  1PIT A;  1JV9 A;  2KCR A;  3AUC A;  2M99 A;  2PTC I;  3UIR C;  4ISN B;  1YKT B;  4TPI I;  2FI3 I;  3P92 E;  1JV8 A;  1F5R I;  1AAP A;  9PTI A;  1G6X A;  1BZX I;  1T8L B;  3M7Q B;  1BRB I;  2KAI I;  1BIK A;  1LD5 A;  1AAL A;  3L33 E;  4BNR I;  2KNT A;  3TGK I;  1D0D A;  2UUX A;  1JC6 A;  3FP6 I;  1IRH A;  2W8X A;  1KTH A;  1P2Q B;  4NTX B;  1FY8 I;  5PTI A;  1MTN D;  2ODY E;  1CO7 I;  1TPA I;  1P2N B;  3P95 E;  3LDJ A;  4WWY C;  1DTK A;  3CI7 A;  1FAK I;  4NTY B;  6PTI A;  2R9P E;  1T8O B;  3BTM I;  1P2I I;  1TAW B;  1BTI A;  2LFL A;  3AUD A;  1Y62 A;  4PTI A;  3BTD I;  1K6U A;  4BQD A;  1T8N B;  1YLC B;  5JB7 A;  1P2O B;  2DDJ A;  1T8M B;  2FI5 I;  3BTE I;  1KIG I;  4U32 X;  4ISL B;  3WNY A;  1BTH P;  1DEN A;  1QLQ A;  2JOT A;  1BUN B;  3AUH A;  3BTK I;  1B0C A;  3FP7 J;  3FP8 I;  3TPI I;  2TGP I;  3AUI A;  3AUG A;  2TPI I;  1KNT A;  1EJM B;  1UUB A; 
#chains in the Genus database with same CATH topology
 4BD9 B;  1BPT A;  1KUN A;  1TAP A;  3BTT I;  8PTI A;  2FI4 I;  4NTW B;  1SHP A;  2ZJX A;  3OFW A;  3LDI A;  1D0D B;  2FTM B;  3UOU B;  4WXV C;  4ISO B;  1BZ5 A;  1LD6 A;  1BHC A;  1OA5 5;  1ZJD B;  1CA0 D;  3T62 D;  2HEX A;  1BRC I;  3OTJ I;  5JB4 A;  2J6D A;  1TFX C;  3BTQ I;  2IJO I;  5JB5 A;  1ZR0 B;  1ADZ A;  3BTF I;  2RA3 C;  3L3T E;  5JB6 A;  1CBW D;  1DTX A;  1T7C B;  4DTG K;  1P2M B;  3LDM A;  3TGI I;  4Y0Y I;  3BYB A;  4U30 W;  1UUA A;  1FAN A;  1NAG A;  1YC0 I;  4Y10 I;  1TCP A;  1BPI A;  2FTL I;  2M01 A;  1P2J I;  1YLD B;  1OA6 5;  2DDI A;  3D65 I;  3TGJ I;  2ZVX A;  3AUB A;  3GYM I;  3U1J E;  7PTI A;  4Y0Z I;  4Y11 I;  4DG4 C;  1DEM A;  1TOC R;  2CA7 A;  3BTW I;  3BTG I;  1BF0 A;  1EAW B;  3BTH I;  2UUY B;  3AUE A;  1F7Z I;  1P2K I;  2LFK A;  5C67 C;  1PIT A;  1JV9 A;  2KCR A;  3AUC A;  2M99 A;  2PTC I;  3UIR C;  4ISN B;  1YKT B;  4TPI I;  2FI3 I;  3P92 E;  1JV8 A;  1F5R I;  1AAP A;  9PTI A;  1G6X A;  1BZX I;  1T8L B;  3M7Q B;  1BRB I;  2KAI I;  1BIK A;  1LD5 A;  1AAL A;  3L33 E;  4BNR I;  2KNT A;  3TGK I;  1D0D A;  2UUX A;  1JC6 A;  3FP6 I;  1IRH A;  2W8X A;  1KTH A;  1P2Q B;  4NTX B;  1FY8 I;  5PTI A;  1MTN D;  2ODY E;  1CO7 I;  1TPA I;  1P2N B;  3P95 E;  3LDJ A;  4WWY C;  1DTK A;  3CI7 A;  1FAK I;  4NTY B;  6PTI A;  2R9P E;  1T8O B;  3BTM I;  1P2I I;  1TAW B;  1BTI A;  2LFL A;  3AUD A;  1Y62 A;  4PTI A;  3BTD I;  1K6U A;  4BQD A;  1T8N B;  1YLC B;  5JB7 A;  1P2O B;  2DDJ A;  1T8M B;  2FI5 I;  3BTE I;  1KIG I;  4U32 X;  4ISL B;  3WNY A;  1BTH P;  1DEN A;  1QLQ A;  2JOT A;  1BUN B;  3AUH A;  3BTK I;  1B0C A;  3FP7 J;  3FP8 I;  3TPI I;  2TGP I;  3AUI A;  3AUG A;  2TPI I;  1KNT A;  1EJM B;  1UUB A; 
#chains in the Genus database with same CATH homology
 4BD9 B;  1BPT A;  1KUN A;  1TAP A;  3BTT I;  8PTI A;  2FI4 I;  4NTW B;  1SHP A;  2ZJX A;  3OFW A;  3LDI A;  1D0D B;  2FTM B;  3UOU B;  4WXV C;  4ISO B;  1BZ5 A;  1LD6 A;  1BHC A;  1OA5 5;  1ZJD B;  1CA0 D;  3T62 D;  2HEX A;  1BRC I;  3OTJ I;  5JB4 A;  2J6D A;  1TFX C;  3BTQ I;  2IJO I;  5JB5 A;  1ZR0 B;  1ADZ A;  3BTF I;  2RA3 C;  3L3T E;  5JB6 A;  1CBW D;  1DTX A;  1T7C B;  4DTG K;  1P2M B;  3LDM A;  3TGI I;  4Y0Y I;  3BYB A;  4U30 W;  1UUA A;  1FAN A;  1NAG A;  1YC0 I;  4Y10 I;  1TCP A;  1BPI A;  2FTL I;  2M01 A;  1P2J I;  1YLD B;  1OA6 5;  2DDI A;  3D65 I;  3TGJ I;  2ZVX A;  3AUB A;  3GYM I;  3U1J E;  7PTI A;  4Y0Z I;  4Y11 I;  4DG4 C;  1DEM A;  1TOC R;  2CA7 A;  3BTW I;  3BTG I;  1BF0 A;  1EAW B;  3BTH I;  2UUY B;  3AUE A;  1F7Z I;  1P2K I;  2LFK A;  5C67 C;  1PIT A;  1JV9 A;  2KCR A;  3AUC A;  2M99 A;  2PTC I;  3UIR C;  4ISN B;  1YKT B;  4TPI I;  2FI3 I;  3P92 E;  1JV8 A;  1F5R I;  1AAP A;  9PTI A;  1G6X A;  1BZX I;  1T8L B;  3M7Q B;  1BRB I;  2KAI I;  1BIK A;  1LD5 A;  1AAL A;  3L33 E;  4BNR I;  2KNT A;  3TGK I;  1D0D A;  2UUX A;  1JC6 A;  3FP6 I;  1IRH A;  2W8X A;  1KTH A;  1P2Q B;  4NTX B;  1FY8 I;  5PTI A;  1MTN D;  2ODY E;  1CO7 I;  1TPA I;  1P2N B;  3P95 E;  3LDJ A;  4WWY C;  1DTK A;  3CI7 A;  1FAK I;  4NTY B;  6PTI A;  2R9P E;  1T8O B;  3BTM I;  1P2I I;  1TAW B;  1BTI A;  2LFL A;  3AUD A;  1Y62 A;  4PTI A;  3BTD I;  1K6U A;  4BQD A;  1T8N B;  1YLC B;  5JB7 A;  1P2O B;  2DDJ A;  1T8M B;  2FI5 I;  3BTE I;  1KIG I;  4U32 X;  4ISL B;  3WNY A;  1BTH P;  1DEN A;  1QLQ A;  2JOT A;  1BUN B;  3AUH A;  3BTK I;  1B0C A;  3FP7 J;  3FP8 I;  3TPI I;  2TGP I;  3AUI A;  3AUG A;  2TPI I;  1KNT A;  1EJM B;  1UUB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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