1P2NB

Structural consequences of accommodation of four non-cognate amino-acid residues in the s1 pocket of bovine trypsin and chymotrypsin
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCLARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCLRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Bos taurus
molecule keywords Chymotrypsinogen A
total genus 11
structure length 58
sequence length 58
chains with identical sequence D
ec nomenclature
pdb deposition date 2003-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1p2nB00
1YLCB 1BRCI 1F5RI 3OFWA 1DTKA 1FY8I 1TCPA 4Y0ZI 3AUDA 4Y10I 4NTYB 4U32X 1KUNA 1YLDB 1CBWD 2FI4I 1P2QB 1G6XA 2ODYE 1P2OB 4ISOB 1P2KI 4U30W 2KCRA 4Y0YI 2ZJXA 1IRHA 3OTJI 3AUBA 1BF0A 3FP6I 1TAWB 2DDJA 3L3TE 2RA3C 2UUYB 2JOTA 3UOUB 1PITA 1JV9A 3AUCA 5PTIA 1BZXI 1LD5A 1OA65 3AUHA 3BTWI 2M01A 4TPII 3LDMA 3P95E 3WNYA 1T7CB 3BTGI 2W8XA 4WWYC 1P2NB 3FP8I 1TOCR 2TGPI 1T8NB 4Y11I 3TGJI 1FANA 1AAPA 1EJMB 1KTHA 4BQDA 3BTTI 1TPAI 5JB6A 1EAWB 5JB4A 2R9PE 1T8LB 1Y62A 2FI3I 3BTQI 6PTIA 1NAGA 2CA7A 3AUIA 1T8MB 2LFKA 3CI7A 5JB5A 1DTXA 1K6UA 1DENA 4BNRI 3LDIA 1P2JI 4NTXB 3TGKI 1ZJDB 1BZ5A 3U1JE 1D0DB 1TAPA 1LD6A 2PTCI 1YC0I 2TPII 1QLQA 1CA0D 1KNTA 1SHPA 3TPII 3UIRC 4BD9B 1BIKA 1YKTB 1P2II 1ADZA 1D0DA 1P2MB 2FTLI 1BTIA 2DDIA 2KNTA 3T62D 3D65I 4DTGK 1OA55 4NTWB 2FTMB 1UUBA 3BTMI 3AUGA 1UUAA 2LFLA 3LDJA 1JC6A 1JV8A 9PTIA 2IJOI 3TGII 1MTND 3BTEI 3BTHI 1BPTA 5JB7A 4ISLB 3BTFI 1BTHP 1B0CA 1KIGI 1BRBI 1TFXC 2KAII 2J6DA 2UUXA 1F7ZI 2M99A 4ISNB 4DG4C 1T8OB 7PTIA 1AALA 3AUEA 3GYMI 3M7QB 2HEXA 4WXVC 8PTIA 3BTKI 1CO7I 1DEMA 3BYBA 1FAKI 3BTDI 4PTIA 1ZR0B 2FI5I 1BHCA 5C67C 2ZVXA 3FP7J 1BUNB 3P92E 3L33E 1BPIA
chains in the Genus database with same CATH superfamily
1YLCB 1BRCI 1F5RI 3OFWA 1DTKA 1FY8I 1TCPA 4Y0ZI 3AUDA 4Y10I 4NTYB 4U32X 1KUNA 1YLDB 1CBWD 2FI4I 1P2QB 1G6XA 2ODYE 1P2OB 4ISOB 1P2KI 4U30W 2KCRA 4Y0YI 2ZJXA 1IRHA 3OTJI 3AUBA 1BF0A 3FP6I 1TAWB 2DDJA 3L3TE 2RA3C 2UUYB 2JOTA 3UOUB 1PITA 1JV9A 3AUCA 5PTIA 1BZXI 1LD5A 1OA65 3AUHA 3BTWI 2M01A 4TPII 3LDMA 3P95E 3WNYA 1T7CB 3BTGI 2W8XA 4WWYC 1P2NB 3FP8I 1TOCR 2TGPI 1T8NB 4Y11I 3TGJI 1FANA 1AAPA 1EJMB 1KTHA 4BQDA 3BTTI 1TPAI 5JB6A 1EAWB 5JB4A 2R9PE 1T8LB 1Y62A 2FI3I 3BTQI 6PTIA 1NAGA 2CA7A 3AUIA 1T8MB 2LFKA 3CI7A 5JB5A 1DTXA 1K6UA 1DENA 4BNRI 3LDIA 1P2JI 4NTXB 3TGKI 1ZJDB 1BZ5A 3U1JE 1D0DB 1TAPA 1LD6A 2PTCI 1YC0I 2TPII 1QLQA 1CA0D 1KNTA 1SHPA 3TPII 3UIRC 4BD9B 1BIKA 1YKTB 1P2II 1ADZA 1D0DA 1P2MB 2FTLI 1BTIA 2DDIA 2KNTA 3T62D 3D65I 4DTGK 1OA55 4NTWB 2FTMB 1UUBA 3BTMI 3AUGA 1UUAA 2LFLA 3LDJA 1JC6A 1JV8A 9PTIA 2IJOI 3TGII 1MTND 3BTEI 3BTHI 1BPTA 5JB7A 4ISLB 3BTFI 1BTHP 1B0CA 1KIGI 1BRBI 1TFXC 2KAII 2J6DA 2UUXA 1F7ZI 2M99A 4ISNB 4DG4C 1T8OB 7PTIA 1AALA 3AUEA 3GYMI 3M7QB 2HEXA 4WXVC 8PTIA 3BTKI 1CO7I 1DEMA 3BYBA 1FAKI 3BTDI 4PTIA 1ZR0B 2FI5I 1BHCA 5C67C 2ZVXA 3FP7J 1BUNB 3P92E 3L33E 1BPIA
chains in the Genus database with same CATH topology
1YLCB 1BRCI 1F5RI 3OFWA 1DTKA 1FY8I 1TCPA 4Y0ZI 3AUDA 4Y10I 4NTYB 4U32X 1KUNA 1YLDB 1CBWD 2FI4I 1P2QB 1G6XA 2ODYE 1P2OB 4ISOB 1P2KI 4U30W 2KCRA 4Y0YI 2ZJXA 1IRHA 3OTJI 3AUBA 1BF0A 3FP6I 1TAWB 2DDJA 3L3TE 2RA3C 2UUYB 2JOTA 3UOUB 1PITA 1JV9A 3AUCA 5PTIA 1BZXI 1LD5A 1OA65 3AUHA 3BTWI 2M01A 4TPII 3LDMA 3P95E 3WNYA 1T7CB 3BTGI 2W8XA 4WWYC 1P2NB 3FP8I 1TOCR 2TGPI 1T8NB 4Y11I 3TGJI 1FANA 1AAPA 1EJMB 1KTHA 4BQDA 3BTTI 1TPAI 5JB6A 1EAWB 5JB4A 2R9PE 1T8LB 1Y62A 2FI3I 3BTQI 6PTIA 1NAGA 2CA7A 3AUIA 1T8MB 2LFKA 3CI7A 5JB5A 1DTXA 1K6UA 1DENA 4BNRI 3LDIA 1P2JI 4NTXB 3TGKI 1ZJDB 1BZ5A 3U1JE 1D0DB 1TAPA 1LD6A 2PTCI 1YC0I 2TPII 1QLQA 1CA0D 1KNTA 1SHPA 3TPII 3UIRC 4BD9B 1BIKA 1YKTB 1P2II 1ADZA 1D0DA 1P2MB 2FTLI 1BTIA 2DDIA 2KNTA 3T62D 3D65I 4DTGK 1OA55 4NTWB 2FTMB 1UUBA 3BTMI 3AUGA 1UUAA 2LFLA 3LDJA 1JC6A 1JV8A 9PTIA 2IJOI 3TGII 1MTND 3BTEI 3BTHI 1BPTA 5JB7A 4ISLB 3BTFI 1BTHP 1B0CA 1KIGI 1BRBI 1TFXC 2KAII 2J6DA 2UUXA 1F7ZI 2M99A 4ISNB 4DG4C 1T8OB 7PTIA 1AALA 3AUEA 3GYMI 3M7QB 2HEXA 4WXVC 8PTIA 3BTKI 1CO7I 1DEMA 3BYBA 1FAKI 3BTDI 4PTIA 1ZR0B 2FI5I 1BHCA 5C67C 2ZVXA 3FP7J 1BUNB 3P92E 3L33E 1BPIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YLC B;  1BRC I;  1F5R I;  3OFW A;  1DTK A;  1FY8 I;  1TCP A;  4Y0Z I;  3AUD A;  4Y10 I;  4NTY B;  4U32 X;  1KUN A;  1YLD B;  1CBW D;  2FI4 I;  1P2Q B;  1G6X A;  2ODY E;  1P2O B;  4ISO B;  1P2K I;  4U30 W;  2KCR A;  4Y0Y I;  2ZJX A;  1IRH A;  3OTJ I;  3AUB A;  1BF0 A;  3FP6 I;  1TAW B;  2DDJ A;  3L3T E;  2RA3 C;  2UUY B;  2JOT A;  3UOU B;  1PIT A;  1JV9 A;  3AUC A;  5PTI A;  1BZX I;  1LD5 A;  1OA6 5;  3AUH A;  3BTW I;  2M01 A;  4TPI I;  3LDM A;  3P95 E;  3WNY A;  1T7C B;  3BTG I;  2W8X A;  4WWY C;  1P2N B;  3FP8 I;  1TOC R;  2TGP I;  1T8N B;  4Y11 I;  3TGJ I;  1FAN A;  1AAP A;  1EJM B;  1KTH A;  4BQD A;  3BTT I;  1TPA I;  5JB6 A;  1EAW B;  5JB4 A;  2R9P E;  1T8L B;  1Y62 A;  2FI3 I;  3BTQ I;  6PTI A;  1NAG A;  2CA7 A;  3AUI A;  1T8M B;  2LFK A;  3CI7 A;  5JB5 A;  1DTX A;  1K6U A;  1DEN A;  4BNR I;  3LDI A;  1P2J I;  4NTX B;  3TGK I;  1ZJD B;  1BZ5 A;  3U1J E;  1D0D B;  1TAP A;  1LD6 A;  2PTC I;  1YC0 I;  2TPI I;  1QLQ A;  1CA0 D;  1KNT A;  1SHP A;  3TPI I;  3UIR C;  4BD9 B;  1BIK A;  1YKT B;  1P2I I;  1ADZ A;  1D0D A;  1P2M B;  2FTL I;  1BTI A;  2DDI A;  2KNT A;  3T62 D;  3D65 I;  4DTG K;  1OA5 5;  4NTW B;  2FTM B;  1UUB A;  3BTM I;  3AUG A;  1UUA A;  2LFL A;  3LDJ A;  1JC6 A;  1JV8 A;  9PTI A;  2IJO I;  3TGI I;  1MTN D;  3BTE I;  3BTH I;  1BPT A;  5JB7 A;  4ISL B;  3BTF I;  1BTH P;  1B0C A;  1KIG I;  1BRB I;  1TFX C;  2KAI I;  2J6D A;  2UUX A;  1F7Z I;  2M99 A;  4ISN B;  4DG4 C;  1T8O B;  7PTI A;  1AAL A;  3AUE A;  3GYM I;  3M7Q B;  2HEX A;  4WXV C;  8PTI A;  3BTK I;  1CO7 I;  1DEM A;  3BYB A;  1FAK I;  3BTD I;  4PTI A;  1ZR0 B;  2FI5 I;  1BHC A;  5C67 C;  2ZVX A;  3FP7 J;  1BUN B;  3P92 E;  3L33 E;  1BPI A; 
#chains in the Genus database with same CATH topology
 1YLC B;  1BRC I;  1F5R I;  3OFW A;  1DTK A;  1FY8 I;  1TCP A;  4Y0Z I;  3AUD A;  4Y10 I;  4NTY B;  4U32 X;  1KUN A;  1YLD B;  1CBW D;  2FI4 I;  1P2Q B;  1G6X A;  2ODY E;  1P2O B;  4ISO B;  1P2K I;  4U30 W;  2KCR A;  4Y0Y I;  2ZJX A;  1IRH A;  3OTJ I;  3AUB A;  1BF0 A;  3FP6 I;  1TAW B;  2DDJ A;  3L3T E;  2RA3 C;  2UUY B;  2JOT A;  3UOU B;  1PIT A;  1JV9 A;  3AUC A;  5PTI A;  1BZX I;  1LD5 A;  1OA6 5;  3AUH A;  3BTW I;  2M01 A;  4TPI I;  3LDM A;  3P95 E;  3WNY A;  1T7C B;  3BTG I;  2W8X A;  4WWY C;  1P2N B;  3FP8 I;  1TOC R;  2TGP I;  1T8N B;  4Y11 I;  3TGJ I;  1FAN A;  1AAP A;  1EJM B;  1KTH A;  4BQD A;  3BTT I;  1TPA I;  5JB6 A;  1EAW B;  5JB4 A;  2R9P E;  1T8L B;  1Y62 A;  2FI3 I;  3BTQ I;  6PTI A;  1NAG A;  2CA7 A;  3AUI A;  1T8M B;  2LFK A;  3CI7 A;  5JB5 A;  1DTX A;  1K6U A;  1DEN A;  4BNR I;  3LDI A;  1P2J I;  4NTX B;  3TGK I;  1ZJD B;  1BZ5 A;  3U1J E;  1D0D B;  1TAP A;  1LD6 A;  2PTC I;  1YC0 I;  2TPI I;  1QLQ A;  1CA0 D;  1KNT A;  1SHP A;  3TPI I;  3UIR C;  4BD9 B;  1BIK A;  1YKT B;  1P2I I;  1ADZ A;  1D0D A;  1P2M B;  2FTL I;  1BTI A;  2DDI A;  2KNT A;  3T62 D;  3D65 I;  4DTG K;  1OA5 5;  4NTW B;  2FTM B;  1UUB A;  3BTM I;  3AUG A;  1UUA A;  2LFL A;  3LDJ A;  1JC6 A;  1JV8 A;  9PTI A;  2IJO I;  3TGI I;  1MTN D;  3BTE I;  3BTH I;  1BPT A;  5JB7 A;  4ISL B;  3BTF I;  1BTH P;  1B0C A;  1KIG I;  1BRB I;  1TFX C;  2KAI I;  2J6D A;  2UUX A;  1F7Z I;  2M99 A;  4ISN B;  4DG4 C;  1T8O B;  7PTI A;  1AAL A;  3AUE A;  3GYM I;  3M7Q B;  2HEX A;  4WXV C;  8PTI A;  3BTK I;  1CO7 I;  1DEM A;  3BYB A;  1FAK I;  3BTD I;  4PTI A;  1ZR0 B;  2FI5 I;  1BHC A;  5C67 C;  2ZVX A;  3FP7 J;  1BUN B;  3P92 E;  3L33 E;  1BPI A; 
#chains in the Genus database with same CATH homology
 1YLC B;  1BRC I;  1F5R I;  3OFW A;  1DTK A;  1FY8 I;  1TCP A;  4Y0Z I;  3AUD A;  4Y10 I;  4NTY B;  4U32 X;  1KUN A;  1YLD B;  1CBW D;  2FI4 I;  1P2Q B;  1G6X A;  2ODY E;  1P2O B;  4ISO B;  1P2K I;  4U30 W;  2KCR A;  4Y0Y I;  2ZJX A;  1IRH A;  3OTJ I;  3AUB A;  1BF0 A;  3FP6 I;  1TAW B;  2DDJ A;  3L3T E;  2RA3 C;  2UUY B;  2JOT A;  3UOU B;  1PIT A;  1JV9 A;  3AUC A;  5PTI A;  1BZX I;  1LD5 A;  1OA6 5;  3AUH A;  3BTW I;  2M01 A;  4TPI I;  3LDM A;  3P95 E;  3WNY A;  1T7C B;  3BTG I;  2W8X A;  4WWY C;  1P2N B;  3FP8 I;  1TOC R;  2TGP I;  1T8N B;  4Y11 I;  3TGJ I;  1FAN A;  1AAP A;  1EJM B;  1KTH A;  4BQD A;  3BTT I;  1TPA I;  5JB6 A;  1EAW B;  5JB4 A;  2R9P E;  1T8L B;  1Y62 A;  2FI3 I;  3BTQ I;  6PTI A;  1NAG A;  2CA7 A;  3AUI A;  1T8M B;  2LFK A;  3CI7 A;  5JB5 A;  1DTX A;  1K6U A;  1DEN A;  4BNR I;  3LDI A;  1P2J I;  4NTX B;  3TGK I;  1ZJD B;  1BZ5 A;  3U1J E;  1D0D B;  1TAP A;  1LD6 A;  2PTC I;  1YC0 I;  2TPI I;  1QLQ A;  1CA0 D;  1KNT A;  1SHP A;  3TPI I;  3UIR C;  4BD9 B;  1BIK A;  1YKT B;  1P2I I;  1ADZ A;  1D0D A;  1P2M B;  2FTL I;  1BTI A;  2DDI A;  2KNT A;  3T62 D;  3D65 I;  4DTG K;  1OA5 5;  4NTW B;  2FTM B;  1UUB A;  3BTM I;  3AUG A;  1UUA A;  2LFL A;  3LDJ A;  1JC6 A;  1JV8 A;  9PTI A;  2IJO I;  3TGI I;  1MTN D;  3BTE I;  3BTH I;  1BPT A;  5JB7 A;  4ISL B;  3BTF I;  1BTH P;  1B0C A;  1KIG I;  1BRB I;  1TFX C;  2KAI I;  2J6D A;  2UUX A;  1F7Z I;  2M99 A;  4ISN B;  4DG4 C;  1T8O B;  7PTI A;  1AAL A;  3AUE A;  3GYM I;  3M7Q B;  2HEX A;  4WXV C;  8PTI A;  3BTK I;  1CO7 I;  1DEM A;  3BYB A;  1FAK I;  3BTD I;  4PTI A;  1ZR0 B;  2FI5 I;  1BHC A;  5C67 C;  2ZVX A;  3FP7 J;  1BUN B;  3P92 E;  3L33 E;  1BPI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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