1P2QB

Structural consequences of accommodation of four non-cognate amino-acid residues in the s1 pocket of bovine trypsin and chymotrypsin
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCFARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCLRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Bos taurus
molecule keywords Chymotrypsinogen A
total genus 11
structure length 58
sequence length 58
chains with identical sequence D
ec nomenclature
pdb deposition date 2003-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1p2qB00
1SHPA 1AALA 3WNYA 3BTMI 4NTXB 2W8XA 1AAPA 1G6XA 3BTHI 1BHCA 3BTDI 3FP8I 4ISNB 1BZXI 1YC0I 1YLCB 1UUBA 4NTWB 8PTIA 1BF0A 1DTXA 1MTND 1UUAA 1P2NB 1YKTB 2KNTA 3AUEA 1P2JI 1KNTA 2KCRA 3BTQI 1BPTA 2UUXA 3M7QB 1DENA 2FI5I 1T8OB 4Y10I 1TFXC 1PITA 1T8NB 2ODYE 5JB4A 1JV8A 1TOCR 1FANA 1D0DB 1DTKA 3AUHA 1LD6A 1KTHA 4DTGK 1BUNB 1NAGA 1OA65 3T62D 2LFKA 3BTTI 4U30W 3FP7J 3AUGA 4BQDA 2LFLA 3L33E 4Y0YI 2M01A 1CBWD 2HEXA 3LDMA 2FTLI 3BTWI 1T7CB 4BNRI 1P2MB 1BPIA 2TPII 3TGII 1BZ5A 3UIRC 1P2QB 1QLQA 3BTGI 9PTIA 3FP6I 4ISLB 4TPII 3GYMI 3AUIA 1P2KI 1KUNA 1T8MB 5JB6A 1BTHP 1BTIA 2ZJXA 1TAPA 2FI3I 2UUYB 4NTYB 2CA7A 3UOUB 3OFWA 7PTIA 3BYBA 4WXVC 5JB7A 1TPAI 1FY8I 3LDIA 3CI7A 3LDJA 3D65I 4BD9B 3BTEI 5JB5A 3TGKI 3BTFI 3TGJI 2PTCI 1EAWB 1TCPA 1BIKA 4WWYC 4Y11I 3TPII 1T8LB 2FTMB 1KIGI 4PTIA 1LD5A 1TAWB 2J6DA 2R9PE 2M99A 1BRBI 4DG4C 3AUBA 3P95E 2DDIA 1IRHA 1BRCI 2FI4I 6PTIA 3P92E 1FAKI 1CA0D 1OA55 1CO7I 2ZVXA 3AUDA 1D0DA 1ADZA 1P2OB 1JV9A 1P2II 3L3TE 1ZR0B 1F7ZI 1K6UA 1Y62A 1EJMB 1DEMA 2DDJA 4Y0ZI 5C67C 3BTKI 4ISOB 2JOTA 3U1JE 1ZJDB 2RA3C 1YLDB 3AUCA 2IJOI 2KAII 3OTJI 1JC6A 1B0CA 5PTIA 4U32X 1F5RI 2TGPI
chains in the Genus database with same CATH superfamily
1SHPA 1AALA 3WNYA 3BTMI 4NTXB 2W8XA 1AAPA 1G6XA 3BTHI 1BHCA 3BTDI 3FP8I 4ISNB 1BZXI 1YC0I 1YLCB 1UUBA 4NTWB 8PTIA 1BF0A 1DTXA 1MTND 1UUAA 1P2NB 1YKTB 2KNTA 3AUEA 1P2JI 1KNTA 2KCRA 3BTQI 1BPTA 2UUXA 3M7QB 1DENA 2FI5I 1T8OB 4Y10I 1TFXC 1PITA 1T8NB 2ODYE 5JB4A 1JV8A 1TOCR 1FANA 1D0DB 1DTKA 3AUHA 1LD6A 1KTHA 4DTGK 1BUNB 1NAGA 1OA65 3T62D 2LFKA 3BTTI 4U30W 3FP7J 3AUGA 4BQDA 2LFLA 3L33E 4Y0YI 2M01A 1CBWD 2HEXA 3LDMA 2FTLI 3BTWI 1T7CB 4BNRI 1P2MB 1BPIA 2TPII 3TGII 1BZ5A 3UIRC 1P2QB 1QLQA 3BTGI 9PTIA 3FP6I 4ISLB 4TPII 3GYMI 3AUIA 1P2KI 1KUNA 1T8MB 5JB6A 1BTHP 1BTIA 2ZJXA 1TAPA 2FI3I 2UUYB 4NTYB 2CA7A 3UOUB 3OFWA 7PTIA 3BYBA 4WXVC 5JB7A 1TPAI 1FY8I 3LDIA 3CI7A 3LDJA 3D65I 4BD9B 3BTEI 5JB5A 3TGKI 3BTFI 3TGJI 2PTCI 1EAWB 1TCPA 1BIKA 4WWYC 4Y11I 3TPII 1T8LB 2FTMB 1KIGI 4PTIA 1LD5A 1TAWB 2J6DA 2R9PE 2M99A 1BRBI 4DG4C 3AUBA 3P95E 2DDIA 1IRHA 1BRCI 2FI4I 6PTIA 3P92E 1FAKI 1CA0D 1OA55 1CO7I 2ZVXA 3AUDA 1D0DA 1ADZA 1P2OB 1JV9A 1P2II 3L3TE 1ZR0B 1F7ZI 1K6UA 1Y62A 1EJMB 1DEMA 2DDJA 4Y0ZI 5C67C 3BTKI 4ISOB 2JOTA 3U1JE 1ZJDB 2RA3C 1YLDB 3AUCA 2IJOI 2KAII 3OTJI 1JC6A 1B0CA 5PTIA 4U32X 1F5RI 2TGPI
chains in the Genus database with same CATH topology
1SHPA 1AALA 3WNYA 3BTMI 4NTXB 2W8XA 1AAPA 1G6XA 3BTHI 1BHCA 3BTDI 3FP8I 4ISNB 1BZXI 1YC0I 1YLCB 1UUBA 4NTWB 8PTIA 1BF0A 1DTXA 1MTND 1UUAA 1P2NB 1YKTB 2KNTA 3AUEA 1P2JI 1KNTA 2KCRA 3BTQI 1BPTA 2UUXA 3M7QB 1DENA 2FI5I 1T8OB 4Y10I 1TFXC 1PITA 1T8NB 2ODYE 5JB4A 1JV8A 1TOCR 1FANA 1D0DB 1DTKA 3AUHA 1LD6A 1KTHA 4DTGK 1BUNB 1NAGA 1OA65 3T62D 2LFKA 3BTTI 4U30W 3FP7J 3AUGA 4BQDA 2LFLA 3L33E 4Y0YI 2M01A 1CBWD 2HEXA 3LDMA 2FTLI 3BTWI 1T7CB 4BNRI 1P2MB 1BPIA 2TPII 3TGII 1BZ5A 3UIRC 1P2QB 1QLQA 3BTGI 9PTIA 3FP6I 4ISLB 4TPII 3GYMI 3AUIA 1P2KI 1KUNA 1T8MB 5JB6A 1BTHP 1BTIA 2ZJXA 1TAPA 2FI3I 2UUYB 4NTYB 2CA7A 3UOUB 3OFWA 7PTIA 3BYBA 4WXVC 5JB7A 1TPAI 1FY8I 3LDIA 3CI7A 3LDJA 3D65I 4BD9B 3BTEI 5JB5A 3TGKI 3BTFI 3TGJI 2PTCI 1EAWB 1TCPA 1BIKA 4WWYC 4Y11I 3TPII 1T8LB 2FTMB 1KIGI 4PTIA 1LD5A 1TAWB 2J6DA 2R9PE 2M99A 1BRBI 4DG4C 3AUBA 3P95E 2DDIA 1IRHA 1BRCI 2FI4I 6PTIA 3P92E 1FAKI 1CA0D 1OA55 1CO7I 2ZVXA 3AUDA 1D0DA 1ADZA 1P2OB 1JV9A 1P2II 3L3TE 1ZR0B 1F7ZI 1K6UA 1Y62A 1EJMB 1DEMA 2DDJA 4Y0ZI 5C67C 3BTKI 4ISOB 2JOTA 3U1JE 1ZJDB 2RA3C 1YLDB 3AUCA 2IJOI 2KAII 3OTJI 1JC6A 1B0CA 5PTIA 4U32X 1F5RI 2TGPI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SHP A;  1AAL A;  3WNY A;  3BTM I;  4NTX B;  2W8X A;  1AAP A;  1G6X A;  3BTH I;  1BHC A;  3BTD I;  3FP8 I;  4ISN B;  1BZX I;  1YC0 I;  1YLC B;  1UUB A;  4NTW B;  8PTI A;  1BF0 A;  1DTX A;  1MTN D;  1UUA A;  1P2N B;  1YKT B;  2KNT A;  3AUE A;  1P2J I;  1KNT A;  2KCR A;  3BTQ I;  1BPT A;  2UUX A;  3M7Q B;  1DEN A;  2FI5 I;  1T8O B;  4Y10 I;  1TFX C;  1PIT A;  1T8N B;  2ODY E;  5JB4 A;  1JV8 A;  1TOC R;  1FAN A;  1D0D B;  1DTK A;  3AUH A;  1LD6 A;  1KTH A;  4DTG K;  1BUN B;  1NAG A;  1OA6 5;  3T62 D;  2LFK A;  3BTT I;  4U30 W;  3FP7 J;  3AUG A;  4BQD A;  2LFL A;  3L33 E;  4Y0Y I;  2M01 A;  1CBW D;  2HEX A;  3LDM A;  2FTL I;  3BTW I;  1T7C B;  4BNR I;  1P2M B;  1BPI A;  2TPI I;  3TGI I;  1BZ5 A;  3UIR C;  1P2Q B;  1QLQ A;  3BTG I;  9PTI A;  3FP6 I;  4ISL B;  4TPI I;  3GYM I;  3AUI A;  1P2K I;  1KUN A;  1T8M B;  5JB6 A;  1BTH P;  1BTI A;  2ZJX A;  1TAP A;  2FI3 I;  2UUY B;  4NTY B;  2CA7 A;  3UOU B;  3OFW A;  7PTI A;  3BYB A;  4WXV C;  5JB7 A;  1TPA I;  1FY8 I;  3LDI A;  3CI7 A;  3LDJ A;  3D65 I;  4BD9 B;  3BTE I;  5JB5 A;  3TGK I;  3BTF I;  3TGJ I;  2PTC I;  1EAW B;  1TCP A;  1BIK A;  4WWY C;  4Y11 I;  3TPI I;  1T8L B;  2FTM B;  1KIG I;  4PTI A;  1LD5 A;  1TAW B;  2J6D A;  2R9P E;  2M99 A;  1BRB I;  4DG4 C;  3AUB A;  3P95 E;  2DDI A;  1IRH A;  1BRC I;  2FI4 I;  6PTI A;  3P92 E;  1FAK I;  1CA0 D;  1OA5 5;  1CO7 I;  2ZVX A;  3AUD A;  1D0D A;  1ADZ A;  1P2O B;  1JV9 A;  1P2I I;  3L3T E;  1ZR0 B;  1F7Z I;  1K6U A;  1Y62 A;  1EJM B;  1DEM A;  2DDJ A;  4Y0Z I;  5C67 C;  3BTK I;  4ISO B;  2JOT A;  3U1J E;  1ZJD B;  2RA3 C;  1YLD B;  3AUC A;  2IJO I;  2KAI I;  3OTJ I;  1JC6 A;  1B0C A;  5PTI A;  4U32 X;  1F5R I;  2TGP I; 
#chains in the Genus database with same CATH topology
 1SHP A;  1AAL A;  3WNY A;  3BTM I;  4NTX B;  2W8X A;  1AAP A;  1G6X A;  3BTH I;  1BHC A;  3BTD I;  3FP8 I;  4ISN B;  1BZX I;  1YC0 I;  1YLC B;  1UUB A;  4NTW B;  8PTI A;  1BF0 A;  1DTX A;  1MTN D;  1UUA A;  1P2N B;  1YKT B;  2KNT A;  3AUE A;  1P2J I;  1KNT A;  2KCR A;  3BTQ I;  1BPT A;  2UUX A;  3M7Q B;  1DEN A;  2FI5 I;  1T8O B;  4Y10 I;  1TFX C;  1PIT A;  1T8N B;  2ODY E;  5JB4 A;  1JV8 A;  1TOC R;  1FAN A;  1D0D B;  1DTK A;  3AUH A;  1LD6 A;  1KTH A;  4DTG K;  1BUN B;  1NAG A;  1OA6 5;  3T62 D;  2LFK A;  3BTT I;  4U30 W;  3FP7 J;  3AUG A;  4BQD A;  2LFL A;  3L33 E;  4Y0Y I;  2M01 A;  1CBW D;  2HEX A;  3LDM A;  2FTL I;  3BTW I;  1T7C B;  4BNR I;  1P2M B;  1BPI A;  2TPI I;  3TGI I;  1BZ5 A;  3UIR C;  1P2Q B;  1QLQ A;  3BTG I;  9PTI A;  3FP6 I;  4ISL B;  4TPI I;  3GYM I;  3AUI A;  1P2K I;  1KUN A;  1T8M B;  5JB6 A;  1BTH P;  1BTI A;  2ZJX A;  1TAP A;  2FI3 I;  2UUY B;  4NTY B;  2CA7 A;  3UOU B;  3OFW A;  7PTI A;  3BYB A;  4WXV C;  5JB7 A;  1TPA I;  1FY8 I;  3LDI A;  3CI7 A;  3LDJ A;  3D65 I;  4BD9 B;  3BTE I;  5JB5 A;  3TGK I;  3BTF I;  3TGJ I;  2PTC I;  1EAW B;  1TCP A;  1BIK A;  4WWY C;  4Y11 I;  3TPI I;  1T8L B;  2FTM B;  1KIG I;  4PTI A;  1LD5 A;  1TAW B;  2J6D A;  2R9P E;  2M99 A;  1BRB I;  4DG4 C;  3AUB A;  3P95 E;  2DDI A;  1IRH A;  1BRC I;  2FI4 I;  6PTI A;  3P92 E;  1FAK I;  1CA0 D;  1OA5 5;  1CO7 I;  2ZVX A;  3AUD A;  1D0D A;  1ADZ A;  1P2O B;  1JV9 A;  1P2I I;  3L3T E;  1ZR0 B;  1F7Z I;  1K6U A;  1Y62 A;  1EJM B;  1DEM A;  2DDJ A;  4Y0Z I;  5C67 C;  3BTK I;  4ISO B;  2JOT A;  3U1J E;  1ZJD B;  2RA3 C;  1YLD B;  3AUC A;  2IJO I;  2KAI I;  3OTJ I;  1JC6 A;  1B0C A;  5PTI A;  4U32 X;  1F5R I;  2TGP I; 
#chains in the Genus database with same CATH homology
 1SHP A;  1AAL A;  3WNY A;  3BTM I;  4NTX B;  2W8X A;  1AAP A;  1G6X A;  3BTH I;  1BHC A;  3BTD I;  3FP8 I;  4ISN B;  1BZX I;  1YC0 I;  1YLC B;  1UUB A;  4NTW B;  8PTI A;  1BF0 A;  1DTX A;  1MTN D;  1UUA A;  1P2N B;  1YKT B;  2KNT A;  3AUE A;  1P2J I;  1KNT A;  2KCR A;  3BTQ I;  1BPT A;  2UUX A;  3M7Q B;  1DEN A;  2FI5 I;  1T8O B;  4Y10 I;  1TFX C;  1PIT A;  1T8N B;  2ODY E;  5JB4 A;  1JV8 A;  1TOC R;  1FAN A;  1D0D B;  1DTK A;  3AUH A;  1LD6 A;  1KTH A;  4DTG K;  1BUN B;  1NAG A;  1OA6 5;  3T62 D;  2LFK A;  3BTT I;  4U30 W;  3FP7 J;  3AUG A;  4BQD A;  2LFL A;  3L33 E;  4Y0Y I;  2M01 A;  1CBW D;  2HEX A;  3LDM A;  2FTL I;  3BTW I;  1T7C B;  4BNR I;  1P2M B;  1BPI A;  2TPI I;  3TGI I;  1BZ5 A;  3UIR C;  1P2Q B;  1QLQ A;  3BTG I;  9PTI A;  3FP6 I;  4ISL B;  4TPI I;  3GYM I;  3AUI A;  1P2K I;  1KUN A;  1T8M B;  5JB6 A;  1BTH P;  1BTI A;  2ZJX A;  1TAP A;  2FI3 I;  2UUY B;  4NTY B;  2CA7 A;  3UOU B;  3OFW A;  7PTI A;  3BYB A;  4WXV C;  5JB7 A;  1TPA I;  1FY8 I;  3LDI A;  3CI7 A;  3LDJ A;  3D65 I;  4BD9 B;  3BTE I;  5JB5 A;  3TGK I;  3BTF I;  3TGJ I;  2PTC I;  1EAW B;  1TCP A;  1BIK A;  4WWY C;  4Y11 I;  3TPI I;  1T8L B;  2FTM B;  1KIG I;  4PTI A;  1LD5 A;  1TAW B;  2J6D A;  2R9P E;  2M99 A;  1BRB I;  4DG4 C;  3AUB A;  3P95 E;  2DDI A;  1IRH A;  1BRC I;  2FI4 I;  6PTI A;  3P92 E;  1FAK I;  1CA0 D;  1OA5 5;  1CO7 I;  2ZVX A;  3AUD A;  1D0D A;  1ADZ A;  1P2O B;  1JV9 A;  1P2I I;  3L3T E;  1ZR0 B;  1F7Z I;  1K6U A;  1Y62 A;  1EJM B;  1DEM A;  2DDJ A;  4Y0Z I;  5C67 C;  3BTK I;  4ISO B;  2JOT A;  3U1J E;  1ZJD B;  2RA3 C;  1YLD B;  3AUC A;  2IJO I;  2KAI I;  3OTJ I;  1JC6 A;  1B0C A;  5PTI A;  4U32 X;  1F5R I;  2TGP I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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