1TFGA

An unusual feature revealed by the crystal structure at 2.2 angstroms resolution of human transforming growth factor-beta2
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
112
structure length
112
Chain Sequence
ALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Growth factor
molecule keywords TRANSFORMING GROWTH FACTOR, BETA 2
publication title An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-beta 2.
pubmed doi rcsb
source organism Homo sapiens
total genus 23
structure length 112
sequence length 112
ec nomenclature
pdb deposition date 1992-11-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00019 TGF_beta Transforming growth factor beta like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 1tfgA00
5F3BC 5BQ8A 4BV4L 5JZ7A 5BQEB 1JPYA 4YCIC 2ARVA 1FL7A 1REWA 5HHXA 4QCIC 3EO1C 2GOOA 1TFGA 1SG1A 3BMPA 3EVSB 5HHCA 4HQXA 2H64A 3JVFA 1HCFA 4KV5A 1PDGA 5HHVA 2TGIA 5HK5A 1B8KA 5BQ8D 2X1WA 3KFDA 5HI3A 1ES7A 3V6BA 1KTZA 4LXRJ 1AGQA 4N1DA 1VPFA 2GH0C 2QJ9A 4UHYA 1QFWB 1HCNB 2QJAA 4MQWA 2XACA 2QCWA 1ZKZA 1VPPV 4YCGC 4EFVA 1HD4A 1WAQA 4GLNE 1NT3A 2H62A 3S1BV 2VPFA 1E9JA 1M4UA 4EDWV 5BQ8B 4MPLA 5HK5E 1BTGA 1BETA 1FL7B 4QAFC 5BPUA 2X1XE 1TGJA 1NYSB 1M4UL 3IJ2A 5BQCA 4AY9A 1SGFB 4UI2B 1AOCA 4ZBNA 2BHKA 4KXZA 1BJ1V 5BQBA 2VXSA 1FZVA 2P6AA 1CZ8V 2ASKA 5AEJA 5HI5A 1MKKA 2GNNA 5E4GA 1TZIV 1DZ7A 4MQWB 1LX5A 2QJBA 3BK3A 4X1JA 3SEKB 4FAOA 5FV2V 1BNDA 4EDXV 4EAXA 4HR9A 3QB4A 3QTKA 1WQ9A 1BMPA 1BNDB 5HHDA 1KATW 3MJGA 2C7WA 2XV7A 4GLSE 2GYRA 1HRPA 1NYUB 2R52A 3P9WA 5F3HI 4HSAA 3B4VA 2VWEA 4WPBA 2QCQA 2FJHV 4UI1A 3BUKA 4AY9B 1XWDA 5BQEA 1B98A 1WWWV 1XWDB 1FLTV 2ARPA 3BDYV 5FV1V 3FUBB 2B0UA 4ZFFC 1KLAA 1RV6V 1B8MA 3V2AA 4LXSJ 2PJYA 2V5EB 1MJVA 4KZNA 1S4YB 3RJRA 1B8MB 2KD3A 4UI0A 2QR0C 4HQUA 3HH2A 1REUA 1QTYR 5HI4A 1WQ9B 4MIDA 3E07A 4QHUC 1LXIA 1QFWA 1TZHV 1HCNA 1KLCA 1TGKA 2R53A 3MJKA 1HRPB 2GYZA 1MKGA 1WQ8A 4UHZA 4XPJA 4EC7A 3S1KV 2FJGV 2IFGE
chains in the Genus database with same CATH superfamily
5F3BC 5BQ8A 4BV4L 5JZ7A 5BQEB 1JPYA 4YCIC 2ARVA 1FL7A 1REWA 5HHXA 4QCIC 3EO1C 2GOOA 1TFGA 1SG1A 3BMPA 3EVSB 5HHCA 4HQXA 2H64A 3JVFA 1HCFA 4KV5A 1PDGA 5HHVA 2TGIA 5HK5A 1B8KA 5BQ8D 2X1WA 3KFDA 5HI3A 1ES7A 3V6BA 1KTZA 4LXRJ 1AGQA 4N1DA 1VPFA 2GH0C 2QJ9A 4UHYA 1QFWB 1HCNB 2QJAA 4MQWA 2XACA 2QCWA 1ZKZA 1VPPV 4YCGC 4EFVA 1HD4A 1WAQA 4GLNE 1NT3A 2H62A 3S1BV 2VPFA 1E9JA 1M4UA 4EDWV 5BQ8B 4MPLA 5HK5E 1BTGA 1BETA 1FL7B 4QAFC 5BPUA 2X1XE 1TGJA 1NYSB 1M4UL 3IJ2A 5BQCA 4AY9A 1SGFB 4UI2B 1AOCA 4ZBNA 2BHKA 4KXZA 1BJ1V 5BQBA 2VXSA 1FZVA 2P6AA 1CZ8V 2ASKA 5AEJA 5HI5A 1MKKA 2GNNA 5E4GA 1TZIV 1DZ7A 4MQWB 1LX5A 2QJBA 3BK3A 4X1JA 3SEKB 4FAOA 5FV2V 1BNDA 4EDXV 4EAXA 4HR9A 3QB4A 3QTKA 1WQ9A 1BMPA 1BNDB 5HHDA 1KATW 3MJGA 2C7WA 2XV7A 4GLSE 2GYRA 1HRPA 1NYUB 2R52A 3P9WA 5F3HI 4HSAA 3B4VA 2VWEA 4WPBA 2QCQA 2FJHV 4UI1A 3BUKA 4AY9B 1XWDA 5BQEA 1B98A 1WWWV 1XWDB 1FLTV 2ARPA 3BDYV 5FV1V 3FUBB 2B0UA 4ZFFC 1KLAA 1RV6V 1B8MA 3V2AA 4LXSJ 2PJYA 2V5EB 1MJVA 4KZNA 1S4YB 3RJRA 1B8MB 2KD3A 4UI0A 2QR0C 4HQUA 3HH2A 1REUA 1QTYR 5HI4A 1WQ9B 4MIDA 3E07A 4QHUC 1LXIA 1QFWA 1TZHV 1HCNA 1KLCA 1TGKA 2R53A 3MJKA 1HRPB 2GYZA 1MKGA 1WQ8A 4UHZA 4XPJA 4EC7A 3S1KV 2FJGV 2IFGE
chains in the Genus database with same CATH topology
5F3BC 5BQ8A 4BV4L 5JZ7A 5BQEB 1JPYA 4YCIC 2ARVA 1FL7A 1REWA 5HHXA 4QCIC 3EO1C 2GOOA 1TFGA 1SG1A 3BMPA 3EVSB 5HHCA 4HQXA 2H64A 3JVFA 1HCFA 4KV5A 1PDGA 5HHVA 2TGIA 5HK5A 1B8KA 5BQ8D 2X1WA 3KFDA 5HI3A 1ES7A 3V6BA 1KTZA 4LXRJ 1AGQA 4N1DA 1VPFA 2GH0C 2QJ9A 4UHYA 1QFWB 1HCNB 2QJAA 4MQWA 2XACA 2QCWA 1ZKZA 1VPPV 4YCGC 4EFVA 1HD4A 1WAQA 4GLNE 1NT3A 2H62A 3S1BV 2VPFA 1E9JA 1M4UA 4EDWV 5BQ8B 4MPLA 5HK5E 1BTGA 1BETA 1FL7B 4QAFC 5BPUA 2X1XE 1TGJA 1NYSB 1M4UL 3IJ2A 5BQCA 4AY9A 1SGFB 4UI2B 1AOCA 4ZBNA 2BHKA 4KXZA 1BJ1V 5BQBA 2VXSA 1FZVA 2P6AA 1CZ8V 2ASKA 5AEJA 5HI5A 1MKKA 2GNNA 5E4GA 1TZIV 1DZ7A 4MQWB 1LX5A 2QJBA 3BK3A 4X1JA 3SEKB 4FAOA 5FV2V 1BNDA 4EDXV 4EAXA 4HR9A 3QB4A 3QTKA 1WQ9A 1BMPA 1BNDB 5HHDA 1KATW 3MJGA 2C7WA 2XV7A 4GLSE 2GYRA 1HRPA 1NYUB 2R52A 3P9WA 5F3HI 4HSAA 3B4VA 2VWEA 4WPBA 2QCQA 2FJHV 4UI1A 3BUKA 4AY9B 1XWDA 5BQEA 1B98A 1WWWV 1XWDB 1FLTV 2ARPA 3BDYV 5FV1V 3FUBB 2B0UA 4ZFFC 1KLAA 1RV6V 1B8MA 3V2AA 4LXSJ 2PJYA 2V5EB 1MJVA 4KZNA 1S4YB 3RJRA 1B8MB 2KD3A 4UI0A 2QR0C 4HQUA 3HH2A 1REUA 1QTYR 5HI4A 1WQ9B 4MIDA 3E07A 4QHUC 1LXIA 1QFWA 1TZHV 1HCNA 1KLCA 1TGKA 2R53A 3MJKA 1HRPB 2GYZA 1MKGA 1WQ8A 4UHZA 4XPJA 4EC7A 3S1KV 2FJGV 2IFGE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5F3B C;  5BQ8 A;  4BV4 L;  5JZ7 A;  5BQE B;  1JPY A;  4YCI C;  2ARV A;  1FL7 A;  1REW A;  5HHX A;  4QCI C;  3EO1 C;  2GOO A;  1TFG A;  1SG1 A;  3BMP A;  3EVS B;  5HHC A;  4HQX A;  2H64 A;  3JVF A;  1HCF A;  4KV5 A;  1PDG A;  5HHV A;  2TGI A;  5HK5 A;  1B8K A;  5BQ8 D;  2X1W A;  3KFD A;  5HI3 A;  1ES7 A;  3V6B A;  1KTZ A;  4LXR J;  1AGQ A;  4N1D A;  1VPF A;  2GH0 C;  2QJ9 A;  4UHY A;  1QFW B;  1HCN B;  2QJA A;  4MQW A;  2XAC A;  2QCW A;  1ZKZ A;  1VPP V;  4YCG C;  4EFV A;  1HD4 A;  1WAQ A;  4GLN E;  1NT3 A;  2H62 A;  3S1B V;  2VPF A;  1E9J A;  1M4U A;  4EDW V;  5BQ8 B;  4MPL A;  5HK5 E;  1BTG A;  1BET A;  1FL7 B;  4QAF C;  5BPU A;  2X1X E;  1TGJ A;  1NYS B;  1M4U L;  3IJ2 A;  5BQC A;  4AY9 A;  1SGF B;  4UI2 B;  1AOC A;  4ZBN A;  2BHK A;  4KXZ A;  1BJ1 V;  5BQB A;  2VXS A;  1FZV A;  2P6A A;  1CZ8 V;  2ASK A;  5AEJ A;  5HI5 A;  1MKK A;  2GNN A;  5E4G A;  1TZI V;  1DZ7 A;  4MQW B;  1LX5 A;  2QJB A;  3BK3 A;  4X1J A;  3SEK B;  4FAO A;  5FV2 V;  1BND A;  4EDX V;  4EAX A;  4HR9 A;  3QB4 A;  3QTK A;  1WQ9 A;  1BMP A;  1BND B;  5HHD A;  1KAT W;  3MJG A;  2C7W A;  2XV7 A;  4GLS E;  2GYR A;  1HRP A;  1NYU B;  2R52 A;  3P9W A;  5F3H I;  4HSA A;  3B4V A;  2VWE A;  4WPB A;  2QCQ A;  2FJH V;  4UI1 A;  3BUK A;  4AY9 B;  1XWD A;  5BQE A;  1B98 A;  1WWW V;  1XWD B;  1FLT V;  2ARP A;  3BDY V;  5FV1 V;  3FUB B;  2B0U A;  4ZFF C;  1KLA A;  1RV6 V;  1B8M A;  3V2A A;  4LXS J;  2PJY A;  2V5E B;  1MJV A;  4KZN A;  1S4Y B;  3RJR A;  1B8M B;  2KD3 A;  4UI0 A;  2QR0 C;  4HQU A;  3HH2 A;  1REU A;  1QTY R;  5HI4 A;  1WQ9 B;  4MID A;  3E07 A;  4QHU C;  1LXI A;  1QFW A;  1TZH V;  1HCN A;  1KLC A;  1TGK A;  2R53 A;  3MJK A;  1HRP B;  2GYZ A;  1MKG A;  1WQ8 A;  4UHZ A;  4XPJ A;  4EC7 A;  3S1K V;  2FJG V;  2IFG E; 
#chains in the Genus database with same CATH topology
 5F3B C;  5BQ8 A;  4BV4 L;  5JZ7 A;  5BQE B;  1JPY A;  4YCI C;  2ARV A;  1FL7 A;  1REW A;  5HHX A;  4QCI C;  3EO1 C;  2GOO A;  1TFG A;  1SG1 A;  3BMP A;  3EVS B;  5HHC A;  4HQX A;  2H64 A;  3JVF A;  1HCF A;  4KV5 A;  1PDG A;  5HHV A;  2TGI A;  5HK5 A;  1B8K A;  5BQ8 D;  2X1W A;  3KFD A;  5HI3 A;  1ES7 A;  3V6B A;  1KTZ A;  4LXR J;  1AGQ A;  4N1D A;  1VPF A;  2GH0 C;  2QJ9 A;  4UHY A;  1QFW B;  1HCN B;  2QJA A;  4MQW A;  2XAC A;  2QCW A;  1ZKZ A;  1VPP V;  4YCG C;  4EFV A;  1HD4 A;  1WAQ A;  4GLN E;  1NT3 A;  2H62 A;  3S1B V;  2VPF A;  1E9J A;  1M4U A;  4EDW V;  5BQ8 B;  4MPL A;  5HK5 E;  1BTG A;  1BET A;  1FL7 B;  4QAF C;  5BPU A;  2X1X E;  1TGJ A;  1NYS B;  1M4U L;  3IJ2 A;  5BQC A;  4AY9 A;  1SGF B;  4UI2 B;  1AOC A;  4ZBN A;  2BHK A;  4KXZ A;  1BJ1 V;  5BQB A;  2VXS A;  1FZV A;  2P6A A;  1CZ8 V;  2ASK A;  5AEJ A;  5HI5 A;  1MKK A;  2GNN A;  5E4G A;  1TZI V;  1DZ7 A;  4MQW B;  1LX5 A;  2QJB A;  3BK3 A;  4X1J A;  3SEK B;  4FAO A;  5FV2 V;  1BND A;  4EDX V;  4EAX A;  4HR9 A;  3QB4 A;  3QTK A;  1WQ9 A;  1BMP A;  1BND B;  5HHD A;  1KAT W;  3MJG A;  2C7W A;  2XV7 A;  4GLS E;  2GYR A;  1HRP A;  1NYU B;  2R52 A;  3P9W A;  5F3H I;  4HSA A;  3B4V A;  2VWE A;  4WPB A;  2QCQ A;  2FJH V;  4UI1 A;  3BUK A;  4AY9 B;  1XWD A;  5BQE A;  1B98 A;  1WWW V;  1XWD B;  1FLT V;  2ARP A;  3BDY V;  5FV1 V;  3FUB B;  2B0U A;  4ZFF C;  1KLA A;  1RV6 V;  1B8M A;  3V2A A;  4LXS J;  2PJY A;  2V5E B;  1MJV A;  4KZN A;  1S4Y B;  3RJR A;  1B8M B;  2KD3 A;  4UI0 A;  2QR0 C;  4HQU A;  3HH2 A;  1REU A;  1QTY R;  5HI4 A;  1WQ9 B;  4MID A;  3E07 A;  4QHU C;  1LXI A;  1QFW A;  1TZH V;  1HCN A;  1KLC A;  1TGK A;  2R53 A;  3MJK A;  1HRP B;  2GYZ A;  1MKG A;  1WQ8 A;  4UHZ A;  4XPJ A;  4EC7 A;  3S1K V;  2FJG V;  2IFG E; 
#chains in the Genus database with same CATH homology
 5F3B C;  5BQ8 A;  4BV4 L;  5JZ7 A;  5BQE B;  1JPY A;  4YCI C;  2ARV A;  1FL7 A;  1REW A;  5HHX A;  4QCI C;  3EO1 C;  2GOO A;  1TFG A;  1SG1 A;  3BMP A;  3EVS B;  5HHC A;  4HQX A;  2H64 A;  3JVF A;  1HCF A;  4KV5 A;  1PDG A;  5HHV A;  2TGI A;  5HK5 A;  1B8K A;  5BQ8 D;  2X1W A;  3KFD A;  5HI3 A;  1ES7 A;  3V6B A;  1KTZ A;  4LXR J;  1AGQ A;  4N1D A;  1VPF A;  2GH0 C;  2QJ9 A;  4UHY A;  1QFW B;  1HCN B;  2QJA A;  4MQW A;  2XAC A;  2QCW A;  1ZKZ A;  1VPP V;  4YCG C;  4EFV A;  1HD4 A;  1WAQ A;  4GLN E;  1NT3 A;  2H62 A;  3S1B V;  2VPF A;  1E9J A;  1M4U A;  4EDW V;  5BQ8 B;  4MPL A;  5HK5 E;  1BTG A;  1BET A;  1FL7 B;  4QAF C;  5BPU A;  2X1X E;  1TGJ A;  1NYS B;  1M4U L;  3IJ2 A;  5BQC A;  4AY9 A;  1SGF B;  4UI2 B;  1AOC A;  4ZBN A;  2BHK A;  4KXZ A;  1BJ1 V;  5BQB A;  2VXS A;  1FZV A;  2P6A A;  1CZ8 V;  2ASK A;  5AEJ A;  5HI5 A;  1MKK A;  2GNN A;  5E4G A;  1TZI V;  1DZ7 A;  4MQW B;  1LX5 A;  2QJB A;  3BK3 A;  4X1J A;  3SEK B;  4FAO A;  5FV2 V;  1BND A;  4EDX V;  4EAX A;  4HR9 A;  3QB4 A;  3QTK A;  1WQ9 A;  1BMP A;  1BND B;  5HHD A;  1KAT W;  3MJG A;  2C7W A;  2XV7 A;  4GLS E;  2GYR A;  1HRP A;  1NYU B;  2R52 A;  3P9W A;  5F3H I;  4HSA A;  3B4V A;  2VWE A;  4WPB A;  2QCQ A;  2FJH V;  4UI1 A;  3BUK A;  4AY9 B;  1XWD A;  5BQE A;  1B98 A;  1WWW V;  1XWD B;  1FLT V;  2ARP A;  3BDY V;  5FV1 V;  3FUB B;  2B0U A;  4ZFF C;  1KLA A;  1RV6 V;  1B8M A;  3V2A A;  4LXS J;  2PJY A;  2V5E B;  1MJV A;  4KZN A;  1S4Y B;  3RJR A;  1B8M B;  2KD3 A;  4UI0 A;  2QR0 C;  4HQU A;  3HH2 A;  1REU A;  1QTY R;  5HI4 A;  1WQ9 B;  4MID A;  3E07 A;  4QHU C;  1LXI A;  1QFW A;  1TZH V;  1HCN A;  1KLC A;  1TGK A;  2R53 A;  3MJK A;  1HRP B;  2GYZ A;  1MKG A;  1WQ8 A;  4UHZ A;  4XPJ A;  4EC7 A;  3S1K V;  2FJG V;  2IFG E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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