1TFXC

Complex of the second kunitz domain of tissue factor pathway inhibitor with porcine trypsin
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
58
structure length
58
Chain Sequence
KPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa.
pubmed doi rcsb
molecule tags Complex (serine protease/inhibitor)
source organism Sus scrofa
molecule keywords TRYPSIN
total genus 12
structure length 58
sequence length 58
chains with identical sequence D
ec nomenclature
pdb deposition date 1997-01-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1tfxC00
1B0CA 1AAPA 1TPAI 5JB5A 4NTXB 2UUXA 4WWYC 1IRHA 2ZJXA 3BTKI 2FI5I 3WNYA 4BNRI 1P2II 1BPTA 1P2KI 1T8NB 3FP7J 8PTIA 1ADZA 1ZJDB 1D0DB 3M7QB 3L33E 3OTJI 2CA7A 3OFWA 1P2NB 1BZXI 1CBWD 4PTIA 3L3TE 4ISLB 1YLDB 1T7CB 1K6UA 2FTLI 3AUEA 3AUDA 1ZR0B 5JB7A 3BTFI 1T8MB 1P2JI 1TAPA 3LDMA 2PTCI 2W8XA 1BRBI 1YKTB 2FI3I 1KNTA 1TOCR 1UUAA 1DEMA 1OA65 4TPII 1AALA 1EAWB 2KCRA 3TPII 2FI4I 1BPIA 3P92E 3AUIA 3TGJI 1YLCB 1OA55 1TFXC 1JV9A 1UUBA 4U32X 1DENA 1TCPA 3FP6I 2M99A 3BTWI 4NTWB 3T62D 4U30W 1T8OB 2KNTA 2UUYB 3TGKI 4ISNB 1P2QB 3AUGA 1BHCA 2LFKA 4DG4C 1MTND 1FANA 1F7ZI 4WXVC 3BTMI 1P2OB 2IJOI 2M01A 9PTIA 2HEXA 1TAWB 3GYMI 1JC6A 1G6XA 1BTHP 1BF0A 2ZVXA 1NAGA 3AUHA 1JV8A 1BUNB 1FAKI 1LD5A 3FP8I 1YC0I 3CI7A 1KIGI 2DDJA 4ISOB 5C67C 1P2MB 2FTMB 3BTQI 1BIKA 2J6DA 3BTEI 1DTXA 1BRCI 2R9PE 4Y10I 1BZ5A 3UIRC 1PITA 2TGPI 1KTHA 4DTGK 1T8LB 3U1JE 1BTIA 1SHPA 5JB4A 1FY8I 1F5RI 1EJMB 2JOTA 1D0DA 3AUBA 4Y0YI 3TGII 1DTKA 1Y62A 3LDIA 2RA3C 2TPII 1CO7I 4BQDA 3BTGI 4Y11I 2ODYE 3UOUB 4NTYB 1QLQA 1KUNA 1CA0D 3P95E 4Y0ZI 4BD9B 3BYBA 7PTIA 3D65I 3LDJA 6PTIA 5PTIA 3BTHI 3AUCA 5JB6A 2LFLA 3BTTI 2DDIA 3BTDI 2KAII 1LD6A
chains in the Genus database with same CATH superfamily
1B0CA 1AAPA 1TPAI 5JB5A 4NTXB 2UUXA 4WWYC 1IRHA 2ZJXA 3BTKI 2FI5I 3WNYA 4BNRI 1P2II 1BPTA 1P2KI 1T8NB 3FP7J 8PTIA 1ADZA 1ZJDB 1D0DB 3M7QB 3L33E 3OTJI 2CA7A 3OFWA 1P2NB 1BZXI 1CBWD 4PTIA 3L3TE 4ISLB 1YLDB 1T7CB 1K6UA 2FTLI 3AUEA 3AUDA 1ZR0B 5JB7A 3BTFI 1T8MB 1P2JI 1TAPA 3LDMA 2PTCI 2W8XA 1BRBI 1YKTB 2FI3I 1KNTA 1TOCR 1UUAA 1DEMA 1OA65 4TPII 1AALA 1EAWB 2KCRA 3TPII 2FI4I 1BPIA 3P92E 3AUIA 3TGJI 1YLCB 1OA55 1TFXC 1JV9A 1UUBA 4U32X 1DENA 1TCPA 3FP6I 2M99A 3BTWI 4NTWB 3T62D 4U30W 1T8OB 2KNTA 2UUYB 3TGKI 4ISNB 1P2QB 3AUGA 1BHCA 2LFKA 4DG4C 1MTND 1FANA 1F7ZI 4WXVC 3BTMI 1P2OB 2IJOI 2M01A 9PTIA 2HEXA 1TAWB 3GYMI 1JC6A 1G6XA 1BTHP 1BF0A 2ZVXA 1NAGA 3AUHA 1JV8A 1BUNB 1FAKI 1LD5A 3FP8I 1YC0I 3CI7A 1KIGI 2DDJA 4ISOB 5C67C 1P2MB 2FTMB 3BTQI 1BIKA 2J6DA 3BTEI 1DTXA 1BRCI 2R9PE 4Y10I 1BZ5A 3UIRC 1PITA 2TGPI 1KTHA 4DTGK 1T8LB 3U1JE 1BTIA 1SHPA 5JB4A 1FY8I 1F5RI 1EJMB 2JOTA 1D0DA 3AUBA 4Y0YI 3TGII 1DTKA 1Y62A 3LDIA 2RA3C 2TPII 1CO7I 4BQDA 3BTGI 4Y11I 2ODYE 3UOUB 4NTYB 1QLQA 1KUNA 1CA0D 3P95E 4Y0ZI 4BD9B 3BYBA 7PTIA 3D65I 3LDJA 6PTIA 5PTIA 3BTHI 3AUCA 5JB6A 2LFLA 3BTTI 2DDIA 3BTDI 2KAII 1LD6A
chains in the Genus database with same CATH topology
1B0CA 1AAPA 1TPAI 5JB5A 4NTXB 2UUXA 4WWYC 1IRHA 2ZJXA 3BTKI 2FI5I 3WNYA 4BNRI 1P2II 1BPTA 1P2KI 1T8NB 3FP7J 8PTIA 1ADZA 1ZJDB 1D0DB 3M7QB 3L33E 3OTJI 2CA7A 3OFWA 1P2NB 1BZXI 1CBWD 4PTIA 3L3TE 4ISLB 1YLDB 1T7CB 1K6UA 2FTLI 3AUEA 3AUDA 1ZR0B 5JB7A 3BTFI 1T8MB 1P2JI 1TAPA 3LDMA 2PTCI 2W8XA 1BRBI 1YKTB 2FI3I 1KNTA 1TOCR 1UUAA 1DEMA 1OA65 4TPII 1AALA 1EAWB 2KCRA 3TPII 2FI4I 1BPIA 3P92E 3AUIA 3TGJI 1YLCB 1OA55 1TFXC 1JV9A 1UUBA 4U32X 1DENA 1TCPA 3FP6I 2M99A 3BTWI 4NTWB 3T62D 4U30W 1T8OB 2KNTA 2UUYB 3TGKI 4ISNB 1P2QB 3AUGA 1BHCA 2LFKA 4DG4C 1MTND 1FANA 1F7ZI 4WXVC 3BTMI 1P2OB 2IJOI 2M01A 9PTIA 2HEXA 1TAWB 3GYMI 1JC6A 1G6XA 1BTHP 1BF0A 2ZVXA 1NAGA 3AUHA 1JV8A 1BUNB 1FAKI 1LD5A 3FP8I 1YC0I 3CI7A 1KIGI 2DDJA 4ISOB 5C67C 1P2MB 2FTMB 3BTQI 1BIKA 2J6DA 3BTEI 1DTXA 1BRCI 2R9PE 4Y10I 1BZ5A 3UIRC 1PITA 2TGPI 1KTHA 4DTGK 1T8LB 3U1JE 1BTIA 1SHPA 5JB4A 1FY8I 1F5RI 1EJMB 2JOTA 1D0DA 3AUBA 4Y0YI 3TGII 1DTKA 1Y62A 3LDIA 2RA3C 2TPII 1CO7I 4BQDA 3BTGI 4Y11I 2ODYE 3UOUB 4NTYB 1QLQA 1KUNA 1CA0D 3P95E 4Y0ZI 4BD9B 3BYBA 7PTIA 3D65I 3LDJA 6PTIA 5PTIA 3BTHI 3AUCA 5JB6A 2LFLA 3BTTI 2DDIA 3BTDI 2KAII 1LD6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1B0C A;  1AAP A;  1TPA I;  5JB5 A;  4NTX B;  2UUX A;  4WWY C;  1IRH A;  2ZJX A;  3BTK I;  2FI5 I;  3WNY A;  4BNR I;  1P2I I;  1BPT A;  1P2K I;  1T8N B;  3FP7 J;  8PTI A;  1ADZ A;  1ZJD B;  1D0D B;  3M7Q B;  3L33 E;  3OTJ I;  2CA7 A;  3OFW A;  1P2N B;  1BZX I;  1CBW D;  4PTI A;  3L3T E;  4ISL B;  1YLD B;  1T7C B;  1K6U A;  2FTL I;  3AUE A;  3AUD A;  1ZR0 B;  5JB7 A;  3BTF I;  1T8M B;  1P2J I;  1TAP A;  3LDM A;  2PTC I;  2W8X A;  1BRB I;  1YKT B;  2FI3 I;  1KNT A;  1TOC R;  1UUA A;  1DEM A;  1OA6 5;  4TPI I;  1AAL A;  1EAW B;  2KCR A;  3TPI I;  2FI4 I;  1BPI A;  3P92 E;  3AUI A;  3TGJ I;  1YLC B;  1OA5 5;  1TFX C;  1JV9 A;  1UUB A;  4U32 X;  1DEN A;  1TCP A;  3FP6 I;  2M99 A;  3BTW I;  4NTW B;  3T62 D;  4U30 W;  1T8O B;  2KNT A;  2UUY B;  3TGK I;  4ISN B;  1P2Q B;  3AUG A;  1BHC A;  2LFK A;  4DG4 C;  1MTN D;  1FAN A;  1F7Z I;  4WXV C;  3BTM I;  1P2O B;  2IJO I;  2M01 A;  9PTI A;  2HEX A;  1TAW B;  3GYM I;  1JC6 A;  1G6X A;  1BTH P;  1BF0 A;  2ZVX A;  1NAG A;  3AUH A;  1JV8 A;  1BUN B;  1FAK I;  1LD5 A;  3FP8 I;  1YC0 I;  3CI7 A;  1KIG I;  2DDJ A;  4ISO B;  5C67 C;  1P2M B;  2FTM B;  3BTQ I;  1BIK A;  2J6D A;  3BTE I;  1DTX A;  1BRC I;  2R9P E;  4Y10 I;  1BZ5 A;  3UIR C;  1PIT A;  2TGP I;  1KTH A;  4DTG K;  1T8L B;  3U1J E;  1BTI A;  1SHP A;  5JB4 A;  1FY8 I;  1F5R I;  1EJM B;  2JOT A;  1D0D A;  3AUB A;  4Y0Y I;  3TGI I;  1DTK A;  1Y62 A;  3LDI A;  2RA3 C;  2TPI I;  1CO7 I;  4BQD A;  3BTG I;  4Y11 I;  2ODY E;  3UOU B;  4NTY B;  1QLQ A;  1KUN A;  1CA0 D;  3P95 E;  4Y0Z I;  4BD9 B;  3BYB A;  7PTI A;  3D65 I;  3LDJ A;  6PTI A;  5PTI A;  3BTH I;  3AUC A;  5JB6 A;  2LFL A;  3BTT I;  2DDI A;  3BTD I;  2KAI I;  1LD6 A; 
#chains in the Genus database with same CATH topology
 1B0C A;  1AAP A;  1TPA I;  5JB5 A;  4NTX B;  2UUX A;  4WWY C;  1IRH A;  2ZJX A;  3BTK I;  2FI5 I;  3WNY A;  4BNR I;  1P2I I;  1BPT A;  1P2K I;  1T8N B;  3FP7 J;  8PTI A;  1ADZ A;  1ZJD B;  1D0D B;  3M7Q B;  3L33 E;  3OTJ I;  2CA7 A;  3OFW A;  1P2N B;  1BZX I;  1CBW D;  4PTI A;  3L3T E;  4ISL B;  1YLD B;  1T7C B;  1K6U A;  2FTL I;  3AUE A;  3AUD A;  1ZR0 B;  5JB7 A;  3BTF I;  1T8M B;  1P2J I;  1TAP A;  3LDM A;  2PTC I;  2W8X A;  1BRB I;  1YKT B;  2FI3 I;  1KNT A;  1TOC R;  1UUA A;  1DEM A;  1OA6 5;  4TPI I;  1AAL A;  1EAW B;  2KCR A;  3TPI I;  2FI4 I;  1BPI A;  3P92 E;  3AUI A;  3TGJ I;  1YLC B;  1OA5 5;  1TFX C;  1JV9 A;  1UUB A;  4U32 X;  1DEN A;  1TCP A;  3FP6 I;  2M99 A;  3BTW I;  4NTW B;  3T62 D;  4U30 W;  1T8O B;  2KNT A;  2UUY B;  3TGK I;  4ISN B;  1P2Q B;  3AUG A;  1BHC A;  2LFK A;  4DG4 C;  1MTN D;  1FAN A;  1F7Z I;  4WXV C;  3BTM I;  1P2O B;  2IJO I;  2M01 A;  9PTI A;  2HEX A;  1TAW B;  3GYM I;  1JC6 A;  1G6X A;  1BTH P;  1BF0 A;  2ZVX A;  1NAG A;  3AUH A;  1JV8 A;  1BUN B;  1FAK I;  1LD5 A;  3FP8 I;  1YC0 I;  3CI7 A;  1KIG I;  2DDJ A;  4ISO B;  5C67 C;  1P2M B;  2FTM B;  3BTQ I;  1BIK A;  2J6D A;  3BTE I;  1DTX A;  1BRC I;  2R9P E;  4Y10 I;  1BZ5 A;  3UIR C;  1PIT A;  2TGP I;  1KTH A;  4DTG K;  1T8L B;  3U1J E;  1BTI A;  1SHP A;  5JB4 A;  1FY8 I;  1F5R I;  1EJM B;  2JOT A;  1D0D A;  3AUB A;  4Y0Y I;  3TGI I;  1DTK A;  1Y62 A;  3LDI A;  2RA3 C;  2TPI I;  1CO7 I;  4BQD A;  3BTG I;  4Y11 I;  2ODY E;  3UOU B;  4NTY B;  1QLQ A;  1KUN A;  1CA0 D;  3P95 E;  4Y0Z I;  4BD9 B;  3BYB A;  7PTI A;  3D65 I;  3LDJ A;  6PTI A;  5PTI A;  3BTH I;  3AUC A;  5JB6 A;  2LFL A;  3BTT I;  2DDI A;  3BTD I;  2KAI I;  1LD6 A; 
#chains in the Genus database with same CATH homology
 1B0C A;  1AAP A;  1TPA I;  5JB5 A;  4NTX B;  2UUX A;  4WWY C;  1IRH A;  2ZJX A;  3BTK I;  2FI5 I;  3WNY A;  4BNR I;  1P2I I;  1BPT A;  1P2K I;  1T8N B;  3FP7 J;  8PTI A;  1ADZ A;  1ZJD B;  1D0D B;  3M7Q B;  3L33 E;  3OTJ I;  2CA7 A;  3OFW A;  1P2N B;  1BZX I;  1CBW D;  4PTI A;  3L3T E;  4ISL B;  1YLD B;  1T7C B;  1K6U A;  2FTL I;  3AUE A;  3AUD A;  1ZR0 B;  5JB7 A;  3BTF I;  1T8M B;  1P2J I;  1TAP A;  3LDM A;  2PTC I;  2W8X A;  1BRB I;  1YKT B;  2FI3 I;  1KNT A;  1TOC R;  1UUA A;  1DEM A;  1OA6 5;  4TPI I;  1AAL A;  1EAW B;  2KCR A;  3TPI I;  2FI4 I;  1BPI A;  3P92 E;  3AUI A;  3TGJ I;  1YLC B;  1OA5 5;  1TFX C;  1JV9 A;  1UUB A;  4U32 X;  1DEN A;  1TCP A;  3FP6 I;  2M99 A;  3BTW I;  4NTW B;  3T62 D;  4U30 W;  1T8O B;  2KNT A;  2UUY B;  3TGK I;  4ISN B;  1P2Q B;  3AUG A;  1BHC A;  2LFK A;  4DG4 C;  1MTN D;  1FAN A;  1F7Z I;  4WXV C;  3BTM I;  1P2O B;  2IJO I;  2M01 A;  9PTI A;  2HEX A;  1TAW B;  3GYM I;  1JC6 A;  1G6X A;  1BTH P;  1BF0 A;  2ZVX A;  1NAG A;  3AUH A;  1JV8 A;  1BUN B;  1FAK I;  1LD5 A;  3FP8 I;  1YC0 I;  3CI7 A;  1KIG I;  2DDJ A;  4ISO B;  5C67 C;  1P2M B;  2FTM B;  3BTQ I;  1BIK A;  2J6D A;  3BTE I;  1DTX A;  1BRC I;  2R9P E;  4Y10 I;  1BZ5 A;  3UIR C;  1PIT A;  2TGP I;  1KTH A;  4DTG K;  1T8L B;  3U1J E;  1BTI A;  1SHP A;  5JB4 A;  1FY8 I;  1F5R I;  1EJM B;  2JOT A;  1D0D A;  3AUB A;  4Y0Y I;  3TGI I;  1DTK A;  1Y62 A;  3LDI A;  2RA3 C;  2TPI I;  1CO7 I;  4BQD A;  3BTG I;  4Y11 I;  2ODY E;  3UOU B;  4NTY B;  1QLQ A;  1KUN A;  1CA0 D;  3P95 E;  4Y0Z I;  4BD9 B;  3BYB A;  7PTI A;  3D65 I;  3LDJ A;  6PTI A;  5PTI A;  3BTH I;  3AUC A;  5JB6 A;  2LFL A;  3BTT I;  2DDI A;  3BTD I;  2KAI I;  1LD6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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