1Y6VA

Structure of e. coli alkaline phosphatase in presence of cobalt at 1.60 a resolution
Total Genus 163
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase(,).
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Alkaline phosphatase
total genus 163
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2004-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1y6vA00
1ZEBA 1KH7A 1O99A 3WAWA 1ANJA 1AJAA 1ZEDA 2IUCA 4KM4A 3UNYA 3NVLA 3T02A 2W5WA 4LR8A 1Y7AA 4UPLA 5AJ9A 4CYSA 1E1ZP 5DLTA 3IDDA 2W5SA 2XR9A 3CMRA 5TJ3A 2ANHA 1HDHA 1KH4A 1ZEFA 4ZG6A 3MK0A 3WAXA 4FDIA 1K7HA 1O98A 4LRDA 3UN5A 1N2KA 2G9YA 4NWJA 3NKRA 3DPCA 4FDJA 4QAXA 3UN3A 1P49A 2XRGA 3NKPA 3OT9A 2D1GA 3BDGB 4UPKA 3TX0A 1ALJA 3MK1A 4TN0A 3B5QA 4LR9A 1E3CP 3ED4A 1AUKA 3IGZB 5IJQA 4UPIA 3NKMA 4MIVA 4UOPA 3UO0A 5GRRA 5HRTA 1AJBA 3E2DA 4NWXA 4CYRA 4B56A 1E33P 1EI6A 3M8WA 4LREA 4KJDA 2GA3A 3WBHA 1ED9A 3Q3QA 1SHNA 1B8JA 5EGEA 4LR7A 4ZG9A 2W8SA 1HQAA 2GLQA 3NKNA 4CXUA 2W5QA 1AJCA 1ED8A 2W5RA 3M7VA 3T00A 2QZUA 2X98A 1EW2A 4UPHA 1ALKA 5KXAA 4GTZA 4GTWA 4ZG7A 1KH9A 4MY4A 2GSUA 1E2SP 3DYCA 1ANIA 5L0BA 4ZGAA 5IJSA 2W5VA 3WAYA 1EW9A 4UOOA 4UORA 2IUCB 3SZZA 1N2LA 2GSNA 3BDGA 2W5XA 1AJDA 5INHA 5LIAA 2VQRA 4GTXA 3TG0A 4KAVA 1Y6VA 4LQYA 4LR2A 4YR1A 3T01A 1FSUA 1ELZA 3M8ZA 4MHXA 5EGHA 4CXSA 1ELXA 2W5TA 3BDHA 5LRMA 1EJJA 1URAA 3MK2A 1EW8A 4GTYA 1SHQA 2IFYA 3NKOA 3IGYB 3BDFA 4N7TA 1ELYA 1KHNA 4LRFA 5DLVA 1KHKA 4LRCA 4CXKA 5C66A 1KHJA 1KHLA 2W8DA 3UN2A 3M8YA 2GSOA 3WAVA 5LRNA 2ZKTA 3A52A 5K4PA 3LXQA 5DLWA 1HJKA 1ALHA 3SZYA 1KH5A 3TWZA 1EQJA 4KAYA 4KJGA 4LRAA 3NKQA 5L0EA 3KD8A 5LQQA 1ALIA 5L0KA 1URBA 4LRBA 2RH6A 5GOVA
chains in the Genus database with same CATH superfamily
1ZEBA 1KH7A 1O99A 3WAWA 1ANJA 1AJAA 1ZEDA 2IUCA 4KM4A 3UNYA 3NVLA 3T02A 2W5WA 4LR8A 1Y7AA 4UPLA 5AJ9A 4CYSA 1E1ZP 5DLTA 3IDDA 2W5SA 2XR9A 3CMRA 5TJ3A 2ANHA 1HDHA 1KH4A 1ZEFA 4ZG6A 3MK0A 3WAXA 4FDIA 1K7HA 1O98A 4LRDA 3UN5A 1N2KA 2G9YA 4NWJA 3NKRA 3DPCA 4FDJA 4QAXA 3UN3A 1P49A 2XRGA 3NKPA 3OT9A 2D1GA 3BDGB 4UPKA 3TX0A 1ALJA 3MK1A 4TN0A 3B5QA 4LR9A 1E3CP 3ED4A 1AUKA 3IGZB 5IJQA 4UPIA 3NKMA 4MIVA 4UOPA 3UO0A 5GRRA 5HRTA 1AJBA 3E2DA 4NWXA 4CYRA 4B56A 1E33P 1EI6A 3M8WA 4LREA 4KJDA 2GA3A 3WBHA 1ED9A 3Q3QA 1SHNA 1B8JA 5EGEA 4LR7A 4ZG9A 2W8SA 1HQAA 2GLQA 3NKNA 4CXUA 2W5QA 1AJCA 1ED8A 2W5RA 3M7VA 3T00A 2QZUA 2X98A 1EW2A 4UPHA 1ALKA 5KXAA 4GTZA 4GTWA 4ZG7A 1KH9A 4MY4A 2GSUA 1E2SP 3DYCA 1ANIA 5L0BA 4ZGAA 5IJSA 2W5VA 3WAYA 1EW9A 4UOOA 4UORA 2IUCB 3SZZA 1N2LA 2GSNA 3BDGA 2W5XA 1AJDA 5INHA 5LIAA 2VQRA 4GTXA 3TG0A 4KAVA 1Y6VA 4LQYA 4LR2A 4YR1A 3T01A 1FSUA 1ELZA 3M8ZA 4MHXA 5EGHA 4CXSA 1ELXA 2W5TA 3BDHA 5LRMA 1EJJA 1URAA 3MK2A 1EW8A 4GTYA 1SHQA 2IFYA 3NKOA 3IGYB 3BDFA 4N7TA 1ELYA 1KHNA 4LRFA 5DLVA 1KHKA 4LRCA 4CXKA 5C66A 1KHJA 1KHLA 2W8DA 3UN2A 3M8YA 2GSOA 3WAVA 5LRNA 2ZKTA 3A52A 5K4PA 3LXQA 5DLWA 1HJKA 1ALHA 3SZYA 1KH5A 3TWZA 1EQJA 4KAYA 4KJGA 4LRAA 3NKQA 5L0EA 3KD8A 5LQQA 1ALIA 5L0KA 1URBA 4LRBA 2RH6A 5GOVA
chains in the Genus database with same CATH topology
1ZEBA 1KH7A 1O99A 3WAWA 1ANJA 1AJAA 1ZEDA 2IUCA 4KM4A 3UNYA 3NVLA 3T02A 2W5WA 4LR8A 1Y7AA 4UPLA 5AJ9A 4CYSA 1E1ZP 5DLTA 3IDDA 2W5SA 2XR9A 3CMRA 5TJ3A 2ANHA 1HDHA 1KH4A 1ZEFA 4ZG6A 3MK0A 3WAXA 4FDIA 1K7HA 1O98A 4LRDA 3UN5A 1N2KA 2G9YA 4NWJA 3NKRA 3DPCA 4FDJA 4QAXA 3UN3A 1P49A 2XRGA 3NKPA 3OT9A 2D1GA 3BDGB 4UPKA 3TX0A 1ALJA 3MK1A 4TN0A 3B5QA 4LR9A 1E3CP 3ED4A 1AUKA 3IGZB 5IJQA 4UPIA 3NKMA 4MIVA 4UOPA 3UO0A 5GRRA 5HRTA 1AJBA 3E2DA 4NWXA 4CYRA 4B56A 1E33P 1EI6A 3M8WA 4LREA 4KJDA 2GA3A 3WBHA 1ED9A 3Q3QA 1SHNA 1B8JA 5EGEA 4LR7A 4ZG9A 2W8SA 1HQAA 2GLQA 3NKNA 4CXUA 2W5QA 1AJCA 1ED8A 2W5RA 3M7VA 3T00A 2QZUA 2X98A 1EW2A 4UPHA 1ALKA 5KXAA 4GTZA 4GTWA 4ZG7A 1KH9A 4MY4A 2GSUA 1E2SP 3DYCA 1ANIA 5L0BA 4ZGAA 5IJSA 2W5VA 3WAYA 1EW9A 4UOOA 4UORA 2IUCB 3SZZA 1N2LA 2GSNA 3BDGA 2W5XA 1AJDA 5INHA 5LIAA 2VQRA 4GTXA 3TG0A 4KAVA 1Y6VA 4LQYA 4LR2A 4YR1A 3T01A 1FSUA 1ELZA 3M8ZA 4MHXA 5EGHA 4CXSA 1ELXA 2W5TA 3BDHA 5LRMA 1EJJA 1URAA 3MK2A 1EW8A 4GTYA 1SHQA 2IFYA 3NKOA 3IGYB 3BDFA 4N7TA 1ELYA 1KHNA 4LRFA 5DLVA 1KHKA 4LRCA 4CXKA 5C66A 1KHJA 1KHLA 2W8DA 3UN2A 3M8YA 2GSOA 3WAVA 5LRNA 2ZKTA 3A52A 5K4PA 3LXQA 5DLWA 1HJKA 1ALHA 3SZYA 1KH5A 3TWZA 1EQJA 4KAYA 4KJGA 4LRAA 3NKQA 5L0EA 3KD8A 5LQQA 1ALIA 5L0KA 1URBA 4LRBA 2RH6A 5GOVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZEB A;  1KH7 A;  1O99 A;  3WAW A;  1ANJ A;  1AJA A;  1ZED A;  2IUC A;  4KM4 A;  3UNY A;  3NVL A;  3T02 A;  2W5W A;  4LR8 A;  1Y7A A;  4UPL A;  5AJ9 A;  4CYS A;  1E1Z P;  5DLT A;  3IDD A;  2W5S A;  2XR9 A;  3CMR A;  5TJ3 A;  2ANH A;  1HDH A;  1KH4 A;  1ZEF A;  4ZG6 A;  3MK0 A;  3WAX A;  4FDI A;  1K7H A;  1O98 A;  4LRD A;  3UN5 A;  1N2K A;  2G9Y A;  4NWJ A;  3NKR A;  3DPC A;  4FDJ A;  4QAX A;  3UN3 A;  1P49 A;  2XRG A;  3NKP A;  3OT9 A;  2D1G A;  3BDG B;  4UPK A;  3TX0 A;  1ALJ A;  3MK1 A;  4TN0 A;  3B5Q A;  4LR9 A;  1E3C P;  3ED4 A;  1AUK A;  3IGZ B;  5IJQ A;  4UPI A;  3NKM A;  4MIV A;  4UOP A;  3UO0 A;  5GRR A;  5HRT A;  1AJB A;  3E2D A;  4NWX A;  4CYR A;  4B56 A;  1E33 P;  1EI6 A;  3M8W A;  4LRE A;  4KJD A;  2GA3 A;  3WBH A;  1ED9 A;  3Q3Q A;  1SHN A;  1B8J A;  5EGE A;  4LR7 A;  4ZG9 A;  2W8S A;  1HQA A;  2GLQ A;  3NKN A;  4CXU A;  2W5Q A;  1AJC A;  1ED8 A;  2W5R A;  3M7V A;  3T00 A;  2QZU A;  2X98 A;  1EW2 A;  4UPH A;  1ALK A;  5KXA A;  4GTZ A;  4GTW A;  4ZG7 A;  1KH9 A;  4MY4 A;  2GSU A;  1E2S P;  3DYC A;  1ANI A;  5L0B A;  4ZGA A;  5IJS A;  2W5V A;  3WAY A;  1EW9 A;  4UOO A;  4UOR A;  2IUC B;  3SZZ A;  1N2L A;  2GSN A;  3BDG A;  2W5X A;  1AJD A;  5INH A;  5LIA A;  2VQR A;  4GTX A;  3TG0 A;  4KAV A;  1Y6V A;  4LQY A;  4LR2 A;  4YR1 A;  3T01 A;  1FSU A;  1ELZ A;  3M8Z A;  4MHX A;  5EGH A;  4CXS A;  1ELX A;  2W5T A;  3BDH A;  5LRM A;  1EJJ A;  1URA A;  3MK2 A;  1EW8 A;  4GTY A;  1SHQ A;  2IFY A;  3NKO A;  3IGY B;  3BDF A;  4N7T A;  1ELY A;  1KHN A;  4LRF A;  5DLV A;  1KHK A;  4LRC A;  4CXK A;  5C66 A;  1KHJ A;  1KHL A;  2W8D A;  3UN2 A;  3M8Y A;  2GSO A;  3WAV A;  5LRN A;  2ZKT A;  3A52 A;  5K4P A;  3LXQ A;  5DLW A;  1HJK A;  1ALH A;  3SZY A;  1KH5 A;  3TWZ A;  1EQJ A;  4KAY A;  4KJG A;  4LRA A;  3NKQ A;  5L0E A;  3KD8 A;  5LQQ A;  1ALI A;  5L0K A;  1URB A;  4LRB A;  2RH6 A;  5GOV A; 
#chains in the Genus database with same CATH topology
 1ZEB A;  1KH7 A;  1O99 A;  3WAW A;  1ANJ A;  1AJA A;  1ZED A;  2IUC A;  4KM4 A;  3UNY A;  3NVL A;  3T02 A;  2W5W A;  4LR8 A;  1Y7A A;  4UPL A;  5AJ9 A;  4CYS A;  1E1Z P;  5DLT A;  3IDD A;  2W5S A;  2XR9 A;  3CMR A;  5TJ3 A;  2ANH A;  1HDH A;  1KH4 A;  1ZEF A;  4ZG6 A;  3MK0 A;  3WAX A;  4FDI A;  1K7H A;  1O98 A;  4LRD A;  3UN5 A;  1N2K A;  2G9Y A;  4NWJ A;  3NKR A;  3DPC A;  4FDJ A;  4QAX A;  3UN3 A;  1P49 A;  2XRG A;  3NKP A;  3OT9 A;  2D1G A;  3BDG B;  4UPK A;  3TX0 A;  1ALJ A;  3MK1 A;  4TN0 A;  3B5Q A;  4LR9 A;  1E3C P;  3ED4 A;  1AUK A;  3IGZ B;  5IJQ A;  4UPI A;  3NKM A;  4MIV A;  4UOP A;  3UO0 A;  5GRR A;  5HRT A;  1AJB A;  3E2D A;  4NWX A;  4CYR A;  4B56 A;  1E33 P;  1EI6 A;  3M8W A;  4LRE A;  4KJD A;  2GA3 A;  3WBH A;  1ED9 A;  3Q3Q A;  1SHN A;  1B8J A;  5EGE A;  4LR7 A;  4ZG9 A;  2W8S A;  1HQA A;  2GLQ A;  3NKN A;  4CXU A;  2W5Q A;  1AJC A;  1ED8 A;  2W5R A;  3M7V A;  3T00 A;  2QZU A;  2X98 A;  1EW2 A;  4UPH A;  1ALK A;  5KXA A;  4GTZ A;  4GTW A;  4ZG7 A;  1KH9 A;  4MY4 A;  2GSU A;  1E2S P;  3DYC A;  1ANI A;  5L0B A;  4ZGA A;  5IJS A;  2W5V A;  3WAY A;  1EW9 A;  4UOO A;  4UOR A;  2IUC B;  3SZZ A;  1N2L A;  2GSN A;  3BDG A;  2W5X A;  1AJD A;  5INH A;  5LIA A;  2VQR A;  4GTX A;  3TG0 A;  4KAV A;  1Y6V A;  4LQY A;  4LR2 A;  4YR1 A;  3T01 A;  1FSU A;  1ELZ A;  3M8Z A;  4MHX A;  5EGH A;  4CXS A;  1ELX A;  2W5T A;  3BDH A;  5LRM A;  1EJJ A;  1URA A;  3MK2 A;  1EW8 A;  4GTY A;  1SHQ A;  2IFY A;  3NKO A;  3IGY B;  3BDF A;  4N7T A;  1ELY A;  1KHN A;  4LRF A;  5DLV A;  1KHK A;  4LRC A;  4CXK A;  5C66 A;  1KHJ A;  1KHL A;  2W8D A;  3UN2 A;  3M8Y A;  2GSO A;  3WAV A;  5LRN A;  2ZKT A;  3A52 A;  5K4P A;  3LXQ A;  5DLW A;  1HJK A;  1ALH A;  3SZY A;  1KH5 A;  3TWZ A;  1EQJ A;  4KAY A;  4KJG A;  4LRA A;  3NKQ A;  5L0E A;  3KD8 A;  5LQQ A;  1ALI A;  5L0K A;  1URB A;  4LRB A;  2RH6 A;  5GOV A; 
#chains in the Genus database with same CATH homology
 1ZEB A;  1KH7 A;  1O99 A;  3WAW A;  1ANJ A;  1AJA A;  1ZED A;  2IUC A;  4KM4 A;  3UNY A;  3NVL A;  3T02 A;  2W5W A;  4LR8 A;  1Y7A A;  4UPL A;  5AJ9 A;  4CYS A;  1E1Z P;  5DLT A;  3IDD A;  2W5S A;  2XR9 A;  3CMR A;  5TJ3 A;  2ANH A;  1HDH A;  1KH4 A;  1ZEF A;  4ZG6 A;  3MK0 A;  3WAX A;  4FDI A;  1K7H A;  1O98 A;  4LRD A;  3UN5 A;  1N2K A;  2G9Y A;  4NWJ A;  3NKR A;  3DPC A;  4FDJ A;  4QAX A;  3UN3 A;  1P49 A;  2XRG A;  3NKP A;  3OT9 A;  2D1G A;  3BDG B;  4UPK A;  3TX0 A;  1ALJ A;  3MK1 A;  4TN0 A;  3B5Q A;  4LR9 A;  1E3C P;  3ED4 A;  1AUK A;  3IGZ B;  5IJQ A;  4UPI A;  3NKM A;  4MIV A;  4UOP A;  3UO0 A;  5GRR A;  5HRT A;  1AJB A;  3E2D A;  4NWX A;  4CYR A;  4B56 A;  1E33 P;  1EI6 A;  3M8W A;  4LRE A;  4KJD A;  2GA3 A;  3WBH A;  1ED9 A;  3Q3Q A;  1SHN A;  1B8J A;  5EGE A;  4LR7 A;  4ZG9 A;  2W8S A;  1HQA A;  2GLQ A;  3NKN A;  4CXU A;  2W5Q A;  1AJC A;  1ED8 A;  2W5R A;  3M7V A;  3T00 A;  2QZU A;  2X98 A;  1EW2 A;  4UPH A;  1ALK A;  5KXA A;  4GTZ A;  4GTW A;  4ZG7 A;  1KH9 A;  4MY4 A;  2GSU A;  1E2S P;  3DYC A;  1ANI A;  5L0B A;  4ZGA A;  5IJS A;  2W5V A;  3WAY A;  1EW9 A;  4UOO A;  4UOR A;  2IUC B;  3SZZ A;  1N2L A;  2GSN A;  3BDG A;  2W5X A;  1AJD A;  5INH A;  5LIA A;  2VQR A;  4GTX A;  3TG0 A;  4KAV A;  1Y6V A;  4LQY A;  4LR2 A;  4YR1 A;  3T01 A;  1FSU A;  1ELZ A;  3M8Z A;  4MHX A;  5EGH A;  4CXS A;  1ELX A;  2W5T A;  3BDH A;  5LRM A;  1EJJ A;  1URA A;  3MK2 A;  1EW8 A;  4GTY A;  1SHQ A;  2IFY A;  3NKO A;  3IGY B;  3BDF A;  4N7T A;  1ELY A;  1KHN A;  4LRF A;  5DLV A;  1KHK A;  4LRC A;  4CXK A;  5C66 A;  1KHJ A;  1KHL A;  2W8D A;  3UN2 A;  3M8Y A;  2GSO A;  3WAV A;  5LRN A;  2ZKT A;  3A52 A;  5K4P A;  3LXQ A;  5DLW A;  1HJK A;  1ALH A;  3SZY A;  1KH5 A;  3TWZ A;  1EQJ A;  4KAY A;  4KJG A;  4LRA A;  3NKQ A;  5L0E A;  3KD8 A;  5LQQ A;  1ALI A;  5L0K A;  1URB A;  4LRB A;  2RH6 A;  5GOV A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...