1YC0I

Short form hgfa with first kunitz domain from hai-1
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
66
structure length
66
Chain Sequence
QHQHQMHQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B.
pubmed doi rcsb
molecule tags Hydrolase/inhibitor
source organism Homo sapiens
molecule keywords Hepatocyte growth factor activator
total genus 13
structure length 66
sequence length 66
ec nomenclature
pdb deposition date 2004-12-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1yc0I00
1FANA 2FI3I 1B0CA 1JV8A 3BTTI 8PTIA 3AUDA 5JB4A 1BUNB 2ZJXA 2HEXA 4Y10I 1P2KI 1P2NB 1K6UA 1EAWB 4ISLB 1KNTA 3UOUB 1ADZA 4BQDA 1KIGI 6PTIA 1D0DA 1BHCA 1T8NB 1BF0A 9PTIA 1AALA 1UUAA 3AUCA 4PTIA 1BZXI 3FP7J 2PTCI 4DG4C 5PTIA 3LDMA 1T8MB 2CA7A 3AUIA 1KTHA 3BTMI 3LDJA 3FP8I 2R9PE 3CI7A 5C67C 3T62D 1DTXA 2KNTA 3OTJI 1JC6A 4BNRI 3WNYA 2UUXA 3BTWI 1ZR0B 3AUBA 1G6XA 1TFXC 3LDIA 1BRBI 1BZ5A 1CO7I 1OA55 3P92E 1LD6A 1YLCB 1CA0D 4U32X 1TOCR 2FTLI 3BTDI 1P2QB 4Y11I 3M7QB 4ISNB 1KUNA 1SHPA 2ODYE 4TPII 1T8OB 3BTFI 3AUEA 3L3TE 7PTIA 2FI5I 1PITA 3AUHA 2M01A 1LD5A 4DTGK 1BPIA 3BTHI 1CBWD 3GYMI 1FY8I 1BRCI 2J6DA 2W8XA 4NTXB 3TGKI 1BTIA 1YLDB 1TAWB 4BD9B 1IRHA 3AUGA 1NAGA 5JB5A 1MTND 1BIKA 1EJMB 1OA65 1BPTA 1T7CB 1UUBA 4Y0YI 3BTGI 3BTQI 1P2JI 3TGII 3UIRC 3BYBA 2KAII 4WXVC 1TCPA 2FI4I 1F5RI 2DDIA 5JB7A 2RA3C 3BTEI 4WWYC 1DTKA 3L33E 3TGJI 1P2II 3D65I 2DDJA 2TPII 4Y0ZI 4ISOB 3TPII 1YC0I 1BTHP 2ZVXA 2TGPI 2LFLA 4NTWB 1JV9A 1FAKI 1QLQA 1DEMA 2IJOI 2LFKA 1T8LB 1ZJDB 3P95E 2JOTA 2FTMB 1TAPA 2M99A 1AAPA 1TPAI 3OFWA 5JB6A 3FP6I 1P2MB 1DENA 3BTKI 1P2OB 3U1JE 4NTYB 4U30W 2KCRA 2UUYB 1Y62A 1YKTB 1D0DB 1F7ZI
chains in the Genus database with same CATH superfamily
1FANA 2FI3I 1B0CA 1JV8A 3BTTI 8PTIA 3AUDA 5JB4A 1BUNB 2ZJXA 2HEXA 4Y10I 1P2KI 1P2NB 1K6UA 1EAWB 4ISLB 1KNTA 3UOUB 1ADZA 4BQDA 1KIGI 6PTIA 1D0DA 1BHCA 1T8NB 1BF0A 9PTIA 1AALA 1UUAA 3AUCA 4PTIA 1BZXI 3FP7J 2PTCI 4DG4C 5PTIA 3LDMA 1T8MB 2CA7A 3AUIA 1KTHA 3BTMI 3LDJA 3FP8I 2R9PE 3CI7A 5C67C 3T62D 1DTXA 2KNTA 3OTJI 1JC6A 4BNRI 3WNYA 2UUXA 3BTWI 1ZR0B 3AUBA 1G6XA 1TFXC 3LDIA 1BRBI 1BZ5A 1CO7I 1OA55 3P92E 1LD6A 1YLCB 1CA0D 4U32X 1TOCR 2FTLI 3BTDI 1P2QB 4Y11I 3M7QB 4ISNB 1KUNA 1SHPA 2ODYE 4TPII 1T8OB 3BTFI 3AUEA 3L3TE 7PTIA 2FI5I 1PITA 3AUHA 2M01A 1LD5A 4DTGK 1BPIA 3BTHI 1CBWD 3GYMI 1FY8I 1BRCI 2J6DA 2W8XA 4NTXB 3TGKI 1BTIA 1YLDB 1TAWB 4BD9B 1IRHA 3AUGA 1NAGA 5JB5A 1MTND 1BIKA 1EJMB 1OA65 1BPTA 1T7CB 1UUBA 4Y0YI 3BTGI 3BTQI 1P2JI 3TGII 3UIRC 3BYBA 2KAII 4WXVC 1TCPA 2FI4I 1F5RI 2DDIA 5JB7A 2RA3C 3BTEI 4WWYC 1DTKA 3L33E 3TGJI 1P2II 3D65I 2DDJA 2TPII 4Y0ZI 4ISOB 3TPII 1YC0I 1BTHP 2ZVXA 2TGPI 2LFLA 4NTWB 1JV9A 1FAKI 1QLQA 1DEMA 2IJOI 2LFKA 1T8LB 1ZJDB 3P95E 2JOTA 2FTMB 1TAPA 2M99A 1AAPA 1TPAI 3OFWA 5JB6A 3FP6I 1P2MB 1DENA 3BTKI 1P2OB 3U1JE 4NTYB 4U30W 2KCRA 2UUYB 1Y62A 1YKTB 1D0DB 1F7ZI
chains in the Genus database with same CATH topology
1FANA 2FI3I 1B0CA 1JV8A 3BTTI 8PTIA 3AUDA 5JB4A 1BUNB 2ZJXA 2HEXA 4Y10I 1P2KI 1P2NB 1K6UA 1EAWB 4ISLB 1KNTA 3UOUB 1ADZA 4BQDA 1KIGI 6PTIA 1D0DA 1BHCA 1T8NB 1BF0A 9PTIA 1AALA 1UUAA 3AUCA 4PTIA 1BZXI 3FP7J 2PTCI 4DG4C 5PTIA 3LDMA 1T8MB 2CA7A 3AUIA 1KTHA 3BTMI 3LDJA 3FP8I 2R9PE 3CI7A 5C67C 3T62D 1DTXA 2KNTA 3OTJI 1JC6A 4BNRI 3WNYA 2UUXA 3BTWI 1ZR0B 3AUBA 1G6XA 1TFXC 3LDIA 1BRBI 1BZ5A 1CO7I 1OA55 3P92E 1LD6A 1YLCB 1CA0D 4U32X 1TOCR 2FTLI 3BTDI 1P2QB 4Y11I 3M7QB 4ISNB 1KUNA 1SHPA 2ODYE 4TPII 1T8OB 3BTFI 3AUEA 3L3TE 7PTIA 2FI5I 1PITA 3AUHA 2M01A 1LD5A 4DTGK 1BPIA 3BTHI 1CBWD 3GYMI 1FY8I 1BRCI 2J6DA 2W8XA 4NTXB 3TGKI 1BTIA 1YLDB 1TAWB 4BD9B 1IRHA 3AUGA 1NAGA 5JB5A 1MTND 1BIKA 1EJMB 1OA65 1BPTA 1T7CB 1UUBA 4Y0YI 3BTGI 3BTQI 1P2JI 3TGII 3UIRC 3BYBA 2KAII 4WXVC 1TCPA 2FI4I 1F5RI 2DDIA 5JB7A 2RA3C 3BTEI 4WWYC 1DTKA 3L33E 3TGJI 1P2II 3D65I 2DDJA 2TPII 4Y0ZI 4ISOB 3TPII 1YC0I 1BTHP 2ZVXA 2TGPI 2LFLA 4NTWB 1JV9A 1FAKI 1QLQA 1DEMA 2IJOI 2LFKA 1T8LB 1ZJDB 3P95E 2JOTA 2FTMB 1TAPA 2M99A 1AAPA 1TPAI 3OFWA 5JB6A 3FP6I 1P2MB 1DENA 3BTKI 1P2OB 3U1JE 4NTYB 4U30W 2KCRA 2UUYB 1Y62A 1YKTB 1D0DB 1F7ZI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FAN A;  2FI3 I;  1B0C A;  1JV8 A;  3BTT I;  8PTI A;  3AUD A;  5JB4 A;  1BUN B;  2ZJX A;  2HEX A;  4Y10 I;  1P2K I;  1P2N B;  1K6U A;  1EAW B;  4ISL B;  1KNT A;  3UOU B;  1ADZ A;  4BQD A;  1KIG I;  6PTI A;  1D0D A;  1BHC A;  1T8N B;  1BF0 A;  9PTI A;  1AAL A;  1UUA A;  3AUC A;  4PTI A;  1BZX I;  3FP7 J;  2PTC I;  4DG4 C;  5PTI A;  3LDM A;  1T8M B;  2CA7 A;  3AUI A;  1KTH A;  3BTM I;  3LDJ A;  3FP8 I;  2R9P E;  3CI7 A;  5C67 C;  3T62 D;  1DTX A;  2KNT A;  3OTJ I;  1JC6 A;  4BNR I;  3WNY A;  2UUX A;  3BTW I;  1ZR0 B;  3AUB A;  1G6X A;  1TFX C;  3LDI A;  1BRB I;  1BZ5 A;  1CO7 I;  1OA5 5;  3P92 E;  1LD6 A;  1YLC B;  1CA0 D;  4U32 X;  1TOC R;  2FTL I;  3BTD I;  1P2Q B;  4Y11 I;  3M7Q B;  4ISN B;  1KUN A;  1SHP A;  2ODY E;  4TPI I;  1T8O B;  3BTF I;  3AUE A;  3L3T E;  7PTI A;  2FI5 I;  1PIT A;  3AUH A;  2M01 A;  1LD5 A;  4DTG K;  1BPI A;  3BTH I;  1CBW D;  3GYM I;  1FY8 I;  1BRC I;  2J6D A;  2W8X A;  4NTX B;  3TGK I;  1BTI A;  1YLD B;  1TAW B;  4BD9 B;  1IRH A;  3AUG A;  1NAG A;  5JB5 A;  1MTN D;  1BIK A;  1EJM B;  1OA6 5;  1BPT A;  1T7C B;  1UUB A;  4Y0Y I;  3BTG I;  3BTQ I;  1P2J I;  3TGI I;  3UIR C;  3BYB A;  2KAI I;  4WXV C;  1TCP A;  2FI4 I;  1F5R I;  2DDI A;  5JB7 A;  2RA3 C;  3BTE I;  4WWY C;  1DTK A;  3L33 E;  3TGJ I;  1P2I I;  3D65 I;  2DDJ A;  2TPI I;  4Y0Z I;  4ISO B;  3TPI I;  1YC0 I;  1BTH P;  2ZVX A;  2TGP I;  2LFL A;  4NTW B;  1JV9 A;  1FAK I;  1QLQ A;  1DEM A;  2IJO I;  2LFK A;  1T8L B;  1ZJD B;  3P95 E;  2JOT A;  2FTM B;  1TAP A;  2M99 A;  1AAP A;  1TPA I;  3OFW A;  5JB6 A;  3FP6 I;  1P2M B;  1DEN A;  3BTK I;  1P2O B;  3U1J E;  4NTY B;  4U30 W;  2KCR A;  2UUY B;  1Y62 A;  1YKT B;  1D0D B;  1F7Z I; 
#chains in the Genus database with same CATH topology
 1FAN A;  2FI3 I;  1B0C A;  1JV8 A;  3BTT I;  8PTI A;  3AUD A;  5JB4 A;  1BUN B;  2ZJX A;  2HEX A;  4Y10 I;  1P2K I;  1P2N B;  1K6U A;  1EAW B;  4ISL B;  1KNT A;  3UOU B;  1ADZ A;  4BQD A;  1KIG I;  6PTI A;  1D0D A;  1BHC A;  1T8N B;  1BF0 A;  9PTI A;  1AAL A;  1UUA A;  3AUC A;  4PTI A;  1BZX I;  3FP7 J;  2PTC I;  4DG4 C;  5PTI A;  3LDM A;  1T8M B;  2CA7 A;  3AUI A;  1KTH A;  3BTM I;  3LDJ A;  3FP8 I;  2R9P E;  3CI7 A;  5C67 C;  3T62 D;  1DTX A;  2KNT A;  3OTJ I;  1JC6 A;  4BNR I;  3WNY A;  2UUX A;  3BTW I;  1ZR0 B;  3AUB A;  1G6X A;  1TFX C;  3LDI A;  1BRB I;  1BZ5 A;  1CO7 I;  1OA5 5;  3P92 E;  1LD6 A;  1YLC B;  1CA0 D;  4U32 X;  1TOC R;  2FTL I;  3BTD I;  1P2Q B;  4Y11 I;  3M7Q B;  4ISN B;  1KUN A;  1SHP A;  2ODY E;  4TPI I;  1T8O B;  3BTF I;  3AUE A;  3L3T E;  7PTI A;  2FI5 I;  1PIT A;  3AUH A;  2M01 A;  1LD5 A;  4DTG K;  1BPI A;  3BTH I;  1CBW D;  3GYM I;  1FY8 I;  1BRC I;  2J6D A;  2W8X A;  4NTX B;  3TGK I;  1BTI A;  1YLD B;  1TAW B;  4BD9 B;  1IRH A;  3AUG A;  1NAG A;  5JB5 A;  1MTN D;  1BIK A;  1EJM B;  1OA6 5;  1BPT A;  1T7C B;  1UUB A;  4Y0Y I;  3BTG I;  3BTQ I;  1P2J I;  3TGI I;  3UIR C;  3BYB A;  2KAI I;  4WXV C;  1TCP A;  2FI4 I;  1F5R I;  2DDI A;  5JB7 A;  2RA3 C;  3BTE I;  4WWY C;  1DTK A;  3L33 E;  3TGJ I;  1P2I I;  3D65 I;  2DDJ A;  2TPI I;  4Y0Z I;  4ISO B;  3TPI I;  1YC0 I;  1BTH P;  2ZVX A;  2TGP I;  2LFL A;  4NTW B;  1JV9 A;  1FAK I;  1QLQ A;  1DEM A;  2IJO I;  2LFK A;  1T8L B;  1ZJD B;  3P95 E;  2JOT A;  2FTM B;  1TAP A;  2M99 A;  1AAP A;  1TPA I;  3OFW A;  5JB6 A;  3FP6 I;  1P2M B;  1DEN A;  3BTK I;  1P2O B;  3U1J E;  4NTY B;  4U30 W;  2KCR A;  2UUY B;  1Y62 A;  1YKT B;  1D0D B;  1F7Z I; 
#chains in the Genus database with same CATH homology
 1FAN A;  2FI3 I;  1B0C A;  1JV8 A;  3BTT I;  8PTI A;  3AUD A;  5JB4 A;  1BUN B;  2ZJX A;  2HEX A;  4Y10 I;  1P2K I;  1P2N B;  1K6U A;  1EAW B;  4ISL B;  1KNT A;  3UOU B;  1ADZ A;  4BQD A;  1KIG I;  6PTI A;  1D0D A;  1BHC A;  1T8N B;  1BF0 A;  9PTI A;  1AAL A;  1UUA A;  3AUC A;  4PTI A;  1BZX I;  3FP7 J;  2PTC I;  4DG4 C;  5PTI A;  3LDM A;  1T8M B;  2CA7 A;  3AUI A;  1KTH A;  3BTM I;  3LDJ A;  3FP8 I;  2R9P E;  3CI7 A;  5C67 C;  3T62 D;  1DTX A;  2KNT A;  3OTJ I;  1JC6 A;  4BNR I;  3WNY A;  2UUX A;  3BTW I;  1ZR0 B;  3AUB A;  1G6X A;  1TFX C;  3LDI A;  1BRB I;  1BZ5 A;  1CO7 I;  1OA5 5;  3P92 E;  1LD6 A;  1YLC B;  1CA0 D;  4U32 X;  1TOC R;  2FTL I;  3BTD I;  1P2Q B;  4Y11 I;  3M7Q B;  4ISN B;  1KUN A;  1SHP A;  2ODY E;  4TPI I;  1T8O B;  3BTF I;  3AUE A;  3L3T E;  7PTI A;  2FI5 I;  1PIT A;  3AUH A;  2M01 A;  1LD5 A;  4DTG K;  1BPI A;  3BTH I;  1CBW D;  3GYM I;  1FY8 I;  1BRC I;  2J6D A;  2W8X A;  4NTX B;  3TGK I;  1BTI A;  1YLD B;  1TAW B;  4BD9 B;  1IRH A;  3AUG A;  1NAG A;  5JB5 A;  1MTN D;  1BIK A;  1EJM B;  1OA6 5;  1BPT A;  1T7C B;  1UUB A;  4Y0Y I;  3BTG I;  3BTQ I;  1P2J I;  3TGI I;  3UIR C;  3BYB A;  2KAI I;  4WXV C;  1TCP A;  2FI4 I;  1F5R I;  2DDI A;  5JB7 A;  2RA3 C;  3BTE I;  4WWY C;  1DTK A;  3L33 E;  3TGJ I;  1P2I I;  3D65 I;  2DDJ A;  2TPI I;  4Y0Z I;  4ISO B;  3TPI I;  1YC0 I;  1BTH P;  2ZVX A;  2TGP I;  2LFL A;  4NTW B;  1JV9 A;  1FAK I;  1QLQ A;  1DEM A;  2IJO I;  2LFK A;  1T8L B;  1ZJD B;  3P95 E;  2JOT A;  2FTM B;  1TAP A;  2M99 A;  1AAP A;  1TPA I;  3OFW A;  5JB6 A;  3FP6 I;  1P2M B;  1DEN A;  3BTK I;  1P2O B;  3U1J E;  4NTY B;  4U30 W;  2KCR A;  2UUY B;  1Y62 A;  1YKT B;  1D0D B;  1F7Z I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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