1ZEBA

X-ray structure of alkaline phosphatase from human placenta in complex with 5'-amp
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
Knots found
sequence length
480
structure length
479
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
total genus 173
structure length 479
sequence length 480
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zebA00
1ELZA 4UOPA 3SZYA 1KH4A 4CYRA 3ED4A 3T01A 2W5WA 3M8YA 3NKNA 4GTZA 3B5QA 5EGHA 4YR1A 4UOOA 3NKRA 4NWJA 5LRNA 3Q3QA 5DLVA 3WAYA 3TG0A 3WAXA 2G9YA 4N7TA 1O98A 3NKPA 1ZEDA 3MK1A 4QAXA 4TN0A 2RH6A 3KD8A 2XRGA 1E1ZP 5TJ3A 2D1GA 4ZG6A 4CXSA 5HRTA 3NKOA 1E2SP 1ANIA 1HDHA 2GA3A 1URAA 3OT9A 2IUCA 2W5SA 1AJBA 1E33P 4KJDA 1EI6A 1AUKA 1EW2A 4LRCA 1EW9A 1AJDA 3A52A 4UPIA 4LRBA 1ALJA 2W5TA 3BDHA 4GTYA 1AJCA 1ANJA 2GSOA 5DLWA 1KH9A 4LR9A 4CXKA 1KHLA 5LQQA 2W5RA 3LXQA 4CXUA 1K7HA 1N2LA 1SHQA 3WBHA 4B56A 5L0EA 1O99A 3M8WA 4FDIA 1E3CP 3BDGB 3MK0A 1ED9A 1HJKA 5L0KA 4LRFA 3NVLA 5IJQA 2IFYA 3DYCA 4GTWA 2XR9A 4GTXA 2VQRA 5K4PA 3MK2A 1ALIA 2W8SA 1ELYA 3IDDA 5GRRA 2W5XA 3TWZA 4LR7A 4MY4A 2W8DA 4MHXA 5EGEA 1ALHA 5IJSA 3NKMA 1ZEBA 5INHA 5KXAA 1AJAA 5DLTA 4LR2A 5C66A 4UORA 1KHJA 3UN2A 3UN5A 4MIVA 2IUCB 1HQAA 3NKQA 5LRMA 1ZEFA 3UN3A 3SZZA 3T00A 1FSUA 4NWXA 4ZG9A 1N2KA 1ELXA 1KHKA 3E2DA 1KH5A 2GSNA 4UPHA 2W5VA 2X98A 2GSUA 1ALKA 3TX0A 1ED8A 2ZKTA 4LR8A 4UPKA 4ZG7A 5LIAA 4UPLA 3WAWA 3BDFA 3DPCA 4LREA 1URBA 4KAYA 1EQJA 3M8ZA 4KAVA 1B8JA 2GLQA 4ZGAA 3T02A 3UO0A 1KHNA 5GOVA 1EW8A 3BDGA 3IGZB 2QZUA 1EJJA 5L0BA 3IGYB 1Y7AA 4KJGA 4KM4A 2W5QA 1P49A 4LRAA 2ANHA 3CMRA 3M7VA 4LRDA 1Y6VA 4CYSA 1SHNA 5AJ9A 3UNYA 3WAVA 4FDJA 1KH7A 4LQYA
chains in the Genus database with same CATH superfamily
1ELZA 4UOPA 3SZYA 1KH4A 4CYRA 3ED4A 3T01A 2W5WA 3M8YA 3NKNA 4GTZA 3B5QA 5EGHA 4YR1A 4UOOA 3NKRA 4NWJA 5LRNA 3Q3QA 5DLVA 3WAYA 3TG0A 3WAXA 2G9YA 4N7TA 1O98A 3NKPA 1ZEDA 3MK1A 4QAXA 4TN0A 2RH6A 3KD8A 2XRGA 1E1ZP 5TJ3A 2D1GA 4ZG6A 4CXSA 5HRTA 3NKOA 1E2SP 1ANIA 1HDHA 2GA3A 1URAA 3OT9A 2IUCA 2W5SA 1AJBA 1E33P 4KJDA 1EI6A 1AUKA 1EW2A 4LRCA 1EW9A 1AJDA 3A52A 4UPIA 4LRBA 1ALJA 2W5TA 3BDHA 4GTYA 1AJCA 1ANJA 2GSOA 5DLWA 1KH9A 4LR9A 4CXKA 1KHLA 5LQQA 2W5RA 3LXQA 4CXUA 1K7HA 1N2LA 1SHQA 3WBHA 4B56A 5L0EA 1O99A 3M8WA 4FDIA 1E3CP 3BDGB 3MK0A 1ED9A 1HJKA 5L0KA 4LRFA 3NVLA 5IJQA 2IFYA 3DYCA 4GTWA 2XR9A 4GTXA 2VQRA 5K4PA 3MK2A 1ALIA 2W8SA 1ELYA 3IDDA 5GRRA 2W5XA 3TWZA 4LR7A 4MY4A 2W8DA 4MHXA 5EGEA 1ALHA 5IJSA 3NKMA 1ZEBA 5INHA 5KXAA 1AJAA 5DLTA 4LR2A 5C66A 4UORA 1KHJA 3UN2A 3UN5A 4MIVA 2IUCB 1HQAA 3NKQA 5LRMA 1ZEFA 3UN3A 3SZZA 3T00A 1FSUA 4NWXA 4ZG9A 1N2KA 1ELXA 1KHKA 3E2DA 1KH5A 2GSNA 4UPHA 2W5VA 2X98A 2GSUA 1ALKA 3TX0A 1ED8A 2ZKTA 4LR8A 4UPKA 4ZG7A 5LIAA 4UPLA 3WAWA 3BDFA 3DPCA 4LREA 1URBA 4KAYA 1EQJA 3M8ZA 4KAVA 1B8JA 2GLQA 4ZGAA 3T02A 3UO0A 1KHNA 5GOVA 1EW8A 3BDGA 3IGZB 2QZUA 1EJJA 5L0BA 3IGYB 1Y7AA 4KJGA 4KM4A 2W5QA 1P49A 4LRAA 2ANHA 3CMRA 3M7VA 4LRDA 1Y6VA 4CYSA 1SHNA 5AJ9A 3UNYA 3WAVA 4FDJA 1KH7A 4LQYA
chains in the Genus database with same CATH topology
1ELZA 4UOPA 3SZYA 1KH4A 4CYRA 3ED4A 3T01A 2W5WA 3M8YA 3NKNA 4GTZA 3B5QA 5EGHA 4YR1A 4UOOA 3NKRA 4NWJA 5LRNA 3Q3QA 5DLVA 3WAYA 3TG0A 3WAXA 2G9YA 4N7TA 1O98A 3NKPA 1ZEDA 3MK1A 4QAXA 4TN0A 2RH6A 3KD8A 2XRGA 1E1ZP 5TJ3A 2D1GA 4ZG6A 4CXSA 5HRTA 3NKOA 1E2SP 1ANIA 1HDHA 2GA3A 1URAA 3OT9A 2IUCA 2W5SA 1AJBA 1E33P 4KJDA 1EI6A 1AUKA 1EW2A 4LRCA 1EW9A 1AJDA 3A52A 4UPIA 4LRBA 1ALJA 2W5TA 3BDHA 4GTYA 1AJCA 1ANJA 2GSOA 5DLWA 1KH9A 4LR9A 4CXKA 1KHLA 5LQQA 2W5RA 3LXQA 4CXUA 1K7HA 1N2LA 1SHQA 3WBHA 4B56A 5L0EA 1O99A 3M8WA 4FDIA 1E3CP 3BDGB 3MK0A 1ED9A 1HJKA 5L0KA 4LRFA 3NVLA 5IJQA 2IFYA 3DYCA 4GTWA 2XR9A 4GTXA 2VQRA 5K4PA 3MK2A 1ALIA 2W8SA 1ELYA 3IDDA 5GRRA 2W5XA 3TWZA 4LR7A 4MY4A 2W8DA 4MHXA 5EGEA 1ALHA 5IJSA 3NKMA 1ZEBA 5INHA 5KXAA 1AJAA 5DLTA 4LR2A 5C66A 4UORA 1KHJA 3UN2A 3UN5A 4MIVA 2IUCB 1HQAA 3NKQA 5LRMA 1ZEFA 3UN3A 3SZZA 3T00A 1FSUA 4NWXA 4ZG9A 1N2KA 1ELXA 1KHKA 3E2DA 1KH5A 2GSNA 4UPHA 2W5VA 2X98A 2GSUA 1ALKA 3TX0A 1ED8A 2ZKTA 4LR8A 4UPKA 4ZG7A 5LIAA 4UPLA 3WAWA 3BDFA 3DPCA 4LREA 1URBA 4KAYA 1EQJA 3M8ZA 4KAVA 1B8JA 2GLQA 4ZGAA 3T02A 3UO0A 1KHNA 5GOVA 1EW8A 3BDGA 3IGZB 2QZUA 1EJJA 5L0BA 3IGYB 1Y7AA 4KJGA 4KM4A 2W5QA 1P49A 4LRAA 2ANHA 3CMRA 3M7VA 4LRDA 1Y6VA 4CYSA 1SHNA 5AJ9A 3UNYA 3WAVA 4FDJA 1KH7A 4LQYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ELZ A;  4UOP A;  3SZY A;  1KH4 A;  4CYR A;  3ED4 A;  3T01 A;  2W5W A;  3M8Y A;  3NKN A;  4GTZ A;  3B5Q A;  5EGH A;  4YR1 A;  4UOO A;  3NKR A;  4NWJ A;  5LRN A;  3Q3Q A;  5DLV A;  3WAY A;  3TG0 A;  3WAX A;  2G9Y A;  4N7T A;  1O98 A;  3NKP A;  1ZED A;  3MK1 A;  4QAX A;  4TN0 A;  2RH6 A;  3KD8 A;  2XRG A;  1E1Z P;  5TJ3 A;  2D1G A;  4ZG6 A;  4CXS A;  5HRT A;  3NKO A;  1E2S P;  1ANI A;  1HDH A;  2GA3 A;  1URA A;  3OT9 A;  2IUC A;  2W5S A;  1AJB A;  1E33 P;  4KJD A;  1EI6 A;  1AUK A;  1EW2 A;  4LRC A;  1EW9 A;  1AJD A;  3A52 A;  4UPI A;  4LRB A;  1ALJ A;  2W5T A;  3BDH A;  4GTY A;  1AJC A;  1ANJ A;  2GSO A;  5DLW A;  1KH9 A;  4LR9 A;  4CXK A;  1KHL A;  5LQQ A;  2W5R A;  3LXQ A;  4CXU A;  1K7H A;  1N2L A;  1SHQ A;  3WBH A;  4B56 A;  5L0E A;  1O99 A;  3M8W A;  4FDI A;  1E3C P;  3BDG B;  3MK0 A;  1ED9 A;  1HJK A;  5L0K A;  4LRF A;  3NVL A;  5IJQ A;  2IFY A;  3DYC A;  4GTW A;  2XR9 A;  4GTX A;  2VQR A;  5K4P A;  3MK2 A;  1ALI A;  2W8S A;  1ELY A;  3IDD A;  5GRR A;  2W5X A;  3TWZ A;  4LR7 A;  4MY4 A;  2W8D A;  4MHX A;  5EGE A;  1ALH A;  5IJS A;  3NKM A;  1ZEB A;  5INH A;  5KXA A;  1AJA A;  5DLT A;  4LR2 A;  5C66 A;  4UOR A;  1KHJ A;  3UN2 A;  3UN5 A;  4MIV A;  2IUC B;  1HQA A;  3NKQ A;  5LRM A;  1ZEF A;  3UN3 A;  3SZZ A;  3T00 A;  1FSU A;  4NWX A;  4ZG9 A;  1N2K A;  1ELX A;  1KHK A;  3E2D A;  1KH5 A;  2GSN A;  4UPH A;  2W5V A;  2X98 A;  2GSU A;  1ALK A;  3TX0 A;  1ED8 A;  2ZKT A;  4LR8 A;  4UPK A;  4ZG7 A;  5LIA A;  4UPL A;  3WAW A;  3BDF A;  3DPC A;  4LRE A;  1URB A;  4KAY A;  1EQJ A;  3M8Z A;  4KAV A;  1B8J A;  2GLQ A;  4ZGA A;  3T02 A;  3UO0 A;  1KHN A;  5GOV A;  1EW8 A;  3BDG A;  3IGZ B;  2QZU A;  1EJJ A;  5L0B A;  3IGY B;  1Y7A A;  4KJG A;  4KM4 A;  2W5Q A;  1P49 A;  4LRA A;  2ANH A;  3CMR A;  3M7V A;  4LRD A;  1Y6V A;  4CYS A;  1SHN A;  5AJ9 A;  3UNY A;  3WAV A;  4FDJ A;  1KH7 A;  4LQY A; 
#chains in the Genus database with same CATH topology
 1ELZ A;  4UOP A;  3SZY A;  1KH4 A;  4CYR A;  3ED4 A;  3T01 A;  2W5W A;  3M8Y A;  3NKN A;  4GTZ A;  3B5Q A;  5EGH A;  4YR1 A;  4UOO A;  3NKR A;  4NWJ A;  5LRN A;  3Q3Q A;  5DLV A;  3WAY A;  3TG0 A;  3WAX A;  2G9Y A;  4N7T A;  1O98 A;  3NKP A;  1ZED A;  3MK1 A;  4QAX A;  4TN0 A;  2RH6 A;  3KD8 A;  2XRG A;  1E1Z P;  5TJ3 A;  2D1G A;  4ZG6 A;  4CXS A;  5HRT A;  3NKO A;  1E2S P;  1ANI A;  1HDH A;  2GA3 A;  1URA A;  3OT9 A;  2IUC A;  2W5S A;  1AJB A;  1E33 P;  4KJD A;  1EI6 A;  1AUK A;  1EW2 A;  4LRC A;  1EW9 A;  1AJD A;  3A52 A;  4UPI A;  4LRB A;  1ALJ A;  2W5T A;  3BDH A;  4GTY A;  1AJC A;  1ANJ A;  2GSO A;  5DLW A;  1KH9 A;  4LR9 A;  4CXK A;  1KHL A;  5LQQ A;  2W5R A;  3LXQ A;  4CXU A;  1K7H A;  1N2L A;  1SHQ A;  3WBH A;  4B56 A;  5L0E A;  1O99 A;  3M8W A;  4FDI A;  1E3C P;  3BDG B;  3MK0 A;  1ED9 A;  1HJK A;  5L0K A;  4LRF A;  3NVL A;  5IJQ A;  2IFY A;  3DYC A;  4GTW A;  2XR9 A;  4GTX A;  2VQR A;  5K4P A;  3MK2 A;  1ALI A;  2W8S A;  1ELY A;  3IDD A;  5GRR A;  2W5X A;  3TWZ A;  4LR7 A;  4MY4 A;  2W8D A;  4MHX A;  5EGE A;  1ALH A;  5IJS A;  3NKM A;  1ZEB A;  5INH A;  5KXA A;  1AJA A;  5DLT A;  4LR2 A;  5C66 A;  4UOR A;  1KHJ A;  3UN2 A;  3UN5 A;  4MIV A;  2IUC B;  1HQA A;  3NKQ A;  5LRM A;  1ZEF A;  3UN3 A;  3SZZ A;  3T00 A;  1FSU A;  4NWX A;  4ZG9 A;  1N2K A;  1ELX A;  1KHK A;  3E2D A;  1KH5 A;  2GSN A;  4UPH A;  2W5V A;  2X98 A;  2GSU A;  1ALK A;  3TX0 A;  1ED8 A;  2ZKT A;  4LR8 A;  4UPK A;  4ZG7 A;  5LIA A;  4UPL A;  3WAW A;  3BDF A;  3DPC A;  4LRE A;  1URB A;  4KAY A;  1EQJ A;  3M8Z A;  4KAV A;  1B8J A;  2GLQ A;  4ZGA A;  3T02 A;  3UO0 A;  1KHN A;  5GOV A;  1EW8 A;  3BDG A;  3IGZ B;  2QZU A;  1EJJ A;  5L0B A;  3IGY B;  1Y7A A;  4KJG A;  4KM4 A;  2W5Q A;  1P49 A;  4LRA A;  2ANH A;  3CMR A;  3M7V A;  4LRD A;  1Y6V A;  4CYS A;  1SHN A;  5AJ9 A;  3UNY A;  3WAV A;  4FDJ A;  1KH7 A;  4LQY A; 
#chains in the Genus database with same CATH homology
 1ELZ A;  4UOP A;  3SZY A;  1KH4 A;  4CYR A;  3ED4 A;  3T01 A;  2W5W A;  3M8Y A;  3NKN A;  4GTZ A;  3B5Q A;  5EGH A;  4YR1 A;  4UOO A;  3NKR A;  4NWJ A;  5LRN A;  3Q3Q A;  5DLV A;  3WAY A;  3TG0 A;  3WAX A;  2G9Y A;  4N7T A;  1O98 A;  3NKP A;  1ZED A;  3MK1 A;  4QAX A;  4TN0 A;  2RH6 A;  3KD8 A;  2XRG A;  1E1Z P;  5TJ3 A;  2D1G A;  4ZG6 A;  4CXS A;  5HRT A;  3NKO A;  1E2S P;  1ANI A;  1HDH A;  2GA3 A;  1URA A;  3OT9 A;  2IUC A;  2W5S A;  1AJB A;  1E33 P;  4KJD A;  1EI6 A;  1AUK A;  1EW2 A;  4LRC A;  1EW9 A;  1AJD A;  3A52 A;  4UPI A;  4LRB A;  1ALJ A;  2W5T A;  3BDH A;  4GTY A;  1AJC A;  1ANJ A;  2GSO A;  5DLW A;  1KH9 A;  4LR9 A;  4CXK A;  1KHL A;  5LQQ A;  2W5R A;  3LXQ A;  4CXU A;  1K7H A;  1N2L A;  1SHQ A;  3WBH A;  4B56 A;  5L0E A;  1O99 A;  3M8W A;  4FDI A;  1E3C P;  3BDG B;  3MK0 A;  1ED9 A;  1HJK A;  5L0K A;  4LRF A;  3NVL A;  5IJQ A;  2IFY A;  3DYC A;  4GTW A;  2XR9 A;  4GTX A;  2VQR A;  5K4P A;  3MK2 A;  1ALI A;  2W8S A;  1ELY A;  3IDD A;  5GRR A;  2W5X A;  3TWZ A;  4LR7 A;  4MY4 A;  2W8D A;  4MHX A;  5EGE A;  1ALH A;  5IJS A;  3NKM A;  1ZEB A;  5INH A;  5KXA A;  1AJA A;  5DLT A;  4LR2 A;  5C66 A;  4UOR A;  1KHJ A;  3UN2 A;  3UN5 A;  4MIV A;  2IUC B;  1HQA A;  3NKQ A;  5LRM A;  1ZEF A;  3UN3 A;  3SZZ A;  3T00 A;  1FSU A;  4NWX A;  4ZG9 A;  1N2K A;  1ELX A;  1KHK A;  3E2D A;  1KH5 A;  2GSN A;  4UPH A;  2W5V A;  2X98 A;  2GSU A;  1ALK A;  3TX0 A;  1ED8 A;  2ZKT A;  4LR8 A;  4UPK A;  4ZG7 A;  5LIA A;  4UPL A;  3WAW A;  3BDF A;  3DPC A;  4LRE A;  1URB A;  4KAY A;  1EQJ A;  3M8Z A;  4KAV A;  1B8J A;  2GLQ A;  4ZGA A;  3T02 A;  3UO0 A;  1KHN A;  5GOV A;  1EW8 A;  3BDG A;  3IGZ B;  2QZU A;  1EJJ A;  5L0B A;  3IGY B;  1Y7A A;  4KJG A;  4KM4 A;  2W5Q A;  1P49 A;  4LRA A;  2ANH A;  3CMR A;  3M7V A;  4LRD A;  1Y6V A;  4CYS A;  1SHN A;  5AJ9 A;  3UNY A;  3WAV A;  4FDJ A;  1KH7 A;  4LQY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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