2A9IA

Molecular structure of the interleukin-1 receptor-associated kinase-4 death domain
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
105
structure length
105
Chain Sequence
KPLTPSTYIRNLNVGILRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGLSPTCELLFDWGTTNCTVGDLVDLLVQIELFAPATLLLPDAVPQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Cutting Edge: Molecular Structure of the IL-1R-Associated Kinase-4 Death Domain and Its Implications for TLR Signaling.
pubmed rcsb
molecule tags Transferase
source organism Mus musculus
molecule keywords Interleukin-1 receptor-associated kinase-4
total genus 34
structure length 105
sequence length 105
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2005-07-11
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 2a9iA00
4F42A 4M9XA 2GF5A 2DBFA 3J63A 4P4HA 2NAQA 2G7RA 2D96A 1Z6TA 1YGOA 2N7ZA 4DWNA 1E41A 4IZ5E 2A5YB 1WXPA 2NSNA 4A2QA 4O9FA 1UCPA 2OF5H 4P4HI 2OF5A 2O71A 2N83A 3MOPA 2YVIA 4O6XA 2MN4A 2B1WA 4EWIA 3CL3A 2DO9A 2LWEA 1A1ZA 4O9LA 2L9MA 3LQRA 4D8OA 1D2ZB 4M9ZA 4F44A 1N3KA 3J6JA 3QF2A 2MS8A 4IZAB 2N00A 1PN5A 2KN6A 4N1KA 2DBDA 2MPCA 2VGQA 3CRDA 1NGRA 4ZBWA 1CWWA 2YU0A 2N1FA 4RHWE 1DGNA 2YQFA 1C15A 2LWDA 2DBHA 3MOPG 3MOPK 4LWDA 2BBRA 2LS7A 3LQQA 4RHWA 4N1LA 2A9IA 2P1HA 3EZQA 2MS7A 4I16A 4JQWA 2BBZA 2N97A 2L6AA 2KM6A 1ICHA 4QOBA 3KATA 2DBGA 4JUPA 2HM2Q 2NZ7A 2YGSA 1WH4A 3EZQB 2F1SA 2M5VA 4A2WA 4O7QA 4NQKA 1CY5A 1D2ZA 2N80A 1E3YA 1A1WA 2MB9A 4IZ7B 4M9SA 4FH0A 1FADA 4N1JA 4E9MA 2IB1A 3YGSC 3YGSP 4UZ0A 1DDFA 1WMGA 3T6PA
chains in the Genus database with same CATH superfamily
4F42A 4M9XA 2GF5A 2DBFA 3J63A 4P4HA 2NAQA 2G7RA 2D96A 1Z6TA 1YGOA 2N7ZA 4DWNA 1E41A 4IZ5E 2A5YB 1WXPA 2NSNA 2XV9A 4A2QA 4O9FA 1UCPA 2OF5H 4P4HI 2OF5A 2O71A 2N83A 3MOPA 2YVIA 4O6XA 2MN4A 2B1WA 4EWIA 3CL3A 2DO9A 2LWEA 1A1ZA 4O9LA 2L9MA 3LQRA 4D8OA 1D2ZB 4M9ZA 4F44A 1N3KA 3J6JA 3QF2A 2MS8A 4IZAB 2N00A 1PN5A 2KN6A 4N1KA 2DBDA 2MPCA 2VGQA 3CRDA 1NGRA 4ZBWA 1CWWA 2YU0A 2N1FA 4RHWE 1DGNA 2YQFA 1C15A 2LWDA 2DBHA 3MOPG 3MOPK 4LWDA 2BBRA 2LS7A 3LQQA 4RHWA 4N1LA 2A9IA 2P1HA 3EZQA 2MJMA 2MS7A 4I16A 4JQWA 2BBZA 2N97A 2L6AA 2KM6A 1ICHA 4QOBA 3KATA 2DBGA 4JUPA 2HM2Q 2NZ7A 2YGSA 1WH4A 3EZQB 2F1SA 2M5VA 4A2WA 4O7QA 4NQKA 1CY5A 1D2ZA 2N80A 1E3YA 1A1WA 2MB9A 4IZ7B 4M9SA 4FH0A 1FADA 4N1JA 4E9MA 2IB1A 3YGSC 3YGSP 4UZ0A 1DDFA 1WMGA 3T6PA
chains in the Genus database with same CATH topology
4F42A 4M9XA 2GF5A 2DBFA 3J63A 4P4HA 2NAQA 2G7RA 2D96A 1Z6TA 1YGOA 2N7ZA 4DWNA 1E41A 4IZ5E 2A5YB 1WXPA 2NSNA 2XV9A 4A2QA 4O9FA 1UCPA 2OF5H 4P4HI 2OF5A 2O71A 2N83A 3MOPA 2YVIA 4O6XA 2MN4A 2B1WA 4EWIA 3CL3A 2DO9A 2LWEA 1A1ZA 4O9LA 2L9MA 3LQRA 4D8OA 1D2ZB 4M9ZA 4F44A 1N3KA 3J6JA 3QF2A 2MS8A 4IZAB 2N00A 1PN5A 2KN6A 4N1KA 2DBDA 2MPCA 2VGQA 3CRDA 1NGRA 4ZBWA 1CWWA 2YU0A 2N1FA 4RHWE 1DGNA 2YQFA 1C15A 2LWDA 2DBHA 3MOPG 3MOPK 4LWDA 2BBRA 2LS7A 3LQQA 4RHWA 4N1LA 2A9IA 2P1HA 3EZQA 2MJMA 2MS7A 4I16A 4JQWA 2BBZA 2N97A 2L6AA 2KM6A 1ICHA 4QOBA 3KATA 2DBGA 4JUPA 2HM2Q 2NZ7A 2YGSA 1WH4A 3EZQB 2F1SA 2M5VA 4A2WA 4O7QA 4NQKA 1CY5A 1D2ZA 2N80A 1E3YA 1A1WA 2MB9A 4IZ7B 4M9SA 4FH0A 1FADA 4N1JA 4E9MA 2IB1A 3YGSC 3YGSP 4UZ0A 1DDFA 1WMGA 3T6PA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4F42 A;  4M9X A;  2GF5 A;  2DBF A;  3J63 A;  4P4H A;  2NAQ A;  2G7R A;  2D96 A;  1Z6T A;  1YGO A;  2N7Z A;  4DWN A;  1E41 A;  4IZ5 E;  2A5Y B;  1WXP A;  2NSN A;  4A2Q A;  4O9F A;  1UCP A;  2OF5 H;  4P4H I;  2OF5 A;  2O71 A;  2N83 A;  3MOP A;  2YVI A;  4O6X A;  2MN4 A;  2B1W A;  4EWI A;  3CL3 A;  2DO9 A;  2LWE A;  1A1Z A;  4O9L A;  2L9M A;  3LQR A;  4D8O A;  1D2Z B;  4M9Z A;  4F44 A;  1N3K A;  3J6J A;  3QF2 A;  2MS8 A;  4IZA B;  2N00 A;  1PN5 A;  2KN6 A;  4N1K A;  2DBD A;  2MPC A;  2VGQ A;  3CRD A;  1NGR A;  4ZBW A;  1CWW A;  2YU0 A;  2N1F A;  4RHW E;  1DGN A;  2YQF A;  1C15 A;  2LWD A;  2DBH A;  3MOP G;  3MOP K;  4LWD A;  2BBR A;  2LS7 A;  3LQQ A;  4RHW A;  4N1L A;  2A9I A;  2P1H A;  3EZQ A;  2MS7 A;  4I16 A;  4JQW A;  2BBZ A;  2N97 A;  2L6A A;  2KM6 A;  1ICH A;  4QOB A;  3KAT A;  2DBG A;  4JUP A;  2HM2 Q;  2NZ7 A;  2YGS A;  1WH4 A;  3EZQ B;  2F1S A;  2M5V A;  4A2W A;  4O7Q A;  4NQK A;  1CY5 A;  1D2Z A;  2N80 A;  1E3Y A;  1A1W A;  2MB9 A;  4IZ7 B;  4M9S A;  4FH0 A;  1FAD A;  4N1J A;  4E9M A;  2IB1 A;  3YGS C;  3YGS P;  4UZ0 A;  1DDF A;  1WMG A;  3T6P A; 
#chains in the Genus database with same CATH topology
 4F42 A;  4M9X A;  2GF5 A;  2DBF A;  3J63 A;  4P4H A;  2NAQ A;  2G7R A;  2D96 A;  1Z6T A;  1YGO A;  2N7Z A;  4DWN A;  1E41 A;  4IZ5 E;  2A5Y B;  1WXP A;  2NSN A;  2XV9 A;  4A2Q A;  4O9F A;  1UCP A;  2OF5 H;  4P4H I;  2OF5 A;  2O71 A;  2N83 A;  3MOP A;  2YVI A;  4O6X A;  2MN4 A;  2B1W A;  4EWI A;  3CL3 A;  2DO9 A;  2LWE A;  1A1Z A;  4O9L A;  2L9M A;  3LQR A;  4D8O A;  1D2Z B;  4M9Z A;  4F44 A;  1N3K A;  3J6J A;  3QF2 A;  2MS8 A;  4IZA B;  2N00 A;  1PN5 A;  2KN6 A;  4N1K A;  2DBD A;  2MPC A;  2VGQ A;  3CRD A;  1NGR A;  4ZBW A;  1CWW A;  2YU0 A;  2N1F A;  4RHW E;  1DGN A;  2YQF A;  1C15 A;  2LWD A;  2DBH A;  3MOP G;  3MOP K;  4LWD A;  2BBR A;  2LS7 A;  3LQQ A;  4RHW A;  4N1L A;  2A9I A;  2P1H A;  3EZQ A;  2MJM A;  2MS7 A;  4I16 A;  4JQW A;  2BBZ A;  2N97 A;  2L6A A;  2KM6 A;  1ICH A;  4QOB A;  3KAT A;  2DBG A;  4JUP A;  2HM2 Q;  2NZ7 A;  2YGS A;  1WH4 A;  3EZQ B;  2F1S A;  2M5V A;  4A2W A;  4O7Q A;  4NQK A;  1CY5 A;  1D2Z A;  2N80 A;  1E3Y A;  1A1W A;  2MB9 A;  4IZ7 B;  4M9S A;  4FH0 A;  1FAD A;  4N1J A;  4E9M A;  2IB1 A;  3YGS C;  3YGS P;  4UZ0 A;  1DDF A;  1WMG A;  3T6P A; 
#chains in the Genus database with same CATH homology
 4F42 A;  4M9X A;  2GF5 A;  2DBF A;  3J63 A;  4P4H A;  2NAQ A;  2G7R A;  2D96 A;  1Z6T A;  1YGO A;  2N7Z A;  4DWN A;  1E41 A;  4IZ5 E;  2A5Y B;  1WXP A;  2NSN A;  2XV9 A;  4A2Q A;  4O9F A;  1UCP A;  2OF5 H;  4P4H I;  2OF5 A;  2O71 A;  2N83 A;  3MOP A;  2YVI A;  4O6X A;  2MN4 A;  2B1W A;  4EWI A;  3CL3 A;  2DO9 A;  2LWE A;  1A1Z A;  4O9L A;  2L9M A;  3LQR A;  4D8O A;  1D2Z B;  4M9Z A;  4F44 A;  1N3K A;  3J6J A;  3QF2 A;  2MS8 A;  4IZA B;  2N00 A;  1PN5 A;  2KN6 A;  4N1K A;  2DBD A;  2MPC A;  2VGQ A;  3CRD A;  1NGR A;  4ZBW A;  1CWW A;  2YU0 A;  2N1F A;  4RHW E;  1DGN A;  2YQF A;  1C15 A;  2LWD A;  2DBH A;  3MOP G;  3MOP K;  4LWD A;  2BBR A;  2LS7 A;  3LQQ A;  4RHW A;  4N1L A;  2A9I A;  2P1H A;  3EZQ A;  2MJM A;  2MS7 A;  4I16 A;  4JQW A;  2BBZ A;  2N97 A;  2L6A A;  2KM6 A;  1ICH A;  4QOB A;  3KAT A;  2DBG A;  4JUP A;  2HM2 Q;  2NZ7 A;  2YGS A;  1WH4 A;  3EZQ B;  2F1S A;  2M5V A;  4A2W A;  4O7Q A;  4NQK A;  1CY5 A;  1D2Z A;  2N80 A;  1E3Y A;  1A1W A;  2MB9 A;  4IZ7 B;  4M9S A;  4FH0 A;  1FAD A;  4N1J A;  4E9M A;  2IB1 A;  3YGS C;  3YGS P;  4UZ0 A;  1DDF A;  1WMG A;  3T6P A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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