2AB4A

Dissecting the roles of a strictly conserved tyrosine in substrate recognition and catalysis by pseudouridine 55 synthase
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
308
structure length
300
Chain Sequence
MKHGILVAYKPKGPTSHDVVDEVRKKLKTRKVGHGGTLDPFACGVLIIGVNQGTRILEFYKDLKKVFWVKMRLGLITETFDITGEVVEERECNVTEEEIREAIFSFVGEYDQVPPAYSAKKYKGERLYKLAREGKIINLPPKRVKIFKIWDVNIEGRDVSFRVEVSPGTYIRSLCMDIGYKLGCGATAVELVRESVGPHTIEESLNVFEAAPEEIENRIIPLEKCLEWLPRVVVHQESTKMILNGSQIHLEMLKEWDGFKKGEVVRVFNEEGRLLALAEAERNSSFRQERVLTLRKVFQT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords 5'-R(*CP*CP*AP*CP*GP*GP*UP*(FHU)P*CP*GP*AP*AP*UP*CP*CP*GP*UP
publication title Dissecting the roles of a strictly conserved tyrosine in substrate recognition and catalysis by pseudouridine 55 synthase.
pubmed doi rcsb
source organism Thermotoga maritima
molecule tags Isomerase/rna
total genus 81
structure length 300
sequence length 308
ec nomenclature ec 5.4.99.25: tRNA pseudouridine(55) synthase.
pdb deposition date 2005-07-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01472 PUA PUA domain
A PF01509 TruB_N TruB family pseudouridylate synthase (N terminal domain)
A PF16198 TruB_C_2 tRNA pseudouridylate synthase B C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.130.10 Mainly Beta Roll Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 PUA domain 2ab4A02
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 2ab4A01
2Q07A 1WXWA 1V9KA 2EY4A 2ISTA 4LABA 3HAXA 1IQ8A 3DH3A 1R3EA 2I82A 1K8WA 3HJYA 1ZS7A 1QYUA 1ZL3A 1PRZA 4LGTA 1XPIA 1R3FA 2J5VA 2AUSA 3LWQA 3C0KA 3HJWA 3LWVA 1IT8A 2B78A 2RFKA 4DMGA 3LWPA 3LWRA 3UAIA 3D79A 3LWOA 1J2BA 2AB4A 1KSVA 2APOA 1Q7HA 1T5YA 1KSKA 2HVYA 1ZE2A 2AS0A 1WXXA 2CX1A 4Q1TA 3VSEA 2CX0A 2CWWA 1KSLA 2J5TA 1ZE1A 3MQKA 3LDFA 1SGVA 1V9FA 1IT7A 3U28A 2P38A 1SQWA
chains in the Genus database with same CATH superfamily
1WXWA 3M6WA 1IQ8A 1R3EA 1XNEA 1SZWA 1ZL3A 2J5VA 3HJWA 2B78A 1UOYA 4DMGA 1ZBOA 2AB4A 1KSVA 2APOA 1T5YA 1WXXA 4Q1TA 2FRXA 3MQKA 1V9FA 2Q07A 1S04A 3M4XA 1K8WA 1TE7A 1PRZA 2KKUA 2DP9A 4TZ4C 4CI1B 2RFKA 3M6UA 4CI3B 1WK2A 1Q7HA 1SB7A 2ANEA 2CX1A 3ZV0C 2CX0A 2CWWA 2J5TA 3U28A 2P38A 1SQWA 2EY4A 1V9KA 2ISTA 3DH3A 1Z2ZA 1QYUA 2AUSA 3M6VA 3LWQA 2E5OA 3C0KA 2Z0TA 3LWVA 1IT8A 3LWPA 3LWOA 1J2BA 3IUWA 1KSKA 2HVYA 3LJCA 1ZE1A 3LDFA 3HAXA 4LABA 1SI7A 2I82A 3M6XA 3HJYA 1ZS7A 4LGTA 1XPIA 1R3FA 3M65A 3LWRA 3UAIA 3D79A 1ZE2A 2AS0A 4CI2B 3VSEA 1KSLA 1SGVA 1IT7A
chains in the Genus database with same CATH topology
2Q07A 1WXWA 1V9KA 2EY4A 2ISTA 4LABA 3HAXA 1SI7A 1IQ8A 3DH3A 1R3EA 2I82A 1K8WA 3HJYA 1SZWA 1ZS7A 1Z2ZA 1QYUA 1ZL3A 1PRZA 4LGTA 1XPIA 1R3FA 2J5VA 2AUSA 3LWQA 3C0KA 3HJWA 3LWVA 1IT8A 2B78A 2RFKA 4DMGA 3LWPA 3LWRA 3UAIA 3D79A 3LWOA 1J2BA 2AB4A 1KSVA 2APOA 1Q7HA 1T5YA 1SB7A 1KSKA 2HVYA 1ZE2A 2AS0A 1WXXA 2CX1A 4Q1TA 3VSEA 2CX0A 2CWWA 1KSLA 2J5TA 1ZE1A 3MQKA 3LDFA 1SGVA 1V9FA 1IT7A 3U28A 2P38A 1SQWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Q07 A;  1WXW A;  1V9K A;  2EY4 A;  2IST A;  4LAB A;  3HAX A;  1IQ8 A;  3DH3 A;  1R3E A;  2I82 A;  1K8W A;  3HJY A;  1ZS7 A;  1QYU A;  1ZL3 A;  1PRZ A;  4LGT A;  1XPI A;  1R3F A;  2J5V A;  2AUS A;  3LWQ A;  3C0K A;  3HJW A;  3LWV A;  1IT8 A;  2B78 A;  2RFK A;  4DMG A;  3LWP A;  3LWR A;  3UAI A;  3D79 A;  3LWO A;  1J2B A;  2AB4 A;  1KSV A;  2APO A;  1Q7H A;  1T5Y A;  1KSK A;  2HVY A;  1ZE2 A;  2AS0 A;  1WXX A;  2CX1 A;  4Q1T A;  3VSE A;  2CX0 A;  2CWW A;  1KSL A;  2J5T A;  1ZE1 A;  3MQK A;  3LDF A;  1SGV A;  1V9F A;  1IT7 A;  3U28 A;  2P38 A;  1SQW A; 
#chains in the Genus database with same CATH topology
 1WXW A;  3M6W A;  1IQ8 A;  1R3E A;  1XNE A;  1SZW A;  1ZL3 A;  2J5V A;  3HJW A;  2B78 A;  1UOY A;  4DMG A;  1ZBO A;  2AB4 A;  1KSV A;  2APO A;  1T5Y A;  1WXX A;  4Q1T A;  2FRX A;  3MQK A;  1V9F A;  2Q07 A;  1S04 A;  3M4X A;  1K8W A;  1TE7 A;  1PRZ A;  2KKU A;  2DP9 A;  4TZ4 C;  4CI1 B;  2RFK A;  3M6U A;  4CI3 B;  1WK2 A;  1Q7H A;  1SB7 A;  2ANE A;  2CX1 A;  3ZV0 C;  2CX0 A;  2CWW A;  2J5T A;  3U28 A;  2P38 A;  1SQW A;  2EY4 A;  1V9K A;  2IST A;  3DH3 A;  1Z2Z A;  1QYU A;  2AUS A;  3M6V A;  3LWQ A;  2E5O A;  3C0K A;  2Z0T A;  3LWV A;  1IT8 A;  3LWP A;  3LWO A;  1J2B A;  3IUW A;  1KSK A;  2HVY A;  3LJC A;  1ZE1 A;  3LDF A;  3HAX A;  4LAB A;  1SI7 A;  2I82 A;  3M6X A;  3HJY A;  1ZS7 A;  4LGT A;  1XPI A;  1R3F A;  3M65 A;  3LWR A;  3UAI A;  3D79 A;  1ZE2 A;  2AS0 A;  4CI2 B;  3VSE A;  1KSL A;  1SGV A;  1IT7 A; 
#chains in the Genus database with same CATH homology
 2Q07 A;  1WXW A;  1V9K A;  2EY4 A;  2IST A;  4LAB A;  3HAX A;  1SI7 A;  1IQ8 A;  3DH3 A;  1R3E A;  2I82 A;  1K8W A;  3HJY A;  1SZW A;  1ZS7 A;  1Z2Z A;  1QYU A;  1ZL3 A;  1PRZ A;  4LGT A;  1XPI A;  1R3F A;  2J5V A;  2AUS A;  3LWQ A;  3C0K A;  3HJW A;  3LWV A;  1IT8 A;  2B78 A;  2RFK A;  4DMG A;  3LWP A;  3LWR A;  3UAI A;  3D79 A;  3LWO A;  1J2B A;  2AB4 A;  1KSV A;  2APO A;  1Q7H A;  1T5Y A;  1SB7 A;  1KSK A;  2HVY A;  1ZE2 A;  2AS0 A;  1WXX A;  2CX1 A;  4Q1T A;  3VSE A;  2CX0 A;  2CWW A;  1KSL A;  2J5T A;  1ZE1 A;  3MQK A;  3LDF A;  1SGV A;  1V9F A;  1IT7 A;  3U28 A;  2P38 A;  1SQW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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