2AB4A

Dissecting the roles of a strictly conserved tyrosine in substrate recognition and catalysis by pseudouridine 55 synthase
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
308
structure length
300
Chain Sequence
b'MKHGILVAYKPKGPTSHDVVDEVRKKLKTRKVGHGGTLDPFACGVLIIGVNQGTRILEFYKDLKKVFWVKMRLGLITETFDITGEVVEERECNVTEEEIREAIFSFVGEYDQVPPAYSAKKYKGERLYKLAREGKIINLPPKRVKIFKIWDVNIEGRDVSFRVEVSPGTYIRSLCMDIGYKLGCGATAVELVRESVGPHTIEESLNVFEAAPEEIENRIIPLEKCLEWLPRVVVHQESTKMILNGSQIHLEMLKEWDGFKKGEVVRVFNEEGRLLALAEAERNSSFRQERVLTLRKVFQT'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords 5'-R(*CP*CP*AP*CP*GP*GP*UP*(FHU)P*CP*GP*AP*AP*UP*CP*CP*GP*UP
publication title Dissecting the roles of a strictly conserved tyrosine in substrate recognition and catalysis by pseudouridine 55 synthase.
pubmed doi rcsb
source organism Thermotoga maritima
molecule tags Isomerase/rna
total genus 81
structure length 300
sequence length 308
ec nomenclature ec 5.4.99.25: tRNA pseudouridine(55) synthase.
pdb deposition date 2005-07-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01472 PUA PUA domain
A PF01509 TruB_N TruB family pseudouridylate synthase (N terminal domain)
A PF16198 TruB_C_2 tRNA pseudouridylate synthase B C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.130.10 Mainly Beta Roll Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 PUA domain 2ab4A02
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 2ab4A01
3LWVA 1SGVA 3HAXA 2J5TA 3LWOA 2AS0A 2I82A 3VSEA 1IT7A 2Q07A 1V9KA 3LWRA 3DH3A 2APOA 3LWQA 2ISTA 2CWWA 4LABA 1KSKA 1SQWA 3HJWA 4LGTA 2B78A 3U28A 1R3FA 3LWPA 1PRZA 1ZL3A 3D79A 1QYUA 1ZS7A 4Q1TA 2RFKA 1XPIA 1WXXA 1ZE1A 1K8WA 1Q7HA 2CX0A 1KSVA 1V9FA 2AUSA 1J2BA 3HJYA 1IT8A 3LDFA 1T5YA 4DMGA 2EY4A 1IQ8A 1R3EA 2J5VA 2AB4A 1KSLA 3MQKA 2P38A 2CX1A 3C0KA 2HVYA 1WXWA 1ZE2A 3UAIA
chains in the Genus database with same CATH superfamily
1WK2A 3LWVA 3HAXA 3LWOA 2AS0A 2I82A 3VSEA 1IT7A 3DH3A 3LWQA 1SZWA 1ZBOA 1SQWA 4LGTA 1R3FA 4CI3B 1ZS7A 1ZE1A 3M6VA 1J2BA 2J5VA 3MQKA 2CX1A 3IUWA 1ZE2A 3LJCA 4CI2B 1SGVA 1XNEA 3M65A 2Q07A 3LWRA 2ISTA 1KSKA 3U28A 2B78A 3LWPA 1TE7A 4CI1B 1SI7A 2RFKA 1XPIA 1WXXA 2Z0TA 1KSVA 1V9FA 3HJYA 1T5YA 2EY4A 1KSLA 2KKUA 1V9KA 2APOA 2CWWA 4LABA 2FRXA 2ANEA 3HJWA 1ZL3A 3D79A 1K8WA 1Q7HA 2CX0A 2AUSA 3M6WA 1S04A 4DMGA 1IQ8A 1R3EA 2P38A 3C0KA 3ZV0C 3M4XA 1Z2ZA 3M6UA 2DP9A 2J5TA 1PRZA 1QYUA 4Q1TA 1IT8A 2E5OA 3LDFA 1SB7A 4TZ4C 3M6XA 2AB4A 2HVYA 1UOYA 1WXWA 3UAIA
chains in the Genus database with same CATH topology
3LWVA 1Z2ZA 1SGVA 3HAXA 2J5TA 3LWOA 2AS0A 2I82A 3VSEA 1IT7A 2Q07A 1V9KA 3LWRA 3DH3A 2APOA 3LWQA 2ISTA 2CWWA 1SZWA 1KSKA 4LABA 1SQWA 3HJWA 4LGTA 2B78A 3U28A 1R3FA 3LWPA 1PRZA 1ZL3A 3D79A 1QYUA 1ZS7A 4Q1TA 1SI7A 2RFKA 1XPIA 1WXXA 1ZE1A 1K8WA 1Q7HA 2CX0A 1KSVA 1V9FA 2AUSA 1J2BA 3HJYA 1IT8A 3LDFA 1T5YA 1SB7A 4DMGA 2EY4A 1IQ8A 1R3EA 2J5VA 2AB4A 1KSLA 3MQKA 2P38A 2CX1A 3C0KA 2HVYA 1WXWA 1ZE2A 3UAIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LWV A;  1SGV A;  3HAX A;  2J5T A;  3LWO A;  2AS0 A;  2I82 A;  3VSE A;  1IT7 A;  2Q07 A;  1V9K A;  3LWR A;  3DH3 A;  2APO A;  3LWQ A;  2IST A;  2CWW A;  4LAB A;  1KSK A;  1SQW A;  3HJW A;  4LGT A;  2B78 A;  3U28 A;  1R3F A;  3LWP A;  1PRZ A;  1ZL3 A;  3D79 A;  1QYU A;  1ZS7 A;  4Q1T A;  2RFK A;  1XPI A;  1WXX A;  1ZE1 A;  1K8W A;  1Q7H A;  2CX0 A;  1KSV A;  1V9F A;  2AUS A;  1J2B A;  3HJY A;  1IT8 A;  3LDF A;  1T5Y A;  4DMG A;  2EY4 A;  1IQ8 A;  1R3E A;  2J5V A;  2AB4 A;  1KSL A;  3MQK A;  2P38 A;  2CX1 A;  3C0K A;  2HVY A;  1WXW A;  1ZE2 A;  3UAI A; 
#chains in the Genus database with same CATH topology
 1WK2 A;  3LWV A;  3HAX A;  3LWO A;  2AS0 A;  2I82 A;  3VSE A;  1IT7 A;  3DH3 A;  3LWQ A;  1SZW A;  1ZBO A;  1SQW A;  4LGT A;  1R3F A;  4CI3 B;  1ZS7 A;  1ZE1 A;  3M6V A;  1J2B A;  2J5V A;  3MQK A;  2CX1 A;  3IUW A;  1ZE2 A;  3LJC A;  4CI2 B;  1SGV A;  1XNE A;  3M65 A;  2Q07 A;  3LWR A;  2IST A;  1KSK A;  3U28 A;  2B78 A;  3LWP A;  1TE7 A;  4CI1 B;  1SI7 A;  2RFK A;  1XPI A;  1WXX A;  2Z0T A;  1KSV A;  1V9F A;  3HJY A;  1T5Y A;  2EY4 A;  1KSL A;  2KKU A;  1V9K A;  2APO A;  2CWW A;  4LAB A;  2FRX A;  2ANE A;  3HJW A;  1ZL3 A;  3D79 A;  1K8W A;  1Q7H A;  2CX0 A;  2AUS A;  3M6W A;  1S04 A;  4DMG A;  1IQ8 A;  1R3E A;  2P38 A;  3C0K A;  3ZV0 C;  3M4X A;  1Z2Z A;  3M6U A;  2DP9 A;  2J5T A;  1PRZ A;  1QYU A;  4Q1T A;  1IT8 A;  2E5O A;  3LDF A;  1SB7 A;  4TZ4 C;  3M6X A;  2AB4 A;  2HVY A;  1UOY A;  1WXW A;  3UAI A; 
#chains in the Genus database with same CATH homology
 3LWV A;  1Z2Z A;  1SGV A;  3HAX A;  2J5T A;  3LWO A;  2AS0 A;  2I82 A;  3VSE A;  1IT7 A;  2Q07 A;  1V9K A;  3LWR A;  3DH3 A;  2APO A;  3LWQ A;  2IST A;  2CWW A;  1SZW A;  1KSK A;  4LAB A;  1SQW A;  3HJW A;  4LGT A;  2B78 A;  3U28 A;  1R3F A;  3LWP A;  1PRZ A;  1ZL3 A;  3D79 A;  1QYU A;  1ZS7 A;  4Q1T A;  1SI7 A;  2RFK A;  1XPI A;  1WXX A;  1ZE1 A;  1K8W A;  1Q7H A;  2CX0 A;  1KSV A;  1V9F A;  2AUS A;  1J2B A;  3HJY A;  1IT8 A;  3LDF A;  1T5Y A;  1SB7 A;  4DMG A;  2EY4 A;  1IQ8 A;  1R3E A;  2J5V A;  2AB4 A;  1KSL A;  3MQK A;  2P38 A;  2CX1 A;  3C0K A;  2HVY A;  1WXW A;  1ZE2 A;  3UAI A; 
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