2AF0A

Structure of the regulator of g-protein signaling domain of rgs2
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
146
structure length
146
Chain Sequence
ADLGTENLYFQSMKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords Regulator of G-protein signaling 2
publication title Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
pubmed doi rcsb
source organism Homo sapiens
total genus 51
structure length 146
sequence length 146
ec nomenclature
pdb deposition date 2005-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00615 RGS Regulator of G protein signaling domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.167.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 2 Regulator of G-protein Signalling 4, domain 2 2af0A02
1.10.196.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 1 Regulator of G-protein Signalling 4; domain 1 2af0A01
1AGRE 1OMWA 4MK0A 2JNUA 1EMUA 2V4ZB 3PVUA 1DK8A 5HE1A 2OWIA 3PVWA 4TNBA 3KRWA 2AF0A 2DLVA 2IK8B 4EKDB 4PNKA 1EZYA 1FQIA 2EBZA 3CIKA 1EZTA 4TNDA 3KRXA 2JM5A 3C7KB 2BT2A 3NYNA 5HE3A 2GTPC 1FQJB 2D9JA 5HE0A 3V5WA 5DO9B 3NYOA 3UZTA 2IHDA 2BCJA 2CRPA 3C7LA 1FQKB 1CMZA 2ODEB 3PSCA 5HE2A 2OJ4A 2IHBB 2BV1A
chains in the Genus database with same CATH superfamily
1AGRE 4HTEA 1OMWA 3I5QA 4MK0A 2JNUA 1EMUA 2V4ZB 3PVUA 1DK8A 5HE1A 2OWIA 3PVWA 4TNBA 3KRWA 2AF0A 2DLVA 2IK8B 4EKDB 4PNKA 1EZYA 1FQIA 3QYFA 2EBZA 3CIKA 1EZTA 4TNDA 3KRXA 2JM5A 3C7KB 2BT2A 3NYNA 5HE3A 2GTPC 1FQJB 2D9JA 5HE0A 3V5WA 5REQB 5DO9B 3NYOA 3UZTA 2IHDA 2BCJA 2CRPA 3C7LA 1FQKB 1CMZA 2ODEB 3PSCA 5HE2A 2OJ4A 2IHBB 2BV1A
chains in the Genus database with same CATH topology
1AGRE 1OMWA 4MK0A 2JNUA 1EMUA 2V4ZB 3PVUA 1DK8A 5HE1A 2OWIA 3PVWA 4TNBA 3KRWA 2AF0A 2DLVA 2IK8B 4EKDB 4PNKA 1EZYA 1FQIA 3QYFA 2EBZA 3CIKA 1EZTA 4TNDA 3KRXA 2JM5A 3C7KB 2BT2A 3NYNA 5HE3A 2GTPC 1FQJB 2D9JA 5HE0A 3V5WA 5REQB 5DO9B 3NYOA 3UZTA 2IHDA 2BCJA 2CRPA 3C7LA 1FQKB 1CMZA 2ODEB 3PSCA 5HE2A 2OJ4A 2IHBB 2BV1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AGR E;  1OMW A;  4MK0 A;  2JNU A;  1EMU A;  2V4Z B;  3PVU A;  1DK8 A;  5HE1 A;  2OWI A;  3PVW A;  4TNB A;  3KRW A;  2AF0 A;  2DLV A;  2IK8 B;  4EKD B;  4PNK A;  1EZY A;  1FQI A;  2EBZ A;  3CIK A;  1EZT A;  4TND A;  3KRX A;  2JM5 A;  3C7K B;  2BT2 A;  3NYN A;  5HE3 A;  2GTP C;  1FQJ B;  2D9J A;  5HE0 A;  3V5W A;  5DO9 B;  3NYO A;  3UZT A;  2IHD A;  2BCJ A;  2CRP A;  3C7L A;  1FQK B;  1CMZ A;  2ODE B;  3PSC A;  5HE2 A;  2OJ4 A;  2IHB B;  2BV1 A; 
#chains in the Genus database with same CATH topology
 1AGR E;  4HTE A;  1OMW A;  3I5Q A;  4MK0 A;  2JNU A;  1EMU A;  2V4Z B;  3PVU A;  1DK8 A;  5HE1 A;  2OWI A;  3PVW A;  4TNB A;  3KRW A;  2AF0 A;  2DLV A;  2IK8 B;  4EKD B;  4PNK A;  1EZY A;  1FQI A;  3QYF A;  2EBZ A;  3CIK A;  1EZT A;  4TND A;  3KRX A;  2JM5 A;  3C7K B;  2BT2 A;  3NYN A;  5HE3 A;  2GTP C;  1FQJ B;  2D9J A;  5HE0 A;  3V5W A;  5REQ B;  5DO9 B;  3NYO A;  3UZT A;  2IHD A;  2BCJ A;  2CRP A;  3C7L A;  1FQK B;  1CMZ A;  2ODE B;  3PSC A;  5HE2 A;  2OJ4 A;  2IHB B;  2BV1 A; 
#chains in the Genus database with same CATH homology
 1AGR E;  1OMW A;  4MK0 A;  2JNU A;  1EMU A;  2V4Z B;  3PVU A;  1DK8 A;  5HE1 A;  2OWI A;  3PVW A;  4TNB A;  3KRW A;  2AF0 A;  2DLV A;  2IK8 B;  4EKD B;  4PNK A;  1EZY A;  1FQI A;  3QYF A;  2EBZ A;  3CIK A;  1EZT A;  4TND A;  3KRX A;  2JM5 A;  3C7K B;  2BT2 A;  3NYN A;  5HE3 A;  2GTP C;  1FQJ B;  2D9J A;  5HE0 A;  3V5W A;  5REQ B;  5DO9 B;  3NYO A;  3UZT A;  2IHD A;  2BCJ A;  2CRP A;  3C7L A;  1FQK B;  1CMZ A;  2ODE B;  3PSC A;  5HE2 A;  2OJ4 A;  2IHB B;  2BV1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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