2AJGA

Crystal structure of the editing domain of e. coli leucyl-trna synthetase
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
186
structure length
186
Chain Sequence
EGVEITFNVNDYDNTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEKKGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Ligase
molecule keywords Leucyl-tRNA synthetase
publication title Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination
pubmed doi rcsb
source organism Escherichia coli
total genus 51
structure length 186
sequence length 186
chains with identical sequence B
ec nomenclature ec 6.1.1.4: Leucine--tRNA ligase.
pdb deposition date 2005-08-01
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.740.10 Alpha Beta Alpha-Beta Complex Isoleucyl-tRNA Synthetase; domain 2 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain 2ajgA00
4AS1A 1WNZA 2AJIA 2BYTA 1WK9A 1WKBA 1ILEA 1IVSA 1WNYA 5AGRA 1QU2A 3PZ5A 3PZ6A 4AQ7A 4ARCA 4K47A 2AJHA 3ZJUA 5AGJA 1JZQA 1OBCA 3ZJVA 3O0AA 3ZGZA 1H3NA 4CQNA 1QU3A 2WFDA 2WFEA 5AGTA 3PZ0A 2V0GA 1FFYA 1UDZA 1WKAA 1JZSA 4K48A 5AGIA 5AGSA 2WFGA 1UE0A 2AJGA 2V0CA 1GAXA 1WK8A 5AGHA 4ARIA 3ZJTA 1OBHA 2BTEA 1WZ2A
chains in the Genus database with same CATH superfamily
4AS1A 1WNZA 2AJIA 2BYTA 1WK9A 1WKBA 1ILEA 1IVSA 1WNYA 5AGRA 1QU2A 3PZ5A 3PZ6A 4AQ7A 4ARCA 4K47A 2AJHA 3ZJUA 5AGJA 1JZQA 1OBCA 3ZJVA 3O0AA 3ZGZA 1H3NA 4CQNA 1QU3A 2WFDA 2WFEA 5AGTA 3PZ0A 2V0GA 1FFYA 1UDZA 1WKAA 1JZSA 4K48A 5AGIA 5AGSA 2WFGA 1UE0A 2AJGA 2V0CA 1GAXA 1WK8A 5AGHA 4ARIA 3ZJTA 1OBHA 2BTEA 1WZ2A
chains in the Genus database with same CATH topology
4AS1A 1WNZA 2AJIA 2BYTA 1WK9A 1WKBA 1ILEA 1IVSA 1WNYA 5AGRA 1QU2A 3PZ5A 3PZ6A 4AQ7A 4ARCA 4K47A 2AJHA 3ZJUA 5AGJA 1JZQA 1OBCA 3ZJVA 3O0AA 3ZGZA 1H3NA 4CQNA 1QU3A 2WFDA 2WFEA 5AGTA 3PZ0A 2V0GA 1FFYA 1UDZA 1WKAA 1JZSA 4K48A 5AGIA 5AGSA 2WFGA 1UE0A 2AJGA 2V0CA 1GAXA 1WK8A 5AGHA 4ARIA 3ZJTA 1OBHA 2BTEA 1WZ2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AS1 A;  1WNZ A;  2AJI A;  2BYT A;  1WK9 A;  1WKB A;  1ILE A;  1IVS A;  1WNY A;  5AGR A;  1QU2 A;  3PZ5 A;  3PZ6 A;  4AQ7 A;  4ARC A;  4K47 A;  2AJH A;  3ZJU A;  5AGJ A;  1JZQ A;  1OBC A;  3ZJV A;  3O0A A;  3ZGZ A;  1H3N A;  4CQN A;  1QU3 A;  2WFD A;  2WFE A;  5AGT A;  3PZ0 A;  2V0G A;  1FFY A;  1UDZ A;  1WKA A;  1JZS A;  4K48 A;  5AGI A;  5AGS A;  2WFG A;  1UE0 A;  2AJG A;  2V0C A;  1GAX A;  1WK8 A;  5AGH A;  4ARI A;  3ZJT A;  1OBH A;  2BTE A;  1WZ2 A; 
#chains in the Genus database with same CATH topology
 4AS1 A;  1WNZ A;  2AJI A;  2BYT A;  1WK9 A;  1WKB A;  1ILE A;  1IVS A;  1WNY A;  5AGR A;  1QU2 A;  3PZ5 A;  3PZ6 A;  4AQ7 A;  4ARC A;  4K47 A;  2AJH A;  3ZJU A;  5AGJ A;  1JZQ A;  1OBC A;  3ZJV A;  3O0A A;  3ZGZ A;  1H3N A;  4CQN A;  1QU3 A;  2WFD A;  2WFE A;  5AGT A;  3PZ0 A;  2V0G A;  1FFY A;  1UDZ A;  1WKA A;  1JZS A;  4K48 A;  5AGI A;  5AGS A;  2WFG A;  1UE0 A;  2AJG A;  2V0C A;  1GAX A;  1WK8 A;  5AGH A;  4ARI A;  3ZJT A;  1OBH A;  2BTE A;  1WZ2 A; 
#chains in the Genus database with same CATH homology
 4AS1 A;  1WNZ A;  2AJI A;  2BYT A;  1WK9 A;  1WKB A;  1ILE A;  1IVS A;  1WNY A;  5AGR A;  1QU2 A;  3PZ5 A;  3PZ6 A;  4AQ7 A;  4ARC A;  4K47 A;  2AJH A;  3ZJU A;  5AGJ A;  1JZQ A;  1OBC A;  3ZJV A;  3O0A A;  3ZGZ A;  1H3N A;  4CQN A;  1QU3 A;  2WFD A;  2WFE A;  5AGT A;  3PZ0 A;  2V0G A;  1FFY A;  1UDZ A;  1WKA A;  1JZS A;  4K48 A;  5AGI A;  5AGS A;  2WFG A;  1UE0 A;  2AJG A;  2V0C A;  1GAX A;  1WK8 A;  5AGH A;  4ARI A;  3ZJT A;  1OBH A;  2BTE A;  1WZ2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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