2ANHA

Alkaline phosphatase (d153h)
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
total genus 164
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-09-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2anhA00
1EJJA 1KHJA 5IJSA 4GTXA 2IUCA 5LRMA 1URAA 1ANIA 2W5QA 3M8YA 3OT9A 3WAXA 4KAYA 1ANJA 2GLQA 1AUKA 1HJKA 2D1GA 3M8WA 1N2KA 2W5VA 4NWJA 4LR8A 5EGEA 3WBHA 3WAVA 4MY4A 1KH4A 5LIAA 1EW2A 1ALKA 3NKRA 4ZG7A 4UPIA 4TN0A 5L0BA 3E2DA 1P49A 4YR1A 4LR2A 3T00A 3T01A 5LRNA 1HDHA 3UN3A 1O99A 3NVLA 3UNYA 5DLTA 1EI6A 4CYSA 1SHQA 1ALHA 3MK0A 3UN5A 4UPLA 3BDGB 1AJDA 3WAYA 1ELZA 3M8ZA 3NKOA 4KAVA 3BDHA 1ELXA 3IGZB 1KHLA 4CXUA 4CXSA 4UPKA 3ED4A 5KXAA 1KH9A 5LQQA 1ALJA 3IDDA 4ZG6A 5GRRA 2VQRA 2G9YA 4GTYA 4ZGAA 1O98A 1KHKA 3B5QA 2W5XA 2X98A 4GTZA 2W8SA 3M7VA 4FDJA 4GTWA 1E3CP 3A52A 4LR9A 2W5TA 3BDGA 4UORA 2QZUA 1ED9A 2W5SA 2ANHA 3Q3QA 5INHA 4LRFA 1EW9A 1ED8A 2IFYA 4MIVA 4NWXA 3DYCA 2GSOA 3T02A 3MK2A 3NKPA 2GSUA 2W8DA 5EGHA 1AJCA 3IGYB 1HQAA 1URBA 5TJ3A 1ZEDA 2RH6A 1B8JA 1KH7A 1ZEBA 4LRCA 1ALIA 2GA3A 1Y7AA 4KJDA 2XRGA 4QAXA 3NKMA 4LRAA 3UO0A 4LRDA 3NKQA 1EW8A 1ZEFA 4KM4A 1Y6VA 1ELYA 4LQYA 3KD8A 5L0KA 3UN2A 1E2SP 5AJ9A 4MHXA 4FDIA 2GSNA 1FSUA 2W5RA 5L0EA 4LR7A 1K7HA 2W5WA 2ZKTA 4B56A 3MK1A 1KHNA 2IUCB 4KJGA 4CXKA 4LREA 4ZG9A 3BDFA 1E33P 5GOVA 5IJQA 3CMRA 5HRTA 3WAWA 2XR9A 4CYRA 3SZYA 1EQJA 3LXQA 4UOOA 5C66A 3TWZA 4N7TA 4UOPA 3NKNA 5DLWA 5DLVA 1AJAA 3DPCA 4UPHA 3TG0A 1E1ZP 1SHNA 3TX0A 1AJBA 4LRBA 5K4PA 3SZZA 1KH5A 1N2LA
chains in the Genus database with same CATH superfamily
1EJJA 1KHJA 5IJSA 4GTXA 2IUCA 5LRMA 1URAA 1ANIA 2W5QA 3M8YA 3OT9A 3WAXA 4KAYA 1ANJA 2GLQA 1AUKA 1HJKA 2D1GA 3M8WA 1N2KA 2W5VA 4NWJA 4LR8A 5EGEA 3WBHA 3WAVA 4MY4A 1KH4A 5LIAA 1EW2A 1ALKA 3NKRA 4ZG7A 4UPIA 4TN0A 5L0BA 3E2DA 1P49A 4YR1A 4LR2A 3T00A 3T01A 5LRNA 1HDHA 3UN3A 1O99A 3NVLA 3UNYA 5DLTA 1EI6A 4CYSA 1SHQA 1ALHA 3MK0A 3UN5A 4UPLA 3BDGB 1AJDA 3WAYA 1ELZA 3M8ZA 3NKOA 4KAVA 3BDHA 1ELXA 3IGZB 1KHLA 4CXUA 4CXSA 4UPKA 3ED4A 5KXAA 1KH9A 5LQQA 1ALJA 3IDDA 4ZG6A 5GRRA 2VQRA 2G9YA 4GTYA 4ZGAA 1O98A 1KHKA 3B5QA 2W5XA 2X98A 4GTZA 2W8SA 3M7VA 4FDJA 4GTWA 1E3CP 3A52A 4LR9A 2W5TA 3BDGA 4UORA 2QZUA 1ED9A 2W5SA 2ANHA 3Q3QA 5INHA 4LRFA 1EW9A 1ED8A 2IFYA 4MIVA 4NWXA 3DYCA 2GSOA 3T02A 3MK2A 3NKPA 2GSUA 2W8DA 5EGHA 1AJCA 3IGYB 1HQAA 1URBA 5TJ3A 1ZEDA 2RH6A 1B8JA 1KH7A 1ZEBA 4LRCA 1ALIA 2GA3A 1Y7AA 4KJDA 2XRGA 4QAXA 3NKMA 4LRAA 3UO0A 4LRDA 3NKQA 1EW8A 1ZEFA 4KM4A 1Y6VA 1ELYA 4LQYA 3KD8A 5L0KA 3UN2A 1E2SP 5AJ9A 4MHXA 4FDIA 2GSNA 1FSUA 2W5RA 5L0EA 4LR7A 1K7HA 2W5WA 2ZKTA 4B56A 3MK1A 1KHNA 2IUCB 4KJGA 4CXKA 4LREA 4ZG9A 3BDFA 1E33P 5GOVA 5IJQA 3CMRA 5HRTA 3WAWA 2XR9A 4CYRA 3SZYA 1EQJA 3LXQA 4UOOA 5C66A 3TWZA 4N7TA 4UOPA 3NKNA 5DLWA 5DLVA 1AJAA 3DPCA 4UPHA 3TG0A 1E1ZP 1SHNA 3TX0A 1AJBA 4LRBA 5K4PA 3SZZA 1KH5A 1N2LA
chains in the Genus database with same CATH topology
1EJJA 1KHJA 5IJSA 4GTXA 2IUCA 5LRMA 1URAA 1ANIA 2W5QA 3M8YA 3OT9A 3WAXA 4KAYA 1ANJA 2GLQA 1AUKA 1HJKA 2D1GA 3M8WA 1N2KA 2W5VA 4NWJA 4LR8A 5EGEA 3WBHA 3WAVA 4MY4A 1KH4A 5LIAA 1EW2A 1ALKA 3NKRA 4ZG7A 4UPIA 4TN0A 5L0BA 3E2DA 1P49A 4YR1A 4LR2A 3T00A 3T01A 5LRNA 1HDHA 3UN3A 1O99A 3NVLA 3UNYA 5DLTA 1EI6A 4CYSA 1SHQA 1ALHA 3MK0A 3UN5A 4UPLA 3BDGB 1AJDA 3WAYA 1ELZA 3M8ZA 3NKOA 4KAVA 3BDHA 1ELXA 3IGZB 1KHLA 4CXUA 4CXSA 4UPKA 3ED4A 5KXAA 1KH9A 5LQQA 1ALJA 3IDDA 4ZG6A 5GRRA 2VQRA 2G9YA 4GTYA 4ZGAA 1O98A 1KHKA 3B5QA 2W5XA 2X98A 4GTZA 2W8SA 3M7VA 4FDJA 4GTWA 1E3CP 3A52A 4LR9A 2W5TA 3BDGA 4UORA 2QZUA 1ED9A 2W5SA 2ANHA 3Q3QA 5INHA 4LRFA 1EW9A 1ED8A 2IFYA 4MIVA 4NWXA 3DYCA 2GSOA 3T02A 3MK2A 3NKPA 2GSUA 2W8DA 5EGHA 1AJCA 3IGYB 1HQAA 1URBA 5TJ3A 1ZEDA 2RH6A 1B8JA 1KH7A 1ZEBA 4LRCA 1ALIA 2GA3A 1Y7AA 4KJDA 2XRGA 4QAXA 3NKMA 4LRAA 3UO0A 4LRDA 3NKQA 1EW8A 1ZEFA 4KM4A 1Y6VA 1ELYA 4LQYA 3KD8A 5L0KA 3UN2A 1E2SP 5AJ9A 4MHXA 4FDIA 2GSNA 1FSUA 2W5RA 5L0EA 4LR7A 1K7HA 2W5WA 2ZKTA 4B56A 3MK1A 1KHNA 2IUCB 4KJGA 4CXKA 4LREA 4ZG9A 3BDFA 1E33P 5GOVA 5IJQA 3CMRA 5HRTA 3WAWA 2XR9A 4CYRA 3SZYA 1EQJA 3LXQA 4UOOA 5C66A 3TWZA 4N7TA 4UOPA 3NKNA 5DLWA 5DLVA 1AJAA 3DPCA 4UPHA 3TG0A 1E1ZP 1SHNA 3TX0A 1AJBA 4LRBA 5K4PA 3SZZA 1KH5A 1N2LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EJJ A;  1KHJ A;  5IJS A;  4GTX A;  2IUC A;  5LRM A;  1URA A;  1ANI A;  2W5Q A;  3M8Y A;  3OT9 A;  3WAX A;  4KAY A;  1ANJ A;  2GLQ A;  1AUK A;  1HJK A;  2D1G A;  3M8W A;  1N2K A;  2W5V A;  4NWJ A;  4LR8 A;  5EGE A;  3WBH A;  3WAV A;  4MY4 A;  1KH4 A;  5LIA A;  1EW2 A;  1ALK A;  3NKR A;  4ZG7 A;  4UPI A;  4TN0 A;  5L0B A;  3E2D A;  1P49 A;  4YR1 A;  4LR2 A;  3T00 A;  3T01 A;  5LRN A;  1HDH A;  3UN3 A;  1O99 A;  3NVL A;  3UNY A;  5DLT A;  1EI6 A;  4CYS A;  1SHQ A;  1ALH A;  3MK0 A;  3UN5 A;  4UPL A;  3BDG B;  1AJD A;  3WAY A;  1ELZ A;  3M8Z A;  3NKO A;  4KAV A;  3BDH A;  1ELX A;  3IGZ B;  1KHL A;  4CXU A;  4CXS A;  4UPK A;  3ED4 A;  5KXA A;  1KH9 A;  5LQQ A;  1ALJ A;  3IDD A;  4ZG6 A;  5GRR A;  2VQR A;  2G9Y A;  4GTY A;  4ZGA A;  1O98 A;  1KHK A;  3B5Q A;  2W5X A;  2X98 A;  4GTZ A;  2W8S A;  3M7V A;  4FDJ A;  4GTW A;  1E3C P;  3A52 A;  4LR9 A;  2W5T A;  3BDG A;  4UOR A;  2QZU A;  1ED9 A;  2W5S A;  2ANH A;  3Q3Q A;  5INH A;  4LRF A;  1EW9 A;  1ED8 A;  2IFY A;  4MIV A;  4NWX A;  3DYC A;  2GSO A;  3T02 A;  3MK2 A;  3NKP A;  2GSU A;  2W8D A;  5EGH A;  1AJC A;  3IGY B;  1HQA A;  1URB A;  5TJ3 A;  1ZED A;  2RH6 A;  1B8J A;  1KH7 A;  1ZEB A;  4LRC A;  1ALI A;  2GA3 A;  1Y7A A;  4KJD A;  2XRG A;  4QAX A;  3NKM A;  4LRA A;  3UO0 A;  4LRD A;  3NKQ A;  1EW8 A;  1ZEF A;  4KM4 A;  1Y6V A;  1ELY A;  4LQY A;  3KD8 A;  5L0K A;  3UN2 A;  1E2S P;  5AJ9 A;  4MHX A;  4FDI A;  2GSN A;  1FSU A;  2W5R A;  5L0E A;  4LR7 A;  1K7H A;  2W5W A;  2ZKT A;  4B56 A;  3MK1 A;  1KHN A;  2IUC B;  4KJG A;  4CXK A;  4LRE A;  4ZG9 A;  3BDF A;  1E33 P;  5GOV A;  5IJQ A;  3CMR A;  5HRT A;  3WAW A;  2XR9 A;  4CYR A;  3SZY A;  1EQJ A;  3LXQ A;  4UOO A;  5C66 A;  3TWZ A;  4N7T A;  4UOP A;  3NKN A;  5DLW A;  5DLV A;  1AJA A;  3DPC A;  4UPH A;  3TG0 A;  1E1Z P;  1SHN A;  3TX0 A;  1AJB A;  4LRB A;  5K4P A;  3SZZ A;  1KH5 A;  1N2L A; 
#chains in the Genus database with same CATH topology
 1EJJ A;  1KHJ A;  5IJS A;  4GTX A;  2IUC A;  5LRM A;  1URA A;  1ANI A;  2W5Q A;  3M8Y A;  3OT9 A;  3WAX A;  4KAY A;  1ANJ A;  2GLQ A;  1AUK A;  1HJK A;  2D1G A;  3M8W A;  1N2K A;  2W5V A;  4NWJ A;  4LR8 A;  5EGE A;  3WBH A;  3WAV A;  4MY4 A;  1KH4 A;  5LIA A;  1EW2 A;  1ALK A;  3NKR A;  4ZG7 A;  4UPI A;  4TN0 A;  5L0B A;  3E2D A;  1P49 A;  4YR1 A;  4LR2 A;  3T00 A;  3T01 A;  5LRN A;  1HDH A;  3UN3 A;  1O99 A;  3NVL A;  3UNY A;  5DLT A;  1EI6 A;  4CYS A;  1SHQ A;  1ALH A;  3MK0 A;  3UN5 A;  4UPL A;  3BDG B;  1AJD A;  3WAY A;  1ELZ A;  3M8Z A;  3NKO A;  4KAV A;  3BDH A;  1ELX A;  3IGZ B;  1KHL A;  4CXU A;  4CXS A;  4UPK A;  3ED4 A;  5KXA A;  1KH9 A;  5LQQ A;  1ALJ A;  3IDD A;  4ZG6 A;  5GRR A;  2VQR A;  2G9Y A;  4GTY A;  4ZGA A;  1O98 A;  1KHK A;  3B5Q A;  2W5X A;  2X98 A;  4GTZ A;  2W8S A;  3M7V A;  4FDJ A;  4GTW A;  1E3C P;  3A52 A;  4LR9 A;  2W5T A;  3BDG A;  4UOR A;  2QZU A;  1ED9 A;  2W5S A;  2ANH A;  3Q3Q A;  5INH A;  4LRF A;  1EW9 A;  1ED8 A;  2IFY A;  4MIV A;  4NWX A;  3DYC A;  2GSO A;  3T02 A;  3MK2 A;  3NKP A;  2GSU A;  2W8D A;  5EGH A;  1AJC A;  3IGY B;  1HQA A;  1URB A;  5TJ3 A;  1ZED A;  2RH6 A;  1B8J A;  1KH7 A;  1ZEB A;  4LRC A;  1ALI A;  2GA3 A;  1Y7A A;  4KJD A;  2XRG A;  4QAX A;  3NKM A;  4LRA A;  3UO0 A;  4LRD A;  3NKQ A;  1EW8 A;  1ZEF A;  4KM4 A;  1Y6V A;  1ELY A;  4LQY A;  3KD8 A;  5L0K A;  3UN2 A;  1E2S P;  5AJ9 A;  4MHX A;  4FDI A;  2GSN A;  1FSU A;  2W5R A;  5L0E A;  4LR7 A;  1K7H A;  2W5W A;  2ZKT A;  4B56 A;  3MK1 A;  1KHN A;  2IUC B;  4KJG A;  4CXK A;  4LRE A;  4ZG9 A;  3BDF A;  1E33 P;  5GOV A;  5IJQ A;  3CMR A;  5HRT A;  3WAW A;  2XR9 A;  4CYR A;  3SZY A;  1EQJ A;  3LXQ A;  4UOO A;  5C66 A;  3TWZ A;  4N7T A;  4UOP A;  3NKN A;  5DLW A;  5DLV A;  1AJA A;  3DPC A;  4UPH A;  3TG0 A;  1E1Z P;  1SHN A;  3TX0 A;  1AJB A;  4LRB A;  5K4P A;  3SZZ A;  1KH5 A;  1N2L A; 
#chains in the Genus database with same CATH homology
 1EJJ A;  1KHJ A;  5IJS A;  4GTX A;  2IUC A;  5LRM A;  1URA A;  1ANI A;  2W5Q A;  3M8Y A;  3OT9 A;  3WAX A;  4KAY A;  1ANJ A;  2GLQ A;  1AUK A;  1HJK A;  2D1G A;  3M8W A;  1N2K A;  2W5V A;  4NWJ A;  4LR8 A;  5EGE A;  3WBH A;  3WAV A;  4MY4 A;  1KH4 A;  5LIA A;  1EW2 A;  1ALK A;  3NKR A;  4ZG7 A;  4UPI A;  4TN0 A;  5L0B A;  3E2D A;  1P49 A;  4YR1 A;  4LR2 A;  3T00 A;  3T01 A;  5LRN A;  1HDH A;  3UN3 A;  1O99 A;  3NVL A;  3UNY A;  5DLT A;  1EI6 A;  4CYS A;  1SHQ A;  1ALH A;  3MK0 A;  3UN5 A;  4UPL A;  3BDG B;  1AJD A;  3WAY A;  1ELZ A;  3M8Z A;  3NKO A;  4KAV A;  3BDH A;  1ELX A;  3IGZ B;  1KHL A;  4CXU A;  4CXS A;  4UPK A;  3ED4 A;  5KXA A;  1KH9 A;  5LQQ A;  1ALJ A;  3IDD A;  4ZG6 A;  5GRR A;  2VQR A;  2G9Y A;  4GTY A;  4ZGA A;  1O98 A;  1KHK A;  3B5Q A;  2W5X A;  2X98 A;  4GTZ A;  2W8S A;  3M7V A;  4FDJ A;  4GTW A;  1E3C P;  3A52 A;  4LR9 A;  2W5T A;  3BDG A;  4UOR A;  2QZU A;  1ED9 A;  2W5S A;  2ANH A;  3Q3Q A;  5INH A;  4LRF A;  1EW9 A;  1ED8 A;  2IFY A;  4MIV A;  4NWX A;  3DYC A;  2GSO A;  3T02 A;  3MK2 A;  3NKP A;  2GSU A;  2W8D A;  5EGH A;  1AJC A;  3IGY B;  1HQA A;  1URB A;  5TJ3 A;  1ZED A;  2RH6 A;  1B8J A;  1KH7 A;  1ZEB A;  4LRC A;  1ALI A;  2GA3 A;  1Y7A A;  4KJD A;  2XRG A;  4QAX A;  3NKM A;  4LRA A;  3UO0 A;  4LRD A;  3NKQ A;  1EW8 A;  1ZEF A;  4KM4 A;  1Y6V A;  1ELY A;  4LQY A;  3KD8 A;  5L0K A;  3UN2 A;  1E2S P;  5AJ9 A;  4MHX A;  4FDI A;  2GSN A;  1FSU A;  2W5R A;  5L0E A;  4LR7 A;  1K7H A;  2W5W A;  2ZKT A;  4B56 A;  3MK1 A;  1KHN A;  2IUC B;  4KJG A;  4CXK A;  4LRE A;  4ZG9 A;  3BDF A;  1E33 P;  5GOV A;  5IJQ A;  3CMR A;  5HRT A;  3WAW A;  2XR9 A;  4CYR A;  3SZY A;  1EQJ A;  3LXQ A;  4UOO A;  5C66 A;  3TWZ A;  4N7T A;  4UOP A;  3NKN A;  5DLW A;  5DLV A;  1AJA A;  3DPC A;  4UPH A;  3TG0 A;  1E1Z P;  1SHN A;  3TX0 A;  1AJB A;  4LRB A;  5K4P A;  3SZZ A;  1KH5 A;  1N2L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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