2ANHA

Alkaline phosphatase (d153h)
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
446
structure length
446
Chain Sequence
b'MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
total genus 164
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-09-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2anhA00
5L0BA 1KHJA 4NWXA 1HDHA 3M8ZA 3B5QA 4KM4A 1ALJA 4CXKA 1ED8A 4UPKA 3T01A 1KH7A 3NKQA 5IJQA 4LRBA 3T02A 4ZG7A 1KHKA 4KJGA 1ELXA 2W5RA 4UORA 1AJBA 4N7TA 3TX0A 5GRRA 4LRAA 5C66A 1EI6A 1O99A 3NKPA 4UOPA 2IFYA 1ANIA 3BDFA 4LR7A 1E3CP 4TN0A 4ZG6A 2GSOA 1E2SP 3IGYB 2GSNA 4GTXA 3NKNA 3TWZA 3WAVA 4LR9A 5TJ3A 4GTZA 4UPLA 3NKRA 1ALKA 5GOVA 2W5VA 1KH5A 4NWJA 1ZEBA 3OT9A 1ALHA 4MY4A 3UN3A 2XRGA 1ELZA 4LRCA 1AJCA 3MK0A 3SZYA 3IGZB 3KD8A 2G9YA 5DLTA 4LR2A 1E1ZP 1EJJA 2XR9A 4CYSA 3NKMA 2D1GA 1ED9A 2GLQA 1SHNA 3T00A 2W5SA 3E2DA 5LQQA 1P49A 1EW2A 4UOOA 4FDIA 5IJSA 5KXAA 1E33P 1K7HA 4LR8A 4MHXA 2ANHA 3M8WA 3MK2A 3MK1A 4LRFA 1KH9A 2X98A 3WAYA 3UN2A 1N2KA 3DPCA 1KHNA 4YR1A 4UPHA 5INHA 3M8YA 2W8SA 2ZKTA 3NVLA 3CMRA 4FDJA 3WBHA 4MIVA 1KHLA 2W5QA 5EGEA 5LRMA 1EW8A 2W8DA 3DYCA 1Y7AA 3BDGA 1EW9A 1URBA 2VQRA 2IUCA 1N2LA 5L0EA 1Y6VA 3ED4A 4B56A 1ZEDA 1AUKA 2W5TA 4KAYA 2GA3A 4ZG9A 5DLVA 5HRTA 4LQYA 5EGHA 5LRNA 4ZGAA 1EQJA 3LXQA 1ELYA 1URAA 4GTYA 1AJAA 4LRDA 3A52A 4UPIA 5DLWA 1AJDA 2W5WA 3SZZA 3UN5A 3WAXA 1ZEFA 4GTWA 3BDGB 5LIAA 1ALIA 2IUCB 4KAVA 1SHQA 2GSUA 4LREA 3M7VA 4QAXA 5K4PA 4CXUA 2QZUA 1ANJA 3NKOA 4KJDA 5AJ9A 3UNYA 5L0KA 4CXSA 1HQAA 3IDDA 4CYRA 3TG0A 3Q3QA 3WAWA 1HJKA 1B8JA 1FSUA 3UO0A 2W5XA 3BDHA 1KH4A 1O98A 2RH6A
chains in the Genus database with same CATH superfamily
5L0BA 1KHJA 4NWXA 1HDHA 3M8ZA 3B5QA 4KM4A 1ALJA 4CXKA 1ED8A 4UPKA 3T01A 1KH7A 3NKQA 5IJQA 4LRBA 3T02A 4ZG7A 1KHKA 4KJGA 1ELXA 2W5RA 4UORA 1AJBA 4N7TA 3TX0A 5GRRA 4LRAA 5C66A 1EI6A 1O99A 3NKPA 4UOPA 2IFYA 1ANIA 3BDFA 4LR7A 1E3CP 4TN0A 4ZG6A 2GSOA 1E2SP 3IGYB 2GSNA 4GTXA 3NKNA 3TWZA 3WAVA 4LR9A 5TJ3A 4GTZA 4UPLA 3NKRA 1ALKA 5GOVA 2W5VA 1KH5A 4NWJA 1ZEBA 3OT9A 1ALHA 4MY4A 3UN3A 2XRGA 1ELZA 4LRCA 1AJCA 3MK0A 3SZYA 3IGZB 3KD8A 2G9YA 5DLTA 4LR2A 1E1ZP 1EJJA 2XR9A 4CYSA 3NKMA 2D1GA 1ED9A 2GLQA 1SHNA 3T00A 2W5SA 3E2DA 5LQQA 1P49A 1EW2A 4UOOA 4FDIA 5IJSA 5KXAA 1E33P 1K7HA 4LR8A 4MHXA 2ANHA 3M8WA 3MK2A 3MK1A 4LRFA 1KH9A 2X98A 3WAYA 3UN2A 1N2KA 3DPCA 1KHNA 4YR1A 4UPHA 5INHA 3M8YA 2W8SA 2ZKTA 3NVLA 3CMRA 4FDJA 3WBHA 4MIVA 1KHLA 2W5QA 5EGEA 5LRMA 1EW8A 2W8DA 3DYCA 1Y7AA 3BDGA 1EW9A 1URBA 2VQRA 2IUCA 1N2LA 5L0EA 1Y6VA 3ED4A 4B56A 1ZEDA 1AUKA 2W5TA 4KAYA 2GA3A 4ZG9A 5DLVA 5HRTA 4LQYA 5EGHA 5LRNA 4ZGAA 1EQJA 3LXQA 1ELYA 1URAA 4GTYA 1AJAA 4LRDA 3A52A 4UPIA 5DLWA 1AJDA 2W5WA 3SZZA 3UN5A 3WAXA 1ZEFA 4GTWA 3BDGB 5LIAA 1ALIA 2IUCB 4KAVA 1SHQA 2GSUA 4LREA 3M7VA 4QAXA 5K4PA 4CXUA 2QZUA 1ANJA 3NKOA 4KJDA 5AJ9A 3UNYA 5L0KA 4CXSA 1HQAA 3IDDA 4CYRA 3TG0A 3Q3QA 3WAWA 1HJKA 1B8JA 1FSUA 3UO0A 2W5XA 3BDHA 1KH4A 1O98A 2RH6A
chains in the Genus database with same CATH topology
5L0BA 1KHJA 4NWXA 1HDHA 3M8ZA 3B5QA 4KM4A 1ALJA 4CXKA 1ED8A 4UPKA 3T01A 1KH7A 3NKQA 5IJQA 4LRBA 3T02A 4ZG7A 1KHKA 4KJGA 1ELXA 2W5RA 4UORA 1AJBA 4N7TA 3TX0A 5GRRA 4LRAA 5C66A 1EI6A 1O99A 3NKPA 4UOPA 2IFYA 1ANIA 3BDFA 4LR7A 1E3CP 4TN0A 4ZG6A 2GSOA 1E2SP 3IGYB 2GSNA 4GTXA 3NKNA 3TWZA 3WAVA 4LR9A 5TJ3A 4GTZA 4UPLA 3NKRA 1ALKA 5GOVA 2W5VA 1KH5A 4NWJA 1ZEBA 3OT9A 1ALHA 4MY4A 3UN3A 2XRGA 1ELZA 4LRCA 1AJCA 3MK0A 3SZYA 3IGZB 3KD8A 2G9YA 5DLTA 4LR2A 1E1ZP 1EJJA 2XR9A 4CYSA 3NKMA 2D1GA 1ED9A 2GLQA 1SHNA 3T00A 2W5SA 3E2DA 5LQQA 1P49A 1EW2A 4UOOA 4FDIA 5IJSA 5KXAA 1E33P 1K7HA 4LR8A 4MHXA 2ANHA 3M8WA 3MK2A 3MK1A 4LRFA 1KH9A 2X98A 3WAYA 3UN2A 1N2KA 3DPCA 1KHNA 4YR1A 4UPHA 5INHA 3M8YA 2W8SA 2ZKTA 3NVLA 3CMRA 4FDJA 3WBHA 4MIVA 1KHLA 2W5QA 5EGEA 5LRMA 1EW8A 2W8DA 3DYCA 1Y7AA 3BDGA 1EW9A 1URBA 2VQRA 2IUCA 1N2LA 5L0EA 1Y6VA 3ED4A 4B56A 1ZEDA 1AUKA 2W5TA 4KAYA 2GA3A 4ZG9A 5DLVA 5HRTA 4LQYA 5EGHA 5LRNA 4ZGAA 1EQJA 3LXQA 1ELYA 1URAA 4GTYA 1AJAA 4LRDA 3A52A 4UPIA 5DLWA 1AJDA 2W5WA 3SZZA 3UN5A 3WAXA 1ZEFA 4GTWA 3BDGB 5LIAA 1ALIA 2IUCB 4KAVA 1SHQA 2GSUA 4LREA 3M7VA 4QAXA 5K4PA 4CXUA 2QZUA 1ANJA 3NKOA 4KJDA 5AJ9A 3UNYA 5L0KA 4CXSA 1HQAA 3IDDA 4CYRA 3TG0A 3Q3QA 3WAWA 1HJKA 1B8JA 1FSUA 3UO0A 2W5XA 3BDHA 1KH4A 1O98A 2RH6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L0B A;  1KHJ A;  4NWX A;  1HDH A;  3M8Z A;  3B5Q A;  4KM4 A;  1ALJ A;  4CXK A;  1ED8 A;  4UPK A;  3T01 A;  1KH7 A;  3NKQ A;  5IJQ A;  4LRB A;  3T02 A;  4ZG7 A;  1KHK A;  4KJG A;  1ELX A;  2W5R A;  4UOR A;  1AJB A;  4N7T A;  3TX0 A;  5GRR A;  4LRA A;  5C66 A;  1EI6 A;  1O99 A;  3NKP A;  4UOP A;  2IFY A;  1ANI A;  3BDF A;  4LR7 A;  1E3C P;  4TN0 A;  4ZG6 A;  2GSO A;  1E2S P;  3IGY B;  2GSN A;  4GTX A;  3NKN A;  3TWZ A;  3WAV A;  4LR9 A;  5TJ3 A;  4GTZ A;  4UPL A;  3NKR A;  1ALK A;  5GOV A;  2W5V A;  1KH5 A;  4NWJ A;  1ZEB A;  3OT9 A;  1ALH A;  4MY4 A;  3UN3 A;  2XRG A;  1ELZ A;  4LRC A;  1AJC A;  3MK0 A;  3SZY A;  3IGZ B;  3KD8 A;  2G9Y A;  5DLT A;  4LR2 A;  1E1Z P;  1EJJ A;  2XR9 A;  4CYS A;  3NKM A;  2D1G A;  1ED9 A;  2GLQ A;  1SHN A;  3T00 A;  2W5S A;  3E2D A;  5LQQ A;  1P49 A;  1EW2 A;  4UOO A;  4FDI A;  5IJS A;  5KXA A;  1E33 P;  1K7H A;  4LR8 A;  4MHX A;  2ANH A;  3M8W A;  3MK2 A;  3MK1 A;  4LRF A;  1KH9 A;  2X98 A;  3WAY A;  3UN2 A;  1N2K A;  3DPC A;  1KHN A;  4YR1 A;  4UPH A;  5INH A;  3M8Y A;  2W8S A;  2ZKT A;  3NVL A;  3CMR A;  4FDJ A;  3WBH A;  4MIV A;  1KHL A;  2W5Q A;  5EGE A;  5LRM A;  1EW8 A;  2W8D A;  3DYC A;  1Y7A A;  3BDG A;  1EW9 A;  1URB A;  2VQR A;  2IUC A;  1N2L A;  5L0E A;  1Y6V A;  3ED4 A;  4B56 A;  1ZED A;  1AUK A;  2W5T A;  4KAY A;  2GA3 A;  4ZG9 A;  5DLV A;  5HRT A;  4LQY A;  5EGH A;  5LRN A;  4ZGA A;  1EQJ A;  3LXQ A;  1ELY A;  1URA A;  4GTY A;  1AJA A;  4LRD A;  3A52 A;  4UPI A;  5DLW A;  1AJD A;  2W5W A;  3SZZ A;  3UN5 A;  3WAX A;  1ZEF A;  4GTW A;  3BDG B;  5LIA A;  1ALI A;  2IUC B;  4KAV A;  1SHQ A;  2GSU A;  4LRE A;  3M7V A;  4QAX A;  5K4P A;  4CXU A;  2QZU A;  1ANJ A;  3NKO A;  4KJD A;  5AJ9 A;  3UNY A;  5L0K A;  4CXS A;  1HQA A;  3IDD A;  4CYR A;  3TG0 A;  3Q3Q A;  3WAW A;  1HJK A;  1B8J A;  1FSU A;  3UO0 A;  2W5X A;  3BDH A;  1KH4 A;  1O98 A;  2RH6 A; 
#chains in the Genus database with same CATH topology
 5L0B A;  1KHJ A;  4NWX A;  1HDH A;  3M8Z A;  3B5Q A;  4KM4 A;  1ALJ A;  4CXK A;  1ED8 A;  4UPK A;  3T01 A;  1KH7 A;  3NKQ A;  5IJQ A;  4LRB A;  3T02 A;  4ZG7 A;  1KHK A;  4KJG A;  1ELX A;  2W5R A;  4UOR A;  1AJB A;  4N7T A;  3TX0 A;  5GRR A;  4LRA A;  5C66 A;  1EI6 A;  1O99 A;  3NKP A;  4UOP A;  2IFY A;  1ANI A;  3BDF A;  4LR7 A;  1E3C P;  4TN0 A;  4ZG6 A;  2GSO A;  1E2S P;  3IGY B;  2GSN A;  4GTX A;  3NKN A;  3TWZ A;  3WAV A;  4LR9 A;  5TJ3 A;  4GTZ A;  4UPL A;  3NKR A;  1ALK A;  5GOV A;  2W5V A;  1KH5 A;  4NWJ A;  1ZEB A;  3OT9 A;  1ALH A;  4MY4 A;  3UN3 A;  2XRG A;  1ELZ A;  4LRC A;  1AJC A;  3MK0 A;  3SZY A;  3IGZ B;  3KD8 A;  2G9Y A;  5DLT A;  4LR2 A;  1E1Z P;  1EJJ A;  2XR9 A;  4CYS A;  3NKM A;  2D1G A;  1ED9 A;  2GLQ A;  1SHN A;  3T00 A;  2W5S A;  3E2D A;  5LQQ A;  1P49 A;  1EW2 A;  4UOO A;  4FDI A;  5IJS A;  5KXA A;  1E33 P;  1K7H A;  4LR8 A;  4MHX A;  2ANH A;  3M8W A;  3MK2 A;  3MK1 A;  4LRF A;  1KH9 A;  2X98 A;  3WAY A;  3UN2 A;  1N2K A;  3DPC A;  1KHN A;  4YR1 A;  4UPH A;  5INH A;  3M8Y A;  2W8S A;  2ZKT A;  3NVL A;  3CMR A;  4FDJ A;  3WBH A;  4MIV A;  1KHL A;  2W5Q A;  5EGE A;  5LRM A;  1EW8 A;  2W8D A;  3DYC A;  1Y7A A;  3BDG A;  1EW9 A;  1URB A;  2VQR A;  2IUC A;  1N2L A;  5L0E A;  1Y6V A;  3ED4 A;  4B56 A;  1ZED A;  1AUK A;  2W5T A;  4KAY A;  2GA3 A;  4ZG9 A;  5DLV A;  5HRT A;  4LQY A;  5EGH A;  5LRN A;  4ZGA A;  1EQJ A;  3LXQ A;  1ELY A;  1URA A;  4GTY A;  1AJA A;  4LRD A;  3A52 A;  4UPI A;  5DLW A;  1AJD A;  2W5W A;  3SZZ A;  3UN5 A;  3WAX A;  1ZEF A;  4GTW A;  3BDG B;  5LIA A;  1ALI A;  2IUC B;  4KAV A;  1SHQ A;  2GSU A;  4LRE A;  3M7V A;  4QAX A;  5K4P A;  4CXU A;  2QZU A;  1ANJ A;  3NKO A;  4KJD A;  5AJ9 A;  3UNY A;  5L0K A;  4CXS A;  1HQA A;  3IDD A;  4CYR A;  3TG0 A;  3Q3Q A;  3WAW A;  1HJK A;  1B8J A;  1FSU A;  3UO0 A;  2W5X A;  3BDH A;  1KH4 A;  1O98 A;  2RH6 A; 
#chains in the Genus database with same CATH homology
 5L0B A;  1KHJ A;  4NWX A;  1HDH A;  3M8Z A;  3B5Q A;  4KM4 A;  1ALJ A;  4CXK A;  1ED8 A;  4UPK A;  3T01 A;  1KH7 A;  3NKQ A;  5IJQ A;  4LRB A;  3T02 A;  4ZG7 A;  1KHK A;  4KJG A;  1ELX A;  2W5R A;  4UOR A;  1AJB A;  4N7T A;  3TX0 A;  5GRR A;  4LRA A;  5C66 A;  1EI6 A;  1O99 A;  3NKP A;  4UOP A;  2IFY A;  1ANI A;  3BDF A;  4LR7 A;  1E3C P;  4TN0 A;  4ZG6 A;  2GSO A;  1E2S P;  3IGY B;  2GSN A;  4GTX A;  3NKN A;  3TWZ A;  3WAV A;  4LR9 A;  5TJ3 A;  4GTZ A;  4UPL A;  3NKR A;  1ALK A;  5GOV A;  2W5V A;  1KH5 A;  4NWJ A;  1ZEB A;  3OT9 A;  1ALH A;  4MY4 A;  3UN3 A;  2XRG A;  1ELZ A;  4LRC A;  1AJC A;  3MK0 A;  3SZY A;  3IGZ B;  3KD8 A;  2G9Y A;  5DLT A;  4LR2 A;  1E1Z P;  1EJJ A;  2XR9 A;  4CYS A;  3NKM A;  2D1G A;  1ED9 A;  2GLQ A;  1SHN A;  3T00 A;  2W5S A;  3E2D A;  5LQQ A;  1P49 A;  1EW2 A;  4UOO A;  4FDI A;  5IJS A;  5KXA A;  1E33 P;  1K7H A;  4LR8 A;  4MHX A;  2ANH A;  3M8W A;  3MK2 A;  3MK1 A;  4LRF A;  1KH9 A;  2X98 A;  3WAY A;  3UN2 A;  1N2K A;  3DPC A;  1KHN A;  4YR1 A;  4UPH A;  5INH A;  3M8Y A;  2W8S A;  2ZKT A;  3NVL A;  3CMR A;  4FDJ A;  3WBH A;  4MIV A;  1KHL A;  2W5Q A;  5EGE A;  5LRM A;  1EW8 A;  2W8D A;  3DYC A;  1Y7A A;  3BDG A;  1EW9 A;  1URB A;  2VQR A;  2IUC A;  1N2L A;  5L0E A;  1Y6V A;  3ED4 A;  4B56 A;  1ZED A;  1AUK A;  2W5T A;  4KAY A;  2GA3 A;  4ZG9 A;  5DLV A;  5HRT A;  4LQY A;  5EGH A;  5LRN A;  4ZGA A;  1EQJ A;  3LXQ A;  1ELY A;  1URA A;  4GTY A;  1AJA A;  4LRD A;  3A52 A;  4UPI A;  5DLW A;  1AJD A;  2W5W A;  3SZZ A;  3UN5 A;  3WAX A;  1ZEF A;  4GTW A;  3BDG B;  5LIA A;  1ALI A;  2IUC B;  4KAV A;  1SHQ A;  2GSU A;  4LRE A;  3M7V A;  4QAX A;  5K4P A;  4CXU A;  2QZU A;  1ANJ A;  3NKO A;  4KJD A;  5AJ9 A;  3UNY A;  5L0K A;  4CXS A;  1HQA A;  3IDD A;  4CYR A;  3TG0 A;  3Q3Q A;  3WAW A;  1HJK A;  1B8J A;  1FSU A;  3UO0 A;  2W5X A;  3BDH A;  1KH4 A;  1O98 A;  2RH6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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