2AQ7A

Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(r)-isoprene unit is required for activity against the condensing enzymes from mycobacterium tuberculosis and escherichia coli
Total Genus 144
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
sequence length
404
structure length
404
Chain Sequence
MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLIDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli
pubmed doi rcsb
molecule tags Transferase
source organism Escherichia coli
molecule keywords 3-oxoacyl-[acyl-carrier-protein] synthase I
total genus 144
structure length 404
sequence length 404
chains with identical sequence B, C, D
ec nomenclature ec 2.3.1.41: Beta-ketoacyl-[acyl-carrier-protein] synthase I.
pdb deposition date 2005-08-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00109 ketoacyl-synt Beta-ketoacyl synthase, N-terminal domain
A PF02801 Ketoacyl-synt_C Beta-ketoacyl synthase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.47.10 Alpha Beta 3-Layer(aba) Sandwich Peroxisomal Thiolase; Chain A, domain 1 Peroxisomal Thiolase; Chain A, domain 1 2aq7A01
3.40.47.10 Alpha Beta 3-Layer(aba) Sandwich Peroxisomal Thiolase; Chain A, domain 1 Peroxisomal Thiolase; Chain A, domain 1 2aq7A02
3T6SB 4XL3A 2WL6A 5CBQA 1TEDA 4C6VA 2D52A 4U4EA 1I86A 1ZOWA 1NL7A 4X0OD 3V7IA 2ALMA 1I88A 2HDBA 2IIKA 1MZJA 4JB6A 4C2JA 4OQJA 3S20A 1U0WA 3U0FA 3MQDA 4KTIA 5AB6A 2WKTA 1U6SA 3E1HA 1DM3A 4X9KA 2WL4C 2WKTC 4JV3A 4OPFA 3IL6A 3OV3A 4QYRA 1OXHA 5BQSA 1M3ZA 2QX1A 2IBUA 3IL9A 3G11A 4KC5A 4X0OA 4UBWA 3SVKA 5AB4A 1XESA 4YLTA 3FK5A 4EWGA 2IWZA 4ZRCA 2IB9A 1XPKA 3OYTA 4EFIA 1U0VA 1WDMC 3LEHA 2GFWA 3HO2A 3S3LA 1XPKC 2BZ4A 2WKVA 1H4FA 3A5SA 1WL4A 2C7ZA 3T6SA 4JRHA 5HWQA 1M1OA 2WUAA 1M4SA 3S1ZA 1AFWA 2F82A 2HG4A 1EE0A 1ULQA 4WYSA 2VTZA 2BYWA 4ZDNA 4LS6A 3WD8A 3EUQA 3S23A 4C6XA 4F32A 4EGVA 4XL4A 1X9EA 2IB7A 2BYXA 4JPFA 3IL5A 3O04A 3KZUA 4OPEA 3A5QA 4YJYA 4C71A 4DDOA 2GYOA 4KU5A 1D6HA 4C6WA 4V2PA 1I89A 1UB7A 3OITA 5KP5A 1TQYB 5BZ4A 1U0UA 1Z1FA 1WDLC 2VZ8A 3VS8A 2VB9A 2FA0A 3HNZA 1FJ4A 2C9HA 2BYZA 1M1MA 4KU3A 2FA3A 4XSAA 5HWPA 3SQZA 3VS9A 2GFXA 1DD8A 2VU2A 3IL7A 4C2KA 2WL4A 5KP2A 4LS7A 4JATA 2RJTA 2IB8A 4C6ZA 2WU9A 1PXTA 4E1LA 4UBUA 4YUFA 4N45A 1U0MA 5AB7A 5KP6A 4NA3A 2VBAA 3G0YA 4LS5A 5BY7A 4JAOA 4C70A 1YSLA 2IBWA 4NZSA 4WYRA 1M1TA 4B3HC 2VU0A 4LS8A 3WXYA 1HNKA 2WGEA 5KP7A 4UBTA 1E5MA 4KTMA 3TSYA 4Z19A 3GWAA 3ZBKA 2EBDA 1M4TA 4JAQA 2QO3A 2VZ9A 5LOTA 4NA2A 1HNDA 2D3MA 5AB5A 1OX0A 5LNQA 2QNZA 3S21A 3EUOA 2D3TC 4NA1A 5HWRA 4JAPA 3I8PA 5F38B 2IBYA 1TEEA 2GP6A 5LD8A 4WKYA 2IWYA 4YUCA 4WZUA 3ROWA 4Z37A 1DLVA 4W61A 4XSBA 2AQBA 1HNJA 2VB8A 1EBLA 1XPLA 1WDKC 1XPMA 1Z1EA 5BNMA 4WUMA 4QAVA 1BI5A 1D6IA 3WXZA 5F0VA 2VU1A 2WGDA 3EUTA 4JARA 4C73A 4R8EA 2AQ7A 4YXTA 1B3NA 4B3IC 5F38D 3GOAA 1KASA 2QO1A 1CGKA 2QO0A 4O9AA 4NHDA 2VB7A 4B7VA 2C7YA 1CHWA 3V4XA 4O9CA 2VB7C 1HNHA 5E5NA 4C6UA 3IL4A 1XETA 1M3KA 2BYYA 2GQDA 4C72A 2BUHA 2BUIA 3LEDA 2GFYA 4YXQA 4TKTA 4BIAA 5LP7A 3IL3A 3AWKA 2BZ3A 2D51A 4UBVA 4XS9A 4RYBA 1MZSA 5F38A 4EWPA 3GWEA 4YXVA 5F38C 4XOXA 3T5YB 2GFVA 5SXOA 3H76A 4XS7A 3WY0A 2UV8A 1FJ8A 1G5XA 2WGFA 3ALEA 1WL5A 1W0IA 3H77A 1TVZA 1U6EA 4B3JC 1QFLA 1TQYA 2EFTA 4YZOA 1TXTA 2QNXA 5BNSA 3WD7A 2WKUA 4X9OA 3ZBNA 1J3NA 5C1JA 4Z8DA 2X3EA 3AWJA 2AHBA 3H78A 3ZBLA 2P8UA 2IX4A 4JRMA 3HO9A 5TT4A 3A5RA 4JGAA 2AJ9A 1CGZA 3SS6A 4DFEA 1DLUA 4O99A 4B0NA 2WL4B 4KU2A 5HWOA 4JD3A 3T8EA 3E60A 4BI9A 2WGGA 3ZBGA 1BQ6A 2H84A 1QLVA 1HZPA 2QNYA 1HN9A 1CMLA 2WL5A 5BYVA 1OU6A 3LRFA 2P0UA 4XL2A 3T5YA 2WL5C 1F91A 5KP8A 3V4NA 1YSLB 3OV2A 5DWZC 1I8BA 2WL4D 4DD5A 1D6FA 3U0EA 4N44A 2WYAA 1JWXA 2F2SA 2F9AA 5BNRA 3HHDA 1EK4A
chains in the Genus database with same CATH superfamily
3T6SB 4XL3A 2WL6A 5CBQA 1TEDA 4C6VA 2D52A 4U4EA 1I86A 1ZOWA 1NL7A 4X0OD 3V7IA 2ALMA 1I88A 2HDBA 2IIKA 1MZJA 4JB6A 4C2JA 4OQJA 3S20A 1U0WA 3U0FA 3MQDA 4KTIA 5AB6A 2WKTA 1U6SA 3E1HA 1DM3A 4X9KA 2WL4C 2WKTC 4JV3A 4OPFA 3IL6A 3OV3A 4QYRA 1OXHA 5BQSA 1M3ZA 2QX1A 2IBUA 3IL9A 3G11A 4KC5A 4X0OA 4UBWA 3SVKA 5AB4A 1XESA 4YLTA 3FK5A 4EWGA 2IWZA 4ZRCA 2IB9A 1XPKA 3OYTA 4EFIA 1U0VA 1WDMC 3LEHA 2GFWA 3HO2A 3S3LA 1XPKC 2BZ4A 2WKVA 1H4FA 3A5SA 1WL4A 2C7ZA 3T6SA 4JRHA 5HWQA 1M1OA 2WUAA 1M4SA 3S1ZA 1AFWA 2F82A 2HG4A 1EE0A 1ULQA 4WYSA 2VTZA 2BYWA 4ZDNA 4LS6A 3WD8A 3EUQA 3S23A 4C6XA 4F32A 4EGVA 4XL4A 1X9EA 2IB7A 2BYXA 4JPFA 3IL5A 3O04A 3KZUA 4OPEA 3A5QA 4YJYA 4C71A 4DDOA 2GYOA 4KU5A 1D6HA 4C6WA 4V2PA 1I89A 1UB7A 3OITA 5KP5A 1TQYB 5BZ4A 1U0UA 1Z1FA 1WDLC 2VZ8A 3VS8A 2VB9A 2FA0A 3HNZA 1FJ4A 2C9HA 2BYZA 1M1MA 4KU3A 2FA3A 4XSAA 5HWPA 3SQZA 3VS9A 2GFXA 1DD8A 2VU2A 3IL7A 4C2KA 2WL4A 5KP2A 4LS7A 4JATA 2RJTA 2IB8A 4C6ZA 2WU9A 1PXTA 4E1LA 4UBUA 4YUFA 4N45A 1U0MA 5AB7A 5KP6A 4NA3A 2VBAA 3G0YA 4LS5A 5BY7A 4JAOA 4C70A 1YSLA 2IBWA 4NZSA 4WYRA 1M1TA 4B3HC 2VU0A 4LS8A 3WXYA 1HNKA 2WGEA 5KP7A 4UBTA 1E5MA 4KTMA 3TSYA 4Z19A 3GWAA 3ZBKA 2EBDA 1M4TA 4JAQA 2QO3A 2VZ9A 5LOTA 4NA2A 1HNDA 2D3MA 5AB5A 1OX0A 5LNQA 2QNZA 3S21A 3EUOA 2D3TC 4NA1A 5HWRA 4JAPA 3I8PA 5F38B 2IBYA 1TEEA 2GP6A 5LD8A 4WKYA 2IWYA 4YUCA 4WZUA 3ROWA 4Z37A 1DLVA 4W61A 4XSBA 2AQBA 1HNJA 2VB8A 1EBLA 1XPLA 1WDKC 1XPMA 1Z1EA 5BNMA 4WUMA 4QAVA 1BI5A 1D6IA 3WXZA 5F0VA 2VU1A 2WGDA 3EUTA 4JARA 4C73A 4R8EA 2AQ7A 4YXTA 1B3NA 4B3IC 5F38D 3GOAA 1KASA 2QO1A 1CGKA 2QO0A 3LMAA 4O9AA 4NHDA 2VB7A 4B7VA 2C7YA 1CHWA 3V4XA 4O9CA 2VB7C 1HNHA 5E5NA 4C6UA 3IL4A 1XETA 1M3KA 2BYYA 2GQDA 4C72A 2BUHA 2BUIA 3LEDA 2GFYA 4YXQA 4TKTA 4BIAA 5LP7A 3IL3A 3AWKA 2BZ3A 2D51A 4UBVA 4XS9A 4RYBA 1MZSA 5F38A 4EWPA 3GWEA 4YXVA 5F38C 4XOXA 3T5YB 2GFVA 5SXOA 3H76A 4XS7A 3WY0A 2UV8A 1FJ8A 1G5XA 2WGFA 3ALEA 1WL5A 1W0IA 3LM6A 3H77A 1TVZA 1U6EA 4B3JC 1QFLA 1TQYA 2EFTA 4YZOA 1TXTA 2QNXA 5BNSA 3WD7A 2WKUA 4X9OA 3ZBNA 1J3NA 5C1JA 4Z8DA 2X3EA 3AWJA 2AHBA 3H78A 3ZBLA 2P8UA 2IX4A 4JRMA 3HO9A 5TT4A 3A5RA 4JGAA 2AJ9A 1CGZA 3SS6A 4DFEA 1DLUA 4O99A 4B0NA 2WL4B 4KU2A 5HWOA 4JD3A 3T8EA 3E60A 4BI9A 2WGGA 3ZBGA 1BQ6A 2H84A 1QLVA 1HZPA 2QNYA 1HN9A 1CMLA 2WL5A 5BYVA 1OU6A 3LRFA 2P0UA 4XL2A 3T5YA 2WL5C 1F91A 5KP8A 3V4NA 1YSLB 3OV2A 5DWZC 1I8BA 2WL4D 4DD5A 1D6FA 3U0EA 4N44A 2WYAA 1JWXA 2F2SA 2F9AA 5BNRA 3HHDA 1EK4A
chains in the Genus database with same CATH topology
3T6SB 4XL3A 2WL6A 5CBQA 1TEDA 4C6VA 2D52A 4U4EA 1I86A 1ZOWA 1NL7A 4X0OD 3V7IA 2ALMA 1I88A 2HDBA 2IIKA 1MZJA 4JB6A 4C2JA 4OQJA 3S20A 1U0WA 3U0FA 3MQDA 4KTIA 5AB6A 2WKTA 1U6SA 3E1HA 1DM3A 4X9KA 2WL4C 2WKTC 4JV3A 4OPFA 3IL6A 3OV3A 4QYRA 1OXHA 5BQSA 1M3ZA 2QX1A 2IBUA 3IL9A 3G11A 4KC5A 4X0OA 4UBWA 3SVKA 5AB4A 1XESA 4YLTA 3FK5A 4EWGA 2IWZA 4ZRCA 2IB9A 1XPKA 3OYTA 4EFIA 1U0VA 1WDMC 3LEHA 2GFWA 3HO2A 3S3LA 1XPKC 2BZ4A 2WKVA 1H4FA 3A5SA 1WL4A 2C7ZA 3T6SA 4JRHA 5HWQA 1M1OA 2WUAA 1M4SA 3S1ZA 1AFWA 2F82A 2HG4A 1EE0A 1ULQA 4WYSA 2VTZA 2BYWA 4ZDNA 4LS6A 3WD8A 3EUQA 3S23A 4C6XA 4F32A 4EGVA 4XL4A 1X9EA 2IB7A 2BYXA 4JPFA 3IL5A 3O04A 3KZUA 4OPEA 3A5QA 4YJYA 4C71A 4DDOA 2GYOA 4KU5A 1D6HA 4C6WA 4V2PA 1I89A 1UB7A 3OITA 5KP5A 1TQYB 5BZ4A 1U0UA 1Z1FA 1WDLC 2VZ8A 3VS8A 2VB9A 2FA0A 3HNZA 1FJ4A 2C9HA 2BYZA 1M1MA 4KU3A 2FA3A 4XSAA 5HWPA 3SQZA 3VS9A 2GFXA 1DD8A 2VU2A 3IL7A 4C2KA 2WL4A 5KP2A 4LS7A 4JATA 2RJTA 2IB8A 4C6ZA 2WU9A 1PXTA 4E1LA 4UBUA 4YUFA 4N45A 1U0MA 5AB7A 5KP6A 4NA3A 2VBAA 3G0YA 4LS5A 5BY7A 4JAOA 4C70A 1YSLA 2IBWA 4NZSA 4WYRA 1M1TA 4B3HC 2VU0A 4LS8A 3WXYA 1HNKA 2WGEA 5KP7A 4UBTA 1E5MA 4KTMA 3TSYA 4Z19A 3GWAA 3ZBKA 2EBDA 1M4TA 4JAQA 2QO3A 2VZ9A 5LOTA 4NA2A 1HNDA 2D3MA 5AB5A 1OX0A 5LNQA 2QNZA 3S21A 3EUOA 2D3TC 4NA1A 5HWRA 4JAPA 3I8PA 5F38B 2IBYA 1TEEA 2GP6A 5LD8A 4WKYA 2IWYA 4YUCA 4WZUA 3ROWA 4Z37A 1DLVA 4W61A 4XSBA 2AQBA 1HNJA 2VB8A 1EBLA 1XPLA 1WDKC 1XPMA 1Z1EA 5BNMA 4WUMA 4QAVA 1BI5A 1D6IA 3WXZA 5F0VA 2VU1A 2WGDA 3EUTA 4JARA 4C73A 4R8EA 2AQ7A 4YXTA 1B3NA 4B3IC 5F38D 3GOAA 1KASA 2QO1A 1CGKA 2QO0A 3LMAA 4O9AA 4NHDA 2VB7A 4B7VA 2C7YA 1CHWA 3V4XA 4O9CA 2VB7C 1HNHA 5E5NA 4C6UA 3IL4A 1XETA 1M3KA 2BYYA 2GQDA 4C72A 2BUHA 2BUIA 3LEDA 2GFYA 4YXQA 4TKTA 4BIAA 5LP7A 3IL3A 3AWKA 2BZ3A 2D51A 4UBVA 4XS9A 4RYBA 1MZSA 5F38A 4EWPA 3GWEA 4YXVA 5F38C 4XOXA 3T5YB 2GFVA 5SXOA 3H76A 4XS7A 3WY0A 2UV8A 1FJ8A 1G5XA 2WGFA 3ALEA 1WL5A 1W0IA 3LM6A 3H77A 1TVZA 1U6EA 4B3JC 1QFLA 1TQYA 2EFTA 4YZOA 1TXTA 2QNXA 5BNSA 3WD7A 2WKUA 4X9OA 3ZBNA 1J3NA 5C1JA 4Z8DA 2X3EA 3AWJA 2AHBA 3H78A 3ZBLA 2P8UA 2IX4A 4JRMA 3HO9A 5TT4A 3A5RA 4JGAA 2AJ9A 1CGZA 3SS6A 4DFEA 1DLUA 4O99A 4B0NA 2WL4B 4KU2A 5HWOA 4JD3A 3T8EA 3E60A 4BI9A 2WGGA 3ZBGA 1BQ6A 2H84A 1QLVA 1HZPA 2QNYA 1HN9A 1CMLA 2WL5A 5BYVA 1OU6A 3LRFA 2P0UA 4XL2A 3T5YA 2WL5C 1F91A 5KP8A 3V4NA 1YSLB 3OV2A 5DWZC 1I8BA 2WL4D 4DD5A 1D6FA 3U0EA 4N44A 2WYAA 1JWXA 2F2SA 2F9AA 5BNRA 3HHDA 1EK4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3T6S B;  4XL3 A;  2WL6 A;  5CBQ A;  1TED A;  4C6V A;  2D52 A;  4U4E A;  1I86 A;  1ZOW A;  1NL7 A;  4X0O D;  3V7I A;  2ALM A;  1I88 A;  2HDB A;  2IIK A;  1MZJ A;  4JB6 A;  4C2J A;  4OQJ A;  3S20 A;  1U0W A;  3U0F A;  3MQD A;  4KTI A;  5AB6 A;  2WKT A;  1U6S A;  3E1H A;  1DM3 A;  4X9K A;  2WL4 C;  2WKT C;  4JV3 A;  4OPF A;  3IL6 A;  3OV3 A;  4QYR A;  1OXH A;  5BQS A;  1M3Z A;  2QX1 A;  2IBU A;  3IL9 A;  3G11 A;  4KC5 A;  4X0O A;  4UBW A;  3SVK A;  5AB4 A;  1XES A;  4YLT A;  3FK5 A;  4EWG A;  2IWZ A;  4ZRC A;  2IB9 A;  1XPK A;  3OYT A;  4EFI A;  1U0V A;  1WDM C;  3LEH A;  2GFW A;  3HO2 A;  3S3L A;  1XPK C;  2BZ4 A;  2WKV A;  1H4F A;  3A5S A;  1WL4 A;  2C7Z A;  3T6S A;  4JRH A;  5HWQ A;  1M1O A;  2WUA A;  1M4S A;  3S1Z A;  1AFW A;  2F82 A;  2HG4 A;  1EE0 A;  1ULQ A;  4WYS A;  2VTZ A;  2BYW A;  4ZDN A;  4LS6 A;  3WD8 A;  3EUQ A;  3S23 A;  4C6X A;  4F32 A;  4EGV A;  4XL4 A;  1X9E A;  2IB7 A;  2BYX A;  4JPF A;  3IL5 A;  3O04 A;  3KZU A;  4OPE A;  3A5Q A;  4YJY A;  4C71 A;  4DDO A;  2GYO A;  4KU5 A;  1D6H A;  4C6W A;  4V2P A;  1I89 A;  1UB7 A;  3OIT A;  5KP5 A;  1TQY B;  5BZ4 A;  1U0U A;  1Z1F A;  1WDL C;  2VZ8 A;  3VS8 A;  2VB9 A;  2FA0 A;  3HNZ A;  1FJ4 A;  2C9H A;  2BYZ A;  1M1M A;  4KU3 A;  2FA3 A;  4XSA A;  5HWP A;  3SQZ A;  3VS9 A;  2GFX A;  1DD8 A;  2VU2 A;  3IL7 A;  4C2K A;  2WL4 A;  5KP2 A;  4LS7 A;  4JAT A;  2RJT A;  2IB8 A;  4C6Z A;  2WU9 A;  1PXT A;  4E1L A;  4UBU A;  4YUF A;  4N45 A;  1U0M A;  5AB7 A;  5KP6 A;  4NA3 A;  2VBA A;  3G0Y A;  4LS5 A;  5BY7 A;  4JAO A;  4C70 A;  1YSL A;  2IBW A;  4NZS A;  4WYR A;  1M1T A;  4B3H C;  2VU0 A;  4LS8 A;  3WXY A;  1HNK A;  2WGE A;  5KP7 A;  4UBT A;  1E5M A;  4KTM A;  3TSY A;  4Z19 A;  3GWA A;  3ZBK A;  2EBD A;  1M4T A;  4JAQ A;  2QO3 A;  2VZ9 A;  5LOT A;  4NA2 A;  1HND A;  2D3M A;  5AB5 A;  1OX0 A;  5LNQ A;  2QNZ A;  3S21 A;  3EUO A;  2D3T C;  4NA1 A;  5HWR A;  4JAP A;  3I8P A;  5F38 B;  2IBY A;  1TEE A;  2GP6 A;  5LD8 A;  4WKY A;  2IWY A;  4YUC A;  4WZU A;  3ROW A;  4Z37 A;  1DLV A;  4W61 A;  4XSB A;  2AQB A;  1HNJ A;  2VB8 A;  1EBL A;  1XPL A;  1WDK C;  1XPM A;  1Z1E A;  5BNM A;  4WUM A;  4QAV A;  1BI5 A;  1D6I A;  3WXZ A;  5F0V A;  2VU1 A;  2WGD A;  3EUT A;  4JAR A;  4C73 A;  4R8E A;  2AQ7 A;  4YXT A;  1B3N A;  4B3I C;  5F38 D;  3GOA A;  1KAS A;  2QO1 A;  1CGK A;  2QO0 A;  4O9A A;  4NHD A;  2VB7 A;  4B7V A;  2C7Y A;  1CHW A;  3V4X A;  4O9C A;  2VB7 C;  1HNH A;  5E5N A;  4C6U A;  3IL4 A;  1XET A;  1M3K A;  2BYY A;  2GQD A;  4C72 A;  2BUH A;  2BUI A;  3LED A;  2GFY A;  4YXQ A;  4TKT A;  4BIA A;  5LP7 A;  3IL3 A;  3AWK A;  2BZ3 A;  2D51 A;  4UBV A;  4XS9 A;  4RYB A;  1MZS A;  5F38 A;  4EWP A;  3GWE A;  4YXV A;  5F38 C;  4XOX A;  3T5Y B;  2GFV A;  5SXO A;  3H76 A;  4XS7 A;  3WY0 A;  2UV8 A;  1FJ8 A;  1G5X A;  2WGF A;  3ALE A;  1WL5 A;  1W0I A;  3H77 A;  1TVZ A;  1U6E A;  4B3J C;  1QFL A;  1TQY A;  2EFT A;  4YZO A;  1TXT A;  2QNX A;  5BNS A;  3WD7 A;  2WKU A;  4X9O A;  3ZBN A;  1J3N A;  5C1J A;  4Z8D A;  2X3E A;  3AWJ A;  2AHB A;  3H78 A;  3ZBL A;  2P8U A;  2IX4 A;  4JRM A;  3HO9 A;  5TT4 A;  3A5R A;  4JGA A;  2AJ9 A;  1CGZ A;  3SS6 A;  4DFE A;  1DLU A;  4O99 A;  4B0N A;  2WL4 B;  4KU2 A;  5HWO A;  4JD3 A;  3T8E A;  3E60 A;  4BI9 A;  2WGG A;  3ZBG A;  1BQ6 A;  2H84 A;  1QLV A;  1HZP A;  2QNY A;  1HN9 A;  1CML A;  2WL5 A;  5BYV A;  1OU6 A;  3LRF A;  2P0U A;  4XL2 A;  3T5Y A;  2WL5 C;  1F91 A;  5KP8 A;  3V4N A;  1YSL B;  3OV2 A;  5DWZ C;  1I8B A;  2WL4 D;  4DD5 A;  1D6F A;  3U0E A;  4N44 A;  2WYA A;  1JWX A;  2F2S A;  2F9A A;  5BNR A;  3HHD A;  1EK4 A; 
#chains in the Genus database with same CATH topology
 3T6S B;  4XL3 A;  2WL6 A;  5CBQ A;  1TED A;  4C6V A;  2D52 A;  4U4E A;  1I86 A;  1ZOW A;  1NL7 A;  4X0O D;  3V7I A;  2ALM A;  1I88 A;  2HDB A;  2IIK A;  1MZJ A;  4JB6 A;  4C2J A;  4OQJ A;  3S20 A;  1U0W A;  3U0F A;  3MQD A;  4KTI A;  5AB6 A;  2WKT A;  1U6S A;  3E1H A;  1DM3 A;  4X9K A;  2WL4 C;  2WKT C;  4JV3 A;  4OPF A;  3IL6 A;  3OV3 A;  4QYR A;  1OXH A;  5BQS A;  1M3Z A;  2QX1 A;  2IBU A;  3IL9 A;  3G11 A;  4KC5 A;  4X0O A;  4UBW A;  3SVK A;  5AB4 A;  1XES A;  4YLT A;  3FK5 A;  4EWG A;  2IWZ A;  4ZRC A;  2IB9 A;  1XPK A;  3OYT A;  4EFI A;  1U0V A;  1WDM C;  3LEH A;  2GFW A;  3HO2 A;  3S3L A;  1XPK C;  2BZ4 A;  2WKV A;  1H4F A;  3A5S A;  1WL4 A;  2C7Z A;  3T6S A;  4JRH A;  5HWQ A;  1M1O A;  2WUA A;  1M4S A;  3S1Z A;  1AFW A;  2F82 A;  2HG4 A;  1EE0 A;  1ULQ A;  4WYS A;  2VTZ A;  2BYW A;  4ZDN A;  4LS6 A;  3WD8 A;  3EUQ A;  3S23 A;  4C6X A;  4F32 A;  4EGV A;  4XL4 A;  1X9E A;  2IB7 A;  2BYX A;  4JPF A;  3IL5 A;  3O04 A;  3KZU A;  4OPE A;  3A5Q A;  4YJY A;  4C71 A;  4DDO A;  2GYO A;  4KU5 A;  1D6H A;  4C6W A;  4V2P A;  1I89 A;  1UB7 A;  3OIT A;  5KP5 A;  1TQY B;  5BZ4 A;  1U0U A;  1Z1F A;  1WDL C;  2VZ8 A;  3VS8 A;  2VB9 A;  2FA0 A;  3HNZ A;  1FJ4 A;  2C9H A;  2BYZ A;  1M1M A;  4KU3 A;  2FA3 A;  4XSA A;  5HWP A;  3SQZ A;  3VS9 A;  2GFX A;  1DD8 A;  2VU2 A;  3IL7 A;  4C2K A;  2WL4 A;  5KP2 A;  4LS7 A;  4JAT A;  2RJT A;  2IB8 A;  4C6Z A;  2WU9 A;  1PXT A;  4E1L A;  4UBU A;  4YUF A;  4N45 A;  1U0M A;  5AB7 A;  5KP6 A;  4NA3 A;  2VBA A;  3G0Y A;  4LS5 A;  5BY7 A;  4JAO A;  4C70 A;  1YSL A;  2IBW A;  4NZS A;  4WYR A;  1M1T A;  4B3H C;  2VU0 A;  4LS8 A;  3WXY A;  1HNK A;  2WGE A;  5KP7 A;  4UBT A;  1E5M A;  4KTM A;  3TSY A;  4Z19 A;  3GWA A;  3ZBK A;  2EBD A;  1M4T A;  4JAQ A;  2QO3 A;  2VZ9 A;  5LOT A;  4NA2 A;  1HND A;  2D3M A;  5AB5 A;  1OX0 A;  5LNQ A;  2QNZ A;  3S21 A;  3EUO A;  2D3T C;  4NA1 A;  5HWR A;  4JAP A;  3I8P A;  5F38 B;  2IBY A;  1TEE A;  2GP6 A;  5LD8 A;  4WKY A;  2IWY A;  4YUC A;  4WZU A;  3ROW A;  4Z37 A;  1DLV A;  4W61 A;  4XSB A;  2AQB A;  1HNJ A;  2VB8 A;  1EBL A;  1XPL A;  1WDK C;  1XPM A;  1Z1E A;  5BNM A;  4WUM A;  4QAV A;  1BI5 A;  1D6I A;  3WXZ A;  5F0V A;  2VU1 A;  2WGD A;  3EUT A;  4JAR A;  4C73 A;  4R8E A;  2AQ7 A;  4YXT A;  1B3N A;  4B3I C;  5F38 D;  3GOA A;  1KAS A;  2QO1 A;  1CGK A;  2QO0 A;  3LMA A;  4O9A A;  4NHD A;  2VB7 A;  4B7V A;  2C7Y A;  1CHW A;  3V4X A;  4O9C A;  2VB7 C;  1HNH A;  5E5N A;  4C6U A;  3IL4 A;  1XET A;  1M3K A;  2BYY A;  2GQD A;  4C72 A;  2BUH A;  2BUI A;  3LED A;  2GFY A;  4YXQ A;  4TKT A;  4BIA A;  5LP7 A;  3IL3 A;  3AWK A;  2BZ3 A;  2D51 A;  4UBV A;  4XS9 A;  4RYB A;  1MZS A;  5F38 A;  4EWP A;  3GWE A;  4YXV A;  5F38 C;  4XOX A;  3T5Y B;  2GFV A;  5SXO A;  3H76 A;  4XS7 A;  3WY0 A;  2UV8 A;  1FJ8 A;  1G5X A;  2WGF A;  3ALE A;  1WL5 A;  1W0I A;  3LM6 A;  3H77 A;  1TVZ A;  1U6E A;  4B3J C;  1QFL A;  1TQY A;  2EFT A;  4YZO A;  1TXT A;  2QNX A;  5BNS A;  3WD7 A;  2WKU A;  4X9O A;  3ZBN A;  1J3N A;  5C1J A;  4Z8D A;  2X3E A;  3AWJ A;  2AHB A;  3H78 A;  3ZBL A;  2P8U A;  2IX4 A;  4JRM A;  3HO9 A;  5TT4 A;  3A5R A;  4JGA A;  2AJ9 A;  1CGZ A;  3SS6 A;  4DFE A;  1DLU A;  4O99 A;  4B0N A;  2WL4 B;  4KU2 A;  5HWO A;  4JD3 A;  3T8E A;  3E60 A;  4BI9 A;  2WGG A;  3ZBG A;  1BQ6 A;  2H84 A;  1QLV A;  1HZP A;  2QNY A;  1HN9 A;  1CML A;  2WL5 A;  5BYV A;  1OU6 A;  3LRF A;  2P0U A;  4XL2 A;  3T5Y A;  2WL5 C;  1F91 A;  5KP8 A;  3V4N A;  1YSL B;  3OV2 A;  5DWZ C;  1I8B A;  2WL4 D;  4DD5 A;  1D6F A;  3U0E A;  4N44 A;  2WYA A;  1JWX A;  2F2S A;  2F9A A;  5BNR A;  3HHD A;  1EK4 A; 
#chains in the Genus database with same CATH homology
 3T6S B;  4XL3 A;  2WL6 A;  5CBQ A;  1TED A;  4C6V A;  2D52 A;  4U4E A;  1I86 A;  1ZOW A;  1NL7 A;  4X0O D;  3V7I A;  2ALM A;  1I88 A;  2HDB A;  2IIK A;  1MZJ A;  4JB6 A;  4C2J A;  4OQJ A;  3S20 A;  1U0W A;  3U0F A;  3MQD A;  4KTI A;  5AB6 A;  2WKT A;  1U6S A;  3E1H A;  1DM3 A;  4X9K A;  2WL4 C;  2WKT C;  4JV3 A;  4OPF A;  3IL6 A;  3OV3 A;  4QYR A;  1OXH A;  5BQS A;  1M3Z A;  2QX1 A;  2IBU A;  3IL9 A;  3G11 A;  4KC5 A;  4X0O A;  4UBW A;  3SVK A;  5AB4 A;  1XES A;  4YLT A;  3FK5 A;  4EWG A;  2IWZ A;  4ZRC A;  2IB9 A;  1XPK A;  3OYT A;  4EFI A;  1U0V A;  1WDM C;  3LEH A;  2GFW A;  3HO2 A;  3S3L A;  1XPK C;  2BZ4 A;  2WKV A;  1H4F A;  3A5S A;  1WL4 A;  2C7Z A;  3T6S A;  4JRH A;  5HWQ A;  1M1O A;  2WUA A;  1M4S A;  3S1Z A;  1AFW A;  2F82 A;  2HG4 A;  1EE0 A;  1ULQ A;  4WYS A;  2VTZ A;  2BYW A;  4ZDN A;  4LS6 A;  3WD8 A;  3EUQ A;  3S23 A;  4C6X A;  4F32 A;  4EGV A;  4XL4 A;  1X9E A;  2IB7 A;  2BYX A;  4JPF A;  3IL5 A;  3O04 A;  3KZU A;  4OPE A;  3A5Q A;  4YJY A;  4C71 A;  4DDO A;  2GYO A;  4KU5 A;  1D6H A;  4C6W A;  4V2P A;  1I89 A;  1UB7 A;  3OIT A;  5KP5 A;  1TQY B;  5BZ4 A;  1U0U A;  1Z1F A;  1WDL C;  2VZ8 A;  3VS8 A;  2VB9 A;  2FA0 A;  3HNZ A;  1FJ4 A;  2C9H A;  2BYZ A;  1M1M A;  4KU3 A;  2FA3 A;  4XSA A;  5HWP A;  3SQZ A;  3VS9 A;  2GFX A;  1DD8 A;  2VU2 A;  3IL7 A;  4C2K A;  2WL4 A;  5KP2 A;  4LS7 A;  4JAT A;  2RJT A;  2IB8 A;  4C6Z A;  2WU9 A;  1PXT A;  4E1L A;  4UBU A;  4YUF A;  4N45 A;  1U0M A;  5AB7 A;  5KP6 A;  4NA3 A;  2VBA A;  3G0Y A;  4LS5 A;  5BY7 A;  4JAO A;  4C70 A;  1YSL A;  2IBW A;  4NZS A;  4WYR A;  1M1T A;  4B3H C;  2VU0 A;  4LS8 A;  3WXY A;  1HNK A;  2WGE A;  5KP7 A;  4UBT A;  1E5M A;  4KTM A;  3TSY A;  4Z19 A;  3GWA A;  3ZBK A;  2EBD A;  1M4T A;  4JAQ A;  2QO3 A;  2VZ9 A;  5LOT A;  4NA2 A;  1HND A;  2D3M A;  5AB5 A;  1OX0 A;  5LNQ A;  2QNZ A;  3S21 A;  3EUO A;  2D3T C;  4NA1 A;  5HWR A;  4JAP A;  3I8P A;  5F38 B;  2IBY A;  1TEE A;  2GP6 A;  5LD8 A;  4WKY A;  2IWY A;  4YUC A;  4WZU A;  3ROW A;  4Z37 A;  1DLV A;  4W61 A;  4XSB A;  2AQB A;  1HNJ A;  2VB8 A;  1EBL A;  1XPL A;  1WDK C;  1XPM A;  1Z1E A;  5BNM A;  4WUM A;  4QAV A;  1BI5 A;  1D6I A;  3WXZ A;  5F0V A;  2VU1 A;  2WGD A;  3EUT A;  4JAR A;  4C73 A;  4R8E A;  2AQ7 A;  4YXT A;  1B3N A;  4B3I C;  5F38 D;  3GOA A;  1KAS A;  2QO1 A;  1CGK A;  2QO0 A;  3LMA A;  4O9A A;  4NHD A;  2VB7 A;  4B7V A;  2C7Y A;  1CHW A;  3V4X A;  4O9C A;  2VB7 C;  1HNH A;  5E5N A;  4C6U A;  3IL4 A;  1XET A;  1M3K A;  2BYY A;  2GQD A;  4C72 A;  2BUH A;  2BUI A;  3LED A;  2GFY A;  4YXQ A;  4TKT A;  4BIA A;  5LP7 A;  3IL3 A;  3AWK A;  2BZ3 A;  2D51 A;  4UBV A;  4XS9 A;  4RYB A;  1MZS A;  5F38 A;  4EWP A;  3GWE A;  4YXV A;  5F38 C;  4XOX A;  3T5Y B;  2GFV A;  5SXO A;  3H76 A;  4XS7 A;  3WY0 A;  2UV8 A;  1FJ8 A;  1G5X A;  2WGF A;  3ALE A;  1WL5 A;  1W0I A;  3LM6 A;  3H77 A;  1TVZ A;  1U6E A;  4B3J C;  1QFL A;  1TQY A;  2EFT A;  4YZO A;  1TXT A;  2QNX A;  5BNS A;  3WD7 A;  2WKU A;  4X9O A;  3ZBN A;  1J3N A;  5C1J A;  4Z8D A;  2X3E A;  3AWJ A;  2AHB A;  3H78 A;  3ZBL A;  2P8U A;  2IX4 A;  4JRM A;  3HO9 A;  5TT4 A;  3A5R A;  4JGA A;  2AJ9 A;  1CGZ A;  3SS6 A;  4DFE A;  1DLU A;  4O99 A;  4B0N A;  2WL4 B;  4KU2 A;  5HWO A;  4JD3 A;  3T8E A;  3E60 A;  4BI9 A;  2WGG A;  3ZBG A;  1BQ6 A;  2H84 A;  1QLV A;  1HZP A;  2QNY A;  1HN9 A;  1CML A;  2WL5 A;  5BYV A;  1OU6 A;  3LRF A;  2P0U A;  4XL2 A;  3T5Y A;  2WL5 C;  1F91 A;  5KP8 A;  3V4N A;  1YSL B;  3OV2 A;  5DWZ C;  1I8B A;  2WL4 D;  4DD5 A;  1D6F A;  3U0E A;  4N44 A;  2WYA A;  1JWX A;  2F2S A;  2F9A A;  5BNR A;  3HHD A;  1EK4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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