2AZRA

Crystal structure of ptp1b with bicyclic thiophene inhibitor
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
297
structure length
297
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Tyrosine-protein phosphatase, non-receptor type 1
total genus 105
structure length 297
sequence length 297
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2005-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2azrA00
3QCEA 2I6PA 2B3OA 4RKKA 3OMHA 4GE6A 4D3PA 3S3EA 3O4UA 4Z6BA 1OHDA 2SHPA 1X24A 4H34A 3EMUA 1GWZA 3AWGA 1OEMX 4RDDA 4DGXA 2CNFA 3F81A 5KACA 2NT2A 1YZ4A 2B4PA 4TVVA 2P4DA 4NYHA 2I6IA 3D9CA 4NWGA 4RH5A 3EU0A 1WAXA 1J4XA 2H03A 4QBEA 1EEOA 1LYVA 1YTSA 2B4UA 4WU2A 3RGOA 3F41A 4GE5A 2GP0A 5K23A 3S3KA 4RI4A 2I6MA 3ZMQA 2PBNA 4MBBA 5BUGA 1T4JA 4KYRA 2VEWA 1KAVA 1YGRA 4R30A 3V0GA 1G7GA 5GTJA 4NWFA 5IBSA 1NO6A 3QCFA 4IKCA 3CWEA 5EHPA 4GFVA 2Q05A 2I3RA 4BPCA 2F6VA 1G1HA 1YPTA 4D3RA 3ZV2A 1U24A 1NNYA 4BJOA 1QXKA 5AWXA 2OUDA 3H2XA 3QKPA 2CFVA 2B4SA 4Y2EA 1ZCLA 2G6ZA 2QEPA 2PSZA 2VEYA 5MMZB 1FPZA 1G1GA 2HVLA 1NWLA 4QAHA 2A8BA 3BRHA 3F99A 3QCGA 3S3FA 2QBQA 4OHIA 1YFOA 4ERCA 2NLKA 2FH7A 1V3AA 2I4HA 2F46A 3A5KA 5KADA 3ZM3A 1R6HA 2CNGA 2CMAA 3I36A 2H4VA 2QBPA 1ZC0A 3M4UA 2RF6A 2H02A 3GXGA 3EZZA 4QUMA 3MMJA 3QCKA 2QDPA 2HY3A 2F6WA 3QCNA 3D42A 1Q6MA 2BZLA 5KAAA 2I4GA 4WTYA 1YGUA 1FPRA 2QBRA 3S4OA 1C88A 3O3LA 3A5JA 1G4WR 4KI9A 2G59A 2M3VA 1G7FA 4OHHA 4S0GA 1Q6NA 3EAXA 4WU3A 2ESBA 3ZM0A 3SR9A 1I9SA 2H4KA 1OEOX 1D5RA 2A3KA 1EENA 2CNHA 4NNDA 3SMEA 1PYNA 5K25A 1PTTA 2QDMA 3RZ2A 3AWEA 2CMCA 4QAPA 4QUNA 4OHLA 2Y96A 3QCLA 5K9VA 2GJTA 1U26A 2B49A 1I57A 2VEXA 3QCBA 1OEUA 1LARA 2CM3A 2PT0A 5KA7A 5BZZA 1FQ1A 1XM2A 3QCDA 1ZCKA 2B4OA 1AAXA 2CM2A 2WGPA 4R0TA 1XXVA 5J8RA 4D3QA 2QBSA 3O4SA 3EB1A 1JF7A 3AWFA 2FJMA 2HC2A 3QKQA 1PTYA 2NT7A 2AHSA 1YTNA 2PA5A 3QCIA 3D1QA 2VEUA 2I6JA 1Q6PA 3MOWA 1BZJA 2BIJA 2HC1A 2BGDA 3O4TA 1LQFA 3V0IA 3F9BA 3QCMA 2GWOA 2C46A 4GFUA 4ICZA 1P15A 1Q6TA 3I80A 2CJZA 4GWFA 3S3HA 2P6XA 2J16A 2Q47A 2H04A 3GXHA 3F9AA 1PH0A 1T49A 1T48A 4ZRTA 2BGEA 1GFYA 2E0TA 2QCTA 2HNQA 2OC3A 2MBCA 5K22A 1ONZA 4AZ1A 2PQ5A 3D1OA 2R0BA 4GRYA 4JBCA 1KAKA 5KABA 2F71A 1OETA 1NWEA 1PTVA 4PYHA 2VEVA 4JNBA 4R0SA 1WCHA 2QCJA 1C86A 4KYQA 5KA1A 2I42A 1RPMA 5KA9A 4HJPA 4JMKA 3LJ8A 3V0EA 3ZM2A 2OZ5A 1XRIA 3BLTA 2F6TA 5K9WA 2HB1A 2J17A 2CM8A 2CMBA 3D1HA 5IBMA 3S4EA 4JMJA 2F6FA 4GS0A 1I9TA 1JLNA 5LXQB 4OHEA 3V0JA 5KA2A 2NV5A 4HJQA 3ZM1A 2I75A 1G1FA 1C85A 1L8GA 2F6YA 4YAAA 2NTAA 3V0DA 2ZN7A 4DGPA 1NZ7A 2IMGA 3MOZA 2QDCA 1OEVA 4PVGA 3U96A 3BM8A 2NZ6A 1YWFA 4J51A 5HDEA 2DXPA 2H4GA 2I4EA 4GRZA 1Q6JA 1ZZWA 5KA4A 2PI7A 2FJNA 4RHGA 4I8NA 4RH9A 5EHRA 2I1YA 5BZXA 4H1OA 2I6OA 5K24A 1QZ0A 1M3GA 1A5YA 2JJDA 5M43A 4GE2A 5KA3A 2I3UA 1WRMA 1MKPA 5BX1A 2HXPA 2F70A 2HCMA 4ZI4A 3RGQA 3QCCA 2CM7A 3O5XA 3V0HA 2OOQA 2ZMMA 3B7OA 4YR8B 2YDUA 4Y14A 4ZN5A 3NMEA 1PTUA 1U25A 5KA0A 3ZMPA 3I7ZA 1OHCA 1ECVA 1YN9A 5KA8A 4QBWA 2B07A 1PXHA 4OHDA 1PA1A 3OLRA 1YTWA 1BZHA 1RXDA 1Q1MA 1ONYA 3D44A 3RO1A 2J16B 3CM3A 1Q6SA 2C7SA 1G4US 4NX8A 3QCHA 2BV5A 4B04A 2CNIA 1BZCA 1C83A 3PS5A 1XBOA 2F6ZA 2Y2FA 1L8KA 2CNEA 1OESA 3V0FA 1VHRA 1OHEA 1SUGA 2I5XA 5I6VA 1XXPA 1NL9A 4HRFA 3QCJA 4WOHA 3N0AA 1C87A 1PA9A 2AZRA 3BLUA 4RI5A 2HNPA 1C84A
chains in the Genus database with same CATH superfamily
3QCEA 2I6PA 2B3OA 4RKKA 3OMHA 4GE6A 4QDIA 1JBWA 4D3PA 3S3EA 3O4UA 4Z6BA 1OHDA 2SHPA 1X24A 4H34A 3EMUA 1GWZA 3AWGA 1OEMX 4RDDA 4DGXA 2CNFA 3F81A 5KACA 2NT2A 3ZL8A 1YZ4A 2B4PA 4TVVA 2P4DA 4NYHA 2I6IA 3D9CA 4NWGA 4RH5A 1UAGA 3EU0A 1WAXA 4BUCA 1J4XA 2H03A 4QBEA 1EEOA 1LYVA 1YTSA 2B4UA 4WU2A 3RGOA 2AM2A 3F41A 4GE5A 2GP0A 1E0DA 2UUPA 2WJPA 1GG4A 5K23A 3NRSA 3S3KA 4RI4A 2I6MA 3ZMQA 2PBNA 4MBBA 5BUGA 1T4JA 3HN7A 4KYRA 2VEWA 3N2AA 1KAVA 1YGRA 4R30A 3V0GA 1G7GA 3UAGA 5GTJA 4NWFA 5IBSA 1NO6A 3QCFA 4IKCA 3CWEA 5EHPA 4GFVA 2Q05A 2I3RA 4BPCA 2F6VA 1G1HA 1YPTA 4D3RA 3ZV2A 1U24A 1NNYA 2XJAA 4BJOA 1QXKA 2JFFA 5AWXA 4ZIYA 2OUDA 3H2XA 3QKPA 2CFVA 2B4SA 4Y2EA 1ZCLA 2G6ZA 2QEPA 4C12A 2PSZA 2VEYA 2VTEA 5MMZB 1FPZA 1G1GA 2HVLA 1NWLA 4QAHA 2A8BA 4HV4A 3BRHA 3F99A 2Y1OA 3QCGA 3S3FA 2QBQA 3ZM5A 4OHIA 1YFOA 4ERCA 2NLKA 2FH7A 1V3AA 2I4HA 2F46A 1GQQA 3A5KA 2Y68A 5KADA 1JBVA 3ZM3A 1R6HA 2CNGA 1EEHA 2CMAA 3I36A 2H4VA 2QBPA 1ZC0A 3M4UA 2RF6A 2H02A 3GXGA 3EZZA 4QUMA 3MMJA 3QCKA 2QDPA 2HY3A 2F6WA 3QCNA 3D42A 1Q6MA 2BZLA 5KAAA 2I4GA 4WTYA 1YGUA 4BUBA 1FPRA 2AM1A 2QBRA 3S4OA 1C88A 3O3LA 3A5JA 1G4WR 4KI9A 2G59A 2M3VA 1G7FA 4OHHA 4S0GA 1Q6NA 3EAXA 4WU3A 2ESBA 3ZM0A 3SR9A 1I9SA 5A5EA 2H4KA 1OEOX 1D5RA 2A3KA 1EENA 2CNHA 4NNDA 2X5OA 3SMEA 1PYNA 5K25A 1PTTA 2QDMA 3RZ2A 3AWEA 2CMCA 2Y67A 4QAPA 4QUNA 2JFHA 4OHLA 4QF5A 2Y96A 3QCLA 5K9VA 2GJTA 1U26A 2B49A 1I57A 2VEXA 3QCBA 1OEUA 1LARA 2CM3A 2PT0A 5KA7A 5BZZA 1FQ1A 1XM2A 3QCDA 1E8CA 2GC6A 1ZCKA 2B4OA 1AAXA 1FGSA 2CM2A 2WGPA 3MVNA 4R0TA 1XXVA 5J8RA 4D3QA 2QBSA 3O4SA 3EB1A 1JF7A 3AWFA 2FJMA 2HC2A 3QKQA 1PTYA 2NT7A 2AHSA 2VOSA 1YTNA 2PA5A 3QCIA 3D1QA 2VEUA 2I6JA 1Q6PA 1J6UA 3MOWA 1BZJA 2BIJA 3QCZA 2HC1A 2BGDA 3O4TA 1LQFA 4UAGA 3V0IA 3F9BA 3QCMA 2GWOA 2C46A 4GFUA 4ICZA 2JFGA 1P15A 1Q6TA 3I80A 2CJZA 4GWFA 3S3HA 2P6XA 2J16A 2Q47A 2H04A 3F9AA 3GXHA 1PH0A 1T49A 1T48A 4ZRTA 2BGEA 1GFYA 2E0TA 2QCTA 2HNQA 2OC3A 2MBCA 5K22A 2GC5A 1ONZA 4AZ1A 2PQ5A 3D1OA 2R0BA 4GRYA 4JBCA 1KAKA 2GCAA 5KABA 2F71A 1OETA 1NWEA 1PTVA 4PYHA 2VEVA 4JNBA 4R0SA 1WCHA 2QCJA 2VTDA 1C86A 4KYQA 5KA1A 2I42A 1RPMA 5KA9A 4HJPA 4JMKA 3LJ8A 4CVLA 3V0EA 3ZM2A 2OZ5A 1XRIA 3BLTA 2F6TA 5K9WA 2HB1A 2J17A 2CM8A 2CMBA 3D1HA 5IBMA 3S4EA 4JMJA 2F6FA 4GS0A 1I9TA 1JLNA 5A5FA 5LXQB 4OHEA 3V0JA 5KA2A 1O5ZA 2NV5A 4HJQA 3ZM1A 2I75A 1G1FA 1C85A 1L8GA 2F6YA 4YAAA 2Y66A 2NTAA 3V0DA 2ZN7A 4DGPA 1NZ7A 2IMGA 3MOZA 2QDCA 1OEVA 4PVGA 3U96A 3BM8A 2NZ6A 1YWFA 4J51A 5HDEA 2DXPA 2H4GA 2I4EA 4GRZA 1Q6JA 1ZZWA 2UAGA 5KA4A 2PI7A 2FJNA 4RHGA 4I8NA 2WTZA 4RH9A 5EHRA 2I1YA 1W7KA 5BZXA 4H1OA 2I6OA 5K24A 3ZM6A 1GQYA 1QZ0A 1M3GA 1A5YA 2JJDA 5M43A 4GE2A 5KA3A 2I3UA 1WRMA 1MKPA 5BX1A 2HXPA 2F70A 2HCMA 4ZI4A 3RGQA 3QCCA 2CM7A 3O5XA 3V0HA 2OOQA 2ZMMA 3B7OA 4YR8B 2YDUA 4Y14A 4ZN5A 3NMEA 1PTUA 1U25A 5KA0A 3ZMPA 3I7ZA 1OHCA 1ECVA 1YN9A 5KA8A 4QBWA 2B07A 1PXHA 4OHDA 1P31A 1PA1A 3OLRA 1YTWA 1BZHA 1RXDA 1Q1MA 1ONYA 3D44A 3RO1A 2J16B 3CM3A 1Q6SA 2C7SA 2GCBA 1G4US 2F00A 4NX8A 3QCHA 2UUOA 2BV5A 4B04A 2CNIA 1BZCA 1C83A 3PS5A 2XPCA 4CVMA 1XBOA 2F6ZA 2Y2FA 1L8KA 4C13A 2CNEA 3LK7A 1OESA 3V0FA 1P3DA 1W78A 1VHRA 1OHEA 1SUGA 2I5XA 5I6VA 1XXPA 1NL9A 4HRFA 3QCJA 2VORA 4WOHA 3N0AA 1C87A 1PA9A 2AZRA 3BLUA 4CVKA 4RI5A 2HNPA 1C84A 3PYZA
chains in the Genus database with same CATH topology
3QCEA 2I6PA 2B3OA 4RKKA 3OMHA 4GE6A 4D3PA 3S3EA 3O4UA 4Z6BA 1OHDA 2SHPA 1X24A 4H34A 3EMUA 1GWZA 3AWGA 1OEMX 4RDDA 4DGXA 2CNFA 3F81A 5KACA 2NT2A 1YZ4A 2B4PA 4TVVA 2P4DA 4NYHA 2I6IA 3D9CA 4NWGA 4RH5A 3EU0A 1WAXA 1J4XA 2H03A 4QBEA 1EEOA 1LYVA 1YTSA 2B4UA 4WU2A 3RGOA 3F41A 4GE5A 2GP0A 5K23A 3S3KA 4RI4A 2I6MA 3ZMQA 2PBNA 4MBBA 5BUGA 1T4JA 4KYRA 2VEWA 1KAVA 1YGRA 4R30A 3V0GA 1G7GA 5GTJA 4NWFA 5IBSA 1NO6A 3QCFA 4IKCA 3CWEA 5EHPA 4GFVA 2Q05A 2I3RA 4BPCA 2F6VA 1G1HA 1YPTA 4D3RA 3ZV2A 1U24A 1NNYA 4BJOA 1QXKA 5AWXA 2OUDA 3H2XA 3QKPA 2CFVA 2B4SA 4Y2EA 1ZCLA 2G6ZA 2QEPA 2PSZA 2VEYA 5MMZB 1FPZA 1G1GA 2HVLA 1NWLA 4QAHA 2A8BA 3BRHA 3F99A 3QCGA 3S3FA 2QBQA 4OHIA 1YFOA 4ERCA 2NLKA 2FH7A 1V3AA 2I4HA 2F46A 3A5KA 5KADA 3ZM3A 1R6HA 2CNGA 2CMAA 3I36A 2H4VA 2QBPA 1ZC0A 3M4UA 2RF6A 2H02A 3GXGA 3EZZA 4QUMA 3MMJA 3QCKA 2QDPA 2HY3A 2F6WA 3QCNA 3D42A 1Q6MA 2BZLA 5KAAA 2I4GA 4WTYA 1YGUA 1FPRA 2QBRA 3S4OA 1C88A 3O3LA 3A5JA 1G4WR 4KI9A 2G59A 2M3VA 1G7FA 4OHHA 4S0GA 1Q6NA 3EAXA 4WU3A 2ESBA 3ZM0A 3SR9A 1I9SA 2H4KA 1OEOX 1D5RA 2A3KA 1EENA 2CNHA 4NNDA 3SMEA 1PYNA 5K25A 1PTTA 2QDMA 3RZ2A 3AWEA 2CMCA 4QAPA 4QUNA 4OHLA 2Y96A 3QCLA 5K9VA 2GJTA 1U26A 2B49A 1I57A 2VEXA 3QCBA 1OEUA 1LARA 2CM3A 2PT0A 5KA7A 5BZZA 1FQ1A 1XM2A 3QCDA 1ZCKA 2B4OA 1AAXA 2CM2A 2WGPA 4R0TA 1XXVA 5J8RA 4D3QA 2QBSA 3O4SA 3EB1A 1JF7A 3AWFA 2FJMA 2HC2A 3QKQA 1PTYA 2NT7A 2AHSA 1YTNA 2PA5A 3QCIA 3D1QA 2VEUA 2I6JA 1Q6PA 3MOWA 1BZJA 2BIJA 2HC1A 2BGDA 3O4TA 1LQFA 3V0IA 3F9BA 3QCMA 2GWOA 2C46A 4GFUA 4ICZA 1P15A 1Q6TA 3I80A 2CJZA 4GWFA 3S3HA 2P6XA 2J16A 2Q47A 2H04A 3GXHA 3F9AA 1PH0A 1T49A 1T48A 4ZRTA 2BGEA 1GFYA 2E0TA 2QCTA 2HNQA 2OC3A 2MBCA 5K22A 1ONZA 4AZ1A 2PQ5A 3D1OA 2R0BA 4GRYA 4JBCA 1KAKA 5KABA 2F71A 1OETA 1NWEA 1PTVA 4PYHA 2VEVA 4JNBA 4R0SA 1WCHA 2QCJA 1C86A 4KYQA 5KA1A 2I42A 1RPMA 5KA9A 4HJPA 4JMKA 3LJ8A 3V0EA 3ZM2A 2OZ5A 1XRIA 3BLTA 2F6TA 5K9WA 2HB1A 2J17A 2CM8A 2CMBA 3D1HA 5IBMA 3S4EA 4JMJA 2F6FA 4GS0A 1I9TA 1JLNA 5LXQB 4OHEA 3V0JA 5KA2A 2NV5A 4HJQA 3ZM1A 2I75A 1G1FA 1C85A 1L8GA 2F6YA 4YAAA 2NTAA 3V0DA 2ZN7A 4DGPA 1NZ7A 2IMGA 3MOZA 2QDCA 1OEVA 4PVGA 3U96A 3BM8A 2NZ6A 1YWFA 4J51A 5HDEA 2DXPA 2H4GA 2I4EA 4GRZA 1Q6JA 1ZZWA 5KA4A 2PI7A 2FJNA 4RHGA 4I8NA 4RH9A 5EHRA 2I1YA 5BZXA 4H1OA 2I6OA 5K24A 1QZ0A 1M3GA 1A5YA 2JJDA 5M43A 4GE2A 5KA3A 2I3UA 1WRMA 1MKPA 5BX1A 2HXPA 2F70A 2HCMA 4ZI4A 3RGQA 3QCCA 2CM7A 3O5XA 3V0HA 2OOQA 2ZMMA 3B7OA 4YR8B 2YDUA 4Y14A 4ZN5A 3NMEA 1PTUA 1U25A 5KA0A 3ZMPA 3I7ZA 1OHCA 1ECVA 1YN9A 5KA8A 4QBWA 2B07A 1PXHA 4OHDA 1PA1A 3OLRA 1YTWA 1BZHA 1RXDA 1Q1MA 1ONYA 3D44A 3RO1A 2J16B 3CM3A 1Q6SA 2C7SA 1G4US 4NX8A 3QCHA 2BV5A 4B04A 2CNIA 1BZCA 1C83A 3PS5A 1XBOA 2F6ZA 2Y2FA 1L8KA 2CNEA 1OESA 3V0FA 1VHRA 1OHEA 1SUGA 2I5XA 5I6VA 1XXPA 1NL9A 4HRFA 3QCJA 4WOHA 3N0AA 1C87A 1PA9A 2AZRA 3BLUA 4RI5A 2HNPA 1C84A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QCE A;  2I6P A;  2B3O A;  4RKK A;  3OMH A;  4GE6 A;  4D3P A;  3S3E A;  3O4U A;  4Z6B A;  1OHD A;  2SHP A;  1X24 A;  4H34 A;  3EMU A;  1GWZ A;  3AWG A;  1OEM X;  4RDD A;  4DGX A;  2CNF A;  3F81 A;  5KAC A;  2NT2 A;  1YZ4 A;  2B4P A;  4TVV A;  2P4D A;  4NYH A;  2I6I A;  3D9C A;  4NWG A;  4RH5 A;  3EU0 A;  1WAX A;  1J4X A;  2H03 A;  4QBE A;  1EEO A;  1LYV A;  1YTS A;  2B4U A;  4WU2 A;  3RGO A;  3F41 A;  4GE5 A;  2GP0 A;  5K23 A;  3S3K A;  4RI4 A;  2I6M A;  3ZMQ A;  2PBN A;  4MBB A;  5BUG A;  1T4J A;  4KYR A;  2VEW A;  1KAV A;  1YGR A;  4R30 A;  3V0G A;  1G7G A;  5GTJ A;  4NWF A;  5IBS A;  1NO6 A;  3QCF A;  4IKC A;  3CWE A;  5EHP A;  4GFV A;  2Q05 A;  2I3R A;  4BPC A;  2F6V A;  1G1H A;  1YPT A;  4D3R A;  3ZV2 A;  1U24 A;  1NNY A;  4BJO A;  1QXK A;  5AWX A;  2OUD A;  3H2X A;  3QKP A;  2CFV A;  2B4S A;  4Y2E A;  1ZCL A;  2G6Z A;  2QEP A;  2PSZ A;  2VEY A;  5MMZ B;  1FPZ A;  1G1G A;  2HVL A;  1NWL A;  4QAH A;  2A8B A;  3BRH A;  3F99 A;  3QCG A;  3S3F A;  2QBQ A;  4OHI A;  1YFO A;  4ERC A;  2NLK A;  2FH7 A;  1V3A A;  2I4H A;  2F46 A;  3A5K A;  5KAD A;  3ZM3 A;  1R6H A;  2CNG A;  2CMA A;  3I36 A;  2H4V A;  2QBP A;  1ZC0 A;  3M4U A;  2RF6 A;  2H02 A;  3GXG A;  3EZZ A;  4QUM A;  3MMJ A;  3QCK A;  2QDP A;  2HY3 A;  2F6W A;  3QCN A;  3D42 A;  1Q6M A;  2BZL A;  5KAA A;  2I4G A;  4WTY A;  1YGU A;  1FPR A;  2QBR A;  3S4O A;  1C88 A;  3O3L A;  3A5J A;  1G4W R;  4KI9 A;  2G59 A;  2M3V A;  1G7F A;  4OHH A;  4S0G A;  1Q6N A;  3EAX A;  4WU3 A;  2ESB A;  3ZM0 A;  3SR9 A;  1I9S A;  2H4K A;  1OEO X;  1D5R A;  2A3K A;  1EEN A;  2CNH A;  4NND A;  3SME A;  1PYN A;  5K25 A;  1PTT A;  2QDM A;  3RZ2 A;  3AWE A;  2CMC A;  4QAP A;  4QUN A;  4OHL A;  2Y96 A;  3QCL A;  5K9V A;  2GJT A;  1U26 A;  2B49 A;  1I57 A;  2VEX A;  3QCB A;  1OEU A;  1LAR A;  2CM3 A;  2PT0 A;  5KA7 A;  5BZZ A;  1FQ1 A;  1XM2 A;  3QCD A;  1ZCK A;  2B4O A;  1AAX A;  2CM2 A;  2WGP A;  4R0T A;  1XXV A;  5J8R A;  4D3Q A;  2QBS A;  3O4S A;  3EB1 A;  1JF7 A;  3AWF A;  2FJM A;  2HC2 A;  3QKQ A;  1PTY A;  2NT7 A;  2AHS A;  1YTN A;  2PA5 A;  3QCI A;  3D1Q A;  2VEU A;  2I6J A;  1Q6P A;  3MOW A;  1BZJ A;  2BIJ A;  2HC1 A;  2BGD A;  3O4T A;  1LQF A;  3V0I A;  3F9B A;  3QCM A;  2GWO A;  2C46 A;  4GFU A;  4ICZ A;  1P15 A;  1Q6T A;  3I80 A;  2CJZ A;  4GWF A;  3S3H A;  2P6X A;  2J16 A;  2Q47 A;  2H04 A;  3GXH A;  3F9A A;  1PH0 A;  1T49 A;  1T48 A;  4ZRT A;  2BGE A;  1GFY A;  2E0T A;  2QCT A;  2HNQ A;  2OC3 A;  2MBC A;  5K22 A;  1ONZ A;  4AZ1 A;  2PQ5 A;  3D1O A;  2R0B A;  4GRY A;  4JBC A;  1KAK A;  5KAB A;  2F71 A;  1OET A;  1NWE A;  1PTV A;  4PYH A;  2VEV A;  4JNB A;  4R0S A;  1WCH A;  2QCJ A;  1C86 A;  4KYQ A;  5KA1 A;  2I42 A;  1RPM A;  5KA9 A;  4HJP A;  4JMK A;  3LJ8 A;  3V0E A;  3ZM2 A;  2OZ5 A;  1XRI A;  3BLT A;  2F6T A;  5K9W A;  2HB1 A;  2J17 A;  2CM8 A;  2CMB A;  3D1H A;  5IBM A;  3S4E A;  4JMJ A;  2F6F A;  4GS0 A;  1I9T A;  1JLN A;  5LXQ B;  4OHE A;  3V0J A;  5KA2 A;  2NV5 A;  4HJQ A;  3ZM1 A;  2I75 A;  1G1F A;  1C85 A;  1L8G A;  2F6Y A;  4YAA A;  2NTA A;  3V0D A;  2ZN7 A;  4DGP A;  1NZ7 A;  2IMG A;  3MOZ A;  2QDC A;  1OEV A;  4PVG A;  3U96 A;  3BM8 A;  2NZ6 A;  1YWF A;  4J51 A;  5HDE A;  2DXP A;  2H4G A;  2I4E A;  4GRZ A;  1Q6J A;  1ZZW A;  5KA4 A;  2PI7 A;  2FJN A;  4RHG A;  4I8N A;  4RH9 A;  5EHR A;  2I1Y A;  5BZX A;  4H1O A;  2I6O A;  5K24 A;  1QZ0 A;  1M3G A;  1A5Y A;  2JJD A;  5M43 A;  4GE2 A;  5KA3 A;  2I3U A;  1WRM A;  1MKP A;  5BX1 A;  2HXP A;  2F70 A;  2HCM A;  4ZI4 A;  3RGQ A;  3QCC A;  2CM7 A;  3O5X A;  3V0H A;  2OOQ A;  2ZMM A;  3B7O A;  4YR8 B;  2YDU A;  4Y14 A;  4ZN5 A;  3NME A;  1PTU A;  1U25 A;  5KA0 A;  3ZMP A;  3I7Z A;  1OHC A;  1ECV A;  1YN9 A;  5KA8 A;  4QBW A;  2B07 A;  1PXH A;  4OHD A;  1PA1 A;  3OLR A;  1YTW A;  1BZH A;  1RXD A;  1Q1M A;  1ONY A;  3D44 A;  3RO1 A;  2J16 B;  3CM3 A;  1Q6S A;  2C7S A;  1G4U S;  4NX8 A;  3QCH A;  2BV5 A;  4B04 A;  2CNI A;  1BZC A;  1C83 A;  3PS5 A;  1XBO A;  2F6Z A;  2Y2F A;  1L8K A;  2CNE A;  1OES A;  3V0F A;  1VHR A;  1OHE A;  1SUG A;  2I5X A;  5I6V A;  1XXP A;  1NL9 A;  4HRF A;  3QCJ A;  4WOH A;  3N0A A;  1C87 A;  1PA9 A;  2AZR A;  3BLU A;  4RI5 A;  2HNP A;  1C84 A; 
#chains in the Genus database with same CATH topology
 3QCE A;  2I6P A;  2B3O A;  4RKK A;  3OMH A;  4GE6 A;  4QDI A;  1JBW A;  4D3P A;  3S3E A;  3O4U A;  4Z6B A;  1OHD A;  2SHP A;  1X24 A;  4H34 A;  3EMU A;  1GWZ A;  3AWG A;  1OEM X;  4RDD A;  4DGX A;  2CNF A;  3F81 A;  5KAC A;  2NT2 A;  3ZL8 A;  1YZ4 A;  2B4P A;  4TVV A;  2P4D A;  4NYH A;  2I6I A;  3D9C A;  4NWG A;  4RH5 A;  1UAG A;  3EU0 A;  1WAX A;  4BUC A;  1J4X A;  2H03 A;  4QBE A;  1EEO A;  1LYV A;  1YTS A;  2B4U A;  4WU2 A;  3RGO A;  2AM2 A;  3F41 A;  4GE5 A;  2GP0 A;  1E0D A;  2UUP A;  2WJP A;  1GG4 A;  5K23 A;  3NRS A;  3S3K A;  4RI4 A;  2I6M A;  3ZMQ A;  2PBN A;  4MBB A;  5BUG A;  1T4J A;  3HN7 A;  4KYR A;  2VEW A;  3N2A A;  1KAV A;  1YGR A;  4R30 A;  3V0G A;  1G7G A;  3UAG A;  5GTJ A;  4NWF A;  5IBS A;  1NO6 A;  3QCF A;  4IKC A;  3CWE A;  5EHP A;  4GFV A;  2Q05 A;  2I3R A;  4BPC A;  2F6V A;  1G1H A;  1YPT A;  4D3R A;  3ZV2 A;  1U24 A;  1NNY A;  2XJA A;  4BJO A;  1QXK A;  2JFF A;  5AWX A;  4ZIY A;  2OUD A;  3H2X A;  3QKP A;  2CFV A;  2B4S A;  4Y2E A;  1ZCL A;  2G6Z A;  2QEP A;  4C12 A;  2PSZ A;  2VEY A;  2VTE A;  5MMZ B;  1FPZ A;  1G1G A;  2HVL A;  1NWL A;  4QAH A;  2A8B A;  4HV4 A;  3BRH A;  3F99 A;  2Y1O A;  3QCG A;  3S3F A;  2QBQ A;  3ZM5 A;  4OHI A;  1YFO A;  4ERC A;  2NLK A;  2FH7 A;  1V3A A;  2I4H A;  2F46 A;  1GQQ A;  3A5K A;  2Y68 A;  5KAD A;  1JBV A;  3ZM3 A;  1R6H A;  2CNG A;  1EEH A;  2CMA A;  3I36 A;  2H4V A;  2QBP A;  1ZC0 A;  3M4U A;  2RF6 A;  2H02 A;  3GXG A;  3EZZ A;  4QUM A;  3MMJ A;  3QCK A;  2QDP A;  2HY3 A;  2F6W A;  3QCN A;  3D42 A;  1Q6M A;  2BZL A;  5KAA A;  2I4G A;  4WTY A;  1YGU A;  4BUB A;  1FPR A;  2AM1 A;  2QBR A;  3S4O A;  1C88 A;  3O3L A;  3A5J A;  1G4W R;  4KI9 A;  2G59 A;  2M3V A;  1G7F A;  4OHH A;  4S0G A;  1Q6N A;  3EAX A;  4WU3 A;  2ESB A;  3ZM0 A;  3SR9 A;  1I9S A;  5A5E A;  2H4K A;  1OEO X;  1D5R A;  2A3K A;  1EEN A;  2CNH A;  4NND A;  2X5O A;  3SME A;  1PYN A;  5K25 A;  1PTT A;  2QDM A;  3RZ2 A;  3AWE A;  2CMC A;  2Y67 A;  4QAP A;  4QUN A;  2JFH A;  4OHL A;  4QF5 A;  2Y96 A;  3QCL A;  5K9V A;  2GJT A;  1U26 A;  2B49 A;  1I57 A;  2VEX A;  3QCB A;  1OEU A;  1LAR A;  2CM3 A;  2PT0 A;  5KA7 A;  5BZZ A;  1FQ1 A;  1XM2 A;  3QCD A;  1E8C A;  2GC6 A;  1ZCK A;  2B4O A;  1AAX A;  1FGS A;  2CM2 A;  2WGP A;  3MVN A;  4R0T A;  1XXV A;  5J8R A;  4D3Q A;  2QBS A;  3O4S A;  3EB1 A;  1JF7 A;  3AWF A;  2FJM A;  2HC2 A;  3QKQ A;  1PTY A;  2NT7 A;  2AHS A;  2VOS A;  1YTN A;  2PA5 A;  3QCI A;  3D1Q A;  2VEU A;  2I6J A;  1Q6P A;  1J6U A;  3MOW A;  1BZJ A;  2BIJ A;  3QCZ A;  2HC1 A;  2BGD A;  3O4T A;  1LQF A;  4UAG A;  3V0I A;  3F9B A;  3QCM A;  2GWO A;  2C46 A;  4GFU A;  4ICZ A;  2JFG A;  1P15 A;  1Q6T A;  3I80 A;  2CJZ A;  4GWF A;  3S3H A;  2P6X A;  2J16 A;  2Q47 A;  2H04 A;  3F9A A;  3GXH A;  1PH0 A;  1T49 A;  1T48 A;  4ZRT A;  2BGE A;  1GFY A;  2E0T A;  2QCT A;  2HNQ A;  2OC3 A;  2MBC A;  5K22 A;  2GC5 A;  1ONZ A;  4AZ1 A;  2PQ5 A;  3D1O A;  2R0B A;  4GRY A;  4JBC A;  1KAK A;  2GCA A;  5KAB A;  2F71 A;  1OET A;  1NWE A;  1PTV A;  4PYH A;  2VEV A;  4JNB A;  4R0S A;  1WCH A;  2QCJ A;  2VTD A;  1C86 A;  4KYQ A;  5KA1 A;  2I42 A;  1RPM A;  5KA9 A;  4HJP A;  4JMK A;  3LJ8 A;  4CVL A;  3V0E A;  3ZM2 A;  2OZ5 A;  1XRI A;  3BLT A;  2F6T A;  5K9W A;  2HB1 A;  2J17 A;  2CM8 A;  2CMB A;  3D1H A;  5IBM A;  3S4E A;  4JMJ A;  2F6F A;  4GS0 A;  1I9T A;  1JLN A;  5A5F A;  5LXQ B;  4OHE A;  3V0J A;  5KA2 A;  1O5Z A;  2NV5 A;  4HJQ A;  3ZM1 A;  2I75 A;  1G1F A;  1C85 A;  1L8G A;  2F6Y A;  4YAA A;  2Y66 A;  2NTA A;  3V0D A;  2ZN7 A;  4DGP A;  1NZ7 A;  2IMG A;  3MOZ A;  2QDC A;  1OEV A;  4PVG A;  3U96 A;  3BM8 A;  2NZ6 A;  1YWF A;  4J51 A;  5HDE A;  2DXP A;  2H4G A;  2I4E A;  4GRZ A;  1Q6J A;  1ZZW A;  2UAG A;  5KA4 A;  2PI7 A;  2FJN A;  4RHG A;  4I8N A;  2WTZ A;  4RH9 A;  5EHR A;  2I1Y A;  1W7K A;  5BZX A;  4H1O A;  2I6O A;  5K24 A;  3ZM6 A;  1GQY A;  1QZ0 A;  1M3G A;  1A5Y A;  2JJD A;  5M43 A;  4GE2 A;  5KA3 A;  2I3U A;  1WRM A;  1MKP A;  5BX1 A;  2HXP A;  2F70 A;  2HCM A;  4ZI4 A;  3RGQ A;  3QCC A;  2CM7 A;  3O5X A;  3V0H A;  2OOQ A;  2ZMM A;  3B7O A;  4YR8 B;  2YDU A;  4Y14 A;  4ZN5 A;  3NME A;  1PTU A;  1U25 A;  5KA0 A;  3ZMP A;  3I7Z A;  1OHC A;  1ECV A;  1YN9 A;  5KA8 A;  4QBW A;  2B07 A;  1PXH A;  4OHD A;  1P31 A;  1PA1 A;  3OLR A;  1YTW A;  1BZH A;  1RXD A;  1Q1M A;  1ONY A;  3D44 A;  3RO1 A;  2J16 B;  3CM3 A;  1Q6S A;  2C7S A;  2GCB A;  1G4U S;  2F00 A;  4NX8 A;  3QCH A;  2UUO A;  2BV5 A;  4B04 A;  2CNI A;  1BZC A;  1C83 A;  3PS5 A;  2XPC A;  4CVM A;  1XBO A;  2F6Z A;  2Y2F A;  1L8K A;  4C13 A;  2CNE A;  3LK7 A;  1OES A;  3V0F A;  1P3D A;  1W78 A;  1VHR A;  1OHE A;  1SUG A;  2I5X A;  5I6V A;  1XXP A;  1NL9 A;  4HRF A;  3QCJ A;  2VOR A;  4WOH A;  3N0A A;  1C87 A;  1PA9 A;  2AZR A;  3BLU A;  4CVK A;  4RI5 A;  2HNP A;  1C84 A;  3PYZ A; 
#chains in the Genus database with same CATH homology
 3QCE A;  2I6P A;  2B3O A;  4RKK A;  3OMH A;  4GE6 A;  4D3P A;  3S3E A;  3O4U A;  4Z6B A;  1OHD A;  2SHP A;  1X24 A;  4H34 A;  3EMU A;  1GWZ A;  3AWG A;  1OEM X;  4RDD A;  4DGX A;  2CNF A;  3F81 A;  5KAC A;  2NT2 A;  1YZ4 A;  2B4P A;  4TVV A;  2P4D A;  4NYH A;  2I6I A;  3D9C A;  4NWG A;  4RH5 A;  3EU0 A;  1WAX A;  1J4X A;  2H03 A;  4QBE A;  1EEO A;  1LYV A;  1YTS A;  2B4U A;  4WU2 A;  3RGO A;  3F41 A;  4GE5 A;  2GP0 A;  5K23 A;  3S3K A;  4RI4 A;  2I6M A;  3ZMQ A;  2PBN A;  4MBB A;  5BUG A;  1T4J A;  4KYR A;  2VEW A;  1KAV A;  1YGR A;  4R30 A;  3V0G A;  1G7G A;  5GTJ A;  4NWF A;  5IBS A;  1NO6 A;  3QCF A;  4IKC A;  3CWE A;  5EHP A;  4GFV A;  2Q05 A;  2I3R A;  4BPC A;  2F6V A;  1G1H A;  1YPT A;  4D3R A;  3ZV2 A;  1U24 A;  1NNY A;  4BJO A;  1QXK A;  5AWX A;  2OUD A;  3H2X A;  3QKP A;  2CFV A;  2B4S A;  4Y2E A;  1ZCL A;  2G6Z A;  2QEP A;  2PSZ A;  2VEY A;  5MMZ B;  1FPZ A;  1G1G A;  2HVL A;  1NWL A;  4QAH A;  2A8B A;  3BRH A;  3F99 A;  3QCG A;  3S3F A;  2QBQ A;  4OHI A;  1YFO A;  4ERC A;  2NLK A;  2FH7 A;  1V3A A;  2I4H A;  2F46 A;  3A5K A;  5KAD A;  3ZM3 A;  1R6H A;  2CNG A;  2CMA A;  3I36 A;  2H4V A;  2QBP A;  1ZC0 A;  3M4U A;  2RF6 A;  2H02 A;  3GXG A;  3EZZ A;  4QUM A;  3MMJ A;  3QCK A;  2QDP A;  2HY3 A;  2F6W A;  3QCN A;  3D42 A;  1Q6M A;  2BZL A;  5KAA A;  2I4G A;  4WTY A;  1YGU A;  1FPR A;  2QBR A;  3S4O A;  1C88 A;  3O3L A;  3A5J A;  1G4W R;  4KI9 A;  2G59 A;  2M3V A;  1G7F A;  4OHH A;  4S0G A;  1Q6N A;  3EAX A;  4WU3 A;  2ESB A;  3ZM0 A;  3SR9 A;  1I9S A;  2H4K A;  1OEO X;  1D5R A;  2A3K A;  1EEN A;  2CNH A;  4NND A;  3SME A;  1PYN A;  5K25 A;  1PTT A;  2QDM A;  3RZ2 A;  3AWE A;  2CMC A;  4QAP A;  4QUN A;  4OHL A;  2Y96 A;  3QCL A;  5K9V A;  2GJT A;  1U26 A;  2B49 A;  1I57 A;  2VEX A;  3QCB A;  1OEU A;  1LAR A;  2CM3 A;  2PT0 A;  5KA7 A;  5BZZ A;  1FQ1 A;  1XM2 A;  3QCD A;  1ZCK A;  2B4O A;  1AAX A;  2CM2 A;  2WGP A;  4R0T A;  1XXV A;  5J8R A;  4D3Q A;  2QBS A;  3O4S A;  3EB1 A;  1JF7 A;  3AWF A;  2FJM A;  2HC2 A;  3QKQ A;  1PTY A;  2NT7 A;  2AHS A;  1YTN A;  2PA5 A;  3QCI A;  3D1Q A;  2VEU A;  2I6J A;  1Q6P A;  3MOW A;  1BZJ A;  2BIJ A;  2HC1 A;  2BGD A;  3O4T A;  1LQF A;  3V0I A;  3F9B A;  3QCM A;  2GWO A;  2C46 A;  4GFU A;  4ICZ A;  1P15 A;  1Q6T A;  3I80 A;  2CJZ A;  4GWF A;  3S3H A;  2P6X A;  2J16 A;  2Q47 A;  2H04 A;  3GXH A;  3F9A A;  1PH0 A;  1T49 A;  1T48 A;  4ZRT A;  2BGE A;  1GFY A;  2E0T A;  2QCT A;  2HNQ A;  2OC3 A;  2MBC A;  5K22 A;  1ONZ A;  4AZ1 A;  2PQ5 A;  3D1O A;  2R0B A;  4GRY A;  4JBC A;  1KAK A;  5KAB A;  2F71 A;  1OET A;  1NWE A;  1PTV A;  4PYH A;  2VEV A;  4JNB A;  4R0S A;  1WCH A;  2QCJ A;  1C86 A;  4KYQ A;  5KA1 A;  2I42 A;  1RPM A;  5KA9 A;  4HJP A;  4JMK A;  3LJ8 A;  3V0E A;  3ZM2 A;  2OZ5 A;  1XRI A;  3BLT A;  2F6T A;  5K9W A;  2HB1 A;  2J17 A;  2CM8 A;  2CMB A;  3D1H A;  5IBM A;  3S4E A;  4JMJ A;  2F6F A;  4GS0 A;  1I9T A;  1JLN A;  5LXQ B;  4OHE A;  3V0J A;  5KA2 A;  2NV5 A;  4HJQ A;  3ZM1 A;  2I75 A;  1G1F A;  1C85 A;  1L8G A;  2F6Y A;  4YAA A;  2NTA A;  3V0D A;  2ZN7 A;  4DGP A;  1NZ7 A;  2IMG A;  3MOZ A;  2QDC A;  1OEV A;  4PVG A;  3U96 A;  3BM8 A;  2NZ6 A;  1YWF A;  4J51 A;  5HDE A;  2DXP A;  2H4G A;  2I4E A;  4GRZ A;  1Q6J A;  1ZZW A;  5KA4 A;  2PI7 A;  2FJN A;  4RHG A;  4I8N A;  4RH9 A;  5EHR A;  2I1Y A;  5BZX A;  4H1O A;  2I6O A;  5K24 A;  1QZ0 A;  1M3G A;  1A5Y A;  2JJD A;  5M43 A;  4GE2 A;  5KA3 A;  2I3U A;  1WRM A;  1MKP A;  5BX1 A;  2HXP A;  2F70 A;  2HCM A;  4ZI4 A;  3RGQ A;  3QCC A;  2CM7 A;  3O5X A;  3V0H A;  2OOQ A;  2ZMM A;  3B7O A;  4YR8 B;  2YDU A;  4Y14 A;  4ZN5 A;  3NME A;  1PTU A;  1U25 A;  5KA0 A;  3ZMP A;  3I7Z A;  1OHC A;  1ECV A;  1YN9 A;  5KA8 A;  4QBW A;  2B07 A;  1PXH A;  4OHD A;  1PA1 A;  3OLR A;  1YTW A;  1BZH A;  1RXD A;  1Q1M A;  1ONY A;  3D44 A;  3RO1 A;  2J16 B;  3CM3 A;  1Q6S A;  2C7S A;  1G4U S;  4NX8 A;  3QCH A;  2BV5 A;  4B04 A;  2CNI A;  1BZC A;  1C83 A;  3PS5 A;  1XBO A;  2F6Z A;  2Y2F A;  1L8K A;  2CNE A;  1OES A;  3V0F A;  1VHR A;  1OHE A;  1SUG A;  2I5X A;  5I6V A;  1XXP A;  1NL9 A;  4HRF A;  3QCJ A;  4WOH A;  3N0A A;  1C87 A;  1PA9 A;  2AZR A;  3BLU A;  4RI5 A;  2HNP A;  1C84 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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