2B3KA

Crystal structure of human methionine aminopeptidase type i in the holo form
Total Genus 98
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,).
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 98
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2b3kA00
2P99A 2P98A 1WN1A 2V3ZA 2B3HA 2GG5A 2GG3A 2Q95A 1QXWA 1XGSA 2BB7A 2EVCA 3MX6A 4U76A 5E5BA 1W2MA 2IW2A 3IG4A 3PKCA 4HXXA 1C23A 3CB6A 2BHCA 1WY2A 4A6VA 4U6EA 4U6CA 2P9AA 2GGCA 2GTXA 3TAVA 2GA2A 2GZ5A 2GU5A 2OAZA 3BIPA 2BWTA 2BH3A 4FLJA 4PNCA 4ZWOA 5CIKA 2EVMA 1YJ3A 2BWWA 1XGNA 2BWVA 4IDYA 4ZWPA 4PV4A 3CTZA 2GGBA 1KQ9A 3PKEA 5D6FA 4FLIA 4RZYA 1QZYA 4U6ZA 2OKNA 4R60A 4EGEA 5CNXA 2V3XA 2GG2A 2Q92A 4IKUA 1WKMA 4S01A 1M35A 1A16A 1MATA 4JUQA 4U75A 1W7VA 2NQ6A 3S6BA 3PKDA 2GU6A 2GG9A 4U1BA 5FCFA 4FLKA 2BWUA 2Q93A 1N51A 3MATA 1B6AA 1XGOA 1YW8A 3CB5A 3TB5A 1YW9A 1WLRA 1KQ0A 4FUKA 2GU7A 4IPAA 2EA4A 2MATA 2NQ7A 4IU6A 4IF7A 4FLLA 1BN5A 2GG8A 4ZWUA 4OOKA 1WBQA 2Q8KA 5JI6A 2DFIA 1KP0A 3BITA 2G6PA 4S00A 1YVMA 4IECA 3IU9A 4U69A 1C24A 4S2RP 2V6CA 2B3KA 1B59A 3PKAA 5CDVA 4IKSA 3PKBA 4QR8A 2BWXA 4IKRA 1WL9A 1QXYA 4FO8A 1O0XA 4A6WA 1JAWA 1XGMA 2Q96A 5CDLA 5CE6A 5CDEA 3FMRA 4U73A 4FKCA 4KM3A 3D27A 4S2TP 1YW7A 1R5HA 1C22A 3RORA 5CLSA 2BHDA 2ZSGA 5D6EA 2Q94A 2BHBA 2GG0A 1R58A 2ADUA 1CHMA 3MR1A 3Q6DA 2BN7A 4U6WA 4B28A 1QXZA 5FCHA 1XNZA 2BHAA 3RVAA 2GU4A 4U71A 2EA2A 1WL6A 1R5GA 3IU7A 4ZNGA 2EVOA 1BOAA 4RGZ1 2B3LA 4RZZA 4Z7MA 4U70A 3BIQA 3FM3A 2V3YA 3IU8A 4MATA 1PV9A 1Y1NA 4U6JA 3FMQA 3L24A 2GG7A 3L7GA 4FO7A 5JFRA 5JHUA 2BWYA 1C27A 2BWSA 4IKTA 1C21A 2HOWA
chains in the Genus database with same CATH superfamily
2P99A 2P98A 1WN1A 2V3ZA 2B3HA 2GG5A 2GG3A 2Q95A 1QXWA 1XGSA 2BB7A 2EVCA 3MX6A 4U76A 5E5BA 1W2MA 2IW2A 3IG4A 3PKCA 4HXXA 1C23A 3CB6A 2BHCA 1WY2A 4A6VA 4U6EA 4U6CA 2P9AA 2GGCA 2GTXA 3TAVA 2GA2A 2GZ5A 2GU5A 2OAZA 3BIPA 2BWTA 2BH3A 4FLJA 4PNCA 4ZWOA 5CIKA 2EVMA 1YJ3A 2BWWA 1XGNA 2BWVA 4IDYA 4ZWPA 4PV4A 3CTZA 2GGBA 1KQ9A 3PKEA 5D6FA 4FLIA 4RZYA 1QZYA 4U6ZA 2OKNA 4R60A 4EGEA 5CNXA 2V3XA 2GG2A 2Q92A 4IKUA 1WKMA 4S01A 1M35A 1A16A 1MATA 4JUQA 4U75A 1W7VA 2NQ6A 3S6BA 3PKDA 2GU6A 2GG9A 4U1BA 5FCFA 4FLKA 2BWUA 2Q93A 1N51A 3MATA 1B6AA 1XGOA 1YW8A 3CB5A 3TB5A 1YW9A 1WLRA 1KQ0A 4FUKA 2GU7A 4IPAA 2EA4A 2MATA 2NQ7A 4IU6A 4IF7A 4FLLA 1BN5A 2GG8A 4ZWUA 4OOKA 1WBQA 2Q8KA 5JI6A 2DFIA 1KP0A 3BITA 2G6PA 4S00A 1YVMA 4IECA 3IU9A 4U69A 1C24A 4S2RP 2V6CA 2B3KA 1B59A 3PKAA 5CDVA 4IKSA 3PKBA 4QR8A 2BWXA 4IKRA 1WL9A 1QXYA 4FO8A 1O0XA 4A6WA 1JAWA 1XGMA 2Q96A 5CDLA 5CE6A 5CDEA 3FMRA 4U73A 4FKCA 4KM3A 3D27A 4S2TP 1YW7A 1R5HA 1C22A 3RORA 5CLSA 2BHDA 2ZSGA 5D6EA 2Q94A 2BHBA 2GG0A 1R58A 2ADUA 1CHMA 3MR1A 3Q6DA 2BN7A 4U6WA 4B28A 1QXZA 5FCHA 1XNZA 2BHAA 3RVAA 2GU4A 4U71A 2EA2A 1WL6A 1R5GA 3IU7A 4ZNGA 2EVOA 1BOAA 4RGZ1 2B3LA 4RZZA 4Z7MA 4U70A 3BIQA 3FM3A 2V3YA 3IU8A 4MATA 1PV9A 1Y1NA 4U6JA 3FMQA 3L24A 2GG7A 3L7GA 4FO7A 5JFRA 5JHUA 2BWYA 1C27A 2BWSA 4IKTA 1C21A 2HOWA
chains in the Genus database with same CATH topology
2P99A 2P98A 1WN1A 2V3ZA 2B3HA 2GG5A 2GG3A 2Q95A 1QXWA 1XGSA 2BB7A 2EVCA 3MX6A 4U76A 5E5BA 1W2MA 2IW2A 3IG4A 3PKCA 4HXXA 1C23A 3CB6A 2BHCA 1WY2A 4A6VA 4U6EA 4U6CA 2P9AA 2GGCA 2GTXA 3TAVA 2GA2A 2GZ5A 2GU5A 2OAZA 3BIPA 2BWTA 2BH3A 4FLJA 4PNCA 4ZWOA 5CIKA 2EVMA 1YJ3A 2BWWA 1XGNA 2BWVA 4IDYA 4ZWPA 4PV4A 3CTZA 2GGBA 1KQ9A 3PKEA 5D6FA 4FLIA 4RZYA 1QZYA 4U6ZA 2OKNA 4R60A 4EGEA 5CNXA 2V3XA 2GG2A 2Q92A 4IKUA 1WKMA 4S01A 1M35A 1A16A 1MATA 4JUQA 4U75A 1W7VA 2NQ6A 3S6BA 3PKDA 2GU6A 2GG9A 4U1BA 5FCFA 4FLKA 2BWUA 2Q93A 1N51A 3MATA 1B6AA 1XGOA 1YW8A 3CB5A 3TB5A 1YW9A 1WLRA 1KQ0A 4FUKA 2GU7A 4IPAA 2EA4A 2MATA 2NQ7A 4IU6A 4IF7A 4FLLA 1BN5A 2GG8A 4ZWUA 4OOKA 1WBQA 2Q8KA 5JI6A 2DFIA 1KP0A 3BITA 2G6PA 4S00A 1YVMA 4IECA 3IU9A 4U69A 1C24A 4S2RP 2V6CA 2B3KA 1B59A 3PKAA 5CDVA 4IKSA 3PKBA 4QR8A 2BWXA 4IKRA 1WL9A 1QXYA 4FO8A 1O0XA 4A6WA 1JAWA 1XGMA 2Q96A 5CDLA 5CE6A 5CDEA 3FMRA 4U73A 4FKCA 4KM3A 3D27A 4S2TP 1YW7A 1R5HA 1C22A 3RORA 5CLSA 2BHDA 2ZSGA 5D6EA 2Q94A 2BHBA 2GG0A 1R58A 2ADUA 1CHMA 3MR1A 3Q6DA 2BN7A 4U6WA 4B28A 1QXZA 5FCHA 1XNZA 2BHAA 3RVAA 2GU4A 4U71A 2EA2A 1WL6A 1R5GA 3IU7A 4ZNGA 2EVOA 1BOAA 4RGZ1 2B3LA 4RZZA 4Z7MA 4U70A 3BIQA 3FM3A 2V3YA 3IU8A 4MATA 1PV9A 1Y1NA 4U6JA 3FMQA 3L24A 2GG7A 3L7GA 4FO7A 5JFRA 5JHUA 2BWYA 1C27A 2BWSA 4IKTA 1C21A 2HOWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2P99 A;  2P98 A;  1WN1 A;  2V3Z A;  2B3H A;  2GG5 A;  2GG3 A;  2Q95 A;  1QXW A;  1XGS A;  2BB7 A;  2EVC A;  3MX6 A;  4U76 A;  5E5B A;  1W2M A;  2IW2 A;  3IG4 A;  3PKC A;  4HXX A;  1C23 A;  3CB6 A;  2BHC A;  1WY2 A;  4A6V A;  4U6E A;  4U6C A;  2P9A A;  2GGC A;  2GTX A;  3TAV A;  2GA2 A;  2GZ5 A;  2GU5 A;  2OAZ A;  3BIP A;  2BWT A;  2BH3 A;  4FLJ A;  4PNC A;  4ZWO A;  5CIK A;  2EVM A;  1YJ3 A;  2BWW A;  1XGN A;  2BWV A;  4IDY A;  4ZWP A;  4PV4 A;  3CTZ A;  2GGB A;  1KQ9 A;  3PKE A;  5D6F A;  4FLI A;  4RZY A;  1QZY A;  4U6Z A;  2OKN A;  4R60 A;  4EGE A;  5CNX A;  2V3X A;  2GG2 A;  2Q92 A;  4IKU A;  1WKM A;  4S01 A;  1M35 A;  1A16 A;  1MAT A;  4JUQ A;  4U75 A;  1W7V A;  2NQ6 A;  3S6B A;  3PKD A;  2GU6 A;  2GG9 A;  4U1B A;  5FCF A;  4FLK A;  2BWU A;  2Q93 A;  1N51 A;  3MAT A;  1B6A A;  1XGO A;  1YW8 A;  3CB5 A;  3TB5 A;  1YW9 A;  1WLR A;  1KQ0 A;  4FUK A;  2GU7 A;  4IPA A;  2EA4 A;  2MAT A;  2NQ7 A;  4IU6 A;  4IF7 A;  4FLL A;  1BN5 A;  2GG8 A;  4ZWU A;  4OOK A;  1WBQ A;  2Q8K A;  5JI6 A;  2DFI A;  1KP0 A;  3BIT A;  2G6P A;  4S00 A;  1YVM A;  4IEC A;  3IU9 A;  4U69 A;  1C24 A;  4S2R P;  2V6C A;  2B3K A;  1B59 A;  3PKA A;  5CDV A;  4IKS A;  3PKB A;  4QR8 A;  2BWX A;  4IKR A;  1WL9 A;  1QXY A;  4FO8 A;  1O0X A;  4A6W A;  1JAW A;  1XGM A;  2Q96 A;  5CDL A;  5CE6 A;  5CDE A;  3FMR A;  4U73 A;  4FKC A;  4KM3 A;  3D27 A;  4S2T P;  1YW7 A;  1R5H A;  1C22 A;  3ROR A;  5CLS A;  2BHD A;  2ZSG A;  5D6E A;  2Q94 A;  2BHB A;  2GG0 A;  1R58 A;  2ADU A;  1CHM A;  3MR1 A;  3Q6D A;  2BN7 A;  4U6W A;  4B28 A;  1QXZ A;  5FCH A;  1XNZ A;  2BHA A;  3RVA A;  2GU4 A;  4U71 A;  2EA2 A;  1WL6 A;  1R5G A;  3IU7 A;  4ZNG A;  2EVO A;  1BOA A;  4RGZ 1;  2B3L A;  4RZZ A;  4Z7M A;  4U70 A;  3BIQ A;  3FM3 A;  2V3Y A;  3IU8 A;  4MAT A;  1PV9 A;  1Y1N A;  4U6J A;  3FMQ A;  3L24 A;  2GG7 A;  3L7G A;  4FO7 A;  5JFR A;  5JHU A;  2BWY A;  1C27 A;  2BWS A;  4IKT A;  1C21 A;  2HOW A; 
#chains in the Genus database with same CATH topology
 2P99 A;  2P98 A;  1WN1 A;  2V3Z A;  2B3H A;  2GG5 A;  2GG3 A;  2Q95 A;  1QXW A;  1XGS A;  2BB7 A;  2EVC A;  3MX6 A;  4U76 A;  5E5B A;  1W2M A;  2IW2 A;  3IG4 A;  3PKC A;  4HXX A;  1C23 A;  3CB6 A;  2BHC A;  1WY2 A;  4A6V A;  4U6E A;  4U6C A;  2P9A A;  2GGC A;  2GTX A;  3TAV A;  2GA2 A;  2GZ5 A;  2GU5 A;  2OAZ A;  3BIP A;  2BWT A;  2BH3 A;  4FLJ A;  4PNC A;  4ZWO A;  5CIK A;  2EVM A;  1YJ3 A;  2BWW A;  1XGN A;  2BWV A;  4IDY A;  4ZWP A;  4PV4 A;  3CTZ A;  2GGB A;  1KQ9 A;  3PKE A;  5D6F A;  4FLI A;  4RZY A;  1QZY A;  4U6Z A;  2OKN A;  4R60 A;  4EGE A;  5CNX A;  2V3X A;  2GG2 A;  2Q92 A;  4IKU A;  1WKM A;  4S01 A;  1M35 A;  1A16 A;  1MAT A;  4JUQ A;  4U75 A;  1W7V A;  2NQ6 A;  3S6B A;  3PKD A;  2GU6 A;  2GG9 A;  4U1B A;  5FCF A;  4FLK A;  2BWU A;  2Q93 A;  1N51 A;  3MAT A;  1B6A A;  1XGO A;  1YW8 A;  3CB5 A;  3TB5 A;  1YW9 A;  1WLR A;  1KQ0 A;  4FUK A;  2GU7 A;  4IPA A;  2EA4 A;  2MAT A;  2NQ7 A;  4IU6 A;  4IF7 A;  4FLL A;  1BN5 A;  2GG8 A;  4ZWU A;  4OOK A;  1WBQ A;  2Q8K A;  5JI6 A;  2DFI A;  1KP0 A;  3BIT A;  2G6P A;  4S00 A;  1YVM A;  4IEC A;  3IU9 A;  4U69 A;  1C24 A;  4S2R P;  2V6C A;  2B3K A;  1B59 A;  3PKA A;  5CDV A;  4IKS A;  3PKB A;  4QR8 A;  2BWX A;  4IKR A;  1WL9 A;  1QXY A;  4FO8 A;  1O0X A;  4A6W A;  1JAW A;  1XGM A;  2Q96 A;  5CDL A;  5CE6 A;  5CDE A;  3FMR A;  4U73 A;  4FKC A;  4KM3 A;  3D27 A;  4S2T P;  1YW7 A;  1R5H A;  1C22 A;  3ROR A;  5CLS A;  2BHD A;  2ZSG A;  5D6E A;  2Q94 A;  2BHB A;  2GG0 A;  1R58 A;  2ADU A;  1CHM A;  3MR1 A;  3Q6D A;  2BN7 A;  4U6W A;  4B28 A;  1QXZ A;  5FCH A;  1XNZ A;  2BHA A;  3RVA A;  2GU4 A;  4U71 A;  2EA2 A;  1WL6 A;  1R5G A;  3IU7 A;  4ZNG A;  2EVO A;  1BOA A;  4RGZ 1;  2B3L A;  4RZZ A;  4Z7M A;  4U70 A;  3BIQ A;  3FM3 A;  2V3Y A;  3IU8 A;  4MAT A;  1PV9 A;  1Y1N A;  4U6J A;  3FMQ A;  3L24 A;  2GG7 A;  3L7G A;  4FO7 A;  5JFR A;  5JHU A;  2BWY A;  1C27 A;  2BWS A;  4IKT A;  1C21 A;  2HOW A; 
#chains in the Genus database with same CATH homology
 2P99 A;  2P98 A;  1WN1 A;  2V3Z A;  2B3H A;  2GG5 A;  2GG3 A;  2Q95 A;  1QXW A;  1XGS A;  2BB7 A;  2EVC A;  3MX6 A;  4U76 A;  5E5B A;  1W2M A;  2IW2 A;  3IG4 A;  3PKC A;  4HXX A;  1C23 A;  3CB6 A;  2BHC A;  1WY2 A;  4A6V A;  4U6E A;  4U6C A;  2P9A A;  2GGC A;  2GTX A;  3TAV A;  2GA2 A;  2GZ5 A;  2GU5 A;  2OAZ A;  3BIP A;  2BWT A;  2BH3 A;  4FLJ A;  4PNC A;  4ZWO A;  5CIK A;  2EVM A;  1YJ3 A;  2BWW A;  1XGN A;  2BWV A;  4IDY A;  4ZWP A;  4PV4 A;  3CTZ A;  2GGB A;  1KQ9 A;  3PKE A;  5D6F A;  4FLI A;  4RZY A;  1QZY A;  4U6Z A;  2OKN A;  4R60 A;  4EGE A;  5CNX A;  2V3X A;  2GG2 A;  2Q92 A;  4IKU A;  1WKM A;  4S01 A;  1M35 A;  1A16 A;  1MAT A;  4JUQ A;  4U75 A;  1W7V A;  2NQ6 A;  3S6B A;  3PKD A;  2GU6 A;  2GG9 A;  4U1B A;  5FCF A;  4FLK A;  2BWU A;  2Q93 A;  1N51 A;  3MAT A;  1B6A A;  1XGO A;  1YW8 A;  3CB5 A;  3TB5 A;  1YW9 A;  1WLR A;  1KQ0 A;  4FUK A;  2GU7 A;  4IPA A;  2EA4 A;  2MAT A;  2NQ7 A;  4IU6 A;  4IF7 A;  4FLL A;  1BN5 A;  2GG8 A;  4ZWU A;  4OOK A;  1WBQ A;  2Q8K A;  5JI6 A;  2DFI A;  1KP0 A;  3BIT A;  2G6P A;  4S00 A;  1YVM A;  4IEC A;  3IU9 A;  4U69 A;  1C24 A;  4S2R P;  2V6C A;  2B3K A;  1B59 A;  3PKA A;  5CDV A;  4IKS A;  3PKB A;  4QR8 A;  2BWX A;  4IKR A;  1WL9 A;  1QXY A;  4FO8 A;  1O0X A;  4A6W A;  1JAW A;  1XGM A;  2Q96 A;  5CDL A;  5CE6 A;  5CDE A;  3FMR A;  4U73 A;  4FKC A;  4KM3 A;  3D27 A;  4S2T P;  1YW7 A;  1R5H A;  1C22 A;  3ROR A;  5CLS A;  2BHD A;  2ZSG A;  5D6E A;  2Q94 A;  2BHB A;  2GG0 A;  1R58 A;  2ADU A;  1CHM A;  3MR1 A;  3Q6D A;  2BN7 A;  4U6W A;  4B28 A;  1QXZ A;  5FCH A;  1XNZ A;  2BHA A;  3RVA A;  2GU4 A;  4U71 A;  2EA2 A;  1WL6 A;  1R5G A;  3IU7 A;  4ZNG A;  2EVO A;  1BOA A;  4RGZ 1;  2B3L A;  4RZZ A;  4Z7M A;  4U70 A;  3BIQ A;  3FM3 A;  2V3Y A;  3IU8 A;  4MAT A;  1PV9 A;  1Y1N A;  4U6J A;  3FMQ A;  3L24 A;  2GG7 A;  3L7G A;  4FO7 A;  5JFR A;  5JHU A;  2BWY A;  1C27 A;  2BWS A;  4IKT A;  1C21 A;  2HOW A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...