2BGDA

Structure-based design of protein tyrosine phosphatase-1b inhibitors
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
297
structure length
294
Chain Sequence
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Based Design of Protein Tyrosine Phosphatase-1B Inhibitors
pubmed doi rcsb
molecule keywords PROTEIN-TYROSINE PHOSPHATASE NON-RECEPTOR TYPE 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 105
structure length 294
sequence length 297
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2004-12-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2bgdA00
2OZ5A 2IMGA 2OC3A 3QCEA 3D1HA 4Z6BA 1A5YA 2P4DA 2Q05A 2I4EA 5GTJA 4JMKA 5K23A 1XRIA 2MBCA 2NT7A 4D3QA 4GFVA 1OEOX 1PH0A 1BZHA 2VEYA 3D1OA 5KA9A 4QBEA 3S4OA 1NO6A 3BLUA 1ONZA 1OEVA 3EB1A 4OHDA 3S3FA 3QKPA 1C88A 3BRHA 2PBNA 5K24A 4NNDA 3QCKA 3B7OA 3AWFA 2SHPA 2H4GA 3F99A 1OEUA 2B4UA 2CMBA 2VEWA 4WU3A 2J16B 4GE2A 2M3VA 1I9SA 4PVGA 2GWOA 4ZN5A 5MMZB 2H02A 2H4KA 2BGDA 4TVVA 1G1HA 2HC1A 1SUGA 4NYHA 1PXHA 5AWXA 1X24A 4KI9A 3S3EA 5KA4A 3NMEA 3U96A 3D42A 1WAXA 4QAPA 3O4SA 4GS0A 4H1OA 3EU0A 3D9CA 2I42A 1I9TA 3S3HA 2ZMMA 1C84A 4RHGA 3GXGA 1OEMX 2Y96A 1FPZA 3V0DA 3BM8A 2I6IA 1YFOA 4I8NA 1JLNA 1WRMA 3CM3A 4DGXA 1OETA 3RZ2A 2B3OA 1OESA 2CNEA 4WU2A 1FQ1A 2OOQA 2NLKA 2HNPA 4R0SA 5BZZA 2I3UA 1ZCLA 4NWGA 2F6TA 2DXPA 1C83A 4QBWA 1NNYA 5J8RA 1EEOA 2I4GA 2HNQA 2PA5A 2PT0A 1OHDA 4Y2EA 1BZCA 3MMJA 3GXHA 1XBOA 2RF6A 1WCHA 3BLTA 1AAXA 3D1QA 1P15A 4NX8A 2BV5A 5LXQB 3V0JA 1YN9A 1Q6SA 2QBRA 5KA1A 2Q47A 3QCBA 2JJDA 5K22A 4AZ1A 1ECVA 2R0BA 2PI7A 3QCJA 4H34A 4PYHA 3ZMQA 4GFUA 1LYVA 3V0HA 1EENA 2F6VA 1XXPA 1JF7A 2CMAA 2CJZA 2CNHA 4GRZA 3ZM3A 4DGPA 3QKQA 2I5XA 1NL9A 1C87A 3MOZA 5KA7A 1G7FA 2PSZA 2HCMA 4QUNA 1PA9A 2FH7A 2WGPA 1LARA 2CM7A 1M3GA 2QCTA 3QCMA 5K25A 1Q6PA 1YTSA 2VEXA 1KAKA 2GJTA 2YDUA 3N0AA 3RGOA 4GE5A 5KA2A 4WOHA 4GRYA 4IKCA 1GFYA 4YR8B 5KA3A 2HB1A 5M43A 1PTUA 4GWFA 4BJOA 1LQFA 2GP0A 2I4HA 1J4XA 4QUMA 4HJPA 4MBBA 5I6VA 4ERCA 2I6MA 1QXKA 2CMCA 2F6FA 1U25A 4D3PA 1U26A 5IBSA 2CNFA 1G4WR 4OHEA 2QBSA 2B4SA 3RGQA 1T49A 3ZV2A 1G4US 1YWFA 3EAXA 1Q6JA 3EMUA 5BUGA 1ZZWA 1D5RA 1I57A 4R0TA 1OHEA 1C85A 2BIJA 2HVLA 2BZLA 5EHPA 3S4EA 1Q1MA 2B07A 1GWZA 2J16A 4QAHA 2I6OA 1R6HA 3ZM0A 3AWEA 1RXDA 2H4VA 3M4UA 2C7SA 1ZCKA 4HJQA 2HXPA 4RDDA 5EHRA 5K9WA 5KAAA 2B4PA 2QCJA 2CFVA 5KADA 4R30A 1FPRA 3V0GA 3O3LA 4OHLA 1NWEA 5BX1A 1MKPA 4RKKA 2F71A 4KYRA 3OMHA 2QBPA 3LJ8A 3F81A 4JMJA 3QCHA 2C46A 2G59A 4HRFA 3QCIA 2I75A 2OUDA 4JBCA 1YTNA 2E0TA 1YGRA 3ZM1A 1Q6NA 2I6PA 1KAVA 4GE6A 2NV5A 2CM3A 3D44A 1Q6MA 3QCDA 4S0GA 2ZN7A 5BZXA 1YZ4A 1XM2A 1RPMA 2I3RA 4NWFA 2AHSA 2HY3A 2QDMA 1U24A 3O4TA 1G1FA 3I36A 1BZJA 4RI4A 2Y2FA 1YTWA 3V0EA 2QDPA 2BGEA 2F46A 5HDEA 1Q6TA 2F6ZA 4D3RA 1G7GA 2VEVA 1PYNA 5IBMA 2I6JA 4B04A 1PTTA 3V0FA 4RH9A 1T4JA 4ICZA 3I7ZA 1L8KA 2QEPA 2CM2A 1C86A 3AWGA 2CNGA 1T48A 3S3KA 3V0IA 3RO1A 3O5XA 4WTYA 1OHCA 5KA8A 5KACA 4OHHA 4ZRTA 3OLRA 4J51A 2CM8A 1YGUA 3QCCA 2H03A 3SMEA 1ONYA 4BPCA 5KA0A 3QCNA 4OHIA 3EZZA 4Y14A 1VHRA 2PQ5A 3A5JA 3CWEA 3F9BA 2CNIA 2J17A 4YAAA 1XXVA 4KYQA 1PTYA 2QDCA 2FJNA 4JNBA 1PTVA 2A8BA 2I1YA 3ZMPA 5KABA 1NZ7A 1YPTA 3QCGA 1V3AA 2F70A 2B4OA 2NTAA 4RH5A 2VEUA 3MOWA 1NWLA 1QZ0A 2FJMA 2A3KA 1L8GA 3ZM2A 4ZI4A 3I80A 3O4UA 3F9AA 3SR9A 1PA1A 3PS5A 3F41A 3QCLA 2AZRA 2P6XA 2NT2A 2F6WA 4RI5A 2NZ6A 2G6ZA 1G1GA 3H2XA 5K9VA 3QCFA 1ZC0A 3A5KA 2QBQA 2HC2A 2F6YA 2ESBA 2B49A 2H04A
chains in the Genus database with same CATH superfamily
2OZ5A 2IMGA 2OC3A 3QCEA 3ZM6A 3D1HA 4Z6BA 1A5YA 4C12A 1J6UA 2P4DA 2Q05A 2I4EA 5GTJA 4JMKA 5K23A 1XRIA 2MBCA 2NT7A 4D3QA 4CVKA 4GFVA 1OEOX 2Y66A 1PH0A 1BZHA 2VEYA 3D1OA 5KA9A 4QBEA 3S4OA 1NO6A 3BLUA 1ONZA 1OEVA 3EB1A 4OHDA 3S3FA 3QKPA 1C88A 3BRHA 2PBNA 5K24A 2Y1OA 4NNDA 3QCKA 1O5ZA 3B7OA 3AWFA 2SHPA 2H4GA 3F99A 1OEUA 2B4UA 2CMBA 2VEWA 4WU3A 2J16B 4GE2A 2M3VA 1I9SA 4PVGA 2GWOA 4ZN5A 5MMZB 2H02A 2H4KA 2BGDA 4TVVA 1G1HA 2HC1A 1SUGA 1E8CA 2GCBA 4NYHA 1PXHA 5AWXA 1X24A 4KI9A 3S3EA 5KA4A 3NMEA 3U96A 3D42A 1WAXA 4QAPA 3O4SA 4GS0A 4H1OA 3ZL8A 3EU0A 1JBWA 1W7KA 3D9CA 2I42A 1I9TA 3S3HA 2ZMMA 1C84A 4RHGA 3GXGA 1OEMX 2Y96A 5A5EA 2VOSA 1FPZA 3V0DA 4CVMA 3BM8A 2I6IA 1YFOA 2WJPA 4I8NA 1JLNA 1WRMA 2UUOA 3CM3A 4DGXA 1OETA 3RZ2A 2B3OA 1OESA 2CNEA 4WU2A 1FQ1A 1GQQA 2OOQA 2NLKA 2HNPA 2WTZA 4R0SA 5BZZA 2I3UA 1ZCLA 4NWGA 2F6TA 2DXPA 2GCAA 1C83A 4QBWA 1NNYA 5J8RA 1EEOA 2I4GA 2HNQA 2PA5A 2PT0A 1OHDA 4Y2EA 1BZCA 3MMJA 3GXHA 4CVLA 1W78A 1XBOA 2RF6A 1WCHA 3BLTA 1UAGA 1AAXA 3D1QA 1P15A 4NX8A 2BV5A 5LXQB 3V0JA 1YN9A 1Q6SA 2QBRA 5KA1A 2Q47A 3QCBA 2JJDA 5K22A 4AZ1A 1ECVA 2R0BA 3MVNA 2PI7A 2F00A 3NRSA 3QCJA 4H34A 4PYHA 3ZMQA 4GFUA 1LYVA 3V0HA 1EENA 2F6VA 1XXPA 1JF7A 2CMAA 2CJZA 2CNHA 3N2AA 4GRZA 3ZM3A 4DGPA 3QCZA 3QKQA 2I5XA 1NL9A 1C87A 3MOZA 5KA7A 1G7FA 2PSZA 2HCMA 4QUNA 1PA9A 2FH7A 2WGPA 1P3DA 1LARA 2CM7A 1M3GA 2VTDA 2QCTA 3QCMA 5K25A 1Q6PA 1YTSA 2VEXA 2X5OA 1KAKA 2GJTA 2YDUA 2XPCA 3N0AA 3RGOA 4GE5A 5KA2A 4WOHA 4GRYA 4IKCA 1GFYA 4YR8B 5KA3A 2HB1A 5M43A 2VTEA 1PTUA 4GWFA 4BJOA 1LQFA 1GG4A 2GP0A 2I4HA 1J4XA 4QUMA 4HJPA 4MBBA 5I6VA 2AM1A 1P31A 4ERCA 2I6MA 1QXKA 2CMCA 2F6FA 1U25A 4D3PA 1U26A 3LK7A 5IBSA 2CNFA 1G4WR 1E0DA 4OHEA 2QBSA 2B4SA 1FGSA 3RGQA 1T49A 3ZV2A 1G4US 1YWFA 3EAXA 1Q6JA 3EMUA 5BUGA 1ZZWA 1D5RA 1I57A 4R0TA 1OHEA 1C85A 2BIJA 2HVLA 2BZLA 5EHPA 5A5FA 3S4EA 1Q1MA 2B07A 1GWZA 2J16A 4QAHA 2I6OA 1R6HA 3ZM0A 3AWEA 1RXDA 2H4VA 3M4UA 2C7SA 1ZCKA 2VORA 2HXPA 4HJQA 4RDDA 5EHRA 5K9WA 5KAAA 2B4PA 2QCJA 2CFVA 5KADA 4R30A 1FPRA 3V0GA 3O3LA 4OHLA 1NWEA 5BX1A 1MKPA 4RKKA 2AM2A 2Y67A 2F71A 4KYRA 3OMHA 2QBPA 3LJ8A 3F81A 4JMJA 3QCHA 2C46A 2G59A 4HRFA 3QCIA 2I75A 2OUDA 4JBCA 1YTNA 2E0TA 1EEHA 1YGRA 3HN7A 4ZIYA 3ZM1A 1Q6NA 2UUPA 2I6PA 1KAVA 4GE6A 2NV5A 2CM3A 3D44A 1Q6MA 3QCDA 4S0GA 4QF5A 2ZN7A 5BZXA 1YZ4A 1XM2A 2UAGA 1RPMA 2I3RA 4NWFA 1JBVA 2AHSA 2HY3A 2QDMA 1U24A 4UAGA 3O4TA 1G1FA 3I36A 1BZJA 4RI4A 2Y2FA 1YTWA 3V0EA 2QDPA 2BGEA 2F46A 5HDEA 2JFFA 1Q6TA 2F6ZA 4D3RA 1G7GA 2VEVA 1PYNA 5IBMA 2I6JA 4B04A 1PTTA 3V0FA 4RH9A 1T4JA 2GC5A 4ICZA 3I7ZA 1L8KA 2QEPA 2CM2A 4HV4A 1C86A 3AWGA 2CNGA 1T48A 3S3KA 3V0IA 3RO1A 3O5XA 4WTYA 1OHCA 5KA8A 5KACA 2GC6A 4OHHA 4ZRTA 3OLRA 4J51A 2CM8A 1YGUA 3QCCA 2H03A 3SMEA 1ONYA 2XJAA 4BPCA 5KA0A 3QCNA 4QDIA 4OHIA 3PYZA 3EZZA 4Y14A 1VHRA 2PQ5A 3ZM5A 3A5JA 3CWEA 3F9BA 2CNIA 2J17A 4YAAA 1XXVA 4KYQA 3UAGA 1GQYA 1PTYA 2FJNA 2QDCA 4JNBA 1PTVA 2A8BA 2I1YA 3ZMPA 5KABA 1NZ7A 1YPTA 3QCGA 1V3AA 2F70A 2B4OA 2NTAA 4RH5A 4BUBA 2VEUA 2JFGA 3MOWA 1NWLA 1QZ0A 4BUCA 2FJMA 2Y68A 2A3KA 1L8GA 3ZM2A 4ZI4A 3I80A 3O4UA 3F9AA 3SR9A 1PA1A 3PS5A 3F41A 3QCLA 2AZRA 2P6XA 2NT2A 2F6WA 4RI5A 2NZ6A 2G6ZA 1G1GA 3H2XA 2JFHA 5K9VA 3QCFA 1ZC0A 4C13A 3A5KA 2QBQA 2HC2A 2F6YA 2ESBA 2B49A 2H04A
chains in the Genus database with same CATH topology
2OZ5A 2IMGA 2OC3A 3QCEA 3D1HA 4Z6BA 1A5YA 2P4DA 2Q05A 2I4EA 5GTJA 4JMKA 5K23A 1XRIA 2MBCA 2NT7A 4D3QA 4GFVA 1OEOX 1PH0A 1BZHA 2VEYA 3D1OA 5KA9A 4QBEA 3S4OA 1NO6A 3BLUA 1ONZA 1OEVA 3EB1A 4OHDA 3S3FA 3QKPA 1C88A 3BRHA 2PBNA 5K24A 4NNDA 3QCKA 3B7OA 3AWFA 2SHPA 2H4GA 3F99A 1OEUA 2B4UA 2CMBA 2VEWA 4WU3A 2J16B 4GE2A 2M3VA 1I9SA 4PVGA 2GWOA 4ZN5A 5MMZB 2H02A 2H4KA 2BGDA 4TVVA 1G1HA 2HC1A 1SUGA 4NYHA 1PXHA 5AWXA 1X24A 4KI9A 3S3EA 5KA4A 3NMEA 3U96A 3D42A 1WAXA 4QAPA 3O4SA 4GS0A 4H1OA 3EU0A 3D9CA 2I42A 1I9TA 3S3HA 2ZMMA 1C84A 4RHGA 3GXGA 1OEMX 2Y96A 1FPZA 3V0DA 3BM8A 2I6IA 1YFOA 4I8NA 1JLNA 1WRMA 3CM3A 4DGXA 1OETA 3RZ2A 2B3OA 1OESA 2CNEA 4WU2A 1FQ1A 2OOQA 2NLKA 2HNPA 4R0SA 5BZZA 2I3UA 1ZCLA 4NWGA 2F6TA 2DXPA 1C83A 4QBWA 1NNYA 5J8RA 1EEOA 2I4GA 2HNQA 2PA5A 2PT0A 1OHDA 4Y2EA 1BZCA 3MMJA 3GXHA 1XBOA 2RF6A 1WCHA 3BLTA 1AAXA 3D1QA 1P15A 4NX8A 2BV5A 5LXQB 3V0JA 1YN9A 1Q6SA 2QBRA 5KA1A 2Q47A 3QCBA 2JJDA 5K22A 4AZ1A 1ECVA 2R0BA 2PI7A 3QCJA 4H34A 4PYHA 3ZMQA 4GFUA 1LYVA 3V0HA 1EENA 2F6VA 1XXPA 1JF7A 2CMAA 2CJZA 2CNHA 4GRZA 3ZM3A 4DGPA 3QKQA 2I5XA 1NL9A 1C87A 3MOZA 5KA7A 1G7FA 2PSZA 2HCMA 4QUNA 1PA9A 2FH7A 2WGPA 1LARA 2CM7A 1M3GA 2QCTA 3QCMA 5K25A 1Q6PA 1YTSA 2VEXA 1KAKA 2GJTA 2YDUA 3N0AA 3RGOA 4GE5A 5KA2A 4WOHA 4GRYA 4IKCA 1GFYA 4YR8B 5KA3A 2HB1A 5M43A 1PTUA 4GWFA 4BJOA 1LQFA 2GP0A 2I4HA 1J4XA 4QUMA 4HJPA 4MBBA 5I6VA 4ERCA 2I6MA 1QXKA 2CMCA 2F6FA 1U25A 4D3PA 1U26A 5IBSA 2CNFA 1G4WR 4OHEA 2QBSA 2B4SA 3RGQA 1T49A 3ZV2A 1G4US 1YWFA 3EAXA 1Q6JA 3EMUA 5BUGA 1ZZWA 1D5RA 1I57A 4R0TA 1OHEA 1C85A 2BIJA 2HVLA 2BZLA 5EHPA 3S4EA 1Q1MA 2B07A 1GWZA 2J16A 4QAHA 2I6OA 1R6HA 3ZM0A 3AWEA 1RXDA 2H4VA 3M4UA 2C7SA 1ZCKA 4HJQA 2HXPA 4RDDA 5EHRA 5K9WA 5KAAA 2B4PA 2QCJA 2CFVA 5KADA 4R30A 1FPRA 3V0GA 3O3LA 4OHLA 1NWEA 5BX1A 1MKPA 4RKKA 2F71A 4KYRA 3OMHA 2QBPA 3LJ8A 3F81A 4JMJA 3QCHA 2C46A 2G59A 4HRFA 3QCIA 2I75A 2OUDA 4JBCA 1YTNA 2E0TA 1YGRA 3ZM1A 1Q6NA 2I6PA 1KAVA 4GE6A 2NV5A 2CM3A 3D44A 1Q6MA 3QCDA 4S0GA 2ZN7A 5BZXA 1YZ4A 1XM2A 1RPMA 2I3RA 4NWFA 2AHSA 2HY3A 2QDMA 1U24A 3O4TA 1G1FA 3I36A 1BZJA 4RI4A 2Y2FA 1YTWA 3V0EA 2QDPA 2BGEA 2F46A 5HDEA 1Q6TA 2F6ZA 4D3RA 1G7GA 2VEVA 1PYNA 5IBMA 2I6JA 4B04A 1PTTA 3V0FA 4RH9A 1T4JA 4ICZA 3I7ZA 1L8KA 2QEPA 2CM2A 1C86A 3AWGA 2CNGA 1T48A 3S3KA 3V0IA 3RO1A 3O5XA 4WTYA 1OHCA 5KA8A 5KACA 4OHHA 4ZRTA 3OLRA 4J51A 2CM8A 1YGUA 3QCCA 2H03A 3SMEA 1ONYA 4BPCA 5KA0A 3QCNA 4OHIA 3EZZA 4Y14A 1VHRA 2PQ5A 3A5JA 3CWEA 3F9BA 2CNIA 2J17A 4YAAA 1XXVA 4KYQA 1PTYA 2QDCA 2FJNA 4JNBA 1PTVA 2A8BA 2I1YA 3ZMPA 5KABA 1NZ7A 1YPTA 3QCGA 1V3AA 2F70A 2B4OA 2NTAA 4RH5A 2VEUA 3MOWA 1NWLA 1QZ0A 2FJMA 2A3KA 1L8GA 3ZM2A 4ZI4A 3I80A 3O4UA 3F9AA 3SR9A 1PA1A 3PS5A 3F41A 3QCLA 2AZRA 2P6XA 2NT2A 2F6WA 4RI5A 2NZ6A 2G6ZA 1G1GA 3H2XA 5K9VA 3QCFA 1ZC0A 3A5KA 2QBQA 2HC2A 2F6YA 2ESBA 2B49A 2H04A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OZ5 A;  2IMG A;  2OC3 A;  3QCE A;  3D1H A;  4Z6B A;  1A5Y A;  2P4D A;  2Q05 A;  2I4E A;  5GTJ A;  4JMK A;  5K23 A;  1XRI A;  2MBC A;  2NT7 A;  4D3Q A;  4GFV A;  1OEO X;  1PH0 A;  1BZH A;  2VEY A;  3D1O A;  5KA9 A;  4QBE A;  3S4O A;  1NO6 A;  3BLU A;  1ONZ A;  1OEV A;  3EB1 A;  4OHD A;  3S3F A;  3QKP A;  1C88 A;  3BRH A;  2PBN A;  5K24 A;  4NND A;  3QCK A;  3B7O A;  3AWF A;  2SHP A;  2H4G A;  3F99 A;  1OEU A;  2B4U A;  2CMB A;  2VEW A;  4WU3 A;  2J16 B;  4GE2 A;  2M3V A;  1I9S A;  4PVG A;  2GWO A;  4ZN5 A;  5MMZ B;  2H02 A;  2H4K A;  2BGD A;  4TVV A;  1G1H A;  2HC1 A;  1SUG A;  4NYH A;  1PXH A;  5AWX A;  1X24 A;  4KI9 A;  3S3E A;  5KA4 A;  3NME A;  3U96 A;  3D42 A;  1WAX A;  4QAP A;  3O4S A;  4GS0 A;  4H1O A;  3EU0 A;  3D9C A;  2I42 A;  1I9T A;  3S3H A;  2ZMM A;  1C84 A;  4RHG A;  3GXG A;  1OEM X;  2Y96 A;  1FPZ A;  3V0D A;  3BM8 A;  2I6I A;  1YFO A;  4I8N A;  1JLN A;  1WRM A;  3CM3 A;  4DGX A;  1OET A;  3RZ2 A;  2B3O A;  1OES A;  2CNE A;  4WU2 A;  1FQ1 A;  2OOQ A;  2NLK A;  2HNP A;  4R0S A;  5BZZ A;  2I3U A;  1ZCL A;  4NWG A;  2F6T A;  2DXP A;  1C83 A;  4QBW A;  1NNY A;  5J8R A;  1EEO A;  2I4G A;  2HNQ A;  2PA5 A;  2PT0 A;  1OHD A;  4Y2E A;  1BZC A;  3MMJ A;  3GXH A;  1XBO A;  2RF6 A;  1WCH A;  3BLT A;  1AAX A;  3D1Q A;  1P15 A;  4NX8 A;  2BV5 A;  5LXQ B;  3V0J A;  1YN9 A;  1Q6S A;  2QBR A;  5KA1 A;  2Q47 A;  3QCB A;  2JJD A;  5K22 A;  4AZ1 A;  1ECV A;  2R0B A;  2PI7 A;  3QCJ A;  4H34 A;  4PYH A;  3ZMQ A;  4GFU A;  1LYV A;  3V0H A;  1EEN A;  2F6V A;  1XXP A;  1JF7 A;  2CMA A;  2CJZ A;  2CNH A;  4GRZ A;  3ZM3 A;  4DGP A;  3QKQ A;  2I5X A;  1NL9 A;  1C87 A;  3MOZ A;  5KA7 A;  1G7F A;  2PSZ A;  2HCM A;  4QUN A;  1PA9 A;  2FH7 A;  2WGP A;  1LAR A;  2CM7 A;  1M3G A;  2QCT A;  3QCM A;  5K25 A;  1Q6P A;  1YTS A;  2VEX A;  1KAK A;  2GJT A;  2YDU A;  3N0A A;  3RGO A;  4GE5 A;  5KA2 A;  4WOH A;  4GRY A;  4IKC A;  1GFY A;  4YR8 B;  5KA3 A;  2HB1 A;  5M43 A;  1PTU A;  4GWF A;  4BJO A;  1LQF A;  2GP0 A;  2I4H A;  1J4X A;  4QUM A;  4HJP A;  4MBB A;  5I6V A;  4ERC A;  2I6M A;  1QXK A;  2CMC A;  2F6F A;  1U25 A;  4D3P A;  1U26 A;  5IBS A;  2CNF A;  1G4W R;  4OHE A;  2QBS A;  2B4S A;  3RGQ A;  1T49 A;  3ZV2 A;  1G4U S;  1YWF A;  3EAX A;  1Q6J A;  3EMU A;  5BUG A;  1ZZW A;  1D5R A;  1I57 A;  4R0T A;  1OHE A;  1C85 A;  2BIJ A;  2HVL A;  2BZL A;  5EHP A;  3S4E A;  1Q1M A;  2B07 A;  1GWZ A;  2J16 A;  4QAH A;  2I6O A;  1R6H A;  3ZM0 A;  3AWE A;  1RXD A;  2H4V A;  3M4U A;  2C7S A;  1ZCK A;  4HJQ A;  2HXP A;  4RDD A;  5EHR A;  5K9W A;  5KAA A;  2B4P A;  2QCJ A;  2CFV A;  5KAD A;  4R30 A;  1FPR A;  3V0G A;  3O3L A;  4OHL A;  1NWE A;  5BX1 A;  1MKP A;  4RKK A;  2F71 A;  4KYR A;  3OMH A;  2QBP A;  3LJ8 A;  3F81 A;  4JMJ A;  3QCH A;  2C46 A;  2G59 A;  4HRF A;  3QCI A;  2I75 A;  2OUD A;  4JBC A;  1YTN A;  2E0T A;  1YGR A;  3ZM1 A;  1Q6N A;  2I6P A;  1KAV A;  4GE6 A;  2NV5 A;  2CM3 A;  3D44 A;  1Q6M A;  3QCD A;  4S0G A;  2ZN7 A;  5BZX A;  1YZ4 A;  1XM2 A;  1RPM A;  2I3R A;  4NWF A;  2AHS A;  2HY3 A;  2QDM A;  1U24 A;  3O4T A;  1G1F A;  3I36 A;  1BZJ A;  4RI4 A;  2Y2F A;  1YTW A;  3V0E A;  2QDP A;  2BGE A;  2F46 A;  5HDE A;  1Q6T A;  2F6Z A;  4D3R A;  1G7G A;  2VEV A;  1PYN A;  5IBM A;  2I6J A;  4B04 A;  1PTT A;  3V0F A;  4RH9 A;  1T4J A;  4ICZ A;  3I7Z A;  1L8K A;  2QEP A;  2CM2 A;  1C86 A;  3AWG A;  2CNG A;  1T48 A;  3S3K A;  3V0I A;  3RO1 A;  3O5X A;  4WTY A;  1OHC A;  5KA8 A;  5KAC A;  4OHH A;  4ZRT A;  3OLR A;  4J51 A;  2CM8 A;  1YGU A;  3QCC A;  2H03 A;  3SME A;  1ONY A;  4BPC A;  5KA0 A;  3QCN A;  4OHI A;  3EZZ A;  4Y14 A;  1VHR A;  2PQ5 A;  3A5J A;  3CWE A;  3F9B A;  2CNI A;  2J17 A;  4YAA A;  1XXV A;  4KYQ A;  1PTY A;  2QDC A;  2FJN A;  4JNB A;  1PTV A;  2A8B A;  2I1Y A;  3ZMP A;  5KAB A;  1NZ7 A;  1YPT A;  3QCG A;  1V3A A;  2F70 A;  2B4O A;  2NTA A;  4RH5 A;  2VEU A;  3MOW A;  1NWL A;  1QZ0 A;  2FJM A;  2A3K A;  1L8G A;  3ZM2 A;  4ZI4 A;  3I80 A;  3O4U A;  3F9A A;  3SR9 A;  1PA1 A;  3PS5 A;  3F41 A;  3QCL A;  2AZR A;  2P6X A;  2NT2 A;  2F6W A;  4RI5 A;  2NZ6 A;  2G6Z A;  1G1G A;  3H2X A;  5K9V A;  3QCF A;  1ZC0 A;  3A5K A;  2QBQ A;  2HC2 A;  2F6Y A;  2ESB A;  2B49 A;  2H04 A; 
#chains in the Genus database with same CATH topology
 2OZ5 A;  2IMG A;  2OC3 A;  3QCE A;  3ZM6 A;  3D1H A;  4Z6B A;  1A5Y A;  4C12 A;  1J6U A;  2P4D A;  2Q05 A;  2I4E A;  5GTJ A;  4JMK A;  5K23 A;  1XRI A;  2MBC A;  2NT7 A;  4D3Q A;  4CVK A;  4GFV A;  1OEO X;  2Y66 A;  1PH0 A;  1BZH A;  2VEY A;  3D1O A;  5KA9 A;  4QBE A;  3S4O A;  1NO6 A;  3BLU A;  1ONZ A;  1OEV A;  3EB1 A;  4OHD A;  3S3F A;  3QKP A;  1C88 A;  3BRH A;  2PBN A;  5K24 A;  2Y1O A;  4NND A;  3QCK A;  1O5Z A;  3B7O A;  3AWF A;  2SHP A;  2H4G A;  3F99 A;  1OEU A;  2B4U A;  2CMB A;  2VEW A;  4WU3 A;  2J16 B;  4GE2 A;  2M3V A;  1I9S A;  4PVG A;  2GWO A;  4ZN5 A;  5MMZ B;  2H02 A;  2H4K A;  2BGD A;  4TVV A;  1G1H A;  2HC1 A;  1SUG A;  1E8C A;  2GCB A;  4NYH A;  1PXH A;  5AWX A;  1X24 A;  4KI9 A;  3S3E A;  5KA4 A;  3NME A;  3U96 A;  3D42 A;  1WAX A;  4QAP A;  3O4S A;  4GS0 A;  4H1O A;  3ZL8 A;  3EU0 A;  1JBW A;  1W7K A;  3D9C A;  2I42 A;  1I9T A;  3S3H A;  2ZMM A;  1C84 A;  4RHG A;  3GXG A;  1OEM X;  2Y96 A;  5A5E A;  2VOS A;  1FPZ A;  3V0D A;  4CVM A;  3BM8 A;  2I6I A;  1YFO A;  2WJP A;  4I8N A;  1JLN A;  1WRM A;  2UUO A;  3CM3 A;  4DGX A;  1OET A;  3RZ2 A;  2B3O A;  1OES A;  2CNE A;  4WU2 A;  1FQ1 A;  1GQQ A;  2OOQ A;  2NLK A;  2HNP A;  2WTZ A;  4R0S A;  5BZZ A;  2I3U A;  1ZCL A;  4NWG A;  2F6T A;  2DXP A;  2GCA A;  1C83 A;  4QBW A;  1NNY A;  5J8R A;  1EEO A;  2I4G A;  2HNQ A;  2PA5 A;  2PT0 A;  1OHD A;  4Y2E A;  1BZC A;  3MMJ A;  3GXH A;  4CVL A;  1W78 A;  1XBO A;  2RF6 A;  1WCH A;  3BLT A;  1UAG A;  1AAX A;  3D1Q A;  1P15 A;  4NX8 A;  2BV5 A;  5LXQ B;  3V0J A;  1YN9 A;  1Q6S A;  2QBR A;  5KA1 A;  2Q47 A;  3QCB A;  2JJD A;  5K22 A;  4AZ1 A;  1ECV A;  2R0B A;  3MVN A;  2PI7 A;  2F00 A;  3NRS A;  3QCJ A;  4H34 A;  4PYH A;  3ZMQ A;  4GFU A;  1LYV A;  3V0H A;  1EEN A;  2F6V A;  1XXP A;  1JF7 A;  2CMA A;  2CJZ A;  2CNH A;  3N2A A;  4GRZ A;  3ZM3 A;  4DGP A;  3QCZ A;  3QKQ A;  2I5X A;  1NL9 A;  1C87 A;  3MOZ A;  5KA7 A;  1G7F A;  2PSZ A;  2HCM A;  4QUN A;  1PA9 A;  2FH7 A;  2WGP A;  1P3D A;  1LAR A;  2CM7 A;  1M3G A;  2VTD A;  2QCT A;  3QCM A;  5K25 A;  1Q6P A;  1YTS A;  2VEX A;  2X5O A;  1KAK A;  2GJT A;  2YDU A;  2XPC A;  3N0A A;  3RGO A;  4GE5 A;  5KA2 A;  4WOH A;  4GRY A;  4IKC A;  1GFY A;  4YR8 B;  5KA3 A;  2HB1 A;  5M43 A;  2VTE A;  1PTU A;  4GWF A;  4BJO A;  1LQF A;  1GG4 A;  2GP0 A;  2I4H A;  1J4X A;  4QUM A;  4HJP A;  4MBB A;  5I6V A;  2AM1 A;  1P31 A;  4ERC A;  2I6M A;  1QXK A;  2CMC A;  2F6F A;  1U25 A;  4D3P A;  1U26 A;  3LK7 A;  5IBS A;  2CNF A;  1G4W R;  1E0D A;  4OHE A;  2QBS A;  2B4S A;  1FGS A;  3RGQ A;  1T49 A;  3ZV2 A;  1G4U S;  1YWF A;  3EAX A;  1Q6J A;  3EMU A;  5BUG A;  1ZZW A;  1D5R A;  1I57 A;  4R0T A;  1OHE A;  1C85 A;  2BIJ A;  2HVL A;  2BZL A;  5EHP A;  5A5F A;  3S4E A;  1Q1M A;  2B07 A;  1GWZ A;  2J16 A;  4QAH A;  2I6O A;  1R6H A;  3ZM0 A;  3AWE A;  1RXD A;  2H4V A;  3M4U A;  2C7S A;  1ZCK A;  2VOR A;  2HXP A;  4HJQ A;  4RDD A;  5EHR A;  5K9W A;  5KAA A;  2B4P A;  2QCJ A;  2CFV A;  5KAD A;  4R30 A;  1FPR A;  3V0G A;  3O3L A;  4OHL A;  1NWE A;  5BX1 A;  1MKP A;  4RKK A;  2AM2 A;  2Y67 A;  2F71 A;  4KYR A;  3OMH A;  2QBP A;  3LJ8 A;  3F81 A;  4JMJ A;  3QCH A;  2C46 A;  2G59 A;  4HRF A;  3QCI A;  2I75 A;  2OUD A;  4JBC A;  1YTN A;  2E0T A;  1EEH A;  1YGR A;  3HN7 A;  4ZIY A;  3ZM1 A;  1Q6N A;  2UUP A;  2I6P A;  1KAV A;  4GE6 A;  2NV5 A;  2CM3 A;  3D44 A;  1Q6M A;  3QCD A;  4S0G A;  4QF5 A;  2ZN7 A;  5BZX A;  1YZ4 A;  1XM2 A;  2UAG A;  1RPM A;  2I3R A;  4NWF A;  1JBV A;  2AHS A;  2HY3 A;  2QDM A;  1U24 A;  4UAG A;  3O4T A;  1G1F A;  3I36 A;  1BZJ A;  4RI4 A;  2Y2F A;  1YTW A;  3V0E A;  2QDP A;  2BGE A;  2F46 A;  5HDE A;  2JFF A;  1Q6T A;  2F6Z A;  4D3R A;  1G7G A;  2VEV A;  1PYN A;  5IBM A;  2I6J A;  4B04 A;  1PTT A;  3V0F A;  4RH9 A;  1T4J A;  2GC5 A;  4ICZ A;  3I7Z A;  1L8K A;  2QEP A;  2CM2 A;  4HV4 A;  1C86 A;  3AWG A;  2CNG A;  1T48 A;  3S3K A;  3V0I A;  3RO1 A;  3O5X A;  4WTY A;  1OHC A;  5KA8 A;  5KAC A;  2GC6 A;  4OHH A;  4ZRT A;  3OLR A;  4J51 A;  2CM8 A;  1YGU A;  3QCC A;  2H03 A;  3SME A;  1ONY A;  2XJA A;  4BPC A;  5KA0 A;  3QCN A;  4QDI A;  4OHI A;  3PYZ A;  3EZZ A;  4Y14 A;  1VHR A;  2PQ5 A;  3ZM5 A;  3A5J A;  3CWE A;  3F9B A;  2CNI A;  2J17 A;  4YAA A;  1XXV A;  4KYQ A;  3UAG A;  1GQY A;  1PTY A;  2FJN A;  2QDC A;  4JNB A;  1PTV A;  2A8B A;  2I1Y A;  3ZMP A;  5KAB A;  1NZ7 A;  1YPT A;  3QCG A;  1V3A A;  2F70 A;  2B4O A;  2NTA A;  4RH5 A;  4BUB A;  2VEU A;  2JFG A;  3MOW A;  1NWL A;  1QZ0 A;  4BUC A;  2FJM A;  2Y68 A;  2A3K A;  1L8G A;  3ZM2 A;  4ZI4 A;  3I80 A;  3O4U A;  3F9A A;  3SR9 A;  1PA1 A;  3PS5 A;  3F41 A;  3QCL A;  2AZR A;  2P6X A;  2NT2 A;  2F6W A;  4RI5 A;  2NZ6 A;  2G6Z A;  1G1G A;  3H2X A;  2JFH A;  5K9V A;  3QCF A;  1ZC0 A;  4C13 A;  3A5K A;  2QBQ A;  2HC2 A;  2F6Y A;  2ESB A;  2B49 A;  2H04 A; 
#chains in the Genus database with same CATH homology
 2OZ5 A;  2IMG A;  2OC3 A;  3QCE A;  3D1H A;  4Z6B A;  1A5Y A;  2P4D A;  2Q05 A;  2I4E A;  5GTJ A;  4JMK A;  5K23 A;  1XRI A;  2MBC A;  2NT7 A;  4D3Q A;  4GFV A;  1OEO X;  1PH0 A;  1BZH A;  2VEY A;  3D1O A;  5KA9 A;  4QBE A;  3S4O A;  1NO6 A;  3BLU A;  1ONZ A;  1OEV A;  3EB1 A;  4OHD A;  3S3F A;  3QKP A;  1C88 A;  3BRH A;  2PBN A;  5K24 A;  4NND A;  3QCK A;  3B7O A;  3AWF A;  2SHP A;  2H4G A;  3F99 A;  1OEU A;  2B4U A;  2CMB A;  2VEW A;  4WU3 A;  2J16 B;  4GE2 A;  2M3V A;  1I9S A;  4PVG A;  2GWO A;  4ZN5 A;  5MMZ B;  2H02 A;  2H4K A;  2BGD A;  4TVV A;  1G1H A;  2HC1 A;  1SUG A;  4NYH A;  1PXH A;  5AWX A;  1X24 A;  4KI9 A;  3S3E A;  5KA4 A;  3NME A;  3U96 A;  3D42 A;  1WAX A;  4QAP A;  3O4S A;  4GS0 A;  4H1O A;  3EU0 A;  3D9C A;  2I42 A;  1I9T A;  3S3H A;  2ZMM A;  1C84 A;  4RHG A;  3GXG A;  1OEM X;  2Y96 A;  1FPZ A;  3V0D A;  3BM8 A;  2I6I A;  1YFO A;  4I8N A;  1JLN A;  1WRM A;  3CM3 A;  4DGX A;  1OET A;  3RZ2 A;  2B3O A;  1OES A;  2CNE A;  4WU2 A;  1FQ1 A;  2OOQ A;  2NLK A;  2HNP A;  4R0S A;  5BZZ A;  2I3U A;  1ZCL A;  4NWG A;  2F6T A;  2DXP A;  1C83 A;  4QBW A;  1NNY A;  5J8R A;  1EEO A;  2I4G A;  2HNQ A;  2PA5 A;  2PT0 A;  1OHD A;  4Y2E A;  1BZC A;  3MMJ A;  3GXH A;  1XBO A;  2RF6 A;  1WCH A;  3BLT A;  1AAX A;  3D1Q A;  1P15 A;  4NX8 A;  2BV5 A;  5LXQ B;  3V0J A;  1YN9 A;  1Q6S A;  2QBR A;  5KA1 A;  2Q47 A;  3QCB A;  2JJD A;  5K22 A;  4AZ1 A;  1ECV A;  2R0B A;  2PI7 A;  3QCJ A;  4H34 A;  4PYH A;  3ZMQ A;  4GFU A;  1LYV A;  3V0H A;  1EEN A;  2F6V A;  1XXP A;  1JF7 A;  2CMA A;  2CJZ A;  2CNH A;  4GRZ A;  3ZM3 A;  4DGP A;  3QKQ A;  2I5X A;  1NL9 A;  1C87 A;  3MOZ A;  5KA7 A;  1G7F A;  2PSZ A;  2HCM A;  4QUN A;  1PA9 A;  2FH7 A;  2WGP A;  1LAR A;  2CM7 A;  1M3G A;  2QCT A;  3QCM A;  5K25 A;  1Q6P A;  1YTS A;  2VEX A;  1KAK A;  2GJT A;  2YDU A;  3N0A A;  3RGO A;  4GE5 A;  5KA2 A;  4WOH A;  4GRY A;  4IKC A;  1GFY A;  4YR8 B;  5KA3 A;  2HB1 A;  5M43 A;  1PTU A;  4GWF A;  4BJO A;  1LQF A;  2GP0 A;  2I4H A;  1J4X A;  4QUM A;  4HJP A;  4MBB A;  5I6V A;  4ERC A;  2I6M A;  1QXK A;  2CMC A;  2F6F A;  1U25 A;  4D3P A;  1U26 A;  5IBS A;  2CNF A;  1G4W R;  4OHE A;  2QBS A;  2B4S A;  3RGQ A;  1T49 A;  3ZV2 A;  1G4U S;  1YWF A;  3EAX A;  1Q6J A;  3EMU A;  5BUG A;  1ZZW A;  1D5R A;  1I57 A;  4R0T A;  1OHE A;  1C85 A;  2BIJ A;  2HVL A;  2BZL A;  5EHP A;  3S4E A;  1Q1M A;  2B07 A;  1GWZ A;  2J16 A;  4QAH A;  2I6O A;  1R6H A;  3ZM0 A;  3AWE A;  1RXD A;  2H4V A;  3M4U A;  2C7S A;  1ZCK A;  4HJQ A;  2HXP A;  4RDD A;  5EHR A;  5K9W A;  5KAA A;  2B4P A;  2QCJ A;  2CFV A;  5KAD A;  4R30 A;  1FPR A;  3V0G A;  3O3L A;  4OHL A;  1NWE A;  5BX1 A;  1MKP A;  4RKK A;  2F71 A;  4KYR A;  3OMH A;  2QBP A;  3LJ8 A;  3F81 A;  4JMJ A;  3QCH A;  2C46 A;  2G59 A;  4HRF A;  3QCI A;  2I75 A;  2OUD A;  4JBC A;  1YTN A;  2E0T A;  1YGR A;  3ZM1 A;  1Q6N A;  2I6P A;  1KAV A;  4GE6 A;  2NV5 A;  2CM3 A;  3D44 A;  1Q6M A;  3QCD A;  4S0G A;  2ZN7 A;  5BZX A;  1YZ4 A;  1XM2 A;  1RPM A;  2I3R A;  4NWF A;  2AHS A;  2HY3 A;  2QDM A;  1U24 A;  3O4T A;  1G1F A;  3I36 A;  1BZJ A;  4RI4 A;  2Y2F A;  1YTW A;  3V0E A;  2QDP A;  2BGE A;  2F46 A;  5HDE A;  1Q6T A;  2F6Z A;  4D3R A;  1G7G A;  2VEV A;  1PYN A;  5IBM A;  2I6J A;  4B04 A;  1PTT A;  3V0F A;  4RH9 A;  1T4J A;  4ICZ A;  3I7Z A;  1L8K A;  2QEP A;  2CM2 A;  1C86 A;  3AWG A;  2CNG A;  1T48 A;  3S3K A;  3V0I A;  3RO1 A;  3O5X A;  4WTY A;  1OHC A;  5KA8 A;  5KAC A;  4OHH A;  4ZRT A;  3OLR A;  4J51 A;  2CM8 A;  1YGU A;  3QCC A;  2H03 A;  3SME A;  1ONY A;  4BPC A;  5KA0 A;  3QCN A;  4OHI A;  3EZZ A;  4Y14 A;  1VHR A;  2PQ5 A;  3A5J A;  3CWE A;  3F9B A;  2CNI A;  2J17 A;  4YAA A;  1XXV A;  4KYQ A;  1PTY A;  2QDC A;  2FJN A;  4JNB A;  1PTV A;  2A8B A;  2I1Y A;  3ZMP A;  5KAB A;  1NZ7 A;  1YPT A;  3QCG A;  1V3A A;  2F70 A;  2B4O A;  2NTA A;  4RH5 A;  2VEU A;  3MOW A;  1NWL A;  1QZ0 A;  2FJM A;  2A3K A;  1L8G A;  3ZM2 A;  4ZI4 A;  3I80 A;  3O4U A;  3F9A A;  3SR9 A;  1PA1 A;  3PS5 A;  3F41 A;  3QCL A;  2AZR A;  2P6X A;  2NT2 A;  2F6W A;  4RI5 A;  2NZ6 A;  2G6Z A;  1G1G A;  3H2X A;  5K9V A;  3QCF A;  1ZC0 A;  3A5K A;  2QBQ A;  2HC2 A;  2F6Y A;  2ESB A;  2B49 A;  2H04 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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