2CLAA

Crystal structure of the asp-199-asn mutant of chloramphenicol acetyltransferase to 2.35 angstroms resolution. structural consequences of disruption of a buried salt-bridge
Total Genus 55
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
213
structure length
213
Chain Sequence
MNYTKFDVKNWVRREHFEFYRHRLPCGFSLTSKIDITTLKKSLDDSAYKFYPVMIYLIAQAVNQFDELRMAIKDDELIVWDSVDPQFTVFHQETETFSALSCPYSSDIDQFMVNYLSVMERYKSDTKLFPQGVTPENHLNISALPWVNFDSFNLNVANFTDYFAPIITMAKYQQEGDRLLLPLSVQVHHAVCNGFHVARFINRLQELCNSKLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Crystal structure of the aspartic acid-199----asparagine mutant of chloramphenicol acetyltransferase to 2.35-A resolution: structural consequences of disruption of a buried salt bridge.
pubmed doi rcsb
molecule tags Transferase (acyltransferase)
source organism Escherichia coli
molecule keywords CHLORAMPHENICOL ACETYLTRANSFERASE
total genus 55
structure length 213
sequence length 213
ec nomenclature ec 2.3.1.28: Chloramphenicol O-acetyltransferase.
pdb deposition date 1990-04-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00302 CAT Chloramphenicol acetyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.10 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol acetyltransferase-like domain 2claA00
1XMCA 5DU9A 4JN3A 4JN5A 4KE4A 5KJVA 1XL8A 2II4A 2RKVA 2VSQA 3B30A 1EAFA 1EAAA 1QCAA 2I9DA 5KJSA 1CIAA 4HVMA 1Q23A 1XMDA 2CLAA 2JGPA 4N72A 2E1UA 1E2OA 2II5A 2ZBAA 2BGHA 3U9BA 1SCZA 1DPCA 2E1TA 3FP0A 3MAEA 1EACA 1NOCB 1C4TA 1Q9JA 1PD5A 3CLAA 1DPBA 5FALA 2XHGA 2XR7A 5KJUA 1XL7A 2IHWA 1CLAA 4CLAA 4G22A 5KJTA 2RKTA 5DUAA 5KJWA 5FANA 1EABA 1L5AA 4G0BA 3U9FA 2II3A 3B2SA 5T3EA 4G2MA 3FOTA 1EADA 1EAEA 3L60A 1DPDA 2E1VA 4KECA
chains in the Genus database with same CATH superfamily
5DU9A 4JN3A 1T7QA 4JN5A 4EP9A 2II4A 1EAFA 2I9DA 2H3WA 2E1UA 2II5A 5FALA 1NOCB 3CLAA 2FY2A 2XR7A 1XL7A 2DEBA 2RCUA 5KJTA 1NDBA 4G0BA 4EYWA 2H3UA 1EADA 1DPDA 2E1VA 4KECA 1XMCA 5KJVA 1XL8A 2H4TA 3B30A 5KJSA 1EAAA 1Q23A 2JGPA 2FW3A 2ZBAA 2BGHA 1SCZA 2E1TA 3FP0A 1T1UA 2FY4A 1C4TA 5KJUA 2IHWA 1NDFA 4G22A 1T7OA 1S5OA 2H3PA 3U9FA 3B2SA 5T3EA 3FOTA 3L60A 2RKVA 1T7NA 1QCAA 4HVMA 4N72A 3U9BA 3MAEA 1Q9JA 1DPBA 4CLAA 2RKTA 5DUAA 5KJWA 2FYOA 5FANA 1EABA 1L5AA 1Q6XA 4G2MA 1NDIA 2FY5A 4KE4A 2VSQA 1NM8A 1CIAA 2FY3A 1XMDA 2CLAA 1E2OA 4EPHA 1DPCA 1EACA 1PD5A 2XHGA 1CLAA 2II3A 1EAEA
chains in the Genus database with same CATH topology
1XMCA 5DU9A 4JN3A 4JN5A 4KE4A 5KJVA 1XL8A 2II4A 2RKVA 2VSQA 3B30A 1EAFA 1EAAA 1QCAA 2I9DA 5KJSA 1CIAA 4HVMA 1Q23A 1XMDA 2CLAA 2JGPA 4N72A 2E1UA 1E2OA 2II5A 2ZBAA 2BGHA 3U9BA 1SCZA 1DPCA 2E1TA 3FP0A 3MAEA 1EACA 1NOCB 1C4TA 1Q9JA 1PD5A 3CLAA 1DPBA 5FALA 2XHGA 2XR7A 5KJUA 1XL7A 2IHWA 1CLAA 4CLAA 4G22A 5KJTA 2RKTA 5DUAA 5KJWA 5FANA 1EABA 1L5AA 4G0BA 3U9FA 2II3A 3B2SA 5T3EA 4G2MA 3FOTA 1EADA 1EAEA 3L60A 1DPDA 2E1VA 4KECA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XMC A;  5DU9 A;  4JN3 A;  4JN5 A;  4KE4 A;  5KJV A;  1XL8 A;  2II4 A;  2RKV A;  2VSQ A;  3B30 A;  1EAF A;  1EAA A;  1QCA A;  2I9D A;  5KJS A;  1CIA A;  4HVM A;  1Q23 A;  1XMD A;  2CLA A;  2JGP A;  4N72 A;  2E1U A;  1E2O A;  2II5 A;  2ZBA A;  2BGH A;  3U9B A;  1SCZ A;  1DPC A;  2E1T A;  3FP0 A;  3MAE A;  1EAC A;  1NOC B;  1C4T A;  1Q9J A;  1PD5 A;  3CLA A;  1DPB A;  5FAL A;  2XHG A;  2XR7 A;  5KJU A;  1XL7 A;  2IHW A;  1CLA A;  4CLA A;  4G22 A;  5KJT A;  2RKT A;  5DUA A;  5KJW A;  5FAN A;  1EAB A;  1L5A A;  4G0B A;  3U9F A;  2II3 A;  3B2S A;  5T3E A;  4G2M A;  3FOT A;  1EAD A;  1EAE A;  3L60 A;  1DPD A;  2E1V A;  4KEC A; 
#chains in the Genus database with same CATH topology
 5DU9 A;  4JN3 A;  1T7Q A;  4JN5 A;  4EP9 A;  2II4 A;  1EAF A;  2I9D A;  2H3W A;  2E1U A;  2II5 A;  5FAL A;  1NOC B;  3CLA A;  2FY2 A;  2XR7 A;  1XL7 A;  2DEB A;  2RCU A;  5KJT A;  1NDB A;  4G0B A;  4EYW A;  2H3U A;  1EAD A;  1DPD A;  2E1V A;  4KEC A;  1XMC A;  5KJV A;  1XL8 A;  2H4T A;  3B30 A;  5KJS A;  1EAA A;  1Q23 A;  2JGP A;  2FW3 A;  2ZBA A;  2BGH A;  1SCZ A;  2E1T A;  3FP0 A;  1T1U A;  2FY4 A;  1C4T A;  5KJU A;  2IHW A;  1NDF A;  4G22 A;  1T7O A;  1S5O A;  2H3P A;  3U9F A;  3B2S A;  5T3E A;  3FOT A;  3L60 A;  2RKV A;  1T7N A;  1QCA A;  4HVM A;  4N72 A;  3U9B A;  3MAE A;  1Q9J A;  1DPB A;  4CLA A;  2RKT A;  5DUA A;  5KJW A;  2FYO A;  5FAN A;  1EAB A;  1L5A A;  1Q6X A;  4G2M A;  1NDI A;  2FY5 A;  4KE4 A;  2VSQ A;  1NM8 A;  1CIA A;  2FY3 A;  1XMD A;  2CLA A;  1E2O A;  4EPH A;  1DPC A;  1EAC A;  1PD5 A;  2XHG A;  1CLA A;  2II3 A;  1EAE A; 
#chains in the Genus database with same CATH homology
 1XMC A;  5DU9 A;  4JN3 A;  4JN5 A;  4KE4 A;  5KJV A;  1XL8 A;  2II4 A;  2RKV A;  2VSQ A;  3B30 A;  1EAF A;  1EAA A;  1QCA A;  2I9D A;  5KJS A;  1CIA A;  4HVM A;  1Q23 A;  1XMD A;  2CLA A;  2JGP A;  4N72 A;  2E1U A;  1E2O A;  2II5 A;  2ZBA A;  2BGH A;  3U9B A;  1SCZ A;  1DPC A;  2E1T A;  3FP0 A;  3MAE A;  1EAC A;  1NOC B;  1C4T A;  1Q9J A;  1PD5 A;  3CLA A;  1DPB A;  5FAL A;  2XHG A;  2XR7 A;  5KJU A;  1XL7 A;  2IHW A;  1CLA A;  4CLA A;  4G22 A;  5KJT A;  2RKT A;  5DUA A;  5KJW A;  5FAN A;  1EAB A;  1L5A A;  4G0B A;  3U9F A;  2II3 A;  3B2S A;  5T3E A;  4G2M A;  3FOT A;  1EAD A;  1EAE A;  3L60 A;  1DPD A;  2E1V A;  4KEC A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...