2ERHA

Crystal structure of the e7_g/im7_g complex; a designed interface between the colicin e7 dnase and the im7 immunity protein
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
87
structure length
87
Chain Sequence
MELKNSISDYTEAEFVQLLKEIEKENVAATDDVLYVLLEHFVKITEHPDGQDLIYYPSDNRDDSPEGIVKEIKEWRAANGKPGFKQG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Computational Design of a New Hydrogen Bond Network and at Least a 300-fold Specificity Switch at a Protein-Protein Interface.
pubmed doi rcsb
molecule keywords Colicin E7 immunity protein
molecule tags Hydrolase/hydrolase inhibitor
source organism Escherichia coli
total genus 34
structure length 87
sequence length 87
ec nomenclature
pdb deposition date 2005-10-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01320 Colicin_Pyocin Colicin immunity protein / pyocin immunity protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1200.20 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A Colicin E immunity protein 2erhA00
1IMPA 1ZNVA 3GJNA 1UNKA 2VLQA 2K0DX 1GXHA 1FR2A 4UHPB 1CEIA 2VLOA 4F37A 1GXGA 4QKOA 1UJZA 2VLPA 1E0HA 2GZJA 1AYIA 2GZFA 1BXIA 2K5XA 3GKLC 1MZ8A 3U43A 7CEIA 2NO8A 5EW5E 2GZIA 2GZEA 1IMQA 2WPTA 2JBGA 2GYKA 2JAZA 2VLNA 1EMVA 2GZGA 2ERHA 2JB0A
chains in the Genus database with same CATH superfamily
4PH0A 1L0HA 3EJDA 1QVGO 4PXHB 2KG8A 2AF8A 3I56P 2M8PA 2EFJA 5I4TG 2FHSC 2GZEA 2L9FA 2KGCA 2KR5A 2JYGA 2M5RA 2P9XA 2MR8A 4WYMA 2KOPA 4U0BA 3CE7A 1M6NA 3EJEA 4F37A 2KG9A 1UJZA 5HVCA 1K8AQ 2FVEA 2KWLA 1K73Q 2PEKA 1YI2P 3GZMA 2WPTA 2LOLA 3WBHA 1KC8Q 2VLNA 3CMAP 2FACA 4U0FA 3GJNA 2KGAA 2N5IA 4HKGA 2LL8A 2VLPA 1DNYA 2K5XA 2KOQA 1OR5A 1MZ8A 2L6EA 1VQ7P 2QA4P 3CCVP 1K30A 1IUQA 3CC7P 4QNBA 2BUOA 2JO0A 2LMLA 2QEXP 4XFYA 2CG5B 4COCA 5HGMA 2JU2A 1W2BO 5F2KA 2KOOA 2ERHA 3NTEA 2JQ4A 5BS1A 4MRTC 2DNWA 4M0IA 3CC4P 2K0DX 1FR2A 1RO0A 1GXGA 2GDYA 5HGNA 1BXIA 2LPKA 5F2OA 2MY5A 3CCRP 2EHTA 3DPHA 5HV8A 3G1IA 1VQLP 1M74A 1ACPA 2GZGA 1YITP 3CCLP 2L0QA 2VLQA 2KOSA 1CEIA 3CXCO 3DS1A 3CC2P 4BPHA 3G4SP 3OW2O 3CCQP 3DS2A 3E2DA 4U0DA 1M6EX 2OTLP 4XFXA 5HGOA 2XXMA 2CQ8A 2XZ0D 1ZMBA 4U0EA 2JYLA 2M8LA 3G29A 1F80D 1A43A 1KQSO 3CMEP 3H47A 1EIAA 3CPWO 2VLOA 2PEOA 2K92A 5HGLA 1E0HA 2FQ0A 1AUMA 2E1MA 3U43A 2PENA 2AFDA 3HYBA 1VQKP 1NJIQ 3DS3A 1UNKA 1X3OA 1M90Q 3VRLC 2KORA 1QRJA 2FADA 2N5HA 1AYIA 2GZFA 2K0YA 1YIJP 2NO8A 2LF4A 3P05A 1GPJA 2OTJP 2PEJA 2JU1A 3G71P 5KP8B 4NEOA 3Q20A 4U0AA 3G6EP 1RO2A 2DGYA 2XT1A 2XZ1C 2EIAA 1HQBA 2GDXA 1YJNP 1VQNP 1L0IA 4U0CA 1YJ9P 3B5IA 2CWOA 2X2BA 2JBGA 2M8NA 1KD1Q 1HY8A 2N50A 2OARA 1K9MQ 1YJWP 4XFZA 1ZNVA 2CNRA 1VQ4P 3G1GA 2QNWA 5JPAA 1VQPP 1GXHA 2K94A 2CGQA 3HZQA 3DS0A 3H4EA 2VSQA 2AVAA 2Z45A 4H2WC 3NY7B 2GYKA 1T8KA 4H2YC 1DV5A 2KG6A 2L4BA 3CCMP 4BPGA 2GDWA 5EW5E 2JB0A 5F2NA 2FQ2A 4GR6A 1VQ8P 2KGEA 2N6YA 3DS4A 4PWVB 1N8RQ 1QVFO 4UHPB 1Q86Q 1Q82Q 3EJBA 4XROA 1KLPA 4XRQA 2EHSA 4IPYA 2JAZA 3I55P 4GR2A 3CCEP 1IMPA 2N6ZA 3MGEA 4IZ6A 2LIUA 2L22A 2FQ1A 3G28A 1RNIA 3G21A 1S72P 1VKUA 2XV6A 4R0MA 1E6JP 2GZJA 2KODA 1VQOP 5KP7B 2LTEA 4COPA 3RG6C 2PEQA 2FVAA 1A8OA 2K2QA 2MD9A 5KP6B 2PNGA 4CA3A 2Z46A 1AF8A 2PEIA 1EMVA 2ONTA 1Q81Q 3CD6P 2MVVA 2K0XA 1Z6MA 3LRYA 3CCJP 3CCSP 1VQ9P 3CCUP 1D1DA 1VHNA 2JGPA 2K93A 5CZDB 1IMQA 1YHQP 1BAJA 1JJ2O 3GZLA 1EOQA 2ROQA 5DCKA 2BHVA 3G0VA 5BS2A 4DG9A 2AFEA 2Z44A 2MF4A 1NQ4A 4QKOA 3G26A 4H2XC 5EJDA 2PY8A 2FAEA 1VQ5P 3B4QA 2KW2A 4PH1A 3DS5A 3LMOA 2N98A 2FVFA 3DTJA 2EG5A 4BPFA 3RG2A 1Q7YQ 2MVUA 3GKLC 2PEMA 7CEIA 1VQ6P 2GZIA 3M1MA 1M1KQ 1VQMP 2MR7A 2KGDA 2LIWA 3H0DA 2LKIA
chains in the Genus database with same CATH topology
1IMPA 1ZNVA 3GJNA 1UNKA 2VLQA 2K0DX 1GXHA 1FR2A 4UHPB 1CEIA 2VLOA 4F37A 1GXGA 4QKOA 1UJZA 2VLPA 1E0HA 2GZJA 1AYIA 2GZFA 1BXIA 2K5XA 3GKLC 1MZ8A 3U43A 7CEIA 2NO8A 5EW5E 2GZIA 2GZEA 1IMQA 2WPTA 2JBGA 2GYKA 2JAZA 2VLNA 1EMVA 2GZGA 2ERHA 2JB0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1IMP A;  1ZNV A;  3GJN A;  1UNK A;  2VLQ A;  2K0D X;  1GXH A;  1FR2 A;  4UHP B;  1CEI A;  2VLO A;  4F37 A;  1GXG A;  4QKO A;  1UJZ A;  2VLP A;  1E0H A;  2GZJ A;  1AYI A;  2GZF A;  1BXI A;  2K5X A;  3GKL C;  1MZ8 A;  3U43 A;  7CEI A;  2NO8 A;  5EW5 E;  2GZI A;  2GZE A;  1IMQ A;  2WPT A;  2JBG A;  2GYK A;  2JAZ A;  2VLN A;  1EMV A;  2GZG A;  2ERH A;  2JB0 A; 
#chains in the Genus database with same CATH topology
 4PH0 A;  1L0H A;  3EJD A;  1QVG O;  4PXH B;  2KG8 A;  2AF8 A;  3I56 P;  2M8P A;  2EFJ A;  5I4T G;  2FHS C;  2GZE A;  2L9F A;  2KGC A;  2KR5 A;  2JYG A;  2M5R A;  2P9X A;  2MR8 A;  4WYM A;  2KOP A;  4U0B A;  3CE7 A;  1M6N A;  3EJE A;  4F37 A;  2KG9 A;  1UJZ A;  5HVC A;  1K8A Q;  2FVE A;  2KWL A;  1K73 Q;  2PEK A;  1YI2 P;  3GZM A;  2WPT A;  2LOL A;  3WBH A;  1KC8 Q;  2VLN A;  3CMA P;  2FAC A;  4U0F A;  3GJN A;  2KGA A;  2N5I A;  4HKG A;  2LL8 A;  2VLP A;  1DNY A;  2K5X A;  2KOQ A;  1OR5 A;  1MZ8 A;  2L6E A;  1VQ7 P;  2QA4 P;  3CCV P;  1K30 A;  1IUQ A;  3CC7 P;  4QNB A;  2BUO A;  2JO0 A;  2LML A;  2QEX P;  4XFY A;  2CG5 B;  4COC A;  5HGM A;  2JU2 A;  1W2B O;  5F2K A;  2KOO A;  2ERH A;  3NTE A;  2JQ4 A;  5BS1 A;  4MRT C;  2DNW A;  4M0I A;  3CC4 P;  2K0D X;  1FR2 A;  1RO0 A;  1GXG A;  2GDY A;  5HGN A;  1BXI A;  2LPK A;  5F2O A;  2MY5 A;  3CCR P;  2EHT A;  3DPH A;  5HV8 A;  3G1I A;  1VQL P;  1M74 A;  1ACP A;  2GZG A;  1YIT P;  3CCL P;  2L0Q A;  2VLQ A;  2KOS A;  1CEI A;  3CXC O;  3DS1 A;  3CC2 P;  4BPH A;  3G4S P;  3OW2 O;  3CCQ P;  3DS2 A;  3E2D A;  4U0D A;  1M6E X;  2OTL P;  4XFX A;  5HGO A;  2XXM A;  2CQ8 A;  2XZ0 D;  1ZMB A;  4U0E A;  2JYL A;  2M8L A;  3G29 A;  1F80 D;  1A43 A;  1KQS O;  3CME P;  3H47 A;  1EIA A;  3CPW O;  2VLO A;  2PEO A;  2K92 A;  5HGL A;  1E0H A;  2FQ0 A;  1AUM A;  2E1M A;  3U43 A;  2PEN A;  2AFD A;  3HYB A;  1VQK P;  1NJI Q;  3DS3 A;  1UNK A;  1X3O A;  1M90 Q;  3VRL C;  2KOR A;  1QRJ A;  2FAD A;  2N5H A;  1AYI A;  2GZF A;  2K0Y A;  1YIJ P;  2NO8 A;  2LF4 A;  3P05 A;  1GPJ A;  2OTJ P;  2PEJ A;  2JU1 A;  3G71 P;  5KP8 B;  4NEO A;  3Q20 A;  4U0A A;  3G6E P;  1RO2 A;  2DGY A;  2XT1 A;  2XZ1 C;  2EIA A;  1HQB A;  2GDX A;  1YJN P;  1VQN P;  1L0I A;  4U0C A;  1YJ9 P;  3B5I A;  2CWO A;  2X2B A;  2JBG A;  2M8N A;  1KD1 Q;  1HY8 A;  2N50 A;  2OAR A;  1K9M Q;  1YJW P;  4XFZ A;  1ZNV A;  2CNR A;  1VQ4 P;  3G1G A;  2QNW A;  5JPA A;  1VQP P;  1GXH A;  2K94 A;  2CGQ A;  3HZQ A;  3DS0 A;  3H4E A;  2VSQ A;  2AVA A;  2Z45 A;  4H2W C;  3NY7 B;  2GYK A;  1T8K A;  4H2Y C;  1DV5 A;  2KG6 A;  2L4B A;  3CCM P;  4BPG A;  2GDW A;  5EW5 E;  2JB0 A;  5F2N A;  2FQ2 A;  4GR6 A;  1VQ8 P;  2KGE A;  2N6Y A;  3DS4 A;  4PWV B;  1N8R Q;  1QVF O;  4UHP B;  1Q86 Q;  1Q82 Q;  3EJB A;  4XRO A;  1KLP A;  4XRQ A;  2EHS A;  4IPY A;  2JAZ A;  3I55 P;  4GR2 A;  3CCE P;  1IMP A;  2N6Z A;  3MGE A;  4IZ6 A;  2LIU A;  2L22 A;  2FQ1 A;  3G28 A;  1RNI A;  3G21 A;  1S72 P;  1VKU A;  2XV6 A;  4R0M A;  1E6J P;  2GZJ A;  2KOD A;  1VQO P;  5KP7 B;  2LTE A;  4COP A;  3RG6 C;  2PEQ A;  2FVA A;  1A8O A;  2K2Q A;  2MD9 A;  5KP6 B;  2PNG A;  4CA3 A;  2Z46 A;  1AF8 A;  2PEI A;  1EMV A;  2ONT A;  1Q81 Q;  3CD6 P;  2MVV A;  2K0X A;  1Z6M A;  3LRY A;  3CCJ P;  3CCS P;  1VQ9 P;  3CCU P;  1D1D A;  1VHN A;  2JGP A;  2K93 A;  5CZD B;  1IMQ A;  1YHQ P;  1BAJ A;  1JJ2 O;  3GZL A;  1EOQ A;  2ROQ A;  5DCK A;  2BHV A;  3G0V A;  5BS2 A;  4DG9 A;  2AFE A;  2Z44 A;  2MF4 A;  1NQ4 A;  4QKO A;  3G26 A;  4H2X C;  5EJD A;  2PY8 A;  2FAE A;  1VQ5 P;  3B4Q A;  2KW2 A;  4PH1 A;  3DS5 A;  3LMO A;  2N98 A;  2FVF A;  3DTJ A;  2EG5 A;  4BPF A;  3RG2 A;  1Q7Y Q;  2MVU A;  3GKL C;  2PEM A;  7CEI A;  1VQ6 P;  2GZI A;  3M1M A;  1M1K Q;  1VQM P;  2MR7 A;  2KGD A;  2LIW A;  3H0D A;  2LKI A; 
#chains in the Genus database with same CATH homology
 1IMP A;  1ZNV A;  3GJN A;  1UNK A;  2VLQ A;  2K0D X;  1GXH A;  1FR2 A;  4UHP B;  1CEI A;  2VLO A;  4F37 A;  1GXG A;  4QKO A;  1UJZ A;  2VLP A;  1E0H A;  2GZJ A;  1AYI A;  2GZF A;  1BXI A;  2K5X A;  3GKL C;  1MZ8 A;  3U43 A;  7CEI A;  2NO8 A;  5EW5 E;  2GZI A;  2GZE A;  1IMQ A;  2WPT A;  2JBG A;  2GYK A;  2JAZ A;  2VLN A;  1EMV A;  2GZG A;  2ERH A;  2JB0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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