2EVCA

Crystal structure of e. coli. methionine amino peptidase in complex with 5-(2-(trifluoromethyl)phenyl)furan-2-carboxylic acid
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
259
structure length
259
Chain Sequence
SIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural analysis of metalloform-selective inhibition of methionine aminopeptidase.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
molecule tags Hydrolase
source organism Escherichia coli
total genus 85
structure length 259
sequence length 259
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-10-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2evcA00
4IPAA 1WKMA 2B3LA 3IU9A 4U73A 1KP0A 4B28A 1Y1NA 2V3XA 3CB5A 2EA2A 5JHUA 5FCFA 1W7VA 3TAVA 2GTXA 4U76A 1C24A 2MATA 4RGZ1 4A6WA 2P99A 3CTZA 1XGNA 2B3HA 3CB6A 2Q8KA 2ADUA 4IU6A 4U6CA 2GU4A 4FUKA 2Q95A 1W2MA 1JAWA 3L7GA 4U75A 1B59A 2GA2A 1XGSA 1R5HA 1R58A 2BWTA 2GU6A 4U69A 2EVCA 5CNXA 2Q94A 2GG8A 4QR8A 2BWYA 2GG0A 2DFIA 4FLJA 4FO8A 1PV9A 1WL6A 2Q92A 4U1BA 1YJ3A 1CHMA 3TB5A 2V3ZA 4S00A 3Q6DA 1XGOA 4PNCA 2GZ5A 2GG9A 1A16A 1XNZA 4FLKA 2EA4A 3IU7A 1C27A 4OOKA 2Q96A 2BWVA 4HXXA 4U6ZA 4ZNGA 4RZZA 5E5BA 4S2RP 1M35A 1WL9A 1YVMA 2EVOA 5CDLA 3PKCA 4U6JA 2P98A 4FO7A 4IKTA 4U6WA 4RZYA 3BITA 3BIQA 4A6VA 4S2TP 4FLLA 4PV4A 5CLSA 1BOAA 1KQ0A 3D27A 4ZWUA 2BHAA 2BWWA 4U71A 1XGMA 1O0XA 5JFRA 2NQ7A 3MATA 2HOWA 3FMRA 1WBQA 1R5GA 2P9AA 5CE6A 3L24A 1YW7A 4JUQA 2OAZA 4KM3A 2GG5A 2BH3A 3BIPA 2BWXA 1C23A 1C21A 1MATA 1WY2A 1QZYA 3MR1A 4IKRA 4MATA 1B6AA 3IG4A 1QXWA 2IW2A 3PKDA 5D6EA 3IU8A 4IKSA 4R60A 2OKNA 4Z7MA 5FCHA 2BWUA 2V3YA 4ZWPA 5CDVA 4IF7A 5CIKA 2BHDA 4FKCA 2NQ6A 1YW8A 2GG3A 2B3KA 4ZWOA 5JI6A 2BB7A 2Q93A 1C22A 1WN1A 2V6CA 5D6FA 1N51A 2GGBA 1YW9A 4IDYA 5CDEA 4IECA 3MX6A 3RORA 1KQ9A 2G6PA 3S6BA 4FLIA 2GGCA 2GG2A 4U70A 2BHBA 3PKAA 1QXYA 3FMQA 3PKBA 2BHCA 3RVAA 1WLRA 2ZSGA 3FM3A 4EGEA 1QXZA 2GG7A 2GU5A 3PKEA 4U6EA 4S01A 2BN7A 2BWSA 1BN5A 4IKUA 2GU7A 2EVMA
chains in the Genus database with same CATH superfamily
4IPAA 1WKMA 2B3LA 3IU9A 4U73A 1KP0A 4B28A 1Y1NA 2V3XA 3CB5A 2EA2A 5JHUA 5FCFA 1W7VA 3TAVA 2GTXA 4U76A 1C24A 2MATA 4RGZ1 4A6WA 2P99A 3CTZA 1XGNA 2B3HA 3CB6A 2Q8KA 2ADUA 4IU6A 4U6CA 2GU4A 4FUKA 2Q95A 1W2MA 1JAWA 3L7GA 4U75A 1B59A 2GA2A 1XGSA 1R5HA 1R58A 2BWTA 2GU6A 4U69A 2EVCA 5CNXA 2Q94A 2GG8A 4QR8A 2BWYA 2GG0A 2DFIA 4FLJA 4FO8A 1PV9A 1WL6A 2Q92A 4U1BA 1YJ3A 1CHMA 3TB5A 2V3ZA 4S00A 3Q6DA 1XGOA 4PNCA 2GZ5A 2GG9A 1A16A 1XNZA 4FLKA 2EA4A 3IU7A 1C27A 4OOKA 2Q96A 2BWVA 4HXXA 4U6ZA 4ZNGA 4RZZA 5E5BA 4S2RP 1M35A 1WL9A 1YVMA 2EVOA 5CDLA 3PKCA 4U6JA 2P98A 4FO7A 4IKTA 4U6WA 4RZYA 3BITA 3BIQA 4A6VA 4S2TP 4FLLA 4PV4A 5CLSA 1BOAA 1KQ0A 3D27A 4ZWUA 2BHAA 2BWWA 4U71A 1XGMA 1O0XA 5JFRA 2NQ7A 3MATA 2HOWA 3FMRA 1WBQA 1R5GA 2P9AA 5CE6A 3L24A 1YW7A 4JUQA 2OAZA 4KM3A 2GG5A 2BH3A 3BIPA 2BWXA 1C23A 1C21A 1MATA 1WY2A 1QZYA 3MR1A 4IKRA 4MATA 1B6AA 3IG4A 1QXWA 2IW2A 3PKDA 5D6EA 3IU8A 4IKSA 4R60A 2OKNA 4Z7MA 5FCHA 2BWUA 2V3YA 4ZWPA 5CDVA 4IF7A 5CIKA 2BHDA 4FKCA 2NQ6A 1YW8A 2GG3A 2B3KA 4ZWOA 5JI6A 2BB7A 2Q93A 1C22A 1WN1A 2V6CA 5D6FA 1N51A 2GGBA 1YW9A 4IDYA 5CDEA 4IECA 3MX6A 3RORA 1KQ9A 2G6PA 3S6BA 4FLIA 2GGCA 2GG2A 4U70A 2BHBA 3PKAA 1QXYA 3FMQA 3PKBA 2BHCA 3RVAA 1WLRA 2ZSGA 3FM3A 4EGEA 1QXZA 2GG7A 2GU5A 3PKEA 4U6EA 4S01A 2BN7A 2BWSA 1BN5A 4IKUA 2GU7A 2EVMA
chains in the Genus database with same CATH topology
4IPAA 1WKMA 2B3LA 3IU9A 4U73A 1KP0A 4B28A 1Y1NA 2V3XA 3CB5A 2EA2A 5JHUA 5FCFA 1W7VA 3TAVA 2GTXA 4U76A 1C24A 2MATA 4RGZ1 4A6WA 2P99A 3CTZA 1XGNA 2B3HA 3CB6A 2Q8KA 2ADUA 4IU6A 4U6CA 2GU4A 4FUKA 2Q95A 1W2MA 1JAWA 3L7GA 4U75A 1B59A 2GA2A 1XGSA 1R5HA 1R58A 2BWTA 2GU6A 4U69A 2EVCA 5CNXA 2Q94A 2GG8A 4QR8A 2BWYA 2GG0A 2DFIA 4FLJA 4FO8A 1PV9A 1WL6A 2Q92A 4U1BA 1YJ3A 1CHMA 3TB5A 2V3ZA 4S00A 3Q6DA 1XGOA 4PNCA 2GZ5A 2GG9A 1A16A 1XNZA 4FLKA 2EA4A 3IU7A 1C27A 4OOKA 2Q96A 2BWVA 4HXXA 4U6ZA 4ZNGA 4RZZA 5E5BA 4S2RP 1M35A 1WL9A 1YVMA 2EVOA 5CDLA 3PKCA 4U6JA 2P98A 4FO7A 4IKTA 4U6WA 4RZYA 3BITA 3BIQA 4A6VA 4S2TP 4FLLA 4PV4A 5CLSA 1BOAA 1KQ0A 3D27A 4ZWUA 2BHAA 2BWWA 4U71A 1XGMA 1O0XA 5JFRA 2NQ7A 3MATA 2HOWA 3FMRA 1WBQA 1R5GA 2P9AA 5CE6A 3L24A 1YW7A 4JUQA 2OAZA 4KM3A 2GG5A 2BH3A 3BIPA 2BWXA 1C23A 1C21A 1MATA 1WY2A 1QZYA 3MR1A 4IKRA 4MATA 1B6AA 3IG4A 1QXWA 2IW2A 3PKDA 5D6EA 3IU8A 4IKSA 4R60A 2OKNA 4Z7MA 5FCHA 2BWUA 2V3YA 4ZWPA 5CDVA 4IF7A 5CIKA 2BHDA 4FKCA 2NQ6A 1YW8A 2GG3A 2B3KA 4ZWOA 5JI6A 2BB7A 2Q93A 1C22A 1WN1A 2V6CA 5D6FA 1N51A 2GGBA 1YW9A 4IDYA 5CDEA 4IECA 3MX6A 3RORA 1KQ9A 2G6PA 3S6BA 4FLIA 2GGCA 2GG2A 4U70A 2BHBA 3PKAA 1QXYA 3FMQA 3PKBA 2BHCA 3RVAA 1WLRA 2ZSGA 3FM3A 4EGEA 1QXZA 2GG7A 2GU5A 3PKEA 4U6EA 4S01A 2BN7A 2BWSA 1BN5A 4IKUA 2GU7A 2EVMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IPA A;  1WKM A;  2B3L A;  3IU9 A;  4U73 A;  1KP0 A;  4B28 A;  1Y1N A;  2V3X A;  3CB5 A;  2EA2 A;  5JHU A;  5FCF A;  1W7V A;  3TAV A;  2GTX A;  4U76 A;  1C24 A;  2MAT A;  4RGZ 1;  4A6W A;  2P99 A;  3CTZ A;  1XGN A;  2B3H A;  3CB6 A;  2Q8K A;  2ADU A;  4IU6 A;  4U6C A;  2GU4 A;  4FUK A;  2Q95 A;  1W2M A;  1JAW A;  3L7G A;  4U75 A;  1B59 A;  2GA2 A;  1XGS A;  1R5H A;  1R58 A;  2BWT A;  2GU6 A;  4U69 A;  2EVC A;  5CNX A;  2Q94 A;  2GG8 A;  4QR8 A;  2BWY A;  2GG0 A;  2DFI A;  4FLJ A;  4FO8 A;  1PV9 A;  1WL6 A;  2Q92 A;  4U1B A;  1YJ3 A;  1CHM A;  3TB5 A;  2V3Z A;  4S00 A;  3Q6D A;  1XGO A;  4PNC A;  2GZ5 A;  2GG9 A;  1A16 A;  1XNZ A;  4FLK A;  2EA4 A;  3IU7 A;  1C27 A;  4OOK A;  2Q96 A;  2BWV A;  4HXX A;  4U6Z A;  4ZNG A;  4RZZ A;  5E5B A;  4S2R P;  1M35 A;  1WL9 A;  1YVM A;  2EVO A;  5CDL A;  3PKC A;  4U6J A;  2P98 A;  4FO7 A;  4IKT A;  4U6W A;  4RZY A;  3BIT A;  3BIQ A;  4A6V A;  4S2T P;  4FLL A;  4PV4 A;  5CLS A;  1BOA A;  1KQ0 A;  3D27 A;  4ZWU A;  2BHA A;  2BWW A;  4U71 A;  1XGM A;  1O0X A;  5JFR A;  2NQ7 A;  3MAT A;  2HOW A;  3FMR A;  1WBQ A;  1R5G A;  2P9A A;  5CE6 A;  3L24 A;  1YW7 A;  4JUQ A;  2OAZ A;  4KM3 A;  2GG5 A;  2BH3 A;  3BIP A;  2BWX A;  1C23 A;  1C21 A;  1MAT A;  1WY2 A;  1QZY A;  3MR1 A;  4IKR A;  4MAT A;  1B6A A;  3IG4 A;  1QXW A;  2IW2 A;  3PKD A;  5D6E A;  3IU8 A;  4IKS A;  4R60 A;  2OKN A;  4Z7M A;  5FCH A;  2BWU A;  2V3Y A;  4ZWP A;  5CDV A;  4IF7 A;  5CIK A;  2BHD A;  4FKC A;  2NQ6 A;  1YW8 A;  2GG3 A;  2B3K A;  4ZWO A;  5JI6 A;  2BB7 A;  2Q93 A;  1C22 A;  1WN1 A;  2V6C A;  5D6F A;  1N51 A;  2GGB A;  1YW9 A;  4IDY A;  5CDE A;  4IEC A;  3MX6 A;  3ROR A;  1KQ9 A;  2G6P A;  3S6B A;  4FLI A;  2GGC A;  2GG2 A;  4U70 A;  2BHB A;  3PKA A;  1QXY A;  3FMQ A;  3PKB A;  2BHC A;  3RVA A;  1WLR A;  2ZSG A;  3FM3 A;  4EGE A;  1QXZ A;  2GG7 A;  2GU5 A;  3PKE A;  4U6E A;  4S01 A;  2BN7 A;  2BWS A;  1BN5 A;  4IKU A;  2GU7 A;  2EVM A; 
#chains in the Genus database with same CATH topology
 4IPA A;  1WKM A;  2B3L A;  3IU9 A;  4U73 A;  1KP0 A;  4B28 A;  1Y1N A;  2V3X A;  3CB5 A;  2EA2 A;  5JHU A;  5FCF A;  1W7V A;  3TAV A;  2GTX A;  4U76 A;  1C24 A;  2MAT A;  4RGZ 1;  4A6W A;  2P99 A;  3CTZ A;  1XGN A;  2B3H A;  3CB6 A;  2Q8K A;  2ADU A;  4IU6 A;  4U6C A;  2GU4 A;  4FUK A;  2Q95 A;  1W2M A;  1JAW A;  3L7G A;  4U75 A;  1B59 A;  2GA2 A;  1XGS A;  1R5H A;  1R58 A;  2BWT A;  2GU6 A;  4U69 A;  2EVC A;  5CNX A;  2Q94 A;  2GG8 A;  4QR8 A;  2BWY A;  2GG0 A;  2DFI A;  4FLJ A;  4FO8 A;  1PV9 A;  1WL6 A;  2Q92 A;  4U1B A;  1YJ3 A;  1CHM A;  3TB5 A;  2V3Z A;  4S00 A;  3Q6D A;  1XGO A;  4PNC A;  2GZ5 A;  2GG9 A;  1A16 A;  1XNZ A;  4FLK A;  2EA4 A;  3IU7 A;  1C27 A;  4OOK A;  2Q96 A;  2BWV A;  4HXX A;  4U6Z A;  4ZNG A;  4RZZ A;  5E5B A;  4S2R P;  1M35 A;  1WL9 A;  1YVM A;  2EVO A;  5CDL A;  3PKC A;  4U6J A;  2P98 A;  4FO7 A;  4IKT A;  4U6W A;  4RZY A;  3BIT A;  3BIQ A;  4A6V A;  4S2T P;  4FLL A;  4PV4 A;  5CLS A;  1BOA A;  1KQ0 A;  3D27 A;  4ZWU A;  2BHA A;  2BWW A;  4U71 A;  1XGM A;  1O0X A;  5JFR A;  2NQ7 A;  3MAT A;  2HOW A;  3FMR A;  1WBQ A;  1R5G A;  2P9A A;  5CE6 A;  3L24 A;  1YW7 A;  4JUQ A;  2OAZ A;  4KM3 A;  2GG5 A;  2BH3 A;  3BIP A;  2BWX A;  1C23 A;  1C21 A;  1MAT A;  1WY2 A;  1QZY A;  3MR1 A;  4IKR A;  4MAT A;  1B6A A;  3IG4 A;  1QXW A;  2IW2 A;  3PKD A;  5D6E A;  3IU8 A;  4IKS A;  4R60 A;  2OKN A;  4Z7M A;  5FCH A;  2BWU A;  2V3Y A;  4ZWP A;  5CDV A;  4IF7 A;  5CIK A;  2BHD A;  4FKC A;  2NQ6 A;  1YW8 A;  2GG3 A;  2B3K A;  4ZWO A;  5JI6 A;  2BB7 A;  2Q93 A;  1C22 A;  1WN1 A;  2V6C A;  5D6F A;  1N51 A;  2GGB A;  1YW9 A;  4IDY A;  5CDE A;  4IEC A;  3MX6 A;  3ROR A;  1KQ9 A;  2G6P A;  3S6B A;  4FLI A;  2GGC A;  2GG2 A;  4U70 A;  2BHB A;  3PKA A;  1QXY A;  3FMQ A;  3PKB A;  2BHC A;  3RVA A;  1WLR A;  2ZSG A;  3FM3 A;  4EGE A;  1QXZ A;  2GG7 A;  2GU5 A;  3PKE A;  4U6E A;  4S01 A;  2BN7 A;  2BWS A;  1BN5 A;  4IKU A;  2GU7 A;  2EVM A; 
#chains in the Genus database with same CATH homology
 4IPA A;  1WKM A;  2B3L A;  3IU9 A;  4U73 A;  1KP0 A;  4B28 A;  1Y1N A;  2V3X A;  3CB5 A;  2EA2 A;  5JHU A;  5FCF A;  1W7V A;  3TAV A;  2GTX A;  4U76 A;  1C24 A;  2MAT A;  4RGZ 1;  4A6W A;  2P99 A;  3CTZ A;  1XGN A;  2B3H A;  3CB6 A;  2Q8K A;  2ADU A;  4IU6 A;  4U6C A;  2GU4 A;  4FUK A;  2Q95 A;  1W2M A;  1JAW A;  3L7G A;  4U75 A;  1B59 A;  2GA2 A;  1XGS A;  1R5H A;  1R58 A;  2BWT A;  2GU6 A;  4U69 A;  2EVC A;  5CNX A;  2Q94 A;  2GG8 A;  4QR8 A;  2BWY A;  2GG0 A;  2DFI A;  4FLJ A;  4FO8 A;  1PV9 A;  1WL6 A;  2Q92 A;  4U1B A;  1YJ3 A;  1CHM A;  3TB5 A;  2V3Z A;  4S00 A;  3Q6D A;  1XGO A;  4PNC A;  2GZ5 A;  2GG9 A;  1A16 A;  1XNZ A;  4FLK A;  2EA4 A;  3IU7 A;  1C27 A;  4OOK A;  2Q96 A;  2BWV A;  4HXX A;  4U6Z A;  4ZNG A;  4RZZ A;  5E5B A;  4S2R P;  1M35 A;  1WL9 A;  1YVM A;  2EVO A;  5CDL A;  3PKC A;  4U6J A;  2P98 A;  4FO7 A;  4IKT A;  4U6W A;  4RZY A;  3BIT A;  3BIQ A;  4A6V A;  4S2T P;  4FLL A;  4PV4 A;  5CLS A;  1BOA A;  1KQ0 A;  3D27 A;  4ZWU A;  2BHA A;  2BWW A;  4U71 A;  1XGM A;  1O0X A;  5JFR A;  2NQ7 A;  3MAT A;  2HOW A;  3FMR A;  1WBQ A;  1R5G A;  2P9A A;  5CE6 A;  3L24 A;  1YW7 A;  4JUQ A;  2OAZ A;  4KM3 A;  2GG5 A;  2BH3 A;  3BIP A;  2BWX A;  1C23 A;  1C21 A;  1MAT A;  1WY2 A;  1QZY A;  3MR1 A;  4IKR A;  4MAT A;  1B6A A;  3IG4 A;  1QXW A;  2IW2 A;  3PKD A;  5D6E A;  3IU8 A;  4IKS A;  4R60 A;  2OKN A;  4Z7M A;  5FCH A;  2BWU A;  2V3Y A;  4ZWP A;  5CDV A;  4IF7 A;  5CIK A;  2BHD A;  4FKC A;  2NQ6 A;  1YW8 A;  2GG3 A;  2B3K A;  4ZWO A;  5JI6 A;  2BB7 A;  2Q93 A;  1C22 A;  1WN1 A;  2V6C A;  5D6F A;  1N51 A;  2GGB A;  1YW9 A;  4IDY A;  5CDE A;  4IEC A;  3MX6 A;  3ROR A;  1KQ9 A;  2G6P A;  3S6B A;  4FLI A;  2GGC A;  2GG2 A;  4U70 A;  2BHB A;  3PKA A;  1QXY A;  3FMQ A;  3PKB A;  2BHC A;  3RVA A;  1WLR A;  2ZSG A;  3FM3 A;  4EGE A;  1QXZ A;  2GG7 A;  2GU5 A;  3PKE A;  4U6E A;  4S01 A;  2BN7 A;  2BWS A;  1BN5 A;  4IKU A;  2GU7 A;  2EVM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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