2EVMA

Crystal structure of methionine aminopeptidase in complex with 5-(2,5-dichlorophenyl)furan-2-carboxylic acid
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
259
structure length
259
Chain Sequence
SIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural analysis of metalloform-selective inhibition of methionine aminopeptidase.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
molecule tags Hydrolase
source organism Escherichia coli
total genus 86
structure length 259
sequence length 259
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-10-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2evmA00
2EA2A 3D27A 3L7GA 2GGCA 2P98A 3Q6DA 4ZWPA 2BWWA 5CDLA 5FCFA 3MR1A 2BWTA 1XNZA 1C24A 5CDVA 2G6PA 2GU6A 4IKSA 1QXYA 2EVMA 4FO8A 4IU6A 1BN5A 2ZSGA 5E5BA 2Q93A 1N51A 4OOKA 4FO7A 4JUQA 3RVAA 3PKBA 1Y1NA 1WKMA 5JHUA 2GG7A 1C23A 1YW7A 2B3KA 2P99A 3BIPA 2DFIA 1JAWA 4IKRA 2HOWA 3S6BA 1M35A 1XGOA 2BHBA 4FLJA 3CB5A 2BN7A 2GU5A 1CHMA 1KQ0A 1W2MA 2Q95A 2NQ7A 4IKTA 4FLLA 3IU9A 4U1BA 3PKCA 4U70A 2GG2A 1C22A 4RZZA 4U76A 2GG8A 4Z7MA 4U6EA 1A16A 4IKUA 5D6FA 1W7VA 1XGMA 1MATA 1QZYA 2GG5A 1WY2A 4HXXA 4RZYA 2GG3A 1R5HA 5CDEA 2BHDA 1QXZA 5D6EA 4ZNGA 4S00A 4U6WA 3BIQA 2Q96A 2V3YA 1WN1A 2GTXA 2Q94A 3IU8A 3L24A 2NQ6A 1C27A 1YJ3A 4U71A 1C21A 1WL9A 4IDYA 4FKCA 1KP0A 3IG4A 1O0XA 5CIKA 1WBQA 3TB5A 5JFRA 3MATA 2BWXA 3MX6A 5CE6A 4R60A 2EVCA 4EGEA 2P9AA 1YW8A 1R5GA 2BHCA 3CB6A 3IU7A 4ZWOA 2GU7A 2ADUA 4PNCA 4U75A 2B3HA 3PKDA 1B59A 1WLRA 1WL6A 1XGSA 2GG0A 4ZWUA 1YVMA 4U69A 2IW2A 2GZ5A 2OKNA 4MATA 2V6CA 3PKAA 4PV4A 5CNXA 2Q8KA 4FLIA 1KQ9A 4S2RP 4A6WA 4U6CA 2BWVA 2MATA 3BITA 2GGBA 4KM3A 4S01A 4U6JA 4U6ZA 5CLSA 5FCHA 5JI6A 3FMRA 2BWUA 3FMQA 4QR8A 1PV9A 4U73A 1QXWA 4IF7A 4RGZ1 2OAZA 4A6VA 4B28A 2BB7A 3CTZA 1B6AA 3PKEA 2EA4A 4IECA 2Q92A 4S2TP 2GA2A 3RORA 2BWSA 2V3XA 1YW9A 1R58A 2V3ZA 4FUKA 2EVOA 1BOAA 2B3LA 2GU4A 2GG9A 2BHAA 4IPAA 4FLKA 3FM3A 3TAVA 2BWYA 1XGNA 2BH3A
chains in the Genus database with same CATH superfamily
2EA2A 3D27A 3L7GA 2GGCA 2P98A 3Q6DA 4ZWPA 2BWWA 5CDLA 5FCFA 3MR1A 2BWTA 1XNZA 1C24A 5CDVA 2G6PA 2GU6A 4IKSA 1QXYA 2EVMA 4FO8A 4IU6A 1BN5A 2ZSGA 5E5BA 2Q93A 1N51A 4OOKA 4FO7A 4JUQA 3RVAA 3PKBA 1Y1NA 1WKMA 5JHUA 2GG7A 1C23A 1YW7A 2B3KA 2P99A 3BIPA 2DFIA 1JAWA 4IKRA 2HOWA 3S6BA 1M35A 1XGOA 2BHBA 4FLJA 3CB5A 2BN7A 2GU5A 1CHMA 1KQ0A 1W2MA 2Q95A 2NQ7A 4IKTA 4FLLA 3IU9A 4U1BA 3PKCA 4U70A 2GG2A 1C22A 4RZZA 4U76A 2GG8A 4Z7MA 4U6EA 1A16A 4IKUA 5D6FA 1W7VA 1XGMA 1MATA 1QZYA 2GG5A 1WY2A 4HXXA 4RZYA 2GG3A 1R5HA 5CDEA 2BHDA 1QXZA 5D6EA 4ZNGA 4S00A 4U6WA 3BIQA 2Q96A 2V3YA 1WN1A 2GTXA 2Q94A 3IU8A 3L24A 2NQ6A 1C27A 1YJ3A 4U71A 1C21A 1WL9A 4IDYA 4FKCA 1KP0A 3IG4A 1O0XA 5CIKA 1WBQA 3TB5A 5JFRA 3MATA 2BWXA 3MX6A 5CE6A 4R60A 2EVCA 4EGEA 2P9AA 1YW8A 1R5GA 2BHCA 3CB6A 3IU7A 4ZWOA 2GU7A 2ADUA 4PNCA 4U75A 2B3HA 3PKDA 1B59A 1WLRA 1WL6A 1XGSA 2GG0A 4ZWUA 1YVMA 4U69A 2IW2A 2GZ5A 2OKNA 4MATA 2V6CA 3PKAA 4PV4A 5CNXA 2Q8KA 4FLIA 1KQ9A 4S2RP 4A6WA 4U6CA 2BWVA 2MATA 3BITA 2GGBA 4KM3A 4S01A 4U6JA 4U6ZA 5CLSA 5FCHA 5JI6A 3FMRA 2BWUA 3FMQA 4QR8A 1PV9A 4U73A 1QXWA 4IF7A 4RGZ1 2OAZA 4A6VA 4B28A 2BB7A 3CTZA 1B6AA 3PKEA 2EA4A 4IECA 2Q92A 4S2TP 2GA2A 3RORA 2BWSA 2V3XA 1YW9A 1R58A 2V3ZA 4FUKA 2EVOA 1BOAA 2B3LA 2GU4A 2GG9A 2BHAA 4IPAA 4FLKA 3FM3A 3TAVA 2BWYA 1XGNA 2BH3A
chains in the Genus database with same CATH topology
2EA2A 3D27A 3L7GA 2GGCA 2P98A 3Q6DA 4ZWPA 2BWWA 5CDLA 5FCFA 3MR1A 2BWTA 1XNZA 1C24A 5CDVA 2G6PA 2GU6A 4IKSA 1QXYA 2EVMA 4FO8A 4IU6A 1BN5A 2ZSGA 5E5BA 2Q93A 1N51A 4OOKA 4FO7A 4JUQA 3RVAA 3PKBA 1Y1NA 1WKMA 5JHUA 2GG7A 1C23A 1YW7A 2B3KA 2P99A 3BIPA 2DFIA 1JAWA 4IKRA 2HOWA 3S6BA 1M35A 1XGOA 2BHBA 4FLJA 3CB5A 2BN7A 2GU5A 1CHMA 1KQ0A 1W2MA 2Q95A 2NQ7A 4IKTA 4FLLA 3IU9A 4U1BA 3PKCA 4U70A 2GG2A 1C22A 4RZZA 4U76A 2GG8A 4Z7MA 4U6EA 1A16A 4IKUA 5D6FA 1W7VA 1XGMA 1MATA 1QZYA 2GG5A 1WY2A 4HXXA 4RZYA 2GG3A 1R5HA 5CDEA 2BHDA 1QXZA 5D6EA 4ZNGA 4S00A 4U6WA 3BIQA 2Q96A 2V3YA 1WN1A 2GTXA 2Q94A 3IU8A 3L24A 2NQ6A 1C27A 1YJ3A 4U71A 1C21A 1WL9A 4IDYA 4FKCA 1KP0A 3IG4A 1O0XA 5CIKA 1WBQA 3TB5A 5JFRA 3MATA 2BWXA 3MX6A 5CE6A 4R60A 2EVCA 4EGEA 2P9AA 1YW8A 1R5GA 2BHCA 3CB6A 3IU7A 4ZWOA 2GU7A 2ADUA 4PNCA 4U75A 2B3HA 3PKDA 1B59A 1WLRA 1WL6A 1XGSA 2GG0A 4ZWUA 1YVMA 4U69A 2IW2A 2GZ5A 2OKNA 4MATA 2V6CA 3PKAA 4PV4A 5CNXA 2Q8KA 4FLIA 1KQ9A 4S2RP 4A6WA 4U6CA 2BWVA 2MATA 3BITA 2GGBA 4KM3A 4S01A 4U6JA 4U6ZA 5CLSA 5FCHA 5JI6A 3FMRA 2BWUA 3FMQA 4QR8A 1PV9A 4U73A 1QXWA 4IF7A 4RGZ1 2OAZA 4A6VA 4B28A 2BB7A 3CTZA 1B6AA 3PKEA 2EA4A 4IECA 2Q92A 4S2TP 2GA2A 3RORA 2BWSA 2V3XA 1YW9A 1R58A 2V3ZA 4FUKA 2EVOA 1BOAA 2B3LA 2GU4A 2GG9A 2BHAA 4IPAA 4FLKA 3FM3A 3TAVA 2BWYA 1XGNA 2BH3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EA2 A;  3D27 A;  3L7G A;  2GGC A;  2P98 A;  3Q6D A;  4ZWP A;  2BWW A;  5CDL A;  5FCF A;  3MR1 A;  2BWT A;  1XNZ A;  1C24 A;  5CDV A;  2G6P A;  2GU6 A;  4IKS A;  1QXY A;  2EVM A;  4FO8 A;  4IU6 A;  1BN5 A;  2ZSG A;  5E5B A;  2Q93 A;  1N51 A;  4OOK A;  4FO7 A;  4JUQ A;  3RVA A;  3PKB A;  1Y1N A;  1WKM A;  5JHU A;  2GG7 A;  1C23 A;  1YW7 A;  2B3K A;  2P99 A;  3BIP A;  2DFI A;  1JAW A;  4IKR A;  2HOW A;  3S6B A;  1M35 A;  1XGO A;  2BHB A;  4FLJ A;  3CB5 A;  2BN7 A;  2GU5 A;  1CHM A;  1KQ0 A;  1W2M A;  2Q95 A;  2NQ7 A;  4IKT A;  4FLL A;  3IU9 A;  4U1B A;  3PKC A;  4U70 A;  2GG2 A;  1C22 A;  4RZZ A;  4U76 A;  2GG8 A;  4Z7M A;  4U6E A;  1A16 A;  4IKU A;  5D6F A;  1W7V A;  1XGM A;  1MAT A;  1QZY A;  2GG5 A;  1WY2 A;  4HXX A;  4RZY A;  2GG3 A;  1R5H A;  5CDE A;  2BHD A;  1QXZ A;  5D6E A;  4ZNG A;  4S00 A;  4U6W A;  3BIQ A;  2Q96 A;  2V3Y A;  1WN1 A;  2GTX A;  2Q94 A;  3IU8 A;  3L24 A;  2NQ6 A;  1C27 A;  1YJ3 A;  4U71 A;  1C21 A;  1WL9 A;  4IDY A;  4FKC A;  1KP0 A;  3IG4 A;  1O0X A;  5CIK A;  1WBQ A;  3TB5 A;  5JFR A;  3MAT A;  2BWX A;  3MX6 A;  5CE6 A;  4R60 A;  2EVC A;  4EGE A;  2P9A A;  1YW8 A;  1R5G A;  2BHC A;  3CB6 A;  3IU7 A;  4ZWO A;  2GU7 A;  2ADU A;  4PNC A;  4U75 A;  2B3H A;  3PKD A;  1B59 A;  1WLR A;  1WL6 A;  1XGS A;  2GG0 A;  4ZWU A;  1YVM A;  4U69 A;  2IW2 A;  2GZ5 A;  2OKN A;  4MAT A;  2V6C A;  3PKA A;  4PV4 A;  5CNX A;  2Q8K A;  4FLI A;  1KQ9 A;  4S2R P;  4A6W A;  4U6C A;  2BWV A;  2MAT A;  3BIT A;  2GGB A;  4KM3 A;  4S01 A;  4U6J A;  4U6Z A;  5CLS A;  5FCH A;  5JI6 A;  3FMR A;  2BWU A;  3FMQ A;  4QR8 A;  1PV9 A;  4U73 A;  1QXW A;  4IF7 A;  4RGZ 1;  2OAZ A;  4A6V A;  4B28 A;  2BB7 A;  3CTZ A;  1B6A A;  3PKE A;  2EA4 A;  4IEC A;  2Q92 A;  4S2T P;  2GA2 A;  3ROR A;  2BWS A;  2V3X A;  1YW9 A;  1R58 A;  2V3Z A;  4FUK A;  2EVO A;  1BOA A;  2B3L A;  2GU4 A;  2GG9 A;  2BHA A;  4IPA A;  4FLK A;  3FM3 A;  3TAV A;  2BWY A;  1XGN A;  2BH3 A; 
#chains in the Genus database with same CATH topology
 2EA2 A;  3D27 A;  3L7G A;  2GGC A;  2P98 A;  3Q6D A;  4ZWP A;  2BWW A;  5CDL A;  5FCF A;  3MR1 A;  2BWT A;  1XNZ A;  1C24 A;  5CDV A;  2G6P A;  2GU6 A;  4IKS A;  1QXY A;  2EVM A;  4FO8 A;  4IU6 A;  1BN5 A;  2ZSG A;  5E5B A;  2Q93 A;  1N51 A;  4OOK A;  4FO7 A;  4JUQ A;  3RVA A;  3PKB A;  1Y1N A;  1WKM A;  5JHU A;  2GG7 A;  1C23 A;  1YW7 A;  2B3K A;  2P99 A;  3BIP A;  2DFI A;  1JAW A;  4IKR A;  2HOW A;  3S6B A;  1M35 A;  1XGO A;  2BHB A;  4FLJ A;  3CB5 A;  2BN7 A;  2GU5 A;  1CHM A;  1KQ0 A;  1W2M A;  2Q95 A;  2NQ7 A;  4IKT A;  4FLL A;  3IU9 A;  4U1B A;  3PKC A;  4U70 A;  2GG2 A;  1C22 A;  4RZZ A;  4U76 A;  2GG8 A;  4Z7M A;  4U6E A;  1A16 A;  4IKU A;  5D6F A;  1W7V A;  1XGM A;  1MAT A;  1QZY A;  2GG5 A;  1WY2 A;  4HXX A;  4RZY A;  2GG3 A;  1R5H A;  5CDE A;  2BHD A;  1QXZ A;  5D6E A;  4ZNG A;  4S00 A;  4U6W A;  3BIQ A;  2Q96 A;  2V3Y A;  1WN1 A;  2GTX A;  2Q94 A;  3IU8 A;  3L24 A;  2NQ6 A;  1C27 A;  1YJ3 A;  4U71 A;  1C21 A;  1WL9 A;  4IDY A;  4FKC A;  1KP0 A;  3IG4 A;  1O0X A;  5CIK A;  1WBQ A;  3TB5 A;  5JFR A;  3MAT A;  2BWX A;  3MX6 A;  5CE6 A;  4R60 A;  2EVC A;  4EGE A;  2P9A A;  1YW8 A;  1R5G A;  2BHC A;  3CB6 A;  3IU7 A;  4ZWO A;  2GU7 A;  2ADU A;  4PNC A;  4U75 A;  2B3H A;  3PKD A;  1B59 A;  1WLR A;  1WL6 A;  1XGS A;  2GG0 A;  4ZWU A;  1YVM A;  4U69 A;  2IW2 A;  2GZ5 A;  2OKN A;  4MAT A;  2V6C A;  3PKA A;  4PV4 A;  5CNX A;  2Q8K A;  4FLI A;  1KQ9 A;  4S2R P;  4A6W A;  4U6C A;  2BWV A;  2MAT A;  3BIT A;  2GGB A;  4KM3 A;  4S01 A;  4U6J A;  4U6Z A;  5CLS A;  5FCH A;  5JI6 A;  3FMR A;  2BWU A;  3FMQ A;  4QR8 A;  1PV9 A;  4U73 A;  1QXW A;  4IF7 A;  4RGZ 1;  2OAZ A;  4A6V A;  4B28 A;  2BB7 A;  3CTZ A;  1B6A A;  3PKE A;  2EA4 A;  4IEC A;  2Q92 A;  4S2T P;  2GA2 A;  3ROR A;  2BWS A;  2V3X A;  1YW9 A;  1R58 A;  2V3Z A;  4FUK A;  2EVO A;  1BOA A;  2B3L A;  2GU4 A;  2GG9 A;  2BHA A;  4IPA A;  4FLK A;  3FM3 A;  3TAV A;  2BWY A;  1XGN A;  2BH3 A; 
#chains in the Genus database with same CATH homology
 2EA2 A;  3D27 A;  3L7G A;  2GGC A;  2P98 A;  3Q6D A;  4ZWP A;  2BWW A;  5CDL A;  5FCF A;  3MR1 A;  2BWT A;  1XNZ A;  1C24 A;  5CDV A;  2G6P A;  2GU6 A;  4IKS A;  1QXY A;  2EVM A;  4FO8 A;  4IU6 A;  1BN5 A;  2ZSG A;  5E5B A;  2Q93 A;  1N51 A;  4OOK A;  4FO7 A;  4JUQ A;  3RVA A;  3PKB A;  1Y1N A;  1WKM A;  5JHU A;  2GG7 A;  1C23 A;  1YW7 A;  2B3K A;  2P99 A;  3BIP A;  2DFI A;  1JAW A;  4IKR A;  2HOW A;  3S6B A;  1M35 A;  1XGO A;  2BHB A;  4FLJ A;  3CB5 A;  2BN7 A;  2GU5 A;  1CHM A;  1KQ0 A;  1W2M A;  2Q95 A;  2NQ7 A;  4IKT A;  4FLL A;  3IU9 A;  4U1B A;  3PKC A;  4U70 A;  2GG2 A;  1C22 A;  4RZZ A;  4U76 A;  2GG8 A;  4Z7M A;  4U6E A;  1A16 A;  4IKU A;  5D6F A;  1W7V A;  1XGM A;  1MAT A;  1QZY A;  2GG5 A;  1WY2 A;  4HXX A;  4RZY A;  2GG3 A;  1R5H A;  5CDE A;  2BHD A;  1QXZ A;  5D6E A;  4ZNG A;  4S00 A;  4U6W A;  3BIQ A;  2Q96 A;  2V3Y A;  1WN1 A;  2GTX A;  2Q94 A;  3IU8 A;  3L24 A;  2NQ6 A;  1C27 A;  1YJ3 A;  4U71 A;  1C21 A;  1WL9 A;  4IDY A;  4FKC A;  1KP0 A;  3IG4 A;  1O0X A;  5CIK A;  1WBQ A;  3TB5 A;  5JFR A;  3MAT A;  2BWX A;  3MX6 A;  5CE6 A;  4R60 A;  2EVC A;  4EGE A;  2P9A A;  1YW8 A;  1R5G A;  2BHC A;  3CB6 A;  3IU7 A;  4ZWO A;  2GU7 A;  2ADU A;  4PNC A;  4U75 A;  2B3H A;  3PKD A;  1B59 A;  1WLR A;  1WL6 A;  1XGS A;  2GG0 A;  4ZWU A;  1YVM A;  4U69 A;  2IW2 A;  2GZ5 A;  2OKN A;  4MAT A;  2V6C A;  3PKA A;  4PV4 A;  5CNX A;  2Q8K A;  4FLI A;  1KQ9 A;  4S2R P;  4A6W A;  4U6C A;  2BWV A;  2MAT A;  3BIT A;  2GGB A;  4KM3 A;  4S01 A;  4U6J A;  4U6Z A;  5CLS A;  5FCH A;  5JI6 A;  3FMR A;  2BWU A;  3FMQ A;  4QR8 A;  1PV9 A;  4U73 A;  1QXW A;  4IF7 A;  4RGZ 1;  2OAZ A;  4A6V A;  4B28 A;  2BB7 A;  3CTZ A;  1B6A A;  3PKE A;  2EA4 A;  4IEC A;  2Q92 A;  4S2T P;  2GA2 A;  3ROR A;  2BWS A;  2V3X A;  1YW9 A;  1R58 A;  2V3Z A;  4FUK A;  2EVO A;  1BOA A;  2B3L A;  2GU4 A;  2GG9 A;  2BHA A;  4IPA A;  4FLK A;  3FM3 A;  3TAV A;  2BWY A;  1XGN A;  2BH3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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