2F6ZA

Protein tyrosine phosphatase 1b with sulfamic acid inhibitors
Total Genus 110
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
110
sequence length
297
structure length
297
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Tyrosine-protein phosphatase, non-receptor type 1
total genus 110
structure length 297
sequence length 297
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2005-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2f6zA00
3PS5A 4GRYA 1OHDA 3QCFA 3GXGA 4RHGA 2BIJA 3N0AA 1XXVA 1G1GA 3I36A 2B4OA 3QCJA 3V0GA 1T4JA 2HC2A 2IMGA 2QBPA 4NX8A 2ESBA 4HJQA 4ICZA 3V0DA 4ZRTA 1G4US 2PA5A 3CWEA 2I6PA 1U25A 3MOZA 3V0FA 4QBWA 1FPRA 3ZM2A 1RPMA 3EU0A 3RO1A 1GFYA 3QCIA 1C84A 1ZCLA 2PQ5A 2I6IA 4ERCA 1G7GA 2RF6A 2AZRA 3F99A 5KA7A 1NNYA 3ZM0A 4D3RA 2QDCA 4GE5A 5BZXA 1WAXA 3F9AA 5BUGA 5K22A 4R0SA 1WCHA 4WU2A 2I42A 4GRZA 1OETA 4GWFA 3QCNA 1OESA 5KABA 1NWLA 2B4PA 3QCKA 3S4OA 1C85A 2QBSA 1NZ7A 3ZM1A 1LARA 3QCBA 1C87A 2J16B 4Z6BA 2SHPA 3D42A 2VEVA 2NT7A 2M3VA 3S3HA 1ZZWA 1GWZA 4QUNA 2E0TA 2I4EA 3QCCA 1YPTA 2QBQA 1NO6A 1G4WR 4GFVA 2P4DA 1M3GA 3ZMQA 1D5RA 3AWGA 3B7OA 3S3EA 2MBCA 3MOWA 3RZ2A 2BV5A 2G59A 3ZMPA 4OHLA 4DGPA 1XXPA 2CM8A 2CNEA 2BZLA 1Q1MA 4NNDA 4GE6A 3D1OA 2F6TA 1YN9A 4QBEA 5M43A 2CNIA 2CMAA 1LYVA 3H2XA 5KA3A 2I6OA 2F6WA 2F46A 1YGUA 1BZCA 2F6ZA 2HVLA 4IKCA 3RGOA 2ZN7A 4QAHA 5KADA 3V0JA 2CM2A 5HDEA 2YDUA 1OHEA 3EAXA 1PA1A 3F9BA 2ZMMA 3NMEA 2OC3A 4RH5A 3O4UA 4D3QA 2OUDA 3O5XA 3ZV2A 4ZN5A 4R0TA 2HNQA 2H04A 1QXKA 4KYQA 5LXQB 2B4SA 4PYHA 2CNGA 2H03A 1VHRA 4Y14A 2FJNA 1OHCA 2GWOA 3QCGA 2B4UA 1RXDA 4JNBA 4NYHA 1PH0A 4B04A 4RI5A 1YTNA 4RI4A 2J17A 2Q05A 3V0IA 4Y2EA 2B3OA 2HC1A 4JBCA 3D9CA 4KI9A 1Q6NA 5KA0A 2I75A 1ZCKA 1OEOX 2C46A 5EHPA 3BLTA 3MMJA 3A5JA 2BGDA 4RH9A 4JMKA 3AWEA 1YZ4A 3A5KA 3S4EA 3M4UA 1ECVA 1AAXA 1FQ1A 2NLKA 1C88A 1P15A 1BZJA 1XBOA 1G1FA 5GTJA 4YR8B 3LJ8A 2PBNA 1YTSA 1NWEA 1U26A 1OEUA 4NWGA 3D1HA 5KAAA 1ZC0A 1YWFA 3I7ZA 5K23A 2J16A 3BLUA 2CNFA 2FJMA 1PA9A 4H34A 1YTWA 1X24A 1G1HA 1I9SA 1EEOA 2HCMA 3F41A 4TVVA 1Q6SA 2NZ6A 3S3FA 2JJDA 1OEVA 3SR9A 2A3KA 3D44A 3AWFA 2QEPA 1XRIA 4GFUA 1NL9A 2VEUA 3RGQA 4NWFA 1EENA 4PVGA 2QCTA 4OHHA 4OHDA 1YFOA 3QCLA 1MKPA 1V3AA 2I4GA 3BRHA 5K25A 5KA9A 1R6HA 2FH7A 1WRMA 1XM2A 2I1YA 1ONZA 2QCJA 2WGPA 5IBSA 4WOHA 2F6YA 4H1OA 3OMHA 3CM3A 3V0EA 2HXPA 1L8KA 4RDDA 4BPCA 5KA2A 3O3LA 1PTYA 1Q6MA 4YAAA 3D1QA 2VEXA 4WTYA 1U24A 1SUGA 2A8BA 1KAVA 2F6VA 2OZ5A 3QKQA 5MMZB 3QCEA 2HB1A 2NV5A 2H4VA 2OOQA 2QBRA 1FPZA 2I3RA 1PTUA 4J51A 2CFVA 2QDPA 4MBBA 2NTAA 4HJPA 2PSZA 3BM8A 5K24A 3O4TA 1G7FA 4R30A 1L8GA 2GJTA 5I6VA 2I6JA 3SMEA 2QDMA 5K9VA 2G6ZA 4HRFA 5EHRA 1J4XA 2CMBA 2I3UA 2H02A 4DGXA 1QZ0A 2GP0A 1Q6TA 1KAKA 3I80A 2Q47A 4OHEA 1BZHA 3QCMA 2AHSA 3U96A 2F70A 2I5XA 1PTTA 4WU3A 2B49A 3EZZA 1YGRA 2BGEA 4JMJA 5BX1A 3S3KA 1C86A 1OEMX 5KACA 3OLRA 2R0BA 4KYRA 3EMUA 3V0HA 2I6MA 2CM3A 3EB1A 3QCDA 1JLNA 1C83A 2HY3A 1PXHA 2H4GA 3F81A 3O4SA 4OHIA 1I9TA 1A5YA 2HNPA 2PI7A 2VEWA 2P6XA 2DXPA 4QAPA 1T48A 2B07A 5BZZA 4ZI4A 1Q6PA 4S0GA 1JF7A 2C7SA 4BJOA 4D3PA 4GE2A 4GS0A 1Q6JA 3ZM3A 3QKPA 2Y2FA 5KA4A 5KA1A 2CNHA 3GXHA 2VEYA 2CMCA 1I57A 1T49A 5J8RA 4AZ1A 2PT0A 5K9WA 5IBMA 2Y96A 4I8NA 2H4KA 5AWXA 2CM7A 1ONYA 3QCHA 2NT2A 4QUMA 2F71A 2CJZA 4RKKA 2I4HA 1LQFA 1PYNA 2F6FA 1PTVA 5KA8A
chains in the Genus database with same CATH superfamily
3MVNA 3PS5A 4GRYA 1OHDA 3QCFA 3GXGA 4RHGA 2JFFA 2BIJA 3N0AA 1XXVA 1G1GA 3I36A 2B4OA 2Y68A 3QCJA 3V0GA 3ZM6A 1T4JA 2HC2A 2IMGA 2QBPA 4NX8A 2ESBA 4HJQA 4ICZA 3V0DA 4ZRTA 1G4US 2Y1OA 2PA5A 3N2AA 3CWEA 2I6PA 1U25A 3MOZA 3V0FA 4QBWA 1FPRA 3ZM2A 1RPMA 3EU0A 3RO1A 2AM2A 1GFYA 3QCIA 1C84A 1ZCLA 2PQ5A 2I6IA 4ERCA 1G7GA 2RF6A 2AZRA 3PYZA 1O5ZA 3F99A 5KA7A 1NNYA 2VTDA 3ZM0A 4D3RA 2QDCA 4GE5A 5BZXA 1WAXA 3F9AA 5BUGA 5K22A 4R0SA 1WCHA 4WU2A 2I42A 4GRZA 1OETA 4GWFA 3QCNA 1OESA 5KABA 1NWLA 2B4PA 3QCKA 3S4OA 1C85A 2QBSA 1NZ7A 3ZM1A 1LARA 3QCBA 1C87A 4QDIA 2J16B 4Z6BA 2SHPA 3D42A 2VEVA 1J6UA 3UAGA 2NT7A 4QF5A 2M3VA 3S3HA 1ZZWA 1GWZA 4QUNA 2E0TA 2I4EA 3QCCA 1YPTA 2QBQA 1NO6A 1G4WR 3LK7A 4GFVA 2P4DA 1M3GA 3ZMQA 1D5RA 4CVMA 4CVKA 3AWGA 3B7OA 3S3EA 2MBCA 3MOWA 2Y67A 3RZ2A 2BV5A 2G59A 3ZMPA 4OHLA 4DGPA 1JBWA 2WTZA 1XXPA 2CM8A 2CNEA 2BZLA 1Q1MA 4NNDA 4GE6A 3D1OA 2F6TA 1YN9A 2F00A 4QBEA 5M43A 2CNIA 2CMAA 1LYVA 3H2XA 5KA3A 2I6OA 2F6WA 2F46A 1YGUA 2Y66A 4CVLA 1BZCA 2F6ZA 2HVLA 4IKCA 3RGOA 2ZN7A 4QAHA 5KADA 3V0JA 2CM2A 2VORA 5HDEA 2YDUA 1OHEA 3EAXA 1PA1A 1GQYA 3F9BA 2ZMMA 3NMEA 2WJPA 2OC3A 1E0DA 1JBVA 4RH5A 3O4UA 4D3QA 2OUDA 3O5XA 3ZV2A 4ZN5A 4R0TA 2HNQA 2H04A 1QXKA 4KYQA 1EEHA 5LXQB 2B4SA 2UUOA 4PYHA 4BUBA 2CNGA 2H03A 1VHRA 4Y14A 2FJNA 1OHCA 2GWOA 2GCBA 3QCGA 2B4UA 1RXDA 4JNBA 4NYHA 1PH0A 2AM1A 4B04A 4RI5A 1YTNA 4RI4A 2J17A 2Q05A 3V0IA 4Y2EA 2B3OA 2HC1A 4JBCA 4C13A 3D9CA 3QCZA 4KI9A 1Q6NA 5KA0A 2I75A 1ZCKA 1OEOX 2C46A 5EHPA 3BLTA 3MMJA 3A5JA 2BGDA 4RH9A 4JMKA 3AWEA 1YZ4A 5A5FA 3A5KA 3S4EA 3M4UA 1ECVA 1AAXA 1FQ1A 2NLKA 1C88A 4UAGA 1P15A 1BZJA 1XBOA 1G1FA 5GTJA 4YR8B 3LJ8A 1W78A 2PBNA 1YTSA 1NWEA 1U26A 1OEUA 4NWGA 3D1HA 5KAAA 2X5OA 1FGSA 1ZC0A 1YWFA 4ZIYA 3I7ZA 5K23A 2J16A 3BLUA 2CNFA 2FJMA 1PA9A 4H34A 1YTWA 2JFGA 1X24A 1G1HA 1I9SA 2GC5A 1EEOA 2HCMA 3F41A 4TVVA 1Q6SA 2NZ6A 3S3FA 2JJDA 1OEVA 3SR9A 2A3KA 3D44A 3AWFA 2QEPA 1XRIA 4GFUA 1P31A 1NL9A 2VEUA 3RGQA 4NWFA 1EENA 4PVGA 2QCTA 4OHHA 3HN7A 4OHDA 1YFOA 3QCLA 1MKPA 1V3AA 2I4GA 4C12A 3BRHA 2UUPA 5K25A 5KA9A 1R6HA 2FH7A 1WRMA 2JFHA 1XM2A 2I1YA 1ONZA 2QCJA 2WGPA 5IBSA 4WOHA 2F6YA 4H1OA 3OMHA 3CM3A 2GC6A 3V0EA 1GG4A 2HXPA 1L8KA 1P3DA 4RDDA 4BPCA 1E8CA 5KA2A 3O3LA 1PTYA 1Q6MA 4YAAA 3D1QA 2VEXA 4WTYA 1U24A 2UAGA 1SUGA 2A8BA 1KAVA 5A5EA 2F6VA 1W7KA 2OZ5A 3QKQA 5MMZB 3QCEA 2HB1A 2GCAA 2NV5A 2H4VA 2OOQA 2QBRA 1FPZA 2I3RA 1PTUA 4J51A 2CFVA 2QDPA 4MBBA 2NTAA 4HJPA 2PSZA 3BM8A 5K24A 3O4TA 1G7FA 4R30A 1L8GA 2GJTA 5I6VA 2I6JA 3SMEA 2QDMA 5K9VA 2G6ZA 4HRFA 5EHRA 1J4XA 2CMBA 2I3UA 2H02A 4DGXA 1QZ0A 2GP0A 1Q6TA 3NRSA 1KAKA 3I80A 2Q47A 4OHEA 1BZHA 4HV4A 3QCMA 2AHSA 3U96A 2F70A 2I5XA 1PTTA 4WU3A 2B49A 3EZZA 1YGRA 2BGEA 4JMJA 2VOSA 5BX1A 3S3KA 1C86A 1OEMX 5KACA 3ZL8A 3OLRA 2R0BA 4KYRA 3EMUA 3V0HA 2I6MA 2CM3A 3EB1A 3QCDA 1JLNA 4BUCA 1C83A 2HY3A 1PXHA 2H4GA 3F81A 3O4SA 2XPCA 4OHIA 1I9TA 1A5YA 2HNPA 2PI7A 2VEWA 2P6XA 2DXPA 4QAPA 1T48A 2B07A 5BZZA 4ZI4A 1Q6PA 2VTEA 4S0GA 1JF7A 2C7SA 4BJOA 4D3PA 1GQQA 1UAGA 4GE2A 4GS0A 1Q6JA 3ZM5A 3ZM3A 3QKPA 2Y2FA 5KA4A 5KA1A 2CNHA 3GXHA 2VEYA 2CMCA 1I57A 1T49A 5J8RA 4AZ1A 2PT0A 5K9WA 5IBMA 2Y96A 4I8NA 2H4KA 5AWXA 2CM7A 1ONYA 3QCHA 2NT2A 4QUMA 2F71A 2CJZA 4RKKA 2I4HA 1LQFA 1PYNA 2F6FA 2XJAA 1PTVA 5KA8A
chains in the Genus database with same CATH topology
3PS5A 4GRYA 1OHDA 3QCFA 3GXGA 4RHGA 2BIJA 3N0AA 1XXVA 1G1GA 3I36A 2B4OA 3QCJA 3V0GA 1T4JA 2HC2A 2IMGA 2QBPA 4NX8A 2ESBA 4HJQA 4ICZA 3V0DA 4ZRTA 1G4US 2PA5A 3CWEA 2I6PA 1U25A 3MOZA 3V0FA 4QBWA 1FPRA 3ZM2A 1RPMA 3EU0A 3RO1A 1GFYA 3QCIA 1C84A 1ZCLA 2PQ5A 2I6IA 4ERCA 1G7GA 2RF6A 2AZRA 3F99A 5KA7A 1NNYA 3ZM0A 4D3RA 2QDCA 4GE5A 5BZXA 1WAXA 3F9AA 5BUGA 5K22A 4R0SA 1WCHA 4WU2A 2I42A 4GRZA 1OETA 4GWFA 3QCNA 1OESA 5KABA 1NWLA 2B4PA 3QCKA 3S4OA 1C85A 2QBSA 1NZ7A 3ZM1A 1LARA 3QCBA 1C87A 2J16B 4Z6BA 2SHPA 3D42A 2VEVA 2NT7A 2M3VA 3S3HA 1ZZWA 1GWZA 4QUNA 2E0TA 2I4EA 3QCCA 1YPTA 2QBQA 1NO6A 1G4WR 4GFVA 2P4DA 1M3GA 3ZMQA 1D5RA 3AWGA 3B7OA 3S3EA 2MBCA 3MOWA 3RZ2A 2BV5A 2G59A 3ZMPA 4OHLA 4DGPA 1XXPA 2CM8A 2CNEA 2BZLA 1Q1MA 4NNDA 4GE6A 3D1OA 2F6TA 1YN9A 4QBEA 5M43A 2CNIA 2CMAA 1LYVA 3H2XA 5KA3A 2I6OA 2F6WA 2F46A 1YGUA 1BZCA 2F6ZA 2HVLA 4IKCA 3RGOA 2ZN7A 4QAHA 5KADA 3V0JA 2CM2A 5HDEA 2YDUA 1OHEA 3EAXA 1PA1A 3F9BA 2ZMMA 3NMEA 2OC3A 4RH5A 3O4UA 4D3QA 2OUDA 3O5XA 3ZV2A 4ZN5A 4R0TA 2HNQA 2H04A 1QXKA 4KYQA 5LXQB 2B4SA 4PYHA 2CNGA 2H03A 1VHRA 4Y14A 2FJNA 1OHCA 2GWOA 3QCGA 2B4UA 1RXDA 4JNBA 4NYHA 1PH0A 4B04A 4RI5A 1YTNA 4RI4A 2J17A 2Q05A 3V0IA 4Y2EA 2B3OA 2HC1A 4JBCA 3D9CA 4KI9A 1Q6NA 5KA0A 2I75A 1ZCKA 1OEOX 2C46A 5EHPA 3BLTA 3MMJA 3A5JA 2BGDA 4RH9A 4JMKA 3AWEA 1YZ4A 3A5KA 3S4EA 3M4UA 1ECVA 1AAXA 1FQ1A 2NLKA 1C88A 1P15A 1BZJA 1XBOA 1G1FA 5GTJA 4YR8B 3LJ8A 2PBNA 1YTSA 1NWEA 1U26A 1OEUA 4NWGA 3D1HA 5KAAA 1ZC0A 1YWFA 3I7ZA 5K23A 2J16A 3BLUA 2CNFA 2FJMA 1PA9A 4H34A 1YTWA 1X24A 1G1HA 1I9SA 1EEOA 2HCMA 3F41A 4TVVA 1Q6SA 2NZ6A 3S3FA 2JJDA 1OEVA 3SR9A 2A3KA 3D44A 3AWFA 2QEPA 1XRIA 4GFUA 1NL9A 2VEUA 3RGQA 4NWFA 1EENA 4PVGA 2QCTA 4OHHA 4OHDA 1YFOA 3QCLA 1MKPA 1V3AA 2I4GA 3BRHA 5K25A 5KA9A 1R6HA 2FH7A 1WRMA 1XM2A 2I1YA 1ONZA 2QCJA 2WGPA 5IBSA 4WOHA 2F6YA 4H1OA 3OMHA 3CM3A 3V0EA 2HXPA 1L8KA 4RDDA 4BPCA 5KA2A 3O3LA 1PTYA 1Q6MA 4YAAA 3D1QA 2VEXA 4WTYA 1U24A 1SUGA 2A8BA 1KAVA 2F6VA 2OZ5A 3QKQA 5MMZB 3QCEA 2HB1A 2NV5A 2H4VA 2OOQA 2QBRA 1FPZA 2I3RA 1PTUA 4J51A 2CFVA 2QDPA 4MBBA 2NTAA 4HJPA 2PSZA 3BM8A 5K24A 3O4TA 1G7FA 4R30A 1L8GA 2GJTA 5I6VA 2I6JA 3SMEA 2QDMA 5K9VA 2G6ZA 4HRFA 5EHRA 1J4XA 2CMBA 2I3UA 2H02A 4DGXA 1QZ0A 2GP0A 1Q6TA 1KAKA 3I80A 2Q47A 4OHEA 1BZHA 3QCMA 2AHSA 3U96A 2F70A 2I5XA 1PTTA 4WU3A 2B49A 3EZZA 1YGRA 2BGEA 4JMJA 5BX1A 3S3KA 1C86A 1OEMX 5KACA 3OLRA 2R0BA 4KYRA 3EMUA 3V0HA 2I6MA 2CM3A 3EB1A 3QCDA 1JLNA 1C83A 2HY3A 1PXHA 2H4GA 3F81A 3O4SA 4OHIA 1I9TA 1A5YA 2HNPA 2PI7A 2VEWA 2P6XA 2DXPA 4QAPA 1T48A 2B07A 5BZZA 4ZI4A 1Q6PA 4S0GA 1JF7A 2C7SA 4BJOA 4D3PA 4GE2A 4GS0A 1Q6JA 3ZM3A 3QKPA 2Y2FA 5KA4A 5KA1A 2CNHA 3GXHA 2VEYA 2CMCA 1I57A 1T49A 5J8RA 4AZ1A 2PT0A 5K9WA 5IBMA 2Y96A 4I8NA 2H4KA 5AWXA 2CM7A 1ONYA 3QCHA 2NT2A 4QUMA 2F71A 2CJZA 4RKKA 2I4HA 1LQFA 1PYNA 2F6FA 1PTVA 5KA8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PS5 A;  4GRY A;  1OHD A;  3QCF A;  3GXG A;  4RHG A;  2BIJ A;  3N0A A;  1XXV A;  1G1G A;  3I36 A;  2B4O A;  3QCJ A;  3V0G A;  1T4J A;  2HC2 A;  2IMG A;  2QBP A;  4NX8 A;  2ESB A;  4HJQ A;  4ICZ A;  3V0D A;  4ZRT A;  1G4U S;  2PA5 A;  3CWE A;  2I6P A;  1U25 A;  3MOZ A;  3V0F A;  4QBW A;  1FPR A;  3ZM2 A;  1RPM A;  3EU0 A;  3RO1 A;  1GFY A;  3QCI A;  1C84 A;  1ZCL A;  2PQ5 A;  2I6I A;  4ERC A;  1G7G A;  2RF6 A;  2AZR A;  3F99 A;  5KA7 A;  1NNY A;  3ZM0 A;  4D3R A;  2QDC A;  4GE5 A;  5BZX A;  1WAX A;  3F9A A;  5BUG A;  5K22 A;  4R0S A;  1WCH A;  4WU2 A;  2I42 A;  4GRZ A;  1OET A;  4GWF A;  3QCN A;  1OES A;  5KAB A;  1NWL A;  2B4P A;  3QCK A;  3S4O A;  1C85 A;  2QBS A;  1NZ7 A;  3ZM1 A;  1LAR A;  3QCB A;  1C87 A;  2J16 B;  4Z6B A;  2SHP A;  3D42 A;  2VEV A;  2NT7 A;  2M3V A;  3S3H A;  1ZZW A;  1GWZ A;  4QUN A;  2E0T A;  2I4E A;  3QCC A;  1YPT A;  2QBQ A;  1NO6 A;  1G4W R;  4GFV A;  2P4D A;  1M3G A;  3ZMQ A;  1D5R A;  3AWG A;  3B7O A;  3S3E A;  2MBC A;  3MOW A;  3RZ2 A;  2BV5 A;  2G59 A;  3ZMP A;  4OHL A;  4DGP A;  1XXP A;  2CM8 A;  2CNE A;  2BZL A;  1Q1M A;  4NND A;  4GE6 A;  3D1O A;  2F6T A;  1YN9 A;  4QBE A;  5M43 A;  2CNI A;  2CMA A;  1LYV A;  3H2X A;  5KA3 A;  2I6O A;  2F6W A;  2F46 A;  1YGU A;  1BZC A;  2F6Z A;  2HVL A;  4IKC A;  3RGO A;  2ZN7 A;  4QAH A;  5KAD A;  3V0J A;  2CM2 A;  5HDE A;  2YDU A;  1OHE A;  3EAX A;  1PA1 A;  3F9B A;  2ZMM A;  3NME A;  2OC3 A;  4RH5 A;  3O4U A;  4D3Q A;  2OUD A;  3O5X A;  3ZV2 A;  4ZN5 A;  4R0T A;  2HNQ A;  2H04 A;  1QXK A;  4KYQ A;  5LXQ B;  2B4S A;  4PYH A;  2CNG A;  2H03 A;  1VHR A;  4Y14 A;  2FJN A;  1OHC A;  2GWO A;  3QCG A;  2B4U A;  1RXD A;  4JNB A;  4NYH A;  1PH0 A;  4B04 A;  4RI5 A;  1YTN A;  4RI4 A;  2J17 A;  2Q05 A;  3V0I A;  4Y2E A;  2B3O A;  2HC1 A;  4JBC A;  3D9C A;  4KI9 A;  1Q6N A;  5KA0 A;  2I75 A;  1ZCK A;  1OEO X;  2C46 A;  5EHP A;  3BLT A;  3MMJ A;  3A5J A;  2BGD A;  4RH9 A;  4JMK A;  3AWE A;  1YZ4 A;  3A5K A;  3S4E A;  3M4U A;  1ECV A;  1AAX A;  1FQ1 A;  2NLK A;  1C88 A;  1P15 A;  1BZJ A;  1XBO A;  1G1F A;  5GTJ A;  4YR8 B;  3LJ8 A;  2PBN A;  1YTS A;  1NWE A;  1U26 A;  1OEU A;  4NWG A;  3D1H A;  5KAA A;  1ZC0 A;  1YWF A;  3I7Z A;  5K23 A;  2J16 A;  3BLU A;  2CNF A;  2FJM A;  1PA9 A;  4H34 A;  1YTW A;  1X24 A;  1G1H A;  1I9S A;  1EEO A;  2HCM A;  3F41 A;  4TVV A;  1Q6S A;  2NZ6 A;  3S3F A;  2JJD A;  1OEV A;  3SR9 A;  2A3K A;  3D44 A;  3AWF A;  2QEP A;  1XRI A;  4GFU A;  1NL9 A;  2VEU A;  3RGQ A;  4NWF A;  1EEN A;  4PVG A;  2QCT A;  4OHH A;  4OHD A;  1YFO A;  3QCL A;  1MKP A;  1V3A A;  2I4G A;  3BRH A;  5K25 A;  5KA9 A;  1R6H A;  2FH7 A;  1WRM A;  1XM2 A;  2I1Y A;  1ONZ A;  2QCJ A;  2WGP A;  5IBS A;  4WOH A;  2F6Y A;  4H1O A;  3OMH A;  3CM3 A;  3V0E A;  2HXP A;  1L8K A;  4RDD A;  4BPC A;  5KA2 A;  3O3L A;  1PTY A;  1Q6M A;  4YAA A;  3D1Q A;  2VEX A;  4WTY A;  1U24 A;  1SUG A;  2A8B A;  1KAV A;  2F6V A;  2OZ5 A;  3QKQ A;  5MMZ B;  3QCE A;  2HB1 A;  2NV5 A;  2H4V A;  2OOQ A;  2QBR A;  1FPZ A;  2I3R A;  1PTU A;  4J51 A;  2CFV A;  2QDP A;  4MBB A;  2NTA A;  4HJP A;  2PSZ A;  3BM8 A;  5K24 A;  3O4T A;  1G7F A;  4R30 A;  1L8G A;  2GJT A;  5I6V A;  2I6J A;  3SME A;  2QDM A;  5K9V A;  2G6Z A;  4HRF A;  5EHR A;  1J4X A;  2CMB A;  2I3U A;  2H02 A;  4DGX A;  1QZ0 A;  2GP0 A;  1Q6T A;  1KAK A;  3I80 A;  2Q47 A;  4OHE A;  1BZH A;  3QCM A;  2AHS A;  3U96 A;  2F70 A;  2I5X A;  1PTT A;  4WU3 A;  2B49 A;  3EZZ A;  1YGR A;  2BGE A;  4JMJ A;  5BX1 A;  3S3K A;  1C86 A;  1OEM X;  5KAC A;  3OLR A;  2R0B A;  4KYR A;  3EMU A;  3V0H A;  2I6M A;  2CM3 A;  3EB1 A;  3QCD A;  1JLN A;  1C83 A;  2HY3 A;  1PXH A;  2H4G A;  3F81 A;  3O4S A;  4OHI A;  1I9T A;  1A5Y A;  2HNP A;  2PI7 A;  2VEW A;  2P6X A;  2DXP A;  4QAP A;  1T48 A;  2B07 A;  5BZZ A;  4ZI4 A;  1Q6P A;  4S0G A;  1JF7 A;  2C7S A;  4BJO A;  4D3P A;  4GE2 A;  4GS0 A;  1Q6J A;  3ZM3 A;  3QKP A;  2Y2F A;  5KA4 A;  5KA1 A;  2CNH A;  3GXH A;  2VEY A;  2CMC A;  1I57 A;  1T49 A;  5J8R A;  4AZ1 A;  2PT0 A;  5K9W A;  5IBM A;  2Y96 A;  4I8N A;  2H4K A;  5AWX A;  2CM7 A;  1ONY A;  3QCH A;  2NT2 A;  4QUM A;  2F71 A;  2CJZ A;  4RKK A;  2I4H A;  1LQF A;  1PYN A;  2F6F A;  1PTV A;  5KA8 A; 
#chains in the Genus database with same CATH topology
 3MVN A;  3PS5 A;  4GRY A;  1OHD A;  3QCF A;  3GXG A;  4RHG A;  2JFF A;  2BIJ A;  3N0A A;  1XXV A;  1G1G A;  3I36 A;  2B4O A;  2Y68 A;  3QCJ A;  3V0G A;  3ZM6 A;  1T4J A;  2HC2 A;  2IMG A;  2QBP A;  4NX8 A;  2ESB A;  4HJQ A;  4ICZ A;  3V0D A;  4ZRT A;  1G4U S;  2Y1O A;  2PA5 A;  3N2A A;  3CWE A;  2I6P A;  1U25 A;  3MOZ A;  3V0F A;  4QBW A;  1FPR A;  3ZM2 A;  1RPM A;  3EU0 A;  3RO1 A;  2AM2 A;  1GFY A;  3QCI A;  1C84 A;  1ZCL A;  2PQ5 A;  2I6I A;  4ERC A;  1G7G A;  2RF6 A;  2AZR A;  3PYZ A;  1O5Z A;  3F99 A;  5KA7 A;  1NNY A;  2VTD A;  3ZM0 A;  4D3R A;  2QDC A;  4GE5 A;  5BZX A;  1WAX A;  3F9A A;  5BUG A;  5K22 A;  4R0S A;  1WCH A;  4WU2 A;  2I42 A;  4GRZ A;  1OET A;  4GWF A;  3QCN A;  1OES A;  5KAB A;  1NWL A;  2B4P A;  3QCK A;  3S4O A;  1C85 A;  2QBS A;  1NZ7 A;  3ZM1 A;  1LAR A;  3QCB A;  1C87 A;  4QDI A;  2J16 B;  4Z6B A;  2SHP A;  3D42 A;  2VEV A;  1J6U A;  3UAG A;  2NT7 A;  4QF5 A;  2M3V A;  3S3H A;  1ZZW A;  1GWZ A;  4QUN A;  2E0T A;  2I4E A;  3QCC A;  1YPT A;  2QBQ A;  1NO6 A;  1G4W R;  3LK7 A;  4GFV A;  2P4D A;  1M3G A;  3ZMQ A;  1D5R A;  4CVM A;  4CVK A;  3AWG A;  3B7O A;  3S3E A;  2MBC A;  3MOW A;  2Y67 A;  3RZ2 A;  2BV5 A;  2G59 A;  3ZMP A;  4OHL A;  4DGP A;  1JBW A;  2WTZ A;  1XXP A;  2CM8 A;  2CNE A;  2BZL A;  1Q1M A;  4NND A;  4GE6 A;  3D1O A;  2F6T A;  1YN9 A;  2F00 A;  4QBE A;  5M43 A;  2CNI A;  2CMA A;  1LYV A;  3H2X A;  5KA3 A;  2I6O A;  2F6W A;  2F46 A;  1YGU A;  2Y66 A;  4CVL A;  1BZC A;  2F6Z A;  2HVL A;  4IKC A;  3RGO A;  2ZN7 A;  4QAH A;  5KAD A;  3V0J A;  2CM2 A;  2VOR A;  5HDE A;  2YDU A;  1OHE A;  3EAX A;  1PA1 A;  1GQY A;  3F9B A;  2ZMM A;  3NME A;  2WJP A;  2OC3 A;  1E0D A;  1JBV A;  4RH5 A;  3O4U A;  4D3Q A;  2OUD A;  3O5X A;  3ZV2 A;  4ZN5 A;  4R0T A;  2HNQ A;  2H04 A;  1QXK A;  4KYQ A;  1EEH A;  5LXQ B;  2B4S A;  2UUO A;  4PYH A;  4BUB A;  2CNG A;  2H03 A;  1VHR A;  4Y14 A;  2FJN A;  1OHC A;  2GWO A;  2GCB A;  3QCG A;  2B4U A;  1RXD A;  4JNB A;  4NYH A;  1PH0 A;  2AM1 A;  4B04 A;  4RI5 A;  1YTN A;  4RI4 A;  2J17 A;  2Q05 A;  3V0I A;  4Y2E A;  2B3O A;  2HC1 A;  4JBC A;  4C13 A;  3D9C A;  3QCZ A;  4KI9 A;  1Q6N A;  5KA0 A;  2I75 A;  1ZCK A;  1OEO X;  2C46 A;  5EHP A;  3BLT A;  3MMJ A;  3A5J A;  2BGD A;  4RH9 A;  4JMK A;  3AWE A;  1YZ4 A;  5A5F A;  3A5K A;  3S4E A;  3M4U A;  1ECV A;  1AAX A;  1FQ1 A;  2NLK A;  1C88 A;  4UAG A;  1P15 A;  1BZJ A;  1XBO A;  1G1F A;  5GTJ A;  4YR8 B;  3LJ8 A;  1W78 A;  2PBN A;  1YTS A;  1NWE A;  1U26 A;  1OEU A;  4NWG A;  3D1H A;  5KAA A;  2X5O A;  1FGS A;  1ZC0 A;  1YWF A;  4ZIY A;  3I7Z A;  5K23 A;  2J16 A;  3BLU A;  2CNF A;  2FJM A;  1PA9 A;  4H34 A;  1YTW A;  2JFG A;  1X24 A;  1G1H A;  1I9S A;  2GC5 A;  1EEO A;  2HCM A;  3F41 A;  4TVV A;  1Q6S A;  2NZ6 A;  3S3F A;  2JJD A;  1OEV A;  3SR9 A;  2A3K A;  3D44 A;  3AWF A;  2QEP A;  1XRI A;  4GFU A;  1P31 A;  1NL9 A;  2VEU A;  3RGQ A;  4NWF A;  1EEN A;  4PVG A;  2QCT A;  4OHH A;  3HN7 A;  4OHD A;  1YFO A;  3QCL A;  1MKP A;  1V3A A;  2I4G A;  4C12 A;  3BRH A;  2UUP A;  5K25 A;  5KA9 A;  1R6H A;  2FH7 A;  1WRM A;  2JFH A;  1XM2 A;  2I1Y A;  1ONZ A;  2QCJ A;  2WGP A;  5IBS A;  4WOH A;  2F6Y A;  4H1O A;  3OMH A;  3CM3 A;  2GC6 A;  3V0E A;  1GG4 A;  2HXP A;  1L8K A;  1P3D A;  4RDD A;  4BPC A;  1E8C A;  5KA2 A;  3O3L A;  1PTY A;  1Q6M A;  4YAA A;  3D1Q A;  2VEX A;  4WTY A;  1U24 A;  2UAG A;  1SUG A;  2A8B A;  1KAV A;  5A5E A;  2F6V A;  1W7K A;  2OZ5 A;  3QKQ A;  5MMZ B;  3QCE A;  2HB1 A;  2GCA A;  2NV5 A;  2H4V A;  2OOQ A;  2QBR A;  1FPZ A;  2I3R A;  1PTU A;  4J51 A;  2CFV A;  2QDP A;  4MBB A;  2NTA A;  4HJP A;  2PSZ A;  3BM8 A;  5K24 A;  3O4T A;  1G7F A;  4R30 A;  1L8G A;  2GJT A;  5I6V A;  2I6J A;  3SME A;  2QDM A;  5K9V A;  2G6Z A;  4HRF A;  5EHR A;  1J4X A;  2CMB A;  2I3U A;  2H02 A;  4DGX A;  1QZ0 A;  2GP0 A;  1Q6T A;  3NRS A;  1KAK A;  3I80 A;  2Q47 A;  4OHE A;  1BZH A;  4HV4 A;  3QCM A;  2AHS A;  3U96 A;  2F70 A;  2I5X A;  1PTT A;  4WU3 A;  2B49 A;  3EZZ A;  1YGR A;  2BGE A;  4JMJ A;  2VOS A;  5BX1 A;  3S3K A;  1C86 A;  1OEM X;  5KAC A;  3ZL8 A;  3OLR A;  2R0B A;  4KYR A;  3EMU A;  3V0H A;  2I6M A;  2CM3 A;  3EB1 A;  3QCD A;  1JLN A;  4BUC A;  1C83 A;  2HY3 A;  1PXH A;  2H4G A;  3F81 A;  3O4S A;  2XPC A;  4OHI A;  1I9T A;  1A5Y A;  2HNP A;  2PI7 A;  2VEW A;  2P6X A;  2DXP A;  4QAP A;  1T48 A;  2B07 A;  5BZZ A;  4ZI4 A;  1Q6P A;  2VTE A;  4S0G A;  1JF7 A;  2C7S A;  4BJO A;  4D3P A;  1GQQ A;  1UAG A;  4GE2 A;  4GS0 A;  1Q6J A;  3ZM5 A;  3ZM3 A;  3QKP A;  2Y2F A;  5KA4 A;  5KA1 A;  2CNH A;  3GXH A;  2VEY A;  2CMC A;  1I57 A;  1T49 A;  5J8R A;  4AZ1 A;  2PT0 A;  5K9W A;  5IBM A;  2Y96 A;  4I8N A;  2H4K A;  5AWX A;  2CM7 A;  1ONY A;  3QCH A;  2NT2 A;  4QUM A;  2F71 A;  2CJZ A;  4RKK A;  2I4H A;  1LQF A;  1PYN A;  2F6F A;  2XJA A;  1PTV A;  5KA8 A; 
#chains in the Genus database with same CATH homology
 3PS5 A;  4GRY A;  1OHD A;  3QCF A;  3GXG A;  4RHG A;  2BIJ A;  3N0A A;  1XXV A;  1G1G A;  3I36 A;  2B4O A;  3QCJ A;  3V0G A;  1T4J A;  2HC2 A;  2IMG A;  2QBP A;  4NX8 A;  2ESB A;  4HJQ A;  4ICZ A;  3V0D A;  4ZRT A;  1G4U S;  2PA5 A;  3CWE A;  2I6P A;  1U25 A;  3MOZ A;  3V0F A;  4QBW A;  1FPR A;  3ZM2 A;  1RPM A;  3EU0 A;  3RO1 A;  1GFY A;  3QCI A;  1C84 A;  1ZCL A;  2PQ5 A;  2I6I A;  4ERC A;  1G7G A;  2RF6 A;  2AZR A;  3F99 A;  5KA7 A;  1NNY A;  3ZM0 A;  4D3R A;  2QDC A;  4GE5 A;  5BZX A;  1WAX A;  3F9A A;  5BUG A;  5K22 A;  4R0S A;  1WCH A;  4WU2 A;  2I42 A;  4GRZ A;  1OET A;  4GWF A;  3QCN A;  1OES A;  5KAB A;  1NWL A;  2B4P A;  3QCK A;  3S4O A;  1C85 A;  2QBS A;  1NZ7 A;  3ZM1 A;  1LAR A;  3QCB A;  1C87 A;  2J16 B;  4Z6B A;  2SHP A;  3D42 A;  2VEV A;  2NT7 A;  2M3V A;  3S3H A;  1ZZW A;  1GWZ A;  4QUN A;  2E0T A;  2I4E A;  3QCC A;  1YPT A;  2QBQ A;  1NO6 A;  1G4W R;  4GFV A;  2P4D A;  1M3G A;  3ZMQ A;  1D5R A;  3AWG A;  3B7O A;  3S3E A;  2MBC A;  3MOW A;  3RZ2 A;  2BV5 A;  2G59 A;  3ZMP A;  4OHL A;  4DGP A;  1XXP A;  2CM8 A;  2CNE A;  2BZL A;  1Q1M A;  4NND A;  4GE6 A;  3D1O A;  2F6T A;  1YN9 A;  4QBE A;  5M43 A;  2CNI A;  2CMA A;  1LYV A;  3H2X A;  5KA3 A;  2I6O A;  2F6W A;  2F46 A;  1YGU A;  1BZC A;  2F6Z A;  2HVL A;  4IKC A;  3RGO A;  2ZN7 A;  4QAH A;  5KAD A;  3V0J A;  2CM2 A;  5HDE A;  2YDU A;  1OHE A;  3EAX A;  1PA1 A;  3F9B A;  2ZMM A;  3NME A;  2OC3 A;  4RH5 A;  3O4U A;  4D3Q A;  2OUD A;  3O5X A;  3ZV2 A;  4ZN5 A;  4R0T A;  2HNQ A;  2H04 A;  1QXK A;  4KYQ A;  5LXQ B;  2B4S A;  4PYH A;  2CNG A;  2H03 A;  1VHR A;  4Y14 A;  2FJN A;  1OHC A;  2GWO A;  3QCG A;  2B4U A;  1RXD A;  4JNB A;  4NYH A;  1PH0 A;  4B04 A;  4RI5 A;  1YTN A;  4RI4 A;  2J17 A;  2Q05 A;  3V0I A;  4Y2E A;  2B3O A;  2HC1 A;  4JBC A;  3D9C A;  4KI9 A;  1Q6N A;  5KA0 A;  2I75 A;  1ZCK A;  1OEO X;  2C46 A;  5EHP A;  3BLT A;  3MMJ A;  3A5J A;  2BGD A;  4RH9 A;  4JMK A;  3AWE A;  1YZ4 A;  3A5K A;  3S4E A;  3M4U A;  1ECV A;  1AAX A;  1FQ1 A;  2NLK A;  1C88 A;  1P15 A;  1BZJ A;  1XBO A;  1G1F A;  5GTJ A;  4YR8 B;  3LJ8 A;  2PBN A;  1YTS A;  1NWE A;  1U26 A;  1OEU A;  4NWG A;  3D1H A;  5KAA A;  1ZC0 A;  1YWF A;  3I7Z A;  5K23 A;  2J16 A;  3BLU A;  2CNF A;  2FJM A;  1PA9 A;  4H34 A;  1YTW A;  1X24 A;  1G1H A;  1I9S A;  1EEO A;  2HCM A;  3F41 A;  4TVV A;  1Q6S A;  2NZ6 A;  3S3F A;  2JJD A;  1OEV A;  3SR9 A;  2A3K A;  3D44 A;  3AWF A;  2QEP A;  1XRI A;  4GFU A;  1NL9 A;  2VEU A;  3RGQ A;  4NWF A;  1EEN A;  4PVG A;  2QCT A;  4OHH A;  4OHD A;  1YFO A;  3QCL A;  1MKP A;  1V3A A;  2I4G A;  3BRH A;  5K25 A;  5KA9 A;  1R6H A;  2FH7 A;  1WRM A;  1XM2 A;  2I1Y A;  1ONZ A;  2QCJ A;  2WGP A;  5IBS A;  4WOH A;  2F6Y A;  4H1O A;  3OMH A;  3CM3 A;  3V0E A;  2HXP A;  1L8K A;  4RDD A;  4BPC A;  5KA2 A;  3O3L A;  1PTY A;  1Q6M A;  4YAA A;  3D1Q A;  2VEX A;  4WTY A;  1U24 A;  1SUG A;  2A8B A;  1KAV A;  2F6V A;  2OZ5 A;  3QKQ A;  5MMZ B;  3QCE A;  2HB1 A;  2NV5 A;  2H4V A;  2OOQ A;  2QBR A;  1FPZ A;  2I3R A;  1PTU A;  4J51 A;  2CFV A;  2QDP A;  4MBB A;  2NTA A;  4HJP A;  2PSZ A;  3BM8 A;  5K24 A;  3O4T A;  1G7F A;  4R30 A;  1L8G A;  2GJT A;  5I6V A;  2I6J A;  3SME A;  2QDM A;  5K9V A;  2G6Z A;  4HRF A;  5EHR A;  1J4X A;  2CMB A;  2I3U A;  2H02 A;  4DGX A;  1QZ0 A;  2GP0 A;  1Q6T A;  1KAK A;  3I80 A;  2Q47 A;  4OHE A;  1BZH A;  3QCM A;  2AHS A;  3U96 A;  2F70 A;  2I5X A;  1PTT A;  4WU3 A;  2B49 A;  3EZZ A;  1YGR A;  2BGE A;  4JMJ A;  5BX1 A;  3S3K A;  1C86 A;  1OEM X;  5KAC A;  3OLR A;  2R0B A;  4KYR A;  3EMU A;  3V0H A;  2I6M A;  2CM3 A;  3EB1 A;  3QCD A;  1JLN A;  1C83 A;  2HY3 A;  1PXH A;  2H4G A;  3F81 A;  3O4S A;  4OHI A;  1I9T A;  1A5Y A;  2HNP A;  2PI7 A;  2VEW A;  2P6X A;  2DXP A;  4QAP A;  1T48 A;  2B07 A;  5BZZ A;  4ZI4 A;  1Q6P A;  4S0G A;  1JF7 A;  2C7S A;  4BJO A;  4D3P A;  4GE2 A;  4GS0 A;  1Q6J A;  3ZM3 A;  3QKP A;  2Y2F A;  5KA4 A;  5KA1 A;  2CNH A;  3GXH A;  2VEY A;  2CMC A;  1I57 A;  1T49 A;  5J8R A;  4AZ1 A;  2PT0 A;  5K9W A;  5IBM A;  2Y96 A;  4I8N A;  2H4K A;  5AWX A;  2CM7 A;  1ONY A;  3QCH A;  2NT2 A;  4QUM A;  2F71 A;  2CJZ A;  4RKK A;  2I4H A;  1LQF A;  1PYN A;  2F6F A;  1PTV A;  5KA8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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