2FF6G

Crystal structure of gelsolin domain 1:ciboulot domain 2 hybrid in complex with actin
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
125
structure length
125
Chain Sequence
EHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Structural Basis of Actin Interaction with Multiple WH2/beta-Thymosin Motif-Containing Proteins
pubmed doi rcsb
molecule tags Structural protein/contractile protein
source organism Homo sapiens
molecule keywords Gelsolin
total genus 39
structure length 125
sequence length 125
ec nomenclature
pdb deposition date 2005-12-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2ff6G00
5HVKB 2LXXA 1T2LA 4KEFA 5KYUA 1AK7A 2LLFA 4BEX1 1T44G 1M2VA 1Q8GA 5KYXB 2NUPA 3EGDA 3A5LS 2HD7A 5HVKD 1VFQA 1COFA 3FFKA 1CNUA 2LJ8A 4LIZA 1DEJS 1AHQA 3EGXA 2FGHA 2VILA 4PKGG 3TU5B 4JD2H 2MOTA 1TVJA 2QTVA 5KYYB 2XFAA 1X67A 2KVKA 1PD0A 4Z94G 3EFOA 1YVNG 2VIKA 5IVUA 4S10C 2MP4A 2MV2A 2FH4A 3EG9A 3CIPG 2I2QA 3A5NS 1RGIG 1J72A 3DAWB 2NUTB 2W0IA 4CBXG 1NM1G 1M4JA 1SVRA 2FH2A 1SVQA 2XF1A 3CJBG 1V6FA 5KYUB 5KYWA 1M2VB 1T3YA 1TMWA 1M2OA 2NUPB 4CBWG 5A1MA 3EH1A 2FF3A 1VKKA 1AK6A 3EGDB 1NPHA 1F7SA 1PCXA 3FG7A 1ESVS 5FAFA 1EQYS 1T3XA 1SVYA 1WM4A 2FF6G 1P8ZG 1C0GS 3CJCG 5KYXA 1KCQA 5L6WC 1HQZ1 1NLVG 3EH2A 5KYNA 2FH1A 3EFOB 5FAEA 3A5MS 1NMDG 2FH3A 3EG9B 1YAGG 3CI5G 1H1VG 1D4XG 1MDUA 1P8XA 2VACA 4PKIG 1C0FS 4PKHB 4KEEA 5KYYA 1D0NA 3FFNA 3EGXB 1PD1A 5KYWB 2L72A 3L50A 1QPVA 4CBUG 3A5OS 5DD2A 1JHWA 3FG6A 2D8BA 3Q2BA 1UDMA 1Q8XA 1WNJA 2NUTA 1CFYA 1WFSA 4KEDA
chains in the Genus database with same CATH superfamily
5HVKB 2LXXA 1T2LA 4KEFA 5KYUA 1AK7A 2LLFA 4BEX1 1T44G 1M2VA 1Q8GA 5KYXB 2NUPA 3EGDA 3A5LS 2HD7A 5HVKD 1VFQA 1COFA 3FFKA 1CNUA 2LJ8A 4LIZA 1DEJS 1AHQA 3EGXA 2FGHA 2VILA 4PKGG 3TU5B 4JD2H 2MOTA 1TVJA 2QTVA 5KYYB 2XFAA 1X67A 2KVKA 1PD0A 4Z94G 3EFOA 1YVNG 2VIKA 5IVUA 4S10C 2MP4A 2MV2A 2FH4A 3EG9A 3CIPG 2I2QA 3A5NS 1RGIG 1J72A 3DAWB 2NUTB 2W0IA 4CBXG 1NM1G 1M4JA 1SVRA 2FH2A 1SVQA 2XF1A 3CJBG 1V6FA 5KYUB 5KYWA 1M2VB 1T3YA 1TMWA 1M2OA 2NUPB 4CBWG 5A1MA 3EH1A 2FF3A 1VKKA 1AK6A 3EGDB 1NPHA 1F7SA 1PCXA 3FG7A 1ESVS 5FAFA 1EQYS 1T3XA 1SVYA 1WM4A 2FF6G 1P8ZG 1C0GS 3CJCG 5KYXA 1KCQA 5L6WC 1HQZ1 1NLVG 3EH2A 5KYNA 2FH1A 3EFOB 5FAEA 3A5MS 1NMDG 2FH3A 3EG9B 1YAGG 3CI5G 1H1VG 3DA7A 1D4XG 1MDUA 1P8XA 2VACA 4PKIG 1C0FS 4PKHB 4KEEA 5KYYA 1D0NA 3FFNA 3EGXB 1PD1A 5KYWB 2L72A 3L50A 1QPVA 4CBUG 3A5OS 5DD2A 1JHWA 3FG6A 2D8BA 3Q2BA 1UDMA 1Q8XA 1WNJA 2NUTA 1CFYA 1WFSA 4KEDA
chains in the Genus database with same CATH topology
5HVKB 2LXXA 1T2LA 4KEFA 5KYUA 1AK7A 2LLFA 4BEX1 1T44G 1M2VA 1Q8GA 5KYXB 2NUPA 3EGDA 3A5LS 2HD7A 5HVKD 1VFQA 1COFA 3FFKA 1CNUA 2LJ8A 4LIZA 1DEJS 1AHQA 3EGXA 2FGHA 2VILA 4PKGG 3TU5B 4JD2H 2MOTA 1TVJA 2QTVA 5KYYB 2XFAA 1X67A 2KVKA 1PD0A 4Z94G 3EFOA 1YVNG 2VIKA 5IVUA 4S10C 2MP4A 2MV2A 2FH4A 3EG9A 3CIPG 2I2QA 3A5NS 1RGIG 1J72A 3DAWB 2NUTB 2W0IA 4CBXG 1NM1G 1M4JA 1SVRA 2FH2A 1SVQA 2XF1A 3CJBG 1V6FA 5KYUB 5KYWA 1M2VB 1T3YA 1TMWA 1M2OA 2NUPB 4CBWG 5A1MA 3EH1A 2FF3A 1VKKA 1AK6A 3EGDB 1NPHA 1F7SA 1PCXA 3FG7A 1ESVS 5FAFA 1EQYS 1T3XA 1SVYA 1WM4A 2FF6G 1P8ZG 1C0GS 3CJCG 5KYXA 1KCQA 5L6WC 1HQZ1 1NLVG 3EH2A 5KYNA 2FH1A 3EFOB 5FAEA 3A5MS 1NMDG 2FH3A 3EG9B 1YAGG 3CI5G 1H1VG 3DA7A 1D4XG 1MDUA 1P8XA 2VACA 4PKIG 1C0FS 4PKHB 4KEEA 5KYYA 1D0NA 3FFNA 3EGXB 1PD1A 5KYWB 2L72A 3L50A 1QPVA 4CBUG 3A5OS 5DD2A 1JHWA 3FG6A 2D8BA 3Q2BA 1UDMA 1Q8XA 1WNJA 2NUTA 1CFYA 1WFSA 4KEDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HVK B;  2LXX A;  1T2L A;  4KEF A;  5KYU A;  1AK7 A;  2LLF A;  4BEX 1;  1T44 G;  1M2V A;  1Q8G A;  5KYX B;  2NUP A;  3EGD A;  3A5L S;  2HD7 A;  5HVK D;  1VFQ A;  1COF A;  3FFK A;  1CNU A;  2LJ8 A;  4LIZ A;  1DEJ S;  1AHQ A;  3EGX A;  2FGH A;  2VIL A;  4PKG G;  3TU5 B;  4JD2 H;  2MOT A;  1TVJ A;  2QTV A;  5KYY B;  2XFA A;  1X67 A;  2KVK A;  1PD0 A;  4Z94 G;  3EFO A;  1YVN G;  2VIK A;  5IVU A;  4S10 C;  2MP4 A;  2MV2 A;  2FH4 A;  3EG9 A;  3CIP G;  2I2Q A;  3A5N S;  1RGI G;  1J72 A;  3DAW B;  2NUT B;  2W0I A;  4CBX G;  1NM1 G;  1M4J A;  1SVR A;  2FH2 A;  1SVQ A;  2XF1 A;  3CJB G;  1V6F A;  5KYU B;  5KYW A;  1M2V B;  1T3Y A;  1TMW A;  1M2O A;  2NUP B;  4CBW G;  5A1M A;  3EH1 A;  2FF3 A;  1VKK A;  1AK6 A;  3EGD B;  1NPH A;  1F7S A;  1PCX A;  3FG7 A;  1ESV S;  5FAF A;  1EQY S;  1T3X A;  1SVY A;  1WM4 A;  2FF6 G;  1P8Z G;  1C0G S;  3CJC G;  5KYX A;  1KCQ A;  5L6W C;  1HQZ 1;  1NLV G;  3EH2 A;  5KYN A;  2FH1 A;  3EFO B;  5FAE A;  3A5M S;  1NMD G;  2FH3 A;  3EG9 B;  1YAG G;  3CI5 G;  1H1V G;  1D4X G;  1MDU A;  1P8X A;  2VAC A;  4PKI G;  1C0F S;  4PKH B;  4KEE A;  5KYY A;  1D0N A;  3FFN A;  3EGX B;  1PD1 A;  5KYW B;  2L72 A;  3L50 A;  1QPV A;  4CBU G;  3A5O S;  5DD2 A;  1JHW A;  3FG6 A;  2D8B A;  3Q2B A;  1UDM A;  1Q8X A;  1WNJ A;  2NUT A;  1CFY A;  1WFS A;  4KED A; 
#chains in the Genus database with same CATH topology
 5HVK B;  2LXX A;  1T2L A;  4KEF A;  5KYU A;  1AK7 A;  2LLF A;  4BEX 1;  1T44 G;  1M2V A;  1Q8G A;  5KYX B;  2NUP A;  3EGD A;  3A5L S;  2HD7 A;  5HVK D;  1VFQ A;  1COF A;  3FFK A;  1CNU A;  2LJ8 A;  4LIZ A;  1DEJ S;  1AHQ A;  3EGX A;  2FGH A;  2VIL A;  4PKG G;  3TU5 B;  4JD2 H;  2MOT A;  1TVJ A;  2QTV A;  5KYY B;  2XFA A;  1X67 A;  2KVK A;  1PD0 A;  4Z94 G;  3EFO A;  1YVN G;  2VIK A;  5IVU A;  4S10 C;  2MP4 A;  2MV2 A;  2FH4 A;  3EG9 A;  3CIP G;  2I2Q A;  3A5N S;  1RGI G;  1J72 A;  3DAW B;  2NUT B;  2W0I A;  4CBX G;  1NM1 G;  1M4J A;  1SVR A;  2FH2 A;  1SVQ A;  2XF1 A;  3CJB G;  1V6F A;  5KYU B;  5KYW A;  1M2V B;  1T3Y A;  1TMW A;  1M2O A;  2NUP B;  4CBW G;  5A1M A;  3EH1 A;  2FF3 A;  1VKK A;  1AK6 A;  3EGD B;  1NPH A;  1F7S A;  1PCX A;  3FG7 A;  1ESV S;  5FAF A;  1EQY S;  1T3X A;  1SVY A;  1WM4 A;  2FF6 G;  1P8Z G;  1C0G S;  3CJC G;  5KYX A;  1KCQ A;  5L6W C;  1HQZ 1;  1NLV G;  3EH2 A;  5KYN A;  2FH1 A;  3EFO B;  5FAE A;  3A5M S;  1NMD G;  2FH3 A;  3EG9 B;  1YAG G;  3CI5 G;  1H1V G;  3DA7 A;  1D4X G;  1MDU A;  1P8X A;  2VAC A;  4PKI G;  1C0F S;  4PKH B;  4KEE A;  5KYY A;  1D0N A;  3FFN A;  3EGX B;  1PD1 A;  5KYW B;  2L72 A;  3L50 A;  1QPV A;  4CBU G;  3A5O S;  5DD2 A;  1JHW A;  3FG6 A;  2D8B A;  3Q2B A;  1UDM A;  1Q8X A;  1WNJ A;  2NUT A;  1CFY A;  1WFS A;  4KED A; 
#chains in the Genus database with same CATH homology
 5HVK B;  2LXX A;  1T2L A;  4KEF A;  5KYU A;  1AK7 A;  2LLF A;  4BEX 1;  1T44 G;  1M2V A;  1Q8G A;  5KYX B;  2NUP A;  3EGD A;  3A5L S;  2HD7 A;  5HVK D;  1VFQ A;  1COF A;  3FFK A;  1CNU A;  2LJ8 A;  4LIZ A;  1DEJ S;  1AHQ A;  3EGX A;  2FGH A;  2VIL A;  4PKG G;  3TU5 B;  4JD2 H;  2MOT A;  1TVJ A;  2QTV A;  5KYY B;  2XFA A;  1X67 A;  2KVK A;  1PD0 A;  4Z94 G;  3EFO A;  1YVN G;  2VIK A;  5IVU A;  4S10 C;  2MP4 A;  2MV2 A;  2FH4 A;  3EG9 A;  3CIP G;  2I2Q A;  3A5N S;  1RGI G;  1J72 A;  3DAW B;  2NUT B;  2W0I A;  4CBX G;  1NM1 G;  1M4J A;  1SVR A;  2FH2 A;  1SVQ A;  2XF1 A;  3CJB G;  1V6F A;  5KYU B;  5KYW A;  1M2V B;  1T3Y A;  1TMW A;  1M2O A;  2NUP B;  4CBW G;  5A1M A;  3EH1 A;  2FF3 A;  1VKK A;  1AK6 A;  3EGD B;  1NPH A;  1F7S A;  1PCX A;  3FG7 A;  1ESV S;  5FAF A;  1EQY S;  1T3X A;  1SVY A;  1WM4 A;  2FF6 G;  1P8Z G;  1C0G S;  3CJC G;  5KYX A;  1KCQ A;  5L6W C;  1HQZ 1;  1NLV G;  3EH2 A;  5KYN A;  2FH1 A;  3EFO B;  5FAE A;  3A5M S;  1NMD G;  2FH3 A;  3EG9 B;  1YAG G;  3CI5 G;  1H1V G;  3DA7 A;  1D4X G;  1MDU A;  1P8X A;  2VAC A;  4PKI G;  1C0F S;  4PKH B;  4KEE A;  5KYY A;  1D0N A;  3FFN A;  3EGX B;  1PD1 A;  5KYW B;  2L72 A;  3L50 A;  1QPV A;  4CBU G;  3A5O S;  5DD2 A;  1JHW A;  3FG6 A;  2D8B A;  3Q2B A;  1UDM A;  1Q8X A;  1WNJ A;  2NUT A;  1CFY A;  1WFS A;  4KED A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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