2FH4A

C-terminal half of gelsolin soaked in egta at ph 8
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
330
structure length
307
Chain Sequence
MDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMHPPRLFACEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDTPITVVKQGFEPPSFVGWFLGWDDDYW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Calcium ion exchange in crystalline gelsolin
pubmed doi rcsb
molecule tags Contractile protein
source organism Homo sapiens
molecule keywords Gelsolin
total genus 81
structure length 307
sequence length 330
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2005-12-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2fh4A01
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2fh4A03
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2fh4A02
4CBWG 3EG9B 1ESVS 3CJBG 5DD2A 1T3YA 1P8XA 5KYXA 1AK6A 1CNUA 1T2LA 1YAGG 5KYXB 3EH2A 3CIPG 1T3XA 1Q8XA 2NUTA 5KYYA 5L6WC 2LXXA 2NUTB 5KYYB 1NMDG 2NUPA 1NM1G 3FFKA 4PKGG 4Z94G 3A5MS 5IVUA 2MV2A 1V6FA 1F7SA 2HD7A 2L72A 2XF1A 4CBXG 1WNJA 2D8BA 1HQZ1 1H1VG 5KYNA 4KEDA 1M4JA 2FH3A 1RGIG 2FH4A 2QTVA 4PKIG 3Q2BA 2LLFA 1MDUA 2VIKA 4BEX1 1M2VA 3FFNA 3EGXA 4KEFA 1NLVG 1NPHA 1VKKA 2FH2A 1COFA 1AHQA 5A1MA 2FF6G 5KYWA 1PD0A 1QPVA 4LIZA 2NUPB 1EQYS 4CBUG 5FAEA 2FH1A 5KYUA 5HVKD 1AK7A 5KYUB 1DEJS 3TU5B 1D4XG 1PCXA 3FG6A 3A5NS 3CJCG 1X67A 2VILA 3A5OS 1M2VB 1VFQA 3FG7A 3EH1A 3EGXB 1CFYA 1C0GS 1TVJA 1C0FS 3CI5G 4S10C 2FF3A 1WM4A 3A5LS 2MP4A 1Q8GA 1J72A 2KVKA 1WFSA 1YVNG 2W0IA 3L50A 5KYWB 1TMWA 1P8ZG 1UDMA 1JHWA 2VACA 1KCQA 4PKHB 1T44G 2XFAA 1PD1A 2MOTA 2I2QA 1SVQA 4JD2H 3DAWB 1SVRA 1D0NA 1M2OA 4KEEA 2LJ8A 3EGDA 3EFOA 1SVYA 5FAFA 5HVKB 3EGDB 3EG9A 2FGHA 3EFOB
chains in the Genus database with same CATH superfamily
4CBWG 3EG9B 1ESVS 3CJBG 5DD2A 1T3YA 1P8XA 5KYXA 1AK6A 1CNUA 1T2LA 1YAGG 3DA7A 5KYXB 3EH2A 3CIPG 1T3XA 1Q8XA 2NUTA 5KYYA 5L6WC 2LXXA 2NUTB 5KYYB 1NMDG 2NUPA 1NM1G 3FFKA 4PKGG 4Z94G 3A5MS 5IVUA 2MV2A 1V6FA 1F7SA 2HD7A 2L72A 2XF1A 4CBXG 1WNJA 2D8BA 1HQZ1 1H1VG 5KYNA 4KEDA 1M4JA 2FH3A 1RGIG 2FH4A 2QTVA 4PKIG 3Q2BA 2LLFA 1MDUA 2VIKA 4BEX1 1M2VA 3FFNA 3EGXA 4KEFA 1NLVG 1NPHA 1VKKA 2FH2A 1COFA 1AHQA 5A1MA 2FF6G 5KYWA 1PD0A 1QPVA 4LIZA 2NUPB 1EQYS 4CBUG 5FAEA 2FH1A 5KYUA 5HVKD 1AK7A 5KYUB 1DEJS 3TU5B 1D4XG 1PCXA 3FG6A 3A5NS 3CJCG 1X67A 2VILA 3A5OS 1M2VB 1VFQA 3FG7A 3EH1A 3EGXB 1CFYA 1C0GS 1TVJA 1C0FS 3CI5G 4S10C 2FF3A 1WM4A 3A5LS 2MP4A 1Q8GA 1J72A 2KVKA 1WFSA 1YVNG 2W0IA 3L50A 5KYWB 1TMWA 1P8ZG 1UDMA 1JHWA 2VACA 1KCQA 4PKHB 1T44G 2XFAA 1PD1A 2MOTA 2I2QA 1SVQA 4JD2H 3DAWB 1SVRA 1D0NA 1M2OA 4KEEA 2LJ8A 3EGDA 3EFOA 1SVYA 5FAFA 5HVKB 3EGDB 3EG9A 2FGHA 3EFOB
chains in the Genus database with same CATH topology
4CBWG 3EG9B 1ESVS 3CJBG 5DD2A 1T3YA 1P8XA 5KYXA 1AK6A 1CNUA 1T2LA 1YAGG 3DA7A 5KYXB 3EH2A 3CIPG 1T3XA 1Q8XA 2NUTA 5KYYA 5L6WC 2LXXA 2NUTB 5KYYB 1NMDG 2NUPA 1NM1G 3FFKA 4PKGG 4Z94G 3A5MS 5IVUA 2MV2A 1V6FA 1F7SA 2HD7A 2L72A 2XF1A 4CBXG 1WNJA 2D8BA 1HQZ1 1H1VG 5KYNA 4KEDA 1M4JA 2FH3A 1RGIG 2FH4A 2QTVA 4PKIG 3Q2BA 2LLFA 1MDUA 2VIKA 4BEX1 1M2VA 3FFNA 3EGXA 4KEFA 1NLVG 1NPHA 1VKKA 2FH2A 1COFA 1AHQA 5A1MA 2FF6G 5KYWA 1PD0A 1QPVA 4LIZA 2NUPB 1EQYS 4CBUG 5FAEA 2FH1A 5KYUA 5HVKD 1AK7A 5KYUB 1DEJS 3TU5B 1D4XG 1PCXA 3FG6A 3A5NS 3CJCG 1X67A 2VILA 3A5OS 1M2VB 1VFQA 3FG7A 3EH1A 3EGXB 1CFYA 1C0GS 1TVJA 1C0FS 3CI5G 4S10C 2FF3A 1WM4A 3A5LS 2MP4A 1Q8GA 1J72A 2KVKA 1WFSA 1YVNG 2W0IA 3L50A 5KYWB 1TMWA 1P8ZG 1UDMA 1JHWA 2VACA 1KCQA 4PKHB 1T44G 2XFAA 1PD1A 2MOTA 2I2QA 1SVQA 4JD2H 3DAWB 1SVRA 1D0NA 1M2OA 4KEEA 2LJ8A 3EGDA 3EFOA 1SVYA 5FAFA 5HVKB 3EGDB 3EG9A 2FGHA 3EFOB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CBW G;  3EG9 B;  1ESV S;  3CJB G;  5DD2 A;  1T3Y A;  1P8X A;  5KYX A;  1AK6 A;  1CNU A;  1T2L A;  1YAG G;  5KYX B;  3EH2 A;  3CIP G;  1T3X A;  1Q8X A;  2NUT A;  5KYY A;  5L6W C;  2LXX A;  2NUT B;  5KYY B;  1NMD G;  2NUP A;  1NM1 G;  3FFK A;  4PKG G;  4Z94 G;  3A5M S;  5IVU A;  2MV2 A;  1V6F A;  1F7S A;  2HD7 A;  2L72 A;  2XF1 A;  4CBX G;  1WNJ A;  2D8B A;  1HQZ 1;  1H1V G;  5KYN A;  4KED A;  1M4J A;  2FH3 A;  1RGI G;  2FH4 A;  2QTV A;  4PKI G;  3Q2B A;  2LLF A;  1MDU A;  2VIK A;  4BEX 1;  1M2V A;  3FFN A;  3EGX A;  4KEF A;  1NLV G;  1NPH A;  1VKK A;  2FH2 A;  1COF A;  1AHQ A;  5A1M A;  2FF6 G;  5KYW A;  1PD0 A;  1QPV A;  4LIZ A;  2NUP B;  1EQY S;  4CBU G;  5FAE A;  2FH1 A;  5KYU A;  5HVK D;  1AK7 A;  5KYU B;  1DEJ S;  3TU5 B;  1D4X G;  1PCX A;  3FG6 A;  3A5N S;  3CJC G;  1X67 A;  2VIL A;  3A5O S;  1M2V B;  1VFQ A;  3FG7 A;  3EH1 A;  3EGX B;  1CFY A;  1C0G S;  1TVJ A;  1C0F S;  3CI5 G;  4S10 C;  2FF3 A;  1WM4 A;  3A5L S;  2MP4 A;  1Q8G A;  1J72 A;  2KVK A;  1WFS A;  1YVN G;  2W0I A;  3L50 A;  5KYW B;  1TMW A;  1P8Z G;  1UDM A;  1JHW A;  2VAC A;  1KCQ A;  4PKH B;  1T44 G;  2XFA A;  1PD1 A;  2MOT A;  2I2Q A;  1SVQ A;  4JD2 H;  3DAW B;  1SVR A;  1D0N A;  1M2O A;  4KEE A;  2LJ8 A;  3EGD A;  3EFO A;  1SVY A;  5FAF A;  5HVK B;  3EGD B;  3EG9 A;  2FGH A;  3EFO B; 
#chains in the Genus database with same CATH topology
 4CBW G;  3EG9 B;  1ESV S;  3CJB G;  5DD2 A;  1T3Y A;  1P8X A;  5KYX A;  1AK6 A;  1CNU A;  1T2L A;  1YAG G;  3DA7 A;  5KYX B;  3EH2 A;  3CIP G;  1T3X A;  1Q8X A;  2NUT A;  5KYY A;  5L6W C;  2LXX A;  2NUT B;  5KYY B;  1NMD G;  2NUP A;  1NM1 G;  3FFK A;  4PKG G;  4Z94 G;  3A5M S;  5IVU A;  2MV2 A;  1V6F A;  1F7S A;  2HD7 A;  2L72 A;  2XF1 A;  4CBX G;  1WNJ A;  2D8B A;  1HQZ 1;  1H1V G;  5KYN A;  4KED A;  1M4J A;  2FH3 A;  1RGI G;  2FH4 A;  2QTV A;  4PKI G;  3Q2B A;  2LLF A;  1MDU A;  2VIK A;  4BEX 1;  1M2V A;  3FFN A;  3EGX A;  4KEF A;  1NLV G;  1NPH A;  1VKK A;  2FH2 A;  1COF A;  1AHQ A;  5A1M A;  2FF6 G;  5KYW A;  1PD0 A;  1QPV A;  4LIZ A;  2NUP B;  1EQY S;  4CBU G;  5FAE A;  2FH1 A;  5KYU A;  5HVK D;  1AK7 A;  5KYU B;  1DEJ S;  3TU5 B;  1D4X G;  1PCX A;  3FG6 A;  3A5N S;  3CJC G;  1X67 A;  2VIL A;  3A5O S;  1M2V B;  1VFQ A;  3FG7 A;  3EH1 A;  3EGX B;  1CFY A;  1C0G S;  1TVJ A;  1C0F S;  3CI5 G;  4S10 C;  2FF3 A;  1WM4 A;  3A5L S;  2MP4 A;  1Q8G A;  1J72 A;  2KVK A;  1WFS A;  1YVN G;  2W0I A;  3L50 A;  5KYW B;  1TMW A;  1P8Z G;  1UDM A;  1JHW A;  2VAC A;  1KCQ A;  4PKH B;  1T44 G;  2XFA A;  1PD1 A;  2MOT A;  2I2Q A;  1SVQ A;  4JD2 H;  3DAW B;  1SVR A;  1D0N A;  1M2O A;  4KEE A;  2LJ8 A;  3EGD A;  3EFO A;  1SVY A;  5FAF A;  5HVK B;  3EGD B;  3EG9 A;  2FGH A;  3EFO B; 
#chains in the Genus database with same CATH homology
 4CBW G;  3EG9 B;  1ESV S;  3CJB G;  5DD2 A;  1T3Y A;  1P8X A;  5KYX A;  1AK6 A;  1CNU A;  1T2L A;  1YAG G;  3DA7 A;  5KYX B;  3EH2 A;  3CIP G;  1T3X A;  1Q8X A;  2NUT A;  5KYY A;  5L6W C;  2LXX A;  2NUT B;  5KYY B;  1NMD G;  2NUP A;  1NM1 G;  3FFK A;  4PKG G;  4Z94 G;  3A5M S;  5IVU A;  2MV2 A;  1V6F A;  1F7S A;  2HD7 A;  2L72 A;  2XF1 A;  4CBX G;  1WNJ A;  2D8B A;  1HQZ 1;  1H1V G;  5KYN A;  4KED A;  1M4J A;  2FH3 A;  1RGI G;  2FH4 A;  2QTV A;  4PKI G;  3Q2B A;  2LLF A;  1MDU A;  2VIK A;  4BEX 1;  1M2V A;  3FFN A;  3EGX A;  4KEF A;  1NLV G;  1NPH A;  1VKK A;  2FH2 A;  1COF A;  1AHQ A;  5A1M A;  2FF6 G;  5KYW A;  1PD0 A;  1QPV A;  4LIZ A;  2NUP B;  1EQY S;  4CBU G;  5FAE A;  2FH1 A;  5KYU A;  5HVK D;  1AK7 A;  5KYU B;  1DEJ S;  3TU5 B;  1D4X G;  1PCX A;  3FG6 A;  3A5N S;  3CJC G;  1X67 A;  2VIL A;  3A5O S;  1M2V B;  1VFQ A;  3FG7 A;  3EH1 A;  3EGX B;  1CFY A;  1C0G S;  1TVJ A;  1C0F S;  3CI5 G;  4S10 C;  2FF3 A;  1WM4 A;  3A5L S;  2MP4 A;  1Q8G A;  1J72 A;  2KVK A;  1WFS A;  1YVN G;  2W0I A;  3L50 A;  5KYW B;  1TMW A;  1P8Z G;  1UDM A;  1JHW A;  2VAC A;  1KCQ A;  4PKH B;  1T44 G;  2XFA A;  1PD1 A;  2MOT A;  2I2Q A;  1SVQ A;  4JD2 H;  3DAW B;  1SVR A;  1D0N A;  1M2O A;  4KEE A;  2LJ8 A;  3EGD A;  3EFO A;  1SVY A;  5FAF A;  5HVK B;  3EGD B;  3EG9 A;  2FGH A;  3EFO B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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