2FPQA

Crystal structure of botulinum neurotoxin type d light chain
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
426
structure length
413
Chain Sequence
EFMTWPVKDFNYSDPVNDNDILYLRIPQNKLITTPVKAFMITQNIWVIPERFSSDTNPSLSKPPRPTSKYQSYYDPSYLSTDEQKDTFLKGIIKLFKRINERDIGKKLINYLVVGSPFMGDSSTPEDTFDFTRHTTNIAVEKFENGSWKVTNIITPSVLIFGPLPNILDYTASLTQSNPSFEGFGTLSILKVAPEFLLTFSDVGKSIFCMDPVIALMHELTHSLHQLYGINIPSDKRIRPQVSEGFFSQDGPNVQFEELYTFGGLDVEIIPQIERSQLREKALGHYKDIAKRLNNINKTIPSSWISNIDKYKKIFSEKYNFDKDNTGNFVVNIDKFNSLYSDLTNVMSEVVYSSQYNVKNRTHYFSRHYLPVFANILDDNIYTIRDGFNLTNKGFNIENSGQNIERNPALQKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of Botulinum Neurotoxin Type D Light Chain at 1.65 A Resolution: Repercussions for VAMP-2 Substrate Specificity(,).
pubmed doi rcsb
molecule tags Toxin
source organism Clostridium botulinum
molecule keywords BOTULINUM NEUROTOXIN D LIGHT CHAIN
total genus 128
structure length 413
sequence length 426
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2006-01-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2fpqA00
3V0AA 2G7QA 3ZURA 2IMAA 2ETFA 3BONA 3C8BA 1ZKXA 4KTXA 1ZKWA 1ZN3A 1XTFA 1ZL5A 5BQMA 3DDBA 1T3AA 2G7NA 3QW8A 2IMBA 1E1HA 2NP0A 1ZB7A 2ISEA 3V0BB 1T3CA 3BTAA 1ZL6A 3FIEA 4ZJXA 3QIYA 3BOKA 4KS6A 2NZ9A 3FFZA 3ZUQA 3QIZA 1G9AA 3C88A 3QJ0A 1G9BA 1F82A 2IMCA 4EL4A 2A97A 2ISHA 3FIIA 1EPWA 1I1EA 2NYYA 1G9DA 3V0AB 1Z7HA 1YVGA 3VUOA 4J1LA 3C89A 3DS9A 1S0BA 3C8AA 3NF3A 2G7KA 4HEVA 1G9CA 4KUFA 2XHLA 3D3XA 2FPQA 2QN0A 3V0BA 1F31A 3ZUSA 3DSEA 1S0DA 3BOOA 1S0FA 2ILPA 1S0GA 3BWIA 4ELCA 2ISGA 3QIXA 4ZKTB 5BQNA 3DDAA 3DEBA 1S0EA 3QW6A 3QW7A 2W2DA 2G7PA 3QW5A 1XTGA 3K3QB 1S0CA 2A8AA 4EJ5A
chains in the Genus database with same CATH superfamily
3V0AA 2G7QA 3ZURA 2IMAA 2ETFA 3BONA 3C8BA 1ZKXA 4KTXA 1ZKWA 1ZN3A 1XTFA 1ZL5A 4JIXA 5BQMA 3DDBA 1T3AA 4IL3A 2G7NA 3QW8A 2IMBA 1E1HA 2NP0A 1ZB7A 2ISEA 3V0BB 4AW6A 1T3CA 3BTAA 1ZL6A 3FIEA 4ZJXA 3QIYA 3BOKA 4KS6A 2NZ9A 3FFZA 3ZUQA 3QIZA 1G9AA 3C88A 3QJ0A 1G9BA 1F82A 2IMCA 4JIUA 4EL4A 2A97A 2ISHA 3FIIA 1EPWA 1I1EA 2NYYA 1G9DA 2YPTA 3V0AB 1Z7HA 1YVGA 3VUOA 4J1LA 3C89A 3DS9A 1S0BA 3E11A 3C8AA 3NF3A 2G7KA 4HEVA 3CQBA 1G9CA 4KUFA 2XHLA 3D3XA 2FPQA 2QN0A 3V0BA 1F31A 3ZUSA 3DSEA 1S0DA 2EJQA 3BOOA 1S0FA 2ILPA 1S0GA 3BWIA 4ELCA 2ISGA 3QIXA 4ZKTB 5BQNA 3DDAA 3DEBA 1S0EA 3QW6A 3QW7A 4QHFA 2W2DA 2G7PA 3QW5A 1XTGA 3K3QB 1S0CA 2A8AA 4EJ5A
chains in the Genus database with same CATH topology
3V0AA 2G7QA 3ZURA 2IMAA 2ETFA 3BONA 3C8BA 1ZKXA 4KTXA 1ZKWA 1ZN3A 1XTFA 1ZL5A 5BQMA 3DDBA 1T3AA 2G7NA 3QW8A 2IMBA 1E1HA 2NP0A 1ZB7A 2ISEA 3V0BB 1T3CA 3BTAA 1ZL6A 3FIEA 4ZJXA 3QIYA 3BOKA 4KS6A 2NZ9A 3FFZA 3ZUQA 3QIZA 1G9AA 3C88A 3QJ0A 1G9BA 1F82A 2IMCA 4EL4A 2A97A 2ISHA 3FIIA 1EPWA 1I1EA 2NYYA 1G9DA 3V0AB 1Z7HA 1YVGA 3VUOA 4J1LA 3C89A 3DS9A 1S0BA 3C8AA 3NF3A 2G7KA 4HEVA 1G9CA 4KUFA 2XHLA 3D3XA 2FPQA 2QN0A 3V0BA 1F31A 3ZUSA 3DSEA 1S0DA 3BOOA 1S0FA 2ILPA 1S0GA 3BWIA 4ELCA 2ISGA 3QIXA 4ZKTB 5BQNA 3DDAA 3DEBA 1S0EA 3QW6A 3QW7A 2W2DA 2G7PA 3QW5A 1XTGA 3K3QB 1S0CA 2A8AA 4EJ5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3V0A A;  2G7Q A;  3ZUR A;  2IMA A;  2ETF A;  3BON A;  3C8B A;  1ZKX A;  4KTX A;  1ZKW A;  1ZN3 A;  1XTF A;  1ZL5 A;  5BQM A;  3DDB A;  1T3A A;  2G7N A;  3QW8 A;  2IMB A;  1E1H A;  2NP0 A;  1ZB7 A;  2ISE A;  3V0B B;  1T3C A;  3BTA A;  1ZL6 A;  3FIE A;  4ZJX A;  3QIY A;  3BOK A;  4KS6 A;  2NZ9 A;  3FFZ A;  3ZUQ A;  3QIZ A;  1G9A A;  3C88 A;  3QJ0 A;  1G9B A;  1F82 A;  2IMC A;  4EL4 A;  2A97 A;  2ISH A;  3FII A;  1EPW A;  1I1E A;  2NYY A;  1G9D A;  3V0A B;  1Z7H A;  1YVG A;  3VUO A;  4J1L A;  3C89 A;  3DS9 A;  1S0B A;  3C8A A;  3NF3 A;  2G7K A;  4HEV A;  1G9C A;  4KUF A;  2XHL A;  3D3X A;  2FPQ A;  2QN0 A;  3V0B A;  1F31 A;  3ZUS A;  3DSE A;  1S0D A;  3BOO A;  1S0F A;  2ILP A;  1S0G A;  3BWI A;  4ELC A;  2ISG A;  3QIX A;  4ZKT B;  5BQN A;  3DDA A;  3DEB A;  1S0E A;  3QW6 A;  3QW7 A;  2W2D A;  2G7P A;  3QW5 A;  1XTG A;  3K3Q B;  1S0C A;  2A8A A;  4EJ5 A; 
#chains in the Genus database with same CATH topology
 3V0A A;  2G7Q A;  3ZUR A;  2IMA A;  2ETF A;  3BON A;  3C8B A;  1ZKX A;  4KTX A;  1ZKW A;  1ZN3 A;  1XTF A;  1ZL5 A;  4JIX A;  5BQM A;  3DDB A;  1T3A A;  4IL3 A;  2G7N A;  3QW8 A;  2IMB A;  1E1H A;  2NP0 A;  1ZB7 A;  2ISE A;  3V0B B;  4AW6 A;  1T3C A;  3BTA A;  1ZL6 A;  3FIE A;  4ZJX A;  3QIY A;  3BOK A;  4KS6 A;  2NZ9 A;  3FFZ A;  3ZUQ A;  3QIZ A;  1G9A A;  3C88 A;  3QJ0 A;  1G9B A;  1F82 A;  2IMC A;  4JIU A;  4EL4 A;  2A97 A;  2ISH A;  3FII A;  1EPW A;  1I1E A;  2NYY A;  1G9D A;  2YPT A;  3V0A B;  1Z7H A;  1YVG A;  3VUO A;  4J1L A;  3C89 A;  3DS9 A;  1S0B A;  3E11 A;  3C8A A;  3NF3 A;  2G7K A;  4HEV A;  3CQB A;  1G9C A;  4KUF A;  2XHL A;  3D3X A;  2FPQ A;  2QN0 A;  3V0B A;  1F31 A;  3ZUS A;  3DSE A;  1S0D A;  2EJQ A;  3BOO A;  1S0F A;  2ILP A;  1S0G A;  3BWI A;  4ELC A;  2ISG A;  3QIX A;  4ZKT B;  5BQN A;  3DDA A;  3DEB A;  1S0E A;  3QW6 A;  3QW7 A;  4QHF A;  2W2D A;  2G7P A;  3QW5 A;  1XTG A;  3K3Q B;  1S0C A;  2A8A A;  4EJ5 A; 
#chains in the Genus database with same CATH homology
 3V0A A;  2G7Q A;  3ZUR A;  2IMA A;  2ETF A;  3BON A;  3C8B A;  1ZKX A;  4KTX A;  1ZKW A;  1ZN3 A;  1XTF A;  1ZL5 A;  5BQM A;  3DDB A;  1T3A A;  2G7N A;  3QW8 A;  2IMB A;  1E1H A;  2NP0 A;  1ZB7 A;  2ISE A;  3V0B B;  1T3C A;  3BTA A;  1ZL6 A;  3FIE A;  4ZJX A;  3QIY A;  3BOK A;  4KS6 A;  2NZ9 A;  3FFZ A;  3ZUQ A;  3QIZ A;  1G9A A;  3C88 A;  3QJ0 A;  1G9B A;  1F82 A;  2IMC A;  4EL4 A;  2A97 A;  2ISH A;  3FII A;  1EPW A;  1I1E A;  2NYY A;  1G9D A;  3V0A B;  1Z7H A;  1YVG A;  3VUO A;  4J1L A;  3C89 A;  3DS9 A;  1S0B A;  3C8A A;  3NF3 A;  2G7K A;  4HEV A;  1G9C A;  4KUF A;  2XHL A;  3D3X A;  2FPQ A;  2QN0 A;  3V0B A;  1F31 A;  3ZUS A;  3DSE A;  1S0D A;  3BOO A;  1S0F A;  2ILP A;  1S0G A;  3BWI A;  4ELC A;  2ISG A;  3QIX A;  4ZKT B;  5BQN A;  3DDA A;  3DEB A;  1S0E A;  3QW6 A;  3QW7 A;  2W2D A;  2G7P A;  3QW5 A;  1XTG A;  3K3Q B;  1S0C A;  2A8A A;  4EJ5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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