2FUSA

Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site
Total Genus 168
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
168
sequence length
456
structure length
456
Chain Sequence
VRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVNPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTHLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords FUMARASE C
publication title Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolyase
total genus 168
structure length 456
sequence length 456
chains with identical sequence B
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 1997-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 2fusA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2fusA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2fusA02
1J3UA 2FUSA 1EB4A 1Y2MA 1C3UA 2PFMA 3C8TA 5D6BA 2RJSA 1TJWA 2J91A 3GTDA 2O78A 3OCEA 4APBA 1FUPA 4MX2A 1FUQA 4C5RA 3E04A 2QVEA 3TV2A 1HY0A 1JSWA 4FFXA 4V2RA 1Q5NA 2O7BA 3KDYA 4APAA 3NO9A 4NLEA 1AUWA 4ADLA 5EYVA 2YIIA 1RE5A 3OCFA 3RRPA 3CZOA 1K62A 1TJUA 1GK2A 4EFCA 2VD6A 4C5SA 3GZHA 4EEIA 1YFMA 4C6GA 2X75A 2NYNA 2O6YA 1B8FA 4BABA 2NYFA 2QGAB 1FURA 3RD8A 1TJ7A 3QBPA 1TJVA 1XWOA 1YISA 2PTQA 2PTSA 5F92A 1DOFA 1T6JA 1W27A 4FLCA 2RJRA 3BHGA 2O7DA 2O7EA 3R6QA 1GKMA 4ADMA 2O7FA 3UNVA 2PTRA 1KQ7A 1VDKA 1GKJA 1U15A 4BAAA 1C3CA 5EYTA 1YFEA 1HY1A 4CQ5A 1FUOA 3R6YA 3NZ4A 2E9FA 1I0AA 2OHYA 4HGVA 2HVGA 1DCNA 1GK3A 1T6PA 5F91A 3KDZA 3R6VA 4NSLA 4V2QA 5HW2A 4C5UA 1U16A 1K7WA
chains in the Genus database with same CATH superfamily
1XMDA 1J3UA 2FUSA 1EB4A 1Q92A 1C3UA 1T9HA 1Y2MA 2JAUA 4YIKA 3U19A 2JARA 2PFMA 3C8TA 4YIHA 2JAOA 5D6BA 2RJSA 1TJWA 2J91A 3GTDA 2O78A 4WNLA 1XL7A 3OCEA 4APBA 1FUPA 4MX2A 1FUQA 4C5RA 3E04A 2QVEA 2FENA 3TV2A 1HY0A 1JSWA 3F4SA 3CRVA 4MUMA 3CI0K 4FFXA 4V2RA 1Q5NA 2O7BA 3KDYA 4APAA 3NO9A 4NLEA 4E88A 1AUWA 2FELA 1U0LA 4ADLA 1Z4LA 3CRW1 5EYVA 2YIIA 1RE5A 3OCFA 3RRPA 3CZOA 1K62A 1TJUA 4NFLA 1GK2A 4EFCA 2VD6A 4C5SA 3GZHA 4EEIA 1YFMA 4C6GA 2X75A 2NYNA 2O6YA 1B8FA 3BWVA 4BABA 2NYFA 2QGAB 1FURA 3RD8A 4L6AA 1TJ7A 3QBPA 1Z4QA 2I7DA 2D27A 2VSFA 1IW7D 2VL7A 1TJVA 1XWOA 1YISA 2PTQA 1MH9A 2PTSA 3F4RA 5F92A 1Z4JA 1DOFA 1T6JA 1W27A 4FLCA 2RJRA 3BHGA 2O7DA 2O7EA 3R6QA 1GKMA 4ADMA 2O7FA 3UNVA 2PTRA 4A15A 1KQ7A 1VDKA 1XLYA 1GKJA 1U15A 4BAAA 1C3CA 5EYTA 1YFEA 5M0JA 1HY1A 2JAWA 4CQ5A 5H8WA 1FUOA 4L6CA 3R6YA 4IQJM 3NZ4A 2E9FA 3U13A 1I0AA 2OHYA 4HGVA 2HVGA 1Z4IA 1DCNA 4MWOA 1GK3A 1T6PA 1Z4MA 5F91A 4L57A 1Z4PX 3R6VA 2D28C 1XL8A 3KDZA 3F4TA 1XMCA 4NSLA 4V2QA 2YV5A 5HW2A 5M0IA 2RCNA 1Q91A 4C5UA 1U16A 1Z4KA 1K7WA
chains in the Genus database with same CATH topology
1J3UA 2FUSA 1EB4A 1Y2MA 1C3UA 2PFMA 3C8TA 5D6BA 2RJSA 1TJWA 2J91A 3GTDA 2O78A 3OCEA 4APBA 1FUPA 4MX2A 1FUQA 4C5RA 3E04A 2QVEA 3TV2A 1HY0A 1JSWA 4FFXA 4V2RA 1Q5NA 2O7BA 3KDYA 4APAA 3NO9A 4NLEA 1AUWA 4ADLA 5EYVA 2YIIA 1RE5A 3OCFA 3RRPA 3CZOA 1K62A 1TJUA 1GK2A 4EFCA 2VD6A 4C5SA 3GZHA 4EEIA 1YFMA 4C6GA 2X75A 2NYNA 2O6YA 1B8FA 4BABA 2NYFA 2QGAB 1FURA 3RD8A 1TJ7A 3QBPA 1TJVA 1XWOA 1YISA 2PTQA 2PTSA 5F92A 1DOFA 1T6JA 1W27A 4FLCA 2RJRA 3BHGA 2O7DA 2O7EA 3R6QA 1GKMA 4ADMA 2O7FA 3UNVA 2PTRA 1KQ7A 1VDKA 1GKJA 1U15A 4BAAA 1C3CA 5EYTA 1YFEA 1HY1A 4CQ5A 1FUOA 3R6YA 3NZ4A 2E9FA 1I0AA 2OHYA 4HGVA 2HVGA 1DCNA 1GK3A 1T6PA 5F91A 3KDZA 3R6VA 4NSLA 4V2QA 5HW2A 4C5UA 1U16A 1K7WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1J3U A;  2FUS A;  1EB4 A;  1Y2M A;  1C3U A;  2PFM A;  3C8T A;  5D6B A;  2RJS A;  1TJW A;  2J91 A;  3GTD A;  2O78 A;  3OCE A;  4APB A;  1FUP A;  4MX2 A;  1FUQ A;  4C5R A;  3E04 A;  2QVE A;  3TV2 A;  1HY0 A;  1JSW A;  4FFX A;  4V2R A;  1Q5N A;  2O7B A;  3KDY A;  4APA A;  3NO9 A;  4NLE A;  1AUW A;  4ADL A;  5EYV A;  2YII A;  1RE5 A;  3OCF A;  3RRP A;  3CZO A;  1K62 A;  1TJU A;  1GK2 A;  4EFC A;  2VD6 A;  4C5S A;  3GZH A;  4EEI A;  1YFM A;  4C6G A;  2X75 A;  2NYN A;  2O6Y A;  1B8F A;  4BAB A;  2NYF A;  2QGA B;  1FUR A;  3RD8 A;  1TJ7 A;  3QBP A;  1TJV A;  1XWO A;  1YIS A;  2PTQ A;  2PTS A;  5F92 A;  1DOF A;  1T6J A;  1W27 A;  4FLC A;  2RJR A;  3BHG A;  2O7D A;  2O7E A;  3R6Q A;  1GKM A;  4ADM A;  2O7F A;  3UNV A;  2PTR A;  1KQ7 A;  1VDK A;  1GKJ A;  1U15 A;  4BAA A;  1C3C A;  5EYT A;  1YFE A;  1HY1 A;  4CQ5 A;  1FUO A;  3R6Y A;  3NZ4 A;  2E9F A;  1I0A A;  2OHY A;  4HGV A;  2HVG A;  1DCN A;  1GK3 A;  1T6P A;  5F91 A;  3KDZ A;  3R6V A;  4NSL A;  4V2Q A;  5HW2 A;  4C5U A;  1U16 A;  1K7W A; 
#chains in the Genus database with same CATH topology
 1XMD A;  1J3U A;  2FUS A;  1EB4 A;  1Q92 A;  1C3U A;  1T9H A;  1Y2M A;  2JAU A;  4YIK A;  3U19 A;  2JAR A;  2PFM A;  3C8T A;  4YIH A;  2JAO A;  5D6B A;  2RJS A;  1TJW A;  2J91 A;  3GTD A;  2O78 A;  4WNL A;  1XL7 A;  3OCE A;  4APB A;  1FUP A;  4MX2 A;  1FUQ A;  4C5R A;  3E04 A;  2QVE A;  2FEN A;  3TV2 A;  1HY0 A;  1JSW A;  3F4S A;  3CRV A;  4MUM A;  3CI0 K;  4FFX A;  4V2R A;  1Q5N A;  2O7B A;  3KDY A;  4APA A;  3NO9 A;  4NLE A;  4E88 A;  1AUW A;  2FEL A;  1U0L A;  4ADL A;  1Z4L A;  3CRW 1;  5EYV A;  2YII A;  1RE5 A;  3OCF A;  3RRP A;  3CZO A;  1K62 A;  1TJU A;  4NFL A;  1GK2 A;  4EFC A;  2VD6 A;  4C5S A;  3GZH A;  4EEI A;  1YFM A;  4C6G A;  2X75 A;  2NYN A;  2O6Y A;  1B8F A;  3BWV A;  4BAB A;  2NYF A;  2QGA B;  1FUR A;  3RD8 A;  4L6A A;  1TJ7 A;  3QBP A;  1Z4Q A;  2I7D A;  2D27 A;  2VSF A;  1IW7 D;  2VL7 A;  1TJV A;  1XWO A;  1YIS A;  2PTQ A;  1MH9 A;  2PTS A;  3F4R A;  5F92 A;  1Z4J A;  1DOF A;  1T6J A;  1W27 A;  4FLC A;  2RJR A;  3BHG A;  2O7D A;  2O7E A;  3R6Q A;  1GKM A;  4ADM A;  2O7F A;  3UNV A;  2PTR A;  4A15 A;  1KQ7 A;  1VDK A;  1XLY A;  1GKJ A;  1U15 A;  4BAA A;  1C3C A;  5EYT A;  1YFE A;  5M0J A;  1HY1 A;  2JAW A;  4CQ5 A;  5H8W A;  1FUO A;  4L6C A;  3R6Y A;  4IQJ M;  3NZ4 A;  2E9F A;  3U13 A;  1I0A A;  2OHY A;  4HGV A;  2HVG A;  1Z4I A;  1DCN A;  4MWO A;  1GK3 A;  1T6P A;  1Z4M A;  5F91 A;  4L57 A;  1Z4P X;  3R6V A;  2D28 C;  1XL8 A;  3KDZ A;  3F4T A;  1XMC A;  4NSL A;  4V2Q A;  2YV5 A;  5HW2 A;  5M0I A;  2RCN A;  1Q91 A;  4C5U A;  1U16 A;  1Z4K A;  1K7W A; 
#chains in the Genus database with same CATH homology
 1J3U A;  2FUS A;  1EB4 A;  1Y2M A;  1C3U A;  2PFM A;  3C8T A;  5D6B A;  2RJS A;  1TJW A;  2J91 A;  3GTD A;  2O78 A;  3OCE A;  4APB A;  1FUP A;  4MX2 A;  1FUQ A;  4C5R A;  3E04 A;  2QVE A;  3TV2 A;  1HY0 A;  1JSW A;  4FFX A;  4V2R A;  1Q5N A;  2O7B A;  3KDY A;  4APA A;  3NO9 A;  4NLE A;  1AUW A;  4ADL A;  5EYV A;  2YII A;  1RE5 A;  3OCF A;  3RRP A;  3CZO A;  1K62 A;  1TJU A;  1GK2 A;  4EFC A;  2VD6 A;  4C5S A;  3GZH A;  4EEI A;  1YFM A;  4C6G A;  2X75 A;  2NYN A;  2O6Y A;  1B8F A;  4BAB A;  2NYF A;  2QGA B;  1FUR A;  3RD8 A;  1TJ7 A;  3QBP A;  1TJV A;  1XWO A;  1YIS A;  2PTQ A;  2PTS A;  5F92 A;  1DOF A;  1T6J A;  1W27 A;  4FLC A;  2RJR A;  3BHG A;  2O7D A;  2O7E A;  3R6Q A;  1GKM A;  4ADM A;  2O7F A;  3UNV A;  2PTR A;  1KQ7 A;  1VDK A;  1GKJ A;  1U15 A;  4BAA A;  1C3C A;  5EYT A;  1YFE A;  1HY1 A;  4CQ5 A;  1FUO A;  3R6Y A;  3NZ4 A;  2E9F A;  1I0A A;  2OHY A;  4HGV A;  2HVG A;  1DCN A;  1GK3 A;  1T6P A;  5F91 A;  3KDZ A;  3R6V A;  4NSL A;  4V2Q A;  5HW2 A;  4C5U A;  1U16 A;  1K7W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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