2FUSA

Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site
Total Genus 168
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
168
sequence length
456
structure length
456
Chain Sequence
b'VRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVNPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTHLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQM'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords FUMARASE C
publication title Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolyase
total genus 168
structure length 456
sequence length 456
chains with identical sequence B
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 1997-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 2fusA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2fusA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2fusA02
1FUQA 1TJWA 1YFEA 5HW2A 4ADLA 2HVGA 4APBA 5EYTA 3KDZA 3E04A 2PFMA 5F92A 2FUSA 1C3CA 1K7WA 4HGVA 1GKJA 1FUPA 3CZOA 1FURA 1T6JA 1KQ7A 2NYFA 3BHGA 2PTQA 2NYNA 4C5RA 1W27A 1J3UA 2QVEA 4FFXA 2PTRA 1T6PA 2J91A 5D6BA 2QGAB 4C5SA 1VDKA 1HY0A 3NO9A 2RJSA 2VD6A 1DOFA 2RJRA 4MX2A 1GK3A 2O78A 1U16A 3GZHA 3R6YA 4FLCA 1JSWA 3UNVA 4V2QA 1RE5A 1FUOA 1DCNA 3R6VA 1YFMA 1C3UA 4NSLA 2O7BA 1YISA 1HY1A 1Q5NA 2O6YA 4BABA 1I0AA 1GKMA 3RRPA 3KDYA 1B8FA 5EYVA 1TJUA 4EEIA 4CQ5A 1U15A 3GTDA 4V2RA 4BAAA 4C6GA 4APAA 2O7FA 2X75A 3R6QA 2YIIA 3NZ4A 3OCEA 2PTSA 1K62A 4NLEA 1AUWA 1GK2A 3TV2A 1TJ7A 3RD8A 2E9FA 1Y2MA 2O7EA 4C5UA 5F91A 2O7DA 3QBPA 1XWOA 4ADMA 3OCFA 4EFCA 3C8TA 1EB4A 2OHYA 1TJVA
chains in the Genus database with same CATH superfamily
1FUQA 1TJWA 1YFEA 5HW2A 4A15A 4L6CA 4ADLA 5M0JA 2HVGA 4APBA 5EYTA 3KDZA 4L6AA 3E04A 2PFMA 1XMDA 5F92A 2FUSA 3CI0K 1C3CA 1K7WA 4HGVA 2JAOA 1MH9A 3BWVA 1GKJA 3CRVA 1FUPA 2FENA 1XLYA 2JAWA 3CZOA 1FURA 2VL7A 1T6JA 1KQ7A 1U0LA 2NYFA 3BHGA 2PTQA 2NYNA 4C5RA 1Z4KA 4YIHA 2JAUA 1W27A 2I7DA 3CRW1 1J3UA 2QVEA 2RCNA 4FFXA 2PTRA 1T6PA 2J91A 5D6BA 2QGAB 4C5SA 1VDKA 1HY0A 3NO9A 2RJSA 2VD6A 1Q91A 4E88A 1DOFA 2RJRA 4MX2A 1GK3A 4L57A 1U16A 2O78A 3GZHA 1Z4LA 1XL7A 3R6YA 4FLCA 1JSWA 3UNVA 3U19A 4V2QA 1RE5A 1FUOA 1DCNA 3R6VA 1YFMA 4MUMA 1Q92A 1C3UA 4NSLA 3F4RA 3F4TA 2O7BA 1YISA 1HY1A 1Q5NA 2O6YA 4BABA 1I0AA 2D28C 1GKMA 3RRPA 3KDYA 1B8FA 5EYVA 1TJUA 4EEIA 4CQ5A 2YV5A 5M0IA 1U15A 3GTDA 4IQJM 4V2RA 4BAAA 4C6GA 1Z4MA 4APAA 1XMCA 2O7FA 2X75A 3R6QA 2YIIA 3NZ4A 1Z4PX 2VSFA 3OCEA 2FELA 2PTSA 4WNLA 1K62A 4MWOA 4NLEA 1AUWA 1GK2A 1Z4IA 3TV2A 3F4SA 1TJ7A 1T9HA 3RD8A 2JARA 2D27A 2E9FA 1Y2MA 5H8WA 2O7EA 4C5UA 5F91A 1Z4JA 2O7DA 3QBPA 1XL8A 1XWOA 4ADMA 3OCFA 1IW7D 4YIKA 4EFCA 1Z4QA 3C8TA 1EB4A 2OHYA 3U13A 1TJVA 4NFLA
chains in the Genus database with same CATH topology
1FUQA 1TJWA 1YFEA 5HW2A 4ADLA 2HVGA 4APBA 5EYTA 3KDZA 3E04A 2PFMA 5F92A 2FUSA 1C3CA 1K7WA 4HGVA 1GKJA 1FUPA 3CZOA 1FURA 1T6JA 1KQ7A 2NYFA 3BHGA 2PTQA 2NYNA 4C5RA 1W27A 1J3UA 2QVEA 4FFXA 2PTRA 1T6PA 2J91A 5D6BA 2QGAB 4C5SA 1VDKA 1HY0A 3NO9A 2RJSA 2VD6A 1DOFA 2RJRA 4MX2A 1GK3A 2O78A 1U16A 3GZHA 3R6YA 4FLCA 1JSWA 3UNVA 4V2QA 1RE5A 1FUOA 1DCNA 3R6VA 1YFMA 1C3UA 4NSLA 2O7BA 1YISA 1HY1A 1Q5NA 2O6YA 4BABA 1I0AA 1GKMA 3RRPA 3KDYA 1B8FA 5EYVA 1TJUA 4EEIA 4CQ5A 1U15A 3GTDA 4V2RA 4BAAA 4C6GA 4APAA 2O7FA 2X75A 3R6QA 2YIIA 3NZ4A 3OCEA 2PTSA 1K62A 4NLEA 1AUWA 1GK2A 3TV2A 1TJ7A 3RD8A 2E9FA 1Y2MA 2O7EA 4C5UA 5F91A 2O7DA 3QBPA 1XWOA 4ADMA 3OCFA 4EFCA 3C8TA 1EB4A 2OHYA 1TJVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FUQ A;  1TJW A;  1YFE A;  5HW2 A;  4ADL A;  2HVG A;  4APB A;  5EYT A;  3KDZ A;  3E04 A;  2PFM A;  5F92 A;  2FUS A;  1C3C A;  1K7W A;  4HGV A;  1GKJ A;  1FUP A;  3CZO A;  1FUR A;  1T6J A;  1KQ7 A;  2NYF A;  3BHG A;  2PTQ A;  2NYN A;  4C5R A;  1W27 A;  1J3U A;  2QVE A;  4FFX A;  2PTR A;  1T6P A;  2J91 A;  5D6B A;  2QGA B;  4C5S A;  1VDK A;  1HY0 A;  3NO9 A;  2RJS A;  2VD6 A;  1DOF A;  2RJR A;  4MX2 A;  1GK3 A;  2O78 A;  1U16 A;  3GZH A;  3R6Y A;  4FLC A;  1JSW A;  3UNV A;  4V2Q A;  1RE5 A;  1FUO A;  1DCN A;  3R6V A;  1YFM A;  1C3U A;  4NSL A;  2O7B A;  1YIS A;  1HY1 A;  1Q5N A;  2O6Y A;  4BAB A;  1I0A A;  1GKM A;  3RRP A;  3KDY A;  1B8F A;  5EYV A;  1TJU A;  4EEI A;  4CQ5 A;  1U15 A;  3GTD A;  4V2R A;  4BAA A;  4C6G A;  4APA A;  2O7F A;  2X75 A;  3R6Q A;  2YII A;  3NZ4 A;  3OCE A;  2PTS A;  1K62 A;  4NLE A;  1AUW A;  1GK2 A;  3TV2 A;  1TJ7 A;  3RD8 A;  2E9F A;  1Y2M A;  2O7E A;  4C5U A;  5F91 A;  2O7D A;  3QBP A;  1XWO A;  4ADM A;  3OCF A;  4EFC A;  3C8T A;  1EB4 A;  2OHY A;  1TJV A; 
#chains in the Genus database with same CATH topology
 1FUQ A;  1TJW A;  1YFE A;  5HW2 A;  4A15 A;  4L6C A;  4ADL A;  5M0J A;  2HVG A;  4APB A;  5EYT A;  3KDZ A;  4L6A A;  3E04 A;  2PFM A;  1XMD A;  5F92 A;  2FUS A;  3CI0 K;  1C3C A;  1K7W A;  4HGV A;  2JAO A;  1MH9 A;  3BWV A;  1GKJ A;  3CRV A;  1FUP A;  2FEN A;  1XLY A;  2JAW A;  3CZO A;  1FUR A;  2VL7 A;  1T6J A;  1KQ7 A;  1U0L A;  2NYF A;  3BHG A;  2PTQ A;  2NYN A;  4C5R A;  1Z4K A;  4YIH A;  2JAU A;  1W27 A;  2I7D A;  3CRW 1;  1J3U A;  2QVE A;  2RCN A;  4FFX A;  2PTR A;  1T6P A;  2J91 A;  5D6B A;  2QGA B;  4C5S A;  1VDK A;  1HY0 A;  3NO9 A;  2RJS A;  2VD6 A;  1Q91 A;  4E88 A;  1DOF A;  2RJR A;  4MX2 A;  1GK3 A;  4L57 A;  1U16 A;  2O78 A;  3GZH A;  1Z4L A;  1XL7 A;  3R6Y A;  4FLC A;  1JSW A;  3UNV A;  3U19 A;  4V2Q A;  1RE5 A;  1FUO A;  1DCN A;  3R6V A;  1YFM A;  4MUM A;  1Q92 A;  1C3U A;  4NSL A;  3F4R A;  3F4T A;  2O7B A;  1YIS A;  1HY1 A;  1Q5N A;  2O6Y A;  4BAB A;  1I0A A;  2D28 C;  1GKM A;  3RRP A;  3KDY A;  1B8F A;  5EYV A;  1TJU A;  4EEI A;  4CQ5 A;  2YV5 A;  5M0I A;  1U15 A;  3GTD A;  4IQJ M;  4V2R A;  4BAA A;  4C6G A;  1Z4M A;  4APA A;  1XMC A;  2O7F A;  2X75 A;  3R6Q A;  2YII A;  3NZ4 A;  1Z4P X;  2VSF A;  3OCE A;  2FEL A;  2PTS A;  4WNL A;  1K62 A;  4MWO A;  4NLE A;  1AUW A;  1GK2 A;  1Z4I A;  3TV2 A;  3F4S A;  1TJ7 A;  1T9H A;  3RD8 A;  2JAR A;  2D27 A;  2E9F A;  1Y2M A;  5H8W A;  2O7E A;  4C5U A;  5F91 A;  1Z4J A;  2O7D A;  3QBP A;  1XL8 A;  1XWO A;  4ADM A;  3OCF A;  1IW7 D;  4YIK A;  4EFC A;  1Z4Q A;  3C8T A;  1EB4 A;  2OHY A;  3U13 A;  1TJV A;  4NFL A; 
#chains in the Genus database with same CATH homology
 1FUQ A;  1TJW A;  1YFE A;  5HW2 A;  4ADL A;  2HVG A;  4APB A;  5EYT A;  3KDZ A;  3E04 A;  2PFM A;  5F92 A;  2FUS A;  1C3C A;  1K7W A;  4HGV A;  1GKJ A;  1FUP A;  3CZO A;  1FUR A;  1T6J A;  1KQ7 A;  2NYF A;  3BHG A;  2PTQ A;  2NYN A;  4C5R A;  1W27 A;  1J3U A;  2QVE A;  4FFX A;  2PTR A;  1T6P A;  2J91 A;  5D6B A;  2QGA B;  4C5S A;  1VDK A;  1HY0 A;  3NO9 A;  2RJS A;  2VD6 A;  1DOF A;  2RJR A;  4MX2 A;  1GK3 A;  2O78 A;  1U16 A;  3GZH A;  3R6Y A;  4FLC A;  1JSW A;  3UNV A;  4V2Q A;  1RE5 A;  1FUO A;  1DCN A;  3R6V A;  1YFM A;  1C3U A;  4NSL A;  2O7B A;  1YIS A;  1HY1 A;  1Q5N A;  2O6Y A;  4BAB A;  1I0A A;  1GKM A;  3RRP A;  3KDY A;  1B8F A;  5EYV A;  1TJU A;  4EEI A;  4CQ5 A;  1U15 A;  3GTD A;  4V2R A;  4BAA A;  4C6G A;  4APA A;  2O7F A;  2X75 A;  3R6Q A;  2YII A;  3NZ4 A;  3OCE A;  2PTS A;  1K62 A;  4NLE A;  1AUW A;  1GK2 A;  3TV2 A;  1TJ7 A;  3RD8 A;  2E9F A;  1Y2M A;  2O7E A;  4C5U A;  5F91 A;  2O7D A;  3QBP A;  1XWO A;  4ADM A;  3OCF A;  4EFC A;  3C8T A;  1EB4 A;  2OHY A;  1TJV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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