2FY3A

Structures of ligand bound human choline acetyltransferase provides insight into regulation of acetylcholine synthesis
Total Genus 235
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
235
sequence length
599
structure length
595
Chain Sequence
SEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDCAKGQPLCMKQYYGLFSSYRLPGHTQDTLVAQNSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNAAARLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQPELVRSPMVPLPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCAALPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCAATSSSKFAKAVEESLIDMRDLCSLLPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Choline O-acetyltransferase
publication title Substrate binding and catalytic mechanism of human choline acetyltransferase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 235
structure length 595
sequence length 599
ec nomenclature ec 2.3.1.6: Choline O-acetyltransferase.
pdb deposition date 2006-02-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00755 Carn_acyltransf Choline/Carnitine o-acyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.40 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy3A01
3.30.559.70 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy3A02
1T7OA 2H4TA 1NDIA 2H3PA 2FY2A 2H3WA 1NM8A 2H3UA 4EPHA 1T7QA 1T1UA 2FW3A 4EP9A 1T7NA 1Q6XA 2FY5A 2RCUA 2DEBA 1NDBA 1NDFA 4EYWA 2FY3A 2FY4A 2FYOA 1S5OA
chains in the Genus database with same CATH superfamily
5KJWA 1T7OA 5KJVA 1DPCA 2CLAA 1EAFA 2RKTA 1NDIA 5T3EA 1T1UA 2XR7A 4EP9A 2FY5A 2I9DA 2ZBAA 3CLAA 1EABA 5KJUA 4EYWA 2FY3A 2FY4A 1Q9JA 4JN5A 5DUAA 2H4TA 2H3PA 2RKVA 1EAEA 1NM8A 5DU9A 1XL8A 5KJSA 2VSQA 2FW3A 3L60A 2BGHA 4CLAA 1Q6XA 2XHGA 2RCUA 2DEBA 2E1VA 4JN3A 1PD5A 1XMCA 4G2MA 5FANA 1C4TA 4KE4A 2FY2A 2H3WA 2JGPA 2H3UA 1NOCB 4KECA 1T7QA 1L5AA 2II4A 4N72A 3MAEA 1Q23A 1NDFA 1NDBA 1CLAA 2FYOA 1S5OA 1EACA 2II3A 3U9BA 3FOTA 1CIAA 1E2OA 1DPDA 3B30A 1SCZA 4HVMA 3B2SA 4G0BA 4G22A 1DPBA 4EPHA 3U9FA 2E1TA 2E1UA 5KJTA 1XMDA 2II5A 1T7NA 5FALA 1QCAA 1EADA 1EAAA 1XL7A 3FP0A 2IHWA
chains in the Genus database with same CATH topology
5DUAA 1T7OA 4HVMA 2H4TA 5T3EA 1NDIA 2H3PA 2FY2A 2H3WA 2JGPA 1NM8A 2H3UA 5DU9A 4EPHA 2VSQA 1T7QA 1T1UA 1L5AA 2FW3A 4EP9A 1T7NA 1Q6XA 2FY5A 2XHGA 2RCUA 2DEBA 1NDBA 1NDFA 4JN3A 4EYWA 2FY3A 2FY4A 1Q9JA 2FYOA 1S5OA 3FP0A 4JN5A 3FOTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T7O A;  2H4T A;  1NDI A;  2H3P A;  2FY2 A;  2H3W A;  1NM8 A;  2H3U A;  4EPH A;  1T7Q A;  1T1U A;  2FW3 A;  4EP9 A;  1T7N A;  1Q6X A;  2FY5 A;  2RCU A;  2DEB A;  1NDB A;  1NDF A;  4EYW A;  2FY3 A;  2FY4 A;  2FYO A;  1S5O A; 
#chains in the Genus database with same CATH topology
 5KJW A;  1T7O A;  5KJV A;  1DPC A;  2CLA A;  1EAF A;  2RKT A;  1NDI A;  5T3E A;  1T1U A;  2XR7 A;  4EP9 A;  2FY5 A;  2I9D A;  2ZBA A;  3CLA A;  1EAB A;  5KJU A;  4EYW A;  2FY3 A;  2FY4 A;  1Q9J A;  4JN5 A;  5DUA A;  2H4T A;  2H3P A;  2RKV A;  1EAE A;  1NM8 A;  5DU9 A;  1XL8 A;  5KJS A;  2VSQ A;  2FW3 A;  3L60 A;  2BGH A;  4CLA A;  1Q6X A;  2XHG A;  2RCU A;  2DEB A;  2E1V A;  4JN3 A;  1PD5 A;  1XMC A;  4G2M A;  5FAN A;  1C4T A;  4KE4 A;  2FY2 A;  2H3W A;  2JGP A;  2H3U A;  1NOC B;  4KEC A;  1T7Q A;  1L5A A;  2II4 A;  4N72 A;  3MAE A;  1Q23 A;  1NDF A;  1NDB A;  1CLA A;  2FYO A;  1S5O A;  1EAC A;  2II3 A;  3U9B A;  3FOT A;  1CIA A;  1E2O A;  1DPD A;  3B30 A;  1SCZ A;  4HVM A;  3B2S A;  4G0B A;  4G22 A;  1DPB A;  4EPH A;  3U9F A;  2E1T A;  2E1U A;  5KJT A;  1XMD A;  2II5 A;  1T7N A;  5FAL A;  1QCA A;  1EAD A;  1EAA A;  1XL7 A;  3FP0 A;  2IHW A; 
#chains in the Genus database with same CATH homology
 5DUA A;  1T7O A;  4HVM A;  2H4T A;  5T3E A;  1NDI A;  2H3P A;  2FY2 A;  2H3W A;  2JGP A;  1NM8 A;  2H3U A;  5DU9 A;  4EPH A;  2VSQ A;  1T7Q A;  1T1U A;  1L5A A;  2FW3 A;  4EP9 A;  1T7N A;  1Q6X A;  2FY5 A;  2XHG A;  2RCU A;  2DEB A;  1NDB A;  1NDF A;  4JN3 A;  4EYW A;  2FY3 A;  2FY4 A;  1Q9J A;  2FYO A;  1S5O A;  3FP0 A;  4JN5 A;  3FOT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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