2FY3A

Structures of ligand bound human choline acetyltransferase provides insight into regulation of acetylcholine synthesis
Total Genus 235
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
235
sequence length
599
structure length
595
Chain Sequence
SEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDCAKGQPLCMKQYYGLFSSYRLPGHTQDTLVAQNSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNAAARLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQPELVRSPMVPLPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCAALPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCAATSSSKFAKAVEESLIDMRDLCSLLPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Choline O-acetyltransferase
publication title Substrate binding and catalytic mechanism of human choline acetyltransferase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 235
structure length 595
sequence length 599
ec nomenclature ec 2.3.1.6: Choline O-acetyltransferase.
pdb deposition date 2006-02-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00755 Carn_acyltransf Choline/Carnitine o-acyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.40 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy3A01
3.30.559.70 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy3A02
1NDFA 2FW3A 2FY2A 2RCUA 1T1UA 1T7OA 2H4TA 4EPHA 4EYWA 2FY5A 2FY4A 2FYOA 1NM8A 2FY3A 1T7QA 2H3UA 2DEBA 1Q6XA 1NDBA 4EP9A 1T7NA 2H3PA 1S5OA 1NDIA 2H3WA
chains in the Genus database with same CATH superfamily
5KJTA 1NDFA 3FOTA 5T3EA 3B2SA 1T1UA 1Q9JA 4EPHA 4KECA 2BGHA 1QCAA 2FY4A 3FP0A 2E1TA 5KJSA 5KJVA 2H3UA 1XMDA 2DEBA 3U9FA 1EADA 1Q6XA 1NDBA 1C4TA 1T7NA 2H3PA 1L5AA 4G22A 1NOCB 2FY2A 2RCUA 2II3A 1CIAA 1DPCA 2H4TA 1EACA 5FANA 5DU9A 2FYOA 1NM8A 2CLAA 2E1UA 1EABA 4EP9A 4N72A 1XL8A 1S5OA 2IHWA 1Q23A 2II4A 2XR7A 4G0BA 4HVMA 5KJWA 1DPDA 4EYWA 2VSQA 2FY5A 4JN5A 1E2OA 5KJUA 1T7QA 3U9BA 4JN3A 2XHGA 1EAEA 1EAFA 1SCZA 3B30A 2RKVA 4KE4A 1NDIA 2H3WA 2RKTA 2ZBAA 1CLAA 2FW3A 2JGPA 2E1VA 1T7OA 3CLAA 1XMCA 4G2MA 2II5A 3L60A 3MAEA 2FY3A 1DPBA 4CLAA 1XL7A 5FALA 1PD5A 1EAAA 2I9DA 5DUAA
chains in the Genus database with same CATH topology
1NDFA 2FW3A 3FOTA 5T3EA 2FY2A 2RCUA 1T1UA 2JGPA 1T7OA 2H4TA 4HVMA 1Q9JA 4EPHA 4EYWA 2VSQA 2FY5A 2FY4A 3FP0A 5DU9A 2FYOA 4JN5A 1NM8A 2FY3A 1T7QA 4JN3A 2XHGA 2H3UA 2DEBA 1Q6XA 1NDBA 4EP9A 1T7NA 2H3PA 5DUAA 1S5OA 1L5AA 1NDIA 2H3WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NDF A;  2FW3 A;  2FY2 A;  2RCU A;  1T1U A;  1T7O A;  2H4T A;  4EPH A;  4EYW A;  2FY5 A;  2FY4 A;  2FYO A;  1NM8 A;  2FY3 A;  1T7Q A;  2H3U A;  2DEB A;  1Q6X A;  1NDB A;  4EP9 A;  1T7N A;  2H3P A;  1S5O A;  1NDI A;  2H3W A; 
#chains in the Genus database with same CATH topology
 5KJT A;  1NDF A;  3FOT A;  5T3E A;  3B2S A;  1T1U A;  1Q9J A;  4EPH A;  4KEC A;  2BGH A;  1QCA A;  2FY4 A;  3FP0 A;  2E1T A;  5KJS A;  5KJV A;  2H3U A;  1XMD A;  2DEB A;  3U9F A;  1EAD A;  1Q6X A;  1NDB A;  1C4T A;  1T7N A;  2H3P A;  1L5A A;  4G22 A;  1NOC B;  2FY2 A;  2RCU A;  2II3 A;  1CIA A;  1DPC A;  2H4T A;  1EAC A;  5FAN A;  5DU9 A;  2FYO A;  1NM8 A;  2CLA A;  2E1U A;  1EAB A;  4EP9 A;  4N72 A;  1XL8 A;  1S5O A;  2IHW A;  1Q23 A;  2II4 A;  2XR7 A;  4G0B A;  4HVM A;  5KJW A;  1DPD A;  4EYW A;  2VSQ A;  2FY5 A;  4JN5 A;  1E2O A;  5KJU A;  1T7Q A;  3U9B A;  4JN3 A;  2XHG A;  1EAE A;  1EAF A;  1SCZ A;  3B30 A;  2RKV A;  4KE4 A;  1NDI A;  2H3W A;  2RKT A;  2ZBA A;  1CLA A;  2FW3 A;  2JGP A;  2E1V A;  1T7O A;  3CLA A;  1XMC A;  4G2M A;  2II5 A;  3L60 A;  3MAE A;  2FY3 A;  1DPB A;  4CLA A;  1XL7 A;  5FAL A;  1PD5 A;  1EAA A;  2I9D A;  5DUA A; 
#chains in the Genus database with same CATH homology
 1NDF A;  2FW3 A;  3FOT A;  5T3E A;  2FY2 A;  2RCU A;  1T1U A;  2JGP A;  1T7O A;  2H4T A;  4HVM A;  1Q9J A;  4EPH A;  4EYW A;  2VSQ A;  2FY5 A;  2FY4 A;  3FP0 A;  5DU9 A;  2FYO A;  4JN5 A;  1NM8 A;  2FY3 A;  1T7Q A;  4JN3 A;  2XHG A;  2H3U A;  2DEB A;  1Q6X A;  1NDB A;  4EP9 A;  1T7N A;  2H3P A;  5DUA A;  1S5O A;  1L5A A;  1NDI A;  2H3W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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