2FY3A

Structures of ligand bound human choline acetyltransferase provides insight into regulation of acetylcholine synthesis
Total Genus 235
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
235
sequence length
599
structure length
595
Chain Sequence
b'SEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDCAKGQPLCMKQYYGLFSSYRLPGHTQDTLVAQNSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNAAARLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQPELVRSPMVPLPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCAALPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCAATSSSKFAKAVEESLIDMRDLCSLLPP'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Choline O-acetyltransferase
publication title Substrate binding and catalytic mechanism of human choline acetyltransferase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 235
structure length 595
sequence length 599
ec nomenclature ec 2.3.1.6: Choline O-acetyltransferase.
pdb deposition date 2006-02-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00755 Carn_acyltransf Choline/Carnitine o-acyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.40 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy3A01
3.30.559.70 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy3A02
2RCUA 1Q6XA 1NDFA 2FW3A 1T7QA 2FY5A 1T1UA 1NM8A 1T7OA 2FY4A 1NDIA 2H3WA 2FY3A 2H3PA 2FYOA 2H4TA 4EP9A 1T7NA 2DEBA 2FY2A 2H3UA 4EYWA 1NDBA 1S5OA 4EPHA
chains in the Genus database with same CATH superfamily
3B30A 1DPDA 1PD5A 5KJTA 1NDFA 4N72A 2IHWA 1DPBA 4JN3A 1Q9JA 1CIAA 3L60A 1T1UA 1CLAA 5DU9A 5KJWA 1EACA 1NM8A 2H3WA 2FY3A 2H3PA 4KE4A 1XMDA 5FANA 1E2OA 2H4TA 2XR7A 4EP9A 2H3UA 4EYWA 1Q23A 1EABA 5T3EA 4HVMA 3CLAA 3FP0A 2RKVA 2RKTA 2RCUA 1XMCA 1NOCB 2FW3A 4G0BA 1T7QA 2FY5A 2E1UA 2XHGA 1EAFA 1NDIA 2FYOA 2ZBAA 2DEBA 3FOTA 2JGPA 2BGHA 4G22A 3U9FA 1EAEA 5DUAA 4KECA 1C4TA 1EADA 1QCAA 4G2MA 5FALA 3MAEA 2E1TA 3U9BA 1T7NA 2II4A 2FY2A 2VSQA 1NDBA 1XL7A 5KJVA 2II3A 2E1VA 1S5OA 1SCZA 1EAAA 1Q6XA 2II5A 5KJUA 2I9DA 1XL8A 1T7OA 2FY4A 5KJSA 1L5AA 2CLAA 3B2SA 4JN5A 1DPCA 4CLAA 4EPHA
chains in the Genus database with same CATH topology
2RCUA 1Q6XA 1NDFA 5DUAA 2FW3A 1T7QA 2FY5A 4JN3A 1Q9JA 5DU9A 1T1UA 2XHGA 1NM8A 1T7OA 2FY4A 1NDIA 2H3WA 2FY3A 2H3PA 2FYOA 2H4TA 4EP9A 1T7NA 2DEBA 2FY2A 2VSQA 2H3UA 3FOTA 1NDBA 4EYWA 2JGPA 1L5AA 5T3EA 4JN5A 4HVMA 1S5OA 3FP0A 4EPHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RCU A;  1Q6X A;  1NDF A;  2FW3 A;  1T7Q A;  2FY5 A;  1T1U A;  1NM8 A;  1T7O A;  2FY4 A;  1NDI A;  2H3W A;  2FY3 A;  2H3P A;  2FYO A;  2H4T A;  4EP9 A;  1T7N A;  2DEB A;  2FY2 A;  2H3U A;  4EYW A;  1NDB A;  1S5O A;  4EPH A; 
#chains in the Genus database with same CATH topology
 3B30 A;  1DPD A;  1PD5 A;  5KJT A;  1NDF A;  4N72 A;  2IHW A;  1DPB A;  4JN3 A;  1Q9J A;  1CIA A;  3L60 A;  1T1U A;  1CLA A;  5DU9 A;  5KJW A;  1EAC A;  1NM8 A;  2H3W A;  2FY3 A;  2H3P A;  4KE4 A;  1XMD A;  5FAN A;  1E2O A;  2H4T A;  2XR7 A;  4EP9 A;  2H3U A;  4EYW A;  1Q23 A;  1EAB A;  5T3E A;  4HVM A;  3CLA A;  3FP0 A;  2RKV A;  2RKT A;  2RCU A;  1XMC A;  1NOC B;  2FW3 A;  4G0B A;  1T7Q A;  2FY5 A;  2E1U A;  2XHG A;  1EAF A;  1NDI A;  2FYO A;  2ZBA A;  2DEB A;  3FOT A;  2JGP A;  2BGH A;  4G22 A;  3U9F A;  1EAE A;  5DUA A;  4KEC A;  1C4T A;  1EAD A;  1QCA A;  4G2M A;  5FAL A;  3MAE A;  2E1T A;  3U9B A;  1T7N A;  2II4 A;  2FY2 A;  2VSQ A;  1NDB A;  1XL7 A;  5KJV A;  2II3 A;  2E1V A;  1S5O A;  1SCZ A;  1EAA A;  1Q6X A;  2II5 A;  5KJU A;  2I9D A;  1XL8 A;  1T7O A;  2FY4 A;  5KJS A;  1L5A A;  2CLA A;  3B2S A;  4JN5 A;  1DPC A;  4CLA A;  4EPH A; 
#chains in the Genus database with same CATH homology
 2RCU A;  1Q6X A;  1NDF A;  5DUA A;  2FW3 A;  1T7Q A;  2FY5 A;  4JN3 A;  1Q9J A;  5DU9 A;  1T1U A;  2XHG A;  1NM8 A;  1T7O A;  2FY4 A;  1NDI A;  2H3W A;  2FY3 A;  2H3P A;  2FYO A;  2H4T A;  4EP9 A;  1T7N A;  2DEB A;  2FY2 A;  2VSQ A;  2H3U A;  3FOT A;  1NDB A;  4EYW A;  2JGP A;  1L5A A;  5T3E A;  4JN5 A;  4HVM A;  1S5O A;  3FP0 A;  4EPH A; 
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similar chains in the pdb database (?% sequence similarity)

 
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