2FY4A

Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis
Total Genus 232
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
232
sequence length
593
structure length
589
Chain Sequence
b'SGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTLVAQMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNAAARLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQPELVRSPMVPLPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCAALPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCAATSSSKFAKAVEESLIDMRDLCSL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Choline O-acetyltransferase
publication title Substrate binding and catalytic mechanism of human choline acetyltransferase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 232
structure length 589
sequence length 593
ec nomenclature ec 2.3.1.6: Choline O-acetyltransferase.
pdb deposition date 2006-02-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00755 Carn_acyltransf Choline/Carnitine o-acyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.40 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy4A01
3.30.559.70 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy4A02
2FW3A 1NDIA 2H4TA 2FY4A 2DEBA 2FY3A 2FY2A 1S5OA 2H3PA 4EP9A 1Q6XA 1T7OA 1NDFA 2H3UA 1T1UA 2FY5A 2RCUA 1T7NA 4EYWA 2FYOA 1NDBA 1T7QA 1NM8A 2H3WA 4EPHA
chains in the Genus database with same CATH superfamily
1DPBA 1EAEA 2H4TA 4G0BA 5DU9A 1NOCB 2FY3A 2IHWA 1CLAA 1EAFA 2FY5A 3CLAA 1EACA 5DUAA 1XL8A 2FYOA 1SCZA 3FOTA 2II5A 1NM8A 2H3WA 2JGPA 1E2OA 2RKTA 5FANA 5KJVA 3B2SA 1S5OA 4G2MA 1CIAA 1T7OA 4KECA 1T1UA 1EADA 5T3EA 3L60A 5KJSA 4EYWA 1T7QA 2E1TA 4G22A 4KE4A 3MAEA 1XL7A 2E1UA 2CLAA 1EAAA 2FW3A 5KJWA 3B30A 2FY2A 2H3PA 1DPDA 4EP9A 5FALA 2RKVA 3FP0A 2I9DA 1NDFA 2H3UA 4JN3A 1QCAA 1T7NA 2BGHA 2XR7A 5KJUA 4CLAA 1L5AA 1NDBA 2VSQA 1XMCA 1DPCA 1Q9JA 4EPHA 4HVMA 2II3A 1NDIA 1C4TA 3U9BA 2FY4A 2DEBA 1EABA 4N72A 5KJTA 2XHGA 1Q6XA 2RCUA 3U9FA 2II4A 1Q23A 1XMDA 4JN5A 2ZBAA 1PD5A 2E1VA
chains in the Genus database with same CATH topology
2FW3A 1NDIA 2H4TA 5DU9A 2FY4A 2DEBA 2FY3A 2FY2A 1S5OA 4HVMA 2H3PA 2XHGA 4EP9A 1Q6XA 1T7OA 3FP0A 1NDFA 2H3UA 1T1UA 2FY5A 4JN3A 2RCUA 1T7NA 5DUAA 5T3EA 1L5AA 4EYWA 2FYOA 1NDBA 1T7QA 2VSQA 3FOTA 1NM8A 4JN5A 2H3WA 1Q9JA 2JGPA 4EPHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FW3 A;  1NDI A;  2H4T A;  2FY4 A;  2DEB A;  2FY3 A;  2FY2 A;  1S5O A;  2H3P A;  4EP9 A;  1Q6X A;  1T7O A;  1NDF A;  2H3U A;  1T1U A;  2FY5 A;  2RCU A;  1T7N A;  4EYW A;  2FYO A;  1NDB A;  1T7Q A;  1NM8 A;  2H3W A;  4EPH A; 
#chains in the Genus database with same CATH topology
 1DPB A;  1EAE A;  2H4T A;  4G0B A;  5DU9 A;  1NOC B;  2FY3 A;  2IHW A;  1CLA A;  1EAF A;  2FY5 A;  3CLA A;  1EAC A;  5DUA A;  1XL8 A;  2FYO A;  1SCZ A;  3FOT A;  2II5 A;  1NM8 A;  2H3W A;  2JGP A;  1E2O A;  2RKT A;  5FAN A;  5KJV A;  3B2S A;  1S5O A;  4G2M A;  1CIA A;  1T7O A;  4KEC A;  1T1U A;  1EAD A;  5T3E A;  3L60 A;  5KJS A;  4EYW A;  1T7Q A;  2E1T A;  4G22 A;  4KE4 A;  3MAE A;  1XL7 A;  2E1U A;  2CLA A;  1EAA A;  2FW3 A;  5KJW A;  3B30 A;  2FY2 A;  2H3P A;  1DPD A;  4EP9 A;  5FAL A;  2RKV A;  3FP0 A;  2I9D A;  1NDF A;  2H3U A;  4JN3 A;  1QCA A;  1T7N A;  2BGH A;  2XR7 A;  5KJU A;  4CLA A;  1L5A A;  1NDB A;  2VSQ A;  1XMC A;  1DPC A;  1Q9J A;  4EPH A;  4HVM A;  2II3 A;  1NDI A;  1C4T A;  3U9B A;  2FY4 A;  2DEB A;  1EAB A;  4N72 A;  5KJT A;  2XHG A;  1Q6X A;  2RCU A;  3U9F A;  2II4 A;  1Q23 A;  1XMD A;  4JN5 A;  2ZBA A;  1PD5 A;  2E1V A; 
#chains in the Genus database with same CATH homology
 2FW3 A;  1NDI A;  2H4T A;  5DU9 A;  2FY4 A;  2DEB A;  2FY3 A;  2FY2 A;  1S5O A;  4HVM A;  2H3P A;  2XHG A;  4EP9 A;  1Q6X A;  1T7O A;  3FP0 A;  1NDF A;  2H3U A;  1T1U A;  2FY5 A;  4JN3 A;  2RCU A;  1T7N A;  5DUA A;  5T3E A;  1L5A A;  4EYW A;  2FYO A;  1NDB A;  1T7Q A;  2VSQ A;  3FOT A;  1NM8 A;  4JN5 A;  2H3W A;  1Q9J A;  2JGP A;  4EPH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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