2FY4A

Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis
Total Genus 232
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
232
sequence length
593
structure length
589
Chain Sequence
SGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTLVAQMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNAAARLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQPELVRSPMVPLPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCAALPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCAATSSSKFAKAVEESLIDMRDLCSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Choline O-acetyltransferase
publication title Substrate binding and catalytic mechanism of human choline acetyltransferase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 232
structure length 589
sequence length 593
ec nomenclature ec 2.3.1.6: Choline O-acetyltransferase.
pdb deposition date 2006-02-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00755 Carn_acyltransf Choline/Carnitine o-acyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.40 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy4A01
3.30.559.70 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy4A02
4EYWA 2DEBA 2H4TA 1NDBA 1NM8A 1NDIA 2FY4A 1T7NA 2FY3A 1T7OA 2H3UA 2H3PA 2RCUA 1S5OA 2FYOA 2FW3A 1Q6XA 2H3WA 2FY5A 4EPHA 4EP9A 2FY2A 1NDFA 1T7QA 1T1UA
chains in the Genus database with same CATH superfamily
2II3A 3U9FA 1XMDA 1NDBA 2CLAA 1T7NA 1EADA 2FY3A 4G22A 1Q9JA 1XMCA 3L60A 1SCZA 2H3WA 2JGPA 3B2SA 3MAEA 5FALA 2VSQA 1T7QA 1T1UA 3B30A 2XHGA 2H4TA 1PD5A 5DUAA 1XL8A 2RKTA 5KJVA 2E1UA 2H3UA 2RCUA 4CLAA 1S5OA 2FW3A 4JN5A 1L5AA 5KJWA 4G0BA 2II4A 4EYWA 2IHWA 1Q23A 4JN3A 3FP0A 2DEBA 4HVMA 1CIAA 1NM8A 2FY4A 1EAAA 4KECA 1DPBA 1T7OA 2H3PA 1E2OA 2E1TA 2ZBAA 1EAEA 2BGHA 4EPHA 1EAFA 3CLAA 2FY2A 3U9BA 1QCAA 1CLAA 1XL7A 1DPCA 5KJUA 5KJTA 1EABA 1NDIA 2RKVA 2I9DA 3FOTA 5DU9A 4KE4A 5FANA 2XR7A 2II5A 4N72A 4G2MA 2E1VA 2FYOA 5KJSA 1Q6XA 1DPDA 1NOCB 2FY5A 4EP9A 1EACA 1C4TA 1NDFA 5T3EA
chains in the Genus database with same CATH topology
4EYWA 4JN3A 3FP0A 2DEBA 4HVMA 2XHGA 2H4TA 5DUAA 1NDBA 1NM8A 1NDIA 2FY4A 3FOTA 1T7NA 5DU9A 2FY3A 1T7OA 2H3UA 2H3PA 2RCUA 1Q9JA 1S5OA 2FYOA 2FW3A 1Q6XA 2H3WA 2JGPA 4JN5A 2FY5A 1L5AA 4EPHA 4EP9A 2FY2A 2VSQA 1NDFA 1T7QA 1T1UA 5T3EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EYW A;  2DEB A;  2H4T A;  1NDB A;  1NM8 A;  1NDI A;  2FY4 A;  1T7N A;  2FY3 A;  1T7O A;  2H3U A;  2H3P A;  2RCU A;  1S5O A;  2FYO A;  2FW3 A;  1Q6X A;  2H3W A;  2FY5 A;  4EPH A;  4EP9 A;  2FY2 A;  1NDF A;  1T7Q A;  1T1U A; 
#chains in the Genus database with same CATH topology
 2II3 A;  3U9F A;  1XMD A;  1NDB A;  2CLA A;  1T7N A;  1EAD A;  2FY3 A;  4G22 A;  1Q9J A;  1XMC A;  3L60 A;  1SCZ A;  2H3W A;  2JGP A;  3B2S A;  3MAE A;  5FAL A;  2VSQ A;  1T7Q A;  1T1U A;  3B30 A;  2XHG A;  2H4T A;  1PD5 A;  5DUA A;  1XL8 A;  2RKT A;  5KJV A;  2E1U A;  2H3U A;  2RCU A;  4CLA A;  1S5O A;  2FW3 A;  4JN5 A;  1L5A A;  5KJW A;  4G0B A;  2II4 A;  4EYW A;  2IHW A;  1Q23 A;  4JN3 A;  3FP0 A;  2DEB A;  4HVM A;  1CIA A;  1NM8 A;  2FY4 A;  1EAA A;  4KEC A;  1DPB A;  1T7O A;  2H3P A;  1E2O A;  2E1T A;  2ZBA A;  1EAE A;  2BGH A;  4EPH A;  1EAF A;  3CLA A;  2FY2 A;  3U9B A;  1QCA A;  1CLA A;  1XL7 A;  1DPC A;  5KJU A;  5KJT A;  1EAB A;  1NDI A;  2RKV A;  2I9D A;  3FOT A;  5DU9 A;  4KE4 A;  5FAN A;  2XR7 A;  2II5 A;  4N72 A;  4G2M A;  2E1V A;  2FYO A;  5KJS A;  1Q6X A;  1DPD A;  1NOC B;  2FY5 A;  4EP9 A;  1EAC A;  1C4T A;  1NDF A;  5T3E A; 
#chains in the Genus database with same CATH homology
 4EYW A;  4JN3 A;  3FP0 A;  2DEB A;  4HVM A;  2XHG A;  2H4T A;  5DUA A;  1NDB A;  1NM8 A;  1NDI A;  2FY4 A;  3FOT A;  1T7N A;  5DU9 A;  2FY3 A;  1T7O A;  2H3U A;  2H3P A;  2RCU A;  1Q9J A;  1S5O A;  2FYO A;  2FW3 A;  1Q6X A;  2H3W A;  2JGP A;  4JN5 A;  2FY5 A;  1L5A A;  4EPH A;  4EP9 A;  2FY2 A;  2VSQ A;  1NDF A;  1T7Q A;  1T1U A;  5T3E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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