2G7IA

Structure of human complement factor h carboxyl terminal domains 19-20: a basis for atypical hemolytic uremic syndrome
Total Genus 22
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
124
structure length
124
Chain Sequence
GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Complement factor H
total genus 22
structure length 124
sequence length 124
ec nomenclature
pdb deposition date 2006-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2g7iA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2g7iA02
3OEDC 2IZ3A 2EC3A 1ZJKA 2CG6A 1QGBA 2KMSA 5HYPA 4AYMA 1Z92B 4ZH1D 1TPGA 1NWVA 1GHQB 1E8BA 3M7PA 2XRDA 3RJ3D 1C1ZA 1GKNA 1LY2A 1HFHA 5JPMG 4WJG2 2IZ4A 2ERJA 4FXGG 4K12A 4C16A 3KXVA 2O39C 3T5OA 3TVJA 1GKGA 1U5MA 3OXUD 1O9AA 5HZPB 2MCZA 1G4FA 3EJHA 1PPQA 2YRAA 2JGWA 2W80A 4LOTA 1OK1A 1E88A 1HFIA 5I0QB 1UOTP 1VVCA 3MQLA 2JRAA 3INBC 3KZJA 5HYTB 1VVDA 2A55A 3L89M 2XRBA 1ELVA 2CKUA 3O8EB 3IU3I 2JGXA 2XWJI 4AYDA 1OK3A 2G7IA 4A5WB 1Q3XA 2YBYA 2BZMA 1TPMA 1QO6A 3NFPI 1H2QP 5FO8C 3GOVA 4ONTD 4PZ5A 5HYUB 4B2RA 3R62A 3ZD1A 1SRZA 2RLPA 2V8EA 1H03P 1SS2A 2XQWC 1OJWA 2EHFA 2QY0A 4J38B 1OJYA 3ERBA 1FBRA 2B5ID 2UWNA 1HCCA 1G4GA 3IX0A 4YNXA 4AYIA 2RKYA 1QUBA 2RLQA 2W81A 1H2PP 1MD7A 1OJVA 1OK9A 1MD8A 4DJZA 3SW0X 4MUCA 3ZD2A 2XWBF 1E5GA 4AYEA 1GPZA 4F4OC 1CKLA 4CSYA 2RL0A 2LOJA 2RKZA 2KRIA 4KKDA 3GXEA 4LOSA 4B2SA 2WIIC 1OK2A 3CALA 3ZRZA 3OP8A 2CG7A 1TPNA 4IGDA 4JHSA 1H04P 2MCYA
chains in the Genus database with same CATH superfamily
4N7EA 3OEDC 2IZ3A 2EC3A 1ZJKA 2CG6A 1QGBA 2KMSA 5HYPA 4AYMA 1Z92B 4ZH1D 1TPGA 1NWVA 1GHQB 1E8BA 3M7PA 2XRDA 3RJ3D 1C1ZA 1GKNA 1LY2A 1HFHA 3WSXA 5JPMG 4WJG2 2IZ4A 2ERJA 4FXGG 4K12A 4C16A 3KXVA 2I2LA 2O39C 3T5OA 3TVJA 1GKGA 1U5MA 3OXUD 1O9AA 5HZPB 2MCZA 1G4FA 3EJHA 1PPQA 2YRAA 2JGWA 2W80A 2ZYCA 4LOTA 1OK1A 1E88A 1HFIA 2Y8SA 1UOTP 3ZLDA 5I0QB 1VVCA 3MQLA 2JRAA 3INBC 3KZJA 5HYTB 1VVDA 2A55A 3L89M 2XRBA 3VWOA 1ELVA 2CKUA 3O8EB 3IU3I 2JGXA 2XWJI 4AYDA 1OK3A 2G7IA 4A5WB 1Q3XA 2YBYA 2BZMA 1TPMA 1QO6A 3NFPI 4PO7A 1H2QP 5FO8C 3GOVA 4ONTD 4PZ5A 2Y8TA 5HYUB 2X2ZA 1RLHA 4B2RA 3R62A 3ZD1A 1SRZA 2RLPA 2V8EA 1H03P 1SS2A 2XQWC 3NJAA 1OJWA 2EHFA 2QY0A 4J38B 1OJYA 3ERBA 1FBRA 2B5ID 3F6KA 3FGTA 2UWNA 3CI0J 3FGRA 1HCCA 4BWCA 5DN5A 1G4GA 3IX0A 4YNXA 4AYIA 2RKYA 1QUBA 2RLQA 2W81A 1H2PP 1MD7A 1OJVA 3WSYA 1OK9A 1MD8A 4DJZA 3SW0X 4MUCA 3ZD2A 2XWBF 2Y8RA 1E5GA 4AYEA 1GPZA 4F4OC 1CKLA 4CSYA 2RL0A 2LOJA 2RKZA 2KRIA 4KKDA 3GXEA 4LOSA 4B2SA 4MSLA 2WIIC 3ZLEA 1OK2A 3CALA 3ZRZA 3OP8A 2CG7A 3K3TA 1TPNA 4APLA 4YIZA 4IGDA 5DN4A 4JHSA 1H04P 2MCYA
chains in the Genus database with same CATH topology
3OEDC 2IZ3A 2EC3A 1ZJKA 2CG6A 1QGBA 2KMSA 5HYPA 4AYMA 1Z92B 4ZH1D 1TPGA 1NWVA 1GHQB 1E8BA 3M7PA 2XRDA 3RJ3D 1C1ZA 1GKNA 1LY2A 1HFHA 5JPMG 4WJG2 2IZ4A 2ERJA 4FXGG 4K12A 4C16A 3KXVA 2O39C 3T5OA 3TVJA 1GKGA 1U5MA 3OXUD 1O9AA 5HZPB 2MCZA 1G4FA 3EJHA 1PPQA 2YRAA 2JGWA 2W80A 4LOTA 1OK1A 1E88A 1HFIA 5I0QB 1UOTP 1VVCA 3MQLA 2JRAA 3INBC 3KZJA 5HYTB 1VVDA 2A55A 3L89M 2XRBA 1ELVA 2CKUA 3O8EB 3IU3I 2JGXA 2XWJI 4AYDA 1OK3A 2G7IA 4A5WB 1Q3XA 2YBYA 2BZMA 1TPMA 1QO6A 3NFPI 1H2QP 5FO8C 3GOVA 4ONTD 4PZ5A 5HYUB 4B2RA 3R62A 3ZD1A 1SRZA 2RLPA 2V8EA 1H03P 1SS2A 2XQWC 1OJWA 2EHFA 2QY0A 4J38B 1OJYA 3ERBA 1FBRA 2B5ID 2UWNA 1HCCA 1G4GA 3IX0A 4YNXA 4AYIA 2RKYA 1QUBA 2RLQA 2W81A 1H2PP 1MD7A 1OJVA 1OK9A 1MD8A 4DJZA 3SW0X 4MUCA 3ZD2A 2XWBF 1E5GA 4AYEA 1GPZA 4F4OC 1CKLA 4CSYA 2RL0A 2LOJA 2RKZA 2KRIA 4KKDA 3GXEA 4LOSA 4B2SA 2WIIC 1OK2A 3CALA 3ZRZA 3OP8A 2CG7A 1TPNA 4IGDA 4JHSA 1H04P 2MCYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OED C;  2IZ3 A;  2EC3 A;  1ZJK A;  2CG6 A;  1QGB A;  2KMS A;  5HYP A;  4AYM A;  1Z92 B;  4ZH1 D;  1TPG A;  1NWV A;  1GHQ B;  1E8B A;  3M7P A;  2XRD A;  3RJ3 D;  1C1Z A;  1GKN A;  1LY2 A;  1HFH A;  5JPM G;  4WJG 2;  2IZ4 A;  2ERJ A;  4FXG G;  4K12 A;  4C16 A;  3KXV A;  2O39 C;  3T5O A;  3TVJ A;  1GKG A;  1U5M A;  3OXU D;  1O9A A;  5HZP B;  2MCZ A;  1G4F A;  3EJH A;  1PPQ A;  2YRA A;  2JGW A;  2W80 A;  4LOT A;  1OK1 A;  1E88 A;  1HFI A;  5I0Q B;  1UOT P;  1VVC A;  3MQL A;  2JRA A;  3INB C;  3KZJ A;  5HYT B;  1VVD A;  2A55 A;  3L89 M;  2XRB A;  1ELV A;  2CKU A;  3O8E B;  3IU3 I;  2JGX A;  2XWJ I;  4AYD A;  1OK3 A;  2G7I A;  4A5W B;  1Q3X A;  2YBY A;  2BZM A;  1TPM A;  1QO6 A;  3NFP I;  1H2Q P;  5FO8 C;  3GOV A;  4ONT D;  4PZ5 A;  5HYU B;  4B2R A;  3R62 A;  3ZD1 A;  1SRZ A;  2RLP A;  2V8E A;  1H03 P;  1SS2 A;  2XQW C;  1OJW A;  2EHF A;  2QY0 A;  4J38 B;  1OJY A;  3ERB A;  1FBR A;  2B5I D;  2UWN A;  1HCC A;  1G4G A;  3IX0 A;  4YNX A;  4AYI A;  2RKY A;  1QUB A;  2RLQ A;  2W81 A;  1H2P P;  1MD7 A;  1OJV A;  1OK9 A;  1MD8 A;  4DJZ A;  3SW0 X;  4MUC A;  3ZD2 A;  2XWB F;  1E5G A;  4AYE A;  1GPZ A;  4F4O C;  1CKL A;  4CSY A;  2RL0 A;  2LOJ A;  2RKZ A;  2KRI A;  4KKD A;  3GXE A;  4LOS A;  4B2S A;  2WII C;  1OK2 A;  3CAL A;  3ZRZ A;  3OP8 A;  2CG7 A;  1TPN A;  4IGD A;  4JHS A;  1H04 P;  2MCY A; 
#chains in the Genus database with same CATH topology
 4N7E A;  3OED C;  2IZ3 A;  2EC3 A;  1ZJK A;  2CG6 A;  1QGB A;  2KMS A;  5HYP A;  4AYM A;  1Z92 B;  4ZH1 D;  1TPG A;  1NWV A;  1GHQ B;  1E8B A;  3M7P A;  2XRD A;  3RJ3 D;  1C1Z A;  1GKN A;  1LY2 A;  1HFH A;  3WSX A;  5JPM G;  4WJG 2;  2IZ4 A;  2ERJ A;  4FXG G;  4K12 A;  4C16 A;  3KXV A;  2I2L A;  2O39 C;  3T5O A;  3TVJ A;  1GKG A;  1U5M A;  3OXU D;  1O9A A;  5HZP B;  2MCZ A;  1G4F A;  3EJH A;  1PPQ A;  2YRA A;  2JGW A;  2W80 A;  2ZYC A;  4LOT A;  1OK1 A;  1E88 A;  1HFI A;  2Y8S A;  1UOT P;  3ZLD A;  5I0Q B;  1VVC A;  3MQL A;  2JRA A;  3INB C;  3KZJ A;  5HYT B;  1VVD A;  2A55 A;  3L89 M;  2XRB A;  3VWO A;  1ELV A;  2CKU A;  3O8E B;  3IU3 I;  2JGX A;  2XWJ I;  4AYD A;  1OK3 A;  2G7I A;  4A5W B;  1Q3X A;  2YBY A;  2BZM A;  1TPM A;  1QO6 A;  3NFP I;  4PO7 A;  1H2Q P;  5FO8 C;  3GOV A;  4ONT D;  4PZ5 A;  2Y8T A;  5HYU B;  2X2Z A;  1RLH A;  4B2R A;  3R62 A;  3ZD1 A;  1SRZ A;  2RLP A;  2V8E A;  1H03 P;  1SS2 A;  2XQW C;  3NJA A;  1OJW A;  2EHF A;  2QY0 A;  4J38 B;  1OJY A;  3ERB A;  1FBR A;  2B5I D;  3F6K A;  3FGT A;  2UWN A;  3CI0 J;  3FGR A;  1HCC A;  4BWC A;  5DN5 A;  1G4G A;  3IX0 A;  4YNX A;  4AYI A;  2RKY A;  1QUB A;  2RLQ A;  2W81 A;  1H2P P;  1MD7 A;  1OJV A;  3WSY A;  1OK9 A;  1MD8 A;  4DJZ A;  3SW0 X;  4MUC A;  3ZD2 A;  2XWB F;  2Y8R A;  1E5G A;  4AYE A;  1GPZ A;  4F4O C;  1CKL A;  4CSY A;  2RL0 A;  2LOJ A;  2RKZ A;  2KRI A;  4KKD A;  3GXE A;  4LOS A;  4B2S A;  4MSL A;  2WII C;  3ZLE A;  1OK2 A;  3CAL A;  3ZRZ A;  3OP8 A;  2CG7 A;  3K3T A;  1TPN A;  4APL A;  4YIZ A;  4IGD A;  5DN4 A;  4JHS A;  1H04 P;  2MCY A; 
#chains in the Genus database with same CATH homology
 3OED C;  2IZ3 A;  2EC3 A;  1ZJK A;  2CG6 A;  1QGB A;  2KMS A;  5HYP A;  4AYM A;  1Z92 B;  4ZH1 D;  1TPG A;  1NWV A;  1GHQ B;  1E8B A;  3M7P A;  2XRD A;  3RJ3 D;  1C1Z A;  1GKN A;  1LY2 A;  1HFH A;  5JPM G;  4WJG 2;  2IZ4 A;  2ERJ A;  4FXG G;  4K12 A;  4C16 A;  3KXV A;  2O39 C;  3T5O A;  3TVJ A;  1GKG A;  1U5M A;  3OXU D;  1O9A A;  5HZP B;  2MCZ A;  1G4F A;  3EJH A;  1PPQ A;  2YRA A;  2JGW A;  2W80 A;  4LOT A;  1OK1 A;  1E88 A;  1HFI A;  5I0Q B;  1UOT P;  1VVC A;  3MQL A;  2JRA A;  3INB C;  3KZJ A;  5HYT B;  1VVD A;  2A55 A;  3L89 M;  2XRB A;  1ELV A;  2CKU A;  3O8E B;  3IU3 I;  2JGX A;  2XWJ I;  4AYD A;  1OK3 A;  2G7I A;  4A5W B;  1Q3X A;  2YBY A;  2BZM A;  1TPM A;  1QO6 A;  3NFP I;  1H2Q P;  5FO8 C;  3GOV A;  4ONT D;  4PZ5 A;  5HYU B;  4B2R A;  3R62 A;  3ZD1 A;  1SRZ A;  2RLP A;  2V8E A;  1H03 P;  1SS2 A;  2XQW C;  1OJW A;  2EHF A;  2QY0 A;  4J38 B;  1OJY A;  3ERB A;  1FBR A;  2B5I D;  2UWN A;  1HCC A;  1G4G A;  3IX0 A;  4YNX A;  4AYI A;  2RKY A;  1QUB A;  2RLQ A;  2W81 A;  1H2P P;  1MD7 A;  1OJV A;  1OK9 A;  1MD8 A;  4DJZ A;  3SW0 X;  4MUC A;  3ZD2 A;  2XWB F;  1E5G A;  4AYE A;  1GPZ A;  4F4O C;  1CKL A;  4CSY A;  2RL0 A;  2LOJ A;  2RKZ A;  2KRI A;  4KKD A;  3GXE A;  4LOS A;  4B2S A;  2WII C;  1OK2 A;  3CAL A;  3ZRZ A;  3OP8 A;  2CG7 A;  1TPN A;  4IGD A;  4JHS A;  1H04 P;  2MCY A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...