2G7KA

Structure of the light chain of botulinum neurotoxin, serotype a bound to small molecule inhibitors
Total Genus 129
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
129
sequence length
416
structure length
401
Chain Sequence
MFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHDVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPNRVFKVNTSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKAKSIIGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKVINRKTYLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNFNGQNTEINSRNFTRLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin type A
total genus 129
structure length 401
sequence length 416
chains with identical sequence B
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2006-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2g7kA00
3DDBA 3DDAA 2QN0A 3FFZA 4EL4A 1YVGA 1T3AA 3ZUSA 2G7KA 1ZL5A 1XTFA 3K3QB 3QW7A 1ZB7A 3QW5A 2A8AA 2NYYA 1XTGA 3QJ0A 3C89A 2G7QA 3QIZA 2NP0A 3QW8A 1S0DA 1Z7HA 4HEVA 3BWIA 4KS6A 3FIEA 2IMCA 1G9BA 2NZ9A 2FPQA 4EJ5A 5BQMA 2W2DA 1ZN3A 2IMAA 2IMBA 1ZL6A 3BTAA 2G7PA 3V0BB 1S0FA 4KUFA 1G9AA 3DS9A 3DEBA 2ISHA 3ZURA 2G7NA 1I1EA 1G9DA 1S0BA 1G9CA 1ZKXA 3BONA 3V0BA 3C88A 2ISEA 3ZUQA 3D3XA 1T3CA 1S0GA 3QW6A 1E1HA 1EPWA 5BQNA 4J1LA 1S0CA 3C8AA 2ETFA 3C8BA 3BOKA 4ZKTB 3V0AA 3QIXA 3V0AB 3BOOA 3DSEA 4ZJXA 4ELCA 1S0EA 1ZKWA 3VUOA 2A97A 2XHLA 3FIIA 4KTXA 2ILPA 1F82A 1F31A 3NF3A 2ISGA 3QIYA
chains in the Genus database with same CATH superfamily
3DDBA 3DDAA 2QN0A 3FFZA 4EL4A 1YVGA 1T3AA 3ZUSA 2G7KA 1ZL5A 1XTFA 3K3QB 3QW7A 1ZB7A 3QW5A 2A8AA 2NYYA 1XTGA 3QJ0A 3E11A 3C89A 2G7QA 3QIZA 2NP0A 3QW8A 1S0DA 1Z7HA 4HEVA 3BWIA 4KS6A 3FIEA 2IMCA 1G9BA 2NZ9A 2FPQA 4EJ5A 2YPTA 5BQMA 2W2DA 1ZN3A 2IMAA 3CQBA 2IMBA 1ZL6A 3BTAA 2G7PA 3V0BB 4JIXA 4JIUA 1S0FA 4KUFA 1G9AA 4AW6A 4IL3A 3DS9A 3DEBA 2ISHA 3ZURA 2G7NA 1I1EA 2EJQA 1G9DA 1S0BA 1G9CA 1ZKXA 3BONA 4QHFA 3V0BA 3C88A 2ISEA 3ZUQA 3D3XA 1T3CA 1S0GA 3QW6A 1E1HA 1EPWA 5BQNA 4J1LA 1S0CA 3C8AA 2ETFA 3C8BA 3BOKA 4ZKTB 3V0AA 3QIXA 3V0AB 3BOOA 3DSEA 4ZJXA 4ELCA 1S0EA 1ZKWA 3VUOA 2A97A 2XHLA 3FIIA 4KTXA 2ILPA 1F82A 1F31A 3NF3A 2ISGA 3QIYA
chains in the Genus database with same CATH topology
3DDBA 3DDAA 2QN0A 3FFZA 4EL4A 1YVGA 1T3AA 3ZUSA 2G7KA 1ZL5A 1XTFA 3K3QB 3QW7A 1ZB7A 3QW5A 2A8AA 2NYYA 1XTGA 3QJ0A 3C89A 2G7QA 3QIZA 2NP0A 3QW8A 1S0DA 1Z7HA 4HEVA 3BWIA 4KS6A 3FIEA 2IMCA 1G9BA 2NZ9A 2FPQA 4EJ5A 5BQMA 2W2DA 1ZN3A 2IMAA 2IMBA 1ZL6A 3BTAA 2G7PA 3V0BB 1S0FA 4KUFA 1G9AA 3DS9A 3DEBA 2ISHA 3ZURA 2G7NA 1I1EA 1G9DA 1S0BA 1G9CA 1ZKXA 3BONA 3V0BA 3C88A 2ISEA 3ZUQA 3D3XA 1T3CA 1S0GA 3QW6A 1E1HA 1EPWA 5BQNA 4J1LA 1S0CA 3C8AA 2ETFA 3C8BA 3BOKA 4ZKTB 3V0AA 3QIXA 3V0AB 3BOOA 3DSEA 4ZJXA 4ELCA 1S0EA 1ZKWA 3VUOA 2A97A 2XHLA 3FIIA 4KTXA 2ILPA 1F82A 1F31A 3NF3A 2ISGA 3QIYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DDB A;  3DDA A;  2QN0 A;  3FFZ A;  4EL4 A;  1YVG A;  1T3A A;  3ZUS A;  2G7K A;  1ZL5 A;  1XTF A;  3K3Q B;  3QW7 A;  1ZB7 A;  3QW5 A;  2A8A A;  2NYY A;  1XTG A;  3QJ0 A;  3C89 A;  2G7Q A;  3QIZ A;  2NP0 A;  3QW8 A;  1S0D A;  1Z7H A;  4HEV A;  3BWI A;  4KS6 A;  3FIE A;  2IMC A;  1G9B A;  2NZ9 A;  2FPQ A;  4EJ5 A;  5BQM A;  2W2D A;  1ZN3 A;  2IMA A;  2IMB A;  1ZL6 A;  3BTA A;  2G7P A;  3V0B B;  1S0F A;  4KUF A;  1G9A A;  3DS9 A;  3DEB A;  2ISH A;  3ZUR A;  2G7N A;  1I1E A;  1G9D A;  1S0B A;  1G9C A;  1ZKX A;  3BON A;  3V0B A;  3C88 A;  2ISE A;  3ZUQ A;  3D3X A;  1T3C A;  1S0G A;  3QW6 A;  1E1H A;  1EPW A;  5BQN A;  4J1L A;  1S0C A;  3C8A A;  2ETF A;  3C8B A;  3BOK A;  4ZKT B;  3V0A A;  3QIX A;  3V0A B;  3BOO A;  3DSE A;  4ZJX A;  4ELC A;  1S0E A;  1ZKW A;  3VUO A;  2A97 A;  2XHL A;  3FII A;  4KTX A;  2ILP A;  1F82 A;  1F31 A;  3NF3 A;  2ISG A;  3QIY A; 
#chains in the Genus database with same CATH topology
 3DDB A;  3DDA A;  2QN0 A;  3FFZ A;  4EL4 A;  1YVG A;  1T3A A;  3ZUS A;  2G7K A;  1ZL5 A;  1XTF A;  3K3Q B;  3QW7 A;  1ZB7 A;  3QW5 A;  2A8A A;  2NYY A;  1XTG A;  3QJ0 A;  3E11 A;  3C89 A;  2G7Q A;  3QIZ A;  2NP0 A;  3QW8 A;  1S0D A;  1Z7H A;  4HEV A;  3BWI A;  4KS6 A;  3FIE A;  2IMC A;  1G9B A;  2NZ9 A;  2FPQ A;  4EJ5 A;  2YPT A;  5BQM A;  2W2D A;  1ZN3 A;  2IMA A;  3CQB A;  2IMB A;  1ZL6 A;  3BTA A;  2G7P A;  3V0B B;  4JIX A;  4JIU A;  1S0F A;  4KUF A;  1G9A A;  4AW6 A;  4IL3 A;  3DS9 A;  3DEB A;  2ISH A;  3ZUR A;  2G7N A;  1I1E A;  2EJQ A;  1G9D A;  1S0B A;  1G9C A;  1ZKX A;  3BON A;  4QHF A;  3V0B A;  3C88 A;  2ISE A;  3ZUQ A;  3D3X A;  1T3C A;  1S0G A;  3QW6 A;  1E1H A;  1EPW A;  5BQN A;  4J1L A;  1S0C A;  3C8A A;  2ETF A;  3C8B A;  3BOK A;  4ZKT B;  3V0A A;  3QIX A;  3V0A B;  3BOO A;  3DSE A;  4ZJX A;  4ELC A;  1S0E A;  1ZKW A;  3VUO A;  2A97 A;  2XHL A;  3FII A;  4KTX A;  2ILP A;  1F82 A;  1F31 A;  3NF3 A;  2ISG A;  3QIY A; 
#chains in the Genus database with same CATH homology
 3DDB A;  3DDA A;  2QN0 A;  3FFZ A;  4EL4 A;  1YVG A;  1T3A A;  3ZUS A;  2G7K A;  1ZL5 A;  1XTF A;  3K3Q B;  3QW7 A;  1ZB7 A;  3QW5 A;  2A8A A;  2NYY A;  1XTG A;  3QJ0 A;  3C89 A;  2G7Q A;  3QIZ A;  2NP0 A;  3QW8 A;  1S0D A;  1Z7H A;  4HEV A;  3BWI A;  4KS6 A;  3FIE A;  2IMC A;  1G9B A;  2NZ9 A;  2FPQ A;  4EJ5 A;  5BQM A;  2W2D A;  1ZN3 A;  2IMA A;  2IMB A;  1ZL6 A;  3BTA A;  2G7P A;  3V0B B;  1S0F A;  4KUF A;  1G9A A;  3DS9 A;  3DEB A;  2ISH A;  3ZUR A;  2G7N A;  1I1E A;  1G9D A;  1S0B A;  1G9C A;  1ZKX A;  3BON A;  3V0B A;  3C88 A;  2ISE A;  3ZUQ A;  3D3X A;  1T3C A;  1S0G A;  3QW6 A;  1E1H A;  1EPW A;  5BQN A;  4J1L A;  1S0C A;  3C8A A;  2ETF A;  3C8B A;  3BOK A;  4ZKT B;  3V0A A;  3QIX A;  3V0A B;  3BOO A;  3DSE A;  4ZJX A;  4ELC A;  1S0E A;  1ZKW A;  3VUO A;  2A97 A;  2XHL A;  3FII A;  4KTX A;  2ILP A;  1F82 A;  1F31 A;  3NF3 A;  2ISG A;  3QIY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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