2G7NA

Structure of the light chain of botulinum neurotoxin serotype a bound to small molecule inhibitors
Total Genus 136
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
136
sequence length
419
structure length
415
Chain Sequence
MFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHDVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKAKSIIGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKVINRKTYLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNFNGQNTEINSRNFTRLKNFT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Light Chain of Botulinum Neurotoxin Serotype A bound to Small Molecule Inhibitors
rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin type A
total genus 136
structure length 415
sequence length 419
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2006-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2g7nA00
1F31A 1T3AA 2ETFA 1ZL5A 3FFZA 1S0BA 1G9AA 1S0DA 2NYYA 1E1HA 1XTFA 3NF3A 2IMBA 1I1EA 4ELCA 2FPQA 3K3QB 2G7QA 3ZURA 3QIZA 2ISHA 4KUFA 1S0EA 3QIXA 3C8AA 3DEBA 5BQNA 2NP0A 3DDAA 2G7PA 1G9DA 3C8BA 3VUOA 1F82A 2QN0A 2A97A 4ZJXA 3BWIA 4J1LA 4EL4A 2ISEA 1S0GA 4HEVA 3QW6A 1G9CA 1EPWA 3FIIA 3BOOA 3D3XA 1Z7HA 3QW8A 4EJ5A 1ZB7A 3QW5A 1S0CA 2W2DA 2G7NA 3BOKA 3V0AB 3QIYA 3ZUQA 3DDBA 1XTGA 3ZUSA 2IMAA 3C88A 3V0AA 4KTXA 2NZ9A 1ZN3A 1ZKXA 1ZL6A 3V0BB 2A8AA 3DS9A 2G7KA 1S0FA 3FIEA 1G9BA 4KS6A 3QW7A 3V0BA 1T3CA 2ISGA 3DSEA 2XHLA 4ZKTB 1YVGA 3C89A 3BONA 5BQMA 3BTAA 3QJ0A 2IMCA 2ILPA 1ZKWA
chains in the Genus database with same CATH superfamily
1F31A 1T3AA 2ETFA 4IL3A 1ZL5A 3FFZA 1S0BA 1G9AA 1S0DA 4AW6A 2NYYA 1E1HA 1XTFA 3NF3A 2IMBA 1I1EA 4ELCA 2FPQA 3K3QB 2G7QA 3ZURA 3QIZA 2ISHA 4KUFA 1S0EA 4JIXA 3QIXA 3C8AA 3DEBA 5BQNA 2NP0A 3DDAA 2G7PA 1G9DA 3C8BA 3VUOA 1F82A 2YPTA 2QN0A 2A97A 4ZJXA 3BWIA 4J1LA 4EL4A 2ISEA 1S0GA 4JIUA 3E11A 4HEVA 3QW6A 1G9CA 1EPWA 3FIIA 3BOOA 3D3XA 1Z7HA 3QW8A 4EJ5A 1ZB7A 3QW5A 1S0CA 2W2DA 2G7NA 3BOKA 3V0AB 3QIYA 3ZUQA 3DDBA 1XTGA 3ZUSA 2IMAA 3C88A 3V0AA 4KTXA 2NZ9A 1ZN3A 1ZKXA 1ZL6A 3V0BB 2A8AA 3DS9A 2G7KA 1S0FA 3FIEA 1G9BA 4KS6A 3QW7A 4QHFA 3V0BA 3CQBA 1T3CA 2ISGA 3DSEA 2XHLA 4ZKTB 1YVGA 3C89A 3BONA 5BQMA 3BTAA 3QJ0A 2EJQA 2IMCA 2ILPA 1ZKWA
chains in the Genus database with same CATH topology
1F31A 1T3AA 2ETFA 1ZL5A 3FFZA 1S0BA 1G9AA 1S0DA 2NYYA 1E1HA 1XTFA 3NF3A 2IMBA 1I1EA 4ELCA 2FPQA 3K3QB 2G7QA 3ZURA 3QIZA 2ISHA 4KUFA 1S0EA 3QIXA 3C8AA 3DEBA 5BQNA 2NP0A 3DDAA 2G7PA 1G9DA 3C8BA 3VUOA 1F82A 2QN0A 2A97A 4ZJXA 3BWIA 4J1LA 4EL4A 2ISEA 1S0GA 4HEVA 3QW6A 1G9CA 1EPWA 3FIIA 3BOOA 3D3XA 1Z7HA 3QW8A 4EJ5A 1ZB7A 3QW5A 1S0CA 2W2DA 2G7NA 3BOKA 3V0AB 3QIYA 3ZUQA 3DDBA 1XTGA 3ZUSA 2IMAA 3C88A 3V0AA 4KTXA 2NZ9A 1ZN3A 1ZKXA 1ZL6A 3V0BB 2A8AA 3DS9A 2G7KA 1S0FA 3FIEA 1G9BA 4KS6A 3QW7A 3V0BA 1T3CA 2ISGA 3DSEA 2XHLA 4ZKTB 1YVGA 3C89A 3BONA 5BQMA 3BTAA 3QJ0A 2IMCA 2ILPA 1ZKWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1F31 A;  1T3A A;  2ETF A;  1ZL5 A;  3FFZ A;  1S0B A;  1G9A A;  1S0D A;  2NYY A;  1E1H A;  1XTF A;  3NF3 A;  2IMB A;  1I1E A;  4ELC A;  2FPQ A;  3K3Q B;  2G7Q A;  3ZUR A;  3QIZ A;  2ISH A;  4KUF A;  1S0E A;  3QIX A;  3C8A A;  3DEB A;  5BQN A;  2NP0 A;  3DDA A;  2G7P A;  1G9D A;  3C8B A;  3VUO A;  1F82 A;  2QN0 A;  2A97 A;  4ZJX A;  3BWI A;  4J1L A;  4EL4 A;  2ISE A;  1S0G A;  4HEV A;  3QW6 A;  1G9C A;  1EPW A;  3FII A;  3BOO A;  3D3X A;  1Z7H A;  3QW8 A;  4EJ5 A;  1ZB7 A;  3QW5 A;  1S0C A;  2W2D A;  2G7N A;  3BOK A;  3V0A B;  3QIY A;  3ZUQ A;  3DDB A;  1XTG A;  3ZUS A;  2IMA A;  3C88 A;  3V0A A;  4KTX A;  2NZ9 A;  1ZN3 A;  1ZKX A;  1ZL6 A;  3V0B B;  2A8A A;  3DS9 A;  2G7K A;  1S0F A;  3FIE A;  1G9B A;  4KS6 A;  3QW7 A;  3V0B A;  1T3C A;  2ISG A;  3DSE A;  2XHL A;  4ZKT B;  1YVG A;  3C89 A;  3BON A;  5BQM A;  3BTA A;  3QJ0 A;  2IMC A;  2ILP A;  1ZKW A; 
#chains in the Genus database with same CATH topology
 1F31 A;  1T3A A;  2ETF A;  4IL3 A;  1ZL5 A;  3FFZ A;  1S0B A;  1G9A A;  1S0D A;  4AW6 A;  2NYY A;  1E1H A;  1XTF A;  3NF3 A;  2IMB A;  1I1E A;  4ELC A;  2FPQ A;  3K3Q B;  2G7Q A;  3ZUR A;  3QIZ A;  2ISH A;  4KUF A;  1S0E A;  4JIX A;  3QIX A;  3C8A A;  3DEB A;  5BQN A;  2NP0 A;  3DDA A;  2G7P A;  1G9D A;  3C8B A;  3VUO A;  1F82 A;  2YPT A;  2QN0 A;  2A97 A;  4ZJX A;  3BWI A;  4J1L A;  4EL4 A;  2ISE A;  1S0G A;  4JIU A;  3E11 A;  4HEV A;  3QW6 A;  1G9C A;  1EPW A;  3FII A;  3BOO A;  3D3X A;  1Z7H A;  3QW8 A;  4EJ5 A;  1ZB7 A;  3QW5 A;  1S0C A;  2W2D A;  2G7N A;  3BOK A;  3V0A B;  3QIY A;  3ZUQ A;  3DDB A;  1XTG A;  3ZUS A;  2IMA A;  3C88 A;  3V0A A;  4KTX A;  2NZ9 A;  1ZN3 A;  1ZKX A;  1ZL6 A;  3V0B B;  2A8A A;  3DS9 A;  2G7K A;  1S0F A;  3FIE A;  1G9B A;  4KS6 A;  3QW7 A;  4QHF A;  3V0B A;  3CQB A;  1T3C A;  2ISG A;  3DSE A;  2XHL A;  4ZKT B;  1YVG A;  3C89 A;  3BON A;  5BQM A;  3BTA A;  3QJ0 A;  2EJQ A;  2IMC A;  2ILP A;  1ZKW A; 
#chains in the Genus database with same CATH homology
 1F31 A;  1T3A A;  2ETF A;  1ZL5 A;  3FFZ A;  1S0B A;  1G9A A;  1S0D A;  2NYY A;  1E1H A;  1XTF A;  3NF3 A;  2IMB A;  1I1E A;  4ELC A;  2FPQ A;  3K3Q B;  2G7Q A;  3ZUR A;  3QIZ A;  2ISH A;  4KUF A;  1S0E A;  3QIX A;  3C8A A;  3DEB A;  5BQN A;  2NP0 A;  3DDA A;  2G7P A;  1G9D A;  3C8B A;  3VUO A;  1F82 A;  2QN0 A;  2A97 A;  4ZJX A;  3BWI A;  4J1L A;  4EL4 A;  2ISE A;  1S0G A;  4HEV A;  3QW6 A;  1G9C A;  1EPW A;  3FII A;  3BOO A;  3D3X A;  1Z7H A;  3QW8 A;  4EJ5 A;  1ZB7 A;  3QW5 A;  1S0C A;  2W2D A;  2G7N A;  3BOK A;  3V0A B;  3QIY A;  3ZUQ A;  3DDB A;  1XTG A;  3ZUS A;  2IMA A;  3C88 A;  3V0A A;  4KTX A;  2NZ9 A;  1ZN3 A;  1ZKX A;  1ZL6 A;  3V0B B;  2A8A A;  3DS9 A;  2G7K A;  1S0F A;  3FIE A;  1G9B A;  4KS6 A;  3QW7 A;  3V0B A;  1T3C A;  2ISG A;  3DSE A;  2XHL A;  4ZKT B;  1YVG A;  3C89 A;  3BON A;  5BQM A;  3BTA A;  3QJ0 A;  2IMC A;  2ILP A;  1ZKW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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