2G9YA

Structure of s102t e. coli alkaline phosphatase in presence of phosphate at 2.00 a resolution
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDTAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Trapping the tetrahedral intermediate in the alkaline phosphatase reaction by substitution of the active site serine with threonine.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 161
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2006-03-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2g9yA00
1AJDA 4UOPA 4UORA 4LRBA 2G9YA 5DLWA 5L0EA 1URAA 3IGZB 4LRFA 5EGEA 3SZZA 3IDDA 1ZEBA 5EGHA 3SZYA 3Q3QA 1O99A 4LR7A 4GTXA 1HDHA 1FSUA 1N2LA 2GSOA 1ANIA 3WAVA 1KH5A 1E3CP 4NWXA 2VQRA 2IUCB 1KHNA 1ALJA 3WAXA 3BDFA 1HQAA 1ELYA 2W5RA 2QZUA 3OT9A 4UPKA 4CXKA 1Y6VA 4KJGA 3UO0A 3UN2A 5HRTA 4GTYA 2GLQA 3CMRA 2XR9A 3BDGB 4ZG6A 2W5WA 2W5QA 5GRRA 3UN5A 4N7TA 4MIVA 4LR2A 1KHLA 1ELZA 4ZG9A 3TWZA 2D1GA 1ZEDA 2GA3A 2W8SA 2IFYA 4LREA 1KHKA 5LRMA 1ANJA 2W5TA 2W5VA 2ANHA 4TN0A 3NVLA 1ALHA 1ALKA 2X98A 1KH9A 4KM4A 3BDGA 1KH7A 1KH4A 3E2DA 5DLTA 1SHQA 2W8DA 2RH6A 4CYSA 3UN3A 5INHA 5K4PA 3MK0A 3WAWA 4LR8A 1E2SP 4QAXA 1ALIA 1N2KA 4GTWA 4MHXA 5KXAA 1O98A 1K7HA 3NKNA 3NKMA 5LRNA 1EW9A 1HJKA 1SHNA 3DYCA 5GOVA 1E1ZP 5C66A 3TX0A 3B5QA 3M7VA 3MK2A 1P49A 4UOOA 1AJBA 5DLVA 2XRGA 5L0BA 1AUKA 5AJ9A 3NKOA 4NWJA 3M8ZA 4GTZA 1EJJA 5IJQA 4FDIA 3LXQA 4UPHA 2W5SA 1ED9A 4LR9A 4KAYA 4FDJA 4ZGAA 1ED8A 4LRAA 3UNYA 3T02A 4CXUA 2IUCA 2W5XA 3NKRA 1AJCA 5IJSA 4KAVA 3WAYA 3TG0A 2ZKTA 1ELXA 4CYRA 1URBA 3BDHA 3NKQA 1EI6A 4UPIA 3M8WA 4LRCA 1EW8A 2GSNA 3T01A 3T00A 4UPLA 4B56A 5LQQA 3MK1A 5TJ3A 3ED4A 4YR1A 3DPCA 1B8JA 1E33P 5LIAA 3NKPA 1EW2A 1AJAA 4CXSA 3IGYB 4KJDA 3A52A 2GSUA 3KD8A 4ZG7A 4LQYA 4MY4A 3M8YA 1EQJA 1KHJA 4LRDA 3WBHA 1ZEFA 1Y7AA 5L0KA
chains in the Genus database with same CATH superfamily
1AJDA 4UOPA 4UORA 4LRBA 2G9YA 5DLWA 5L0EA 1URAA 3IGZB 4LRFA 5EGEA 3SZZA 3IDDA 1ZEBA 5EGHA 3SZYA 3Q3QA 1O99A 4LR7A 4GTXA 1HDHA 1FSUA 1N2LA 2GSOA 1ANIA 3WAVA 1KH5A 1E3CP 4NWXA 2VQRA 2IUCB 1KHNA 1ALJA 3WAXA 3BDFA 1HQAA 1ELYA 2W5RA 2QZUA 3OT9A 4UPKA 4CXKA 1Y6VA 4KJGA 3UO0A 3UN2A 5HRTA 4GTYA 2GLQA 3CMRA 2XR9A 3BDGB 4ZG6A 2W5WA 2W5QA 5GRRA 3UN5A 4N7TA 4MIVA 4LR2A 1KHLA 1ELZA 4ZG9A 3TWZA 2D1GA 1ZEDA 2GA3A 2W8SA 2IFYA 4LREA 1KHKA 5LRMA 1ANJA 2W5TA 2W5VA 2ANHA 4TN0A 3NVLA 1ALHA 1ALKA 2X98A 1KH9A 4KM4A 3BDGA 1KH7A 1KH4A 3E2DA 5DLTA 1SHQA 2W8DA 2RH6A 4CYSA 3UN3A 5INHA 5K4PA 3MK0A 3WAWA 4LR8A 1E2SP 4QAXA 1ALIA 1N2KA 4GTWA 4MHXA 5KXAA 1O98A 1K7HA 3NKNA 3NKMA 5LRNA 1EW9A 1HJKA 1SHNA 3DYCA 5GOVA 1E1ZP 5C66A 3TX0A 3B5QA 3M7VA 3MK2A 1P49A 4UOOA 1AJBA 5DLVA 2XRGA 5L0BA 1AUKA 5AJ9A 3NKOA 4NWJA 3M8ZA 4GTZA 1EJJA 5IJQA 4FDIA 3LXQA 4UPHA 2W5SA 1ED9A 4LR9A 4KAYA 4FDJA 4ZGAA 1ED8A 4LRAA 3UNYA 3T02A 4CXUA 2IUCA 2W5XA 3NKRA 1AJCA 5IJSA 4KAVA 3WAYA 3TG0A 2ZKTA 1ELXA 4CYRA 1URBA 3BDHA 3NKQA 1EI6A 4UPIA 3M8WA 4LRCA 1EW8A 2GSNA 3T01A 3T00A 4UPLA 4B56A 5LQQA 3MK1A 5TJ3A 3ED4A 4YR1A 3DPCA 1B8JA 1E33P 5LIAA 3NKPA 1EW2A 1AJAA 4CXSA 3IGYB 4KJDA 3A52A 2GSUA 3KD8A 4ZG7A 4LQYA 4MY4A 3M8YA 1EQJA 1KHJA 4LRDA 3WBHA 1ZEFA 1Y7AA 5L0KA
chains in the Genus database with same CATH topology
1AJDA 4UOPA 4UORA 4LRBA 2G9YA 5DLWA 5L0EA 1URAA 3IGZB 4LRFA 5EGEA 3SZZA 3IDDA 1ZEBA 5EGHA 3SZYA 3Q3QA 1O99A 4LR7A 4GTXA 1HDHA 1FSUA 1N2LA 2GSOA 1ANIA 3WAVA 1KH5A 1E3CP 4NWXA 2VQRA 2IUCB 1KHNA 1ALJA 3WAXA 3BDFA 1HQAA 1ELYA 2W5RA 2QZUA 3OT9A 4UPKA 4CXKA 1Y6VA 4KJGA 3UO0A 3UN2A 5HRTA 4GTYA 2GLQA 3CMRA 2XR9A 3BDGB 4ZG6A 2W5WA 2W5QA 5GRRA 3UN5A 4N7TA 4MIVA 4LR2A 1KHLA 1ELZA 4ZG9A 3TWZA 2D1GA 1ZEDA 2GA3A 2W8SA 2IFYA 4LREA 1KHKA 5LRMA 1ANJA 2W5TA 2W5VA 2ANHA 4TN0A 3NVLA 1ALHA 1ALKA 2X98A 1KH9A 4KM4A 3BDGA 1KH7A 1KH4A 3E2DA 5DLTA 1SHQA 2W8DA 2RH6A 4CYSA 3UN3A 5INHA 5K4PA 3MK0A 3WAWA 4LR8A 1E2SP 4QAXA 1ALIA 1N2KA 4GTWA 4MHXA 5KXAA 1O98A 1K7HA 3NKNA 3NKMA 5LRNA 1EW9A 1HJKA 1SHNA 3DYCA 5GOVA 1E1ZP 5C66A 3TX0A 3B5QA 3M7VA 3MK2A 1P49A 4UOOA 1AJBA 5DLVA 2XRGA 5L0BA 1AUKA 5AJ9A 3NKOA 4NWJA 3M8ZA 4GTZA 1EJJA 5IJQA 4FDIA 3LXQA 4UPHA 2W5SA 1ED9A 4LR9A 4KAYA 4FDJA 4ZGAA 1ED8A 4LRAA 3UNYA 3T02A 4CXUA 2IUCA 2W5XA 3NKRA 1AJCA 5IJSA 4KAVA 3WAYA 3TG0A 2ZKTA 1ELXA 4CYRA 1URBA 3BDHA 3NKQA 1EI6A 4UPIA 3M8WA 4LRCA 1EW8A 2GSNA 3T01A 3T00A 4UPLA 4B56A 5LQQA 3MK1A 5TJ3A 3ED4A 4YR1A 3DPCA 1B8JA 1E33P 5LIAA 3NKPA 1EW2A 1AJAA 4CXSA 3IGYB 4KJDA 3A52A 2GSUA 3KD8A 4ZG7A 4LQYA 4MY4A 3M8YA 1EQJA 1KHJA 4LRDA 3WBHA 1ZEFA 1Y7AA 5L0KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AJD A;  4UOP A;  4UOR A;  4LRB A;  2G9Y A;  5DLW A;  5L0E A;  1URA A;  3IGZ B;  4LRF A;  5EGE A;  3SZZ A;  3IDD A;  1ZEB A;  5EGH A;  3SZY A;  3Q3Q A;  1O99 A;  4LR7 A;  4GTX A;  1HDH A;  1FSU A;  1N2L A;  2GSO A;  1ANI A;  3WAV A;  1KH5 A;  1E3C P;  4NWX A;  2VQR A;  2IUC B;  1KHN A;  1ALJ A;  3WAX A;  3BDF A;  1HQA A;  1ELY A;  2W5R A;  2QZU A;  3OT9 A;  4UPK A;  4CXK A;  1Y6V A;  4KJG A;  3UO0 A;  3UN2 A;  5HRT A;  4GTY A;  2GLQ A;  3CMR A;  2XR9 A;  3BDG B;  4ZG6 A;  2W5W A;  2W5Q A;  5GRR A;  3UN5 A;  4N7T A;  4MIV A;  4LR2 A;  1KHL A;  1ELZ A;  4ZG9 A;  3TWZ A;  2D1G A;  1ZED A;  2GA3 A;  2W8S A;  2IFY A;  4LRE A;  1KHK A;  5LRM A;  1ANJ A;  2W5T A;  2W5V A;  2ANH A;  4TN0 A;  3NVL A;  1ALH A;  1ALK A;  2X98 A;  1KH9 A;  4KM4 A;  3BDG A;  1KH7 A;  1KH4 A;  3E2D A;  5DLT A;  1SHQ A;  2W8D A;  2RH6 A;  4CYS A;  3UN3 A;  5INH A;  5K4P A;  3MK0 A;  3WAW A;  4LR8 A;  1E2S P;  4QAX A;  1ALI A;  1N2K A;  4GTW A;  4MHX A;  5KXA A;  1O98 A;  1K7H A;  3NKN A;  3NKM A;  5LRN A;  1EW9 A;  1HJK A;  1SHN A;  3DYC A;  5GOV A;  1E1Z P;  5C66 A;  3TX0 A;  3B5Q A;  3M7V A;  3MK2 A;  1P49 A;  4UOO A;  1AJB A;  5DLV A;  2XRG A;  5L0B A;  1AUK A;  5AJ9 A;  3NKO A;  4NWJ A;  3M8Z A;  4GTZ A;  1EJJ A;  5IJQ A;  4FDI A;  3LXQ A;  4UPH A;  2W5S A;  1ED9 A;  4LR9 A;  4KAY A;  4FDJ A;  4ZGA A;  1ED8 A;  4LRA A;  3UNY A;  3T02 A;  4CXU A;  2IUC A;  2W5X A;  3NKR A;  1AJC A;  5IJS A;  4KAV A;  3WAY A;  3TG0 A;  2ZKT A;  1ELX A;  4CYR A;  1URB A;  3BDH A;  3NKQ A;  1EI6 A;  4UPI A;  3M8W A;  4LRC A;  1EW8 A;  2GSN A;  3T01 A;  3T00 A;  4UPL A;  4B56 A;  5LQQ A;  3MK1 A;  5TJ3 A;  3ED4 A;  4YR1 A;  3DPC A;  1B8J A;  1E33 P;  5LIA A;  3NKP A;  1EW2 A;  1AJA A;  4CXS A;  3IGY B;  4KJD A;  3A52 A;  2GSU A;  3KD8 A;  4ZG7 A;  4LQY A;  4MY4 A;  3M8Y A;  1EQJ A;  1KHJ A;  4LRD A;  3WBH A;  1ZEF A;  1Y7A A;  5L0K A; 
#chains in the Genus database with same CATH topology
 1AJD A;  4UOP A;  4UOR A;  4LRB A;  2G9Y A;  5DLW A;  5L0E A;  1URA A;  3IGZ B;  4LRF A;  5EGE A;  3SZZ A;  3IDD A;  1ZEB A;  5EGH A;  3SZY A;  3Q3Q A;  1O99 A;  4LR7 A;  4GTX A;  1HDH A;  1FSU A;  1N2L A;  2GSO A;  1ANI A;  3WAV A;  1KH5 A;  1E3C P;  4NWX A;  2VQR A;  2IUC B;  1KHN A;  1ALJ A;  3WAX A;  3BDF A;  1HQA A;  1ELY A;  2W5R A;  2QZU A;  3OT9 A;  4UPK A;  4CXK A;  1Y6V A;  4KJG A;  3UO0 A;  3UN2 A;  5HRT A;  4GTY A;  2GLQ A;  3CMR A;  2XR9 A;  3BDG B;  4ZG6 A;  2W5W A;  2W5Q A;  5GRR A;  3UN5 A;  4N7T A;  4MIV A;  4LR2 A;  1KHL A;  1ELZ A;  4ZG9 A;  3TWZ A;  2D1G A;  1ZED A;  2GA3 A;  2W8S A;  2IFY A;  4LRE A;  1KHK A;  5LRM A;  1ANJ A;  2W5T A;  2W5V A;  2ANH A;  4TN0 A;  3NVL A;  1ALH A;  1ALK A;  2X98 A;  1KH9 A;  4KM4 A;  3BDG A;  1KH7 A;  1KH4 A;  3E2D A;  5DLT A;  1SHQ A;  2W8D A;  2RH6 A;  4CYS A;  3UN3 A;  5INH A;  5K4P A;  3MK0 A;  3WAW A;  4LR8 A;  1E2S P;  4QAX A;  1ALI A;  1N2K A;  4GTW A;  4MHX A;  5KXA A;  1O98 A;  1K7H A;  3NKN A;  3NKM A;  5LRN A;  1EW9 A;  1HJK A;  1SHN A;  3DYC A;  5GOV A;  1E1Z P;  5C66 A;  3TX0 A;  3B5Q A;  3M7V A;  3MK2 A;  1P49 A;  4UOO A;  1AJB A;  5DLV A;  2XRG A;  5L0B A;  1AUK A;  5AJ9 A;  3NKO A;  4NWJ A;  3M8Z A;  4GTZ A;  1EJJ A;  5IJQ A;  4FDI A;  3LXQ A;  4UPH A;  2W5S A;  1ED9 A;  4LR9 A;  4KAY A;  4FDJ A;  4ZGA A;  1ED8 A;  4LRA A;  3UNY A;  3T02 A;  4CXU A;  2IUC A;  2W5X A;  3NKR A;  1AJC A;  5IJS A;  4KAV A;  3WAY A;  3TG0 A;  2ZKT A;  1ELX A;  4CYR A;  1URB A;  3BDH A;  3NKQ A;  1EI6 A;  4UPI A;  3M8W A;  4LRC A;  1EW8 A;  2GSN A;  3T01 A;  3T00 A;  4UPL A;  4B56 A;  5LQQ A;  3MK1 A;  5TJ3 A;  3ED4 A;  4YR1 A;  3DPC A;  1B8J A;  1E33 P;  5LIA A;  3NKP A;  1EW2 A;  1AJA A;  4CXS A;  3IGY B;  4KJD A;  3A52 A;  2GSU A;  3KD8 A;  4ZG7 A;  4LQY A;  4MY4 A;  3M8Y A;  1EQJ A;  1KHJ A;  4LRD A;  3WBH A;  1ZEF A;  1Y7A A;  5L0K A; 
#chains in the Genus database with same CATH homology
 1AJD A;  4UOP A;  4UOR A;  4LRB A;  2G9Y A;  5DLW A;  5L0E A;  1URA A;  3IGZ B;  4LRF A;  5EGE A;  3SZZ A;  3IDD A;  1ZEB A;  5EGH A;  3SZY A;  3Q3Q A;  1O99 A;  4LR7 A;  4GTX A;  1HDH A;  1FSU A;  1N2L A;  2GSO A;  1ANI A;  3WAV A;  1KH5 A;  1E3C P;  4NWX A;  2VQR A;  2IUC B;  1KHN A;  1ALJ A;  3WAX A;  3BDF A;  1HQA A;  1ELY A;  2W5R A;  2QZU A;  3OT9 A;  4UPK A;  4CXK A;  1Y6V A;  4KJG A;  3UO0 A;  3UN2 A;  5HRT A;  4GTY A;  2GLQ A;  3CMR A;  2XR9 A;  3BDG B;  4ZG6 A;  2W5W A;  2W5Q A;  5GRR A;  3UN5 A;  4N7T A;  4MIV A;  4LR2 A;  1KHL A;  1ELZ A;  4ZG9 A;  3TWZ A;  2D1G A;  1ZED A;  2GA3 A;  2W8S A;  2IFY A;  4LRE A;  1KHK A;  5LRM A;  1ANJ A;  2W5T A;  2W5V A;  2ANH A;  4TN0 A;  3NVL A;  1ALH A;  1ALK A;  2X98 A;  1KH9 A;  4KM4 A;  3BDG A;  1KH7 A;  1KH4 A;  3E2D A;  5DLT A;  1SHQ A;  2W8D A;  2RH6 A;  4CYS A;  3UN3 A;  5INH A;  5K4P A;  3MK0 A;  3WAW A;  4LR8 A;  1E2S P;  4QAX A;  1ALI A;  1N2K A;  4GTW A;  4MHX A;  5KXA A;  1O98 A;  1K7H A;  3NKN A;  3NKM A;  5LRN A;  1EW9 A;  1HJK A;  1SHN A;  3DYC A;  5GOV A;  1E1Z P;  5C66 A;  3TX0 A;  3B5Q A;  3M7V A;  3MK2 A;  1P49 A;  4UOO A;  1AJB A;  5DLV A;  2XRG A;  5L0B A;  1AUK A;  5AJ9 A;  3NKO A;  4NWJ A;  3M8Z A;  4GTZ A;  1EJJ A;  5IJQ A;  4FDI A;  3LXQ A;  4UPH A;  2W5S A;  1ED9 A;  4LR9 A;  4KAY A;  4FDJ A;  4ZGA A;  1ED8 A;  4LRA A;  3UNY A;  3T02 A;  4CXU A;  2IUC A;  2W5X A;  3NKR A;  1AJC A;  5IJS A;  4KAV A;  3WAY A;  3TG0 A;  2ZKT A;  1ELX A;  4CYR A;  1URB A;  3BDH A;  3NKQ A;  1EI6 A;  4UPI A;  3M8W A;  4LRC A;  1EW8 A;  2GSN A;  3T01 A;  3T00 A;  4UPL A;  4B56 A;  5LQQ A;  3MK1 A;  5TJ3 A;  3ED4 A;  4YR1 A;  3DPC A;  1B8J A;  1E33 P;  5LIA A;  3NKP A;  1EW2 A;  1AJA A;  4CXS A;  3IGY B;  4KJD A;  3A52 A;  2GSU A;  3KD8 A;  4ZG7 A;  4LQY A;  4MY4 A;  3M8Y A;  1EQJ A;  1KHJ A;  4LRD A;  3WBH A;  1ZEF A;  1Y7A A;  5L0K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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