2G9YA

Structure of s102t e. coli alkaline phosphatase in presence of phosphate at 2.00 a resolution
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDTAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Trapping the tetrahedral intermediate in the alkaline phosphatase reaction by substitution of the active site serine with threonine.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Alkaline phosphatase
total genus 161
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2006-03-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2g9yA00
2RH6A 4B56A 5INHA 2XRGA 2QZUA 3BDGB 4MIVA 4ZG7A 3ED4A 3IDDA 1KH4A 1EI6A 3SZZA 2GA3A 3M8ZA 5GOVA 1ZEFA 1KH7A 3M8YA 4LRBA 2W5RA 1E3CP 4LRCA 4UPKA 5TJ3A 4N7TA 1KH9A 2ANHA 4QAXA 4CXUA 2W5TA 1E1ZP 4LR9A 4ZG9A 4LR7A 1EQJA 4TN0A 5IJSA 3NKQA 3UN5A 1K7HA 2GLQA 1KH5A 1Y7AA 3MK1A 4UPIA 2D1GA 1N2KA 1KHJA 3OT9A 4LQYA 3IGZB 3NKNA 4KAYA 3IGYB 3MK0A 1ALIA 5HRTA 3T01A 2W8DA 1HJKA 1ELZA 4GTYA 5KXAA 1O99A 5DLWA 1P49A 1E33P 3WAYA 3NKPA 1ELYA 4CXKA 3SZYA 4YR1A 1KHKA 2GSNA 3M7VA 5LIAA 4LR2A 3NKRA 5GRRA 4UOPA 5IJQA 1ED8A 1KHNA 1URAA 3WAVA 5EGHA 1FSUA 4CYSA 1ZEDA 3TX0A 5LRMA 3UN3A 5L0EA 4CXSA 3UNYA 4CYRA 2W8SA 1SHQA 4UPLA 5L0BA 3A52A 1ALJA 1EW8A 1N2LA 3NVLA 2IFYA 3B5QA 5C66A 2ZKTA 4FDJA 3TWZA 1AJCA 3T02A 5DLTA 4NWXA 1AJAA 4GTWA 2X98A 1HQAA 5DLVA 3E2DA 5L0KA 1AJBA 4LRDA 3WBHA 1SHNA 3KD8A 4GTXA 4MHXA 3WAXA 4ZGAA 4UORA 2VQRA 2GSOA 3DPCA 4ZG6A 2G9YA 3T00A 3DYCA 5K4PA 2W5WA 2W5SA 3BDFA 1URBA 4KAVA 1AUKA 1EJJA 3UN2A 4UOOA 3Q3QA 4KJDA 1EW2A 1ANJA 4KM4A 4LR8A 5LQQA 1KHLA 2IUCB 1ALHA 1ALKA 2W5XA 3WAWA 3CMRA 2GSUA 1ZEBA 5LRNA 1E2SP 3BDHA 3NKMA 1HDHA 1O98A 2XR9A 1ED9A 4LRFA 4LREA 1Y6VA 3NKOA 5AJ9A 1AJDA 4MY4A 2W5VA 4UPHA 3M8WA 2IUCA 3MK2A 3BDGA 4GTZA 2W5QA 4FDIA 1B8JA 1ELXA 4LRAA 3TG0A 5EGEA 3UO0A 1ANIA 4KJGA 4NWJA 1EW9A 3LXQA
chains in the Genus database with same CATH superfamily
2RH6A 4B56A 5INHA 2XRGA 2QZUA 3BDGB 4MIVA 4ZG7A 3ED4A 3IDDA 1KH4A 1EI6A 3SZZA 2GA3A 3M8ZA 5GOVA 1ZEFA 1KH7A 3M8YA 4LRBA 2W5RA 1E3CP 4LRCA 4UPKA 5TJ3A 4N7TA 1KH9A 2ANHA 4QAXA 4CXUA 2W5TA 1E1ZP 4LR9A 4ZG9A 4LR7A 1EQJA 4TN0A 5IJSA 3NKQA 3UN5A 1K7HA 2GLQA 1KH5A 1Y7AA 3MK1A 4UPIA 2D1GA 1N2KA 1KHJA 3OT9A 4LQYA 3IGZB 3NKNA 4KAYA 3IGYB 3MK0A 1ALIA 5HRTA 3T01A 2W8DA 1HJKA 1ELZA 4GTYA 5KXAA 1O99A 5DLWA 1P49A 1E33P 3WAYA 3NKPA 1ELYA 4CXKA 3SZYA 4YR1A 1KHKA 2GSNA 3M7VA 5LIAA 4LR2A 3NKRA 5GRRA 4UOPA 5IJQA 1ED8A 1KHNA 1URAA 3WAVA 5EGHA 1FSUA 4CYSA 1ZEDA 3TX0A 5LRMA 3UN3A 5L0EA 4CXSA 3UNYA 4CYRA 2W8SA 1SHQA 4UPLA 5L0BA 3A52A 1ALJA 1EW8A 1N2LA 3NVLA 2IFYA 3B5QA 5C66A 2ZKTA 4FDJA 3TWZA 1AJCA 3T02A 5DLTA 4NWXA 1AJAA 4GTWA 2X98A 1HQAA 5DLVA 3E2DA 5L0KA 1AJBA 4LRDA 3WBHA 1SHNA 3KD8A 4GTXA 4MHXA 3WAXA 4ZGAA 4UORA 2VQRA 2GSOA 3DPCA 4ZG6A 2G9YA 3T00A 3DYCA 5K4PA 2W5WA 2W5SA 3BDFA 1URBA 4KAVA 1AUKA 1EJJA 3UN2A 4UOOA 3Q3QA 4KJDA 1EW2A 1ANJA 4KM4A 4LR8A 5LQQA 1KHLA 2IUCB 1ALHA 1ALKA 2W5XA 3WAWA 3CMRA 2GSUA 1ZEBA 5LRNA 1E2SP 3BDHA 3NKMA 1HDHA 1O98A 2XR9A 1ED9A 4LRFA 4LREA 1Y6VA 3NKOA 5AJ9A 1AJDA 4MY4A 2W5VA 4UPHA 3M8WA 2IUCA 3MK2A 3BDGA 4GTZA 2W5QA 4FDIA 1B8JA 1ELXA 4LRAA 3TG0A 5EGEA 3UO0A 1ANIA 4KJGA 4NWJA 1EW9A 3LXQA
chains in the Genus database with same CATH topology
2RH6A 4B56A 5INHA 2XRGA 2QZUA 3BDGB 4MIVA 4ZG7A 3ED4A 3IDDA 1KH4A 1EI6A 3SZZA 2GA3A 3M8ZA 5GOVA 1ZEFA 1KH7A 3M8YA 4LRBA 2W5RA 1E3CP 4LRCA 4UPKA 5TJ3A 4N7TA 1KH9A 2ANHA 4QAXA 4CXUA 2W5TA 1E1ZP 4LR9A 4ZG9A 4LR7A 1EQJA 4TN0A 5IJSA 3NKQA 3UN5A 1K7HA 2GLQA 1KH5A 1Y7AA 3MK1A 4UPIA 2D1GA 1N2KA 1KHJA 3OT9A 4LQYA 3IGZB 3NKNA 4KAYA 3IGYB 3MK0A 1ALIA 5HRTA 3T01A 2W8DA 1HJKA 1ELZA 4GTYA 5KXAA 1O99A 5DLWA 1P49A 1E33P 3WAYA 3NKPA 1ELYA 4CXKA 3SZYA 4YR1A 1KHKA 2GSNA 3M7VA 5LIAA 4LR2A 3NKRA 5GRRA 4UOPA 5IJQA 1ED8A 1KHNA 1URAA 3WAVA 5EGHA 1FSUA 4CYSA 1ZEDA 3TX0A 5LRMA 3UN3A 5L0EA 4CXSA 3UNYA 4CYRA 2W8SA 1SHQA 4UPLA 5L0BA 3A52A 1ALJA 1EW8A 1N2LA 3NVLA 2IFYA 3B5QA 5C66A 2ZKTA 4FDJA 3TWZA 1AJCA 3T02A 5DLTA 4NWXA 1AJAA 4GTWA 2X98A 1HQAA 5DLVA 3E2DA 5L0KA 1AJBA 4LRDA 3WBHA 1SHNA 3KD8A 4GTXA 4MHXA 3WAXA 4ZGAA 4UORA 2VQRA 2GSOA 3DPCA 4ZG6A 2G9YA 3T00A 3DYCA 5K4PA 2W5WA 2W5SA 3BDFA 1URBA 4KAVA 1AUKA 1EJJA 3UN2A 4UOOA 3Q3QA 4KJDA 1EW2A 1ANJA 4KM4A 4LR8A 5LQQA 1KHLA 2IUCB 1ALHA 1ALKA 2W5XA 3WAWA 3CMRA 2GSUA 1ZEBA 5LRNA 1E2SP 3BDHA 3NKMA 1HDHA 1O98A 2XR9A 1ED9A 4LRFA 4LREA 1Y6VA 3NKOA 5AJ9A 1AJDA 4MY4A 2W5VA 4UPHA 3M8WA 2IUCA 3MK2A 3BDGA 4GTZA 2W5QA 4FDIA 1B8JA 1ELXA 4LRAA 3TG0A 5EGEA 3UO0A 1ANIA 4KJGA 4NWJA 1EW9A 3LXQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RH6 A;  4B56 A;  5INH A;  2XRG A;  2QZU A;  3BDG B;  4MIV A;  4ZG7 A;  3ED4 A;  3IDD A;  1KH4 A;  1EI6 A;  3SZZ A;  2GA3 A;  3M8Z A;  5GOV A;  1ZEF A;  1KH7 A;  3M8Y A;  4LRB A;  2W5R A;  1E3C P;  4LRC A;  4UPK A;  5TJ3 A;  4N7T A;  1KH9 A;  2ANH A;  4QAX A;  4CXU A;  2W5T A;  1E1Z P;  4LR9 A;  4ZG9 A;  4LR7 A;  1EQJ A;  4TN0 A;  5IJS A;  3NKQ A;  3UN5 A;  1K7H A;  2GLQ A;  1KH5 A;  1Y7A A;  3MK1 A;  4UPI A;  2D1G A;  1N2K A;  1KHJ A;  3OT9 A;  4LQY A;  3IGZ B;  3NKN A;  4KAY A;  3IGY B;  3MK0 A;  1ALI A;  5HRT A;  3T01 A;  2W8D A;  1HJK A;  1ELZ A;  4GTY A;  5KXA A;  1O99 A;  5DLW A;  1P49 A;  1E33 P;  3WAY A;  3NKP A;  1ELY A;  4CXK A;  3SZY A;  4YR1 A;  1KHK A;  2GSN A;  3M7V A;  5LIA A;  4LR2 A;  3NKR A;  5GRR A;  4UOP A;  5IJQ A;  1ED8 A;  1KHN A;  1URA A;  3WAV A;  5EGH A;  1FSU A;  4CYS A;  1ZED A;  3TX0 A;  5LRM A;  3UN3 A;  5L0E A;  4CXS A;  3UNY A;  4CYR A;  2W8S A;  1SHQ A;  4UPL A;  5L0B A;  3A52 A;  1ALJ A;  1EW8 A;  1N2L A;  3NVL A;  2IFY A;  3B5Q A;  5C66 A;  2ZKT A;  4FDJ A;  3TWZ A;  1AJC A;  3T02 A;  5DLT A;  4NWX A;  1AJA A;  4GTW A;  2X98 A;  1HQA A;  5DLV A;  3E2D A;  5L0K A;  1AJB A;  4LRD A;  3WBH A;  1SHN A;  3KD8 A;  4GTX A;  4MHX A;  3WAX A;  4ZGA A;  4UOR A;  2VQR A;  2GSO A;  3DPC A;  4ZG6 A;  2G9Y A;  3T00 A;  3DYC A;  5K4P A;  2W5W A;  2W5S A;  3BDF A;  1URB A;  4KAV A;  1AUK A;  1EJJ A;  3UN2 A;  4UOO A;  3Q3Q A;  4KJD A;  1EW2 A;  1ANJ A;  4KM4 A;  4LR8 A;  5LQQ A;  1KHL A;  2IUC B;  1ALH A;  1ALK A;  2W5X A;  3WAW A;  3CMR A;  2GSU A;  1ZEB A;  5LRN A;  1E2S P;  3BDH A;  3NKM A;  1HDH A;  1O98 A;  2XR9 A;  1ED9 A;  4LRF A;  4LRE A;  1Y6V A;  3NKO A;  5AJ9 A;  1AJD A;  4MY4 A;  2W5V A;  4UPH A;  3M8W A;  2IUC A;  3MK2 A;  3BDG A;  4GTZ A;  2W5Q A;  4FDI A;  1B8J A;  1ELX A;  4LRA A;  3TG0 A;  5EGE A;  3UO0 A;  1ANI A;  4KJG A;  4NWJ A;  1EW9 A;  3LXQ A; 
#chains in the Genus database with same CATH topology
 2RH6 A;  4B56 A;  5INH A;  2XRG A;  2QZU A;  3BDG B;  4MIV A;  4ZG7 A;  3ED4 A;  3IDD A;  1KH4 A;  1EI6 A;  3SZZ A;  2GA3 A;  3M8Z A;  5GOV A;  1ZEF A;  1KH7 A;  3M8Y A;  4LRB A;  2W5R A;  1E3C P;  4LRC A;  4UPK A;  5TJ3 A;  4N7T A;  1KH9 A;  2ANH A;  4QAX A;  4CXU A;  2W5T A;  1E1Z P;  4LR9 A;  4ZG9 A;  4LR7 A;  1EQJ A;  4TN0 A;  5IJS A;  3NKQ A;  3UN5 A;  1K7H A;  2GLQ A;  1KH5 A;  1Y7A A;  3MK1 A;  4UPI A;  2D1G A;  1N2K A;  1KHJ A;  3OT9 A;  4LQY A;  3IGZ B;  3NKN A;  4KAY A;  3IGY B;  3MK0 A;  1ALI A;  5HRT A;  3T01 A;  2W8D A;  1HJK A;  1ELZ A;  4GTY A;  5KXA A;  1O99 A;  5DLW A;  1P49 A;  1E33 P;  3WAY A;  3NKP A;  1ELY A;  4CXK A;  3SZY A;  4YR1 A;  1KHK A;  2GSN A;  3M7V A;  5LIA A;  4LR2 A;  3NKR A;  5GRR A;  4UOP A;  5IJQ A;  1ED8 A;  1KHN A;  1URA A;  3WAV A;  5EGH A;  1FSU A;  4CYS A;  1ZED A;  3TX0 A;  5LRM A;  3UN3 A;  5L0E A;  4CXS A;  3UNY A;  4CYR A;  2W8S A;  1SHQ A;  4UPL A;  5L0B A;  3A52 A;  1ALJ A;  1EW8 A;  1N2L A;  3NVL A;  2IFY A;  3B5Q A;  5C66 A;  2ZKT A;  4FDJ A;  3TWZ A;  1AJC A;  3T02 A;  5DLT A;  4NWX A;  1AJA A;  4GTW A;  2X98 A;  1HQA A;  5DLV A;  3E2D A;  5L0K A;  1AJB A;  4LRD A;  3WBH A;  1SHN A;  3KD8 A;  4GTX A;  4MHX A;  3WAX A;  4ZGA A;  4UOR A;  2VQR A;  2GSO A;  3DPC A;  4ZG6 A;  2G9Y A;  3T00 A;  3DYC A;  5K4P A;  2W5W A;  2W5S A;  3BDF A;  1URB A;  4KAV A;  1AUK A;  1EJJ A;  3UN2 A;  4UOO A;  3Q3Q A;  4KJD A;  1EW2 A;  1ANJ A;  4KM4 A;  4LR8 A;  5LQQ A;  1KHL A;  2IUC B;  1ALH A;  1ALK A;  2W5X A;  3WAW A;  3CMR A;  2GSU A;  1ZEB A;  5LRN A;  1E2S P;  3BDH A;  3NKM A;  1HDH A;  1O98 A;  2XR9 A;  1ED9 A;  4LRF A;  4LRE A;  1Y6V A;  3NKO A;  5AJ9 A;  1AJD A;  4MY4 A;  2W5V A;  4UPH A;  3M8W A;  2IUC A;  3MK2 A;  3BDG A;  4GTZ A;  2W5Q A;  4FDI A;  1B8J A;  1ELX A;  4LRA A;  3TG0 A;  5EGE A;  3UO0 A;  1ANI A;  4KJG A;  4NWJ A;  1EW9 A;  3LXQ A; 
#chains in the Genus database with same CATH homology
 2RH6 A;  4B56 A;  5INH A;  2XRG A;  2QZU A;  3BDG B;  4MIV A;  4ZG7 A;  3ED4 A;  3IDD A;  1KH4 A;  1EI6 A;  3SZZ A;  2GA3 A;  3M8Z A;  5GOV A;  1ZEF A;  1KH7 A;  3M8Y A;  4LRB A;  2W5R A;  1E3C P;  4LRC A;  4UPK A;  5TJ3 A;  4N7T A;  1KH9 A;  2ANH A;  4QAX A;  4CXU A;  2W5T A;  1E1Z P;  4LR9 A;  4ZG9 A;  4LR7 A;  1EQJ A;  4TN0 A;  5IJS A;  3NKQ A;  3UN5 A;  1K7H A;  2GLQ A;  1KH5 A;  1Y7A A;  3MK1 A;  4UPI A;  2D1G A;  1N2K A;  1KHJ A;  3OT9 A;  4LQY A;  3IGZ B;  3NKN A;  4KAY A;  3IGY B;  3MK0 A;  1ALI A;  5HRT A;  3T01 A;  2W8D A;  1HJK A;  1ELZ A;  4GTY A;  5KXA A;  1O99 A;  5DLW A;  1P49 A;  1E33 P;  3WAY A;  3NKP A;  1ELY A;  4CXK A;  3SZY A;  4YR1 A;  1KHK A;  2GSN A;  3M7V A;  5LIA A;  4LR2 A;  3NKR A;  5GRR A;  4UOP A;  5IJQ A;  1ED8 A;  1KHN A;  1URA A;  3WAV A;  5EGH A;  1FSU A;  4CYS A;  1ZED A;  3TX0 A;  5LRM A;  3UN3 A;  5L0E A;  4CXS A;  3UNY A;  4CYR A;  2W8S A;  1SHQ A;  4UPL A;  5L0B A;  3A52 A;  1ALJ A;  1EW8 A;  1N2L A;  3NVL A;  2IFY A;  3B5Q A;  5C66 A;  2ZKT A;  4FDJ A;  3TWZ A;  1AJC A;  3T02 A;  5DLT A;  4NWX A;  1AJA A;  4GTW A;  2X98 A;  1HQA A;  5DLV A;  3E2D A;  5L0K A;  1AJB A;  4LRD A;  3WBH A;  1SHN A;  3KD8 A;  4GTX A;  4MHX A;  3WAX A;  4ZGA A;  4UOR A;  2VQR A;  2GSO A;  3DPC A;  4ZG6 A;  2G9Y A;  3T00 A;  3DYC A;  5K4P A;  2W5W A;  2W5S A;  3BDF A;  1URB A;  4KAV A;  1AUK A;  1EJJ A;  3UN2 A;  4UOO A;  3Q3Q A;  4KJD A;  1EW2 A;  1ANJ A;  4KM4 A;  4LR8 A;  5LQQ A;  1KHL A;  2IUC B;  1ALH A;  1ALK A;  2W5X A;  3WAW A;  3CMR A;  2GSU A;  1ZEB A;  5LRN A;  1E2S P;  3BDH A;  3NKM A;  1HDH A;  1O98 A;  2XR9 A;  1ED9 A;  4LRF A;  4LRE A;  1Y6V A;  3NKO A;  5AJ9 A;  1AJD A;  4MY4 A;  2W5V A;  4UPH A;  3M8W A;  2IUC A;  3MK2 A;  3BDG A;  4GTZ A;  2W5Q A;  4FDI A;  1B8J A;  1ELX A;  4LRA A;  3TG0 A;  5EGE A;  3UO0 A;  1ANI A;  4KJG A;  4NWJ A;  1EW9 A;  3LXQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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