2GA3A

Structure of s102t e. coli alkaline phosphatase-phosphate intermediate at 2.20a resolution
Total Genus 165
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
165
Knots found
sequence length
449
structure length
448
Chain Sequence
b'TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title Trapping the tetrahedral intermediate in the alkaline phosphatase reaction by substitution of the active site serine with threonine.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 165
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2006-03-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2ga3A00
5LQQA 1HJKA 4LRDA 3SZYA 3NKNA 2W8DA 4FDJA 4LR7A 1ANIA 1HQAA 3BDGA 2ZKTA 3NKPA 5LIAA 1EI6A 1E3CP 3TX0A 1KHLA 4LRBA 2W5TA 4NWJA 1N2LA 4LQYA 1HDHA 4GTYA 3BDFA 1KH7A 2W8SA 2W5RA 1ALKA 1KHNA 4B56A 1KH5A 4QAXA 2W5WA 1KHKA 1Y7AA 4N7TA 1O98A 4YR1A 2W5QA 1B8JA 5TJ3A 4KJGA 4LRFA 2QZUA 5EGEA 2ANHA 4CXKA 3UO0A 1AJCA 1SHQA 1ED9A 2IUCA 2W5SA 4UPLA 3OT9A 3UN2A 1ED8A 5DLWA 3SZZA 4MY4A 1AJDA 1AUKA 3WAWA 1AJAA 1Y6VA 3WAYA 4ZGAA 1ALIA 1K7HA 4UORA 5IJQA 1KHJA 4CXUA 5DLTA 4GTWA 4FDIA 3MK2A 3IGZB 5C66A 1EQJA 1ZEBA 2XR9A 3NKRA 3NKQA 3UN3A 1URAA 2D1GA 4NWXA 1ZEFA 2GSNA 2RH6A 3E2DA 4KJDA 1EW8A 1KH9A 3TG0A 1N2KA 1URBA 3WBHA 4LR9A 5L0KA 1EW9A 5GOVA 4CYRA 3IDDA 2G9YA 5K4PA 3ED4A 1ALJA 4LR8A 3NKOA 5KXAA 1FSUA 1P49A 3LXQA 2W5XA 1E33P 1EW2A 1SHNA 3IGYB 3CMRA 2GSOA 3BDHA 5IJSA 3T02A 5L0EA 2IFYA 4MHXA 4MIVA 3UNYA 4LRAA 4LR2A 2W5VA 1ALHA 3DPCA 4UOPA 3KD8A 4TN0A 1E2SP 5GRRA 4CXSA 4LREA 4GTZA 4UOOA 3MK1A 3NKMA 3NVLA 3TWZA 1ELZA 2X98A 2XRGA 4KAYA 3M8WA 4KM4A 5L0BA 2IUCB 3WAXA 3T01A 4UPIA 2GA3A 3M8YA 3T00A 3DYCA 3BDGB 2GLQA 1EJJA 4ZG7A 1ANJA 1AJBA 4KAVA 4ZG9A 1KH4A 4UPKA 4ZG6A 5INHA 4UPHA 2GSUA 5AJ9A 3WAVA 2VQRA 1O99A 3A52A 5HRTA 1E1ZP 1ELXA 3UN5A 3Q3QA 5LRNA 4CYSA 5EGHA 5LRMA 4LRCA 3MK0A 3B5QA 4GTXA 1ELYA 1ZEDA 5DLVA 3M8ZA 3M7VA
chains in the Genus database with same CATH superfamily
5LQQA 1HJKA 4LRDA 3SZYA 3NKNA 2W8DA 4FDJA 4LR7A 1ANIA 1HQAA 3BDGA 2ZKTA 3NKPA 5LIAA 1EI6A 1E3CP 3TX0A 1KHLA 4LRBA 2W5TA 4NWJA 1N2LA 4LQYA 1HDHA 4GTYA 3BDFA 1KH7A 2W8SA 2W5RA 1ALKA 1KHNA 4B56A 1KH5A 4QAXA 2W5WA 1KHKA 1Y7AA 4N7TA 1O98A 4YR1A 2W5QA 1B8JA 5TJ3A 4KJGA 4LRFA 2QZUA 5EGEA 2ANHA 4CXKA 3UO0A 1AJCA 1SHQA 1ED9A 2IUCA 2W5SA 4UPLA 3OT9A 3UN2A 1ED8A 5DLWA 3SZZA 4MY4A 1AJDA 1AUKA 3WAWA 1AJAA 1Y6VA 3WAYA 4ZGAA 1ALIA 1K7HA 4UORA 5IJQA 1KHJA 4CXUA 5DLTA 4GTWA 4FDIA 3MK2A 3IGZB 5C66A 1EQJA 1ZEBA 2XR9A 3NKRA 3NKQA 3UN3A 1URAA 2D1GA 4NWXA 1ZEFA 2GSNA 2RH6A 3E2DA 4KJDA 1EW8A 1KH9A 3TG0A 1N2KA 1URBA 3WBHA 4LR9A 5L0KA 1EW9A 5GOVA 4CYRA 3IDDA 2G9YA 5K4PA 3ED4A 1ALJA 4LR8A 3NKOA 5KXAA 1FSUA 1P49A 3LXQA 2W5XA 1E33P 1EW2A 1SHNA 3IGYB 3CMRA 2GSOA 3BDHA 5IJSA 3T02A 5L0EA 2IFYA 4MHXA 4MIVA 3UNYA 4LRAA 4LR2A 2W5VA 1ALHA 3DPCA 4UOPA 3KD8A 4TN0A 1E2SP 5GRRA 4CXSA 4LREA 4GTZA 4UOOA 3MK1A 3NKMA 3NVLA 3TWZA 1ELZA 2X98A 2XRGA 4KAYA 3M8WA 4KM4A 5L0BA 2IUCB 3WAXA 3T01A 4UPIA 2GA3A 3M8YA 3T00A 3DYCA 3BDGB 2GLQA 1EJJA 4ZG7A 1ANJA 1AJBA 4KAVA 4ZG9A 1KH4A 4UPKA 4ZG6A 5INHA 4UPHA 2GSUA 5AJ9A 3WAVA 2VQRA 1O99A 3A52A 5HRTA 1E1ZP 1ELXA 3UN5A 3Q3QA 5LRNA 4CYSA 5EGHA 5LRMA 4LRCA 3MK0A 3B5QA 4GTXA 1ELYA 1ZEDA 5DLVA 3M8ZA 3M7VA
chains in the Genus database with same CATH topology
5LQQA 1HJKA 4LRDA 3SZYA 3NKNA 2W8DA 4FDJA 4LR7A 1ANIA 1HQAA 3BDGA 2ZKTA 3NKPA 5LIAA 1EI6A 1E3CP 3TX0A 1KHLA 4LRBA 2W5TA 4NWJA 1N2LA 4LQYA 1HDHA 4GTYA 3BDFA 1KH7A 2W8SA 2W5RA 1ALKA 1KHNA 4B56A 1KH5A 4QAXA 2W5WA 1KHKA 1Y7AA 4N7TA 1O98A 4YR1A 2W5QA 1B8JA 5TJ3A 4KJGA 4LRFA 2QZUA 5EGEA 2ANHA 4CXKA 3UO0A 1AJCA 1SHQA 1ED9A 2IUCA 2W5SA 4UPLA 3OT9A 3UN2A 1ED8A 5DLWA 3SZZA 4MY4A 1AJDA 1AUKA 3WAWA 1AJAA 1Y6VA 3WAYA 4ZGAA 1ALIA 1K7HA 4UORA 5IJQA 1KHJA 4CXUA 5DLTA 4GTWA 4FDIA 3MK2A 3IGZB 5C66A 1EQJA 1ZEBA 2XR9A 3NKRA 3NKQA 3UN3A 1URAA 2D1GA 4NWXA 1ZEFA 2GSNA 2RH6A 3E2DA 4KJDA 1EW8A 1KH9A 3TG0A 1N2KA 1URBA 3WBHA 4LR9A 5L0KA 1EW9A 5GOVA 4CYRA 3IDDA 2G9YA 5K4PA 3ED4A 1ALJA 4LR8A 3NKOA 5KXAA 1FSUA 1P49A 3LXQA 2W5XA 1E33P 1EW2A 1SHNA 3IGYB 3CMRA 2GSOA 3BDHA 5IJSA 3T02A 5L0EA 2IFYA 4MHXA 4MIVA 3UNYA 4LRAA 4LR2A 2W5VA 1ALHA 3DPCA 4UOPA 3KD8A 4TN0A 1E2SP 5GRRA 4CXSA 4LREA 4GTZA 4UOOA 3MK1A 3NKMA 3NVLA 3TWZA 1ELZA 2X98A 2XRGA 4KAYA 3M8WA 4KM4A 5L0BA 2IUCB 3WAXA 3T01A 4UPIA 2GA3A 3M8YA 3T00A 3DYCA 3BDGB 2GLQA 1EJJA 4ZG7A 1ANJA 1AJBA 4KAVA 4ZG9A 1KH4A 4UPKA 4ZG6A 5INHA 4UPHA 2GSUA 5AJ9A 3WAVA 2VQRA 1O99A 3A52A 5HRTA 1E1ZP 1ELXA 3UN5A 3Q3QA 5LRNA 4CYSA 5EGHA 5LRMA 4LRCA 3MK0A 3B5QA 4GTXA 1ELYA 1ZEDA 5DLVA 3M8ZA 3M7VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LQQ A;  1HJK A;  4LRD A;  3SZY A;  3NKN A;  2W8D A;  4FDJ A;  4LR7 A;  1ANI A;  1HQA A;  3BDG A;  2ZKT A;  3NKP A;  5LIA A;  1EI6 A;  1E3C P;  3TX0 A;  1KHL A;  4LRB A;  2W5T A;  4NWJ A;  1N2L A;  4LQY A;  1HDH A;  4GTY A;  3BDF A;  1KH7 A;  2W8S A;  2W5R A;  1ALK A;  1KHN A;  4B56 A;  1KH5 A;  4QAX A;  2W5W A;  1KHK A;  1Y7A A;  4N7T A;  1O98 A;  4YR1 A;  2W5Q A;  1B8J A;  5TJ3 A;  4KJG A;  4LRF A;  2QZU A;  5EGE A;  2ANH A;  4CXK A;  3UO0 A;  1AJC A;  1SHQ A;  1ED9 A;  2IUC A;  2W5S A;  4UPL A;  3OT9 A;  3UN2 A;  1ED8 A;  5DLW A;  3SZZ A;  4MY4 A;  1AJD A;  1AUK A;  3WAW A;  1AJA A;  1Y6V A;  3WAY A;  4ZGA A;  1ALI A;  1K7H A;  4UOR A;  5IJQ A;  1KHJ A;  4CXU A;  5DLT A;  4GTW A;  4FDI A;  3MK2 A;  3IGZ B;  5C66 A;  1EQJ A;  1ZEB A;  2XR9 A;  3NKR A;  3NKQ A;  3UN3 A;  1URA A;  2D1G A;  4NWX A;  1ZEF A;  2GSN A;  2RH6 A;  3E2D A;  4KJD A;  1EW8 A;  1KH9 A;  3TG0 A;  1N2K A;  1URB A;  3WBH A;  4LR9 A;  5L0K A;  1EW9 A;  5GOV A;  4CYR A;  3IDD A;  2G9Y A;  5K4P A;  3ED4 A;  1ALJ A;  4LR8 A;  3NKO A;  5KXA A;  1FSU A;  1P49 A;  3LXQ A;  2W5X A;  1E33 P;  1EW2 A;  1SHN A;  3IGY B;  3CMR A;  2GSO A;  3BDH A;  5IJS A;  3T02 A;  5L0E A;  2IFY A;  4MHX A;  4MIV A;  3UNY A;  4LRA A;  4LR2 A;  2W5V A;  1ALH A;  3DPC A;  4UOP A;  3KD8 A;  4TN0 A;  1E2S P;  5GRR A;  4CXS A;  4LRE A;  4GTZ A;  4UOO A;  3MK1 A;  3NKM A;  3NVL A;  3TWZ A;  1ELZ A;  2X98 A;  2XRG A;  4KAY A;  3M8W A;  4KM4 A;  5L0B A;  2IUC B;  3WAX A;  3T01 A;  4UPI A;  2GA3 A;  3M8Y A;  3T00 A;  3DYC A;  3BDG B;  2GLQ A;  1EJJ A;  4ZG7 A;  1ANJ A;  1AJB A;  4KAV A;  4ZG9 A;  1KH4 A;  4UPK A;  4ZG6 A;  5INH A;  4UPH A;  2GSU A;  5AJ9 A;  3WAV A;  2VQR A;  1O99 A;  3A52 A;  5HRT A;  1E1Z P;  1ELX A;  3UN5 A;  3Q3Q A;  5LRN A;  4CYS A;  5EGH A;  5LRM A;  4LRC A;  3MK0 A;  3B5Q A;  4GTX A;  1ELY A;  1ZED A;  5DLV A;  3M8Z A;  3M7V A; 
#chains in the Genus database with same CATH topology
 5LQQ A;  1HJK A;  4LRD A;  3SZY A;  3NKN A;  2W8D A;  4FDJ A;  4LR7 A;  1ANI A;  1HQA A;  3BDG A;  2ZKT A;  3NKP A;  5LIA A;  1EI6 A;  1E3C P;  3TX0 A;  1KHL A;  4LRB A;  2W5T A;  4NWJ A;  1N2L A;  4LQY A;  1HDH A;  4GTY A;  3BDF A;  1KH7 A;  2W8S A;  2W5R A;  1ALK A;  1KHN A;  4B56 A;  1KH5 A;  4QAX A;  2W5W A;  1KHK A;  1Y7A A;  4N7T A;  1O98 A;  4YR1 A;  2W5Q A;  1B8J A;  5TJ3 A;  4KJG A;  4LRF A;  2QZU A;  5EGE A;  2ANH A;  4CXK A;  3UO0 A;  1AJC A;  1SHQ A;  1ED9 A;  2IUC A;  2W5S A;  4UPL A;  3OT9 A;  3UN2 A;  1ED8 A;  5DLW A;  3SZZ A;  4MY4 A;  1AJD A;  1AUK A;  3WAW A;  1AJA A;  1Y6V A;  3WAY A;  4ZGA A;  1ALI A;  1K7H A;  4UOR A;  5IJQ A;  1KHJ A;  4CXU A;  5DLT A;  4GTW A;  4FDI A;  3MK2 A;  3IGZ B;  5C66 A;  1EQJ A;  1ZEB A;  2XR9 A;  3NKR A;  3NKQ A;  3UN3 A;  1URA A;  2D1G A;  4NWX A;  1ZEF A;  2GSN A;  2RH6 A;  3E2D A;  4KJD A;  1EW8 A;  1KH9 A;  3TG0 A;  1N2K A;  1URB A;  3WBH A;  4LR9 A;  5L0K A;  1EW9 A;  5GOV A;  4CYR A;  3IDD A;  2G9Y A;  5K4P A;  3ED4 A;  1ALJ A;  4LR8 A;  3NKO A;  5KXA A;  1FSU A;  1P49 A;  3LXQ A;  2W5X A;  1E33 P;  1EW2 A;  1SHN A;  3IGY B;  3CMR A;  2GSO A;  3BDH A;  5IJS A;  3T02 A;  5L0E A;  2IFY A;  4MHX A;  4MIV A;  3UNY A;  4LRA A;  4LR2 A;  2W5V A;  1ALH A;  3DPC A;  4UOP A;  3KD8 A;  4TN0 A;  1E2S P;  5GRR A;  4CXS A;  4LRE A;  4GTZ A;  4UOO A;  3MK1 A;  3NKM A;  3NVL A;  3TWZ A;  1ELZ A;  2X98 A;  2XRG A;  4KAY A;  3M8W A;  4KM4 A;  5L0B A;  2IUC B;  3WAX A;  3T01 A;  4UPI A;  2GA3 A;  3M8Y A;  3T00 A;  3DYC A;  3BDG B;  2GLQ A;  1EJJ A;  4ZG7 A;  1ANJ A;  1AJB A;  4KAV A;  4ZG9 A;  1KH4 A;  4UPK A;  4ZG6 A;  5INH A;  4UPH A;  2GSU A;  5AJ9 A;  3WAV A;  2VQR A;  1O99 A;  3A52 A;  5HRT A;  1E1Z P;  1ELX A;  3UN5 A;  3Q3Q A;  5LRN A;  4CYS A;  5EGH A;  5LRM A;  4LRC A;  3MK0 A;  3B5Q A;  4GTX A;  1ELY A;  1ZED A;  5DLV A;  3M8Z A;  3M7V A; 
#chains in the Genus database with same CATH homology
 5LQQ A;  1HJK A;  4LRD A;  3SZY A;  3NKN A;  2W8D A;  4FDJ A;  4LR7 A;  1ANI A;  1HQA A;  3BDG A;  2ZKT A;  3NKP A;  5LIA A;  1EI6 A;  1E3C P;  3TX0 A;  1KHL A;  4LRB A;  2W5T A;  4NWJ A;  1N2L A;  4LQY A;  1HDH A;  4GTY A;  3BDF A;  1KH7 A;  2W8S A;  2W5R A;  1ALK A;  1KHN A;  4B56 A;  1KH5 A;  4QAX A;  2W5W A;  1KHK A;  1Y7A A;  4N7T A;  1O98 A;  4YR1 A;  2W5Q A;  1B8J A;  5TJ3 A;  4KJG A;  4LRF A;  2QZU A;  5EGE A;  2ANH A;  4CXK A;  3UO0 A;  1AJC A;  1SHQ A;  1ED9 A;  2IUC A;  2W5S A;  4UPL A;  3OT9 A;  3UN2 A;  1ED8 A;  5DLW A;  3SZZ A;  4MY4 A;  1AJD A;  1AUK A;  3WAW A;  1AJA A;  1Y6V A;  3WAY A;  4ZGA A;  1ALI A;  1K7H A;  4UOR A;  5IJQ A;  1KHJ A;  4CXU A;  5DLT A;  4GTW A;  4FDI A;  3MK2 A;  3IGZ B;  5C66 A;  1EQJ A;  1ZEB A;  2XR9 A;  3NKR A;  3NKQ A;  3UN3 A;  1URA A;  2D1G A;  4NWX A;  1ZEF A;  2GSN A;  2RH6 A;  3E2D A;  4KJD A;  1EW8 A;  1KH9 A;  3TG0 A;  1N2K A;  1URB A;  3WBH A;  4LR9 A;  5L0K A;  1EW9 A;  5GOV A;  4CYR A;  3IDD A;  2G9Y A;  5K4P A;  3ED4 A;  1ALJ A;  4LR8 A;  3NKO A;  5KXA A;  1FSU A;  1P49 A;  3LXQ A;  2W5X A;  1E33 P;  1EW2 A;  1SHN A;  3IGY B;  3CMR A;  2GSO A;  3BDH A;  5IJS A;  3T02 A;  5L0E A;  2IFY A;  4MHX A;  4MIV A;  3UNY A;  4LRA A;  4LR2 A;  2W5V A;  1ALH A;  3DPC A;  4UOP A;  3KD8 A;  4TN0 A;  1E2S P;  5GRR A;  4CXS A;  4LRE A;  4GTZ A;  4UOO A;  3MK1 A;  3NKM A;  3NVL A;  3TWZ A;  1ELZ A;  2X98 A;  2XRG A;  4KAY A;  3M8W A;  4KM4 A;  5L0B A;  2IUC B;  3WAX A;  3T01 A;  4UPI A;  2GA3 A;  3M8Y A;  3T00 A;  3DYC A;  3BDG B;  2GLQ A;  1EJJ A;  4ZG7 A;  1ANJ A;  1AJB A;  4KAV A;  4ZG9 A;  1KH4 A;  4UPK A;  4ZG6 A;  5INH A;  4UPH A;  2GSU A;  5AJ9 A;  3WAV A;  2VQR A;  1O99 A;  3A52 A;  5HRT A;  1E1Z P;  1ELX A;  3UN5 A;  3Q3Q A;  5LRN A;  4CYS A;  5EGH A;  5LRM A;  4LRC A;  3MK0 A;  3B5Q A;  4GTX A;  1ELY A;  1ZED A;  5DLV A;  3M8Z A;  3M7V A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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