2GA3A

Structure of s102t e. coli alkaline phosphatase-phosphate intermediate at 2.20a resolution
Total Genus 165
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
165
Knots found
sequence length
449
structure length
448
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title Trapping the tetrahedral intermediate in the alkaline phosphatase reaction by substitution of the active site serine with threonine.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 165
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2006-03-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2ga3A00
4LRBA 4LREA 1ALKA 1HDHA 1ELYA 2W5WA 3NKPA 3KD8A 1ED9A 1ELZA 4FDIA 4CXKA 3T02A 1KHJA 3IDDA 2W5TA 4B56A 3MK1A 4LR8A 5LRNA 2W5VA 4MHXA 4LRCA 2W8DA 3IGYB 3UN5A 1URAA 1ZEDA 2D1GA 3ED4A 4QAXA 5IJQA 3NKQA 4UPHA 4LR7A 4CYRA 3T00A 5IJSA 1ELXA 3NKNA 1AJBA 4LRDA 3OT9A 5GOVA 3TG0A 1SHNA 1ZEFA 3TWZA 2ANHA 4KJGA 5LRMA 1E33P 4ZGAA 3WAYA 4GTZA 4CYSA 3B5QA 4NWJA 2GSOA 1AJCA 5DLVA 2W5RA 2X98A 4YR1A 5C66A 1KH4A 2IFYA 1EW9A 3M7VA 4CXUA 4UORA 4LQYA 5GRRA 4GTXA 3UNYA 3T01A 4ZG6A 1ANIA 1E1ZP 4UPIA 1K7HA 4KM4A 1FSUA 1URBA 1AUKA 1EW2A 1E3CP 1KHNA 1Y7AA 3SZYA 1O98A 5LQQA 4LRFA 5K4PA 4LRAA 5L0KA 1ALJA 3MK0A 2G9YA 1ZEBA 1HJKA 2XRGA 2IUCA 4ZG7A 4N7TA 3WAWA 1KHKA 5L0EA 1ALHA 3M8YA 3IGZB 4LR2A 1N2KA 2W5SA 2W8SA 4UPLA 3BDHA 3UN2A 3SZZA 3BDFA 4UOOA 4FDJA 5LIAA 1EW8A 3Q3QA 1B8JA 2ZKTA 1SHQA 1ED8A 2GSNA 3UN3A 3BDGA 3CMRA 4TN0A 1Y6VA 4KJDA 1AJAA 3UO0A 3NKRA 2QZUA 2W5XA 5HRTA 1KHLA 1EI6A 2RH6A 4UOPA 3WBHA 3E2DA 1HQAA 3DPCA 1P49A 5DLTA 4ZG9A 1O99A 4GTYA 4MIVA 1N2LA 2GSUA 3NVLA 3NKMA 5TJ3A 3NKOA 1ALIA 5DLWA 2IUCB 2VQRA 4CXSA 3TX0A 4LR9A 1KH7A 1AJDA 4MY4A 1E2SP 1ANJA 4KAVA 5AJ9A 3A52A 1KH9A 1EJJA 5L0BA 2XR9A 4KAYA 4UPKA 5EGEA 2W5QA 3WAVA 3DYCA 3M8WA 1EQJA 1KH5A 4NWXA 5KXAA 3BDGB 4GTWA 3M8ZA 5EGHA 2GLQA 3MK2A 5INHA 3WAXA 2GA3A 3LXQA
chains in the Genus database with same CATH superfamily
4LRBA 4LREA 1ALKA 1HDHA 1ELYA 2W5WA 3NKPA 3KD8A 1ED9A 1ELZA 4FDIA 4CXKA 3T02A 1KHJA 3IDDA 2W5TA 4B56A 3MK1A 4LR8A 5LRNA 2W5VA 4MHXA 4LRCA 2W8DA 3IGYB 3UN5A 1URAA 1ZEDA 2D1GA 3ED4A 4QAXA 5IJQA 3NKQA 4UPHA 4LR7A 4CYRA 3T00A 5IJSA 1ELXA 3NKNA 1AJBA 4LRDA 3OT9A 5GOVA 3TG0A 1SHNA 1ZEFA 3TWZA 2ANHA 4KJGA 5LRMA 1E33P 4ZGAA 3WAYA 4GTZA 4CYSA 3B5QA 4NWJA 2GSOA 1AJCA 5DLVA 2W5RA 2X98A 4YR1A 5C66A 1KH4A 2IFYA 1EW9A 3M7VA 4CXUA 4UORA 4LQYA 5GRRA 4GTXA 3UNYA 3T01A 4ZG6A 1ANIA 1E1ZP 4UPIA 1K7HA 4KM4A 1FSUA 1URBA 1AUKA 1EW2A 1E3CP 1KHNA 1Y7AA 3SZYA 1O98A 5LQQA 4LRFA 5K4PA 4LRAA 5L0KA 1ALJA 3MK0A 2G9YA 1ZEBA 1HJKA 2XRGA 2IUCA 4ZG7A 4N7TA 3WAWA 1KHKA 5L0EA 1ALHA 3M8YA 3IGZB 4LR2A 1N2KA 2W5SA 2W8SA 4UPLA 3BDHA 3UN2A 3SZZA 3BDFA 4UOOA 4FDJA 5LIAA 1EW8A 3Q3QA 1B8JA 2ZKTA 1SHQA 1ED8A 2GSNA 3UN3A 3BDGA 3CMRA 4TN0A 1Y6VA 4KJDA 1AJAA 3UO0A 3NKRA 2QZUA 2W5XA 5HRTA 1KHLA 1EI6A 2RH6A 4UOPA 3WBHA 3E2DA 1HQAA 3DPCA 1P49A 5DLTA 4ZG9A 1O99A 4GTYA 4MIVA 1N2LA 2GSUA 3NVLA 3NKMA 5TJ3A 3NKOA 1ALIA 5DLWA 2IUCB 2VQRA 4CXSA 3TX0A 4LR9A 1KH7A 1AJDA 4MY4A 1E2SP 1ANJA 4KAVA 5AJ9A 3A52A 1KH9A 1EJJA 5L0BA 2XR9A 4KAYA 4UPKA 5EGEA 2W5QA 3WAVA 3DYCA 3M8WA 1EQJA 1KH5A 4NWXA 5KXAA 3BDGB 4GTWA 3M8ZA 5EGHA 2GLQA 3MK2A 5INHA 3WAXA 2GA3A 3LXQA
chains in the Genus database with same CATH topology
4LRBA 4LREA 1ALKA 1HDHA 1ELYA 2W5WA 3NKPA 3KD8A 1ED9A 1ELZA 4FDIA 4CXKA 3T02A 1KHJA 3IDDA 2W5TA 4B56A 3MK1A 4LR8A 5LRNA 2W5VA 4MHXA 4LRCA 2W8DA 3IGYB 3UN5A 1URAA 1ZEDA 2D1GA 3ED4A 4QAXA 5IJQA 3NKQA 4UPHA 4LR7A 4CYRA 3T00A 5IJSA 1ELXA 3NKNA 1AJBA 4LRDA 3OT9A 5GOVA 3TG0A 1SHNA 1ZEFA 3TWZA 2ANHA 4KJGA 5LRMA 1E33P 4ZGAA 3WAYA 4GTZA 4CYSA 3B5QA 4NWJA 2GSOA 1AJCA 5DLVA 2W5RA 2X98A 4YR1A 5C66A 1KH4A 2IFYA 1EW9A 3M7VA 4CXUA 4UORA 4LQYA 5GRRA 4GTXA 3UNYA 3T01A 4ZG6A 1ANIA 1E1ZP 4UPIA 1K7HA 4KM4A 1FSUA 1URBA 1AUKA 1EW2A 1E3CP 1KHNA 1Y7AA 3SZYA 1O98A 5LQQA 4LRFA 5K4PA 4LRAA 5L0KA 1ALJA 3MK0A 2G9YA 1ZEBA 1HJKA 2XRGA 2IUCA 4ZG7A 4N7TA 3WAWA 1KHKA 5L0EA 1ALHA 3M8YA 3IGZB 4LR2A 1N2KA 2W5SA 2W8SA 4UPLA 3BDHA 3UN2A 3SZZA 3BDFA 4UOOA 4FDJA 5LIAA 1EW8A 3Q3QA 1B8JA 2ZKTA 1SHQA 1ED8A 2GSNA 3UN3A 3BDGA 3CMRA 4TN0A 1Y6VA 4KJDA 1AJAA 3UO0A 3NKRA 2QZUA 2W5XA 5HRTA 1KHLA 1EI6A 2RH6A 4UOPA 3WBHA 3E2DA 1HQAA 3DPCA 1P49A 5DLTA 4ZG9A 1O99A 4GTYA 4MIVA 1N2LA 2GSUA 3NVLA 3NKMA 5TJ3A 3NKOA 1ALIA 5DLWA 2IUCB 2VQRA 4CXSA 3TX0A 4LR9A 1KH7A 1AJDA 4MY4A 1E2SP 1ANJA 4KAVA 5AJ9A 3A52A 1KH9A 1EJJA 5L0BA 2XR9A 4KAYA 4UPKA 5EGEA 2W5QA 3WAVA 3DYCA 3M8WA 1EQJA 1KH5A 4NWXA 5KXAA 3BDGB 4GTWA 3M8ZA 5EGHA 2GLQA 3MK2A 5INHA 3WAXA 2GA3A 3LXQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LRB A;  4LRE A;  1ALK A;  1HDH A;  1ELY A;  2W5W A;  3NKP A;  3KD8 A;  1ED9 A;  1ELZ A;  4FDI A;  4CXK A;  3T02 A;  1KHJ A;  3IDD A;  2W5T A;  4B56 A;  3MK1 A;  4LR8 A;  5LRN A;  2W5V A;  4MHX A;  4LRC A;  2W8D A;  3IGY B;  3UN5 A;  1URA A;  1ZED A;  2D1G A;  3ED4 A;  4QAX A;  5IJQ A;  3NKQ A;  4UPH A;  4LR7 A;  4CYR A;  3T00 A;  5IJS A;  1ELX A;  3NKN A;  1AJB A;  4LRD A;  3OT9 A;  5GOV A;  3TG0 A;  1SHN A;  1ZEF A;  3TWZ A;  2ANH A;  4KJG A;  5LRM A;  1E33 P;  4ZGA A;  3WAY A;  4GTZ A;  4CYS A;  3B5Q A;  4NWJ A;  2GSO A;  1AJC A;  5DLV A;  2W5R A;  2X98 A;  4YR1 A;  5C66 A;  1KH4 A;  2IFY A;  1EW9 A;  3M7V A;  4CXU A;  4UOR A;  4LQY A;  5GRR A;  4GTX A;  3UNY A;  3T01 A;  4ZG6 A;  1ANI A;  1E1Z P;  4UPI A;  1K7H A;  4KM4 A;  1FSU A;  1URB A;  1AUK A;  1EW2 A;  1E3C P;  1KHN A;  1Y7A A;  3SZY A;  1O98 A;  5LQQ A;  4LRF A;  5K4P A;  4LRA A;  5L0K A;  1ALJ A;  3MK0 A;  2G9Y A;  1ZEB A;  1HJK A;  2XRG A;  2IUC A;  4ZG7 A;  4N7T A;  3WAW A;  1KHK A;  5L0E A;  1ALH A;  3M8Y A;  3IGZ B;  4LR2 A;  1N2K A;  2W5S A;  2W8S A;  4UPL A;  3BDH A;  3UN2 A;  3SZZ A;  3BDF A;  4UOO A;  4FDJ A;  5LIA A;  1EW8 A;  3Q3Q A;  1B8J A;  2ZKT A;  1SHQ A;  1ED8 A;  2GSN A;  3UN3 A;  3BDG A;  3CMR A;  4TN0 A;  1Y6V A;  4KJD A;  1AJA A;  3UO0 A;  3NKR A;  2QZU A;  2W5X A;  5HRT A;  1KHL A;  1EI6 A;  2RH6 A;  4UOP A;  3WBH A;  3E2D A;  1HQA A;  3DPC A;  1P49 A;  5DLT A;  4ZG9 A;  1O99 A;  4GTY A;  4MIV A;  1N2L A;  2GSU A;  3NVL A;  3NKM A;  5TJ3 A;  3NKO A;  1ALI A;  5DLW A;  2IUC B;  2VQR A;  4CXS A;  3TX0 A;  4LR9 A;  1KH7 A;  1AJD A;  4MY4 A;  1E2S P;  1ANJ A;  4KAV A;  5AJ9 A;  3A52 A;  1KH9 A;  1EJJ A;  5L0B A;  2XR9 A;  4KAY A;  4UPK A;  5EGE A;  2W5Q A;  3WAV A;  3DYC A;  3M8W A;  1EQJ A;  1KH5 A;  4NWX A;  5KXA A;  3BDG B;  4GTW A;  3M8Z A;  5EGH A;  2GLQ A;  3MK2 A;  5INH A;  3WAX A;  2GA3 A;  3LXQ A; 
#chains in the Genus database with same CATH topology
 4LRB A;  4LRE A;  1ALK A;  1HDH A;  1ELY A;  2W5W A;  3NKP A;  3KD8 A;  1ED9 A;  1ELZ A;  4FDI A;  4CXK A;  3T02 A;  1KHJ A;  3IDD A;  2W5T A;  4B56 A;  3MK1 A;  4LR8 A;  5LRN A;  2W5V A;  4MHX A;  4LRC A;  2W8D A;  3IGY B;  3UN5 A;  1URA A;  1ZED A;  2D1G A;  3ED4 A;  4QAX A;  5IJQ A;  3NKQ A;  4UPH A;  4LR7 A;  4CYR A;  3T00 A;  5IJS A;  1ELX A;  3NKN A;  1AJB A;  4LRD A;  3OT9 A;  5GOV A;  3TG0 A;  1SHN A;  1ZEF A;  3TWZ A;  2ANH A;  4KJG A;  5LRM A;  1E33 P;  4ZGA A;  3WAY A;  4GTZ A;  4CYS A;  3B5Q A;  4NWJ A;  2GSO A;  1AJC A;  5DLV A;  2W5R A;  2X98 A;  4YR1 A;  5C66 A;  1KH4 A;  2IFY A;  1EW9 A;  3M7V A;  4CXU A;  4UOR A;  4LQY A;  5GRR A;  4GTX A;  3UNY A;  3T01 A;  4ZG6 A;  1ANI A;  1E1Z P;  4UPI A;  1K7H A;  4KM4 A;  1FSU A;  1URB A;  1AUK A;  1EW2 A;  1E3C P;  1KHN A;  1Y7A A;  3SZY A;  1O98 A;  5LQQ A;  4LRF A;  5K4P A;  4LRA A;  5L0K A;  1ALJ A;  3MK0 A;  2G9Y A;  1ZEB A;  1HJK A;  2XRG A;  2IUC A;  4ZG7 A;  4N7T A;  3WAW A;  1KHK A;  5L0E A;  1ALH A;  3M8Y A;  3IGZ B;  4LR2 A;  1N2K A;  2W5S A;  2W8S A;  4UPL A;  3BDH A;  3UN2 A;  3SZZ A;  3BDF A;  4UOO A;  4FDJ A;  5LIA A;  1EW8 A;  3Q3Q A;  1B8J A;  2ZKT A;  1SHQ A;  1ED8 A;  2GSN A;  3UN3 A;  3BDG A;  3CMR A;  4TN0 A;  1Y6V A;  4KJD A;  1AJA A;  3UO0 A;  3NKR A;  2QZU A;  2W5X A;  5HRT A;  1KHL A;  1EI6 A;  2RH6 A;  4UOP A;  3WBH A;  3E2D A;  1HQA A;  3DPC A;  1P49 A;  5DLT A;  4ZG9 A;  1O99 A;  4GTY A;  4MIV A;  1N2L A;  2GSU A;  3NVL A;  3NKM A;  5TJ3 A;  3NKO A;  1ALI A;  5DLW A;  2IUC B;  2VQR A;  4CXS A;  3TX0 A;  4LR9 A;  1KH7 A;  1AJD A;  4MY4 A;  1E2S P;  1ANJ A;  4KAV A;  5AJ9 A;  3A52 A;  1KH9 A;  1EJJ A;  5L0B A;  2XR9 A;  4KAY A;  4UPK A;  5EGE A;  2W5Q A;  3WAV A;  3DYC A;  3M8W A;  1EQJ A;  1KH5 A;  4NWX A;  5KXA A;  3BDG B;  4GTW A;  3M8Z A;  5EGH A;  2GLQ A;  3MK2 A;  5INH A;  3WAX A;  2GA3 A;  3LXQ A; 
#chains in the Genus database with same CATH homology
 4LRB A;  4LRE A;  1ALK A;  1HDH A;  1ELY A;  2W5W A;  3NKP A;  3KD8 A;  1ED9 A;  1ELZ A;  4FDI A;  4CXK A;  3T02 A;  1KHJ A;  3IDD A;  2W5T A;  4B56 A;  3MK1 A;  4LR8 A;  5LRN A;  2W5V A;  4MHX A;  4LRC A;  2W8D A;  3IGY B;  3UN5 A;  1URA A;  1ZED A;  2D1G A;  3ED4 A;  4QAX A;  5IJQ A;  3NKQ A;  4UPH A;  4LR7 A;  4CYR A;  3T00 A;  5IJS A;  1ELX A;  3NKN A;  1AJB A;  4LRD A;  3OT9 A;  5GOV A;  3TG0 A;  1SHN A;  1ZEF A;  3TWZ A;  2ANH A;  4KJG A;  5LRM A;  1E33 P;  4ZGA A;  3WAY A;  4GTZ A;  4CYS A;  3B5Q A;  4NWJ A;  2GSO A;  1AJC A;  5DLV A;  2W5R A;  2X98 A;  4YR1 A;  5C66 A;  1KH4 A;  2IFY A;  1EW9 A;  3M7V A;  4CXU A;  4UOR A;  4LQY A;  5GRR A;  4GTX A;  3UNY A;  3T01 A;  4ZG6 A;  1ANI A;  1E1Z P;  4UPI A;  1K7H A;  4KM4 A;  1FSU A;  1URB A;  1AUK A;  1EW2 A;  1E3C P;  1KHN A;  1Y7A A;  3SZY A;  1O98 A;  5LQQ A;  4LRF A;  5K4P A;  4LRA A;  5L0K A;  1ALJ A;  3MK0 A;  2G9Y A;  1ZEB A;  1HJK A;  2XRG A;  2IUC A;  4ZG7 A;  4N7T A;  3WAW A;  1KHK A;  5L0E A;  1ALH A;  3M8Y A;  3IGZ B;  4LR2 A;  1N2K A;  2W5S A;  2W8S A;  4UPL A;  3BDH A;  3UN2 A;  3SZZ A;  3BDF A;  4UOO A;  4FDJ A;  5LIA A;  1EW8 A;  3Q3Q A;  1B8J A;  2ZKT A;  1SHQ A;  1ED8 A;  2GSN A;  3UN3 A;  3BDG A;  3CMR A;  4TN0 A;  1Y6V A;  4KJD A;  1AJA A;  3UO0 A;  3NKR A;  2QZU A;  2W5X A;  5HRT A;  1KHL A;  1EI6 A;  2RH6 A;  4UOP A;  3WBH A;  3E2D A;  1HQA A;  3DPC A;  1P49 A;  5DLT A;  4ZG9 A;  1O99 A;  4GTY A;  4MIV A;  1N2L A;  2GSU A;  3NVL A;  3NKM A;  5TJ3 A;  3NKO A;  1ALI A;  5DLW A;  2IUC B;  2VQR A;  4CXS A;  3TX0 A;  4LR9 A;  1KH7 A;  1AJD A;  4MY4 A;  1E2S P;  1ANJ A;  4KAV A;  5AJ9 A;  3A52 A;  1KH9 A;  1EJJ A;  5L0B A;  2XR9 A;  4KAY A;  4UPK A;  5EGE A;  2W5Q A;  3WAV A;  3DYC A;  3M8W A;  1EQJ A;  1KH5 A;  4NWX A;  5KXA A;  3BDG B;  4GTW A;  3M8Z A;  5EGH A;  2GLQ A;  3MK2 A;  5INH A;  3WAX A;  2GA3 A;  3LXQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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