2GA3A

Structure of s102t e. coli alkaline phosphatase-phosphate intermediate at 2.20a resolution
Total Genus 165
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
165
Knots found
sequence length
449
structure length
448
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Trapping the tetrahedral intermediate in the alkaline phosphatase reaction by substitution of the active site serine with threonine.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 165
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2006-03-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2ga3A00
2GA3A 1AJDA 2G9YA 3SZZA 2W8DA 1AJBA 1ALKA 3NKMA 3DPCA 3MK2A 5TJ3A 3BDGA 1ED9A 3M8YA 4CYRA 4UOOA 4MHXA 2IFYA 1E1ZP 1E33P 1ZEDA 1KH4A 3MK0A 3BDHA 3IDDA 5DLTA 5KXAA 4CXSA 1KH9A 5L0BA 1O98A 3UN2A 3OT9A 4LRBA 1KHNA 1KH7A 1EW2A 2GSOA 2W5SA 4LR7A 5L0KA 1URAA 4N7TA 2QZUA 5LRMA 1FSUA 2X98A 3NKOA 4LREA 3WAYA 3T01A 1P49A 2IUCB 5INHA 4LR2A 4KJDA 5GRRA 4GTYA 3UN5A 1HDHA 2GSUA 4TN0A 3TX0A 4YR1A 4UPIA 4ZGAA 2W5WA 2W5RA 1SHNA 4KM4A 5L0EA 3SZYA 3TG0A 3LXQA 1ELXA 1AJCA 4KAVA 3MK1A 3T02A 2ANHA 3TWZA 3UN3A 4UPHA 3BDFA 2W5VA 3M7VA 2IUCA 5GOVA 3M8WA 3NKQA 5EGHA 1HJKA 4UPLA 1AJAA 5K4PA 5DLWA 1Y6VA 4GTXA 4LRAA 2ZKTA 1EI6A 3WAWA 3UO0A 1B8JA 5LRNA 1O99A 4ZG6A 4FDJA 3WBHA 3DYCA 3IGZB 3IGYB 4ZG7A 1ALJA 1ED8A 1HQAA 3CMRA 2W5QA 2W5XA 4ZG9A 3ED4A 1ALHA 4LRCA 3Q3QA 4LR9A 1EW9A 3M8ZA 3WAXA 1ANIA 3KD8A 1EJJA 4GTZA 1KHLA 4UORA 5IJQA 2RH6A 1ANJA 1K7HA 3B5QA 4LRFA 4MIVA 1N2LA 1Y7AA 3NKNA 4MY4A 3UNYA 2W8SA 3NVLA 4KAYA 4CYSA 3NKRA 5DLVA 4NWJA 2D1GA 5LQQA 1KHJA 1SHQA 5HRTA 3A52A 2GLQA 4QAXA 3WAVA 2XR9A 4KJGA 1ELZA 1AUKA 1ZEBA 1N2KA 1URBA 4LR8A 3BDGB 4UPKA 5AJ9A 4B56A 4UOPA 4CXKA 1KH5A 4LQYA 1ELYA 1E2SP 5C66A 2W5TA 1EW8A 4NWXA 5EGEA 4CXUA 5IJSA 2GSNA 3E2DA 5LIAA 3NKPA 4LRDA 3T00A 2VQRA 1EQJA 1KHKA 1ALIA 4GTWA 1ZEFA 2XRGA 1E3CP 4FDIA
chains in the Genus database with same CATH superfamily
2GA3A 1AJDA 2G9YA 3SZZA 2W8DA 1AJBA 1ALKA 3NKMA 3DPCA 3MK2A 5TJ3A 3BDGA 1ED9A 3M8YA 4CYRA 4UOOA 4MHXA 2IFYA 1E1ZP 1E33P 1ZEDA 1KH4A 3MK0A 3BDHA 3IDDA 5DLTA 5KXAA 4CXSA 1KH9A 5L0BA 1O98A 3UN2A 3OT9A 4LRBA 1KHNA 1KH7A 1EW2A 2GSOA 2W5SA 4LR7A 5L0KA 1URAA 4N7TA 2QZUA 5LRMA 1FSUA 2X98A 3NKOA 4LREA 3WAYA 3T01A 1P49A 2IUCB 5INHA 4LR2A 4KJDA 5GRRA 4GTYA 3UN5A 1HDHA 2GSUA 4TN0A 3TX0A 4YR1A 4UPIA 4ZGAA 2W5WA 2W5RA 1SHNA 4KM4A 5L0EA 3SZYA 3TG0A 3LXQA 1ELXA 1AJCA 4KAVA 3MK1A 3T02A 2ANHA 3TWZA 3UN3A 4UPHA 3BDFA 2W5VA 3M7VA 2IUCA 5GOVA 3M8WA 3NKQA 5EGHA 1HJKA 4UPLA 1AJAA 5K4PA 5DLWA 1Y6VA 4GTXA 4LRAA 2ZKTA 1EI6A 3WAWA 3UO0A 1B8JA 5LRNA 1O99A 4ZG6A 4FDJA 3WBHA 3DYCA 3IGZB 3IGYB 4ZG7A 1ALJA 1ED8A 1HQAA 3CMRA 2W5QA 2W5XA 4ZG9A 3ED4A 1ALHA 4LRCA 3Q3QA 4LR9A 1EW9A 3M8ZA 3WAXA 1ANIA 3KD8A 1EJJA 4GTZA 1KHLA 4UORA 5IJQA 2RH6A 1ANJA 1K7HA 3B5QA 4LRFA 4MIVA 1N2LA 1Y7AA 3NKNA 4MY4A 3UNYA 2W8SA 3NVLA 4KAYA 4CYSA 3NKRA 5DLVA 4NWJA 2D1GA 5LQQA 1KHJA 1SHQA 5HRTA 3A52A 2GLQA 4QAXA 3WAVA 2XR9A 4KJGA 1ELZA 1AUKA 1ZEBA 1N2KA 1URBA 4LR8A 3BDGB 4UPKA 5AJ9A 4B56A 4UOPA 4CXKA 1KH5A 4LQYA 1ELYA 1E2SP 5C66A 2W5TA 1EW8A 4NWXA 5EGEA 4CXUA 5IJSA 2GSNA 3E2DA 5LIAA 3NKPA 4LRDA 3T00A 2VQRA 1EQJA 1KHKA 1ALIA 4GTWA 1ZEFA 2XRGA 1E3CP 4FDIA
chains in the Genus database with same CATH topology
2GA3A 1AJDA 2G9YA 3SZZA 2W8DA 1AJBA 1ALKA 3NKMA 3DPCA 3MK2A 5TJ3A 3BDGA 1ED9A 3M8YA 4CYRA 4UOOA 4MHXA 2IFYA 1E1ZP 1E33P 1ZEDA 1KH4A 3MK0A 3BDHA 3IDDA 5DLTA 5KXAA 4CXSA 1KH9A 5L0BA 1O98A 3UN2A 3OT9A 4LRBA 1KHNA 1KH7A 1EW2A 2GSOA 2W5SA 4LR7A 5L0KA 1URAA 4N7TA 2QZUA 5LRMA 1FSUA 2X98A 3NKOA 4LREA 3WAYA 3T01A 1P49A 2IUCB 5INHA 4LR2A 4KJDA 5GRRA 4GTYA 3UN5A 1HDHA 2GSUA 4TN0A 3TX0A 4YR1A 4UPIA 4ZGAA 2W5WA 2W5RA 1SHNA 4KM4A 5L0EA 3SZYA 3TG0A 3LXQA 1ELXA 1AJCA 4KAVA 3MK1A 3T02A 2ANHA 3TWZA 3UN3A 4UPHA 3BDFA 2W5VA 3M7VA 2IUCA 5GOVA 3M8WA 3NKQA 5EGHA 1HJKA 4UPLA 1AJAA 5K4PA 5DLWA 1Y6VA 4GTXA 4LRAA 2ZKTA 1EI6A 3WAWA 3UO0A 1B8JA 5LRNA 1O99A 4ZG6A 4FDJA 3WBHA 3DYCA 3IGZB 3IGYB 4ZG7A 1ALJA 1ED8A 1HQAA 3CMRA 2W5QA 2W5XA 4ZG9A 3ED4A 1ALHA 4LRCA 3Q3QA 4LR9A 1EW9A 3M8ZA 3WAXA 1ANIA 3KD8A 1EJJA 4GTZA 1KHLA 4UORA 5IJQA 2RH6A 1ANJA 1K7HA 3B5QA 4LRFA 4MIVA 1N2LA 1Y7AA 3NKNA 4MY4A 3UNYA 2W8SA 3NVLA 4KAYA 4CYSA 3NKRA 5DLVA 4NWJA 2D1GA 5LQQA 1KHJA 1SHQA 5HRTA 3A52A 2GLQA 4QAXA 3WAVA 2XR9A 4KJGA 1ELZA 1AUKA 1ZEBA 1N2KA 1URBA 4LR8A 3BDGB 4UPKA 5AJ9A 4B56A 4UOPA 4CXKA 1KH5A 4LQYA 1ELYA 1E2SP 5C66A 2W5TA 1EW8A 4NWXA 5EGEA 4CXUA 5IJSA 2GSNA 3E2DA 5LIAA 3NKPA 4LRDA 3T00A 2VQRA 1EQJA 1KHKA 1ALIA 4GTWA 1ZEFA 2XRGA 1E3CP 4FDIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GA3 A;  1AJD A;  2G9Y A;  3SZZ A;  2W8D A;  1AJB A;  1ALK A;  3NKM A;  3DPC A;  3MK2 A;  5TJ3 A;  3BDG A;  1ED9 A;  3M8Y A;  4CYR A;  4UOO A;  4MHX A;  2IFY A;  1E1Z P;  1E33 P;  1ZED A;  1KH4 A;  3MK0 A;  3BDH A;  3IDD A;  5DLT A;  5KXA A;  4CXS A;  1KH9 A;  5L0B A;  1O98 A;  3UN2 A;  3OT9 A;  4LRB A;  1KHN A;  1KH7 A;  1EW2 A;  2GSO A;  2W5S A;  4LR7 A;  5L0K A;  1URA A;  4N7T A;  2QZU A;  5LRM A;  1FSU A;  2X98 A;  3NKO A;  4LRE A;  3WAY A;  3T01 A;  1P49 A;  2IUC B;  5INH A;  4LR2 A;  4KJD A;  5GRR A;  4GTY A;  3UN5 A;  1HDH A;  2GSU A;  4TN0 A;  3TX0 A;  4YR1 A;  4UPI A;  4ZGA A;  2W5W A;  2W5R A;  1SHN A;  4KM4 A;  5L0E A;  3SZY A;  3TG0 A;  3LXQ A;  1ELX A;  1AJC A;  4KAV A;  3MK1 A;  3T02 A;  2ANH A;  3TWZ A;  3UN3 A;  4UPH A;  3BDF A;  2W5V A;  3M7V A;  2IUC A;  5GOV A;  3M8W A;  3NKQ A;  5EGH A;  1HJK A;  4UPL A;  1AJA A;  5K4P A;  5DLW A;  1Y6V A;  4GTX A;  4LRA A;  2ZKT A;  1EI6 A;  3WAW A;  3UO0 A;  1B8J A;  5LRN A;  1O99 A;  4ZG6 A;  4FDJ A;  3WBH A;  3DYC A;  3IGZ B;  3IGY B;  4ZG7 A;  1ALJ A;  1ED8 A;  1HQA A;  3CMR A;  2W5Q A;  2W5X A;  4ZG9 A;  3ED4 A;  1ALH A;  4LRC A;  3Q3Q A;  4LR9 A;  1EW9 A;  3M8Z A;  3WAX A;  1ANI A;  3KD8 A;  1EJJ A;  4GTZ A;  1KHL A;  4UOR A;  5IJQ A;  2RH6 A;  1ANJ A;  1K7H A;  3B5Q A;  4LRF A;  4MIV A;  1N2L A;  1Y7A A;  3NKN A;  4MY4 A;  3UNY A;  2W8S A;  3NVL A;  4KAY A;  4CYS A;  3NKR A;  5DLV A;  4NWJ A;  2D1G A;  5LQQ A;  1KHJ A;  1SHQ A;  5HRT A;  3A52 A;  2GLQ A;  4QAX A;  3WAV A;  2XR9 A;  4KJG A;  1ELZ A;  1AUK A;  1ZEB A;  1N2K A;  1URB A;  4LR8 A;  3BDG B;  4UPK A;  5AJ9 A;  4B56 A;  4UOP A;  4CXK A;  1KH5 A;  4LQY A;  1ELY A;  1E2S P;  5C66 A;  2W5T A;  1EW8 A;  4NWX A;  5EGE A;  4CXU A;  5IJS A;  2GSN A;  3E2D A;  5LIA A;  3NKP A;  4LRD A;  3T00 A;  2VQR A;  1EQJ A;  1KHK A;  1ALI A;  4GTW A;  1ZEF A;  2XRG A;  1E3C P;  4FDI A; 
#chains in the Genus database with same CATH topology
 2GA3 A;  1AJD A;  2G9Y A;  3SZZ A;  2W8D A;  1AJB A;  1ALK A;  3NKM A;  3DPC A;  3MK2 A;  5TJ3 A;  3BDG A;  1ED9 A;  3M8Y A;  4CYR A;  4UOO A;  4MHX A;  2IFY A;  1E1Z P;  1E33 P;  1ZED A;  1KH4 A;  3MK0 A;  3BDH A;  3IDD A;  5DLT A;  5KXA A;  4CXS A;  1KH9 A;  5L0B A;  1O98 A;  3UN2 A;  3OT9 A;  4LRB A;  1KHN A;  1KH7 A;  1EW2 A;  2GSO A;  2W5S A;  4LR7 A;  5L0K A;  1URA A;  4N7T A;  2QZU A;  5LRM A;  1FSU A;  2X98 A;  3NKO A;  4LRE A;  3WAY A;  3T01 A;  1P49 A;  2IUC B;  5INH A;  4LR2 A;  4KJD A;  5GRR A;  4GTY A;  3UN5 A;  1HDH A;  2GSU A;  4TN0 A;  3TX0 A;  4YR1 A;  4UPI A;  4ZGA A;  2W5W A;  2W5R A;  1SHN A;  4KM4 A;  5L0E A;  3SZY A;  3TG0 A;  3LXQ A;  1ELX A;  1AJC A;  4KAV A;  3MK1 A;  3T02 A;  2ANH A;  3TWZ A;  3UN3 A;  4UPH A;  3BDF A;  2W5V A;  3M7V A;  2IUC A;  5GOV A;  3M8W A;  3NKQ A;  5EGH A;  1HJK A;  4UPL A;  1AJA A;  5K4P A;  5DLW A;  1Y6V A;  4GTX A;  4LRA A;  2ZKT A;  1EI6 A;  3WAW A;  3UO0 A;  1B8J A;  5LRN A;  1O99 A;  4ZG6 A;  4FDJ A;  3WBH A;  3DYC A;  3IGZ B;  3IGY B;  4ZG7 A;  1ALJ A;  1ED8 A;  1HQA A;  3CMR A;  2W5Q A;  2W5X A;  4ZG9 A;  3ED4 A;  1ALH A;  4LRC A;  3Q3Q A;  4LR9 A;  1EW9 A;  3M8Z A;  3WAX A;  1ANI A;  3KD8 A;  1EJJ A;  4GTZ A;  1KHL A;  4UOR A;  5IJQ A;  2RH6 A;  1ANJ A;  1K7H A;  3B5Q A;  4LRF A;  4MIV A;  1N2L A;  1Y7A A;  3NKN A;  4MY4 A;  3UNY A;  2W8S A;  3NVL A;  4KAY A;  4CYS A;  3NKR A;  5DLV A;  4NWJ A;  2D1G A;  5LQQ A;  1KHJ A;  1SHQ A;  5HRT A;  3A52 A;  2GLQ A;  4QAX A;  3WAV A;  2XR9 A;  4KJG A;  1ELZ A;  1AUK A;  1ZEB A;  1N2K A;  1URB A;  4LR8 A;  3BDG B;  4UPK A;  5AJ9 A;  4B56 A;  4UOP A;  4CXK A;  1KH5 A;  4LQY A;  1ELY A;  1E2S P;  5C66 A;  2W5T A;  1EW8 A;  4NWX A;  5EGE A;  4CXU A;  5IJS A;  2GSN A;  3E2D A;  5LIA A;  3NKP A;  4LRD A;  3T00 A;  2VQR A;  1EQJ A;  1KHK A;  1ALI A;  4GTW A;  1ZEF A;  2XRG A;  1E3C P;  4FDI A; 
#chains in the Genus database with same CATH homology
 2GA3 A;  1AJD A;  2G9Y A;  3SZZ A;  2W8D A;  1AJB A;  1ALK A;  3NKM A;  3DPC A;  3MK2 A;  5TJ3 A;  3BDG A;  1ED9 A;  3M8Y A;  4CYR A;  4UOO A;  4MHX A;  2IFY A;  1E1Z P;  1E33 P;  1ZED A;  1KH4 A;  3MK0 A;  3BDH A;  3IDD A;  5DLT A;  5KXA A;  4CXS A;  1KH9 A;  5L0B A;  1O98 A;  3UN2 A;  3OT9 A;  4LRB A;  1KHN A;  1KH7 A;  1EW2 A;  2GSO A;  2W5S A;  4LR7 A;  5L0K A;  1URA A;  4N7T A;  2QZU A;  5LRM A;  1FSU A;  2X98 A;  3NKO A;  4LRE A;  3WAY A;  3T01 A;  1P49 A;  2IUC B;  5INH A;  4LR2 A;  4KJD A;  5GRR A;  4GTY A;  3UN5 A;  1HDH A;  2GSU A;  4TN0 A;  3TX0 A;  4YR1 A;  4UPI A;  4ZGA A;  2W5W A;  2W5R A;  1SHN A;  4KM4 A;  5L0E A;  3SZY A;  3TG0 A;  3LXQ A;  1ELX A;  1AJC A;  4KAV A;  3MK1 A;  3T02 A;  2ANH A;  3TWZ A;  3UN3 A;  4UPH A;  3BDF A;  2W5V A;  3M7V A;  2IUC A;  5GOV A;  3M8W A;  3NKQ A;  5EGH A;  1HJK A;  4UPL A;  1AJA A;  5K4P A;  5DLW A;  1Y6V A;  4GTX A;  4LRA A;  2ZKT A;  1EI6 A;  3WAW A;  3UO0 A;  1B8J A;  5LRN A;  1O99 A;  4ZG6 A;  4FDJ A;  3WBH A;  3DYC A;  3IGZ B;  3IGY B;  4ZG7 A;  1ALJ A;  1ED8 A;  1HQA A;  3CMR A;  2W5Q A;  2W5X A;  4ZG9 A;  3ED4 A;  1ALH A;  4LRC A;  3Q3Q A;  4LR9 A;  1EW9 A;  3M8Z A;  3WAX A;  1ANI A;  3KD8 A;  1EJJ A;  4GTZ A;  1KHL A;  4UOR A;  5IJQ A;  2RH6 A;  1ANJ A;  1K7H A;  3B5Q A;  4LRF A;  4MIV A;  1N2L A;  1Y7A A;  3NKN A;  4MY4 A;  3UNY A;  2W8S A;  3NVL A;  4KAY A;  4CYS A;  3NKR A;  5DLV A;  4NWJ A;  2D1G A;  5LQQ A;  1KHJ A;  1SHQ A;  5HRT A;  3A52 A;  2GLQ A;  4QAX A;  3WAV A;  2XR9 A;  4KJG A;  1ELZ A;  1AUK A;  1ZEB A;  1N2K A;  1URB A;  4LR8 A;  3BDG B;  4UPK A;  5AJ9 A;  4B56 A;  4UOP A;  4CXK A;  1KH5 A;  4LQY A;  1ELY A;  1E2S P;  5C66 A;  2W5T A;  1EW8 A;  4NWX A;  5EGE A;  4CXU A;  5IJS A;  2GSN A;  3E2D A;  5LIA A;  3NKP A;  4LRD A;  3T00 A;  2VQR A;  1EQJ A;  1KHK A;  1ALI A;  4GTW A;  1ZEF A;  2XRG A;  1E3C P;  4FDI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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