2GG7A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 85
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 85
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg7A00
2OKNA 5JI6A 2BHBA 4U69A 2MATA 2NQ6A 1YW7A 2V3XA 1BN5A 1WN1A 2BWTA 5CNXA 2ZSGA 4R60A 2GZ5A 5CE6A 2B3HA 1Y1NA 1WBQA 2EVCA 3RVAA 2B3KA 4ZWUA 3MX6A 1XGNA 4U6EA 4A6VA 2BN7A 4U6WA 2NQ7A 4FLKA 4MATA 2GGBA 4U6ZA 2GG3A 4IU6A 5FCHA 4RGZ1 4HXXA 2Q93A 2P9AA 5JHUA 4PNCA 2IW2A 3PKCA 1YW9A 2EVOA 5E5BA 3PKEA 2BWSA 2B3LA 2V6CA 4IDYA 3IG4A 5CLSA 4IKTA 3S6BA 4U6CA 5JFRA 2DFIA 1WY2A 2BWVA 3D27A 4Z7MA 2BHDA 2GU6A 1KP0A 1XGMA 2GG0A 3FMRA 4PV4A 1QZYA 4A6WA 4U6JA 3IU7A 2GG9A 1QXWA 2Q95A 4RZZA 2Q8KA 5CDLA 2BB7A 1WLRA 1PV9A 3IU8A 2P99A 1KQ0A 2BHAA 1BOAA 4S2RP 4ZWOA 1W7VA 2BHCA 1YW8A 4FLJA 2OAZA 4JUQA 1A16A 1YVMA 2BWUA 1R5GA 2GU5A 3BITA 3FM3A 1YJ3A 1M35A 3L24A 1C23A 2G6PA 2V3YA 2GU7A 4FKCA 3TAVA 3FMQA 4IKRA 2GTXA 5CIKA 4RZYA 1WKMA 3CB5A 4S01A 4FUKA 3TB5A 4U75A 4KM3A 4ZWPA 3PKBA 2GG7A 1C22A 3BIQA 1O0XA 2Q92A 1JAWA 4FLLA 3CB6A 1XGSA 4IECA 4QR8A 5D6EA 1MATA 2Q94A 2BWYA 1CHMA 4U76A 4U71A 2Q96A 5CDVA 1XNZA 4U70A 3BIPA 5FCFA 1C24A 4B28A 4ZNGA 3Q6DA 4IKUA 2GU4A 1R58A 2GG8A 3MR1A 2BWXA 2GGCA 4IF7A 5D6FA 5CDEA 2BH3A 2HOWA 2GG2A 1B59A 4IKSA 2P98A 4S2TP 1N51A 1R5HA 2GG5A 3MATA 3RORA 2ADUA 3CTZA 1W2MA 1C21A 1QXZA 1WL9A 3IU9A 4U73A 2BWWA 2GA2A 4FLIA 4U1BA 4EGEA 3PKAA 2V3ZA 1KQ9A 4FO8A 3L7GA 2EVMA 4IPAA 4FO7A 4OOKA 2EA4A 3PKDA 1XGOA 1C27A 1QXYA 2EA2A 4S00A 1B6AA 1WL6A
chains in the Genus database with same CATH superfamily
2OKNA 5JI6A 2BHBA 4U69A 2MATA 2NQ6A 1YW7A 2V3XA 1BN5A 1WN1A 2BWTA 5CNXA 2ZSGA 4R60A 2GZ5A 5CE6A 2B3HA 1Y1NA 1WBQA 2EVCA 3RVAA 2B3KA 4ZWUA 3MX6A 1XGNA 4U6EA 4A6VA 2BN7A 4U6WA 2NQ7A 4FLKA 4MATA 2GGBA 4U6ZA 2GG3A 4IU6A 5FCHA 4RGZ1 4HXXA 2Q93A 2P9AA 5JHUA 4PNCA 2IW2A 3PKCA 1YW9A 2EVOA 5E5BA 3PKEA 2BWSA 2B3LA 2V6CA 4IDYA 3IG4A 5CLSA 4IKTA 3S6BA 4U6CA 5JFRA 2DFIA 1WY2A 2BWVA 3D27A 4Z7MA 2BHDA 2GU6A 1KP0A 1XGMA 2GG0A 3FMRA 4PV4A 1QZYA 4A6WA 4U6JA 3IU7A 2GG9A 1QXWA 2Q95A 4RZZA 2Q8KA 5CDLA 2BB7A 1WLRA 1PV9A 3IU8A 2P99A 1KQ0A 2BHAA 1BOAA 4S2RP 4ZWOA 1W7VA 2BHCA 1YW8A 4FLJA 2OAZA 4JUQA 1A16A 1YVMA 2BWUA 1R5GA 2GU5A 3BITA 3FM3A 1YJ3A 1M35A 3L24A 1C23A 2G6PA 2V3YA 2GU7A 4FKCA 3TAVA 3FMQA 4IKRA 2GTXA 5CIKA 4RZYA 1WKMA 3CB5A 4S01A 4FUKA 3TB5A 4U75A 4KM3A 4ZWPA 3PKBA 2GG7A 1C22A 3BIQA 1O0XA 2Q92A 1JAWA 4FLLA 3CB6A 1XGSA 4IECA 4QR8A 5D6EA 1MATA 2Q94A 2BWYA 1CHMA 4U76A 4U71A 2Q96A 5CDVA 1XNZA 4U70A 3BIPA 5FCFA 1C24A 4B28A 4ZNGA 3Q6DA 4IKUA 2GU4A 1R58A 2GG8A 3MR1A 2BWXA 2GGCA 4IF7A 5D6FA 5CDEA 2BH3A 2HOWA 2GG2A 1B59A 4IKSA 2P98A 4S2TP 1N51A 1R5HA 2GG5A 3MATA 3RORA 2ADUA 3CTZA 1W2MA 1C21A 1QXZA 1WL9A 3IU9A 4U73A 2BWWA 2GA2A 4FLIA 4U1BA 4EGEA 3PKAA 2V3ZA 1KQ9A 4FO8A 3L7GA 2EVMA 4IPAA 4FO7A 4OOKA 2EA4A 3PKDA 1XGOA 1C27A 1QXYA 2EA2A 4S00A 1B6AA 1WL6A
chains in the Genus database with same CATH topology
2OKNA 5JI6A 2BHBA 4U69A 2MATA 2NQ6A 1YW7A 2V3XA 1BN5A 1WN1A 2BWTA 5CNXA 2ZSGA 4R60A 2GZ5A 5CE6A 2B3HA 1Y1NA 1WBQA 2EVCA 3RVAA 2B3KA 4ZWUA 3MX6A 1XGNA 4U6EA 4A6VA 2BN7A 4U6WA 2NQ7A 4FLKA 4MATA 2GGBA 4U6ZA 2GG3A 4IU6A 5FCHA 4RGZ1 4HXXA 2Q93A 2P9AA 5JHUA 4PNCA 2IW2A 3PKCA 1YW9A 2EVOA 5E5BA 3PKEA 2BWSA 2B3LA 2V6CA 4IDYA 3IG4A 5CLSA 4IKTA 3S6BA 4U6CA 5JFRA 2DFIA 1WY2A 2BWVA 3D27A 4Z7MA 2BHDA 2GU6A 1KP0A 1XGMA 2GG0A 3FMRA 4PV4A 1QZYA 4A6WA 4U6JA 3IU7A 2GG9A 1QXWA 2Q95A 4RZZA 2Q8KA 5CDLA 2BB7A 1WLRA 1PV9A 3IU8A 2P99A 1KQ0A 2BHAA 1BOAA 4S2RP 4ZWOA 1W7VA 2BHCA 1YW8A 4FLJA 2OAZA 4JUQA 1A16A 1YVMA 2BWUA 1R5GA 2GU5A 3BITA 3FM3A 1YJ3A 1M35A 3L24A 1C23A 2G6PA 2V3YA 2GU7A 4FKCA 3TAVA 3FMQA 4IKRA 2GTXA 5CIKA 4RZYA 1WKMA 3CB5A 4S01A 4FUKA 3TB5A 4U75A 4KM3A 4ZWPA 3PKBA 2GG7A 1C22A 3BIQA 1O0XA 2Q92A 1JAWA 4FLLA 3CB6A 1XGSA 4IECA 4QR8A 5D6EA 1MATA 2Q94A 2BWYA 1CHMA 4U76A 4U71A 2Q96A 5CDVA 1XNZA 4U70A 3BIPA 5FCFA 1C24A 4B28A 4ZNGA 3Q6DA 4IKUA 2GU4A 1R58A 2GG8A 3MR1A 2BWXA 2GGCA 4IF7A 5D6FA 5CDEA 2BH3A 2HOWA 2GG2A 1B59A 4IKSA 2P98A 4S2TP 1N51A 1R5HA 2GG5A 3MATA 3RORA 2ADUA 3CTZA 1W2MA 1C21A 1QXZA 1WL9A 3IU9A 4U73A 2BWWA 2GA2A 4FLIA 4U1BA 4EGEA 3PKAA 2V3ZA 1KQ9A 4FO8A 3L7GA 2EVMA 4IPAA 4FO7A 4OOKA 2EA4A 3PKDA 1XGOA 1C27A 1QXYA 2EA2A 4S00A 1B6AA 1WL6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OKN A;  5JI6 A;  2BHB A;  4U69 A;  2MAT A;  2NQ6 A;  1YW7 A;  2V3X A;  1BN5 A;  1WN1 A;  2BWT A;  5CNX A;  2ZSG A;  4R60 A;  2GZ5 A;  5CE6 A;  2B3H A;  1Y1N A;  1WBQ A;  2EVC A;  3RVA A;  2B3K A;  4ZWU A;  3MX6 A;  1XGN A;  4U6E A;  4A6V A;  2BN7 A;  4U6W A;  2NQ7 A;  4FLK A;  4MAT A;  2GGB A;  4U6Z A;  2GG3 A;  4IU6 A;  5FCH A;  4RGZ 1;  4HXX A;  2Q93 A;  2P9A A;  5JHU A;  4PNC A;  2IW2 A;  3PKC A;  1YW9 A;  2EVO A;  5E5B A;  3PKE A;  2BWS A;  2B3L A;  2V6C A;  4IDY A;  3IG4 A;  5CLS A;  4IKT A;  3S6B A;  4U6C A;  5JFR A;  2DFI A;  1WY2 A;  2BWV A;  3D27 A;  4Z7M A;  2BHD A;  2GU6 A;  1KP0 A;  1XGM A;  2GG0 A;  3FMR A;  4PV4 A;  1QZY A;  4A6W A;  4U6J A;  3IU7 A;  2GG9 A;  1QXW A;  2Q95 A;  4RZZ A;  2Q8K A;  5CDL A;  2BB7 A;  1WLR A;  1PV9 A;  3IU8 A;  2P99 A;  1KQ0 A;  2BHA A;  1BOA A;  4S2R P;  4ZWO A;  1W7V A;  2BHC A;  1YW8 A;  4FLJ A;  2OAZ A;  4JUQ A;  1A16 A;  1YVM A;  2BWU A;  1R5G A;  2GU5 A;  3BIT A;  3FM3 A;  1YJ3 A;  1M35 A;  3L24 A;  1C23 A;  2G6P A;  2V3Y A;  2GU7 A;  4FKC A;  3TAV A;  3FMQ A;  4IKR A;  2GTX A;  5CIK A;  4RZY A;  1WKM A;  3CB5 A;  4S01 A;  4FUK A;  3TB5 A;  4U75 A;  4KM3 A;  4ZWP A;  3PKB A;  2GG7 A;  1C22 A;  3BIQ A;  1O0X A;  2Q92 A;  1JAW A;  4FLL A;  3CB6 A;  1XGS A;  4IEC A;  4QR8 A;  5D6E A;  1MAT A;  2Q94 A;  2BWY A;  1CHM A;  4U76 A;  4U71 A;  2Q96 A;  5CDV A;  1XNZ A;  4U70 A;  3BIP A;  5FCF A;  1C24 A;  4B28 A;  4ZNG A;  3Q6D A;  4IKU A;  2GU4 A;  1R58 A;  2GG8 A;  3MR1 A;  2BWX A;  2GGC A;  4IF7 A;  5D6F A;  5CDE A;  2BH3 A;  2HOW A;  2GG2 A;  1B59 A;  4IKS A;  2P98 A;  4S2T P;  1N51 A;  1R5H A;  2GG5 A;  3MAT A;  3ROR A;  2ADU A;  3CTZ A;  1W2M A;  1C21 A;  1QXZ A;  1WL9 A;  3IU9 A;  4U73 A;  2BWW A;  2GA2 A;  4FLI A;  4U1B A;  4EGE A;  3PKA A;  2V3Z A;  1KQ9 A;  4FO8 A;  3L7G A;  2EVM A;  4IPA A;  4FO7 A;  4OOK A;  2EA4 A;  3PKD A;  1XGO A;  1C27 A;  1QXY A;  2EA2 A;  4S00 A;  1B6A A;  1WL6 A; 
#chains in the Genus database with same CATH topology
 2OKN A;  5JI6 A;  2BHB A;  4U69 A;  2MAT A;  2NQ6 A;  1YW7 A;  2V3X A;  1BN5 A;  1WN1 A;  2BWT A;  5CNX A;  2ZSG A;  4R60 A;  2GZ5 A;  5CE6 A;  2B3H A;  1Y1N A;  1WBQ A;  2EVC A;  3RVA A;  2B3K A;  4ZWU A;  3MX6 A;  1XGN A;  4U6E A;  4A6V A;  2BN7 A;  4U6W A;  2NQ7 A;  4FLK A;  4MAT A;  2GGB A;  4U6Z A;  2GG3 A;  4IU6 A;  5FCH A;  4RGZ 1;  4HXX A;  2Q93 A;  2P9A A;  5JHU A;  4PNC A;  2IW2 A;  3PKC A;  1YW9 A;  2EVO A;  5E5B A;  3PKE A;  2BWS A;  2B3L A;  2V6C A;  4IDY A;  3IG4 A;  5CLS A;  4IKT A;  3S6B A;  4U6C A;  5JFR A;  2DFI A;  1WY2 A;  2BWV A;  3D27 A;  4Z7M A;  2BHD A;  2GU6 A;  1KP0 A;  1XGM A;  2GG0 A;  3FMR A;  4PV4 A;  1QZY A;  4A6W A;  4U6J A;  3IU7 A;  2GG9 A;  1QXW A;  2Q95 A;  4RZZ A;  2Q8K A;  5CDL A;  2BB7 A;  1WLR A;  1PV9 A;  3IU8 A;  2P99 A;  1KQ0 A;  2BHA A;  1BOA A;  4S2R P;  4ZWO A;  1W7V A;  2BHC A;  1YW8 A;  4FLJ A;  2OAZ A;  4JUQ A;  1A16 A;  1YVM A;  2BWU A;  1R5G A;  2GU5 A;  3BIT A;  3FM3 A;  1YJ3 A;  1M35 A;  3L24 A;  1C23 A;  2G6P A;  2V3Y A;  2GU7 A;  4FKC A;  3TAV A;  3FMQ A;  4IKR A;  2GTX A;  5CIK A;  4RZY A;  1WKM A;  3CB5 A;  4S01 A;  4FUK A;  3TB5 A;  4U75 A;  4KM3 A;  4ZWP A;  3PKB A;  2GG7 A;  1C22 A;  3BIQ A;  1O0X A;  2Q92 A;  1JAW A;  4FLL A;  3CB6 A;  1XGS A;  4IEC A;  4QR8 A;  5D6E A;  1MAT A;  2Q94 A;  2BWY A;  1CHM A;  4U76 A;  4U71 A;  2Q96 A;  5CDV A;  1XNZ A;  4U70 A;  3BIP A;  5FCF A;  1C24 A;  4B28 A;  4ZNG A;  3Q6D A;  4IKU A;  2GU4 A;  1R58 A;  2GG8 A;  3MR1 A;  2BWX A;  2GGC A;  4IF7 A;  5D6F A;  5CDE A;  2BH3 A;  2HOW A;  2GG2 A;  1B59 A;  4IKS A;  2P98 A;  4S2T P;  1N51 A;  1R5H A;  2GG5 A;  3MAT A;  3ROR A;  2ADU A;  3CTZ A;  1W2M A;  1C21 A;  1QXZ A;  1WL9 A;  3IU9 A;  4U73 A;  2BWW A;  2GA2 A;  4FLI A;  4U1B A;  4EGE A;  3PKA A;  2V3Z A;  1KQ9 A;  4FO8 A;  3L7G A;  2EVM A;  4IPA A;  4FO7 A;  4OOK A;  2EA4 A;  3PKD A;  1XGO A;  1C27 A;  1QXY A;  2EA2 A;  4S00 A;  1B6A A;  1WL6 A; 
#chains in the Genus database with same CATH homology
 2OKN A;  5JI6 A;  2BHB A;  4U69 A;  2MAT A;  2NQ6 A;  1YW7 A;  2V3X A;  1BN5 A;  1WN1 A;  2BWT A;  5CNX A;  2ZSG A;  4R60 A;  2GZ5 A;  5CE6 A;  2B3H A;  1Y1N A;  1WBQ A;  2EVC A;  3RVA A;  2B3K A;  4ZWU A;  3MX6 A;  1XGN A;  4U6E A;  4A6V A;  2BN7 A;  4U6W A;  2NQ7 A;  4FLK A;  4MAT A;  2GGB A;  4U6Z A;  2GG3 A;  4IU6 A;  5FCH A;  4RGZ 1;  4HXX A;  2Q93 A;  2P9A A;  5JHU A;  4PNC A;  2IW2 A;  3PKC A;  1YW9 A;  2EVO A;  5E5B A;  3PKE A;  2BWS A;  2B3L A;  2V6C A;  4IDY A;  3IG4 A;  5CLS A;  4IKT A;  3S6B A;  4U6C A;  5JFR A;  2DFI A;  1WY2 A;  2BWV A;  3D27 A;  4Z7M A;  2BHD A;  2GU6 A;  1KP0 A;  1XGM A;  2GG0 A;  3FMR A;  4PV4 A;  1QZY A;  4A6W A;  4U6J A;  3IU7 A;  2GG9 A;  1QXW A;  2Q95 A;  4RZZ A;  2Q8K A;  5CDL A;  2BB7 A;  1WLR A;  1PV9 A;  3IU8 A;  2P99 A;  1KQ0 A;  2BHA A;  1BOA A;  4S2R P;  4ZWO A;  1W7V A;  2BHC A;  1YW8 A;  4FLJ A;  2OAZ A;  4JUQ A;  1A16 A;  1YVM A;  2BWU A;  1R5G A;  2GU5 A;  3BIT A;  3FM3 A;  1YJ3 A;  1M35 A;  3L24 A;  1C23 A;  2G6P A;  2V3Y A;  2GU7 A;  4FKC A;  3TAV A;  3FMQ A;  4IKR A;  2GTX A;  5CIK A;  4RZY A;  1WKM A;  3CB5 A;  4S01 A;  4FUK A;  3TB5 A;  4U75 A;  4KM3 A;  4ZWP A;  3PKB A;  2GG7 A;  1C22 A;  3BIQ A;  1O0X A;  2Q92 A;  1JAW A;  4FLL A;  3CB6 A;  1XGS A;  4IEC A;  4QR8 A;  5D6E A;  1MAT A;  2Q94 A;  2BWY A;  1CHM A;  4U76 A;  4U71 A;  2Q96 A;  5CDV A;  1XNZ A;  4U70 A;  3BIP A;  5FCF A;  1C24 A;  4B28 A;  4ZNG A;  3Q6D A;  4IKU A;  2GU4 A;  1R58 A;  2GG8 A;  3MR1 A;  2BWX A;  2GGC A;  4IF7 A;  5D6F A;  5CDE A;  2BH3 A;  2HOW A;  2GG2 A;  1B59 A;  4IKS A;  2P98 A;  4S2T P;  1N51 A;  1R5H A;  2GG5 A;  3MAT A;  3ROR A;  2ADU A;  3CTZ A;  1W2M A;  1C21 A;  1QXZ A;  1WL9 A;  3IU9 A;  4U73 A;  2BWW A;  2GA2 A;  4FLI A;  4U1B A;  4EGE A;  3PKA A;  2V3Z A;  1KQ9 A;  4FO8 A;  3L7G A;  2EVM A;  4IPA A;  4FO7 A;  4OOK A;  2EA4 A;  3PKD A;  1XGO A;  1C27 A;  1QXY A;  2EA2 A;  4S00 A;  1B6A A;  1WL6 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...