2GGBA

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
source organism Escherichia coli k12
molecule tags Hydrolase
total genus 84
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2ggbA00
3MX6A 3CB5A 2V6CA 1WLRA 4IKRA 4U1BA 3PKAA 3TAVA 4A6WA 1MATA 1KQ9A 4RGZ1 4MATA 4S01A 2ZSGA 4U75A 3BITA 1XGSA 3L7GA 5CIKA 2Q8KA 3RVAA 5FCHA 1YW8A 4U6WA 5CE6A 1M35A 1WN1A 2B3KA 2BWWA 4U6ZA 1QXZA 2GU4A 1WY2A 4IKSA 1W7VA 3L24A 1XNZA 4U6CA 1XGOA 2BH3A 5CNXA 4FO8A 2BWTA 4S2TP 2GG9A 1Y1NA 4PNCA 4U76A 4ZWUA 2EA2A 1C27A 1R5GA 2HOWA 1JAWA 2V3XA 5JI6A 3IU7A 3PKEA 5CDEA 4IDYA 1XGMA 4HXXA 2GGCA 1YW7A 3CTZA 2GGBA 3Q6DA 5FCFA 2Q95A 2P9AA 4R60A 5JHUA 2Q93A 4U70A 1KQ0A 5D6EA 1PV9A 4ZWPA 1YVMA 1BOAA 1CHMA 2B3LA 2GU7A 2V3ZA 4JUQA 2GZ5A 2EA4A 1R5HA 4IECA 1B6AA 2GG5A 4S2RP 5D6FA 4IKTA 2BB7A 4KM3A 2BHDA 3TB5A 2GA2A 1O0XA 1YW9A 5CDVA 2BWXA 1WL9A 2Q94A 2BN7A 2GG2A 4IF7A 2OAZA 3D27A 2GU6A 2NQ7A 2G6PA 2EVCA 2B3HA 4EGEA 2NQ6A 4RZZA 4RZYA 3MR1A 2BHBA 1KP0A 4FO7A 4S00A 2EVMA 2GG3A 4IU6A 1XGNA 2ADUA 2Q92A 3IU8A 2BHAA 3BIPA 1QXYA 4B28A 4FLIA 4PV4A 4FLLA 3PKBA 1N51A 4Z7MA 2GTXA 3IG4A 2GU5A 3PKCA 1C22A 3PKDA 4FLJA 4ZNGA 4FLKA 1W2MA 4IKUA 1C24A 4U69A 2BWUA 2P99A 4U71A 5CLSA 1A16A 2GG8A 2BWVA 2GG7A 3FM3A 1C21A 2OKNA 3FMQA 1QXWA 2DFIA 4U73A 2EVOA 4ZWOA 4A6VA 3MATA 1R58A 2GG0A 3FMRA 2V3YA 2IW2A 2MATA 4OOKA 5E5BA 1B59A 2Q96A 2P98A 2BHCA 3CB6A 1QZYA 3RORA 2BWSA 1C23A 2BWYA 3IU9A 4IPAA 5CDLA 1YJ3A 1BN5A 4U6EA 4U6JA 1WKMA 4FUKA 3S6BA 4FKCA 1WL6A 3BIQA 1WBQA 4QR8A 5JFRA
chains in the Genus database with same CATH superfamily
3MX6A 3CB5A 2V6CA 1WLRA 4IKRA 4U1BA 3PKAA 3TAVA 4A6WA 1MATA 1KQ9A 4RGZ1 4MATA 4S01A 2ZSGA 4U75A 3BITA 1XGSA 3L7GA 5CIKA 2Q8KA 3RVAA 5FCHA 1YW8A 4U6WA 5CE6A 1M35A 1WN1A 2B3KA 2BWWA 4U6ZA 1QXZA 2GU4A 1WY2A 4IKSA 1W7VA 3L24A 1XNZA 4U6CA 1XGOA 2BH3A 5CNXA 4FO8A 2BWTA 4S2TP 2GG9A 1Y1NA 4PNCA 4U76A 4ZWUA 2EA2A 1C27A 1R5GA 2HOWA 1JAWA 2V3XA 5JI6A 3IU7A 3PKEA 5CDEA 4IDYA 1XGMA 4HXXA 2GGCA 1YW7A 3CTZA 2GGBA 3Q6DA 5FCFA 2Q95A 2P9AA 4R60A 5JHUA 2Q93A 4U70A 1KQ0A 5D6EA 1PV9A 4ZWPA 1YVMA 1BOAA 1CHMA 2B3LA 2GU7A 2V3ZA 4JUQA 2GZ5A 2EA4A 1R5HA 4IECA 1B6AA 2GG5A 4S2RP 5D6FA 4IKTA 2BB7A 4KM3A 2BHDA 3TB5A 2GA2A 1O0XA 1YW9A 5CDVA 2BWXA 1WL9A 2Q94A 2BN7A 2GG2A 4IF7A 2OAZA 3D27A 2GU6A 2NQ7A 2G6PA 2EVCA 2B3HA 4EGEA 2NQ6A 4RZZA 4RZYA 3MR1A 2BHBA 1KP0A 4FO7A 4S00A 2EVMA 2GG3A 4IU6A 1XGNA 2ADUA 2Q92A 3IU8A 2BHAA 3BIPA 1QXYA 4B28A 4FLIA 4PV4A 4FLLA 3PKBA 1N51A 4Z7MA 2GTXA 3IG4A 2GU5A 3PKCA 1C22A 3PKDA 4FLJA 4ZNGA 4FLKA 1W2MA 4IKUA 1C24A 4U69A 2BWUA 2P99A 4U71A 5CLSA 1A16A 2GG8A 2BWVA 2GG7A 3FM3A 1C21A 2OKNA 3FMQA 1QXWA 2DFIA 4U73A 2EVOA 4ZWOA 4A6VA 3MATA 1R58A 2GG0A 3FMRA 2V3YA 2IW2A 2MATA 4OOKA 5E5BA 1B59A 2Q96A 2P98A 2BHCA 3CB6A 1QZYA 3RORA 2BWSA 1C23A 2BWYA 3IU9A 4IPAA 5CDLA 1YJ3A 1BN5A 4U6EA 4U6JA 1WKMA 4FUKA 3S6BA 4FKCA 1WL6A 3BIQA 1WBQA 4QR8A 5JFRA
chains in the Genus database with same CATH topology
3MX6A 3CB5A 2V6CA 1WLRA 4IKRA 4U1BA 3PKAA 3TAVA 4A6WA 1MATA 1KQ9A 4RGZ1 4MATA 4S01A 2ZSGA 4U75A 3BITA 1XGSA 3L7GA 5CIKA 2Q8KA 3RVAA 5FCHA 1YW8A 4U6WA 5CE6A 1M35A 1WN1A 2B3KA 2BWWA 4U6ZA 1QXZA 2GU4A 1WY2A 4IKSA 1W7VA 3L24A 1XNZA 4U6CA 1XGOA 2BH3A 5CNXA 4FO8A 2BWTA 4S2TP 2GG9A 1Y1NA 4PNCA 4U76A 4ZWUA 2EA2A 1C27A 1R5GA 2HOWA 1JAWA 2V3XA 5JI6A 3IU7A 3PKEA 5CDEA 4IDYA 1XGMA 4HXXA 2GGCA 1YW7A 3CTZA 2GGBA 3Q6DA 5FCFA 2Q95A 2P9AA 4R60A 5JHUA 2Q93A 4U70A 1KQ0A 5D6EA 1PV9A 4ZWPA 1YVMA 1BOAA 1CHMA 2B3LA 2GU7A 2V3ZA 4JUQA 2GZ5A 2EA4A 1R5HA 4IECA 1B6AA 2GG5A 4S2RP 5D6FA 4IKTA 2BB7A 4KM3A 2BHDA 3TB5A 2GA2A 1O0XA 1YW9A 5CDVA 2BWXA 1WL9A 2Q94A 2BN7A 2GG2A 4IF7A 2OAZA 3D27A 2GU6A 2NQ7A 2G6PA 2EVCA 2B3HA 4EGEA 2NQ6A 4RZZA 4RZYA 3MR1A 2BHBA 1KP0A 4FO7A 4S00A 2EVMA 2GG3A 4IU6A 1XGNA 2ADUA 2Q92A 3IU8A 2BHAA 3BIPA 1QXYA 4B28A 4FLIA 4PV4A 4FLLA 3PKBA 1N51A 4Z7MA 2GTXA 3IG4A 2GU5A 3PKCA 1C22A 3PKDA 4FLJA 4ZNGA 4FLKA 1W2MA 4IKUA 1C24A 4U69A 2BWUA 2P99A 4U71A 5CLSA 1A16A 2GG8A 2BWVA 2GG7A 3FM3A 1C21A 2OKNA 3FMQA 1QXWA 2DFIA 4U73A 2EVOA 4ZWOA 4A6VA 3MATA 1R58A 2GG0A 3FMRA 2V3YA 2IW2A 2MATA 4OOKA 5E5BA 1B59A 2Q96A 2P98A 2BHCA 3CB6A 1QZYA 3RORA 2BWSA 1C23A 2BWYA 3IU9A 4IPAA 5CDLA 1YJ3A 1BN5A 4U6EA 4U6JA 1WKMA 4FUKA 3S6BA 4FKCA 1WL6A 3BIQA 1WBQA 4QR8A 5JFRA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3MX6 A;  3CB5 A;  2V6C A;  1WLR A;  4IKR A;  4U1B A;  3PKA A;  3TAV A;  4A6W A;  1MAT A;  1KQ9 A;  4RGZ 1;  4MAT A;  4S01 A;  2ZSG A;  4U75 A;  3BIT A;  1XGS A;  3L7G A;  5CIK A;  2Q8K A;  3RVA A;  5FCH A;  1YW8 A;  4U6W A;  5CE6 A;  1M35 A;  1WN1 A;  2B3K A;  2BWW A;  4U6Z A;  1QXZ A;  2GU4 A;  1WY2 A;  4IKS A;  1W7V A;  3L24 A;  1XNZ A;  4U6C A;  1XGO A;  2BH3 A;  5CNX A;  4FO8 A;  2BWT A;  4S2T P;  2GG9 A;  1Y1N A;  4PNC A;  4U76 A;  4ZWU A;  2EA2 A;  1C27 A;  1R5G A;  2HOW A;  1JAW A;  2V3X A;  5JI6 A;  3IU7 A;  3PKE A;  5CDE A;  4IDY A;  1XGM A;  4HXX A;  2GGC A;  1YW7 A;  3CTZ A;  2GGB A;  3Q6D A;  5FCF A;  2Q95 A;  2P9A A;  4R60 A;  5JHU A;  2Q93 A;  4U70 A;  1KQ0 A;  5D6E A;  1PV9 A;  4ZWP A;  1YVM A;  1BOA A;  1CHM A;  2B3L A;  2GU7 A;  2V3Z A;  4JUQ A;  2GZ5 A;  2EA4 A;  1R5H A;  4IEC A;  1B6A A;  2GG5 A;  4S2R P;  5D6F A;  4IKT A;  2BB7 A;  4KM3 A;  2BHD A;  3TB5 A;  2GA2 A;  1O0X A;  1YW9 A;  5CDV A;  2BWX A;  1WL9 A;  2Q94 A;  2BN7 A;  2GG2 A;  4IF7 A;  2OAZ A;  3D27 A;  2GU6 A;  2NQ7 A;  2G6P A;  2EVC A;  2B3H A;  4EGE A;  2NQ6 A;  4RZZ A;  4RZY A;  3MR1 A;  2BHB A;  1KP0 A;  4FO7 A;  4S00 A;  2EVM A;  2GG3 A;  4IU6 A;  1XGN A;  2ADU A;  2Q92 A;  3IU8 A;  2BHA A;  3BIP A;  1QXY A;  4B28 A;  4FLI A;  4PV4 A;  4FLL A;  3PKB A;  1N51 A;  4Z7M A;  2GTX A;  3IG4 A;  2GU5 A;  3PKC A;  1C22 A;  3PKD A;  4FLJ A;  4ZNG A;  4FLK A;  1W2M A;  4IKU A;  1C24 A;  4U69 A;  2BWU A;  2P99 A;  4U71 A;  5CLS A;  1A16 A;  2GG8 A;  2BWV A;  2GG7 A;  3FM3 A;  1C21 A;  2OKN A;  3FMQ A;  1QXW A;  2DFI A;  4U73 A;  2EVO A;  4ZWO A;  4A6V A;  3MAT A;  1R58 A;  2GG0 A;  3FMR A;  2V3Y A;  2IW2 A;  2MAT A;  4OOK A;  5E5B A;  1B59 A;  2Q96 A;  2P98 A;  2BHC A;  3CB6 A;  1QZY A;  3ROR A;  2BWS A;  1C23 A;  2BWY A;  3IU9 A;  4IPA A;  5CDL A;  1YJ3 A;  1BN5 A;  4U6E A;  4U6J A;  1WKM A;  4FUK A;  3S6B A;  4FKC A;  1WL6 A;  3BIQ A;  1WBQ A;  4QR8 A;  5JFR A; 
#chains in the Genus database with same CATH topology
 3MX6 A;  3CB5 A;  2V6C A;  1WLR A;  4IKR A;  4U1B A;  3PKA A;  3TAV A;  4A6W A;  1MAT A;  1KQ9 A;  4RGZ 1;  4MAT A;  4S01 A;  2ZSG A;  4U75 A;  3BIT A;  1XGS A;  3L7G A;  5CIK A;  2Q8K A;  3RVA A;  5FCH A;  1YW8 A;  4U6W A;  5CE6 A;  1M35 A;  1WN1 A;  2B3K A;  2BWW A;  4U6Z A;  1QXZ A;  2GU4 A;  1WY2 A;  4IKS A;  1W7V A;  3L24 A;  1XNZ A;  4U6C A;  1XGO A;  2BH3 A;  5CNX A;  4FO8 A;  2BWT A;  4S2T P;  2GG9 A;  1Y1N A;  4PNC A;  4U76 A;  4ZWU A;  2EA2 A;  1C27 A;  1R5G A;  2HOW A;  1JAW A;  2V3X A;  5JI6 A;  3IU7 A;  3PKE A;  5CDE A;  4IDY A;  1XGM A;  4HXX A;  2GGC A;  1YW7 A;  3CTZ A;  2GGB A;  3Q6D A;  5FCF A;  2Q95 A;  2P9A A;  4R60 A;  5JHU A;  2Q93 A;  4U70 A;  1KQ0 A;  5D6E A;  1PV9 A;  4ZWP A;  1YVM A;  1BOA A;  1CHM A;  2B3L A;  2GU7 A;  2V3Z A;  4JUQ A;  2GZ5 A;  2EA4 A;  1R5H A;  4IEC A;  1B6A A;  2GG5 A;  4S2R P;  5D6F A;  4IKT A;  2BB7 A;  4KM3 A;  2BHD A;  3TB5 A;  2GA2 A;  1O0X A;  1YW9 A;  5CDV A;  2BWX A;  1WL9 A;  2Q94 A;  2BN7 A;  2GG2 A;  4IF7 A;  2OAZ A;  3D27 A;  2GU6 A;  2NQ7 A;  2G6P A;  2EVC A;  2B3H A;  4EGE A;  2NQ6 A;  4RZZ A;  4RZY A;  3MR1 A;  2BHB A;  1KP0 A;  4FO7 A;  4S00 A;  2EVM A;  2GG3 A;  4IU6 A;  1XGN A;  2ADU A;  2Q92 A;  3IU8 A;  2BHA A;  3BIP A;  1QXY A;  4B28 A;  4FLI A;  4PV4 A;  4FLL A;  3PKB A;  1N51 A;  4Z7M A;  2GTX A;  3IG4 A;  2GU5 A;  3PKC A;  1C22 A;  3PKD A;  4FLJ A;  4ZNG A;  4FLK A;  1W2M A;  4IKU A;  1C24 A;  4U69 A;  2BWU A;  2P99 A;  4U71 A;  5CLS A;  1A16 A;  2GG8 A;  2BWV A;  2GG7 A;  3FM3 A;  1C21 A;  2OKN A;  3FMQ A;  1QXW A;  2DFI A;  4U73 A;  2EVO A;  4ZWO A;  4A6V A;  3MAT A;  1R58 A;  2GG0 A;  3FMR A;  2V3Y A;  2IW2 A;  2MAT A;  4OOK A;  5E5B A;  1B59 A;  2Q96 A;  2P98 A;  2BHC A;  3CB6 A;  1QZY A;  3ROR A;  2BWS A;  1C23 A;  2BWY A;  3IU9 A;  4IPA A;  5CDL A;  1YJ3 A;  1BN5 A;  4U6E A;  4U6J A;  1WKM A;  4FUK A;  3S6B A;  4FKC A;  1WL6 A;  3BIQ A;  1WBQ A;  4QR8 A;  5JFR A; 
#chains in the Genus database with same CATH homology
 3MX6 A;  3CB5 A;  2V6C A;  1WLR A;  4IKR A;  4U1B A;  3PKA A;  3TAV A;  4A6W A;  1MAT A;  1KQ9 A;  4RGZ 1;  4MAT A;  4S01 A;  2ZSG A;  4U75 A;  3BIT A;  1XGS A;  3L7G A;  5CIK A;  2Q8K A;  3RVA A;  5FCH A;  1YW8 A;  4U6W A;  5CE6 A;  1M35 A;  1WN1 A;  2B3K A;  2BWW A;  4U6Z A;  1QXZ A;  2GU4 A;  1WY2 A;  4IKS A;  1W7V A;  3L24 A;  1XNZ A;  4U6C A;  1XGO A;  2BH3 A;  5CNX A;  4FO8 A;  2BWT A;  4S2T P;  2GG9 A;  1Y1N A;  4PNC A;  4U76 A;  4ZWU A;  2EA2 A;  1C27 A;  1R5G A;  2HOW A;  1JAW A;  2V3X A;  5JI6 A;  3IU7 A;  3PKE A;  5CDE A;  4IDY A;  1XGM A;  4HXX A;  2GGC A;  1YW7 A;  3CTZ A;  2GGB A;  3Q6D A;  5FCF A;  2Q95 A;  2P9A A;  4R60 A;  5JHU A;  2Q93 A;  4U70 A;  1KQ0 A;  5D6E A;  1PV9 A;  4ZWP A;  1YVM A;  1BOA A;  1CHM A;  2B3L A;  2GU7 A;  2V3Z A;  4JUQ A;  2GZ5 A;  2EA4 A;  1R5H A;  4IEC A;  1B6A A;  2GG5 A;  4S2R P;  5D6F A;  4IKT A;  2BB7 A;  4KM3 A;  2BHD A;  3TB5 A;  2GA2 A;  1O0X A;  1YW9 A;  5CDV A;  2BWX A;  1WL9 A;  2Q94 A;  2BN7 A;  2GG2 A;  4IF7 A;  2OAZ A;  3D27 A;  2GU6 A;  2NQ7 A;  2G6P A;  2EVC A;  2B3H A;  4EGE A;  2NQ6 A;  4RZZ A;  4RZY A;  3MR1 A;  2BHB A;  1KP0 A;  4FO7 A;  4S00 A;  2EVM A;  2GG3 A;  4IU6 A;  1XGN A;  2ADU A;  2Q92 A;  3IU8 A;  2BHA A;  3BIP A;  1QXY A;  4B28 A;  4FLI A;  4PV4 A;  4FLL A;  3PKB A;  1N51 A;  4Z7M A;  2GTX A;  3IG4 A;  2GU5 A;  3PKC A;  1C22 A;  3PKD A;  4FLJ A;  4ZNG A;  4FLK A;  1W2M A;  4IKU A;  1C24 A;  4U69 A;  2BWU A;  2P99 A;  4U71 A;  5CLS A;  1A16 A;  2GG8 A;  2BWV A;  2GG7 A;  3FM3 A;  1C21 A;  2OKN A;  3FMQ A;  1QXW A;  2DFI A;  4U73 A;  2EVO A;  4ZWO A;  4A6V A;  3MAT A;  1R58 A;  2GG0 A;  3FMR A;  2V3Y A;  2IW2 A;  2MAT A;  4OOK A;  5E5B A;  1B59 A;  2Q96 A;  2P98 A;  2BHC A;  3CB6 A;  1QZY A;  3ROR A;  2BWS A;  1C23 A;  2BWY A;  3IU9 A;  4IPA A;  5CDL A;  1YJ3 A;  1BN5 A;  4U6E A;  4U6J A;  1WKM A;  4FUK A;  3S6B A;  4FKC A;  1WL6 A;  3BIQ A;  1WBQ A;  4QR8 A;  5JFR A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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