2GGCA

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 87
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2ggcA00
1R5GA 1M35A 3TB5A 4U69A 3BIQA 4R60A 2Q95A 1KP0A 1R5HA 1WL6A 4RZZA 3BITA 4IKSA 3BIPA 4OOKA 2GG5A 5D6EA 4FKCA 2BH3A 2GG8A 2GU5A 5CDVA 3PKDA 2BHDA 1XGNA 5CIKA 1QXWA 3IU7A 4S01A 4U6WA 2BHCA 2GGCA 1XGOA 1O0XA 4MATA 3S6BA 1C24A 2DFIA 3MATA 3PKAA 4U6JA 2Q94A 4FUKA 4S00A 4IU6A 2P99A 4A6WA 3FMQA 1YW9A 2V3XA 1WL9A 4RGZ1 4S2TP 5JHUA 2GGBA 4U73A 1B59A 1WKMA 2BWTA 2V6CA 3L7GA 4Z7MA 2P9AA 1WBQA 4FLIA 4A6VA 4IPAA 3FM3A 3MR1A 1N51A 3PKEA 2Q92A 3TAVA 4FLKA 2EA4A 3MX6A 2GZ5A 1JAWA 2G6PA 4ZWPA 2GU7A 4IDYA 1W2MA 2BWVA 4IKTA 1XNZA 4FLLA 2OAZA 2GG2A 2NQ7A 2B3HA 1YJ3A 1R58A 4U6ZA 1C23A 4IECA 4ZWOA 3FMRA 2BHBA 2V3YA 2BWSA 4B28A 3L24A 2GG9A 2EA2A 3IU9A 4KM3A 4PNCA 3RVAA 1Y1NA 2BWXA 4FO7A 3IG4A 2BN7A 1YVMA 2MATA 5CDLA 1KQ9A 1W7VA 1BN5A 5JFRA 2BB7A 2GG0A 1CHMA 4HXXA 2EVMA 2EVOA 2BWYA 4IKRA 4PV4A 4U75A 4ZWUA 5JI6A 3CB5A 1B6AA 1C21A 3D27A 1WLRA 2IW2A 2GU6A 1C27A 5CDEA 1BOAA 1A16A 2V3ZA 2B3KA 3PKBA 4U71A 4U1BA 2GG7A 1C22A 2BWUA 1XGSA 2ZSGA 2EVCA 1YW7A 4IKUA 1YW8A 1MATA 2P98A 2GG3A 4IF7A 2Q93A 3PKCA 5FCHA 3CB6A 2B3LA 1QXZA 3RORA 4U6CA 5E5BA 2Q96A 4U76A 1XGMA 4U70A 2NQ6A 3CTZA 1WY2A 2ADUA 2GTXA 1WN1A 2BHAA 4FO8A 2BWWA 2GU4A 5CE6A 4ZNGA 5CNXA 4EGEA 4RZYA 4S2RP 1QZYA 2HOWA 4FLJA 4U6EA 1PV9A 1QXYA 2OKNA 2GA2A 5CLSA 4JUQA 5D6FA 2Q8KA 1KQ0A 4QR8A 3Q6DA 5FCFA 3IU8A
chains in the Genus database with same CATH superfamily
1R5GA 1M35A 3TB5A 4U69A 3BIQA 4R60A 2Q95A 1KP0A 1R5HA 1WL6A 4RZZA 3BITA 4IKSA 3BIPA 4OOKA 2GG5A 5D6EA 4FKCA 2BH3A 2GG8A 2GU5A 5CDVA 3PKDA 2BHDA 1XGNA 5CIKA 1QXWA 3IU7A 4S01A 4U6WA 2BHCA 2GGCA 1XGOA 1O0XA 4MATA 3S6BA 1C24A 2DFIA 3MATA 3PKAA 4U6JA 2Q94A 4FUKA 4S00A 4IU6A 2P99A 4A6WA 3FMQA 1YW9A 2V3XA 1WL9A 4RGZ1 4S2TP 5JHUA 2GGBA 4U73A 1B59A 1WKMA 2BWTA 2V6CA 3L7GA 4Z7MA 2P9AA 1WBQA 4FLIA 4A6VA 4IPAA 3FM3A 3MR1A 1N51A 3PKEA 2Q92A 3TAVA 4FLKA 2EA4A 3MX6A 2GZ5A 1JAWA 2G6PA 4ZWPA 2GU7A 4IDYA 1W2MA 2BWVA 4IKTA 1XNZA 4FLLA 2OAZA 2GG2A 2NQ7A 2B3HA 1YJ3A 1R58A 4U6ZA 1C23A 4IECA 4ZWOA 3FMRA 2BHBA 2V3YA 2BWSA 4B28A 3L24A 2GG9A 2EA2A 3IU9A 4KM3A 4PNCA 3RVAA 1Y1NA 2BWXA 4FO7A 3IG4A 2BN7A 1YVMA 2MATA 5CDLA 1KQ9A 1W7VA 1BN5A 5JFRA 2BB7A 2GG0A 1CHMA 4HXXA 2EVMA 2EVOA 2BWYA 4IKRA 4PV4A 4U75A 4ZWUA 5JI6A 3CB5A 1B6AA 1C21A 3D27A 1WLRA 2IW2A 2GU6A 1C27A 5CDEA 1BOAA 1A16A 2V3ZA 2B3KA 3PKBA 4U71A 4U1BA 2GG7A 1C22A 2BWUA 1XGSA 2ZSGA 2EVCA 1YW7A 4IKUA 1YW8A 1MATA 2P98A 2GG3A 4IF7A 2Q93A 3PKCA 5FCHA 3CB6A 2B3LA 1QXZA 3RORA 4U6CA 5E5BA 2Q96A 4U76A 1XGMA 4U70A 2NQ6A 3CTZA 1WY2A 2ADUA 2GTXA 1WN1A 2BHAA 4FO8A 2BWWA 2GU4A 5CE6A 4ZNGA 5CNXA 4EGEA 4RZYA 4S2RP 1QZYA 2HOWA 4FLJA 4U6EA 1PV9A 1QXYA 2OKNA 2GA2A 5CLSA 4JUQA 5D6FA 2Q8KA 1KQ0A 4QR8A 3Q6DA 5FCFA 3IU8A
chains in the Genus database with same CATH topology
1R5GA 1M35A 3TB5A 4U69A 3BIQA 4R60A 2Q95A 1KP0A 1R5HA 1WL6A 4RZZA 3BITA 4IKSA 3BIPA 4OOKA 2GG5A 5D6EA 4FKCA 2BH3A 2GG8A 2GU5A 5CDVA 3PKDA 2BHDA 1XGNA 5CIKA 1QXWA 3IU7A 4S01A 4U6WA 2BHCA 2GGCA 1XGOA 1O0XA 4MATA 3S6BA 1C24A 2DFIA 3MATA 3PKAA 4U6JA 2Q94A 4FUKA 4S00A 4IU6A 2P99A 4A6WA 3FMQA 1YW9A 2V3XA 1WL9A 4RGZ1 4S2TP 5JHUA 2GGBA 4U73A 1B59A 1WKMA 2BWTA 2V6CA 3L7GA 4Z7MA 2P9AA 1WBQA 4FLIA 4A6VA 4IPAA 3FM3A 3MR1A 1N51A 3PKEA 2Q92A 3TAVA 4FLKA 2EA4A 3MX6A 2GZ5A 1JAWA 2G6PA 4ZWPA 2GU7A 4IDYA 1W2MA 2BWVA 4IKTA 1XNZA 4FLLA 2OAZA 2GG2A 2NQ7A 2B3HA 1YJ3A 1R58A 4U6ZA 1C23A 4IECA 4ZWOA 3FMRA 2BHBA 2V3YA 2BWSA 4B28A 3L24A 2GG9A 2EA2A 3IU9A 4KM3A 4PNCA 3RVAA 1Y1NA 2BWXA 4FO7A 3IG4A 2BN7A 1YVMA 2MATA 5CDLA 1KQ9A 1W7VA 1BN5A 5JFRA 2BB7A 2GG0A 1CHMA 4HXXA 2EVMA 2EVOA 2BWYA 4IKRA 4PV4A 4U75A 4ZWUA 5JI6A 3CB5A 1B6AA 1C21A 3D27A 1WLRA 2IW2A 2GU6A 1C27A 5CDEA 1BOAA 1A16A 2V3ZA 2B3KA 3PKBA 4U71A 4U1BA 2GG7A 1C22A 2BWUA 1XGSA 2ZSGA 2EVCA 1YW7A 4IKUA 1YW8A 1MATA 2P98A 2GG3A 4IF7A 2Q93A 3PKCA 5FCHA 3CB6A 2B3LA 1QXZA 3RORA 4U6CA 5E5BA 2Q96A 4U76A 1XGMA 4U70A 2NQ6A 3CTZA 1WY2A 2ADUA 2GTXA 1WN1A 2BHAA 4FO8A 2BWWA 2GU4A 5CE6A 4ZNGA 5CNXA 4EGEA 4RZYA 4S2RP 1QZYA 2HOWA 4FLJA 4U6EA 1PV9A 1QXYA 2OKNA 2GA2A 5CLSA 4JUQA 5D6FA 2Q8KA 1KQ0A 4QR8A 3Q6DA 5FCFA 3IU8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1R5G A;  1M35 A;  3TB5 A;  4U69 A;  3BIQ A;  4R60 A;  2Q95 A;  1KP0 A;  1R5H A;  1WL6 A;  4RZZ A;  3BIT A;  4IKS A;  3BIP A;  4OOK A;  2GG5 A;  5D6E A;  4FKC A;  2BH3 A;  2GG8 A;  2GU5 A;  5CDV A;  3PKD A;  2BHD A;  1XGN A;  5CIK A;  1QXW A;  3IU7 A;  4S01 A;  4U6W A;  2BHC A;  2GGC A;  1XGO A;  1O0X A;  4MAT A;  3S6B A;  1C24 A;  2DFI A;  3MAT A;  3PKA A;  4U6J A;  2Q94 A;  4FUK A;  4S00 A;  4IU6 A;  2P99 A;  4A6W A;  3FMQ A;  1YW9 A;  2V3X A;  1WL9 A;  4RGZ 1;  4S2T P;  5JHU A;  2GGB A;  4U73 A;  1B59 A;  1WKM A;  2BWT A;  2V6C A;  3L7G A;  4Z7M A;  2P9A A;  1WBQ A;  4FLI A;  4A6V A;  4IPA A;  3FM3 A;  3MR1 A;  1N51 A;  3PKE A;  2Q92 A;  3TAV A;  4FLK A;  2EA4 A;  3MX6 A;  2GZ5 A;  1JAW A;  2G6P A;  4ZWP A;  2GU7 A;  4IDY A;  1W2M A;  2BWV A;  4IKT A;  1XNZ A;  4FLL A;  2OAZ A;  2GG2 A;  2NQ7 A;  2B3H A;  1YJ3 A;  1R58 A;  4U6Z A;  1C23 A;  4IEC A;  4ZWO A;  3FMR A;  2BHB A;  2V3Y A;  2BWS A;  4B28 A;  3L24 A;  2GG9 A;  2EA2 A;  3IU9 A;  4KM3 A;  4PNC A;  3RVA A;  1Y1N A;  2BWX A;  4FO7 A;  3IG4 A;  2BN7 A;  1YVM A;  2MAT A;  5CDL A;  1KQ9 A;  1W7V A;  1BN5 A;  5JFR A;  2BB7 A;  2GG0 A;  1CHM A;  4HXX A;  2EVM A;  2EVO A;  2BWY A;  4IKR A;  4PV4 A;  4U75 A;  4ZWU A;  5JI6 A;  3CB5 A;  1B6A A;  1C21 A;  3D27 A;  1WLR A;  2IW2 A;  2GU6 A;  1C27 A;  5CDE A;  1BOA A;  1A16 A;  2V3Z A;  2B3K A;  3PKB A;  4U71 A;  4U1B A;  2GG7 A;  1C22 A;  2BWU A;  1XGS A;  2ZSG A;  2EVC A;  1YW7 A;  4IKU A;  1YW8 A;  1MAT A;  2P98 A;  2GG3 A;  4IF7 A;  2Q93 A;  3PKC A;  5FCH A;  3CB6 A;  2B3L A;  1QXZ A;  3ROR A;  4U6C A;  5E5B A;  2Q96 A;  4U76 A;  1XGM A;  4U70 A;  2NQ6 A;  3CTZ A;  1WY2 A;  2ADU A;  2GTX A;  1WN1 A;  2BHA A;  4FO8 A;  2BWW A;  2GU4 A;  5CE6 A;  4ZNG A;  5CNX A;  4EGE A;  4RZY A;  4S2R P;  1QZY A;  2HOW A;  4FLJ A;  4U6E A;  1PV9 A;  1QXY A;  2OKN A;  2GA2 A;  5CLS A;  4JUQ A;  5D6F A;  2Q8K A;  1KQ0 A;  4QR8 A;  3Q6D A;  5FCF A;  3IU8 A; 
#chains in the Genus database with same CATH topology
 1R5G A;  1M35 A;  3TB5 A;  4U69 A;  3BIQ A;  4R60 A;  2Q95 A;  1KP0 A;  1R5H A;  1WL6 A;  4RZZ A;  3BIT A;  4IKS A;  3BIP A;  4OOK A;  2GG5 A;  5D6E A;  4FKC A;  2BH3 A;  2GG8 A;  2GU5 A;  5CDV A;  3PKD A;  2BHD A;  1XGN A;  5CIK A;  1QXW A;  3IU7 A;  4S01 A;  4U6W A;  2BHC A;  2GGC A;  1XGO A;  1O0X A;  4MAT A;  3S6B A;  1C24 A;  2DFI A;  3MAT A;  3PKA A;  4U6J A;  2Q94 A;  4FUK A;  4S00 A;  4IU6 A;  2P99 A;  4A6W A;  3FMQ A;  1YW9 A;  2V3X A;  1WL9 A;  4RGZ 1;  4S2T P;  5JHU A;  2GGB A;  4U73 A;  1B59 A;  1WKM A;  2BWT A;  2V6C A;  3L7G A;  4Z7M A;  2P9A A;  1WBQ A;  4FLI A;  4A6V A;  4IPA A;  3FM3 A;  3MR1 A;  1N51 A;  3PKE A;  2Q92 A;  3TAV A;  4FLK A;  2EA4 A;  3MX6 A;  2GZ5 A;  1JAW A;  2G6P A;  4ZWP A;  2GU7 A;  4IDY A;  1W2M A;  2BWV A;  4IKT A;  1XNZ A;  4FLL A;  2OAZ A;  2GG2 A;  2NQ7 A;  2B3H A;  1YJ3 A;  1R58 A;  4U6Z A;  1C23 A;  4IEC A;  4ZWO A;  3FMR A;  2BHB A;  2V3Y A;  2BWS A;  4B28 A;  3L24 A;  2GG9 A;  2EA2 A;  3IU9 A;  4KM3 A;  4PNC A;  3RVA A;  1Y1N A;  2BWX A;  4FO7 A;  3IG4 A;  2BN7 A;  1YVM A;  2MAT A;  5CDL A;  1KQ9 A;  1W7V A;  1BN5 A;  5JFR A;  2BB7 A;  2GG0 A;  1CHM A;  4HXX A;  2EVM A;  2EVO A;  2BWY A;  4IKR A;  4PV4 A;  4U75 A;  4ZWU A;  5JI6 A;  3CB5 A;  1B6A A;  1C21 A;  3D27 A;  1WLR A;  2IW2 A;  2GU6 A;  1C27 A;  5CDE A;  1BOA A;  1A16 A;  2V3Z A;  2B3K A;  3PKB A;  4U71 A;  4U1B A;  2GG7 A;  1C22 A;  2BWU A;  1XGS A;  2ZSG A;  2EVC A;  1YW7 A;  4IKU A;  1YW8 A;  1MAT A;  2P98 A;  2GG3 A;  4IF7 A;  2Q93 A;  3PKC A;  5FCH A;  3CB6 A;  2B3L A;  1QXZ A;  3ROR A;  4U6C A;  5E5B A;  2Q96 A;  4U76 A;  1XGM A;  4U70 A;  2NQ6 A;  3CTZ A;  1WY2 A;  2ADU A;  2GTX A;  1WN1 A;  2BHA A;  4FO8 A;  2BWW A;  2GU4 A;  5CE6 A;  4ZNG A;  5CNX A;  4EGE A;  4RZY A;  4S2R P;  1QZY A;  2HOW A;  4FLJ A;  4U6E A;  1PV9 A;  1QXY A;  2OKN A;  2GA2 A;  5CLS A;  4JUQ A;  5D6F A;  2Q8K A;  1KQ0 A;  4QR8 A;  3Q6D A;  5FCF A;  3IU8 A; 
#chains in the Genus database with same CATH homology
 1R5G A;  1M35 A;  3TB5 A;  4U69 A;  3BIQ A;  4R60 A;  2Q95 A;  1KP0 A;  1R5H A;  1WL6 A;  4RZZ A;  3BIT A;  4IKS A;  3BIP A;  4OOK A;  2GG5 A;  5D6E A;  4FKC A;  2BH3 A;  2GG8 A;  2GU5 A;  5CDV A;  3PKD A;  2BHD A;  1XGN A;  5CIK A;  1QXW A;  3IU7 A;  4S01 A;  4U6W A;  2BHC A;  2GGC A;  1XGO A;  1O0X A;  4MAT A;  3S6B A;  1C24 A;  2DFI A;  3MAT A;  3PKA A;  4U6J A;  2Q94 A;  4FUK A;  4S00 A;  4IU6 A;  2P99 A;  4A6W A;  3FMQ A;  1YW9 A;  2V3X A;  1WL9 A;  4RGZ 1;  4S2T P;  5JHU A;  2GGB A;  4U73 A;  1B59 A;  1WKM A;  2BWT A;  2V6C A;  3L7G A;  4Z7M A;  2P9A A;  1WBQ A;  4FLI A;  4A6V A;  4IPA A;  3FM3 A;  3MR1 A;  1N51 A;  3PKE A;  2Q92 A;  3TAV A;  4FLK A;  2EA4 A;  3MX6 A;  2GZ5 A;  1JAW A;  2G6P A;  4ZWP A;  2GU7 A;  4IDY A;  1W2M A;  2BWV A;  4IKT A;  1XNZ A;  4FLL A;  2OAZ A;  2GG2 A;  2NQ7 A;  2B3H A;  1YJ3 A;  1R58 A;  4U6Z A;  1C23 A;  4IEC A;  4ZWO A;  3FMR A;  2BHB A;  2V3Y A;  2BWS A;  4B28 A;  3L24 A;  2GG9 A;  2EA2 A;  3IU9 A;  4KM3 A;  4PNC A;  3RVA A;  1Y1N A;  2BWX A;  4FO7 A;  3IG4 A;  2BN7 A;  1YVM A;  2MAT A;  5CDL A;  1KQ9 A;  1W7V A;  1BN5 A;  5JFR A;  2BB7 A;  2GG0 A;  1CHM A;  4HXX A;  2EVM A;  2EVO A;  2BWY A;  4IKR A;  4PV4 A;  4U75 A;  4ZWU A;  5JI6 A;  3CB5 A;  1B6A A;  1C21 A;  3D27 A;  1WLR A;  2IW2 A;  2GU6 A;  1C27 A;  5CDE A;  1BOA A;  1A16 A;  2V3Z A;  2B3K A;  3PKB A;  4U71 A;  4U1B A;  2GG7 A;  1C22 A;  2BWU A;  1XGS A;  2ZSG A;  2EVC A;  1YW7 A;  4IKU A;  1YW8 A;  1MAT A;  2P98 A;  2GG3 A;  4IF7 A;  2Q93 A;  3PKC A;  5FCH A;  3CB6 A;  2B3L A;  1QXZ A;  3ROR A;  4U6C A;  5E5B A;  2Q96 A;  4U76 A;  1XGM A;  4U70 A;  2NQ6 A;  3CTZ A;  1WY2 A;  2ADU A;  2GTX A;  1WN1 A;  2BHA A;  4FO8 A;  2BWW A;  2GU4 A;  5CE6 A;  4ZNG A;  5CNX A;  4EGE A;  4RZY A;  4S2R P;  1QZY A;  2HOW A;  4FLJ A;  4U6E A;  1PV9 A;  1QXY A;  2OKN A;  2GA2 A;  5CLS A;  4JUQ A;  5D6F A;  2Q8K A;  1KQ0 A;  4QR8 A;  3Q6D A;  5FCF A;  3IU8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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