2HB1A

Crystal structure of ptp1b with monocyclic thiophene inhibitor
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
297
structure length
297
Chain Sequence
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48.
pubmed doi rcsb
molecule keywords Tyrosine-protein phosphatase non-receptor type 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 109
structure length 297
sequence length 297
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2006-06-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00102 Y_phosphatase Protein-tyrosine phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.190.10 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Protein tyrosine phosphatase superfamily 2hb1A00
2VEXA 3EAXA 4YAAA 3MMJA 3PS5A 2NT2A 4B04A 1G1FA 4JMKA 2E0TA 2H4GA 2P4DA 3QCMA 4ICZA 1X24A 4KYRA 2QDMA 3F99A 3D1QA 4WU3A 1T48A 1C83A 3QKPA 5KA2A 1YTWA 2A3KA 4ZN5A 1PH0A 4GE2A 4RHGA 1NWLA 1BZJA 4RH5A 5LXQB 1Q6PA 3S4OA 1G1GA 3QCDA 2HC1A 1PXHA 1ZZWA 2C7SA 1OEVA 2HVLA 1NZ7A 3O4UA 4NNDA 2Y2FA 4D3RA 1GWZA 3AWEA 4HRFA 3GXGA 4HJQA 5BX1A 1PTUA 1Q6JA 4AZ1A 5M43A 3NMEA 5AWXA 2AHSA 4GFUA 3BLTA 1WCHA 2CMAA 1XM2A 2VEUA 3D9CA 3ZM1A 2PT0A 4I8NA 4S0GA 4QAHA 2YDUA 2GP0A 4NWFA 1C87A 1QXKA 1KAVA 3F9BA 4JMJA 4R0TA 2B49A 4TVVA 1I57A 1WRMA 2NTAA 5J8RA 2F46A 1VHRA 3ZM3A 2F6VA 5KA0A 4RDDA 4Y2EA 2VEVA 1YGUA 3EB1A 4PYHA 2CNHA 2BGDA 3RGOA 3ZV2A 2J17A 4NWGA 4PVGA 4DGPA 3I7ZA 2H02A 4RI4A 5BUGA 4R30A 1U26A 2OC3A 1YN9A 2AZRA 4GWFA 2C46A 3QCLA 2HNQA 5K9WA 2GWOA 2FH7A 2I4EA 2QCTA 4GE5A 2QEPA 3EU0A 4DGXA 2Y96A 3ZMQA 4JBCA 2I4HA 2G59A 2IMGA 1NO6A 4QUNA 4YR8B 4HJPA 1PTVA 5K23A 4MBBA 2ESBA 2ZN7A 3V0IA 1Q6NA 1Q6TA 4NX8A 2I4GA 3F81A 4GRYA 4BJOA 4NYHA 1XXPA 4QBWA 3S3HA 1PA9A 3D44A 3V0HA 2HNPA 1YWFA 5I6VA 4OHEA 2I6OA 4OHIA 4BPCA 1BZCA 2H4VA 4ZI4A 1OHEA 3OLRA 1ONYA 2DXPA 2F6ZA 2PBNA 4RH9A 1V3AA 2VEYA 3D1OA 2R0BA 5KABA 5IBSA 2CNIA 2QBPA 2OZ5A 3ZMPA 1I9TA 1Q1MA 2I5XA 4D3PA 2B4PA 1JLNA 1U24A 1YPTA 3OMHA 2FJNA 3O3LA 2I6IA 1T4JA 4Z6BA 2I75A 5KA7A 2NT7A 3N0AA 1G4US 3BLUA 1OEMX 5K22A 1NL9A 2JJDA 2MBCA 4QAPA 2F6FA 5KADA 3A5KA 2FJMA 3RO1A 1C86A 4GE6A 5KA1A 3QCCA 1FPRA 2B4UA 3O4SA 1PTTA 1G7FA 3M4UA 4ZRTA 4WTYA 3V0DA 1XBOA 3I36A 4RI5A 2BGEA 2F71A 2P6XA 1ECVA 2CM8A 5KA4A 1G4WR 3GXHA 2G6ZA 2I6PA 2PQ5A 3SR9A 2BIJA 1YTSA 1ZCLA 3ZM0A 4ERCA 2HB1A 3S4EA 1LYVA 3F41A 2HC2A 2ZMMA 3AWFA 2HXPA 4H1OA 1RPMA 4J51A 5BZZA 3I80A 2OOQA 4Y14A 1KAKA 2QBQA 1I9SA 3BRHA 3ZM2A 1MKPA 2I6JA 1NNYA 2HCMA 2I6MA 1A5YA 5KA9A 2H03A 2SHPA 3A5JA 4R0SA 1XXVA 3U96A 3S3KA 1L8GA 1NWEA 4QBEA 4KYQA 3V0FA 2CNGA 1M3GA 3RZ2A 3QCNA 2A8BA 2QDCA 2I42A 3QCFA 2H4KA 1QZ0A 3O5XA 3MOZA 4WU2A 3QCHA 3CWEA 1J4XA 1C85A 2Q05A 2I3UA 4GS0A 1L8KA 4OHDA 3QCEA 1P15A 2OUDA 3LJ8A 2B07A 4JNBA 3BM8A 1EEOA 3O4TA 2WGPA 1ZC0A 1AAXA 3V0JA 2CFVA 1C88A 2I3RA 2NV5A 2QDPA 2B4SA 2PI7A 5K24A 2NLKA 4OHHA 2F6TA 4WOHA 1PTYA 1OEOX 1JF7A 1PYNA 3F9AA 3QCKA 4H34A 1G1HA 2B4OA 3H2XA 1FPZA 1RXDA 4KI9A 3B7OA 5KAAA 2M3VA 2F6WA 2CMBA 1G7GA 4RKKA 1ZCKA 2J16B 3AWGA 1OETA 1Q6MA 1FQ1A 4OHLA 1BZHA 2BZLA 2I1YA 1LQFA 1OHCA 2H04A 2BV5A 2PSZA 2GJTA 2CNFA 2NZ6A 1PA1A 1WAXA 2B3OA 1YZ4A 1ONZA 5IBMA 2CJZA 2CM2A 2CMCA 2RF6A 4GFVA 3V0GA 1XRIA 2CNEA 3SMEA 5BZXA 2F70A 2QBSA 1GFYA 1EENA 3QKQA 2HY3A 3S3FA 1OESA 5KACA 3QCBA 1YGRA 1R6HA 5K25A 5KA8A 2CM3A 3EZZA 4IKCA 2QBRA 5GTJA 5EHPA 3V0EA 3D42A 3D1HA 3QCGA 1T49A 3QCIA 3QCJA 1SUGA 1U25A 5HDEA 2Q47A 1C84A 5K9VA 3RGQA 3MOWA 1YTNA 1OEUA 2J16A 4D3QA 1OHDA 1YFOA 5KA3A 4QUMA 5MMZB 1LARA 1Q6SA 3S3EA 5EHRA 2F6YA 2VEWA 2PA5A 1D5RA 3EMUA 3CM3A 2CM7A 2QCJA 4GRZA
chains in the Genus database with same CATH superfamily
2VEXA 3EAXA 4YAAA 3MMJA 3PS5A 2NT2A 2JFGA 1G1FA 4B04A 4JMKA 2E0TA 2H4GA 2P4DA 3QCMA 4ICZA 1X24A 4KYRA 2QDMA 3F99A 3D1QA 4WU3A 1T48A 1C83A 3QKPA 1E0DA 5KA2A 3NRSA 4C12A 1YTWA 2A3KA 2WTZA 4ZN5A 1PH0A 4GE2A 4RHGA 1NWLA 1BZJA 4RH5A 5LXQB 1Q6PA 2X5OA 3S4OA 1G1GA 3QCDA 4C13A 1JBVA 2HC1A 1PXHA 1ZZWA 2C7SA 1OEVA 2HVLA 1NZ7A 3O4UA 4NNDA 2Y2FA 4D3RA 1GWZA 3AWEA 4HRFA 3GXGA 4HJQA 5BX1A 1PTUA 1Q6JA 4AZ1A 5M43A 3NMEA 5AWXA 2AHSA 4GFUA 3BLTA 1WCHA 2CMAA 1XM2A 2VEUA 3D9CA 3ZM1A 2PT0A 1J6UA 4I8NA 4S0GA 4QAHA 2YDUA 2GP0A 4NWFA 1C87A 1QXKA 1KAVA 3F9BA 4JMJA 4R0TA 2B49A 4TVVA 1I57A 1WRMA 2NTAA 5J8RA 2F46A 1VHRA 3ZM3A 1GQYA 2F6VA 5KA0A 4RDDA 4Y2EA 2GC6A 2VEVA 1YGUA 2Y1OA 3EB1A 4PYHA 2CNHA 2BGDA 3RGOA 2UUPA 3ZV2A 2GCBA 2J17A 4NWGA 4PVGA 4DGPA 2Y67A 3I7ZA 2H02A 4RI4A 5BUGA 4R30A 1U26A 2OC3A 1YN9A 2AZRA 4GWFA 2JFFA 2C46A 3QCLA 2HNQA 2XJAA 5K9WA 2GWOA 2FH7A 2I4EA 2QCTA 2WJPA 4GE5A 2QEPA 3EU0A 4DGXA 2Y96A 3ZMQA 4JBCA 2I4HA 2G59A 2IMGA 1NO6A 4QUNA 4YR8B 4HJPA 1PTVA 5K23A 4MBBA 2ESBA 2ZN7A 3V0IA 1Q6NA 1Q6TA 4ZIYA 4NX8A 2I4GA 3F81A 4GRYA 4BJOA 4NYHA 3LK7A 1XXPA 2VOSA 4QBWA 3HN7A 3S3HA 1PA9A 2Y66A 3D44A 3V0HA 2HNPA 1YWFA 5I6VA 4OHEA 2I6OA 4OHIA 4BPCA 1BZCA 3UAGA 2H4VA 4ZI4A 1OHEA 4HV4A 3OLRA 1ONYA 2DXPA 2F6ZA 2PBNA 4RH9A 1V3AA 2VEYA 3D1OA 2R0BA 5KABA 5IBSA 2CNIA 2QBPA 2OZ5A 2XPCA 1W78A 2AM2A 3ZMPA 1I9TA 1Q1MA 2I5XA 4D3PA 2B4PA 1JLNA 1U24A 1YPTA 3OMHA 2FJNA 3O3LA 2I6IA 1T4JA 4Z6BA 2I75A 2UUOA 5KA7A 2NT7A 3N0AA 1G4US 3BLUA 3ZL8A 1OEMX 5K22A 1NL9A 3MVNA 2JJDA 2MBCA 4QAPA 2F6FA 5KADA 3A5KA 2FJMA 1W7KA 3RO1A 1C86A 1GG4A 4GE6A 5KA1A 3QCCA 1FPRA 2B4UA 3O4SA 1PTTA 1G7FA 3M4UA 4QF5A 4UAGA 4ZRTA 4WTYA 3QCZA 1XBOA 3I36A 3V0DA 4CVMA 4RI5A 5A5FA 2BGEA 2F71A 2P6XA 1ECVA 2CM8A 1UAGA 1E8CA 1G4WR 5KA4A 3GXHA 2G6ZA 2I6PA 2PQ5A 3SR9A 2BIJA 1YTSA 1ZCLA 3ZM0A 4ERCA 2HB1A 4QDIA 2GCAA 1LYVA 3F41A 3S4EA 2HC2A 2ZMMA 1JBWA 3AWFA 2HXPA 4H1OA 1RPMA 4J51A 5BZZA 3I80A 2OOQA 4Y14A 1KAKA 2F00A 2QBQA 1I9SA 3BRHA 2AM1A 3ZM2A 1MKPA 2I6JA 1NNYA 2HCMA 2I6MA 1A5YA 5KA9A 2H03A 2SHPA 3A5JA 4R0SA 1XXVA 3U96A 3S3KA 1L8GA 1NWEA 4QBEA 4KYQA 3V0FA 2CNGA 1M3GA 3RZ2A 3PYZA 3QCNA 2A8BA 2QDCA 2I42A 3QCFA 2H4KA 1QZ0A 3O5XA 1EEHA 3MOZA 4WU2A 3QCHA 2GC5A 3CWEA 1J4XA 1C85A 2Q05A 2I3UA 4GS0A 1L8KA 4OHDA 3QCEA 1P15A 2OUDA 3LJ8A 2B07A 4JNBA 3BM8A 1EEOA 3O4TA 2WGPA 1ZC0A 1AAXA 3V0JA 2CFVA 1C88A 2I3RA 2NV5A 2QDPA 2B4SA 2PI7A 5K24A 1P3DA 3N2AA 2NLKA 4CVKA 4OHHA 2F6TA 4WOHA 1PTYA 1OEOX 4CVLA 1JF7A 1PYNA 3F9AA 3QCKA 4H34A 2VTDA 1G1HA 2B4OA 3H2XA 1FPZA 1RXDA 4KI9A 3B7OA 5KAAA 2M3VA 2F6WA 2CMBA 1G7GA 4RKKA 1ZCKA 2J16B 5A5EA 3AWGA 1OETA 1Q6MA 2Y68A 1FQ1A 4OHLA 1BZHA 2BZLA 2I1YA 3ZM6A 1GQQA 1LQFA 1OHCA 2H04A 2BV5A 1P31A 2PSZA 2GJTA 2CNFA 2NZ6A 1PA1A 1WAXA 2B3OA 1FGSA 1YZ4A 1ONZA 5IBMA 2CJZA 2CM2A 2CMCA 2RF6A 3ZM5A 4GFVA 3V0GA 1XRIA 2CNEA 3SMEA 5BZXA 2F70A 2QBSA 1GFYA 1EENA 3QKQA 2HY3A 3S3FA 1OESA 5KACA 2VTEA 1YGRA 3QCBA 1R6HA 5K25A 2UAGA 5KA8A 2CM3A 3EZZA 4IKCA 4BUBA 2QBRA 5GTJA 5EHPA 3V0EA 3D42A 2JFHA 3D1HA 3QCGA 1O5ZA 1T49A 3QCIA 3QCJA 1SUGA 1U25A 5HDEA 2Q47A 1C84A 5K9VA 3RGQA 3MOWA 1YTNA 1OEUA 2J16A 4D3QA 1OHDA 1YFOA 5KA3A 4QUMA 5MMZB 1LARA 1Q6SA 3S3EA 5EHRA 2F6YA 2VEWA 2PA5A 1D5RA 3EMUA 3CM3A 2CM7A 2VORA 2QCJA 4BUCA 4GRZA
chains in the Genus database with same CATH topology
2VEXA 3EAXA 4YAAA 3MMJA 3PS5A 2NT2A 4B04A 1G1FA 4JMKA 2E0TA 2H4GA 2P4DA 3QCMA 4ICZA 1X24A 4KYRA 2QDMA 3F99A 3D1QA 4WU3A 1T48A 1C83A 3QKPA 5KA2A 1YTWA 2A3KA 4ZN5A 1PH0A 4GE2A 4RHGA 1NWLA 1BZJA 4RH5A 5LXQB 1Q6PA 3S4OA 1G1GA 3QCDA 2HC1A 1PXHA 1ZZWA 2C7SA 1OEVA 2HVLA 1NZ7A 3O4UA 4NNDA 2Y2FA 4D3RA 1GWZA 3AWEA 4HRFA 3GXGA 4HJQA 5BX1A 1PTUA 1Q6JA 4AZ1A 5M43A 3NMEA 5AWXA 2AHSA 4GFUA 3BLTA 1WCHA 2CMAA 1XM2A 2VEUA 3D9CA 3ZM1A 2PT0A 4I8NA 4S0GA 4QAHA 2YDUA 2GP0A 4NWFA 1C87A 1QXKA 1KAVA 3F9BA 4JMJA 4R0TA 2B49A 4TVVA 1I57A 1WRMA 2NTAA 5J8RA 2F46A 1VHRA 3ZM3A 2F6VA 5KA0A 4RDDA 4Y2EA 2VEVA 1YGUA 3EB1A 4PYHA 2CNHA 2BGDA 3RGOA 3ZV2A 2J17A 4NWGA 4PVGA 4DGPA 3I7ZA 2H02A 4RI4A 5BUGA 4R30A 1U26A 2OC3A 1YN9A 2AZRA 4GWFA 2C46A 3QCLA 2HNQA 5K9WA 2GWOA 2FH7A 2I4EA 2QCTA 4GE5A 2QEPA 3EU0A 4DGXA 2Y96A 3ZMQA 4JBCA 2I4HA 2G59A 2IMGA 1NO6A 4QUNA 4YR8B 4HJPA 1PTVA 5K23A 4MBBA 2ESBA 2ZN7A 3V0IA 1Q6NA 1Q6TA 4NX8A 2I4GA 3F81A 4GRYA 4BJOA 4NYHA 1XXPA 4QBWA 3S3HA 1PA9A 3D44A 3V0HA 2HNPA 1YWFA 5I6VA 4OHEA 2I6OA 4OHIA 4BPCA 1BZCA 2H4VA 4ZI4A 1OHEA 3OLRA 1ONYA 2DXPA 2F6ZA 2PBNA 4RH9A 1V3AA 2VEYA 3D1OA 2R0BA 5KABA 5IBSA 2CNIA 2QBPA 2OZ5A 3ZMPA 1I9TA 1Q1MA 2I5XA 4D3PA 2B4PA 1JLNA 1U24A 1YPTA 3OMHA 2FJNA 3O3LA 2I6IA 1T4JA 4Z6BA 2I75A 5KA7A 2NT7A 3N0AA 1G4US 3BLUA 1OEMX 5K22A 1NL9A 2JJDA 2MBCA 4QAPA 2F6FA 5KADA 3A5KA 2FJMA 3RO1A 1C86A 4GE6A 5KA1A 3QCCA 1FPRA 2B4UA 3O4SA 1PTTA 1G7FA 3M4UA 4ZRTA 4WTYA 3V0DA 1XBOA 3I36A 4RI5A 2BGEA 2F71A 2P6XA 1ECVA 2CM8A 5KA4A 1G4WR 3GXHA 2G6ZA 2I6PA 2PQ5A 3SR9A 2BIJA 1YTSA 1ZCLA 3ZM0A 4ERCA 2HB1A 3S4EA 1LYVA 3F41A 2HC2A 2ZMMA 3AWFA 2HXPA 4H1OA 1RPMA 4J51A 5BZZA 3I80A 2OOQA 4Y14A 1KAKA 2QBQA 1I9SA 3BRHA 3ZM2A 1MKPA 2I6JA 1NNYA 2HCMA 2I6MA 1A5YA 5KA9A 2H03A 2SHPA 3A5JA 4R0SA 1XXVA 3U96A 3S3KA 1L8GA 1NWEA 4QBEA 4KYQA 3V0FA 2CNGA 1M3GA 3RZ2A 3QCNA 2A8BA 2QDCA 2I42A 3QCFA 2H4KA 1QZ0A 3O5XA 3MOZA 4WU2A 3QCHA 3CWEA 1J4XA 1C85A 2Q05A 2I3UA 4GS0A 1L8KA 4OHDA 3QCEA 1P15A 2OUDA 3LJ8A 2B07A 4JNBA 3BM8A 1EEOA 3O4TA 2WGPA 1ZC0A 1AAXA 3V0JA 2CFVA 1C88A 2I3RA 2NV5A 2QDPA 2B4SA 2PI7A 5K24A 2NLKA 4OHHA 2F6TA 4WOHA 1PTYA 1OEOX 1JF7A 1PYNA 3F9AA 3QCKA 4H34A 1G1HA 2B4OA 3H2XA 1FPZA 1RXDA 4KI9A 3B7OA 5KAAA 2M3VA 2F6WA 2CMBA 1G7GA 4RKKA 1ZCKA 2J16B 3AWGA 1OETA 1Q6MA 1FQ1A 4OHLA 1BZHA 2BZLA 2I1YA 1LQFA 1OHCA 2H04A 2BV5A 2PSZA 2GJTA 2CNFA 2NZ6A 1PA1A 1WAXA 2B3OA 1YZ4A 1ONZA 5IBMA 2CJZA 2CM2A 2CMCA 2RF6A 4GFVA 3V0GA 1XRIA 2CNEA 3SMEA 5BZXA 2F70A 2QBSA 1GFYA 1EENA 3QKQA 2HY3A 3S3FA 1OESA 5KACA 3QCBA 1YGRA 1R6HA 5K25A 5KA8A 2CM3A 3EZZA 4IKCA 2QBRA 5GTJA 5EHPA 3V0EA 3D42A 3D1HA 3QCGA 1T49A 3QCIA 3QCJA 1SUGA 1U25A 5HDEA 2Q47A 1C84A 5K9VA 3RGQA 3MOWA 1YTNA 1OEUA 2J16A 4D3QA 1OHDA 1YFOA 5KA3A 4QUMA 5MMZB 1LARA 1Q6SA 3S3EA 5EHRA 2F6YA 2VEWA 2PA5A 1D5RA 3EMUA 3CM3A 2CM7A 2QCJA 4GRZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VEX A;  3EAX A;  4YAA A;  3MMJ A;  3PS5 A;  2NT2 A;  4B04 A;  1G1F A;  4JMK A;  2E0T A;  2H4G A;  2P4D A;  3QCM A;  4ICZ A;  1X24 A;  4KYR A;  2QDM A;  3F99 A;  3D1Q A;  4WU3 A;  1T48 A;  1C83 A;  3QKP A;  5KA2 A;  1YTW A;  2A3K A;  4ZN5 A;  1PH0 A;  4GE2 A;  4RHG A;  1NWL A;  1BZJ A;  4RH5 A;  5LXQ B;  1Q6P A;  3S4O A;  1G1G A;  3QCD A;  2HC1 A;  1PXH A;  1ZZW A;  2C7S A;  1OEV A;  2HVL A;  1NZ7 A;  3O4U A;  4NND A;  2Y2F A;  4D3R A;  1GWZ A;  3AWE A;  4HRF A;  3GXG A;  4HJQ A;  5BX1 A;  1PTU A;  1Q6J A;  4AZ1 A;  5M43 A;  3NME A;  5AWX A;  2AHS A;  4GFU A;  3BLT A;  1WCH A;  2CMA A;  1XM2 A;  2VEU A;  3D9C A;  3ZM1 A;  2PT0 A;  4I8N A;  4S0G A;  4QAH A;  2YDU A;  2GP0 A;  4NWF A;  1C87 A;  1QXK A;  1KAV A;  3F9B A;  4JMJ A;  4R0T A;  2B49 A;  4TVV A;  1I57 A;  1WRM A;  2NTA A;  5J8R A;  2F46 A;  1VHR A;  3ZM3 A;  2F6V A;  5KA0 A;  4RDD A;  4Y2E A;  2VEV A;  1YGU A;  3EB1 A;  4PYH A;  2CNH A;  2BGD A;  3RGO A;  3ZV2 A;  2J17 A;  4NWG A;  4PVG A;  4DGP A;  3I7Z A;  2H02 A;  4RI4 A;  5BUG A;  4R30 A;  1U26 A;  2OC3 A;  1YN9 A;  2AZR A;  4GWF A;  2C46 A;  3QCL A;  2HNQ A;  5K9W A;  2GWO A;  2FH7 A;  2I4E A;  2QCT A;  4GE5 A;  2QEP A;  3EU0 A;  4DGX A;  2Y96 A;  3ZMQ A;  4JBC A;  2I4H A;  2G59 A;  2IMG A;  1NO6 A;  4QUN A;  4YR8 B;  4HJP A;  1PTV A;  5K23 A;  4MBB A;  2ESB A;  2ZN7 A;  3V0I A;  1Q6N A;  1Q6T A;  4NX8 A;  2I4G A;  3F81 A;  4GRY A;  4BJO A;  4NYH A;  1XXP A;  4QBW A;  3S3H A;  1PA9 A;  3D44 A;  3V0H A;  2HNP A;  1YWF A;  5I6V A;  4OHE A;  2I6O A;  4OHI A;  4BPC A;  1BZC A;  2H4V A;  4ZI4 A;  1OHE A;  3OLR A;  1ONY A;  2DXP A;  2F6Z A;  2PBN A;  4RH9 A;  1V3A A;  2VEY A;  3D1O A;  2R0B A;  5KAB A;  5IBS A;  2CNI A;  2QBP A;  2OZ5 A;  3ZMP A;  1I9T A;  1Q1M A;  2I5X A;  4D3P A;  2B4P A;  1JLN A;  1U24 A;  1YPT A;  3OMH A;  2FJN A;  3O3L A;  2I6I A;  1T4J A;  4Z6B A;  2I75 A;  5KA7 A;  2NT7 A;  3N0A A;  1G4U S;  3BLU A;  1OEM X;  5K22 A;  1NL9 A;  2JJD A;  2MBC A;  4QAP A;  2F6F A;  5KAD A;  3A5K A;  2FJM A;  3RO1 A;  1C86 A;  4GE6 A;  5KA1 A;  3QCC A;  1FPR A;  2B4U A;  3O4S A;  1PTT A;  1G7F A;  3M4U A;  4ZRT A;  4WTY A;  3V0D A;  1XBO A;  3I36 A;  4RI5 A;  2BGE A;  2F71 A;  2P6X A;  1ECV A;  2CM8 A;  5KA4 A;  1G4W R;  3GXH A;  2G6Z A;  2I6P A;  2PQ5 A;  3SR9 A;  2BIJ A;  1YTS A;  1ZCL A;  3ZM0 A;  4ERC A;  2HB1 A;  3S4E A;  1LYV A;  3F41 A;  2HC2 A;  2ZMM A;  3AWF A;  2HXP A;  4H1O A;  1RPM A;  4J51 A;  5BZZ A;  3I80 A;  2OOQ A;  4Y14 A;  1KAK A;  2QBQ A;  1I9S A;  3BRH A;  3ZM2 A;  1MKP A;  2I6J A;  1NNY A;  2HCM A;  2I6M A;  1A5Y A;  5KA9 A;  2H03 A;  2SHP A;  3A5J A;  4R0S A;  1XXV A;  3U96 A;  3S3K A;  1L8G A;  1NWE A;  4QBE A;  4KYQ A;  3V0F A;  2CNG A;  1M3G A;  3RZ2 A;  3QCN A;  2A8B A;  2QDC A;  2I42 A;  3QCF A;  2H4K A;  1QZ0 A;  3O5X A;  3MOZ A;  4WU2 A;  3QCH A;  3CWE A;  1J4X A;  1C85 A;  2Q05 A;  2I3U A;  4GS0 A;  1L8K A;  4OHD A;  3QCE A;  1P15 A;  2OUD A;  3LJ8 A;  2B07 A;  4JNB A;  3BM8 A;  1EEO A;  3O4T A;  2WGP A;  1ZC0 A;  1AAX A;  3V0J A;  2CFV A;  1C88 A;  2I3R A;  2NV5 A;  2QDP A;  2B4S A;  2PI7 A;  5K24 A;  2NLK A;  4OHH A;  2F6T A;  4WOH A;  1PTY A;  1OEO X;  1JF7 A;  1PYN A;  3F9A A;  3QCK A;  4H34 A;  1G1H A;  2B4O A;  3H2X A;  1FPZ A;  1RXD A;  4KI9 A;  3B7O A;  5KAA A;  2M3V A;  2F6W A;  2CMB A;  1G7G A;  4RKK A;  1ZCK A;  2J16 B;  3AWG A;  1OET A;  1Q6M A;  1FQ1 A;  4OHL A;  1BZH A;  2BZL A;  2I1Y A;  1LQF A;  1OHC A;  2H04 A;  2BV5 A;  2PSZ A;  2GJT A;  2CNF A;  2NZ6 A;  1PA1 A;  1WAX A;  2B3O A;  1YZ4 A;  1ONZ A;  5IBM A;  2CJZ A;  2CM2 A;  2CMC A;  2RF6 A;  4GFV A;  3V0G A;  1XRI A;  2CNE A;  3SME A;  5BZX A;  2F70 A;  2QBS A;  1GFY A;  1EEN A;  3QKQ A;  2HY3 A;  3S3F A;  1OES A;  5KAC A;  3QCB A;  1YGR A;  1R6H A;  5K25 A;  5KA8 A;  2CM3 A;  3EZZ A;  4IKC A;  2QBR A;  5GTJ A;  5EHP A;  3V0E A;  3D42 A;  3D1H A;  3QCG A;  1T49 A;  3QCI A;  3QCJ A;  1SUG A;  1U25 A;  5HDE A;  2Q47 A;  1C84 A;  5K9V A;  3RGQ A;  3MOW A;  1YTN A;  1OEU A;  2J16 A;  4D3Q A;  1OHD A;  1YFO A;  5KA3 A;  4QUM A;  5MMZ B;  1LAR A;  1Q6S A;  3S3E A;  5EHR A;  2F6Y A;  2VEW A;  2PA5 A;  1D5R A;  3EMU A;  3CM3 A;  2CM7 A;  2QCJ A;  4GRZ A; 
#chains in the Genus database with same CATH topology
 2VEX A;  3EAX A;  4YAA A;  3MMJ A;  3PS5 A;  2NT2 A;  2JFG A;  1G1F A;  4B04 A;  4JMK A;  2E0T A;  2H4G A;  2P4D A;  3QCM A;  4ICZ A;  1X24 A;  4KYR A;  2QDM A;  3F99 A;  3D1Q A;  4WU3 A;  1T48 A;  1C83 A;  3QKP A;  1E0D A;  5KA2 A;  3NRS A;  4C12 A;  1YTW A;  2A3K A;  2WTZ A;  4ZN5 A;  1PH0 A;  4GE2 A;  4RHG A;  1NWL A;  1BZJ A;  4RH5 A;  5LXQ B;  1Q6P A;  2X5O A;  3S4O A;  1G1G A;  3QCD A;  4C13 A;  1JBV A;  2HC1 A;  1PXH A;  1ZZW A;  2C7S A;  1OEV A;  2HVL A;  1NZ7 A;  3O4U A;  4NND A;  2Y2F A;  4D3R A;  1GWZ A;  3AWE A;  4HRF A;  3GXG A;  4HJQ A;  5BX1 A;  1PTU A;  1Q6J A;  4AZ1 A;  5M43 A;  3NME A;  5AWX A;  2AHS A;  4GFU A;  3BLT A;  1WCH A;  2CMA A;  1XM2 A;  2VEU A;  3D9C A;  3ZM1 A;  2PT0 A;  1J6U A;  4I8N A;  4S0G A;  4QAH A;  2YDU A;  2GP0 A;  4NWF A;  1C87 A;  1QXK A;  1KAV A;  3F9B A;  4JMJ A;  4R0T A;  2B49 A;  4TVV A;  1I57 A;  1WRM A;  2NTA A;  5J8R A;  2F46 A;  1VHR A;  3ZM3 A;  1GQY A;  2F6V A;  5KA0 A;  4RDD A;  4Y2E A;  2GC6 A;  2VEV A;  1YGU A;  2Y1O A;  3EB1 A;  4PYH A;  2CNH A;  2BGD A;  3RGO A;  2UUP A;  3ZV2 A;  2GCB A;  2J17 A;  4NWG A;  4PVG A;  4DGP A;  2Y67 A;  3I7Z A;  2H02 A;  4RI4 A;  5BUG A;  4R30 A;  1U26 A;  2OC3 A;  1YN9 A;  2AZR A;  4GWF A;  2JFF A;  2C46 A;  3QCL A;  2HNQ A;  2XJA A;  5K9W A;  2GWO A;  2FH7 A;  2I4E A;  2QCT A;  2WJP A;  4GE5 A;  2QEP A;  3EU0 A;  4DGX A;  2Y96 A;  3ZMQ A;  4JBC A;  2I4H A;  2G59 A;  2IMG A;  1NO6 A;  4QUN A;  4YR8 B;  4HJP A;  1PTV A;  5K23 A;  4MBB A;  2ESB A;  2ZN7 A;  3V0I A;  1Q6N A;  1Q6T A;  4ZIY A;  4NX8 A;  2I4G A;  3F81 A;  4GRY A;  4BJO A;  4NYH A;  3LK7 A;  1XXP A;  2VOS A;  4QBW A;  3HN7 A;  3S3H A;  1PA9 A;  2Y66 A;  3D44 A;  3V0H A;  2HNP A;  1YWF A;  5I6V A;  4OHE A;  2I6O A;  4OHI A;  4BPC A;  1BZC A;  3UAG A;  2H4V A;  4ZI4 A;  1OHE A;  4HV4 A;  3OLR A;  1ONY A;  2DXP A;  2F6Z A;  2PBN A;  4RH9 A;  1V3A A;  2VEY A;  3D1O A;  2R0B A;  5KAB A;  5IBS A;  2CNI A;  2QBP A;  2OZ5 A;  2XPC A;  1W78 A;  2AM2 A;  3ZMP A;  1I9T A;  1Q1M A;  2I5X A;  4D3P A;  2B4P A;  1JLN A;  1U24 A;  1YPT A;  3OMH A;  2FJN A;  3O3L A;  2I6I A;  1T4J A;  4Z6B A;  2I75 A;  2UUO A;  5KA7 A;  2NT7 A;  3N0A A;  1G4U S;  3BLU A;  3ZL8 A;  1OEM X;  5K22 A;  1NL9 A;  3MVN A;  2JJD A;  2MBC A;  4QAP A;  2F6F A;  5KAD A;  3A5K A;  2FJM A;  1W7K A;  3RO1 A;  1C86 A;  1GG4 A;  4GE6 A;  5KA1 A;  3QCC A;  1FPR A;  2B4U A;  3O4S A;  1PTT A;  1G7F A;  3M4U A;  4QF5 A;  4UAG A;  4ZRT A;  4WTY A;  3QCZ A;  1XBO A;  3I36 A;  3V0D A;  4CVM A;  4RI5 A;  5A5F A;  2BGE A;  2F71 A;  2P6X A;  1ECV A;  2CM8 A;  1UAG A;  1E8C A;  1G4W R;  5KA4 A;  3GXH A;  2G6Z A;  2I6P A;  2PQ5 A;  3SR9 A;  2BIJ A;  1YTS A;  1ZCL A;  3ZM0 A;  4ERC A;  2HB1 A;  4QDI A;  2GCA A;  1LYV A;  3F41 A;  3S4E A;  2HC2 A;  2ZMM A;  1JBW A;  3AWF A;  2HXP A;  4H1O A;  1RPM A;  4J51 A;  5BZZ A;  3I80 A;  2OOQ A;  4Y14 A;  1KAK A;  2F00 A;  2QBQ A;  1I9S A;  3BRH A;  2AM1 A;  3ZM2 A;  1MKP A;  2I6J A;  1NNY A;  2HCM A;  2I6M A;  1A5Y A;  5KA9 A;  2H03 A;  2SHP A;  3A5J A;  4R0S A;  1XXV A;  3U96 A;  3S3K A;  1L8G A;  1NWE A;  4QBE A;  4KYQ A;  3V0F A;  2CNG A;  1M3G A;  3RZ2 A;  3PYZ A;  3QCN A;  2A8B A;  2QDC A;  2I42 A;  3QCF A;  2H4K A;  1QZ0 A;  3O5X A;  1EEH A;  3MOZ A;  4WU2 A;  3QCH A;  2GC5 A;  3CWE A;  1J4X A;  1C85 A;  2Q05 A;  2I3U A;  4GS0 A;  1L8K A;  4OHD A;  3QCE A;  1P15 A;  2OUD A;  3LJ8 A;  2B07 A;  4JNB A;  3BM8 A;  1EEO A;  3O4T A;  2WGP A;  1ZC0 A;  1AAX A;  3V0J A;  2CFV A;  1C88 A;  2I3R A;  2NV5 A;  2QDP A;  2B4S A;  2PI7 A;  5K24 A;  1P3D A;  3N2A A;  2NLK A;  4CVK A;  4OHH A;  2F6T A;  4WOH A;  1PTY A;  1OEO X;  4CVL A;  1JF7 A;  1PYN A;  3F9A A;  3QCK A;  4H34 A;  2VTD A;  1G1H A;  2B4O A;  3H2X A;  1FPZ A;  1RXD A;  4KI9 A;  3B7O A;  5KAA A;  2M3V A;  2F6W A;  2CMB A;  1G7G A;  4RKK A;  1ZCK A;  2J16 B;  5A5E A;  3AWG A;  1OET A;  1Q6M A;  2Y68 A;  1FQ1 A;  4OHL A;  1BZH A;  2BZL A;  2I1Y A;  3ZM6 A;  1GQQ A;  1LQF A;  1OHC A;  2H04 A;  2BV5 A;  1P31 A;  2PSZ A;  2GJT A;  2CNF A;  2NZ6 A;  1PA1 A;  1WAX A;  2B3O A;  1FGS A;  1YZ4 A;  1ONZ A;  5IBM A;  2CJZ A;  2CM2 A;  2CMC A;  2RF6 A;  3ZM5 A;  4GFV A;  3V0G A;  1XRI A;  2CNE A;  3SME A;  5BZX A;  2F70 A;  2QBS A;  1GFY A;  1EEN A;  3QKQ A;  2HY3 A;  3S3F A;  1OES A;  5KAC A;  2VTE A;  1YGR A;  3QCB A;  1R6H A;  5K25 A;  2UAG A;  5KA8 A;  2CM3 A;  3EZZ A;  4IKC A;  4BUB A;  2QBR A;  5GTJ A;  5EHP A;  3V0E A;  3D42 A;  2JFH A;  3D1H A;  3QCG A;  1O5Z A;  1T49 A;  3QCI A;  3QCJ A;  1SUG A;  1U25 A;  5HDE A;  2Q47 A;  1C84 A;  5K9V A;  3RGQ A;  3MOW A;  1YTN A;  1OEU A;  2J16 A;  4D3Q A;  1OHD A;  1YFO A;  5KA3 A;  4QUM A;  5MMZ B;  1LAR A;  1Q6S A;  3S3E A;  5EHR A;  2F6Y A;  2VEW A;  2PA5 A;  1D5R A;  3EMU A;  3CM3 A;  2CM7 A;  2VOR A;  2QCJ A;  4BUC A;  4GRZ A; 
#chains in the Genus database with same CATH homology
 2VEX A;  3EAX A;  4YAA A;  3MMJ A;  3PS5 A;  2NT2 A;  4B04 A;  1G1F A;  4JMK A;  2E0T A;  2H4G A;  2P4D A;  3QCM A;  4ICZ A;  1X24 A;  4KYR A;  2QDM A;  3F99 A;  3D1Q A;  4WU3 A;  1T48 A;  1C83 A;  3QKP A;  5KA2 A;  1YTW A;  2A3K A;  4ZN5 A;  1PH0 A;  4GE2 A;  4RHG A;  1NWL A;  1BZJ A;  4RH5 A;  5LXQ B;  1Q6P A;  3S4O A;  1G1G A;  3QCD A;  2HC1 A;  1PXH A;  1ZZW A;  2C7S A;  1OEV A;  2HVL A;  1NZ7 A;  3O4U A;  4NND A;  2Y2F A;  4D3R A;  1GWZ A;  3AWE A;  4HRF A;  3GXG A;  4HJQ A;  5BX1 A;  1PTU A;  1Q6J A;  4AZ1 A;  5M43 A;  3NME A;  5AWX A;  2AHS A;  4GFU A;  3BLT A;  1WCH A;  2CMA A;  1XM2 A;  2VEU A;  3D9C A;  3ZM1 A;  2PT0 A;  4I8N A;  4S0G A;  4QAH A;  2YDU A;  2GP0 A;  4NWF A;  1C87 A;  1QXK A;  1KAV A;  3F9B A;  4JMJ A;  4R0T A;  2B49 A;  4TVV A;  1I57 A;  1WRM A;  2NTA A;  5J8R A;  2F46 A;  1VHR A;  3ZM3 A;  2F6V A;  5KA0 A;  4RDD A;  4Y2E A;  2VEV A;  1YGU A;  3EB1 A;  4PYH A;  2CNH A;  2BGD A;  3RGO A;  3ZV2 A;  2J17 A;  4NWG A;  4PVG A;  4DGP A;  3I7Z A;  2H02 A;  4RI4 A;  5BUG A;  4R30 A;  1U26 A;  2OC3 A;  1YN9 A;  2AZR A;  4GWF A;  2C46 A;  3QCL A;  2HNQ A;  5K9W A;  2GWO A;  2FH7 A;  2I4E A;  2QCT A;  4GE5 A;  2QEP A;  3EU0 A;  4DGX A;  2Y96 A;  3ZMQ A;  4JBC A;  2I4H A;  2G59 A;  2IMG A;  1NO6 A;  4QUN A;  4YR8 B;  4HJP A;  1PTV A;  5K23 A;  4MBB A;  2ESB A;  2ZN7 A;  3V0I A;  1Q6N A;  1Q6T A;  4NX8 A;  2I4G A;  3F81 A;  4GRY A;  4BJO A;  4NYH A;  1XXP A;  4QBW A;  3S3H A;  1PA9 A;  3D44 A;  3V0H A;  2HNP A;  1YWF A;  5I6V A;  4OHE A;  2I6O A;  4OHI A;  4BPC A;  1BZC A;  2H4V A;  4ZI4 A;  1OHE A;  3OLR A;  1ONY A;  2DXP A;  2F6Z A;  2PBN A;  4RH9 A;  1V3A A;  2VEY A;  3D1O A;  2R0B A;  5KAB A;  5IBS A;  2CNI A;  2QBP A;  2OZ5 A;  3ZMP A;  1I9T A;  1Q1M A;  2I5X A;  4D3P A;  2B4P A;  1JLN A;  1U24 A;  1YPT A;  3OMH A;  2FJN A;  3O3L A;  2I6I A;  1T4J A;  4Z6B A;  2I75 A;  5KA7 A;  2NT7 A;  3N0A A;  1G4U S;  3BLU A;  1OEM X;  5K22 A;  1NL9 A;  2JJD A;  2MBC A;  4QAP A;  2F6F A;  5KAD A;  3A5K A;  2FJM A;  3RO1 A;  1C86 A;  4GE6 A;  5KA1 A;  3QCC A;  1FPR A;  2B4U A;  3O4S A;  1PTT A;  1G7F A;  3M4U A;  4ZRT A;  4WTY A;  3V0D A;  1XBO A;  3I36 A;  4RI5 A;  2BGE A;  2F71 A;  2P6X A;  1ECV A;  2CM8 A;  5KA4 A;  1G4W R;  3GXH A;  2G6Z A;  2I6P A;  2PQ5 A;  3SR9 A;  2BIJ A;  1YTS A;  1ZCL A;  3ZM0 A;  4ERC A;  2HB1 A;  3S4E A;  1LYV A;  3F41 A;  2HC2 A;  2ZMM A;  3AWF A;  2HXP A;  4H1O A;  1RPM A;  4J51 A;  5BZZ A;  3I80 A;  2OOQ A;  4Y14 A;  1KAK A;  2QBQ A;  1I9S A;  3BRH A;  3ZM2 A;  1MKP A;  2I6J A;  1NNY A;  2HCM A;  2I6M A;  1A5Y A;  5KA9 A;  2H03 A;  2SHP A;  3A5J A;  4R0S A;  1XXV A;  3U96 A;  3S3K A;  1L8G A;  1NWE A;  4QBE A;  4KYQ A;  3V0F A;  2CNG A;  1M3G A;  3RZ2 A;  3QCN A;  2A8B A;  2QDC A;  2I42 A;  3QCF A;  2H4K A;  1QZ0 A;  3O5X A;  3MOZ A;  4WU2 A;  3QCH A;  3CWE A;  1J4X A;  1C85 A;  2Q05 A;  2I3U A;  4GS0 A;  1L8K A;  4OHD A;  3QCE A;  1P15 A;  2OUD A;  3LJ8 A;  2B07 A;  4JNB A;  3BM8 A;  1EEO A;  3O4T A;  2WGP A;  1ZC0 A;  1AAX A;  3V0J A;  2CFV A;  1C88 A;  2I3R A;  2NV5 A;  2QDP A;  2B4S A;  2PI7 A;  5K24 A;  2NLK A;  4OHH A;  2F6T A;  4WOH A;  1PTY A;  1OEO X;  1JF7 A;  1PYN A;  3F9A A;  3QCK A;  4H34 A;  1G1H A;  2B4O A;  3H2X A;  1FPZ A;  1RXD A;  4KI9 A;  3B7O A;  5KAA A;  2M3V A;  2F6W A;  2CMB A;  1G7G A;  4RKK A;  1ZCK A;  2J16 B;  3AWG A;  1OET A;  1Q6M A;  1FQ1 A;  4OHL A;  1BZH A;  2BZL A;  2I1Y A;  1LQF A;  1OHC A;  2H04 A;  2BV5 A;  2PSZ A;  2GJT A;  2CNF A;  2NZ6 A;  1PA1 A;  1WAX A;  2B3O A;  1YZ4 A;  1ONZ A;  5IBM A;  2CJZ A;  2CM2 A;  2CMC A;  2RF6 A;  4GFV A;  3V0G A;  1XRI A;  2CNE A;  3SME A;  5BZX A;  2F70 A;  2QBS A;  1GFY A;  1EEN A;  3QKQ A;  2HY3 A;  3S3F A;  1OES A;  5KAC A;  3QCB A;  1YGR A;  1R6H A;  5K25 A;  5KA8 A;  2CM3 A;  3EZZ A;  4IKC A;  2QBR A;  5GTJ A;  5EHP A;  3V0E A;  3D42 A;  3D1H A;  3QCG A;  1T49 A;  3QCI A;  3QCJ A;  1SUG A;  1U25 A;  5HDE A;  2Q47 A;  1C84 A;  5K9V A;  3RGQ A;  3MOW A;  1YTN A;  1OEU A;  2J16 A;  4D3Q A;  1OHD A;  1YFO A;  5KA3 A;  4QUM A;  5MMZ B;  1LAR A;  1Q6S A;  3S3E A;  5EHR A;  2F6Y A;  2VEW A;  2PA5 A;  1D5R A;  3EMU A;  3CM3 A;  2CM7 A;  2QCJ A;  4GRZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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