2HGFA

Hairpin loop containing domain of hepatocyte growth factor, nmr, minimized average structure
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
97
structure length
97
Chain Sequence
GQRKRRNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hepatocyte growth factor
molecule keywords HEPATOCYTE GROWTH FACTOR
publication title The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site.
pubmed doi rcsb
source organism Homo sapiens
total genus 14
structure length 97
sequence length 97
ec nomenclature
pdb deposition date 1997-12-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 2hgfA00
4IUAA 4Z0EA 5EOKA 1GMOA 2YIOA 2QJ4A 1I8NA 1NK1A 5CS1A 2Y8RA 4UV6A 5CSQA 4A5TS 4DURA 4Z0FA 3SRIA 4Z0DA 2HGFA 3ZLEA 4Z09A 3MKPA 4R1CA 2Q8BA 2LL3A 3SP8A 1YXEA 2Z8WA 4UAOA 2J8LA 1GP9A 1GMNA 4R1AA 2X2ZA 4R1BA 2K13X 2LL4M 5CS5A 4APLA 5CT1A 2J8JA 2YIPA 2YILA 3HN4A 1HKYA 2F83A 2QJ2A 5CS3A 4APMA 4R19A 3SRJA 3HMRA 3HMSA 3ZWZA 5EODA 2Q8AA 5CS9A 1W8KA 2Z8VA 5I25A 1Z40A 1W81A 5CT3A 1BHTA 5CP9A 5COEA 3HMTA 5CT2A
chains in the Genus database with same CATH superfamily
4IUAA 4Z0EA 5EOKA 1GMOA 2YIOA 2QJ4A 1I8NA 1NK1A 5CS1A 2Y8RA 4UV6A 5CSQA 4YIVA 4A5TS 4DURA 4Z0FA 3SRIA 4Z0DA 2HGFA 3ZLEA 4YIZA 4Z09A 3MKPA 4R1CA 2Q8BA 2LL3A 3SP8A 1YXEA 2Z8WA 4UAOA 2J8LA 1GP9A 1GMNA 4R1AA 2X2ZA 4R1BA 2K13X 2LL4M 5CS5A 4APLA 5CT1A 2J8JA 2YIPA 2YILA 3HN4A 1HKYA 2F83A 2QJ2A 5CS3A 4APMA 4R19A 3SRJA 3HMRA 3HMSA 3ZWZA 5EODA 2Q8AA 5CS9A 1W8KA 2KL5A 2Z8VA 5I25A 1Z40A 1W81A 5CT3A 1BHTA 5CP9A 5COEA 3HMTA 5CT2A
chains in the Genus database with same CATH topology
4IUAA 4Z0EA 5EOKA 1GMOA 2YIOA 2QJ4A 1I8NA 1NK1A 5CS1A 2Y8RA 4UV6A 5CSQA 4YIVA 4A5TS 4DURA 4Z0FA 3SRIA 4Z0DA 2HGFA 3ZLEA 4YIZA 4Z09A 3MKPA 4R1CA 2Q8BA 2LL3A 3SP8A 1YXEA 2Z8WA 4UAOA 2J8LA 1GP9A 1GMNA 4R1AA 2X2ZA 4R1BA 2K13X 2LL4M 5CS5A 4APLA 5CT1A 2J8JA 2YIPA 2YILA 3HN4A 1HKYA 2F83A 2QJ2A 5CS3A 4APMA 4R19A 3SRJA 3HMRA 3HMSA 3ZWZA 5EODA 2Q8AA 5CS9A 1W8KA 2KL5A 2Z8VA 5I25A 1Z40A 1W81A 5CT3A 1BHTA 5CP9A 5COEA 3HMTA 5CT2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IUA A;  4Z0E A;  5EOK A;  1GMO A;  2YIO A;  2QJ4 A;  1I8N A;  1NK1 A;  5CS1 A;  2Y8R A;  4UV6 A;  5CSQ A;  4A5T S;  4DUR A;  4Z0F A;  3SRI A;  4Z0D A;  2HGF A;  3ZLE A;  4Z09 A;  3MKP A;  4R1C A;  2Q8B A;  2LL3 A;  3SP8 A;  1YXE A;  2Z8W A;  4UAO A;  2J8L A;  1GP9 A;  1GMN A;  4R1A A;  2X2Z A;  4R1B A;  2K13 X;  2LL4 M;  5CS5 A;  4APL A;  5CT1 A;  2J8J A;  2YIP A;  2YIL A;  3HN4 A;  1HKY A;  2F83 A;  2QJ2 A;  5CS3 A;  4APM A;  4R19 A;  3SRJ A;  3HMR A;  3HMS A;  3ZWZ A;  5EOD A;  2Q8A A;  5CS9 A;  1W8K A;  2Z8V A;  5I25 A;  1Z40 A;  1W81 A;  5CT3 A;  1BHT A;  5CP9 A;  5COE A;  3HMT A;  5CT2 A; 
#chains in the Genus database with same CATH topology
 4IUA A;  4Z0E A;  5EOK A;  1GMO A;  2YIO A;  2QJ4 A;  1I8N A;  1NK1 A;  5CS1 A;  2Y8R A;  4UV6 A;  5CSQ A;  4YIV A;  4A5T S;  4DUR A;  4Z0F A;  3SRI A;  4Z0D A;  2HGF A;  3ZLE A;  4YIZ A;  4Z09 A;  3MKP A;  4R1C A;  2Q8B A;  2LL3 A;  3SP8 A;  1YXE A;  2Z8W A;  4UAO A;  2J8L A;  1GP9 A;  1GMN A;  4R1A A;  2X2Z A;  4R1B A;  2K13 X;  2LL4 M;  5CS5 A;  4APL A;  5CT1 A;  2J8J A;  2YIP A;  2YIL A;  3HN4 A;  1HKY A;  2F83 A;  2QJ2 A;  5CS3 A;  4APM A;  4R19 A;  3SRJ A;  3HMR A;  3HMS A;  3ZWZ A;  5EOD A;  2Q8A A;  5CS9 A;  1W8K A;  2KL5 A;  2Z8V A;  5I25 A;  1Z40 A;  1W81 A;  5CT3 A;  1BHT A;  5CP9 A;  5COE A;  3HMT A;  5CT2 A; 
#chains in the Genus database with same CATH homology
 4IUA A;  4Z0E A;  5EOK A;  1GMO A;  2YIO A;  2QJ4 A;  1I8N A;  1NK1 A;  5CS1 A;  2Y8R A;  4UV6 A;  5CSQ A;  4YIV A;  4A5T S;  4DUR A;  4Z0F A;  3SRI A;  4Z0D A;  2HGF A;  3ZLE A;  4YIZ A;  4Z09 A;  3MKP A;  4R1C A;  2Q8B A;  2LL3 A;  3SP8 A;  1YXE A;  2Z8W A;  4UAO A;  2J8L A;  1GP9 A;  1GMN A;  4R1A A;  2X2Z A;  4R1B A;  2K13 X;  2LL4 M;  5CS5 A;  4APL A;  5CT1 A;  2J8J A;  2YIP A;  2YIL A;  3HN4 A;  1HKY A;  2F83 A;  2QJ2 A;  5CS3 A;  4APM A;  4R19 A;  3SRJ A;  3HMR A;  3HMS A;  3ZWZ A;  5EOD A;  2Q8A A;  5CS9 A;  1W8K A;  2KL5 A;  2Z8V A;  5I25 A;  1Z40 A;  1W81 A;  5CT3 A;  1BHT A;  5CP9 A;  5COE A;  3HMT A;  5CT2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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