2HYPA

Crystal structure of rv0805 d66a mutant
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
256
structure length
230
Chain Sequence
PRPDYVLLHISDTHLIGGDDADDRLGELLEQLNQSGLRPDAIVFTGDLAAKGEPAAYRKLRGLVEPFAAQLGAELVWVMGNHDDRAELRKFLLDEAPSMAPLDRVCMIDGLRIIVLDTSVPGHHHGEIRASQLGWLAEELATPAPDGTILALHHPPIPSVLDMAVTVELRDQAALGRVLRGTDVRAILAGHLHYSTNATFVGIPVSVASATCGCNLVHVYPDTVVHSVIP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Biochemical Analysis of the Rv0805 Cyclic Nucleotide Phosphodiesterase from Mycobacterium tuberculosis.
pubmed doi rcsb
molecule keywords Hypothetical protein RV0805
molecule tags Hydrolase
source organism Mycobacterium tuberculosis
total genus 69
structure length 230
sequence length 256
ec nomenclature ec 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
pdb deposition date 2006-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2hypA00
4OR9A 3H69A 3E7BA 3H68A 1UF3A 4YKEA 4HD0A 3IB8A 1S95A 1S3MA 2HYPA 1G5BA 3EGHA 1QHWA 5JPEA 3THNA 1HPUA 1U32A 3PSNA 3E7AA 4IL1A 5EQVA 2R17A 4NZVA 3QFNA 4UT3A 2A22A 4H1YP 1SU1A 5JJTA 4DT2A 3DSDA 2Z1AA 1WARA 2HYOA 4I5NC 4ORBA 2ZBMA 4V0VA 4XPNA 1UTEA 1OIDA 4JA9A 4H2IA 3DSCA 4TUGA 1II7A 2NYMC 2Z72A 3IB7A 4O5GA 3IVEA 4FCXA 1KBPA 2GJUA 4M0VA 3RL3A 2CV9A 2BQ8X 3QFMA 3H66A 5DNYA 1XZWA 2WDCA 4MOYA 4MP0A 4WWLA 3LL8A 4FBKA 2BCDA 3K7WC 3QFKA 4FBWA 4G9JA 1XM7A 5GTUA 3HVQA 3H62B 2Q8UA 2HY1A 3P71C 3H64A 4B2OA 3N5UA 1S3LA 5B8IA 2NXFA 4V0XA 5INBA 4H1SA 2AHDA 4LU9A 3CK2A 3T1IA 4I5LC 2WDDA 1TCOA 2WDFA 3H67A 4LACC 4O43A 4JA7A 5IOHA 3EGGA 3H60A 2O8GA 4H2FA 1NNWA 3GVEA 4IYPC 1JK7A 2QJCA 4ZVZA 1QFCA 4V0WA 3QG5C 5HPEA 1V73A 2JOGA 4H2BA 2QFPA 3ICFA 3IVDA 4H2GA 3V4YA 3KBPA 2DFJA 4LTYA 2WDEA 2NPPC 4UWQA 4J6OA 4ORAA 3PSOA 4Q7FA 1OI8A 1HO5A 2NYLC 2Z06A 3H61A 5F3WA 3C9FA 2BDXA 3RL5A 1T70A 3ZU0A 2O8AA 1HP1A 1S3NA 1IT6A 4KBPA 4ORCA 2IE4C 3THOB 1S70A 5C1VA 3H63A 5JPFA 4UT3B 2USHA 4MOVA 3AV0A 4KKZA 1W24A 4FBQA 3JYFA 4O24A 5J28A 1M63A 2YVTA 4ZX2A 4O4KA 4DHLA 2QFRA 2IAEC 2XMOA 3RQZA 3QFOA 3TGHA 1T71A 3FGAC 1WAO1 1USHA 3K7VC 1S8EA 1Z2WA 4DSYA 3DW8C 4UT2A 4F0ZA 4TUIA 1Z2XA 3AUZA 1MF8A 3C5WC 1OIEA 1FJMA 3RL4A 2IE3C 3ZTVA 2KKNA 1AUIA 2P6BA
chains in the Genus database with same CATH superfamily
4OR9A 3H69A 3E7BA 3H68A 1UF3A 4YKEA 4HD0A 3IB8A 1S95A 1S3MA 2DXNA 2HYPA 1G5BA 3EGHA 1QHWA 5JPEA 3THNA 1HPUA 1U32A 3PSNA 3E7AA 4IL1A 5EQVA 2R17A 4NZVA 3QFNA 4UT3A 2A22A 3FLOA 4H1YP 1SU1A 5JJTA 4DT2A 3DSDA 2Z1AA 1WARA 2HYOA 2ZOAA 4I5NC 4ORBA 2ZBMA 4V0VA 4XPNA 1UTEA 1OIDA 3D03A 4H2IA 4JA9A 3DSCA 4TUGA 1II7A 2NYMC 2Z72A 3IB7A 2YEQA 4O5GA 3IVEA 4FCXA 1KBPA 2GJUA 4M0VA 3RL3A 2CV9A 2BQ8X 3QFMA 3H66A 5DNYA 1XZWA 2WDCA 4MOYA 4MP0A 4WWLA 3LL8A 4FBKA 2BCDA 3K7WC 3QFKA 4FBWA 4G9JA 1XM7A 5GTUA 3HVQA 3H62B 2Q8UA 2HY1A 3P71C 3H64A 4B2OA 3N5UA 1S3LA 2ZO9B 5B8IA 2NXFA 4V0XA 5INBA 4H1SA 2AHDA 4LU9A 3CK2A 3T1IA 4I5LC 2WDDA 1TCOA 2WDFA 3H67A 4LACC 4O43A 4JA7A 5IOHA 3EGGA 3H60A 2O8GA 4H2FA 1NNWA 3GVEA 4IYPC 1JK7A 2QJCA 4ZVZA 2DXLA 1QFCA 4V0WA 3QG5C 5HPEA 1V73A 2JOGA 4H2BA 2QFPA 3ICFA 3IVDA 4H2GA 3V4YA 3KBPA 2DFJA 4LTYA 2WDEA 2NPPC 4UWQA 4J6OA 4ORAA 3PSOA 4Q7FA 1OI8A 1HO5A 2NYLC 2Z06A 3H61A 5F3WA 3C9FA 2BDXA 3RL5A 1T70A 3ZU0A 2O8AA 1HP1A 1S3NA 1IT6A 4KBPA 4ORCA 2IE4C 3THOB 1S70A 5C1VA 3H63A 5JPFA 4UT3B 2USHA 4MOVA 3AV0A 4KKZA 1W24A 4FBQA 3JYFA 4O24A 5J28A 1M63A 2YVTA 4ZX2A 4O4KA 4DHLA 2QFRA 2IAEC 2XMOA 3RQZA 3QFOA 3E0JA 3TGHA 1T71A 3FGAC 1WAO1 1USHA 3K7VC 1S8EA 1Z2WA 4DSYA 3DW8C 4UT2A 4F0ZA 4TUIA 1Z2XA 3AUZA 1MF8A 3C5WC 1OIEA 1FJMA 3RL4A 2IE3C 3ZTVA 2KKNA 1AUIA 2P6BA
chains in the Genus database with same CATH topology
4OR9A 3H69A 3E7BA 3H68A 1UF3A 4YKEA 4HD0A 3IB8A 1S95A 1S3MA 2DXNA 2HYPA 1G5BA 3EGHA 1QHWA 5JPEA 3THNA 1HPUA 1U32A 3PSNA 3E7AA 4IL1A 5EQVA 2R17A 4NZVA 3QFNA 4UT3A 2A22A 3FLOA 4H1YP 1SU1A 5JJTA 4DT2A 3DSDA 2Z1AA 1WARA 2HYOA 2ZOAA 4I5NC 4ORBA 2ZBMA 4V0VA 4XPNA 1UTEA 1OIDA 3D03A 4H2IA 4JA9A 3DSCA 4TUGA 1II7A 2NYMC 2Z72A 3IB7A 2YEQA 4O5GA 3IVEA 4FCXA 1KBPA 2GJUA 4M0VA 3RL3A 2CV9A 2BQ8X 3QFMA 3H66A 5DNYA 1XZWA 2WDCA 4MOYA 4MP0A 4WWLA 3LL8A 4FBKA 2BCDA 3K7WC 3QFKA 4FBWA 4G9JA 1XM7A 5GTUA 3HVQA 3H62B 2Q8UA 2HY1A 3P71C 3H64A 4B2OA 3N5UA 1S3LA 2ZO9B 5B8IA 2NXFA 4V0XA 5INBA 4H1SA 2AHDA 4LU9A 3CK2A 3T1IA 4I5LC 2WDDA 1TCOA 2WDFA 3H67A 4LACC 4O43A 4JA7A 5IOHA 3EGGA 3H60A 2O8GA 4H2FA 1NNWA 3GVEA 4IYPC 1JK7A 2QJCA 4ZVZA 2DXLA 1QFCA 4V0WA 3QG5C 5HPEA 1V73A 2JOGA 4H2BA 2QFPA 3ICFA 3IVDA 4H2GA 3V4YA 3KBPA 2DFJA 4LTYA 2WDEA 2NPPC 4UWQA 4J6OA 4ORAA 3PSOA 4Q7FA 1OI8A 1HO5A 2NYLC 2Z06A 3H61A 5F3WA 3C9FA 2BDXA 3RL5A 1T70A 3ZU0A 2O8AA 1HP1A 1S3NA 1IT6A 4KBPA 4ORCA 2IE4C 3THOB 1S70A 5C1VA 3H63A 5JPFA 4UT3B 2USHA 4MOVA 3AV0A 4KKZA 1W24A 4FBQA 3JYFA 4O24A 5J28A 1M63A 2YVTA 4ZX2A 4O4KA 4DHLA 2QFRA 2IAEC 2XMOA 3RQZA 3QFOA 3E0JA 3TGHA 1T71A 3FGAC 1WAO1 1USHA 3K7VC 1S8EA 1Z2WA 4DSYA 3DW8C 4UT2A 4F0ZA 4TUIA 1Z2XA 3AUZA 1MF8A 3C5WC 1OIEA 1FJMA 3RL4A 2IE3C 3ZTVA 2KKNA 1AUIA 2P6BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OR9 A;  3H69 A;  3E7B A;  3H68 A;  1UF3 A;  4YKE A;  4HD0 A;  3IB8 A;  1S95 A;  1S3M A;  2HYP A;  1G5B A;  3EGH A;  1QHW A;  5JPE A;  3THN A;  1HPU A;  1U32 A;  3PSN A;  3E7A A;  4IL1 A;  5EQV A;  2R17 A;  4NZV A;  3QFN A;  4UT3 A;  2A22 A;  4H1Y P;  1SU1 A;  5JJT A;  4DT2 A;  3DSD A;  2Z1A A;  1WAR A;  2HYO A;  4I5N C;  4ORB A;  2ZBM A;  4V0V A;  4XPN A;  1UTE A;  1OID A;  4JA9 A;  4H2I A;  3DSC A;  4TUG A;  1II7 A;  2NYM C;  2Z72 A;  3IB7 A;  4O5G A;  3IVE A;  4FCX A;  1KBP A;  2GJU A;  4M0V A;  3RL3 A;  2CV9 A;  2BQ8 X;  3QFM A;  3H66 A;  5DNY A;  1XZW A;  2WDC A;  4MOY A;  4MP0 A;  4WWL A;  3LL8 A;  4FBK A;  2BCD A;  3K7W C;  3QFK A;  4FBW A;  4G9J A;  1XM7 A;  5GTU A;  3HVQ A;  3H62 B;  2Q8U A;  2HY1 A;  3P71 C;  3H64 A;  4B2O A;  3N5U A;  1S3L A;  5B8I A;  2NXF A;  4V0X A;  5INB A;  4H1S A;  2AHD A;  4LU9 A;  3CK2 A;  3T1I A;  4I5L C;  2WDD A;  1TCO A;  2WDF A;  3H67 A;  4LAC C;  4O43 A;  4JA7 A;  5IOH A;  3EGG A;  3H60 A;  2O8G A;  4H2F A;  1NNW A;  3GVE A;  4IYP C;  1JK7 A;  2QJC A;  4ZVZ A;  1QFC A;  4V0W A;  3QG5 C;  5HPE A;  1V73 A;  2JOG A;  4H2B A;  2QFP A;  3ICF A;  3IVD A;  4H2G A;  3V4Y A;  3KBP A;  2DFJ A;  4LTY A;  2WDE A;  2NPP C;  4UWQ A;  4J6O A;  4ORA A;  3PSO A;  4Q7F A;  1OI8 A;  1HO5 A;  2NYL C;  2Z06 A;  3H61 A;  5F3W A;  3C9F A;  2BDX A;  3RL5 A;  1T70 A;  3ZU0 A;  2O8A A;  1HP1 A;  1S3N A;  1IT6 A;  4KBP A;  4ORC A;  2IE4 C;  3THO B;  1S70 A;  5C1V A;  3H63 A;  5JPF A;  4UT3 B;  2USH A;  4MOV A;  3AV0 A;  4KKZ A;  1W24 A;  4FBQ A;  3JYF A;  4O24 A;  5J28 A;  1M63 A;  2YVT A;  4ZX2 A;  4O4K A;  4DHL A;  2QFR A;  2IAE C;  2XMO A;  3RQZ A;  3QFO A;  3TGH A;  1T71 A;  3FGA C;  1WAO 1;  1USH A;  3K7V C;  1S8E A;  1Z2W A;  4DSY A;  3DW8 C;  4UT2 A;  4F0Z A;  4TUI A;  1Z2X A;  3AUZ A;  1MF8 A;  3C5W C;  1OIE A;  1FJM A;  3RL4 A;  2IE3 C;  3ZTV A;  2KKN A;  1AUI A;  2P6B A; 
#chains in the Genus database with same CATH topology
 4OR9 A;  3H69 A;  3E7B A;  3H68 A;  1UF3 A;  4YKE A;  4HD0 A;  3IB8 A;  1S95 A;  1S3M A;  2DXN A;  2HYP A;  1G5B A;  3EGH A;  1QHW A;  5JPE A;  3THN A;  1HPU A;  1U32 A;  3PSN A;  3E7A A;  4IL1 A;  5EQV A;  2R17 A;  4NZV A;  3QFN A;  4UT3 A;  2A22 A;  3FLO A;  4H1Y P;  1SU1 A;  5JJT A;  4DT2 A;  3DSD A;  2Z1A A;  1WAR A;  2HYO A;  2ZOA A;  4I5N C;  4ORB A;  2ZBM A;  4V0V A;  4XPN A;  1UTE A;  1OID A;  3D03 A;  4H2I A;  4JA9 A;  3DSC A;  4TUG A;  1II7 A;  2NYM C;  2Z72 A;  3IB7 A;  2YEQ A;  4O5G A;  3IVE A;  4FCX A;  1KBP A;  2GJU A;  4M0V A;  3RL3 A;  2CV9 A;  2BQ8 X;  3QFM A;  3H66 A;  5DNY A;  1XZW A;  2WDC A;  4MOY A;  4MP0 A;  4WWL A;  3LL8 A;  4FBK A;  2BCD A;  3K7W C;  3QFK A;  4FBW A;  4G9J A;  1XM7 A;  5GTU A;  3HVQ A;  3H62 B;  2Q8U A;  2HY1 A;  3P71 C;  3H64 A;  4B2O A;  3N5U A;  1S3L A;  2ZO9 B;  5B8I A;  2NXF A;  4V0X A;  5INB A;  4H1S A;  2AHD A;  4LU9 A;  3CK2 A;  3T1I A;  4I5L C;  2WDD A;  1TCO A;  2WDF A;  3H67 A;  4LAC C;  4O43 A;  4JA7 A;  5IOH A;  3EGG A;  3H60 A;  2O8G A;  4H2F A;  1NNW A;  3GVE A;  4IYP C;  1JK7 A;  2QJC A;  4ZVZ A;  2DXL A;  1QFC A;  4V0W A;  3QG5 C;  5HPE A;  1V73 A;  2JOG A;  4H2B A;  2QFP A;  3ICF A;  3IVD A;  4H2G A;  3V4Y A;  3KBP A;  2DFJ A;  4LTY A;  2WDE A;  2NPP C;  4UWQ A;  4J6O A;  4ORA A;  3PSO A;  4Q7F A;  1OI8 A;  1HO5 A;  2NYL C;  2Z06 A;  3H61 A;  5F3W A;  3C9F A;  2BDX A;  3RL5 A;  1T70 A;  3ZU0 A;  2O8A A;  1HP1 A;  1S3N A;  1IT6 A;  4KBP A;  4ORC A;  2IE4 C;  3THO B;  1S70 A;  5C1V A;  3H63 A;  5JPF A;  4UT3 B;  2USH A;  4MOV A;  3AV0 A;  4KKZ A;  1W24 A;  4FBQ A;  3JYF A;  4O24 A;  5J28 A;  1M63 A;  2YVT A;  4ZX2 A;  4O4K A;  4DHL A;  2QFR A;  2IAE C;  2XMO A;  3RQZ A;  3QFO A;  3E0J A;  3TGH A;  1T71 A;  3FGA C;  1WAO 1;  1USH A;  3K7V C;  1S8E A;  1Z2W A;  4DSY A;  3DW8 C;  4UT2 A;  4F0Z A;  4TUI A;  1Z2X A;  3AUZ A;  1MF8 A;  3C5W C;  1OIE A;  1FJM A;  3RL4 A;  2IE3 C;  3ZTV A;  2KKN A;  1AUI A;  2P6B A; 
#chains in the Genus database with same CATH homology
 4OR9 A;  3H69 A;  3E7B A;  3H68 A;  1UF3 A;  4YKE A;  4HD0 A;  3IB8 A;  1S95 A;  1S3M A;  2DXN A;  2HYP A;  1G5B A;  3EGH A;  1QHW A;  5JPE A;  3THN A;  1HPU A;  1U32 A;  3PSN A;  3E7A A;  4IL1 A;  5EQV A;  2R17 A;  4NZV A;  3QFN A;  4UT3 A;  2A22 A;  3FLO A;  4H1Y P;  1SU1 A;  5JJT A;  4DT2 A;  3DSD A;  2Z1A A;  1WAR A;  2HYO A;  2ZOA A;  4I5N C;  4ORB A;  2ZBM A;  4V0V A;  4XPN A;  1UTE A;  1OID A;  3D03 A;  4H2I A;  4JA9 A;  3DSC A;  4TUG A;  1II7 A;  2NYM C;  2Z72 A;  3IB7 A;  2YEQ A;  4O5G A;  3IVE A;  4FCX A;  1KBP A;  2GJU A;  4M0V A;  3RL3 A;  2CV9 A;  2BQ8 X;  3QFM A;  3H66 A;  5DNY A;  1XZW A;  2WDC A;  4MOY A;  4MP0 A;  4WWL A;  3LL8 A;  4FBK A;  2BCD A;  3K7W C;  3QFK A;  4FBW A;  4G9J A;  1XM7 A;  5GTU A;  3HVQ A;  3H62 B;  2Q8U A;  2HY1 A;  3P71 C;  3H64 A;  4B2O A;  3N5U A;  1S3L A;  2ZO9 B;  5B8I A;  2NXF A;  4V0X A;  5INB A;  4H1S A;  2AHD A;  4LU9 A;  3CK2 A;  3T1I A;  4I5L C;  2WDD A;  1TCO A;  2WDF A;  3H67 A;  4LAC C;  4O43 A;  4JA7 A;  5IOH A;  3EGG A;  3H60 A;  2O8G A;  4H2F A;  1NNW A;  3GVE A;  4IYP C;  1JK7 A;  2QJC A;  4ZVZ A;  2DXL A;  1QFC A;  4V0W A;  3QG5 C;  5HPE A;  1V73 A;  2JOG A;  4H2B A;  2QFP A;  3ICF A;  3IVD A;  4H2G A;  3V4Y A;  3KBP A;  2DFJ A;  4LTY A;  2WDE A;  2NPP C;  4UWQ A;  4J6O A;  4ORA A;  3PSO A;  4Q7F A;  1OI8 A;  1HO5 A;  2NYL C;  2Z06 A;  3H61 A;  5F3W A;  3C9F A;  2BDX A;  3RL5 A;  1T70 A;  3ZU0 A;  2O8A A;  1HP1 A;  1S3N A;  1IT6 A;  4KBP A;  4ORC A;  2IE4 C;  3THO B;  1S70 A;  5C1V A;  3H63 A;  5JPF A;  4UT3 B;  2USH A;  4MOV A;  3AV0 A;  4KKZ A;  1W24 A;  4FBQ A;  3JYF A;  4O24 A;  5J28 A;  1M63 A;  2YVT A;  4ZX2 A;  4O4K A;  4DHL A;  2QFR A;  2IAE C;  2XMO A;  3RQZ A;  3QFO A;  3E0J A;  3TGH A;  1T71 A;  3FGA C;  1WAO 1;  1USH A;  3K7V C;  1S8E A;  1Z2W A;  4DSY A;  3DW8 C;  4UT2 A;  4F0Z A;  4TUI A;  1Z2X A;  3AUZ A;  1MF8 A;  3C5W C;  1OIE A;  1FJM A;  3RL4 A;  2IE3 C;  3ZTV A;  2KKN A;  1AUI A;  2P6B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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