2HYVA

Human annexin a2 with heparin hexasaccharide bound
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
308
structure length
308
Chain Sequence
NFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Annexin A2
publication title Crystallographic analysis of calcium-dependent heparin binding to annexin A2.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Metal binding protein
total genus 131
structure length 308
sequence length 308
ec nomenclature
pdb deposition date 2006-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyvA04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyvA01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyvA02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyvA03
1YCNA 1ALAA 1YJ0A 4EVFA 4X9PA 1AIIA 1ANWA 2Q4CA 1BC1A 1BCZA 1W3WA 1A8BA 1AOWA 1HVEA 1A8AA 2II2A 2H0KA 2ZHIA 1G5NA 2HYVA 2IICA 1AVCA 1HAKA 1I4AA 1N44A 1SAVA 1HM6A 2IE6A 2H0LA 1M9IA 1AVRA 1BCWA 1N42A 2RANA 2IE7A 2XO3A 1ANNA 2HYUA 2ZHJA 3BRXA 4MDUA 1BC0A 4EVHA 1DK5A 1BC3A 1AEIA 1HVDA 1HVFA 1AVHA 1ANXA 1N00A 1MCXA 2HYWA 1BO9A 1DM5A 1AXNA 1HVGA 2H0MA 2XO2A 1W45A 1BCYA 1YIIA 4MDVA 1N41A 2ZOCA 1XJLA 1W7BA 4HREA
chains in the Genus database with same CATH superfamily
1Q8DA 4FHRB 4X9PA 2R09A 4Z21A 2Q4CA 1BC9A 3SOHB 4JK1X 2II2A 2ZHIA 1AVCA 1SAVA 1HM6A 4OIYA 1N42A 1AVRA 1BCWA 3TW5A 3USWA 2ZHJA 1ANNA 1QC7A 4EVHA 4JMIA 1N00A 1ANXA 4JXHA 1DM5A 2H0MA 2XO2A 1RE0B 1R4AE 4MDVA 3ABSA 4C0AA 1W7BA 3ABRA 4KN7X 2VXGA 1ALAA 4KN4X 3ANYA 4C7PA 4KMUX 4Q2SA 1R8ME 1W3WA 4JWLA 2H0KA 4JMOA 1HAKA 4A4PA 1PBVA 3ABQA 2IE7A 2XO3A 4MDUA 1DK5A 1AEIA 2OY9A 2HYWA 3SWVA 1HVGA 3L8NA 1YIIA 1N41A 1KU1A 2ZOCA 1XJLA 1UPTB 1YCNA 1YJ0A 1XT0B 2K6XA 1AIIA 1ANWA 1YGMA 1BC1A 1AOWA 1A8AA 1G5NA 2HYVA 1C1KA 1N44A 3AJCA 2H0LA 2RANA 4D7RA 2HSNA 1BC3A 1HVFA 1AVHA 1MCXA 1R8SE 1W45A 1BCYA 1XSZA 4D7QA 4EVFA 3ABOA 3AO0A 3USYA 1BCZA 1A8BA 1R8QE 1HVEA 1LKVX 4L5MA 2IICA 1I4AA 2QEZA 2IE6A 1M9IA 2HYUA 1BC0A 1S9DE 2R0DA 1HVDA 3LTLA 1BO9A 1AXNA 4FQ0C 3HJLA 3BRXA 4HREA
chains in the Genus database with same CATH topology
1YCNA 1ALAA 1YJ0A 4EVFA 4X9PA 1AIIA 1ANWA 2Q4CA 1BC1A 1BCZA 1W3WA 1A8BA 1AOWA 1HVEA 1A8AA 2II2A 2H0KA 2ZHIA 1G5NA 2HYVA 2IICA 1AVCA 1HAKA 1I4AA 1N44A 1SAVA 1HM6A 2IE6A 2H0LA 1M9IA 1AVRA 1BCWA 1N42A 2RANA 2IE7A 2XO3A 1ANNA 2HYUA 2ZHJA 3BRXA 4MDUA 1BC0A 4EVHA 1DK5A 1BC3A 1AEIA 1HVDA 1HVFA 1AVHA 1ANXA 1N00A 1MCXA 2HYWA 1BO9A 1DM5A 1AXNA 1HVGA 2H0MA 2XO2A 1W45A 1BCYA 1YIIA 4MDVA 1N41A 2ZOCA 1XJLA 1W7BA 4HREA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YCN A;  1ALA A;  1YJ0 A;  4EVF A;  4X9P A;  1AII A;  1ANW A;  2Q4C A;  1BC1 A;  1BCZ A;  1W3W A;  1A8B A;  1AOW A;  1HVE A;  1A8A A;  2II2 A;  2H0K A;  2ZHI A;  1G5N A;  2HYV A;  2IIC A;  1AVC A;  1HAK A;  1I4A A;  1N44 A;  1SAV A;  1HM6 A;  2IE6 A;  2H0L A;  1M9I A;  1AVR A;  1BCW A;  1N42 A;  2RAN A;  2IE7 A;  2XO3 A;  1ANN A;  2HYU A;  2ZHJ A;  3BRX A;  4MDU A;  1BC0 A;  4EVH A;  1DK5 A;  1BC3 A;  1AEI A;  1HVD A;  1HVF A;  1AVH A;  1ANX A;  1N00 A;  1MCX A;  2HYW A;  1BO9 A;  1DM5 A;  1AXN A;  1HVG A;  2H0M A;  2XO2 A;  1W45 A;  1BCY A;  1YII A;  4MDV A;  1N41 A;  2ZOC A;  1XJL A;  1W7B A;  4HRE A; 
#chains in the Genus database with same CATH topology
 1Q8D A;  4FHR B;  4X9P A;  2R09 A;  4Z21 A;  2Q4C A;  1BC9 A;  3SOH B;  4JK1 X;  2II2 A;  2ZHI A;  1AVC A;  1SAV A;  1HM6 A;  4OIY A;  1N42 A;  1AVR A;  1BCW A;  3TW5 A;  3USW A;  2ZHJ A;  1ANN A;  1QC7 A;  4EVH A;  4JMI A;  1N00 A;  1ANX A;  4JXH A;  1DM5 A;  2H0M A;  2XO2 A;  1RE0 B;  1R4A E;  4MDV A;  3ABS A;  4C0A A;  1W7B A;  3ABR A;  4KN7 X;  2VXG A;  1ALA A;  4KN4 X;  3ANY A;  4C7P A;  4KMU X;  4Q2S A;  1R8M E;  1W3W A;  4JWL A;  2H0K A;  4JMO A;  1HAK A;  4A4P A;  1PBV A;  3ABQ A;  2IE7 A;  2XO3 A;  4MDU A;  1DK5 A;  1AEI A;  2OY9 A;  2HYW A;  3SWV A;  1HVG A;  3L8N A;  1YII A;  1N41 A;  1KU1 A;  2ZOC A;  1XJL A;  1UPT B;  1YCN A;  1YJ0 A;  1XT0 B;  2K6X A;  1AII A;  1ANW A;  1YGM A;  1BC1 A;  1AOW A;  1A8A A;  1G5N A;  2HYV A;  1C1K A;  1N44 A;  3AJC A;  2H0L A;  2RAN A;  4D7R A;  2HSN A;  1BC3 A;  1HVF A;  1AVH A;  1MCX A;  1R8S E;  1W45 A;  1BCY A;  1XSZ A;  4D7Q A;  4EVF A;  3ABO A;  3AO0 A;  3USY A;  1BCZ A;  1A8B A;  1R8Q E;  1HVE A;  1LKV X;  4L5M A;  2IIC A;  1I4A A;  2QEZ A;  2IE6 A;  1M9I A;  2HYU A;  1BC0 A;  1S9D E;  2R0D A;  1HVD A;  3LTL A;  1BO9 A;  1AXN A;  4FQ0 C;  3HJL A;  3BRX A;  4HRE A; 
#chains in the Genus database with same CATH homology
 1YCN A;  1ALA A;  1YJ0 A;  4EVF A;  4X9P A;  1AII A;  1ANW A;  2Q4C A;  1BC1 A;  1BCZ A;  1W3W A;  1A8B A;  1AOW A;  1HVE A;  1A8A A;  2II2 A;  2H0K A;  2ZHI A;  1G5N A;  2HYV A;  2IIC A;  1AVC A;  1HAK A;  1I4A A;  1N44 A;  1SAV A;  1HM6 A;  2IE6 A;  2H0L A;  1M9I A;  1AVR A;  1BCW A;  1N42 A;  2RAN A;  2IE7 A;  2XO3 A;  1ANN A;  2HYU A;  2ZHJ A;  3BRX A;  4MDU A;  1BC0 A;  4EVH A;  1DK5 A;  1BC3 A;  1AEI A;  1HVD A;  1HVF A;  1AVH A;  1ANX A;  1N00 A;  1MCX A;  2HYW A;  1BO9 A;  1DM5 A;  1AXN A;  1HVG A;  2H0M A;  2XO2 A;  1W45 A;  1BCY A;  1YII A;  4MDV A;  1N41 A;  2ZOC A;  1XJL A;  1W7B A;  4HRE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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