2IESA

Crystal structure of aquifex aeolicus lpxc complexed with pyrophosphate
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
267
structure length
267
Chain Sequence
GLEKTVKEKLSFEGVGIHTGEYSKLIIHPEKEGTGIRFFKNGVYIPARHEFVVHTNHSTDLGFKGQRIKTVEHILSVLHLLEITNVTIEVIGNEIPILDGSGWEFYEAIRKNILNQNREIDYFVVEEPIIVEDEGRLIKAEPSDTLEVTYEGEFKNFLGRQKFTFVEGNEEEIVLARTFAFDWEIEHIKKVGLGKGGSLKNTLVLGKDKVYNPEGLRYENEPVRHKVFDLIGDLYLLGSPVKGKFYSFRGGHSLNVKLVKELAKKQK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Binding of Uridine 5-Diphosphate in the Basic Patch of the Zinc Metalloenzyme Deacetylase LpxC and Implications for Substrate Binding
pubmed doi rcsb
molecule tags Hydrolase
source organism Aquifex aeolicus
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 85
structure length 267
sequence length 267
chains with identical sequence B
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2006-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 2iesA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 2iesA02
4LCFA 1YHCA 2J65A 4FW3A 4LCGA 3P3CA 4IS9A 3PS2A 2IESA 5DRPA 4U3DA 4OKGA 4FW4A 4U3BA 5DRQA 2GO3A 4OZEA 4FW7A 4FW6A 4J3DA 1XXEA 5DROA 2IERA 4FW5A 1YH8A 3PS1A 3P3EA 4LCHA 5DRRA 3UHMA 4MQYA 2VESA 3PS3A 1P42A 3U1YA 4ISAA 2GO4A 3P76A 3NZKA 2JT2A 4MDTA 3P3GA 2O3ZA
chains in the Genus database with same CATH superfamily
2NPFA 2HKEA 4JI6E 4MU3A 4DPWA 1N36I 4DV2E 3K1JA 2JE6A 3H1CA 1S16A 4FWGA 2AE8A 4DUZE 1ZM9A 4MU0A 1FNMA 5BR8E 4IFDA 5DROA 1IBLE 4X64E 4B3MI 2V2ZA 4IZJA 4DPYA 3WU3A 4OO1A 2O1UA 1IBME 4IFDD 1NHIA 4JI2I 2HFSA 4DXLA 3K85A 4IZJD 4DV7E 2BM1A 2UUAI 2HK2A 1N36E 1ZXMA 2PO0A 4WUDA 4JI5I 3L7ZB 3HULA 4IFDE 4FW6A 1XNRE 1VI7A 2WNRA 5JEAF 2AJ4A 2HFUA 4ED4A 1OYPA 1KVKA 3GCMA 2ZM6I 5LMNE 1N0UA 3B4TA 2GO4A 1Z5CA 4JI2E 1H74A 5JEAC 5A2QC 1OYRA 3V2UC 1Z0GA 3OTOI 2NN6A 3WU5A 3CWVA 5LMUI 4NXME 2UXCE 1Y4SA 1Y6ZA 4DR4E 2Z5BB 4JI5E 2PNLA 2NN6D 2BA1D 4LCHA 3T1HI 1P42A 4JI0I 5JEAB 4DR5I 3J7AG 2XEXA 4LF4I 2VF3A 2HHHI 2UU9I 4YHHI 3K17A 4LFCI 4PU9A 1XNQE 2BA1G 3M7ND 2E1RA 3CDIA 2NN6E 2BV3A 5IWAI 1Z5AA 1Z5BA 4LFAI 1Z0TA 3P06A 4U3DA 4LF8I 4FN5A 2JEAA 2OI2A 4X62I 1DARA 5L3JA 4JYAI 1HNZI 4OX9E 5LMUE 1UDNA 3F0NA 3PYFA 3M7NG 4B3SI 1N33I 4JI7I 3T1HE 4JI0E 1ELOA 1PKPA 3Q6MA 1NZ0A 4JI4E 3NZKA 3B82A 2A2CA 4BA1B 2HHHE 4FW3A 2VQFI 2WP8A 1XHKA 1U2RA 1Z0EA 3JAMQ 4LFCE 1XMOI 1FKAE 4LFBE 4IZKB 4DPXA 3CDJA 5IWAE 1Y4UA 2C37B 3ZM7A 2UUCI 4LFAE 4DU8A 4LF7E 4X62E 1Z0BA 4KQVA 4X66I 4UTGA 2DEJA 5C0XA 3U1YA 4B3SE 4NBQA 1N33E 2HK3A 4JI8I 1MU5A 4X65E 3P3GA 5C0XD 1N34E 4M1KA 4AIMA 4IFDF 3GMEA 1ZM4A 3PYDA 1HR0E 3GLLA 2X36A 3ZKBA 1NHHA 4JG4A 3HKMA 4DR1I 2JEBB 4OZEA 2UUCE 1N32I 2HKJA 3V5RA 4OO1F 3B8HA 4AQYI 4KHPE 5K36A 5C0XE 4USKA 4X66E 4B3TE 1J5EI 4IFDC 4LF6I 4DR7I 4DV0I 4DPUA 2O1WA 3LNUA 4OO1C 1N0VC 2JE6B 3PRYA 4OO1D 2R42A 1Z0WA 4IFDB 2BM0A 3ZZUA 4IZJB 4YY3I 2CG9A 2IERA 4FW5A 1USVA 4B3ME 1HK7A 2O1TA 4MYUA 4LF6E 4OO1E 3ZZTA 1RHYA 2C39A 2NN6F 2CVEA 1WUUA 2PO2A 2Z5CA 4FWDA 2PO0B 2UXDI 4P52A 4PRVA 1QZRA 2Z5EA 1UEKA 3WU6A 2UUAE 1KKHA 2WNRB 2NN6C 4HYMA 4DPTA 4FW7A 1Y5YA 4HY1A 4NXNI 2Z5BA 4YY3E 4LF5I 3UHMA 2VQEI 4DV6I 1FI4A 2UUBI 2ZM6E 1UDSA 1EI1A 2E5LI 3PYEA 2NN6B 2UXBI 1UDOA 5EL9A 4DV5I 5EKWA 4OKGA 4U3BA 3M85D 3OTOE 1XMQI 3JAMC 4GKKI 4DV3I 2X7IA 1H7UA 1FWLA 1VISA 2VESA 1H7SA 5FWKA 1RR9A 3LPSA 3M85G 4DR5E 3Q6NA 4DR2I 4LF4E 2UUBE 4UT4A 1FWKA 1YHCA 2UU9E 4BA1A 1HNWI 3QT8A 4YHHE 4HXZA 3PS2A 1HNXI 4IZKA 2UXBE 4HACB 4DV5E 3GONA 4R1FA 4P7AA 5C0XF 2CZ9A 2C37A 3DD6A 4LF8E 4N3OA 1R6MA 4FWHA 1XMQE 1XXEA 1I94I 4LF9I 2BR2A 4K0KI 5IT9Q 2F1DA 3PYGA 4DV3E 4JYAE 1HNZE 2PNZB 2IOPA 3QT7A 5GMDA 1E3PA 4DR3I 4EMDA 1ZXNA 5C0XC 4JI4I 2WP8B 3ZZ0A 4JI7E 2O3ZA 2V2QA 5GMEA 4DV4I 2PO1B 4AM3A 4JI3I 1FJGI 2V2VA 2VQFE 2ZBKB 3J81Q 4DU7A 2C38B 3T1YI 1XMOE 5K36F 4MYTA 4BA2B 1HNXE 1B62A 1RREA 2BA0D 4WUBA 5BR8I 1IBLI 4QNKA 4X64I 5C0XB 1IBKI 4MU4A 3P3EA 4MQYA 4B3RI 5K36C 1OJ4A 3H4LA 4DR3E 2PNMA 2BA0G 1Z59A 1K47A 5K36D 2J65A 4JI8E 4DR6I 4Z7CA 4DV4E 4XTJA 4USMA 4JI3E 1FJGE 5FLXC 3QT6A 4FW4A 3T1YE 1XNRI 4JV5I 5K36B 1H72C 4FW9A 1EA6A 5K36E 4DR1E 1N32E 3L7ZA 5DNXA 1E3HA 5LMNI 1IBKE 4I3HA 4AQYE 3LTOA 4OO1B 2CGEA 4B3RE 4DV1I 2R3VA 1J5EE 1KIJA 3Q1QA 1PVGA 4DR7E 4MDTA 4DV0E 5FLXQ 4ISAA 1USUA 2ZITA 4GKJI 4QNJA 1H73A 4DR6E 5DRPA 4AIDA 4NXMI 2UXCI 3J80C 1B63A 4DR4I 5DRQA 2GS8A 4JV5E 2A2DA 3PS3A 2C39B 2V34A 2O1VA 3P76A 2PO2B 3HJCA 5JEAA 2Z5CB 4DV1E 2JT2A 4WUCA 4JI1I 2V8PA 1XNQI 1Z0CA 3J80Q 3WU4A 4PRXA 4GKJE 1ZM2A 2IESA 2J7KA 5JEAD 3ZKDA 4OX9I 2UXDE 2IOQA 5ELWA 4J3DA 4DUYI 3KRNA 1YH8A 3D4JA 3PS1A 3U1KA 1S4EA 1MG7A 4NXNE 5A2QQ 4LF5E 5JEAE 2VQEE 4DV6E 4LPFA 5IT9C 4URLA 4LFBI 4LCFA 4JI1E 1OYSA 4LCGA 1Z0VA 1NHJA 2E5LE 2JEAB 4IS9A 4MU1A 4LF7I 4HACA 2LJPA 3J7AM 3J81C 4GKKE 1A6FA 2Q2EB 4DUYE 2EFGA 2GQ0A 2PNZA 2DEIA 4X65I 2F4VI 1N34I 5DNLA 4JI6I 2WW4A 4DR2E 4DV2I 5LL6R 3P3CA 1KTVA 4GQUA 1Y60A 2PO1A 1HR0I 3B78A 1HNWE 1PIEA 4DUZI 2C38A 2BR2B 2GO3A 4BA2A 4KHPI 1R6LA 1BKNA 1ZM3A 4B3TI 2JEBA 1MX0A 4K0KE 4ZVIA 5DRRA 1I94E 4LF9E 3M6AA 1D6TA 1IBMI 4RPFA 3QT5A 4LOMA 1UDQA 4DV7I 2F4VE 4Z7YA
chains in the Genus database with same CATH topology
4LCFA 1YHCA 2J65A 4FW3A 4LCGA 3P3CA 4IS9A 3PS2A 2IESA 5DRPA 4U3DA 4OKGA 4FW4A 4U3BA 5DRQA 2GO3A 4OZEA 4FW7A 4FW6A 4J3DA 1XXEA 5DROA 2IERA 4FW5A 1YH8A 3PS1A 3P3EA 4LCHA 5DRRA 3UHMA 4MQYA 2VESA 3PS3A 1P42A 3U1YA 4ISAA 2GO4A 3P76A 3NZKA 2JT2A 4MDTA 3P3GA 2O3ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LCF A;  1YHC A;  2J65 A;  4FW3 A;  4LCG A;  3P3C A;  4IS9 A;  3PS2 A;  2IES A;  5DRP A;  4U3D A;  4OKG A;  4FW4 A;  4U3B A;  5DRQ A;  2GO3 A;  4OZE A;  4FW7 A;  4FW6 A;  4J3D A;  1XXE A;  5DRO A;  2IER A;  4FW5 A;  1YH8 A;  3PS1 A;  3P3E A;  4LCH A;  5DRR A;  3UHM A;  4MQY A;  2VES A;  3PS3 A;  1P42 A;  3U1Y A;  4ISA A;  2GO4 A;  3P76 A;  3NZK A;  2JT2 A;  4MDT A;  3P3G A;  2O3Z A; 
#chains in the Genus database with same CATH topology
 2NPF A;  2HKE A;  4JI6 E;  4MU3 A;  4DPW A;  1N36 I;  4DV2 E;  3K1J A;  2JE6 A;  3H1C A;  1S16 A;  4FWG A;  2AE8 A;  4DUZ E;  1ZM9 A;  4MU0 A;  1FNM A;  5BR8 E;  4IFD A;  5DRO A;  1IBL E;  4X64 E;  4B3M I;  2V2Z A;  4IZJ A;  4DPY A;  3WU3 A;  4OO1 A;  2O1U A;  1IBM E;  4IFD D;  1NHI A;  4JI2 I;  2HFS A;  4DXL A;  3K85 A;  4IZJ D;  4DV7 E;  2BM1 A;  2UUA I;  2HK2 A;  1N36 E;  1ZXM A;  2PO0 A;  4WUD A;  4JI5 I;  3L7Z B;  3HUL A;  4IFD E;  4FW6 A;  1XNR E;  1VI7 A;  2WNR A;  5JEA F;  2AJ4 A;  2HFU A;  4ED4 A;  1OYP A;  1KVK A;  3GCM A;  2ZM6 I;  5LMN E;  1N0U A;  3B4T A;  2GO4 A;  1Z5C A;  4JI2 E;  1H74 A;  5JEA C;  5A2Q C;  1OYR A;  3V2U C;  1Z0G A;  3OTO I;  2NN6 A;  3WU5 A;  3CWV A;  5LMU I;  4NXM E;  2UXC E;  1Y4S A;  1Y6Z A;  4DR4 E;  2Z5B B;  4JI5 E;  2PNL A;  2NN6 D;  2BA1 D;  4LCH A;  3T1H I;  1P42 A;  4JI0 I;  5JEA B;  4DR5 I;  3J7A G;  2XEX A;  4LF4 I;  2VF3 A;  2HHH I;  2UU9 I;  4YHH I;  3K17 A;  4LFC I;  4PU9 A;  1XNQ E;  2BA1 G;  3M7N D;  2E1R A;  3CDI A;  2NN6 E;  2BV3 A;  5IWA I;  1Z5A A;  1Z5B A;  4LFA I;  1Z0T A;  3P06 A;  4U3D A;  4LF8 I;  4FN5 A;  2JEA A;  2OI2 A;  4X62 I;  1DAR A;  5L3J A;  4JYA I;  1HNZ I;  4OX9 E;  5LMU E;  1UDN A;  3F0N A;  3PYF A;  3M7N G;  4B3S I;  1N33 I;  4JI7 I;  3T1H E;  4JI0 E;  1ELO A;  1PKP A;  3Q6M A;  1NZ0 A;  4JI4 E;  3NZK A;  3B82 A;  2A2C A;  4BA1 B;  2HHH E;  4FW3 A;  2VQF I;  2WP8 A;  1XHK A;  1U2R A;  1Z0E A;  3JAM Q;  4LFC E;  1XMO I;  1FKA E;  4LFB E;  4IZK B;  4DPX A;  3CDJ A;  5IWA E;  1Y4U A;  2C37 B;  3ZM7 A;  2UUC I;  4LFA E;  4DU8 A;  4LF7 E;  4X62 E;  1Z0B A;  4KQV A;  4X66 I;  4UTG A;  2DEJ A;  5C0X A;  3U1Y A;  4B3S E;  4NBQ A;  1N33 E;  2HK3 A;  4JI8 I;  1MU5 A;  4X65 E;  3P3G A;  5C0X D;  1N34 E;  4M1K A;  4AIM A;  4IFD F;  3GME A;  1ZM4 A;  3PYD A;  1HR0 E;  3GLL A;  2X36 A;  3ZKB A;  1NHH A;  4JG4 A;  3HKM A;  4DR1 I;  2JEB B;  4OZE A;  2UUC E;  1N32 I;  2HKJ A;  3V5R A;  4OO1 F;  3B8H A;  4AQY I;  4KHP E;  5K36 A;  5C0X E;  4USK A;  4X66 E;  4B3T E;  1J5E I;  4IFD C;  4LF6 I;  4DR7 I;  4DV0 I;  4DPU A;  2O1W A;  3LNU A;  4OO1 C;  1N0V C;  2JE6 B;  3PRY A;  4OO1 D;  2R42 A;  1Z0W A;  4IFD B;  2BM0 A;  3ZZU A;  4IZJ B;  4YY3 I;  2CG9 A;  2IER A;  4FW5 A;  1USV A;  4B3M E;  1HK7 A;  2O1T A;  4MYU A;  4LF6 E;  4OO1 E;  3ZZT A;  1RHY A;  2C39 A;  2NN6 F;  2CVE A;  1WUU A;  2PO2 A;  2Z5C A;  4FWD A;  2PO0 B;  2UXD I;  4P52 A;  4PRV A;  1QZR A;  2Z5E A;  1UEK A;  3WU6 A;  2UUA E;  1KKH A;  2WNR B;  2NN6 C;  4HYM A;  4DPT A;  4FW7 A;  1Y5Y A;  4HY1 A;  4NXN I;  2Z5B A;  4YY3 E;  4LF5 I;  3UHM A;  2VQE I;  4DV6 I;  1FI4 A;  2UUB I;  2ZM6 E;  1UDS A;  1EI1 A;  2E5L I;  3PYE A;  2NN6 B;  2UXB I;  1UDO A;  5EL9 A;  4DV5 I;  5EKW A;  4OKG A;  4U3B A;  3M85 D;  3OTO E;  1XMQ I;  3JAM C;  4GKK I;  4DV3 I;  2X7I A;  1H7U A;  1FWL A;  1VIS A;  2VES A;  1H7S A;  5FWK A;  1RR9 A;  3LPS A;  3M85 G;  4DR5 E;  3Q6N A;  4DR2 I;  4LF4 E;  2UUB E;  4UT4 A;  1FWK A;  1YHC A;  2UU9 E;  4BA1 A;  1HNW I;  3QT8 A;  4YHH E;  4HXZ A;  3PS2 A;  1HNX I;  4IZK A;  2UXB E;  4HAC B;  4DV5 E;  3GON A;  4R1F A;  4P7A A;  5C0X F;  2CZ9 A;  2C37 A;  3DD6 A;  4LF8 E;  4N3O A;  1R6M A;  4FWH A;  1XMQ E;  1XXE A;  1I94 I;  4LF9 I;  2BR2 A;  4K0K I;  5IT9 Q;  2F1D A;  3PYG A;  4DV3 E;  4JYA E;  1HNZ E;  2PNZ B;  2IOP A;  3QT7 A;  5GMD A;  1E3P A;  4DR3 I;  4EMD A;  1ZXN A;  5C0X C;  4JI4 I;  2WP8 B;  3ZZ0 A;  4JI7 E;  2O3Z A;  2V2Q A;  5GME A;  4DV4 I;  2PO1 B;  4AM3 A;  4JI3 I;  1FJG I;  2V2V A;  2VQF E;  2ZBK B;  3J81 Q;  4DU7 A;  2C38 B;  3T1Y I;  1XMO E;  5K36 F;  4MYT A;  4BA2 B;  1HNX E;  1B62 A;  1RRE A;  2BA0 D;  4WUB A;  5BR8 I;  1IBL I;  4QNK A;  4X64 I;  5C0X B;  1IBK I;  4MU4 A;  3P3E A;  4MQY A;  4B3R I;  5K36 C;  1OJ4 A;  3H4L A;  4DR3 E;  2PNM A;  2BA0 G;  1Z59 A;  1K47 A;  5K36 D;  2J65 A;  4JI8 E;  4DR6 I;  4Z7C A;  4DV4 E;  4XTJ A;  4USM A;  4JI3 E;  1FJG E;  5FLX C;  3QT6 A;  4FW4 A;  3T1Y E;  1XNR I;  4JV5 I;  5K36 B;  1H72 C;  4FW9 A;  1EA6 A;  5K36 E;  4DR1 E;  1N32 E;  3L7Z A;  5DNX A;  1E3H A;  5LMN I;  1IBK E;  4I3H A;  4AQY E;  3LTO A;  4OO1 B;  2CGE A;  4B3R E;  4DV1 I;  2R3V A;  1J5E E;  1KIJ A;  3Q1Q A;  1PVG A;  4DR7 E;  4MDT A;  4DV0 E;  5FLX Q;  4ISA A;  1USU A;  2ZIT A;  4GKJ I;  4QNJ A;  1H73 A;  4DR6 E;  5DRP A;  4AID A;  4NXM I;  2UXC I;  3J80 C;  1B63 A;  4DR4 I;  5DRQ A;  2GS8 A;  4JV5 E;  2A2D A;  3PS3 A;  2C39 B;  2V34 A;  2O1V A;  3P76 A;  2PO2 B;  3HJC A;  5JEA A;  2Z5C B;  4DV1 E;  2JT2 A;  4WUC A;  4JI1 I;  2V8P A;  1XNQ I;  1Z0C A;  3J80 Q;  3WU4 A;  4PRX A;  4GKJ E;  1ZM2 A;  2IES A;  2J7K A;  5JEA D;  3ZKD A;  4OX9 I;  2UXD E;  2IOQ A;  5ELW A;  4J3D A;  4DUY I;  3KRN A;  1YH8 A;  3D4J A;  3PS1 A;  3U1K A;  1S4E A;  1MG7 A;  4NXN E;  5A2Q Q;  4LF5 E;  5JEA E;  2VQE E;  4DV6 E;  4LPF A;  5IT9 C;  4URL A;  4LFB I;  4LCF A;  4JI1 E;  1OYS A;  4LCG A;  1Z0V A;  1NHJ A;  2E5L E;  2JEA B;  4IS9 A;  4MU1 A;  4LF7 I;  4HAC A;  2LJP A;  3J7A M;  3J81 C;  4GKK E;  1A6F A;  2Q2E B;  4DUY E;  2EFG A;  2GQ0 A;  2PNZ A;  2DEI A;  4X65 I;  2F4V I;  1N34 I;  5DNL A;  4JI6 I;  2WW4 A;  4DR2 E;  4DV2 I;  5LL6 R;  3P3C A;  1KTV A;  4GQU A;  1Y60 A;  2PO1 A;  1HR0 I;  3B78 A;  1HNW E;  1PIE A;  4DUZ I;  2C38 A;  2BR2 B;  2GO3 A;  4BA2 A;  4KHP I;  1R6L A;  1BKN A;  1ZM3 A;  4B3T I;  2JEB A;  1MX0 A;  4K0K E;  4ZVI A;  5DRR A;  1I94 E;  4LF9 E;  3M6A A;  1D6T A;  1IBM I;  4RPF A;  3QT5 A;  4LOM A;  1UDQ A;  4DV7 I;  2F4V E;  4Z7Y A; 
#chains in the Genus database with same CATH homology
 4LCF A;  1YHC A;  2J65 A;  4FW3 A;  4LCG A;  3P3C A;  4IS9 A;  3PS2 A;  2IES A;  5DRP A;  4U3D A;  4OKG A;  4FW4 A;  4U3B A;  5DRQ A;  2GO3 A;  4OZE A;  4FW7 A;  4FW6 A;  4J3D A;  1XXE A;  5DRO A;  2IER A;  4FW5 A;  1YH8 A;  3PS1 A;  3P3E A;  4LCH A;  5DRR A;  3UHM A;  4MQY A;  2VES A;  3PS3 A;  1P42 A;  3U1Y A;  4ISA A;  2GO4 A;  3P76 A;  3NZK A;  2JT2 A;  4MDT A;  3P3G A;  2O3Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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