2IESA

Crystal structure of aquifex aeolicus lpxc complexed with pyrophosphate
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
267
structure length
267
Chain Sequence
GLEKTVKEKLSFEGVGIHTGEYSKLIIHPEKEGTGIRFFKNGVYIPARHEFVVHTNHSTDLGFKGQRIKTVEHILSVLHLLEITNVTIEVIGNEIPILDGSGWEFYEAIRKNILNQNREIDYFVVEEPIIVEDEGRLIKAEPSDTLEVTYEGEFKNFLGRQKFTFVEGNEEEIVLARTFAFDWEIEHIKKVGLGKGGSLKNTLVLGKDKVYNPEGLRYENEPVRHKVFDLIGDLYLLGSPVKGKFYSFRGGHSLNVKLVKELAKKQK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
publication title Binding of Uridine 5-Diphosphate in the Basic Patch of the Zinc Metalloenzyme Deacetylase LpxC and Implications for Substrate Binding
pubmed doi rcsb
source organism Aquifex aeolicus
molecule tags Hydrolase
total genus 85
structure length 267
sequence length 267
chains with identical sequence B
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2006-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 2iesA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 2iesA02
4OZEA 4FW7A 4IS9A 4MQYA 4OKGA 4J3DA 4LCFA 3P3CA 2GO4A 3PS2A 3NZKA 3P3GA 2J65A 4FW4A 4LCGA 2GO3A 4ISAA 3PS3A 3U1YA 4FW5A 3P76A 1YH8A 5DROA 2IERA 4U3BA 5DRQA 2IESA 4MDTA 3PS1A 2VESA 5DRRA 5DRPA 1P42A 3UHMA 2O3ZA 3P3EA 1YHCA 1XXEA 2JT2A 4U3DA 4FW3A 4FW6A 4LCHA
chains in the Genus database with same CATH superfamily
4DR5E 5ELWA 2O1UA 4BA1A 3B78A 5C0XF 4OO1D 1NHJA 3T1YE 1Z5BA 4KHPI 2WP8B 3KRNA 4HY1A 4DV6I 3QT7A 3J80C 3WU4A 3ZKDA 3PYEA 3ZKBA 5C0XE 4JYAI 1RR9A 4DV0E 2NN6C 5JEAD 3P3EA 2C37A 4LF7I 4JV5E 4X66I 1IBLI 4KQVA 4FW6A 4JI1I 4IFDB 2NN6F 1H7SA 2GS8A 1H73A 3P3CA 1FWLA 4JG4A 4X62I 3V2UC 2LJPA 4LCGA 2O1TA 4YY3E 2J7KA 2C39A 1A6FA 1EA6A 1UEKA 3CDJA 3QT8A 2WNRB 3J7AG 2BV3A 5DRRA 2UUAE 2PO2A 3OTOI 4DR3I 1P42A 3Q6MA 2PO1B 1XMOI 1I94E 1ZM4A 2V2QA 2Z5CA 4JI5E 2XEXA 4URLA 3H1CA 2A2CA 4OKGA 4MQYA 3M85G 3L7ZB 1Z0GA 5BR8E 4DU7A 1H74A 4LF8I 4R1FA 4FW9A 4RPFA 4OO1C 4DPXA 2AE8A 4JI8E 2HFSA 4FW5A 5C0XB 5K36D 4Z7YA 4NXNI 4USKA 4U3BA 3P06A 4DV2I 2UUCI 4OO1F 4LF9E 2UXCE 1KKHA 2JEAB 3H4LA 4JI2I 4B3ME 1XNRE 4LF4E 4M1KA 5JEAC 2AJ4A 4MU4A 1OYRA 4DUZI 3J7AM 2UUCE 4DR7I 2V2ZA 2OI2A 3B8HA 4FWHA 1KTVA 5JEAF 1Z0TA 3PS2A 2JEBA 3V5RA 1QZRA 2NN6B 2UUBE 2E5LI 3P76A 4LFAI 4X65I 3HKMA 3JAMC 4JI6I 4HYMA 5JEAE 4IZJA 1ZM9A 5GMDA 3ZZTA 3JAMQ 4WUBA 1H72C 3GMEA 4DPUA 4AQYE 1OJ4A 1R6MA 1Z5AA 2E5LE 3LPSA 4X65E 2CGEA 4IFDE 4JI6E 1ZXNA 2Q2EB 4LCFA 4DV5E 2UXBI 3B82A 1Z0VA 3P3GA 3ZZUA 2BA1D 4DV3I 1Y6ZA 2UU9E 2F4VE 5K36C 1OYPA 4FWDA 4USMA 2HKEA 5LMUE 2O1VA 2BR2A 4K0KI 4DR2E 4IZKA 4JI0E 3D4JA 4DV1I 4DV3E 2UXDE 5K36F 4OO1B 3WU6A 2DEIA 2VF3A 3B4TA 2BM0A 2C38B 4DR7E 2A2DA 5K36E 4BA1B 2IESA 4DPTA 4QNJA 5JEAB 2BM1A 3J80Q 1HK7A 1HNZI 5DRPA 1N0UA 4JI7I 3HULA 4KHPE 4DV6E 4FW3A 4LFCI 4GKJI 3PYFA 1B62A 4FW7A 1HR0I 4JYAE 1IBMI 1N36I 4P52A 1MG7A 2R3VA 2C37B 2V8PA 4JI4I 5FLXC 2GQ0A 4LF7E 4X66E 1IBLE 4GKJE 1USUA 4ZVIA 4JI1E 2NN6E 3PS1A 1HR0E 1IBKI 3CWVA 1ZXMA 2ZM6I 3GONA 3K1JA 4X62E 4B3SI 3LTOA 3WU5A 2WNRA 4LF6I 2BA0D 4Z7CA 4LPFA 5FWKA 2PO1A 4LOMA 3PYDA 2NPFA 4GKKI 2WW4A 3OTOE 4DR3E 4B3RI 2F1DA 2J65A 1XMOE 5K36B 2BA1G 1S16A 4P7AA 1FJGI 3L7ZA 1MU5A 5DNXA 3T1HI 1N33I 1FWKA 4UTGA 2O3ZA 5A2QC 4DV4I 4LF8E 5C0XA 3PYGA 1KVKA 1N32I 1PIEA 4OZEA 1PKPA 1XNQI 2JEAA 1HNXI 4NXNE 1N34I 4BA2B 4J3DA 4DV2E 4OO1E 4NXMI 1R6LA 4JI2E 2CVEA 4FWGA 1Z0CA 1UDNA 4FW4A 2VQFI 4UT4A 2IERA 4DR1I 4MU3A 2DEJA 4DUZE 1N34E 1USVA 3CDIA 4YHHI 4DUYI 4B3TI 2JEBB 4FN5A 4NBQA 4X64I 3Q6NA 2Z5BB 2JE6B 5LMNI 1Z5CA 4LFAE 2HK2A 1ZM2A 5GMEA 2GO4A 5IT9C 4OX9I 2GO3A 2PNZB 1WUUA 3PS3A 1J5EI 4LF5I 2HHHI 4IZJD 2E1RA 1UDOA 4LFBI 1XHKA 4MYTA 3M7ND 4DPYA 1UDQA 3J81C 2UXBE 2HHHE 3ZZ0A 1EI1A 3PRYA 2PO0B 2BA0G 1BKNA 2IOQA 4HACB 1Y4SA 4DU8A 1DARA 3U1YA 4DV7I 4K0KE 4IZKB 4DR5I 2ZITA 4DV1E 5DRQA 1VI7A 3T1YI 4HXZA 2Z5EA 5C0XC 2WP8A 3WU3A 2X36A 1XXEA 2JT2A 4DV7E 3Q1QA 4QNKA 3QT5A 2HK3A 5JEAA 5L3JA 1Z0EA 4DV0I 4JI3I 1U2RA 1HNZE 4JV5I 4JI7E 1B63A 2PNMA 4IFDA 1Z59A 4LFCE 5DROA 3DD6A 5FLXQ 2VESA 4JI3E 1E3HA 2EFGA 1IBME 1N36E 2CZ9A 3K17A 1UDSA 4U3DA 4YY3I 4JI4E 4PRVA 1KIJA 1MX0A 1N0VC 2HFUA 2C39B 1Z0WA 4IFDD 2UUAI 1I94I 1Y4UA 1IBKE 1H7UA 3NZKA 2PO2B 5LL6R 1OYSA 2ZM6E 4ISAA 4JI5I 1Z0BA 1NHHA 1HNWI 4B3SE 2Z5CB 4LF6E 5BR8I 1ELOA 1RREA 4AIDA 3M7NG 4JI8I 5K36A 4GKKE 2HKJA 4B3RE 3ZM7A 1HNWE 2UXCI 4LF9I 4MU1A 4XTJA 5A2QQ 1FJGE 1ZM3A 4B3MI 1XNRI 2V2VA 4LF4I 3T1HE 1N33E 4ED4A 4DV4E 4DXLA 3F0NA 1NZ0A 1N32E 4BA2A 4I3HA 5EL9A 2VQEI 5C0XD 2R42A 4N3OA 4WUCA 1XNQE 1HNXE 4PRXA 3UHMA 4NXME 5IWAI 2UUBI 2NN6A 2VQFE 2IOPA 1FKAE 1FNMA 2VQEE 1NHIA 3GLLA 4DR1E 4AIMA 3LNUA 4YHHE 4IFDC 4IZJB 4DUYE 4AQYI 3U1KA 5IWAE 2Z5BA 4B3TE 2JE6A 4X64E 1Y60A 1YH8A 2NN6D 5IT9Q 4IFDF 1S4EA 3HJCA 5LMNE 5DNLA 1PVGA 1RHYA 4DV5I 2ZBKB 1VISA 1K47A 2PNZA 1YHCA 2V34A 4OX9E 1J5EE 4LF5E 3QT6A 4IS9A 3J81Q 2UU9I 4DR4I 3M85D 2F4VI 5EKWA 4MU0A 2CG9A 3GCMA 5LMUI 4LFBE 4MYUA 4PU9A 4DR2I 4WUDA 4JI0I 2O1WA 1E3PA 1XMQI 2BR2B 3M6AA 2UXDI 4DR6I 4OO1A 2PO0A 4DPWA 1FI4A 4DR4E 4MDTA 4AM3A 1Y5YA 4HACA 3K85A 4GQUA 2PNLA 1D6TA 1XMQE 2X7IA 2C38A 4EMDA 4DR6E 4LCHA
chains in the Genus database with same CATH topology
4OZEA 4FW7A 4IS9A 4MQYA 4OKGA 4J3DA 4LCFA 3P3CA 2GO4A 3PS2A 3NZKA 3P3GA 2J65A 4FW4A 4LCGA 2GO3A 4ISAA 3PS3A 3U1YA 4FW5A 3P76A 1YH8A 5DROA 2IERA 4U3BA 5DRQA 2IESA 4MDTA 3PS1A 2VESA 5DRRA 5DRPA 1P42A 3UHMA 2O3ZA 3P3EA 1YHCA 1XXEA 2JT2A 4U3DA 4FW3A 4FW6A 4LCHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OZE A;  4FW7 A;  4IS9 A;  4MQY A;  4OKG A;  4J3D A;  4LCF A;  3P3C A;  2GO4 A;  3PS2 A;  3NZK A;  3P3G A;  2J65 A;  4FW4 A;  4LCG A;  2GO3 A;  4ISA A;  3PS3 A;  3U1Y A;  4FW5 A;  3P76 A;  1YH8 A;  5DRO A;  2IER A;  4U3B A;  5DRQ A;  2IES A;  4MDT A;  3PS1 A;  2VES A;  5DRR A;  5DRP A;  1P42 A;  3UHM A;  2O3Z A;  3P3E A;  1YHC A;  1XXE A;  2JT2 A;  4U3D A;  4FW3 A;  4FW6 A;  4LCH A; 
#chains in the Genus database with same CATH topology
 4DR5 E;  5ELW A;  2O1U A;  4BA1 A;  3B78 A;  5C0X F;  4OO1 D;  1NHJ A;  3T1Y E;  1Z5B A;  4KHP I;  2WP8 B;  3KRN A;  4HY1 A;  4DV6 I;  3QT7 A;  3J80 C;  3WU4 A;  3ZKD A;  3PYE A;  3ZKB A;  5C0X E;  4JYA I;  1RR9 A;  4DV0 E;  2NN6 C;  5JEA D;  3P3E A;  2C37 A;  4LF7 I;  4JV5 E;  4X66 I;  1IBL I;  4KQV A;  4FW6 A;  4JI1 I;  4IFD B;  2NN6 F;  1H7S A;  2GS8 A;  1H73 A;  3P3C A;  1FWL A;  4JG4 A;  4X62 I;  3V2U C;  2LJP A;  4LCG A;  2O1T A;  4YY3 E;  2J7K A;  2C39 A;  1A6F A;  1EA6 A;  1UEK A;  3CDJ A;  3QT8 A;  2WNR B;  3J7A G;  2BV3 A;  5DRR A;  2UUA E;  2PO2 A;  3OTO I;  4DR3 I;  1P42 A;  3Q6M A;  2PO1 B;  1XMO I;  1I94 E;  1ZM4 A;  2V2Q A;  2Z5C A;  4JI5 E;  2XEX A;  4URL A;  3H1C A;  2A2C A;  4OKG A;  4MQY A;  3M85 G;  3L7Z B;  1Z0G A;  5BR8 E;  4DU7 A;  1H74 A;  4LF8 I;  4R1F A;  4FW9 A;  4RPF A;  4OO1 C;  4DPX A;  2AE8 A;  4JI8 E;  2HFS A;  4FW5 A;  5C0X B;  5K36 D;  4Z7Y A;  4NXN I;  4USK A;  4U3B A;  3P06 A;  4DV2 I;  2UUC I;  4OO1 F;  4LF9 E;  2UXC E;  1KKH A;  2JEA B;  3H4L A;  4JI2 I;  4B3M E;  1XNR E;  4LF4 E;  4M1K A;  5JEA C;  2AJ4 A;  4MU4 A;  1OYR A;  4DUZ I;  3J7A M;  2UUC E;  4DR7 I;  2V2Z A;  2OI2 A;  3B8H A;  4FWH A;  1KTV A;  5JEA F;  1Z0T A;  3PS2 A;  2JEB A;  3V5R A;  1QZR A;  2NN6 B;  2UUB E;  2E5L I;  3P76 A;  4LFA I;  4X65 I;  3HKM A;  3JAM C;  4JI6 I;  4HYM A;  5JEA E;  4IZJ A;  1ZM9 A;  5GMD A;  3ZZT A;  3JAM Q;  4WUB A;  1H72 C;  3GME A;  4DPU A;  4AQY E;  1OJ4 A;  1R6M A;  1Z5A A;  2E5L E;  3LPS A;  4X65 E;  2CGE A;  4IFD E;  4JI6 E;  1ZXN A;  2Q2E B;  4LCF A;  4DV5 E;  2UXB I;  3B82 A;  1Z0V A;  3P3G A;  3ZZU A;  2BA1 D;  4DV3 I;  1Y6Z A;  2UU9 E;  2F4V E;  5K36 C;  1OYP A;  4FWD A;  4USM A;  2HKE A;  5LMU E;  2O1V A;  2BR2 A;  4K0K I;  4DR2 E;  4IZK A;  4JI0 E;  3D4J A;  4DV1 I;  4DV3 E;  2UXD E;  5K36 F;  4OO1 B;  3WU6 A;  2DEI A;  2VF3 A;  3B4T A;  2BM0 A;  2C38 B;  4DR7 E;  2A2D A;  5K36 E;  4BA1 B;  2IES A;  4DPT A;  4QNJ A;  5JEA B;  2BM1 A;  3J80 Q;  1HK7 A;  1HNZ I;  5DRP A;  1N0U A;  4JI7 I;  3HUL A;  4KHP E;  4DV6 E;  4FW3 A;  4LFC I;  4GKJ I;  3PYF A;  1B62 A;  4FW7 A;  1HR0 I;  4JYA E;  1IBM I;  1N36 I;  4P52 A;  1MG7 A;  2R3V A;  2C37 B;  2V8P A;  4JI4 I;  5FLX C;  2GQ0 A;  4LF7 E;  4X66 E;  1IBL E;  4GKJ E;  1USU A;  4ZVI A;  4JI1 E;  2NN6 E;  3PS1 A;  1HR0 E;  1IBK I;  3CWV A;  1ZXM A;  2ZM6 I;  3GON A;  3K1J A;  4X62 E;  4B3S I;  3LTO A;  3WU5 A;  2WNR A;  4LF6 I;  2BA0 D;  4Z7C A;  4LPF A;  5FWK A;  2PO1 A;  4LOM A;  3PYD A;  2NPF A;  4GKK I;  2WW4 A;  3OTO E;  4DR3 E;  4B3R I;  2F1D A;  2J65 A;  1XMO E;  5K36 B;  2BA1 G;  1S16 A;  4P7A A;  1FJG I;  3L7Z A;  1MU5 A;  5DNX A;  3T1H I;  1N33 I;  1FWK A;  4UTG A;  2O3Z A;  5A2Q C;  4DV4 I;  4LF8 E;  5C0X A;  3PYG A;  1KVK A;  1N32 I;  1PIE A;  4OZE A;  1PKP A;  1XNQ I;  2JEA A;  1HNX I;  4NXN E;  1N34 I;  4BA2 B;  4J3D A;  4DV2 E;  4OO1 E;  4NXM I;  1R6L A;  4JI2 E;  2CVE A;  4FWG A;  1Z0C A;  1UDN A;  4FW4 A;  2VQF I;  4UT4 A;  2IER A;  4DR1 I;  4MU3 A;  2DEJ A;  4DUZ E;  1N34 E;  1USV A;  3CDI A;  4YHH I;  4DUY I;  4B3T I;  2JEB B;  4FN5 A;  4NBQ A;  4X64 I;  3Q6N A;  2Z5B B;  2JE6 B;  5LMN I;  1Z5C A;  4LFA E;  2HK2 A;  1ZM2 A;  5GME A;  2GO4 A;  5IT9 C;  4OX9 I;  2GO3 A;  2PNZ B;  1WUU A;  3PS3 A;  1J5E I;  4LF5 I;  2HHH I;  4IZJ D;  2E1R A;  1UDO A;  4LFB I;  1XHK A;  4MYT A;  3M7N D;  4DPY A;  1UDQ A;  3J81 C;  2UXB E;  2HHH E;  3ZZ0 A;  1EI1 A;  3PRY A;  2PO0 B;  2BA0 G;  1BKN A;  2IOQ A;  4HAC B;  1Y4S A;  4DU8 A;  1DAR A;  3U1Y A;  4DV7 I;  4K0K E;  4IZK B;  4DR5 I;  2ZIT A;  4DV1 E;  5DRQ A;  1VI7 A;  3T1Y I;  4HXZ A;  2Z5E A;  5C0X C;  2WP8 A;  3WU3 A;  2X36 A;  1XXE A;  2JT2 A;  4DV7 E;  3Q1Q A;  4QNK A;  3QT5 A;  2HK3 A;  5JEA A;  5L3J A;  1Z0E A;  4DV0 I;  4JI3 I;  1U2R A;  1HNZ E;  4JV5 I;  4JI7 E;  1B63 A;  2PNM A;  4IFD A;  1Z59 A;  4LFC E;  5DRO A;  3DD6 A;  5FLX Q;  2VES A;  4JI3 E;  1E3H A;  2EFG A;  1IBM E;  1N36 E;  2CZ9 A;  3K17 A;  1UDS A;  4U3D A;  4YY3 I;  4JI4 E;  4PRV A;  1KIJ A;  1MX0 A;  1N0V C;  2HFU A;  2C39 B;  1Z0W A;  4IFD D;  2UUA I;  1I94 I;  1Y4U A;  1IBK E;  1H7U A;  3NZK A;  2PO2 B;  5LL6 R;  1OYS A;  2ZM6 E;  4ISA A;  4JI5 I;  1Z0B A;  1NHH A;  1HNW I;  4B3S E;  2Z5C B;  4LF6 E;  5BR8 I;  1ELO A;  1RRE A;  4AID A;  3M7N G;  4JI8 I;  5K36 A;  4GKK E;  2HKJ A;  4B3R E;  3ZM7 A;  1HNW E;  2UXC I;  4LF9 I;  4MU1 A;  4XTJ A;  5A2Q Q;  1FJG E;  1ZM3 A;  4B3M I;  1XNR I;  2V2V A;  4LF4 I;  3T1H E;  1N33 E;  4ED4 A;  4DV4 E;  4DXL A;  3F0N A;  1NZ0 A;  1N32 E;  4BA2 A;  4I3H A;  5EL9 A;  2VQE I;  5C0X D;  2R42 A;  4N3O A;  4WUC A;  1XNQ E;  1HNX E;  4PRX A;  3UHM A;  4NXM E;  5IWA I;  2UUB I;  2NN6 A;  2VQF E;  2IOP A;  1FKA E;  1FNM A;  2VQE E;  1NHI A;  3GLL A;  4DR1 E;  4AIM A;  3LNU A;  4YHH E;  4IFD C;  4IZJ B;  4DUY E;  4AQY I;  3U1K A;  5IWA E;  2Z5B A;  4B3T E;  2JE6 A;  4X64 E;  1Y60 A;  1YH8 A;  2NN6 D;  5IT9 Q;  4IFD F;  1S4E A;  3HJC A;  5LMN E;  5DNL A;  1PVG A;  1RHY A;  4DV5 I;  2ZBK B;  1VIS A;  1K47 A;  2PNZ A;  1YHC A;  2V34 A;  4OX9 E;  1J5E E;  4LF5 E;  3QT6 A;  4IS9 A;  3J81 Q;  2UU9 I;  4DR4 I;  3M85 D;  2F4V I;  5EKW A;  4MU0 A;  2CG9 A;  3GCM A;  5LMU I;  4LFB E;  4MYU A;  4PU9 A;  4DR2 I;  4WUD A;  4JI0 I;  2O1W A;  1E3P A;  1XMQ I;  2BR2 B;  3M6A A;  2UXD I;  4DR6 I;  4OO1 A;  2PO0 A;  4DPW A;  1FI4 A;  4DR4 E;  4MDT A;  4AM3 A;  1Y5Y A;  4HAC A;  3K85 A;  4GQU A;  2PNL A;  1D6T A;  1XMQ E;  2X7I A;  2C38 A;  4EMD A;  4DR6 E;  4LCH A; 
#chains in the Genus database with same CATH homology
 4OZE A;  4FW7 A;  4IS9 A;  4MQY A;  4OKG A;  4J3D A;  4LCF A;  3P3C A;  2GO4 A;  3PS2 A;  3NZK A;  3P3G A;  2J65 A;  4FW4 A;  4LCG A;  2GO3 A;  4ISA A;  3PS3 A;  3U1Y A;  4FW5 A;  3P76 A;  1YH8 A;  5DRO A;  2IER A;  4U3B A;  5DRQ A;  2IES A;  4MDT A;  3PS1 A;  2VES A;  5DRR A;  5DRP A;  1P42 A;  3UHM A;  2O3Z A;  3P3E A;  1YHC A;  1XXE A;  2JT2 A;  4U3D A;  4FW3 A;  4FW6 A;  4LCH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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